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Literature summary for 3.4.16.4 extracted from

  • Ghuysen, J.M.; Frere, J.M.; Leyh-Bouille, M.; Nguyen-Disteche, M.; Coyette, J.; Dusart, J.; Charlier, P.; Dive, G.; Lamotte-Brasseur, J.
    Bacterial wall peptidoglycan, DD-peptidases and beta-lactam antibiotics (1984), Scand. J. Infect. Dis., 42, 17-37.
    View publication on PubMed
Search for more literature for 3.4.16.4

Inhibitors

Inhibitors Comment Organism Structure
beta-lactams kinetic constants Actinomadura sp.
beta-lactams kinetic constants Streptomyces sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine Streptomyces sp.
-
 ?
-
 ?
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine Actinomadura sp.
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Actinomadura sp.
-
 R39
-
Streptomyces sp.
-
 R61
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information requirement for D-Ala in P1 position Streptomyces sp. ?
-
 ?
additional information requirement for D-Ala in P1 position Actinomadura sp. ?
-
 ?
Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + Gly-Gly acceptors in transpeptidase reaction Streptomyces sp. Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-Gly-Gly + D-Ala
-
 ?
Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + H2O
-
 Streptomyces sp. Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala + D-alanine
-
 ?
Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + H2O
-
 Actinomadura sp. Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala + D-alanine
-
 ?
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine
-
 Streptomyces sp. ?
-
 ?
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine
-
 Actinomadura sp. ?
-
 ?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine + H2O
-
 Streptomyces sp. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanine + D-alanine
-
 ?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine + H2O
-
 Actinomadura sp. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanine + D-alanine
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
17.5
-
 diacetyl-L-Lys-D-Ala-D-Ala Streptomyces sp. R39 Streptomyces sp.
55
-
 diacetyl-L-Lys-D-Ala-D-Ala Streptomyces sp. R61 Streptomyces sp.