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Information on EC 3.2.2.7 - adenosine nucleosidase
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EC Tree
3.2.2.7 adenosine nucleosidaseIUBMB Comments
Also acts on adenosine N-oxide.
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Word Map
- 3.2.2.7
- purine
- nucleoside
-
salvage
- riboside
- inosine
-
lupinus
- luteus
-
8-14cadenosine
-
3.3.1.1
- s-adenosyl-l-homocysteine
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
adenosine nucleosidase, adenosinase, adenosine hydrolase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
adenosinase
-
-
-
-
adenosine hydrolase
-
-
-
-
ANase
-
-
-
-
N-ribosyladenine ribohydrolase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
adenosine + H2O = D-ribose + adenine
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of N-glycosyl bond
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
adenosine ribohydrolase
Also acts on adenosine N-oxide.
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CAS REGISTRY NUMBER
COMMENTARY
9075-41-6
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3'-deoxyadenosine + H2O
6-aminopurine + 3-deoxy-D-ribofuranose
-
6-aminopurine-9-3'-deoxy-beta-D-ribofuranoside, cordycepin, very low activity
-
?
5'-deoxyadenosine + H2O
6-aminopurine + 5-deoxy-D-ribofuranose
-
6-aminopurine-9-5'-deoxy-beta-D-ribofuranoside, best substrate
-
?
6-aminopurine-9-beta-D-ribofuranosyl-N1-oxide + H2O
6-aminopurine-N1-oxide + D-ribofuranose
6-benzylaminopurine riboside + H2O
6-benzylaminopurine + D-ribose
-
low activity
-
?
7-methyl-6-aminopurine-9-beta-D-ribofuranoside + H2O
7-methyl-6-aminopurine + D-ribofuranose
-
5fold faster hydrolysis compared to adenosine
-
?
guanosine + H2O
2-amino-1,9-dihydropurine-6-on + D-ribofuranose
-
2-amino-1,9-dihydro-6-oxopurine-9-beta-D-ribofuranoside, two third lowered activity compared to adenosine as substrate
-
?
N6-(DELTA2-isopentenyl)-adenosine + H2O
N6-(DELTA2-isopentenyl)-6-aminopurine + D-ribofuranose
-
N6-(DELTA2-isopentenyl)-6-aminopurine-9-beta-D-ribofuranoside
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
hydrolysis at the same rate as for adenosine
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
3-4 times greater hydrolysis compared to adenosine
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
hydrolyzes at 96% of the rate of adenosine
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
one third lowered activity compared to adenosine as substrate
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
hydrolysis at the same rate as for adenosine
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside
-
?
6-aminopurine-9-beta-D-ribofuranosyl-N1-oxide + H2O
6-aminopurine-N1-oxide + D-ribofuranose
-
rapid hydrolysis
-
?
6-aminopurine-9-beta-D-ribofuranosyl-N1-oxide + H2O
6-aminopurine-N1-oxide + D-ribofuranose
-
same hydrolysis rate than for adenosine or 2'-deoxyadenosine
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
component of the purine salvage pathway
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
component of the purine salvage pathway
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
component of the purine salvage pathway
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
component of the purine salvage pathway
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
involved in maintaining an active pool of S-adenosyl-L-methionine for transmethylation reactions
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
component of the purine salvage pathway
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
implicated in metabolism of cytokinins
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
implicated in metabolism of cytokinins
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
component of the purine salvage pathway
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
Ulmus carpinifolia
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
inosine + H2O
hypoxanthine + D-ribose
-
9-ribosylhydroxanthine, low activity
-
?
additional information
?
-
-
the pure recombinant protein exhibits highest hydrolase activity for uridine, followed by inosine and adenosine
-
-
?
additional information
?
-
-
56-92% of adenosine taken up by leaf disks may be converted to salvage products, efficient adenosine salvage abilitiy in mangrove is coupled to high enzymic activity and is stimulated by salt, proposed metabolic pathway
-
-
?
additional information
?
-
-
56-92% of adenosine taken up by leaf disks may be converted to salvage products, efficient adenosine salvage abilitiy in mangrove is coupled to high enzymic activity and is stimulated by salt, proposed metabolic pathway
-
-
?
additional information
?
-
-
proposed pathway for biosynthesis of purine alkaloids with adenosine derived from SAM cycle
-
-
?
additional information
?
-
-
56-92% of adenosine taken up by leaf disks may be converted to salvage products, efficient adenosine salvage abilitiy in mangrove is coupled to high enzymic activity and is stimulated by salt, proposed metabolic pathway
-
-
?
additional information
?
-
-
30% of adenosine taken up by leaf disks may be converted to salvage products
-
-
?
additional information
?
-
-
30% of adenosine taken up by leaf disks is hydrolysed to adenine
-
-
?
additional information
?
-
-
all of the ribonucleosides tested are better substrates than their corresponding 2'-deoxynucleosides. The purines are better substrates than the pyrimidines
-
-
?
additional information
?
-
-
56-92% of adenosine taken up by leaf disks may be converted to salvage products, efficient adenosine salvage abilitiy in mangrove is coupled to high enzymic activity and is stimulated by salt, proposed metabolic pathway
-
-
?
additional information
?
-
-
56-92% of adenosine taken up by leaf disks may be converted to salvage products, efficient adenosine salvage abilitiy in mangrove is coupled to high enzymic activity and is stimulated by salt, proposed metabolic pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
hydrolysis at the same rate as for adenosine
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
3-4 times greater hydrolysis compared to adenosine
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
hydrolyzes at 96% of the rate of adenosine
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
one third lowered activity compared to adenosine as substrate
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
hydrolysis at the same rate as for adenosine
-
?
2'-deoxyadenosine + H2O
6-aminopurine + 2-deoxy-D-ribofuranose
-
6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
component of the purine salvage pathway
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
component of the purine salvage pathway
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
component of the purine salvage pathway
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
component of the purine salvage pathway
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
involved in maintaining an active pool of S-adenosyl-L-methionine for transmethylation reactions
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
component of the purine salvage pathway
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
implicated in metabolism of cytokinins
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
adenosine + H2O
6-aminopurine + D-ribofuranose
-
implicated in metabolism of cytokinins
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
component of the purine salvage pathway
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
-
6-aminopurine-9-beta-D-ribofuranoside
-
?
adenosine + H2O
6-aminopurine + D-ribofuranose
Ulmus carpinifolia
-
6-aminopurine-9-beta-D-ribofuranoside
-
ir
additional information
?
-
-
56-92% of adenosine taken up by leaf disks may be converted to salvage products, efficient adenosine salvage abilitiy in mangrove is coupled to high enzymic activity and is stimulated by salt, proposed metabolic pathway
-
-
?
additional information
?
-
-
56-92% of adenosine taken up by leaf disks may be converted to salvage products, efficient adenosine salvage abilitiy in mangrove is coupled to high enzymic activity and is stimulated by salt, proposed metabolic pathway
-
-
?
additional information
?
-
-
proposed pathway for biosynthesis of purine alkaloids with adenosine derived from SAM cycle
-
-
?
additional information
?
-
-
56-92% of adenosine taken up by leaf disks may be converted to salvage products, efficient adenosine salvage abilitiy in mangrove is coupled to high enzymic activity and is stimulated by salt, proposed metabolic pathway
-
-
?
additional information
?
-
-
30% of adenosine taken up by leaf disks may be converted to salvage products
-
-
?
additional information
?
-
-
30% of adenosine taken up by leaf disks is hydrolysed to adenine
-
-
?
additional information
?
-
-
56-92% of adenosine taken up by leaf disks may be converted to salvage products, efficient adenosine salvage abilitiy in mangrove is coupled to high enzymic activity and is stimulated by salt, proposed metabolic pathway
-
-
?
additional information
?
-
-
56-92% of adenosine taken up by leaf disks may be converted to salvage products, efficient adenosine salvage abilitiy in mangrove is coupled to high enzymic activity and is stimulated by salt, proposed metabolic pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Inosine
-
at 0.2 mM: 8.5% inhibition for form Lf, 10.5% inhibition for form R2, form R1 not inhibited
N6-isopentenyladenosine
-
inhibition between 28.6% and 36.7% for forms R1, R2 and Lf at 0.2 mM
trans-6-(4-hydroxy-3-methyl-2-butenylamino)-9-beta-D-ribofuranosylpurine
-
70% inhibition at 0.5 mM
zeatin riboside
-
competitive inhibition between 32% and 25% for forms R1, R2 and Lf at 0.2 mM
adenine
-
enzyme II inhibited at 0.2 mM, enzymes I and III not inhibited up to 1 mM
N6-Benzyladenosine
-
36.5% inhibition for form R1, 1.6% for form R2, form Lf not inhibited at 0.2 mM
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
4.7
5
-
same activity in Tris or phosphate buffer, no requirement for inorganic phosphate
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY