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physiological function
hyperleptinemia equally suppresses the food intake in wild-type and Hsl KO mice. Leptin-mediated fat loss and glucose-lowering are significantly blunted in the absence of HSL when leptin is overexpressed by recombinant adenovirus carrying leptin. Hsl KO mice have a tendency to retain more fat than wild-type mice in the face of hyperleptinemia
malfunction
-
depletion of the enzyme affects lipoprotein-derived cellular cholesterol influx, diminishes the supply of cholesterol to the mitochondria, and results in the repression of steroidogenic acute regulatory protein and phospho-steroidogenic acute regulatory protein levels
malfunction
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enzyme-deficient mice accumulate sn-1,3-diacylglycerol and sn-2,3-diacylglycerol in white adipose tissue
malfunction
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in male mice, deficiency of hormone sensitive lipase causes deficient spermatogenesis, azoospermia, and infertility
physiological function
-
hormone-sensitive lipase modulates adipose metabolism by providing intrinsic ligands or pro-ligands for PPARgama, mechanism, overview
physiological function
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the catalytic function of hormone-sensitive lipase is essential for spermatogenesis in male mice, while the presence of the enzyme's N-terminal testis-specific fragment is not essential
physiological function
-
the enzyme is crucial for the hydrolysis of diacylglycerol within the lipolytic cascade
physiological function
-
the enzyme is primarily involved in catalyzing cholesteryl ester hydrolysis and plays an important role in the regulation of cAMP-mediated steroidogenic acute regulatory protein expression and steroidogenesis through modulation of liver X receptor pathways. The enzyme-dependent regulation of steroidogenesis predominantly involves liver X recetor signaling. Enzyme-mediated steroidogenesis entails enhanced oxysterol production. Hormonal control of the enzyme activity is primarily mediated by the phosphorylation of serine residues, Ser563, Ser659, and Ser660
physiological function
-
adipose triglyceride lipase Atgl and hormone-sensitive lipase Hsl mRNA expression is time-dependently increased by fasting, along with other fatty acid metabolism genes (Pparx02, Cd36, and Aox). ATGL and HSL protein levels are induced by 239 and 322%, respectively. There is an increase in ATGL phosphorylation at the AMPK-regulated serine 406 site in the 14-3-3 binding motif, and an increase in HSL phosphorylation at serines 565 and 660 that are regulated by AMPK and PKA, respectively
additional information
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hormone-sensitive lipase is significantly increased in white adipose tissue of fasted JunB-KO mice, after JunB silencing through knockdown via lentiviruses harboring a shRNA construct targeted against JunB, the effect might be due to a systemic effect/factor in JunB-KO mice, like the significantly decreased insulin levels, metbaolic phenotype, overview
additional information
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cells deficient in liver X receptors exhibit decreased enzyme responsiveness
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Yeaman, S.J.
Hormone-sensitive lipase - new roles for an old enzyme
Biochem. J.
379
11-22
2004
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Shih, M.F.; Taberner, P.V.
Effects of acute and chronic ethanol administration on the response of mouse adipose tissue hormone-sensitive lipase to alpha(2)-adrenoceptor activation bu UK 14304
Alcohol Alcohol.
36
381-387
2001
Mus musculus
brenda
Haemmerle, G.; Zimmermann, R.; Zechner, R.
Letting lipids go: hormone-sensitive lipase
Curr. Opin. Lipidol.
14
289-297
2003
Mus musculus
brenda
Osterlund, T.
Structure-function relationships of hormone-sensitive lipase
Eur. J. Biochem.
268
1899-1907
2001
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Kraemer, F.B.; Shen, W.J.; Harada, K.; Patel, S.; Osuga, J.I.; Ishibashi, S.; Azhar, S.
Hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis
Mol. Endocrinol.
18
549-557
2004
Mus musculus
brenda
Mottillo, E.P.; Shen, X.J.; Granneman, J.G.
Role of hormone-sensitive lipase in beta-adrenergic remodeling of white adipose tissue
Am. J. Physiol. Endocrinol. Metab.
293
E1188-E1197
2007
Mus musculus (P54310)
brenda
Shen, W.J.; Liang, Y.; Wang, J.; Harada, K.; Patel, S.; Michie, S.A.; Osuga, J.; Ishibashi, S.; Kraemer, F.B.
Regulation of hormone-sensitive lipase in islets
Diabetes Res. Clin. Pract.
75
14-26
2007
Mus musculus
brenda
Miyoshi, H.; Souza, S.C.; Zhang, H.H.; Strissel, K.J.; Christoffolete, M.A.; Kovsan, J.; Rudich, A.; Kraemer, F.B.; Bianco, A.C.; Obin, M.S.; Greenberg, A.S.
Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms
J. Biol. Chem.
281
15837-15844
2006
Mus musculus
brenda
Schweiger, M.; Schreiber, R.; Haemmerle, G.; Lass, A.; Fledelius, C.; Jacobsen, P.; Tornqvist, H.; Zechner, R.; Zimmermann, R.
Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism
J. Biol. Chem.
281
40236-40241
2006
Mus musculus
brenda
Ueno, M.; Suzuki, J.; Zenimaru, Y.; Takahashi, S.; Koizumi, T.; Noriki, S.; Yamaguchi, O.; Otsu, K.; Shen, W.J.; Kraemer, F.B.; Miyamori, I.
Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice
Am. J. Physiol. Endocrinol. Metab.
294
E1109-E1118
2008
Mus musculus, Mus musculus C57BL/6
brenda
Tazoe, F.; Yagyu, H.; Okazaki, H.; Igarashi, M.; Eto, K.; Nagashima, S.; Inaba, T.; Shimano, H.; Osuga, J.; Ishibashi, S.
Induction of ABCA1 by overexpression of hormone-sensitive lipase in macrophages
Biochem. Biophys. Res. Commun.
376
111-115
2008
Mus musculus
brenda
Larsson, S.; Wierup, N.; Sundler, F.; Eliasson, L.; Holm, C.
Lack of cholesterol mobilization in islets of hormone-sensitive lipase deficient mice impairs insulin secretion
Biochem. Biophys. Res. Commun.
376
558-562
2008
Mus musculus
brenda
Fex, M.; Haemmerle, G.; Wierup, N.; Dekker-Nitert, M.; Rehn, M.; Ristow, M.; Zechner, R.; Sundler, F.; Holm, C.; Eliasson, L.; Mulder, H.
A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis
Diabetologia
52
271-280
2009
Mus musculus (P54310), Mus musculus
brenda
Sekiya, M.; Osuga, J.; Yahagi, N.; Okazaki, H.; Tamura, Y.; Igarashi, M.; Takase, S.; Harada, K.; Okazaki, S.; Iizuka, Y.; Ohashi, K.; Yagyu, H.; Okazaki, M.; Gotoda, T.; Nagai, R.; Kadowaki, T.; Shimano, H.; Yamada, N.; Ishibashi, S.
Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis
J. Lipid Res.
49
1829-1838
2008
Mus musculus
brenda
Shen, W.J.; Yu, Z.; Patel, S.; Jue, D.; Liu, L.F.; Kraemer, F.B.
Hormone-sensitive lipase modulates adipose metabolism through PPARgamma
Biochim. Biophys. Acta
1811
9-16
2011
Mus musculus, Mus musculus C57/BL6J
brenda
Kawasaki, M.; Miura, Y.; Yagasaki, K.
Effects of sulfur amino acids, L-methionine, L-cystine and L-cysteine on lipoprotein lipase and hormone-sensitive lipase in differentiated mouse 3T3-L1 adipocytes
Cytotechnology
62
225-233
2010
Mus musculus
brenda
Pinent, M.; Prokesch, A.; Hackl, H.; Voshol, P.J.; Klatzer, A.; Walenta, E.; Panzenboeck, U.; Kenner, L.; Trajanoski, Z.; Hoefler, G.; Bogner-Strauss, J.G.
Adipose triglyceride lipase and hormone-sensitive lipase are involved in fat loss in JunB-deficient mice
Endocrinology
152
2678-2689
2011
Mus musculus
brenda
Wang, S.P.; Wu, J.W.; Bourdages, H.; Lefebvre, J.F.; Casavant, S.; Leavitt, B.R.; Labuda, D.; Trasler, J.; Smith, C.E.; Hermo, L.; Mitchell, G.A.
The catalytic function of hormone-sensitive lipase is essential for fertility in male mice
Endocrinology
155
3047-3053
2014
Mus musculus
brenda
Eichmann, T.O.; Kumari, M.; Haas, J.T.; Farese, R.V.; Zimmermann, R.; Lass, A.; Zechner, R.
Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases
J. Biol. Chem.
287
41446-41457
2012
Mus musculus, Mus musculus C57BL/6
brenda
Manna, P.R.; Cohen-Tannoudji, J.; Counis, R.; Garner, C.W.; Huhtaniemi, I.; Kraemer, F.B.; Stocco, D.M.
Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein
J. Biol. Chem.
288
8505-8518
2013
Mus musculus, Mus musculus MA-10
brenda
Marvyn, P.M.; Bradley, R.M.; Button, E.B.; Mardian, E.B.; Duncan, R.E.
Fasting upregulates adipose triglyceride lipase and hormone-sensitive lipase levels and phosphorylation in mouse kidney
Biochem. Cell Biol.
93
262-267
2015
Mus musculus
brenda
Takanashi, M.; Taira, Y.; Okazaki, S.; Takase, S.; Kimura, T.; Li, C.C.; Xu, P.F.; Noda, A.; Sakata, I.; Kumagai, H.; Ikeda, Y.; Iizuka, Y.; Yahagi, N.; Shimano, H.; Osuga, J.I.; Ishibashi, S.; Kadowaki, T.; Okazaki, H.
Role of hormone-sensitive lipase in leptin-promoted fat loss and glucose lowering
J. Artheroscler. Thromb.
24
110-1116
2017
Mus musculus (P54310)
brenda