EC Number   |
Expression |
Reference |
|---|
    3.1.1.79 | down |
infection by live Mycobacterium leprae significantly suppresses the enzyme expression levels. This suppression is not observed with dead Mycobacterium leprae or latex bead controls |
730333 |
| 3.1.1.79 | down |
tumor necrosis factor-alpha suppresses the enzyme |
714794 |
| 3.1.1.79 | more |
characterization of a 1.224 kb 5'-flanking region of ovine HSL: TATA-less promoter area, harboring several cis-regulatory elements. Strong promoter activities are unambiguously detected, using a -140/+18 nucleotide sequence |
703845 |
| 3.1.1.79 | more |
isoforms HslB1 and HslB2 result from alternative exon usage. Both HSLb2 and HSLb1 mRNAs are expressed in a wide range of tissues. Incubation of hepatocytes with insulin in vitro reduces the mRNA levels of HslB2 rather than HslB1 |
750567 |
| 3.1.1.79 | up |
activation of the protein kinase A pathway, by a cAMP analogue dibutyryl cyclic AMP, enhances expression of the enzyme and its phosphorylation at Ser660 and Ser563, but not at Ser565, concomitant with increased enzyme activity. An increase in enzyme is correlated with the liver X receptor target genes, steroid receptor element-binding protein 1c, and ATP binding cassette transporter A1 |
-, 730033 |
| 3.1.1.79 | up |
gene expression is notably enhanced in the adipose tissue during the fasting period, when lipolysis is highly increased in ruminant species |
703845 |
| 3.1.1.79 | up |
short term fasting over 4 weeks increases HSL1 and HSL2 mRNA expression in the adipose tissue, but only HSL1 mRNA levels increase in the liver and the red muscle. During a prolonged fast of 6 weeks, there is continued elevation of HSL1 and HSL2 mRNA levels in the liver and muscle, HSL mRNA expression in mesenteric fat declines, coincident with depletion of mesenteric fat mass. The upregulations are reversible |
714766 |
