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Literature summary for 3.1.1.79 extracted from

  • Tanigawa, K.; Degang, Y.; Kawashima, A.; Akama, T.; Yoshihara, A.; Ishido, Y.; Makino, M.; Ishii, N.; Suzuki, K.
    Essential role of hormone-sensitive lipase (HSL) in the maintenance of lipid storage in Mycobacterium leprae-infected macrophages (2012), Microb. Pathog., 52, 285-291.
    View publication on PubMed

Application

Application Comment Organism
diagnostics monitoring of enzyme mRNA levels in slit-skin smear specimens from patients with lepromatous and borderline leprosy may be a useful indicator of patient prognosis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
Homo sapiens
-
THP-1 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
HSL
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens infection by live Mycobacterium leprae significantly suppresses the enzyme expression levels. This suppression is not observed with dead Mycobacterium leprae or latex bead controls down

General Information

General Information Comment Organism
malfunction enzyme expression is abolished in the slit-skin smear specimens from patients with lepromatous and borderline leprosy caused by Mycobacterium leprae, which suppresses lipid degradation through inhibition of enzyme expression Homo sapiens
physiological function key enzyme in fatty acid mobilization and lipolysis Homo sapiens