Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.7.7.43 - N-acylneuraminate cytidylyltransferase and Organism(s) Danio rerio and UniProt Accession H9BFW7

for references in articles please use BRENDA:EC2.7.7.43
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
Acts on N-acetyl- and N-glycolyl- derivatives.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Danio rerio
UNIPROT: H9BFW7
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Danio rerio
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
cmp-sialic acid synthetase, cmp-neu5ac synthetase, cmp-neuac synthetase, cmp-n-acetylneuraminic acid synthetase, cmp-neunac synthetase, nmcss, cmp-sia synthetase, dmcss, cmp-sia-syn, dmcsas, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acylneuraminate cytidyltransferase
-
-
-
-
CMP sialate pyrophosphorylase
-
-
-
-
CMP-N-acetylneuraminate synthase
-
-
-
-
CMP-N-acetylneuraminate synthetase
-
-
-
-
CMP-N-acetylneuraminic acid synthase
-
-
-
-
CMP-N-acetylneuraminic acid synthetase
-
-
-
-
CMP-NANA synthetase
-
-
-
-
CMP-Neu5Ac synthetase
-
-
-
-
CMP-NeuAc synthetase
-
-
-
-
CMP-NeuNAc synthetase
-
-
-
-
CMP-Sia synthetase
-
-
-
-
CMP-sialate synthase
-
-
-
-
CMP-sialate synthetase
-
-
-
-
CMP-sialic acid synthetase
-
-
-
-
CMP-sialic synthetase
-
-
-
-
CMPsialate pyrophosphorylase
-
-
-
-
CMPsialate synthase
-
-
-
-
cytidine 5'-monophospho-N-acetylneuraminic acid synthetase
-
-
-
-
cytidine 5'-monophosphosialic acid synthetase
-
-
-
-
cytidine 5-monophosphate N-acetylneuraminic acid synthetase
-
-
-
-
cytidine monophosphate-N-acetylneuraminic acid synthetase
-
-
-
-
cytidine monophospho-sialic acid synthetase
-
-
-
-
cytidine monophosphoacetylneuraminic synthetase
-
-
-
-
cytidine monophosphosialate pyrophosphorylase
-
-
-
-
cytidine monophosphosialate synthetase
-
-
-
-
cytidyltransferase, acylneuraminate
-
-
-
-
cytidylyltransferase, acetylneuraminate
-
-
-
-
sialate cytidylyltransferase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
CTP:N-acylneuraminate cytidylyltransferase
Acts on N-acetyl- and N-glycolyl- derivatives.
CAS REGISTRY NUMBER
COMMENTARY hide
9067-82-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CTP + 5-deaminoneuraminate
diphosphate + CMP-5-deaminoneuraminate
show the reaction diagram
-
-
-
?
CTP + N-acetyl-neuraminate
diphosphate + CMP-N-acetylneuraminate
show the reaction diagram
-
-
-
?
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
show the reaction diagram
-
-
-
?
CTP + 5-deaminoneuraminate
diphosphate + CMP-5-deaminoneuraminate
show the reaction diagram
-
-
-
?
CTP + N-acetyl-neuraminate
diphosphate + CMP-N-acetylneuraminate
show the reaction diagram
-
-
-
?
CTP + N-glycolylneuraminate
diphosphate + CMP-N-glycolylneuraminate
show the reaction diagram
-
-
-
?
additional information
?
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.2
substrate N-glycolylneuraminate, pH 7.5, temperature not specified in the publication
3.3
substrate 5-deaminoneuraminate, pH 7.5, temperature not specified in the publication
0.3
substrate 5-deaminoneuraminate, pH 7.5, temperature not specified in the publication
2.7
substrate N-glycolylneuraminate, pH 7.5, temperature not specified in the publication
4.5
substrate N-acetylneuraminate, pH 7.5, temperature not specified in the publication
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
isoform Cmas2
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
during the pharyngula stage, expression is restricted to the brain
Manually annotated by BRENDA team
more or less ubiquitously expressed from the end of gastrula through segmentation
Manually annotated by BRENDA team
robust expression in the entire central nervous system, the somites, the notochord, and the developing pronephric duct
Manually annotated by BRENDA team
robust expression in the entire central nervous system, the somites, the notochord, and the developing pronephric duct
Manually annotated by BRENDA team
robust expression in the entire central nervous system, the somites, the notochord, and the developing pronephric duct
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NEUAB_DANRE
423
0
47665
Swiss-Prot
Mitochondrion (Reliability: 4)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
193400
gel filtration
49600
4 * 49600, calculated
236100
gel filtration
48200
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tetramer
4 * 49600, calculated
pentamer
or tetramer, 5 * 48200, calculated
tetramer
or pentamer, 4 * 48200, calculated
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
transfection of NIH-3T3 and EPC cells
transfection of NIH-3T3 and EPC cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schaper, W.; Bentrop, J.; Ustinova, J.; Blume, L.; Kats, E.; Tiralongo, J.; Weinhold, B.; Bastmeyer, M.; Muenster-Kuehnel, A.K.
Identification and biochemical characterization of two functional CMP-sialic acid synthetases in Danio rerio
J. Biol. Chem.
287
13239-13248
2012
Danio rerio (H9BFW7), Danio rerio (Q0E671), Danio rerio
Manually annotated by BRENDA team