EC Number   |
Protein Variants |
Reference |
|---|
    2.7.7.43 | D209A |
almost complete loss of activity. Residue involved in metal binding |
722232 |
| 2.7.7.43 | D209A |
the mutation is detrimental to enzyme function |
760608 |
| 2.7.7.43 | D211A |
dramatic loss of activity. Residue involved in metal binding |
722232 |
| 2.7.7.43 | D211A |
the mutation is detrimental to enzyme function |
760608 |
| 2.7.7.43 | DELTA1-227 |
mutant enzyme shows no CMP-N-acetylneuraminic acid synthetase activity, mutant enzyme is able to hydrolyze platelet activating factor |
-, 662202 |
| 2.7.7.43 | DELTA1-229 |
mutant enzyme shows no CMP-N-acetylneuraminic acid synthetase activity, mutant enzyme is not able to hydrolyze platelet activating factor |
662202 |
| 2.7.7.43 | DELTA230-418 |
mutant enzyme shows 43% of the wild-type activity with CTP and N-acylneuraminate as substrates, decrease in stability compared to wild-type enzyme |
662202 |
| 2.7.7.43 | DELTA247-418 |
mutant enzyme shows 15% of the wild-type activity with CTP and N-acylneuraminate as substrates, decrease in stability compared to wild-type enzyme |
662202 |
| 2.7.7.43 | DELTA340-418 |
mutant enzyme shows 65% of the wild-type activity with CTP and N-acylneuraminate as substrates, as stable as wild-type enzyme |
-, 662202 |
| 2.7.7.43 | DELTA384-418 |
mutant enzyme shows 31% of the wild-type activity with CTP and N-acylneuraminate as substrates, as stable as wild-type enzyme |
-, 662202 |
