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Information on EC 2.7.3.2 - creatine kinase and Organism(s) Mus musculus and UniProt Accession Q04447
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2.7.3.2 creatine kinaseIUBMB Comments
N-Ethylglycocyamine can also act as acceptor.
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- 2.7.3.2
- myocardial
- cardiac
- infarct
- coronary
- artery
- ventricular
- troponin
- ischemia
- muscular
-
reperfusion
- pain
- myopathy
- aminotransferase
- necrosis
- myoglobin
- rhabdomyolysis
-
admission
-
admitted
- dystrophy
- chest
-
cytokeratins
-
postoperative
-
cardioprotective
-
alt
-
hemodynamic
-
ejection
-
fatigue
-
percutaneous
-
c-reactive
- angina
- soreness
-
thrombolysis
-
angioplasty
-
electrocardiograph
- myalgia
-
st-segment
- arrhythmia
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exercise-induced
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echocardiography
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cardiopulmonary
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eccentric
-
langendorff
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athlete
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duchenne
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electromyography
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angiographic
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perioperative
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in-hospital
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revascularization
- diagnostics
- biotechnology
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reperfused
- medicine
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
ck, creatine kinase, ck-mb, creatine phosphokinase, creatine kinase-mb, creatinine kinase, creatine kinase mb, ck-bb, plasma creatine kinase, mitochondrial creatine kinase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
adenosine triphosphate-creatine transphosphorylase
-
-
-
-
ATP:creatine phosphotransferase
-
-
-
-
BB-CK
-
-
-
-
CK
-
-
-
-
CK-BB
-
-
-
-
CK-MB
-
-
-
-
CK-MM
-
-
-
-
CKMiMi
-
-
-
-
creatine phosphokinase
-
-
-
-
creatine phosphotransferase
-
-
-
-
kinase, creatine (phosphorylating)
-
-
-
-
MB-CK
-
-
-
-
Mi-CK
-
-
-
-
MiMi-CK
-
-
-
-
MM-CK
phosphocreatine kinase
-
-
-
-
MM-CK
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:creatine N-phosphotransferase
N-Ethylglycocyamine can also act as acceptor.
CAS REGISTRY NUMBER
COMMENTARY
9001-15-4
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + creatine
ADP + phosphocreatine
the mitochondrial isozyme MtCK catalyzes the almost complete transphosphorylation of mitochondrial ATP and cytosolic creatine into ADP and phophocreatine. ADP locally generated by MtCK is transferred into the matrix for rephosphorylation and phosphocreatine is released from mitochondria into the cytosol, direct channelling of ATP and ADP between mitochondrial matrix and MtCK via adenine nucleotide transporter
-
-
r
additional information
?
-
membrane proteins VAMP2/3 and JWA are putative BCK interaction partners. At the plasma membrane, BCK interacts with at least two members of the family of cation-coupled chloride transporters (solute carrier family 12): the K+/Cl- cotransporters 2 (KCC2 or SLC12A5) and 3 (KCC3 or SLC12A6), BCK may be required for maximal phosphorylation efficiency
-
-
?
additional information
?
-
membrane proteins VAMP2/3 and JWA are putative BCK interaction partners. At the plasma membrane, BCK interacts with at least two members of the family of cation-coupled chloride transporters (solute carrier family 12): the K+/Cl- cotransporters 2 (KCC2 or SLC12A5) and 3 (KCC3 or SLC12A6), BCK may be required for maximal phosphorylation efficiency
-
-
?
additional information
?
-
the enzyme binds to 1,2-dipalmitoyl-sn-glycero-3-phosphate with the highest affinity (dissociation constant: 0.002 mM)
-
-
-
additional information
?
-
-
the enzyme binds to 1,2-dipalmitoyl-sn-glycero-3-phosphate with the highest affinity (dissociation constant: 0.002 mM)
-
-
-
additional information
?
-
the enzyme binds to 1,2-dipalmitoyl-snglycero-3-phosphate with the highest affinity (dissociation constant 0.002 mM). The enzyme preferentially interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids, but not with polyunsaturated fatty acid-containing phosphatidic acids
-
-
-
additional information
?
-
-
the enzyme binds to 1,2-dipalmitoyl-snglycero-3-phosphate with the highest affinity (dissociation constant 0.002 mM). The enzyme preferentially interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids, but not with polyunsaturated fatty acid-containing phosphatidic acids
-
-
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + creatine
ADP + phosphocreatine
the mitochondrial isozyme MtCK catalyzes the almost complete transphosphorylation of mitochondrial ATP and cytosolic creatine into ADP and phophocreatine. ADP locally generated by MtCK is transferred into the matrix for rephosphorylation and phosphocreatine is released from mitochondria into the cytosol, direct channelling of ATP and ADP between mitochondrial matrix and MtCK via adenine nucleotide transporter
-
-
r
additional information
?
-
membrane proteins VAMP2/3 and JWA are putative BCK interaction partners. At the plasma membrane, BCK interacts with at least two members of the family of cation-coupled chloride transporters (solute carrier family 12): the K+/Cl- cotransporters 2 (KCC2 or SLC12A5) and 3 (KCC3 or SLC12A6), BCK may be required for maximal phosphorylation efficiency
-
-
?
additional information
?
-
membrane proteins VAMP2/3 and JWA are putative BCK interaction partners. At the plasma membrane, BCK interacts with at least two members of the family of cation-coupled chloride transporters (solute carrier family 12): the K+/Cl- cotransporters 2 (KCC2 or SLC12A5) and 3 (KCC3 or SLC12A6), BCK may be required for maximal phosphorylation efficiency
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
Mg2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Acrylamide
-
significantly inactivate screatine kinase and glutathione S-transferase and deplete glutathione. When the dietary constituents, tea polyphenols, resveratrol, and diallyl trisulfide are cotreated with acrylamide, all of them can effectively recover the activities of creatine kinase
morphine
0.00001-0.1 mM morphine significantly reduces recombinant enzymatic activity (27% inhibition at 0.001 mM, 80% inhibition at more than 0.05 mM)
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
3.26
Creatine
-
enzyme from embryonic stem cell-derived cardiomyocytes, pH 6.5, 37°C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
-
comparison of kinetic constants with enzymes from Danio rerio, Lampetra japonica, Neanthes diversicolor, Dendronephthya gigantea
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
45
-
both for enzyme from embryonic stem cell-derived cardiomyocytes and from neonatal cardiomyocytes
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
in cultured mouse myotubes, BCK localizes near the endings of the cells, interaction with skeletal and cardiac alpha-actin
parietal cells of the stomach, BCK is co-localizing with and fueling the gastric H+/K+-ATPase pump at the apical membrane and the membranes of the tubulovesicular system
-
phenylbutyrate greatly decreases the adriamycin-associated elevations of serum lactate dehydrogenase and creatine kinase activities, two nonspecific widely used cardiac injury markers
additional information
cytosolic brain-type creatine kinase, the CK energy buffering and shuttle system seems to operate in many brain cells, in particular in the polarized large cells like neurons or hair bundle and photoreceptor cells in the sensory organs
primary cortical neurons from mutant R6/2 mice and wild-type B6CBAFI/J mice
additional information
in a given cell type, at least one dimeric cytosolic isoform is always co-expressed with a predominantly octameric mitochondrial isoform (MtCK), generally cytosolic muscle-type CK (MCK) with sarcomeric MtCK (sMtCK), or cytosolic brain-type CK (BCK) with ubiquitous MtCK
additional information
in a given cell type, at least one dimeric cytosolic isoform is always co-expressed with a predominantly octameric mitochondrial isoform (MtCK), generally cytosolic muscle-type CK (MCK) with sarcomeric MtCK (sMtCK), or cytosolic brain-type CK (BCK) with ubiquitous MtCK
additional information
in a given cell type, at least one dimeric cytosolic isoform is always co-expressed with a predominantly octameric mitochondrial isoform (MtCK), generally cytosolic muscle-type CK (MCK) with sarcomeric MtCK (sMtCK), or cytosolic brain-type CK (BCK) with ubiquitous MtCK
additional information
in a given cell type, at least one dimeric cytosolic isoform is always co-expressed with a predominantly octameric mitochondrial isoform (MtCK), generally cytosolic muscle-type CK (MCK) with sarcomeric MtCK (sMtCK), or cytosolic brain-type CK (BCK) with ubiquitous MtCK
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
recruitment of BCK to submembrane domains, formation of dynamic actin-based protrusions
association of brain-type creatine kinase with membrane structures such as synaptic vesicles and mitochondria, involving hydrophobic and electrostatic interactions, respectively. Membrane localization of BCK seems to be an important and regulated feature for the fueling of membrane-located, ATP-dependent processes, stressing again the importance of local rather than global ATP concentrations. Recruitment of BCK to submembrane domains also supports formation of dynamic actin-based protrusions
association with by brain-type creatine kinase
additional information
octameric MtCK is situated in the mitochondrial intermembrane space, binding simultaneously to both mitochondrial inner and outer membranes, as well as in the cristae space bound to inner membrane
additional information
the BCK isoform is mostly soluble but partially associates with cellular structures, subcellular localizations and cellular interaction partners of BCK, overview
-
additional information
the BCK isoform is mostly soluble but partially associates with cellular structures, subcellular localizations and cellular interaction partners of BCK, overview
-
additional information
the mitochondrial enzyme participates in large complexes that include the voltage-dependent anion channel in the mitochondrial outer membrane as well as cardiolipin and adenine nucleotide transporter in the mitochondrial inner membrane, localization and complex formation of MtCK, overview
-
additional information
the mitochondrial enzyme participates in large complexes that include the voltage-dependent anion channel in the mitochondrial outer membrane as well as cardiolipin and adenine nucleotide transporter in the mitochondrial inner membrane, localization and complex formation of MtCK, overview
-
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
metabolism
co-localization and functional coupling of creatine kinase isoforms with ATP-producing and ATP-consuming reactions, a non-equilibrium state of the creatine kinase reaction, and restricted intracellular diffusion of adenine nucleotides support the concept of a cellular CK/PCr phosphoryl transfer network. The reactions catalyzed by different isoforms of compartmentalized creatine kinase, organized in intracellular energetic units tend to maintain the intracellular metabolic stability
physiological function
malfunction
metabolism
physiological function
additional information
malfunction
downregulation of brain-type creatine kinase in brain of a Huntington's disease mouse model. Huntington's disease is a hereditary neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Mutant HTT (mHTT) suppresses the activity of the CKB gene promoter, which contributes to the lowered CKB expression in Huntington's disease. Exogenous expression of wild-type CKB, but not a dominant negative CKB mutant, rescues the ATP depletion, aggregate formation, impaired proteasome activity, and shortened neurites induced by mHTT. Negative regulation of isozyme CKB by mHTT is a key event in the pathogenesis of Huntington's disease and contributes to the neuronal dysfunction associated with Huntington's disease
malfunction
knockout mice that lack the brain CK isoforms, i.e. BCK and/or ubiquitous MtCK, uMtCK, show defects in spatial memory acquisition and behavior, development of the hippocampus, correct functioning of hair bundle cells in the auditory system, and energy distribution within photoreceptor cells, transgenic models of creatine deficiency, overview
physiological function
brain-type creatine kinase is an enzyme involved in energy homeostasis via the phosphocreatine-creatine kinase system, the CK system plays a critical role in energy homeostasis and ATP distribution. Creatine kinase activity is critical for the beneficial effects of isozyme CKB of enhancing proteasome activity and reducing aggregate formation
physiological function
creatine kinase is a key player in maintaining cellular energy homeostasis using creatine for reversible phosphoryl transfer between ATP and phosphocreatine. The cellular energy sensor AMP-activated protein kinase (AMPK) is able to phosphorylate brain-type cratine kinase at serine 6 to trigger BCK localization at the endoplasmic reticulum, in close vicinity of the highly energy-demanding Ca2+ ATPase pump. Membrane localization of BCK seems to be an important and regulated feature for the fueling of membrane-located, ATP-dependent processes, stressing again the importance of local rather than global ATP concentrations. Creatine kinase microcompartments play a role in the energy metabolism. At the cellular level, creatine kinase acts mainly via two different mechanisms. Firstly, the enzyme enables the building-up of a global cellular energy buffer in the form of a large phosphocreatine pool that can be used to regenerate ATP during a temporal mismatch between ATP generation and consumption. Secondly, cytosolic and mitochondrial isozymes, together with highly concentrated and diffusible phosphocreatine, facilitate the so-called CK/PCr shuttle to correct for a spatial mismatch between ATP generation and -consumption within a cell. The CK/PCr shuttle is particularly important for large and polar cells with high and/or fluctuating energy demands such as skeletal and heart muscle cells, or many cell types in the brain, but may occur in any cell type expressing creatine kinase. BCK may fuel the endoplasmic reticulum Ca2+ ATPase pump. In retina photoreceptor cells, BCK may play an equally important role, but rather in synaptic transmission at the synaptic terminal or for cGMP resynthesis in the rod outer segments. In astrocytes and fibroblasts, BCK in peripheral cellular structures facilitates actin-driven cell spreading and migration
malfunction
-
absence of creatine kinase in muscle cells leads to morphological and functional adaptations towards preservation of muscle contractile abilities
malfunction
-
complete brain-type creatine kinase deficiency in mice blocks seizure activity and affects intracellular calcium kinetics
malfunction
-
oxygen consumption dynamics during electrical stimulation in superfused fast-twitch hindlimb muscles isolated from wild-type and transgenic mice deficient in the myoplasmic and mitochondrial creatine isoforms (MiM CK-/-), respectively. Transgenic mice deficient in the mitochondrial creatinine isoforms (MiM CK-/-) show muscle oxygen consumption activation kinetics 30% faster than wild-type. MiM CK-/- muscle oxygen consumption deactivation kinetics are 380% faster than wild-type
malfunction
-
24 h after trauma brain injury (TBI) of mice preconditioned with N-methyl-D-aspartate, creatine kinase activity is augmented in the cerebral cortex. Eventhough N-methyl-D-aspartate preconditioning and TBI have similar effects on the enzyme activity, each manages its response via opposite mechanisms because the protective effects of preconditioning are unambiguous
malfunction
knockout mice that lack the brain CK isoforms, i.e. BCK and/or ubiquitous MtCK, uMtCK, show defects in spatial memory acquisition and behavior, development of the hippocampus, correct functioning of hair bundle cells in the auditory system, and energy distribution within photoreceptor cells, transgenic models of creatine deficiency, overview
metabolism
importance of functional coupling between MtCK, ANT and respiration/ATP synthesis provided by the close co-localization of MtCK and ANT in proteolipid complexes. Co-localization and functional coupling of creatine kinase isoforms with ATP-producing and ATP-consuming reactions, a non-equilibrium state of the creatine kinase reaction, and restricted intracellular diffusion of adenine nucleotides support the concept of a cellular CK/PCr phosphoryl transfer network. The reactions catalyzed by different isoforms of compartmentalized creatine kinase, organized in intracellular energetic units tend to maintain the intracellular metabolic stability
metabolism
the enzyme preferentially interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids, but not with polyunsaturated fatty acid-containing phosphatidic acids. Notably, the enzyme exclusively interacts with phosphatidic acid, whereas the protein does not bind to other lipids such as diacylglycerol, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, phosphatidylinositol (3,4,5)-triphosphate and cardiolipin
physiological function
-
creatine kinase catalyzes the reversible transfer of the phosphoryl group from phosphocreatine to ADP, regenerating ATP, and it is a major enzyme of higher eukaryotes that manages high, fluctuating energy demands to maintain cellular energy homeostasis and guarantee stable, locally buffered ATP/ADP ratios
physiological function
creatine kinase is a key player in maintaining cellular energy homeostasis using creatine for reversible phosphoryl transfer between ATP and phosphocreatine. The cellular energy sensor AMP-activated protein kinase (AMPK) is able to phosphorylate brain-type cratine kinase at serine 6 to trigger BCK localization at the endoplasmic reticulum, in close vicinity of the highly energy-demanding Ca2+ ATPase pump. Membrane localization of BCK seems to be an important and regulated feature for the fueling of membrane-located, ATP-dependent processes, stressing again the importance of local rather than global ATP concentrations. Creatine kinase microcompartments play a role in the energy metabolism. At the cellular level, creatine kinase acts mainly via two different mechanisms. Firstly, the enzyme enables the building-up of a global cellular energy buffer in the form of a large phosphocreatine pool that can be used to regenerate ATP during a temporal mismatch between ATP generation and consumption. Secondly, cytosolic and mitochondrial isozymes, together with highly concentrated and diffusible phosphocreatine, facilitate the so-called CK/PCr shuttle to correct for a spatial mismatch between ATP generation and -consumption within a cell. The CK/PCr shuttle is particularly important for large and polar cells with high and/or fluctuating energy demands such as skeletal and heart muscle cells, or many cell types in the brain, but may occur in any cell type expressing creatine kinase. The role of MtCK within the mitochondrial interactosome is to separate energy fluxes from the intracellular energy signals and to amplify these signals due to the intramitochondrial recycling of ADP
additional information
phosphocreatine is an alternative energy carrier that compared to ATP is metabolically inert (except for the creatine kinase reaction), much smaller in molecular size and less charged over the physiological pH range, and is thus significantly more diffusible than ATP
additional information
phosphocreatine is an alternative energy carrier that compared to ATP is metabolically inert (except for the creatine kinase reaction), much smaller in molecular size and less charged over the physiological pH range, and is thus significantly more diffusible than ATP
additional information
phosphocreatine is an alternative energy carrier that compared to ATP is metabolically inert (except for the creatine kinase reaction), much smaller in molecular size and less charged over the physiological pH range, and is thus significantly more diffusible than ATP
additional information
phosphocreatine is an alternative energy carrier that compared to ATP is metabolically inert (except for the creatine kinase reaction), much smaller in molecular size and less charged over the physiological pH range, and is thus significantly more diffusible than ATP
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). KCRB_MOUSE
381
0
42713
Swiss-Prot
other Location (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
the cellular energy sensor AMP-activated protein kinase (AMPK) is able to phosphorylate brain-type cratine kinase at Ser6 to trigger the enzyme's localization at the endoplasmic reticulum, in close vicinity of the highly energy-demanding Ca2+ ATPase pump
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
transgenic mice lacking mitochondrial enzyme or both mitochondrial and cytoplasmic enzyme
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene Ckb, real-time quantitative reverse-transcription enzyme expression analysis. Compared to Neuro-2a cells expressing a control construct, expression of mHTT (109Q) significantly inhibits CKB promoter activity
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
mutant mHTT (109Q) significantly suppresses the activity of the promoter of the CKB gene, which contributes to the lowered CKB expression in Huntington's disease. Exogenous expression of wild-type CKB, but not a dominant negative CKB mutant, rescues the phenotype
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
-
transgenic mice lacking mitochondrial enzyme or both mitochondrial and cytoplasmic enzyme, myocardial energy-recruiting mechanims
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Olson, E.N.; Lathrop, B.K.; Glaser, L.
Purification and cell-free translation of a unique high molecular weight form of the brain isozyme of creatine phosphokinase from mouse
Biochem. Biophys. Res. Commun.
108
715-723
1982
Mus musculus
Ventura-Clapier, R.; Kuznetsov, A.; Veksler, V.; Boehm, E.; Anflous, K.
Functional coupling of creatine kinases in muscles: species and tissue specificity
Mol. Cell. Biochem.
184
231-247
1998
Gallus gallus, Columba livia, Oryctolagus cuniculus, Frog, Mus musculus, Rattus norvegicus
Bonz, A.W.; Kniesch, S.; Hofmann, U.; Kullmer, S.; Bauer, L.; Wagner, H.; Ertl, G.; Spindler, M.
Functional properties and [Ca(2+)](i) metabolism of creatine kinase--KO mice myocardium
Biochem. Biophys. Res. Commun.
298
163-168
2002
Mus musculus
Matsushima, K.; Uda, K.; Ishida, K.; Kokufuta, C.; Iwasaki, N.; Suzuki, T.
Comparison of kinetic constants of creatine kinase isoforms
Int. J. Biol. Macromol.
38
83-88
2006
Danio rerio, Lethenteron camtschaticum, Mus musculus, Hediste diversicolor, Dendronephthya gigantea
Zonouzi, R.; Ashtiani, S.K.; Hosseinkhani, S.; Baharvand, H.
Kinetic properties of extracted lactate dehydrogenase and creatine kinase from mouse embryonic stem cell- and neonatal-derived cardiomyocytes
J. Biochem. Mol. Biol.
39
426-431
2006
Mus musculus
Shin, J.B.; Streijger, F.; Beynon, A.; Peters, T.; Gadzala, L.; McMillen, D.; Bystrom, C.; Van der Zee, C.E.; Wallimann, T.; Gillespie, P.G.
Hair bundles are specialized for ATP delivery via creatine kinase
Neuron
53
371-386
2007
Gallus gallus, Mus musculus
Daosukho, C.; Chen, Y.; Noel, T.; Sompol, P.; Nithipongvanitch, R.; Velez, J.M.; Oberley, T.D.; St Clair, D.K.
Phenylbutyrate, a histone deacetylase inhibitor, protects against Adriamycin-induced cardiac injury
Free Radic. Biol. Med.
42
1818-1825
2007
Mus musculus
Xie, Q.; Liu, Y.; Sun, H.; Liu, Y.; Ding, X.; Fu, D.; Liu, K.; Du, X.; Jia, G.
Inhibition of acrylamide toxicity in mice by three dietary constituents
J. Agric. Food Chem.
56
6054-6060
2008
Mus musculus
Streijger, F.; Scheenen, W.J.; van Luijtelaar, G.; Oerlemans, F.; Wieringa, B.; Van der Zee, C.E.
Complete brain-type creatine kinase deficiency in mice blocks seizure activity and affects intracellular calcium kinetics
Epilepsia
51
79-88
2010
Mus musculus
Tylkova, L.
Architectural and functional remodeling of cardiac and skeletal muscle cells in mice lacking specific isoenzymes of creatine kinase
Gen. Physiol. Biophys.
28
219-224
2009
Mus musculus
Jeneson, J.; Veld, F.; Schmitz, J.; Meyer, R.; Hilbers, P.; Nicolay, K.
Similar mitochondrial activation kinetics in wild-type and creatine kinase-deficient fast-twitch muscle indicate significant Pi control of respiration
Am. J. Physiol. Regul. Integr. Comp. Physiol.
300
1316-1325
2011
Mus musculus
Schlattner, U.; Klaus, A.; Ramirez Rios, S.; Guzun, R.; Kay, L.; Tokarska-Schlattner, M.
Cellular compartmentation of energy metabolism: creatine kinase microcompartments and recruitment of B-type creatine kinase to specific subcellular sites
Amino Acids
48
1751-1774
2016
Rattus norvegicus (P07335), Mus musculus (P30275), Mus musculus (Q04447), Rattus norvegicus Wistar (P07335)
Lin, Y.S.; Cheng, T.H.; Chang, C.P.; Chen, H.M.; Chern, Y.
Enhancement of brain-type creatine kinase activity ameliorates neuronal deficits in Huntingtons disease
Biochim. Biophys. Acta
1832
742-753
2013
Homo sapiens (P12277), Homo sapiens, Mus musculus (Q04447), Mus musculus, Mus musculus R6/2 (Q04447)
Boeck, C.R.; Carbonera, L.S.; Milioli, M.E.; Constantino, L.C.; Garcez, M.L.; Rezin, G.T.; Scaini, G.; Streck, E.L.
Mitochondrial respiratory chain and creatine kinase activities following trauma brain injury in brain of mice preconditioned with N-methyl-D-aspartate
Mol. Cell. Biochem.
384
129-137
2013
Mus musculus, Mus musculus CF-1
Hoshino, F.; Murakami, C.; Sakai, H.; Satoh, M.; Sakane, F.
Creatine kinase muscle type specifically interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids
Biochem. Biophys. Res. Commun.
513
1035-1040
2019
Mus musculus (P07310), Mus musculus
Weinsanto, I.; Mouheiche, J.; Laux-Biehlmann, A.; Delalande, F.; Marquette, A.; Chavant, V.; Gabel, F.; Cianferani, S.; Charlet, A.; Parat, M.O.; Goumon, Y.
Morphine binds creatine kinase B and inhibits its activity
Front. Cell. Neurosci.
12
464
2018
Mus musculus (Q04447), Mus musculus
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