EC Number   |
Inhibitors |
Structure |
|---|
   2.7.3.2 | (2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one |
organotellurium inhibits creatine kinase activity by two different mechanisms: competition with ADP and oxidation of critical sulfhydryl groups for the functioning of the enzyme |
   |
| 2.7.3.2 | 1-anilinonaphthalene-8-sulfonate |
unfolding agent |
|
| 2.7.3.2 | 2,3-butadiene |
complete inhibition, MgATP2- or MgADP- protect the enzyme from inactivation |
|
| 2.7.3.2 | 4,4'-dithiodipyridine |
- |
|
| 2.7.3.2 | 4-hydroxy-2-nonenal |
dose-dependent inhibition of creatine kinase, inhibition correlates with 4-hydroxy-2-nonenal adduct formation on specific amino acid residues including the active site residues H66, H191, C283, and H296 |
|
| 2.7.3.2 | 4-hydroxy-3-nitrophenylglyoxal |
complete inactivation, modification of 2 arginine residues per enzyme subunit, inhibition kinetics at pH 8.7, MgATP2- or MgADP- protect the enzyme from inactivation |
|
| 2.7.3.2 | 4-hydroxymercuribenzoic acid |
- |
|
| 2.7.3.2 | 4-hydroxymercuribenzoic acid |
complete inhibition at 0.01 mM |
|
| 2.7.3.2 | 5,5'-dithiobis(2-nitrobenzoate) |
- |
|
| 2.7.3.2 | 5,5'-dithiobis(2-nitrobenzoate) |
less than 5% residual activity at 0.1 mM |
|
