Ligand Creatine

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Basic Ligand Information

Molecular Structure
Picture of Creatine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H9N3O2
Creatine
DSPRYHPLXXUNHS-XNIJJKJLSA-N


Show all pahtways known for Show all BRENDA pathways known for Creatine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine
show the reaction diagram
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creatine phosphate + H2O = creatine + o-phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (6 results)

Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine
show the reaction diagram
-
ADP + phosphocreatine = ATP + creatine
show the reaction diagram
-
-
creatine phosphate + H2O = creatine + phosphate
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation of creatine kinase and induction of a state 3-like respiration in isolated brain mitochondria, and prevention of H2O2 production obeys the steady-state kinetics of the enzyme to phosphorylate creatine
the enzyme is dependent on creatine
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Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
represses enzyme expression
-
slight
-
inhibition of enzyme form S2, S3 and S4. Slight inhibition of enzyme form S1
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3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (53 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.246
-
-

KM Value (109 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for Creatine

ChEBI
PubChem
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PubChem