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Information on EC 2.7.11.13 - protein kinase C
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2.7.11.13 protein kinase CIUBMB Comments
A family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol. Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell-signalling pathways. Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumour promoters.
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Word Map
- 2.7.11.13
-
phorbol
- pma
- agonist
- phospholipase
- 13-acetate
- 12-myristate
- staurosporine
- diacylglycerols
- camp
- inositol
- endothelial
- phosphatidylinositol
- mapks
- forskolin
-
ionophore
- cyclase
- myristate
-
camp-dependent
- 12-o-tetradecanoylphorbol-13-acetate
- calmodulin
- angiotensin
-
mitogen
-
desensitization
-
arachidonic
-
contractile
-
depolarization
-
receptor-mediated
- synaptic
-
blocker
- prostaglandin
- myocytes
- pertussis
- 3-kinase
-
signal-regulated
- phosphoinositide
- erk
- thapsigargin
- c-fos
- genistein
- wortmannin
-
1,4,5-trisphosphate
-
muscarinic
- endothelin-1
- ionomycin
-
l-type
- carbachol
- sphingosine
- fmlp
-
metabotropic
-
fura-2
- molecular biology
- medicine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
protein kinase c, pkcalpha, pkc-alpha, pkc alpha, pkcepsilon, pkc-delta, pkczeta, pkc-epsilon, pkc delta, pkc-zeta, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
PKCalpha
Calcium-dependent protein kinase C
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-
-
-
epsilonPKC
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-
-
-
PKC
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-
-
-
protein kinase C
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-
-
-
protein kinase-C
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-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (diacylglycerol-dependent)
A family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol. Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell-signalling pathways. Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumour promoters.
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CAS REGISTRY NUMBER
COMMENTARY
141436-78-4
calcium-dependent protein kinase C
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + FKKQGSFAKKK
ADP + phosphorylated FKKQGSFAKKK
highly specific substrate for isozyme PKCalpha relative to other isozymes, 60% phosphorylation rate with isozyme PKCalpha, less than 20% phosphorylation rate with other PKC isozymes
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-
?
ATP + [casein kinase 1 delta]
ADP + phosphorylated casein kinase 1 delta
casein kinase 1 delta is modulated by protein kinase C alpha by site-specific phosphorylation within the kinase domain of CK1delta
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-
?
ATP + casein kinase 1delta
ADP + phosphorylated casein kinase 1delta
mutations T161A, T174A, and T176A in casein kinase 1delta (CK1delta) all result in reduced phosphorylation by PKCalpha. Most significant effects are visible for GST-CK1delta98-178,T161A and GST-CK1delta98-178,T176A with about 55% and 46% reduction compared to wild type, whereas phosphorylation of GST-CK1delta98-178,T174A is only slightly reduced. Mutation S181A in GST-CK1delta178-227,S181A reduces phosphorylation by PKCalpha by 74%, while for S191A in GST-CK1delta178-227,S191A (FP1552) only a minor reduction can be observed. GST-CK1delta227-304,S298A show no clear reduction of PKCalpha-mediated phosphate incorporation
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-
?
ATP + casein kinase 1delta
ADP + phosphorylated casein kinase 1delta
the enzyme phosphorylates the kinase domain of casein kinase 1delta at Ser53, Thr176, and Ser181
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + [casein kinase 1 delta]
ADP + phosphorylated casein kinase 1 delta
casein kinase 1 delta is modulated by protein kinase C alpha by site-specific phosphorylation within the kinase domain of CK1delta
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-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ro-31-7549
specific inhibitor for isozyme PKCalpha
additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
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additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
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additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
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additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
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additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
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additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
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additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
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additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
-
additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
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additional information
-
isozyme PKCalpha is not inhibited by H-89 and rottlerin
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
the activation of PKCalpha isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1)
-
additional information
the activation of PKCalpha isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1)
-
additional information
the activation of PKCalpha isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1)
-
additional information
the activation of PKCalpha isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1)
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Aberrant Crypt Foci
Effect of dietary fat on colonic protein kinase C and induction of aberrant crypt foci.
Aberrant Crypt Foci
Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis.
Aberrant Crypt Foci
Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis.
Aberrant Crypt Foci
Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo.
Abnormalities, Multiple
Ca(2+)-dependent mitogen-activated protein kinase activation in spontaneously hypertensive rat vascular smooth muscle defines a hypertensive signal transduction phenotype.
Acantholysis
Differential coupling of M1 muscarinic and alpha7 nicotinic receptors to inhibition of pemphigus acantholysis.
Acantholysis
In vivo blockade of pemphigus vulgaris acantholysis by inhibition of intracellular signal transduction cascades.
Acidosis
Acidosis enhances translocation of protein kinase C but not Ca(2+)/calmodulin-dependent protein kinase II to cell membranes during complete cerebral ischemia.
Acidosis
Acidosis inhibits gallbladder contraction mediated by protein kinase C activation.
Acidosis
Alpha-adrenergic preservation of myocardial pH during ischemia is PKC isoform dependent.
Acidosis
An acute hyperglycemia or acidosis-induced changes of indolamines level correlates with PKC-alpha expression in rat brain.
Acidosis
Deficient brain RNA polymerase and altered nucleolar structure persists until day 8 after perinatal asphyxia of the rat.
Acidosis
Hyperglycemia and hypercapnia differently affect post-ischemic changes in protein kinases and protein phosphorylation in the rat cingulate cortex.
Acidosis
Influence of CO2 pneumoperitoneum on intracellular pH and signal transduction in cancer cells.
Acidosis
Mice Lacking Protein Kinase C Beta Present Modest Increases in Systolic Blood Pressure and NH(4)Cl-Induced Metabolic Acidosis.
Acidosis
Modulation of sodium-hydrogen exchange activity in cardiac myocytes during acidosis and realkalinisation: effects on calcium, pHi, and cell shortening.
Acidosis
Possible mechanism(s) of arachidonic acid-induced intracellular acidosis in rat cardiac myocytes.
Acidosis
Regulation of apoA1 gene expression with acidosis: requirement for a transcriptional repressor.
Acidosis
Regulatory mechanisms and physiological relevance of a voltage-gated H+ channel in murine osteoclasts: phorbol myristate acetate induces cell acidosis and the channel activation.
Acidosis
Repetitive acidosis protects the ischemic heart: implications for mechanisms in preconditioned hearts.
Acidosis
Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle.
Acidosis
Role of protein kinase C in acidosis induced glial swelling--current understanding.
Acidosis
The cardiac adrenergic system in ischaemia: differential role of acidosis and energy depletion.
Acidosis
The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis.
Acidosis
The sodium-hydrogen exchange system in the heart: its role in ischemic and reperfusion injury and therapeutic implications.
Acidosis, Respiratory
Regulation of renal Na-HCO3 cotransporter: VIII. Mechanism Of stimulatory effect of respiratory acidosis.
Acidosis, Respiratory
Role of protein kinase C in the adaptive increase in Na-H antiporter in respiratory acidosis.
Acne Vulgaris
Anti-inflammatory actions of benzoyl peroxide: effects on the generation of reactive oxygen species by leucocytes and the activity of protein kinase C and calmodulin.
Acquired Immunodeficiency Syndrome
A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity.
Acquired Immunodeficiency Syndrome
Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase C?
Acquired Immunodeficiency Syndrome
Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase C?.
Acquired Immunodeficiency Syndrome
Effect of human immunodeficiency virus type 1 on intracellular activation and superoxide production by neutrophils.
Acquired Immunodeficiency Syndrome
Stimulation of AIDS lymphocytes with calcium ionophore (A23187) and phorbol ester (PMA): studies of cytoplasmic free Ca, IL-2 receptor expression, IL-2 production, and proliferation.
Acquired Immunodeficiency Syndrome
Synthesis and Biological Activities of Simplified Analogs of the Natural PKC Ligands, Bryostatin-1 and Aplysiatoxin.
Acromegaly
Growth hormone secretion in human acromegalic pituitary adenomas: cyclic adenosine monophosphate and protein kinase C responses.
Acromegaly
Markers of function and proliferation in non-invasive and invasive bi- and plurihormonal adenomas of patients with acromegaly: an immunohistochemical study.
Acromegaly
Phorbol ester, not growth hormone releasing factor, consistently stimulates growth hormone release from somatotroph adenomas in culture.
ACTH-Secreting Pituitary Adenoma
Protein Kinase C Delta restrains growth in ACTH-secreting pituitary adenoma cells.
Acute Generalized Exanthematous Pustulosis
Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways.
Acute Kidney Injury
Expression of syndecan-1, PKC and VEGF in rats with acute kidney injury and correlation between syndecan-1 and renal function.
Acute Lung Injury
PICK1 deficiency exacerbates sepsis-associated acute lung injury and impairs glutathione synthesis via reduction of xCT.
Acute Lung Injury
PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury.
Acute Lung Injury
Protein kinase C inhibition attenuates hypochlorite-induced acute lung injury.
Acute Lung Injury
Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury.
Acute Lung Injury
Protein kinase C modulates the pulmonary inflammatory response in acute pancreatitis.
Acute Lung Injury
Protein Kinase C Theta Inhibition Attenuates Lipopolysaccharide-Induced Acute Lung Injury through Notch Signaling Pathway via Suppressing Th17 Cell Response in Mice.
Acute Lung Injury
Protein Kinase C Zeta Inhibitor Promotes Resolution of Bleomycin-induced Acute Lung Injury.
Acute Lung Injury
The protein kinase C inhibitor, H-7, induces acute lung injury in guinea pigs.
Acute Lung Injury
Transient cerebral ischemia/reperfusion-induced acute lung injury in rats associated with protein kinase C alpha expression.
Adenocarcinoma
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Adenocarcinoma
A phospholipase D and protein kinase C inhibitor blocks the spreading of murine mammary adenocarcinoma cells altering f-actin and beta1-integrin point contact distribution.
Adenocarcinoma
Activation of protein kinase C by phorbol esters modulates alpha2beta1 integrin on MCF-7 breast cancer cells.
Adenocarcinoma
Alterations in protein kinase C in 1,2-dimethylhydrazine induced colonic carcinogenesis.
Adenocarcinoma
Assessment of protein kinase C isozymes by enzyme immunoassay and overexpression of type II in thyroid adenocarcinoma.
Adenocarcinoma
CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells.
Adenocarcinoma
Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility.
Adenocarcinoma
Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes.
Adenocarcinoma
Cytoskeletal reorganization induced by retinoic acid treatment of human endometrial adenocarcinoma (RL95-2) cells is correlated with alterations in protein kinase C-alpha.
Adenocarcinoma
Decreased PKC-alpha expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells.
Adenocarcinoma
Dexniguldipine hydrochloride inhibits growth of human pancreatic adenocarcinoma cells and expression of protein kinase C isoforms alpha and zeta.
Adenocarcinoma
Differential effects of phorbol esters on proliferation and calcyclin expression in human endometrial carcinoma cells.
Adenocarcinoma
Down-regulation of protein kinase C activity in 1,2-dimethylhydrazine-induced rat colonic tumors.
Adenocarcinoma
Effects of dietary fish oil and corn oil on protein kinase C distribution in the rat colon with and without 1,2 dimethylhydrazine treatment and in rat colonic adenocarcinoma.
Adenocarcinoma
Epidermal growth factor activates protein kinase C in the human endometrial cancer cell line HEC-1-A.
Adenocarcinoma
Expression of multiple isoforms of protein kinase C in normal human colon mucosa and colon tumors and decreased levels of protein kinase C beta and eta mRNAs in the tumors.
Adenocarcinoma
Expression profile analysis of two antisense lncRNAs to improve prognosis prediction of colorectal adenocarcinoma.
Adenocarcinoma
Functional role of beta-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells.
Adenocarcinoma
Genetic Ablation of PKC Epsilon Inhibits Prostate Cancer Development and Metastasis in Transgenic Mouse Model of Prostate Adenocarcinoma.
Adenocarcinoma
Human pancreatic adenocarcinoma-associated antigens defined by novel murine monoclonal antibodies Pak-1 and Pak-2.
Adenocarcinoma
Inhibition of protein kinase Calpha enhances anticancer agent-induced loss of anchorage-independent growth regardless of protection against apoptosis by Bcl-2.
Adenocarcinoma
Localization of protein kinase C alpha isoform expression in the human gastrointestinal tract.
Adenocarcinoma
Loss of protein kinase C delta isozyme immunoreactivity in human adenocarcinomas.
Adenocarcinoma
Manipulating expression of endogenous oncogenic proteins using an antisense oligonucleotide approach in prostate cancer cells.
Adenocarcinoma
Microfluidic Biopsy Trapping Device for the Real-Time Monitoring of Tumor Microenvironment.
Adenocarcinoma
Motility analysis of pancreatic adenocarcinoma cells reveals a role for the atypical zeta isoform of protein kinase C in cancer cell movement.
Adenocarcinoma
Overproduction of urokinase-type plasminogen activator is regulated by phospholipase D- and protein kinase C-dependent pathways in murine mammary adenocarcinoma cells.
Adenocarcinoma
Pak-1 expression increases with progression of colorectal carcinomas to metastasis.
Adenocarcinoma
Phosphorylated Protein Kinase C (Zeta/Lambda) Expression in Colorectal Adenocarcinoma and Its Correlation with Clinicopathologic Characteristics and Prognosis.
Adenocarcinoma
Photoinduced inactivation of protein kinase C by dequalinium identifies the RACK-1-binding domain as a recognition site.
Adenocarcinoma
PKC? regulates the expression of PDL1 through multiple pathways to modulate immune suppression of pancreatic cancer cells.
Adenocarcinoma
PKCeta confers protection against apoptosis by inhibiting the pro-apoptotic JNK activity in MCF-7 cells.
Adenocarcinoma
PKCmu prevents CD95-mediated apoptosis and enhances proliferation in pancreatic tumour cells.
Adenocarcinoma
Possible involvement of Ca2+ mobilization and protein kinase C activation in the induction of spontaneous metastasis by mouse mammary adenocarcinoma cells.
Adenocarcinoma
Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis.
Adenocarcinoma
Protein kinase C and adenylate cyclase as targets for growth inhibition of human gastric cancer cells.
Adenocarcinoma
Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer.
Adenocarcinoma
Protein kinase C-delta regulates the stability of hypoxia-inducible factor-1 alpha under hypoxia.
Adenocarcinoma
Protein Kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer.
Adenocarcinoma
Regulation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in MCF-7 cells: comparison with regulatory mechanisms of pS2 expression.
Adenocarcinoma
Regulation of Na+/K+/Cl- cotransport and [3H]bumetanide binding site density by phorbol esters in HT29 cells.
Adenocarcinoma
Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells.
Adenocarcinoma
Resveratrol-induced inactivation of human gastric adenocarcinoma cells through a protein kinase C-mediated mechanism.
Adenocarcinoma
Sodium butyrate-mediated differentiation of colorectal cancer cells: regulation of PKCbetaII by PI 3-kinase.
Adenocarcinoma
Tamoxifen alters the localization of F-actin and alpha 5/beta 1-integrin fibronectin receptors in human endometrial stromal cells and carcinoma cells.
Adenocarcinoma
The 28-kDa protein whose phosphorylation is induced by protein kinase C activators in MCF-7 cells belongs to the family of low molecular mass heat shock proteins and is the estrogen-regulated 24-kDa protein.
Adenocarcinoma
TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: selective role of PKC-alpha and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides treatment.
Adenocarcinoma
Transcription factor Sp1 is upregulated by PKC? to drive the expression of YAP1 during pancreatic carcinogenesis.
Adenocarcinoma
Transcriptional regulation of surfactant proteins SP-A and SP-B by phorbol ester.
Adenocarcinoma
Tumor-promoting phorbol ester down-regulates the androgen induction of prostate-specific antigen in a human prostatic adenocarcinoma cell line.
Adenocarcinoma
[Regulation by protein kinase C of TGF-beta 1 expression in cultured cells of breast adenocarcinoma]
Adenocarcinoma of Lung
Activation of phospholipase D by bradykinin and sphingosine 1-phosphate in A549 human lung adenocarcinoma cells via different GTP-binding proteins and protein kinase C delta signaling pathways.
Adenocarcinoma of Lung
Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer.
Adenocarcinoma of Lung
Clinical significance of atypical protein kinase C (PKC? and PKC?) and its relationship with yes-associated protein in lung adenocarcinoma.
Adenocarcinoma of Lung
Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation.
Adenocarcinoma of Lung
Effect of staurosporine on the mobility and invasiveness of lung adenocarcinoma A549 cells: an in vitro study.
Adenocarcinoma of Lung
Localization of aPKC lambda/iota and its interacting protein, Lgl2, is significantly associated with lung adenocarcinoma progression.
Adenocarcinoma of Lung
Low expression of PRKCDBP promoted cisplatin resistance in lung adenocarcinoma by DNMT1 and TNF??.
Adenocarcinoma of Lung
Meta-analysis of oncogenic protein kinase Ciota signaling in lung adenocarcinoma.
Adenocarcinoma of Lung
P2u purinoceptor modulation of intracellular Ca2+ in a human lung adenocarcinoma cell line: down-regulation of Ca2+ influx by protein kinase C.
Adenocarcinoma of Lung
Phorbol ester-induced G1 phase arrest selectively mediated by protein kinase Cdelta-dependent induction of p21.
Adenocarcinoma of Lung
Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by cis-diamminedichloroplatinum(II).
Adenocarcinoma of Lung
PKC?, MMP?2 and MMP?9 expression in lung adenocarcinoma and association with a metastatic phenotype.
Adenocarcinoma of Lung
Protein kinase Calpha-responsive polymeric carrier: its application for gene delivery into human cancers.
Adenocarcinoma, Follicular
Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis.
Adenoma
ACTH and phorbol ester stimulated redistribution of protein kinase C in human cortisol-producing adrenal adenoma.
Adenoma
ACTH-induced cortisol secretion is mediated by cAMP and PKC in various adrenocortical adenomas.
Adenoma
Adrenomedullin gene expression and its different regulation in human adrenocortical and medullary tumors.
Adenoma
Altered protein kinase C activity in biopsies of human colonic adenomas and carcinomas.
Adenoma
Anti-proliferative activity of protein kinase C in apical compartments of human colonic crypts: evidence for a less activated protein kinase C in small adenomas.
Adenoma
Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells.
Adenoma
Correlation between protein kinase C activity and histopathological criteria in human colorectal adenoma.
Adenoma
Effects of a flaxseed mixture and plant oils rich in alpha-linolenic acid on the adenoma formation in multiple intestinal neoplasia (Min) mice.
Adenoma
Effects of the putatively oncogenic protein kinase Calpha D294G mutation on enzymatic activity and cell growth and its occurrence in human thyroid neoplasias.
Adenoma
Expression of multiple isoforms of protein kinase C in normal human colon mucosa and colon tumors and decreased levels of protein kinase C beta and eta mRNAs in the tumors.
Adenoma
Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status.
Adenoma
Expression profile analysis of two antisense lncRNAs to improve prognosis prediction of colorectal adenocarcinoma.
Adenoma
Hybridization studies of cultured human pituitary prl and gh producing adenoma cells: Effects of thyrotropin-releasing hormone, somatostatin, and phorbol ester.
Adenoma
Immunohistochemical evidence for the overexpression of protein kinase C in proliferative diseases of human thyroid.
Adenoma
Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.
Adenoma
Markers of function and proliferation in non-invasive and invasive bi- and plurihormonal adenomas of patients with acromegaly: an immunohistochemical study.
Adenoma
Methylation status of CpG islands in the promoter region of genes differentially expressed in colonic mucosa from adenoma patients and controls in response to altered vegetable intake.
Adenoma
Modulation of the Ca2+-sensing function of parathyroid cells in vitro and in hyperparathyroidism.
Adenoma
Pak-1 expression increases with progression of colorectal carcinomas to metastasis.
Adenoma
Protein kinase C activity and expression in normal and adenomatous human pituitaries.
Adenoma
Protein kinase C isoforms in the chemopreventive effects of a novel vitamin D3 analogue in rat colonic tumorigenesis.
Adenoma
Protein kinase C stimulates adenylate cyclase activity in prolactin-secreting rat adenoma (GH4C1) pituicytes by inactivating the inhibitory GTP-binding protein Gi.
Adenoma
Protein kinase C tissue localization in human colonic tumors suggests a role for adenoma growth control.
Adenoma
Protein Kinase-zeta inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells.
Adenoma, Liver Cell
Alteration of protein kinase C isoform-specific expression during rat hepatocarcinogenesis after exposure to the peroxisome proliferator WY-14,643.
Adenomatous Polyposis Coli
Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis.
Adenoviridae Infections
Induction of the SHARP-2 mRNA level by insulin is mediated by multiple signaling pathways.
Adrenocortical Carcinoma
AngII induces transient phospholipase D activity in the H295R glomerulosa cell model.
Adrenocortical Carcinoma
Differential control of 17 alpha-hydroxylase and 3 beta-hydroxysteroid dehydrogenase expression in human adrenocortical H295R cells.
Adrenocortical Carcinoma
Expression and regulation of the lipoprotein lipase gene in human adrenal cortex.
Adrenocortical Carcinoma
Negative regulation of atrial natriuretic factor receptor coupled membrane guanylate cyclase by phorbol ester. Potential protein kinase C regulation of cyclic GMP signal in isolated adrenocortical carcinoma cells of rat.
Adrenocortical Carcinoma
Protein kinase C-induced activin A switches adrenocortical steroidogenesis to aldosterone by suppressing CYP17A1 expression.
Adrenocortical Carcinoma
Regulation of 3 beta-hydroxysteroid dehydrogenase expression in human adrenocortical H295R cells.
Adrenoleukodystrophy
Perturbation of protein kinase C subtype activation in X-ALD fibroblasts: possible involvement of protein kinase C in the pathogenesis of adrenoleukodystrophy.
Adrenoleukodystrophy
Phospholipase D activity is altered in X-linked adrenoleukodystrophy heterozygous carriers, but not in hemizygous patients.
Aggressive Periodontitis
Altered diacylglycerol level and metabolism in neutrophils from patients with localized juvenile periodontitis.
Aggressive Periodontitis
Chemoluminescence generation and MTT dye reduction by polymorphonuclear leukocytes from periodontal disease patients.
Aggressive Periodontitis
Defective calcium influx factor activity in neutrophils from patients with localized juvenile periodontitis.
Albuminuria
Additive effects of hypertension and diabetes on renal cortical expression of PKC-alpha and -epsilon and alpha-tubulin but not PKC-beta 1 and -beta 2.
Albuminuria
Bioactive peptides control receptor for advanced glycated end product-induced elevation of kidney insulin receptor substrate 2 and reduce albuminuria in diabetic mice.
Albuminuria
Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-alpha-deficient diabetic mice.
Albuminuria
Effect of protein kinase C modulators on the leucocyte Na+/H+ antiport in type 1 (insulin-dependent) diabetic subjects with albuminuria.
Albuminuria
Kidney outcomes in long-term studies of ruboxistaurin for diabetic eye disease.
Albuminuria
Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo.
Albuminuria
Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C.
Albuminuria
Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol.
Albuminuria
Renoprotective effect of a novel selective PPAR? modulator K-877 in db/db mice: A role of diacylglycerol-protein kinase C-NAD(P)H oxidase pathway.
Alcoholic Neuropathy
Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat.
Alkalosis
Impaired protein kinase C activation is associated with decreased hepatic alpha 1-adrenoreceptor responsiveness in adrenalectomized rats.
Alkalosis
PKC activation is required by EGF-stimulated Na(+)-H+ exchanger in human pleural mesothelial cells.
Alopecia
Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.
Alzheimer Disease
A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein.
Alzheimer Disease
A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity.
Alzheimer Disease
Activation of protein kinase C increases the extracellular release of the transmembrane amyloid protein precursor of Alzheimer's disease.
Alzheimer Disease
Age does not alter Protein kinase C isozymes mRNA expression in rat brain.
Alzheimer Disease
Alteration of protein kinase C conformation in red blood cells: a potential marker for Alzheimer's disease but not for Parkinson's disease.
Alzheimer Disease
Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer's disease.
Alzheimer Disease
Attenuated protein kinase C activity and translocation in Alzheimer's disease brain.
Alzheimer Disease
Atypical protein kinase C in neurodegenerative disease I: PKMzeta aggregates with limbic neurofibrillary tangles and AMPA receptors in Alzheimer disease.
Alzheimer Disease
Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies.
Alzheimer Disease
Autoradiographic imaging of [3H]phorbol 12,13-dibutyrate binding to protein kinase C in Alzheimer's disease.
Alzheimer Disease
Benzolactam (BL) enhances sAPP secretion in fibroblasts and in PC12 cells.
Alzheimer Disease
Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway.
Alzheimer Disease
Biphasic modulation of protein kinase C and enhanced cell toxicity by amyloid beta peptide and anoxia in neuronal cultures.
Alzheimer Disease
Blockade of PKC epsilon activation attenuates phorbol ester-induced increase of alpha-secretase-derived secreted form of amyloid precursor protein.
Alzheimer Disease
Bryostatin Effects on Cognitive Function and PKC? in Alzheimer's Disease Phase IIa and Expanded Access Trials.
Alzheimer Disease
Bryostatin improves survival and reduces ischemic brain injury in aged rats after acute ischemic stroke.
Alzheimer Disease
Ca2+-dependent and Ca2+-independent protein kinase C changes in the brain of patients with Alzheimer's disease.
Alzheimer Disease
Calycosin improves cognitive function in a transgenic mouse model of Alzheimer's disease by activating the protein kinase C pathway.
Alzheimer Disease
Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase C?
Alzheimer Disease
Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase C?.
Alzheimer Disease
Characterization and differential distribution of the three major human protein kinase C isozymes (PKC alpha, PKC beta, and PKC gamma) of the central nervous system in normal and Alzheimer's disease brains.
Alzheimer Disease
Common mechanisms of Alzheimer's disease and ischemic stroke: the role of protein kinase C in the progression of age-related neurodegeneration.
Alzheimer Disease
Conventional protein kinase C (PKC)-alpha and novel PKC epsilon, but not -delta, increase the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts.
Alzheimer Disease
Cytosol protein kinase C downregulation in fibroblasts from Alzheimer's disease patients.
Alzheimer Disease
Defective protein kinase C alpha leads to impaired secretion of soluble beta-amyloid precursor protein from Alzheimer's disease fibroblasts.
Alzheimer Disease
Differential involvement of protein kinase C isozymes in Alzheimer's disease.
Alzheimer Disease
Disrupted muscarinic M1 receptor signaling correlates with loss of protein kinase C activity and glutamatergic deficit in Alzheimer's disease.
Alzheimer Disease
Diverse Biological Functions of Sphingolipids in the CNS: Ceramide and Sphingosine Regulate Myelination in Developing Brain but Stimulate Demyelination during Pathogenesis of Multiple Sclerosis.
Alzheimer Disease
Drug Development for Neurodegenerative Diseases--Second Annual marcus evans Conference. Advances in drug development for NDD and expediting discovery through novel compounds and sound clinical trials.
Alzheimer Disease
Effects of chronic lithium treatment on platelet PKC isozymes in Alzheimer's and elderly control subjects.
Alzheimer Disease
Emodin attenuates Alzheimer's disease by activating the protein kinase C signaling pathway.
Alzheimer Disease
Genetic Analysis of PICK1 Gene in Alzheimer's Disease: A Study for Finding a New Gene Target.
Alzheimer Disease
Genistein Inhibits A?(25-35) -Induced Neurotoxicity in PC12 Cells via PKC Signaling Pathway.
Alzheimer Disease
Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ?-mediated metalloproteinase 2 and 9 levels in ?-amyloid infused Alzheimer's disease rat model.
Alzheimer Disease
Increased natural killer cell cytotoxicity in Alzheimer's disease may involve protein kinase C dysregulation.
Alzheimer Disease
Lack of overt genome reduction in the bryostatin-producing bryozoan symbiont, "Candidatus Endobugula sertula".
Alzheimer Disease
Loss in PKC Epsilon Causes Downregulation of MnSOD and BDNF Expression in Neurons of Alzheimer's Disease Hippocampus.
Alzheimer Disease
Metabotropic glutamate receptors increase amyloid precursor protein processing in astrocytes: inhibition by cyclic AMP.
Alzheimer Disease
Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes.
Alzheimer Disease
Molecular identification of protein kinase C beta in Alzheimer's disease.
Alzheimer Disease
NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube.
Alzheimer Disease
Peptide-based ligand screening and functional analysis of protein kinase C.
Alzheimer Disease
Phosphoinositide hydrolysis, G alpha q, phospholipase C, and protein kinase C in post mortem human brain: effects of post mortem interval, subject age, and Alzheimer's disease.
Alzheimer Disease
Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II.
Alzheimer Disease
PKC activators enhance GABAergic neurotransmission and paired-pulse facilitation in hippocampal CA1 pyramidal neurons.
Alzheimer Disease
Protein kinase C -activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations.
Alzheimer Disease
Protein kinase C alteration is an early biochemical marker in Alzheimer's disease.
Alzheimer Disease
Protein kinase C anchoring deficit in postmortem brains of Alzheimer's disease patients.
Alzheimer Disease
Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer's disease cases.
Alzheimer Disease
Protein kinase C eta is activated in reactive astrocytes of an Alzheimer's disease mouse model: Evidence for its immunoregulatory function in primary astrocytes.
Alzheimer Disease
Protein kinase C iota protects neural cells against apoptosis induced by amyloid beta-peptide.
Alzheimer Disease
Protein kinase C-epsilon (PKC-epsilon): its unique structure and function.
Alzheimer Disease
Protein kinase C-zeta activity but not level is decreased in Alzheimer's disease microvessels.
Alzheimer Disease
Protein kinases A and C regulate amyloid-? degradation by modulating protein levels of neprilysin and insulin-degrading enzyme in astrocytes.
Alzheimer Disease
Rab6 membrane association is dependent of Presenilin 1 and cellular phosphorylation events.
Alzheimer Disease
Reduced membrane-associated protein kinase C(beta) immunoreactivity in the hippocampus of reserpinized rat brain.
Alzheimer Disease
Reduced protein kinase C activity in sporadic Alzheimer's disease fibroblasts.
Alzheimer Disease
Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts.
Alzheimer Disease
Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C alpha.
Alzheimer Disease
Restoration of TEA-induced calcium responses in fibroblasts from Alzheimer's disease patients by a PKC activator.
Alzheimer Disease
Scallop-derived plasmalogens attenuate the activation of PKC? associated with the brain inflammation.
Alzheimer Disease
Sodium Phenylbutyrate Enhances Astrocytic Neurotrophin Synthesis via Protein Kinase C (PKC)-mediated Activation of cAMP-response Element-binding Protein (CREB): IMPLICATIONS FOR ALZHEIMER DISEASE THERAPY.
Alzheimer Disease
Specific role for protein kinase C alpha in the constitutive and regulated secretion of amyloid precursor protein in human skin fibroblasts.
Alzheimer Disease
Structural insights into the interactions of phorbol ester and bryostatin complexed with protein kinase C: a comparative molecular dynamics simulation study.
Alzheimer Disease
Synthesis and Biological Activities of Simplified Analogs of the Natural PKC Ligands, Bryostatin-1 and Aplysiatoxin.
Alzheimer Disease
Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-Lactones as Protein Kinase C Ligands.
Alzheimer Disease
Synthesis and Pharmacological Evaluation of 8- and 9-Substituted Benzolactam-V8 Derivatives as Potent Ligands for Protein Kinase C, a Therapeutic Target for Alzheimer's Disease.
Alzheimer Disease
Toward a Biorelevant Structure of Protein Kinase C Bound Modulators: Design, Synthesis, and Evaluation of Labeled Bryostatin Analogues for Analysis with Rotational Echo Double Resonance NMR Spectroscopy.
Alzheimer Disease
[Reduced neuronal nitric oxide synthetase and c-protein kinase levels in Alzheimer's disease]
Alzheimer Disease
[Resveratrol upregulates the gene and protein expressions of N-methyl-D-aspartate receptor 1 and protein kinase C in the hippocampus in Alzheimer's disease rats].
Amebiasis
Phorbol esters specifically enhance the cytolytic activity of Entamoeba histolytica.
Amnesia
Involvement of hippocampal PKCbetaI isoform in the early phase of memory formation of an inhibitory avoidance learning.
Amnesia
Post-training intrahippocampal infusion of protein kinase C inhibitors causes amnesia in rats.
Amnesia
Scopolamine Induced Amnesia is Reversed by Bacopa monniera Through Participation of Kinase-CREB Pathway.
Amyloidosis
Reversal of the Swedish familial Alzheimer's disease mutant phenotype in cultured cells treated with phorbol 12,13-dibutyrate.
Amyotrophic Lateral Sclerosis
A role for amplified protein kinase C activity in the pathogenesis of amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Aberrant deltaPKC activation in the spinal cord of Wobbler mouse: a model of motor neuron disease.
Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis: the involvement of intracellular Ca2+ and protein kinase C.
Amyotrophic Lateral Sclerosis
Decrease of protein kinase C in the spinal motor neurons of amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Increased phospho-adducin immunoreactivity in a murine model of amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases.
Amyotrophic Lateral Sclerosis
Protein interacting with C kinase and neurological disorders.
Amyotrophic Lateral Sclerosis
Protein Interacting with C-Kinase 1 Deficiency Impairs Glutathione Synthesis and Increases Oxidative Stress via Reduction of Surface Excitatory Amino Acid Carrier 1.
Amyotrophic Lateral Sclerosis
[3H]phorbol 12,13-dibutyrate/PKC binding in thoracic spinal cord: no change in amyotrophic lateral sclerosis.
Anemia
Effects of PKC alpha activation on Ca2+ pump and K(Ca) channel in deoxygenated sickle cells.
Anemia
In vivo and in vitro iron deficiency reduces protein kinase C activity and translocation in murine splenic and purified T cells.
Anemia, Iron-Deficiency
In vivo and in vitro iron deficiency reduces protein kinase C activity and translocation in murine splenic and purified T cells.
Anemia, Sickle Cell
Sickle red blood cells stimulate endothelial cell production of eicosanoids and diacylglycerol.
Aniridia
Comparison of protein kinase C subtype expression between normal and aniridic human ocular surfaces: implications for limbal stem cell dysfunction in aniridia.
Anorectal Malformations
Upregulation of miR-92a-2-5p potentially contribute to anorectal malformations by inhibiting proliferation and enhancing apoptosis via PRKCA/?-catenin.
Anthrax
Activation of phospholipase C and protein kinase C is required for expression of anthrax lethal toxin cytotoxicity in J774A.1 cells.
Aortic Aneurysm
Differential protein kinase C isoform abundance in ascending aortic aneurysms from patients with bicuspid versus tricuspid aortic valves.
Aortic Coarctation
Vascular responsiveness to nitric oxide synthesis inhibition in hypertensive rats.
Aortic Valve Stenosis
Protein kinase C in the human heart: differential regulation of the isoforms in aortic stenosis or dilated cardiomyopathy.
Apnea
Adenosine A3 receptors potentiate hippocampal calcium current by a PKA-dependent/PKC-independent pathway.
Apnea
Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition.
Arrhythmias, Cardiac
Altered thyroid status affects myocardial expression of connexin-43 and susceptibility of rat heart to malignant arrhythmias that can be partially normalized by red palm oil intake.
Arrhythmias, Cardiac
Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide.
Arrhythmias, Cardiac
PKC?II specifically regulates KCNQ1/KCNE1 channel membrane localization.
Arrhythmias, Cardiac
Protective role of protein kinase C epsilon activation in ischemia-reperfusion arrhythmia.
Arrhythmias, Cardiac
Protein kinase C is involved in cardioprotective effects of ischemic preconditioning on infarct size and ventricular arrhythmia in rats in vivo.
Arrhythmias, Cardiac
[Activating protein kinase C enhances ventricular action potential duration restitution and increase arrhythmia susceptibility in Langendorff-perfused rabbit hearts].
Arthralgia
Sensitization of TRPV1 by protein kinase C in rats with mono-iodoacetate-induced joint pain.
Arthritis
Effects of a protein kinase C inhibitor (PKCI) on the development of adjuvant-induced arthritis (AA) in rats.
Arthritis
Elevated serum nitric oxide levels in patients with inflammatory arthritis associated with co-expression of inducible nitric oxide synthase and protein kinase C-eta in peripheral blood monocyte-derived macrophages.
Arthritis
In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists.
Arthritis
Regulation of 1 alpha, 25-dihydroxyvitamin D3 synthesis in macrophages from arthritic joints by phorbol ester, dibutyryl-cAMP and calcium ionophore (A23187).
Arthritis
Small molecule inhibitors of PKCTheta as potential antiinflammatory therapeutics.
Arthritis
The natural stilbenoid pinosylvin and activated neutrophils: effects on oxidative burst, protein kinase C, apoptosis and efficiency in adjuvant arthritis.
Arthritis, Experimental
The natural stilbenoid pinosylvin and activated neutrophils: effects on oxidative burst, protein kinase C, apoptosis and efficiency in adjuvant arthritis.
Arthritis, Rheumatoid
An Update on Calcineurin Inhibitor-Free Regimens: The Need Persists, but the Landscape has Changed.
Arthritis, Rheumatoid
Antiproliferative naphthopyrans: biological activity, mechanistic studies and therapeutic potential.
Arthritis, Rheumatoid
Association and expression study of PRKCH gene in a French Caucasian population with rheumatoid arthritis.
Arthritis, Rheumatoid
Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells.
Arthritis, Rheumatoid
Discovery of 2,4-diamino-5-cyanopyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions.
Arthritis, Rheumatoid
Divergent effects of infliximab and anakinra therapies on macrophage phenotype from patients with refractory rheumatoid arthritis.
Arthritis, Rheumatoid
Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liability.
Arthritis, Rheumatoid
Quantitative immunodetection of key elements of polyphosphoinositide signal transduction in osteoblasts from arthritic patients shows a direct correlation with cell proliferation.
Asthma
An experimental study on the regulation of expression of Th2 cytokines from T lymphocytes by protein kinase C in asthma.
Asthma
Bronchial inflammation induced PKC(?) over-expression: involvement in mechanical properties of airway smooth muscle.
Asthma
Effects of mitochondrial ATP-sensitive K(+) channel on protein kinase C pathway and airway smooth muscle cell proliferation in asthma.
Asthma
Expression and function of the beta-adrenergic receptor coupled-adenylyl cyclase system on human airway epithelial cells.
Asthma
Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.
Asthma
Increased levels of protein kinase C in lymphocytes in asthma: possible mechanism of regulation.
Asthma
Inhibition of airway smooth muscle tone by a phorbol ester in the guinea pig trachea: role of epithelium and receptor reserve of the contractile agent.
Asthma
Regulation of the beta-receptor-adenylate cyclase system in lymphocytes of allergic patients with asthma: possible role for protein kinase C in allergen-induced nonspecific refractoriness of adenylate cyclase.
Asthma
Role of protein kinase C alpha and cyclin D1 in the proliferation of airway smooth muscle in asthmatic rats.
Asthma
The effect of smooth muscle relaxants working through different transduction mechanisms on the phorbol dibutyrate-induced contraction of the guinea-pig lung parenchymal strip: possible relevance for asthma.
Asthma
Therapeutic target validation of protein kinase C(PKC)-zeta for asthma using a mouse model.
Asthma
Up-regulation of cyclin D1 expression in asthma serum-sensitized human airway smooth muscle promotes proliferation via protein kinase C alpha.
Asthma
[An experimental study on the regulation of the expression of Th2 cytokines by nuclear factor-kappaB and protein kinase C in asthma]
Asthma
[The effect of inhaled glucocorticosteroid on protein kinase Calpha expression and interleukin-5 production in induced sputum inflammatory cells of asthma patients]
Astrocytoma
A high throughput system for the evaluation of protein kinase C inhibitors based on Elk1 transcriptional activation in human astrocytoma cells.
Astrocytoma
A novel approach for examining the anti-proliferative effect of protein kinase C inhibitors against human astrocytoma cells.
Astrocytoma
Activation of protein kinase C inhibits internalization and downregulation of muscarinic receptors in 1321N1 human astrocytoma cells.
Astrocytoma
Agonists and phorbol esters desensitize beta-adrenergic receptors by different mechanisms.
Astrocytoma
Astrocytes regulate GFAP mRNA levels by cyclic AMP and protein kinase C-dependent mechanisms.
Astrocytoma
cAMP-dependent down-regulation of endothelin-1 receptors on rat astrocytoma C6 cells.
Astrocytoma
Differential in vitro neurotoxicity of the flame retardant PBDE-99 and of the PCB Aroclor 1254 in human astrocytoma cells.
Astrocytoma
Dual effects of histamine and substance P on intracellular calcium levels in human U373 MG astrocytoma cells: role of protein kinase C.
Astrocytoma
Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas.
Astrocytoma
Expression pattern of alpha-protein kinase C in human astrocytomas indicates a role in malignant progression.
Astrocytoma
Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility.
Astrocytoma
HIV-1 Nef alters the expression of betaII and epsilon isoforms of protein kinase C and the activation of the long terminal repeat promoter in human astrocytoma cells.
Astrocytoma
Immunohistochemical demonstration of protein kinase C isozymes in human brain tumors.
Astrocytoma
Increases in intracellular Ca2+ regulate the binding of [3H]phorbol 12,13-dibutyrate to intact 1321N1 astrocytoma cells.
Astrocytoma
Inhibition of muscarinic receptor-induced proliferation of astroglial cells by ethanol: mechanisms and implications for the fetal alcohol syndrome.
Astrocytoma
Inorganic lead activates the mitogen-activated protein kinase kinase-mitogen-activated protein kinase-p90(RSK) signaling pathway in human astrocytoma cells via a protein kinase C-dependent mechanism.
Astrocytoma
Inorganic lead stimulates DNA synthesis in human astrocytoma cells: role of protein kinase Calpha.
Astrocytoma
Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB.
Astrocytoma
Involvement of phosphatidylcholine-specific phospholipase C in thromboxane A2-induced activation of mitogen-activated protein kinase in astrocytoma cells.
Astrocytoma
Lithium chloride at a therapeutic concentration reduces Ca2+ response in protein kinase C down-regulated human astrocytoma cells.
Astrocytoma
Neurotrophic factor production in human astrocytoma cells by 2,5,6-tribromogramine via activation of epsilon isoform of protein kinase C.
Astrocytoma
Nrf2-mediated adaptive response to cadmium-induced toxicity involves protein kinase C delta in human 1321N1 astrocytoma cells.
Astrocytoma
Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples.
Astrocytoma
Phorbol-12-myristate-13-acetate (PMA) and inhibitors of protein kinase C alter glial fibrillary acidic protein (GFAP) mRNA levels.
Astrocytoma
Phospholipase C, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells.
Astrocytoma
PKC, p42/44 MAPK and p38 MAPK regulate hepatocyte growth factor secretion from human astrocytoma cells.
Astrocytoma
PKC? and PKC? Activation Regulates Transcriptional Activity and Degradation of Progesterone Receptor in Human Astrocytoma Cells.
Astrocytoma
Possible role of protein kinase C zeta in muscarinic receptor-induced proliferation of astrocytoma cells.
Astrocytoma
Progesterone Receptor Together with PKC? Expression as Prognostic Factors for Astrocytomas Malignancy.
Astrocytoma
Protein kinase C activators sensitize cyclic AMP accumulation by intact 1321N1 human astrocytoma cells.
Astrocytoma
Protein kinase C mediates delayed inhibitory feedback regulation of human neurokinin type 1 receptor activation of phospholipase C in UC11 astrocytoma cells.
Astrocytoma
Protein kinase C modulation of phosphoinositidase C in 1321N1 human astrocytoma cells.
Astrocytoma
Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells.
Astrocytoma
Regulated expression of a dominant negative protein kinase C epsilon mutant inhibits the proliferation of U-373MG human astrocytoma cells.
Astrocytoma
Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells.
Astrocytoma
Serotonin via 5-HT7 receptors activates p38 mitogen-activated protein kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells.
Astrocytoma
Signal transduction mechanisms involved in the antiproliferative effects of ethanol in glial cells.
Astrocytoma
Sodium valproate at therapeutic concentrations changes Ca2+ response accompanied with its weak inhibition of protein kinase C in human astrocytoma cells.
Astrocytoma
Substance P and histamine induce interleukin-6 expression in human astrocytoma cells by a mechanism involving protein kinase C and nuclear factor-IL-6.
Astrocytoma
The role of protein kinase C alpha and epsilon isozymes in DNA synthesis induced by muscarinic receptors in a glial cell line.
Astrocytoma
Tyrosine kinase activity is essential for interleukin-1 beta--stimulated production of interleukin-6 in U373 human astrocytoma cells.
Astrocytoma
[The stimulation of glutamate uptake by the phorbol ester in rat cerebral cortex synaptosomes and cell line of human anaplastic astrocytoma BT-325]
Ataxia
Caffeine inhibits UV-mediated NF-kappaB activation in A2058 melanoma cells: an ATM-PKCdelta-p38 MAPK-dependent mechanism.
Ataxia
Cerebellar neurochemical alterations in spinocerebellar ataxia type 14 appear to include glutathione deficiency.
Ataxia
Circumvention of nuclear factor kappaB-induced chemoresistance by cytoplasmic-targeted anthracyclines.
Ataxia
Clinical and Neurophysiological Profile of Four German Families with Spinocerebellar Ataxia Type 14.
Ataxia
Inositol 1,4,5-trisphosphate receptors and protein kinase C in olivopontocerebellar atrophy.
Ataxia
Metabotropic glutamate receptor 5 modulates behavioral and hypothermic responses to toluene in rats.
Ataxia
Pharmacological and phosphoproteomic approaches to roles of protein kinase C in kappa opioid receptor-mediated effects in mice.
Ataxia
Protein kinase C gamma, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin.
Ataxia
Role of protein kinase C family in the cerebellum-dependent adaptive learning of horizontal optokinetic response eye movements in mice.
Ataxia Telangiectasia
Characterization of the signal transduction pathway mediating gamma ray-induced inhibition of DNA synthesis in human cells: indirect evidence for involvement of calmodulin but not protein kinase C nor p53.
Ataxia Telangiectasia
Human SMG-1 is Involved in Gemcitabine-Induced Primary microRNA-155/BIC Up-Regulation in Human Pancreatic Cancer PANC-1 Cells.
Ataxia Telangiectasia
Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy.
Ataxia Telangiectasia
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.
Ataxia Telangiectasia
Novel mutations and defective protein kinase C activation of T-lymphocytes in ataxia telangiectasia.
Ataxia Telangiectasia
PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.
Ataxia Telangiectasia
PTEN expression in U251 glioma cells enhances their sensitivity to ionizing radiation by suppressing DNA repair capacity.
Ataxia Telangiectasia
The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.
Atherosclerosis
7-Ketocholesteryl-9-carboxynonanoate induced nuclear factor-kappa B activation in J774A.1 macrophages.
Atherosclerosis
Activation of protein kinase C and disruption of endothelial monolayer integrity by sodium arsenite--Potential mechanism in the development of atherosclerosis.
Atherosclerosis
Activation of protein kinase Czeta is essential for cytokine-induced metalloproteinase-1, -3, and -9 secretion from rabbit smooth muscle cells and inhibits proliferation.
Atherosclerosis
Acute hyperglycemia regulates transcription and posttranscriptional stability of PKCbetaII mRNA in vascular smooth muscle cells.
Atherosclerosis
ANG II stimulates phospholipase D through PKCzeta activation in VSMC: implications in adhesion, spreading, and hypertrophy.
Atherosclerosis
Biomechanical stress induces IL-6 expression in smooth muscle cells via Ras/Rac1-p38 MAPK-NF-kappaB signaling pathways.
Atherosclerosis
Carotid atherosclerotic plaques: proteomics study after a low-abundance protein enrichment step.
Atherosclerosis
Differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking the G-protein G?11.
Atherosclerosis
Edaravone, a radical scavenger, may enhance or produce antiproliferative effects of fluvastatin, amlodipine, ozagrel, GF109203X and Y27632 on cultured basilar artery smooth muscle cells.
Atherosclerosis
Effect of trifluoperazine on DNA and LDL-receptor synthesis in smooth muscle cells exposed to hypercholesterolemic medium in vitro.
Atherosclerosis
Essential role of protein kinase C ?I in icariin-mediated protection against atherosclerosis.
Atherosclerosis
Fluid-Phase Pinocytosis of LDL by Macrophages: A Novel Target to Reduce Macrophage Cholesterol Accumulation in Atherosclerotic Lesions.
Atherosclerosis
Mice deficient in PKCbeta and apolipoprotein E display decreased atherosclerosis.
Atherosclerosis
Molecular mechanisms of cholesterol or homocysteine effect in the development of atherosclerosis: Role of vitamin E.
Atherosclerosis
Molecular mechanisms of hydrogen sulfide against uremic accelerated atherosclerosis through cPKC?II/Akt signal pathway.
Atherosclerosis
Nucleoside reverse transcriptase inhibitors prevent HIV protease inhibitor-induced atherosclerosis by ubiquitination and degradation of protein kinase C.
Atherosclerosis
Pathogenic factors in vascular dementia and Alzheimer's disease. Multiple actions of heparin that probably are beneficial.
Atherosclerosis
Pathophysiology of atherosclerosis: Association of risk factors and treatment strategies using plant-based bioactive compounds.
Atherosclerosis
PKC? mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation.
Atherosclerosis
PKC? promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null mice.
Atherosclerosis
Potential Role of Protein Kinase C in the Pathophysiology of Diabetes-Associated Atherosclerosis.
Atherosclerosis
Protein kinase C beta/early growth response-1 pathway: a key player in ischemia, atherosclerosis, and restenosis.
Atherosclerosis
Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells.
Atherosclerosis
Transcription factor and kinase-mediated signaling in atherosclerosis and vascular injury.
Atherosclerosis
[Activity of membrane-bound protein kinase C and ATPase in erythrocytes in diabetic angiopathy]
Atrial Fibrillation
Binge Alcohol Exposure Triggers Atrial Fibrillation Through T-Type Ca2+ Channel Upregulation via Protein Kinase C (PKC) / Glycogen Synthesis Kinase 3? (GSK3?) / Nuclear Factor of Activated T-Cells (NFAT) Signaling?- An Experimental Account of Holiday Heart Syndrome.
Atrial Fibrillation
Protein kinase C activation inhibits alpha1D L-type Ca channel: a single-channel analysis.
Atrial Fibrillation
[Study on the total activity of PKC and the quantity of PKC (alpha, beta) in left auricle tissues of the patients with mitral disease and atrial fibrillation]
Autoimmune Diseases
A novel 2,4-diaminopyrimidine derivative as selective inhibitor of protein kinase C theta prevents allograft rejection in a rat heart transplant model.
Autoimmune Diseases
Avian scleroderma: evidence for qualitative and quantitative T cell defects.
Autoimmune Diseases
Design and Optimization of Selective Protein Kinase C ? (PKC?) Inhibitors for the Treatment of Autoimmune Diseases.
Autoimmune Diseases
Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation.
Autoimmune Diseases
Protein kinase C theta (PKCtheta): a key player in T cell life and death.
Autoimmune Diseases
Resistance to Experimental Autoimmune Encephalomyelitis and Impaired IL-17 Production in Protein Kinase C{theta}-Deficient Mice.
Azoospermia
The expression of microRNAs and exposure to environmental contaminants related to human health: a review.
Bacterial Infections
Localization of protein kinase C epsilon to macrophage vacuoles perforated by Listeria monocytogenes cytolysin.
Bacterial Infections
Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection.
Bacterial Infections
Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice.
Barrett Esophagus
Acid- and bile-induced PGE(2) release and hyperproliferation in Barrett's esophagus are COX-2 and PKC-epsilon dependent.
Barth Syndrome
Reduced protein kinase C delta association with a higher molecular weight complex in mitochondria of Barth Syndrome lymphoblasts.
Blast Crisis
Cross-talk between Bcr-Abl tyrosine kinase, protein kinase C and telomerase-a potential reason for resistance to Glivec in chronic myelogenous leukaemia.
Blister
Oxidative stress induces actin-cytoskeletal and tight-junctional alterations in hepatocytes by a Ca2+ -dependent, PKC-mediated mechanism: protective effect of PKA.
Blister
Pemphigus IgG activates and translocates protein kinase C from the cytosol to the particulate/cytoskeleton fractions in human keratinocytes.
Blister
Quantitative proteome analysis of detergent-resistant membranes identifies the differential regulation of protein kinase C isoforms in apoptotic T cells.
Blister
Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp.
Blister
Structure-activity relationship within a series of degradation products of tautomycin.
Blister
The Extent of Desmoglein 3 Depletion in Pemphigus Vulgaris Is Dependent on Ca(2+)-Induced Differentiation A Role in Suprabasal Epidermal Skin Splitting?
Blister
[The effect of endothelin and protein kinase C on the vasoactive mechanisms of beta A(4)25-35 at skin microvasculature]
Bone Diseases, Metabolic
Effects of dietary restriction on appendicular bone in the SENCAR mouse.
Bone Neoplasms
Involvement of the spinal NMDA receptor/PKCgamma signaling pathway in the development of bone cancer pain.
Bone Neoplasms
Vascular Endothelial Growth Factor A Signaling Promotes Spinal Central Sensitization and Pain-related Behaviors in Female Rats with Bone Cancer.
Bone Neoplasms
[Bone-edge electroacupuncture relieves pain by regulating expression of GRK5, ?-arrestin 2 and PKC? proteins in locus coeruleus in bone cancer pain rats with morphine tolerance].
Bone Resorption
12-O-tetradecanoylphorbol-13-acetate (TPA) Inhibits Osteoclastogenesis by Suppressing RANKL-Induced NF-?B Activation.
Bone Resorption
12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits osteoclastogenesis by suppressing RANKL-induced NF-kappaB activation.
Bone Resorption
12-O-tetradecanoylphorbol-13-acetate, a phorbol ester stimulating protein kinase C, inhibits bone resorption in vitro induced by parathyroid hormone and parathyroid hormone-related peptide of malignancy.
Bone Resorption
A novel protein kinase C alpha-dependent signal to ERK1/2 activated by alphaVbeta3 integrin in osteoclasts and in Chinese hamster ovary (CHO) cells.
Bone Resorption
Anabolic effects of insulin on bone suggest a role for chromium picolinate in preservation of bone density.
Bone Resorption
Bone resorption induced by A23187 is abolished by indomethacin: implications for second messenger utilised by parathyroid hormone.
Bone Resorption
Ca2+ or phorbol ester but not inflammatory stimuli elevate inducible nitric oxide synthase messenger ribonucleic acid and nitric oxide (NO) release in avian osteoclasts: autocrine NO mediates Ca2+-inhibited bone resorption.
Bone Resorption
Calcitonin causes a sustained inhibition of protein kinase c-stimulated bone resorption in contrast to the transient inhibition of parathyroid hormone-induced bone resorption.
Bone Resorption
Clear zone in osteoclast function: role of podosomes in regulation of bone-resorbing activity.
Bone Resorption
Differential effects of calmodulin and protein kinase C antagonists on bone resorption and acid transport activity.
Bone Resorption
Divergent effects of protein kinase C (PKC) inhibitors staurosporine and bisindolylmaleimide I (GF109203X) on bone resorption.
Bone Resorption
Effects of pertussis toxin on resorption of 19-day-old fetal rat long bones.
Bone Resorption
Evidence for the functional involvement of protein kinase C in the action of 1,25-dihydroxyvitamin D3 in bone.
Bone Resorption
Parathyroid hormone-induced calcium efflux from cultured bone is mediated by protein kinase C translocation.
Bone Resorption
Phorbol myristate acetate stimulates osteoclast formation in 1 alpha,25-dihydroxyvitamin D3-primed mouse embryonic calvarial cells by a prostaglandin-dependent mechanism.
Bone Resorption
Protein kinase C affects microfilaments, bone resorption, and [Ca2+]o sensing in cultured osteoclasts.
Bone Resorption
Protein Kinase C Inhibitor, GF109203X Attenuates Osteoclastogenesis, Bone Resorption and RANKL-Induced NF-?B and NFAT Activity.
Bone Resorption
Rho and Rho kinase are involved in parathyroid hormone-stimulated protein kinase C alpha translocation and IL-6 promoter activity in osteoblastic cells.
Bone Resorption
Role of protein kinase C (PKC) in bone resorption: effect of the specific PKC inhibitor 1-alkyl-2-methylglycerol.
Bone Resorption
Tamoxifen inhibits phorbol ester stimulated osteoclastic bone resorption: an effect mediated by calmodulin.
Borna Disease
Borna Disease Virus Blocks Potentiation of Presynaptic Activity through Inhibition of Protein Kinase C Signaling.
Borna Disease
Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity.
Bowen's Disease
The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas.
Bradycardia
Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway.
Bradycardia
The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: Implications for neural control of cardiac excitability.
Brain Diseases
Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C.
Brain Diseases
Identification of Protein Kinase C Isoforms Involved in Type 1 Diabetic Encephalopathy in Mice.
Brain Diseases
Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats.
Brain Diseases
The PICK1/TLR4 complex on microglia is involved in the regulation of LPS-induced sepsis-associated encephalopathy.
Brain Edema
Effect of dimethyl sulfoxide on blood-brain barrier integrity following middle cerebral artery occlusion in the rat.
Brain Edema
Inhibition by H-7 of the protein kinase C prevents formation of brain edema in Sprague-Dawley CFY rats.
Brain Edema
Modulation of AQP4 expression by the protein kinase C activator, phorbol myristate acetate, decreases ischemia-induced brain edema.
Brain Edema
The effects of protein kinase C activator phorbol dibutyrate on traumatic brain edema and aquaporin-4 expression.
Brain Edema
[Effects of inhibitor of protein kinase C on brain edema formation evoked by experimental cerebral ischemia in gerbils and rats]
Brain Infarction
[Molecular epidemiology of cerebrovascular diseases; the Hisayama study and the Fukuoka Stroke Registry (FSR)]
Brain Injuries
Anoxic injury of endothelial cells causes divergent changes in protein kinase C and protein kinase A signaling pathways.
Brain Injuries
Down-regulation of ASICs current and the calcium transients by disrupting PICK1 protects primary cultured mouse cortical neurons from OGD-Rep insults.
Brain Injuries
Perspectives on reperfusion-induced damage in rodent models of experimental focal ischemia and role of gamma-protein kinase C.
Brain Injuries
Protein kinase C activation generates superoxide and contributes to impairment of cerebrovasodilation induced by G protein activation after brain injury.
Brain Injuries
Protein Kinase C Inhibition Mediates Neuroblast Enrichment in Mechanical Brain Injuries.
Brain Injuries
Relationship between opioids and activation of phospholipase C and protein kinase C in brain injury induced pial artery vasoconstriction.
Brain Injuries
Roles of protein kinase C and inositol(1,4,5)-trisphosphate in the pathogenesis of hypoxic- ischemic brain injury in neonatal rats.
Brain Injuries
Superoxide generation links protein kinase C activation to impaired ATP-sensitive K+ channel function after brain injury.
Brain Injuries
The action of thrombin in intracerebral hemorrhage induced brain damage is mediated via PKC?/PKC? signaling.
Brain Injuries
The role of protein kinase C in ischemic tolerance induced by hyperoxia in rats with stroke.
Brain Injuries, Traumatic
Alterations of protein kinase C in rat hippocampus following traumatic brain injury.
Brain Injuries, Traumatic
Bryostatin improves survival and reduces ischemic brain injury in aged rats after acute ischemic stroke.
Brain Injuries, Traumatic
Endogenous phosphorylation of a 61,000 dalton hippocampal protein increases following traumatic brain injury.
Brain Injuries, Traumatic
NOC/oFQ activates PKC and generates superoxide to impair hypotensive cerebrovasodilation after hypoxia/ischemia.
Brain Injuries, Traumatic
peroxisome proliferator-activated receptor alpha activation-mediated regulation of endothelin-1 production via nitric oxide and protein kinase C signaling pathways in piglet cerebral microvascular endothelial cell culture.
Brain Injuries, Traumatic
PICK1-mediated GluR2 endocytosis contributes to cellular injury after neuronal trauma.
Brain Injuries, Traumatic
The binding affinities of proteins interacting with the PDZ domain of PICK1.
Brain Ischemia
Acidosis enhances translocation of protein kinase C but not Ca(2+)/calmodulin-dependent protein kinase II to cell membranes during complete cerebral ischemia.
Brain Ischemia
Activation of epsilon protein kinase C-mediated anti-apoptosis is involved in rapid tolerance induced by electroacupuncture pretreatment through cannabinoid receptor type 1.
Brain Ischemia
Activation of Protein Kinase C Delta following Cerebral Ischemia Leads to Release of Cytochrome C from the Mitochondria via Bad Pathway.
Brain Ischemia
Alteration of protein kinase C activity after transient focal cerebral ischemia in mice using in vitro [3H]phorbol-12,13-dibutyrate binding autoradiography.
Brain Ischemia
Altered protein kinase C activity in different subfields of hippocampus following cerebral ischemia.
Brain Ischemia
An early loss in membrane protein kinase C activity precedes the excitatory amino acid-induced death of primary cortical neurons.
Brain Ischemia
Association of protein kinase C delta and phospholipid scramblase 3 in hippocampal mitochondria correlates with neuronal vulnerability to brain ischemia.
Brain Ischemia
Autoradiographic analysis on second-messenger systems and local cerebral blood flow in ischemic gerbil brain.
Brain Ischemia
Changes in the activity of protein kinase C and the differential subcellular redistribution of its isozymes in the rat striatum during and following transient forebrain ischemia.
Brain Ischemia
Decreased protein kinase C activity during cerebral ischemia and after reperfusion in the adult rat.
Brain Ischemia
Down-regulation of ASICs current and the calcium transients by disrupting PICK1 protects primary cultured mouse cortical neurons from OGD-Rep insults.
Brain Ischemia
Effect of staurosporine, a protein kinase C inhibitor, on impairment of working memory in rats exposed to cerebral ischemia.
Brain Ischemia
Enhanced maximal binding capacity (Bmax) of second messenger ligand in the acute phase of cerebral ischemia--direct visualization by digital image analysis.
Brain Ischemia
Epsilon PKC may contribute to the protective effect of hypothermia in a rat focal cerebral ischemia model.
Brain Ischemia
epsilonPKC phosphorylates the mitochondrial K(+) (ATP) channel during induction of ischemic preconditioning in the rat hippocampus.
Brain Ischemia
Evidence that brain-derived neurotrophic factor neuroprotection is linked to its ability to reverse the NMDA-induced inactivation of protein kinase C in cortical neurons.
Brain Ischemia
Evidence that the early loss of membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons.
Brain Ischemia
Expression of protein kinase C in postischemic brain: an in situ hybridization study.
Brain Ischemia
Geranylgeranylacetone, a noninvasive heat shock protein inducer, induces protein kinase C and leads to neuroprotection against cerebral infarction in rats.
Brain Ischemia
Green tea polyphenols alleviate early BBB damage during experimental focal cerebral ischemia through regulating tight junctions and PKCalpha signaling.
Brain Ischemia
Hypothermia prevents the ischemia-induced translocation and inhibition of protein kinase C in the rat striatum.
Brain Ischemia
Induction of protein kinase Cdelta subspecies in neurons and microglia after transient global brain ischemia.
Brain Ischemia
Involvement of gamma protein kinase C in estrogen-induced neuroprotection against focal brain ischemia through G protein-coupled estrogen receptor.
Brain Ischemia
Isoflurane inhibits protein kinase Cgamma and calcium/calmodulin dependent protein kinase ii-alpha translocation to synaptic membranes in ischemic mice brains.
Brain Ischemia
Isoform-specific membrane translocation of protein kinase C after ischemic preconditioning.
Brain Ischemia
Isoform-specific translocation of protein kinase C following glutamate administration in primary hippocampal neurons.
Brain Ischemia
Isoforms of protein kinase C in postsynaptic densities after cerebral ischemia.
Brain Ischemia
Limb Remote Postconditioning Alleviates Cerebral Reperfusion Injury Through Reactive Oxygen Species-Mediated Inhibition of Delta Protein Kinase C in Rats.
Brain Ischemia
Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia.
Brain Ischemia
Modulation of ischemic signal by antagonists of N-methyl-D-aspartate, nitric oxide synthase, and platelet-activating factor in gerbil hippocampus.
Brain Ischemia
Postreceptor modulation of cAMP accumulation in rat brain particulate fraction after ischemia--involvement of protein kinase C.
Brain Ischemia
Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta.
Brain Ischemia
Protection mechanism of early hyperbaric oxygen therapy in rats with permanent cerebral ischemia.
Brain Ischemia
Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation.
Brain Ischemia
Protein Kinase C Epsilon Promotes Cerebral Ischemic Tolerance Via Modulation of Mitochondrial Sirt5.
Brain Ischemia
Protein kinase C expression and activity after global incomplete cerebral ischemia in dogs.
Brain Ischemia
Protein kinase C inhibition attenuates vascular ETB receptor upregulation and decreases brain damage after cerebral ischemia in rat.
Brain Ischemia
Recombinant Human Angiopoietin-1 Ameliorates the Expressions of ZO-1, Occludin, VE-cadherin, and PKC? Signaling after Focal Cerebral Ischemia/Reperfusion in Rats.
Brain Ischemia
Role of reactive oxygen species and protein kinase C in ischemic tolerance in the brain.
Brain Ischemia
Specific induction of protein kinase C delta subspecies after transient middle cerebral artery occlusion in the rat brain: inhibition by MK-801.
Brain Ischemia
Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood-Brain Barrier in a Focal Cerebral Ischemic Insult.
Brain Ischemia
Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage.
Brain Ischemia
Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia.
Brain Ischemia
Time course of the translocation and inhibition of protein kinase C during complete cerebral ischemia in the rat.
Brain Ischemia
Vasopressin mediates neuroprotection in mice by stimulation of V1 vasopressin receptors: influence of PI-3 kinase and gap junction inhibitors.
Brain Ischemia
[Effect of electroacupuncture on cerebral PKC isozyme expression levels in cerebral ischemia-reperfusion rats].
Brain Ischemia
[Effects of inhibitor of protein kinase C on brain edema formation evoked by experimental cerebral ischemia in gerbils and rats]
Brain Neoplasms
Antisense expression of protein kinase C alpha inhibits the growth and tumorigenicity of human glioblastoma cells.
Brain Neoplasms
Genetic mechanisms regulating stem cell self-renewal and differentiation in the central nervous system of Drosophila.
Brain Neoplasms
Growth inhibition induced by Ro 31-8220 and calphostin C in human glioblastoma cell lines is associated with apoptosis and inhibition of CDC2 kinase.
Brain Neoplasms
Immunohistochemical demonstration of protein kinase C isozymes in human brain tumors.
Brain Neoplasms
Immunohistochemical determination of protein kinase C expression and proliferative activity in human brain tumors.
Brain Neoplasms
Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Calpha antisense oligonucleotide.
Brain Neoplasms
Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples.
Brain Neoplasms
PKC? and PKC? Activation Regulates Transcriptional Activity and Degradation of Progesterone Receptor in Human Astrocytoma Cells.
Brain Neoplasms
Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells.
Brain Neoplasms
Regulated expression of a dominant negative protein kinase C epsilon mutant inhibits the proliferation of U-373MG human astrocytoma cells.
Brain Neoplasms
Tamoxifen modulation of etoposide cytotoxicity involves inhibition of protein kinase C activity and insulin-like growth factor II expression in brain tumor cells.
Brain Neoplasms
Water permeability through aquaporin-4 is regulated by protein kinase C and becomes rate-limiting for glioma invasion.
Breast Neoplasms
A phase II study of oral enzastaurin in patients with metastatic breast cancer previously treated with an anthracycline and a taxane containing regimen.
Breast Neoplasms
A role for protein kinase C delta in the differential sensitivity of MCF-7 and MDA-MB 231 human breast cancer cells to phorbol ester-induced growth arrest and p21(WAFI/CIP1) induction.
Breast Neoplasms
A shift from normal to high glucose levels stimulates cell proliferation in drug sensitive MCF-7 human breast cancer cells but not in multidrug resistant MCF-7/ADR cells which overproduce PKC-betaII.
Breast Neoplasms
Activation by phorbol esters of protein kinase C in MCF-7 human breast cancer cells.
Breast Neoplasms
Activation by Tyrosine Phosphorylation as a Prerequisite for Protein Kinase C{zeta} to Mediate Epidermal Growth Factor Receptor Signaling to ERK.
Breast Neoplasms
Activation of protein kinase C by phorbol esters modulates alpha2beta1 integrin on MCF-7 breast cancer cells.
Breast Neoplasms
Activation of the integrin effector kinase focal adhesion kinase in cancer cells is regulated by crosstalk between protein kinase Calpha and the PDZ adapter protein mda-9/Syntenin.
Breast Neoplasms
Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones.
Breast Neoplasms
Adherence to osteopontin via alphavbeta3 suppresses phorbol ester-mediated apoptosis in MCF-7 breast cancer cells that overexpress protein kinase C-alpha.
Breast Neoplasms
Alkyl Cinnamates Induce Protein Kinase C Translocation and Anticancer Activity against Breast Cancer Cells through Induction of the Mitochondrial Pathway of Apoptosis.
Breast Neoplasms
All-trans retinoic acid and protein kinase C ?/?1 inhibitor combined treatment targets cancer stem cells and impairs breast tumor progression.
Breast Neoplasms
Alterations in skeletal protein, distribution of PKCalpha, and level of phospholipids in erythrocyte membranes of women with primary breast cancer.
Breast Neoplasms
An N-myristoylated protein kinase C-alpha pseudosubstrate peptide that functions as a multidrug resistance reversal agent in human breast cancer cells is not a P-glycoprotein substrate.
Breast Neoplasms
Angiotensin II activates extracellular signal regulated kinases via protein kinase C and epidermal growth factor receptor in breast cancer cells.
Breast Neoplasms
Antineoplaston induces G(1) arrest by PKCalpha and MAPK pathway in SKBR-3 breast cancer cells.
Breast Neoplasms
Antisense therapy directed to protein kinase C-alpha (Affinitak, LY900003/ISIS 3521): potential role in breast cancer.
Breast Neoplasms
aPKCi triggers basal extrusion of luminal mammary epithelial cells by tuning contractility and vinculin localization at cell junctions.
Breast Neoplasms
Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI Anticancer Drug Screen: multifactorial relationships with topoisomerase I, protein kinase C, Bcl-2, p53, MDM-2 and caspase pathways.
Breast Neoplasms
Association of PKC delta and active Src in PMA-treated MCF-7 human breast cancer cells.
Breast Neoplasms
Atypical PKC-zeta and PKC-iota mediate opposing effects on MCF-7 Na+/K+ATPase activity.
Breast Neoplasms
Aurora kinases are essential for PKC-induced invasion and matrix metalloproteinase-9 expression in MCF-7 breast cancer cells.
Breast Neoplasms
Biochemical requirements for the expression of heat shock protein 72 kda in human breast cancer MCF-7 cells.
Breast Neoplasms
Biological mechanisms in breast cancer invasiveness: relevance to preventive interventions.
Breast Neoplasms
Biosynthesis and posttranslational modifications of protein kinase C in human breast cancer cells.
Breast Neoplasms
Breast cancer cell invasiveness: correlation with protein kinase C activity and differential regulation by phorbol ester in estrogen receptor-positive and -negative cells.
Breast Neoplasms
Bryostatin 1 affects P-glycoprotein phosphorylation but not function in multidrug-resistant human breast cancer cells.
Breast Neoplasms
Calmodulin antagonism and growth-inhibiting activity of triphenylethylene antiestrogens in MCF-7 human breast cancer cells.
Breast Neoplasms
Cell growth inhibition by all-trans retinoic acid in SKBR-3 breast cancer cells: involvement of protein kinase Calpha and extracellular signal-regulated kinase mitogen-activated protein kinase.
Breast Neoplasms
Changes in diacylglycerol and membrane associated protein kinase C activity reflect the growth status of xenografted human mammary carcinoma treated with 8-Cl-cAMP.
Breast Neoplasms
Co-ordinate loss of protein kinase C and multidrug resistance gene expression in revertant MCF-7/Adr breast carcinoma cells.
Breast Neoplasms
Comparison between inhibition of protein kinase C and antagonism of calmodulin by tamoxifen analogues.
Breast Neoplasms
Continuous synthesis of two protein-kinase-C-related proteins after down-regulation by phorbol esters.
Breast Neoplasms
Contribution of protein kinase A and protein kinase C signalling pathways to the regulation of HSD11B2 expression and proliferation of MCF-7 cells.
Breast Neoplasms
Control of MT1-MMP transport by atypical PKC during breast-cancer progression.
Breast Neoplasms
Correction: Novel Antitumor Effect of Estradiol in Athymic Mice Injected with a T47D Breast Cancer Cell Line Overexpressing Protein Kinase C Alpha.
Breast Neoplasms
Cross Talk Mechanism among EMT, ROS, and Histone Acetylation in Phorbol Ester-Treated Human Breast Cancer MCF-7 Cells.
Breast Neoplasms
Crosstalk between miR-203 and PKC? regulates breast cancer stem cell markers.
Breast Neoplasms
Cyclooxygenase-2 utilizes Jun N-terminal kinases to induce invasion, but not tamoxifen resistance, in MCF-7 breast cancer cells.
Breast Neoplasms
Cyclooxygenase-2, P-glycoprotein-170 and drug resistance; is chemoprevention against multidrug resistance possible?
Breast Neoplasms
Cytotoxicity induced by manipulation of signal transduction pathways is associated with down-regulation of Bcl-2 but not Mcl-1 in MCF-7 human breast cancer.
Breast Neoplasms
Deregulation of PKB influences antiapoptotic signaling by PKC in breast cancer cells.
Breast Neoplasms
Development of a microscopy-based assay for protein kinase Czeta activation in human breast cancer cells.
Breast Neoplasms
Differences in protein kinase C and estrogen receptor alpha, beta expression and signaling correlate with apoptotic sensitivity of MCF-7 breast cancer cell variants.
Breast Neoplasms
Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status.
Breast Neoplasms
Differential effects of bryostatin 1 and phorbol ester on human breast cancer cell lines.
Breast Neoplasms
Differential effects of protein kinase C agonists on prostaglandin production and growth in human breast cancer cells.
Breast Neoplasms
Differential effects of protein kinase C-eta on apoptosis versus senescence.
Breast Neoplasms
Differential induction of apoptosis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A.
Breast Neoplasms
Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors.
Breast Neoplasms
Differential sensitivity of breast cancer cells to tumor necrosis factor-alpha: involvement of protein kinase C.
Breast Neoplasms
Differential subcellular expression of protein kinase C betaII in breast cancer: correlation with breast cancer subtypes.
Breast Neoplasms
Direct Binding and Activation of Protein Kinase C Isoforms by Aldosterone and 17{beta}-Estradiol.
Breast Neoplasms
Dissecting the 17?-estradiol pathways necessary for neuroglobin anti-apoptotic activity in breast cancer.
Breast Neoplasms
Distinct mechanisms mediate the initial and sustained phases of cell migration in epidermal growth factor receptor-overexpressing cells.
Breast Neoplasms
Distinct responses of protein kinase C isozymes to c-erbB-2 activation in SKBR-3 human breast carcinoma cells.
Breast Neoplasms
Down-regulation of 3-phosphoinositide-dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells.
Breast Neoplasms
Downregulation of Bid is associated with PKCepsilon-mediated TRAIL resistance.
Breast Neoplasms
Dual regulation of the epidermal growth factor family of growth factors in breast cancer by sex steroids and protein kinase C.
Breast Neoplasms
Dysregulation of protein kinase C activity in chemoresistant metastatic breast cancer cells.
Breast Neoplasms
Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion.
Breast Neoplasms
Effects of regulatory domains of specific isoforms of protein kinase C on growth control and apoptosis in MCF-7 breast cancer cells.
Breast Neoplasms
Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells.
Breast Neoplasms
Elevated levels of ERK2 in human breast carcinoma MCF-7 cells transfected with protein kinase C alpha.
Breast Neoplasms
Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure.
Breast Neoplasms
Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue.
Breast Neoplasms
Enhanced phosphorylation of progesterone receptor by protein kinase C in human breast cancer cells.
Breast Neoplasms
Enhancement of camptothecin-induced cytotoxicity with UCN-01 in breast cancer cells: abrogation of S/G(2) arrest.
Breast Neoplasms
Enzastaurin renders MCF-7 breast cancer cells sensitive to radiation through reversal of radiation-induced activation of protein kinase C.
Breast Neoplasms
Epidermal growth factor binding and protein kinase C activities in human breast cancer cell lines: possible quantitative relationship.
Breast Neoplasms
ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression.
Breast Neoplasms
Estrogen activates raf-1 kinase and induces expression of Egr-1 in MCF-7 breast cancer cells.
Breast Neoplasms
Estrogen-dependent rapid activation of protein kinase C in estrogen receptor-positive MCF-7 breast cancer cells and estrogen receptor-negative HCC38 cells is membrane-mediated and inhibited by tamoxifen.
Breast Neoplasms
Ets2 and protein kinase C epsilon are important regulators of parathyroid hormone-related protein expression in MCF-7 breast cancer cells.
Breast Neoplasms
Evaluation of 2,6-diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)- hexanamide (NPC 15437), a protein kinase C inhibitor, as a modulator of P-glycoprotein-mediated resistance in vitro.
Breast Neoplasms
Evidence for a role for protein kinase C in the modulation of bombesin-activated cellular signalling in human breast cancer cells.
Breast Neoplasms
Ex vivo assays to evaluate the role of protein kinase C in tumor cells of patients with breast cancer.
Breast Neoplasms
Exogenous CXCL12 activates protein kinase C to phosphorylate connexin 43 for gap junctional intercellular communication among confluent breast cancer cells.
Breast Neoplasms
Expression of protein kinase C-beta promotes the stimulatory effect of phorbol ester on phosphatidylethanolamine synthesis.
Breast Neoplasms
Expression of the antisense cDNA for protein kinase C alpha attenuates resistance in doxorubicin-resistant MCF-7 breast carcinoma cells.
Breast Neoplasms
Expression of the invasive phenotype by MCF-7 human breast cancer cells transfected to overexpress protein kinase C-alpha or the erbB2 proto-oncogene.
Breast Neoplasms
Extranuclear ER? is associated with regression of T47D PKC?-overexpressing, tamoxifen-resistant breast cancer.
Breast Neoplasms
Functional Doxorubicin-Loaded Omega-3 Unsaturated Fatty Acids Nanoparticles in Reversing Hepatocellular Carcinoma Multidrug Resistance.
Breast Neoplasms
Gene regulation by phorbol 12-myristate 13-acetate in MCF-7 and MDA-MB-231, two breast cancer cell lines exhibiting highly different phenotypes.
Breast Neoplasms
Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells.
Breast Neoplasms
Heterogeneity of proteinkinase C activity and PKC-zeta expression in clinical breast carcinomas.
Breast Neoplasms
Hormonal regulation of lactate dehydrogenase-A through activation of protein kinase C pathways in MCF-7 breast cancer cells.
Breast Neoplasms
Hormonal regulation of PKC: estrogen up-regulates PKCeta expression in estrogen-responsive breast cancer cells.
Breast Neoplasms
Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microrna-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells.
Breast Neoplasms
Immunohistochemical analysis of advanced human breast carcinomas reveals downregulation of protein kinase C alpha.
Breast Neoplasms
Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and -beta overexpression.
Breast Neoplasms
Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells.
Breast Neoplasms
Inhibition of PKC/MEK pathway suppresses ?1-integrin and mitigates breast cancer cells proliferation.
Breast Neoplasms
Integrin alpha 5 beta 1 suppresses apoptosis triggered by serum starvation but not phorbol ester in MCF-7 breast cancer cells that overexpress protein kinase C-alpha.
Breast Neoplasms
Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer.
Breast Neoplasms
Involvement of protein kinase C ? and ? activities on the induction of the retinoic acid system in mammary cancer cells.
Breast Neoplasms
Involvement of protein kinase C in the growth regulation of human breast cancer cells.
Breast Neoplasms
Isolation of protein kinase C-alpha-regulated cDNAs associated with breast tumor aggressiveness by differential mRNA display.
Breast Neoplasms
Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression.
Breast Neoplasms
Macrophage-elicited loss of estrogen receptor-? in breast cancer cells via involvement of MAPK and c-Jun at the ESR1 genomic locus.
Breast Neoplasms
MARCKSL1 promotes the proliferation, migration and invasion of lung adenocarcinoma cells.
Breast Neoplasms
MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.
Breast Neoplasms
Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta.
Breast Neoplasms
Membrane Estrogen Signaling Enhances Tumorigenesis and Metastatic Potential of Breast Cancer Cells via Estrogen Receptor-?36 (ER?36).
Breast Neoplasms
miR-615-3p promotes the epithelial-mesenchymal transition and metastasis of breast cancer by targeting PICK1/TGFBRI axis.
Breast Neoplasms
Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme selectivity.
Breast Neoplasms
Modulation of the antigenic phenotype of human breast carcinoma cells by modifiers of protein kinase C activity and recombinant human interferons.
Breast Neoplasms
Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases.
Breast Neoplasms
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
Breast Neoplasms
No tumor-specific expression levels of protein kinase C isoenzymes and of c-fos in human breast cancer cell cultures.
Breast Neoplasms
Novel antitumor effect of estradiol in athymic mice injected with a T47D breast cancer cell line overexpressing protein kinase Calpha.
Breast Neoplasms
Omega-3 fatty acids decrease protein kinase expression in human breast cancer cells.
Breast Neoplasms
Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model.
Breast Neoplasms
Overexpression of PKCalpha is required to impart estradiol inhibition and tamoxifen-resistance in a T47D human breast cancer tumor model.
Breast Neoplasms
Overexpression of protein kinase C-alpha in MCF-7 breast cancer cells results in differential regulation and expression of alphavbeta3 and alphavbeta5.
Breast Neoplasms
Overexpression of protein kinase C-eta attenuates caspase activation and tumor necrosis factor-alpha-induced cell death.
Breast Neoplasms
P2Y2 nucleotide receptor-mediated extracellular signal-regulated kinases and protein kinase C activation induces the invasion of highly metastatic breast cancer cells.
Breast Neoplasms
p34SEI-1 inhibits doxorubicin-induced senescence through a pathway mediated by protein kinase C-delta and c-Jun-NH2-kinase 1 activation in human breast cancer MCF7 cells.
Breast Neoplasms
Partial reversal of multidrug resistance in human breast cancer cells by an N-myristoylated protein kinase C-alpha pseudosubstrate peptide.
Breast Neoplasms
Phorbol ester stimulation of phosphatidylcholine synthesis requires expression of both protein kinase C-alpha and phospholipase D.
Breast Neoplasms
Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death.
Breast Neoplasms
Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation.
Breast Neoplasms
Phosphorylation of alpha 6-tubulin by protein kinase Calpha activates motility of human breast cells.
Breast Neoplasms
PKC activation sensitizes basal-like breast cancer cell lines to Smac mimetics.
Breast Neoplasms
PKC?/? signaling promotes triple-negative breast cancer growth and metastasis.
Breast Neoplasms
PKCdelta and MAPK mediate G(1) arrest induced by PMA in SKBR-3 breast cancer cells.
Breast Neoplasms
PKCtheta promotes c-Rel-driven mammary tumorigenesis in mice and humans by repressing estrogen receptor alpha synthesis.
Breast Neoplasms
Polycyclic aromatic hydrocarbon o-quinones inhibit the activity of the catalytic fragment of protein kinase C.
Breast Neoplasms
Potentiation of genomic actions of estrogen by membrane actions in mcf-7 cells and the involvement of protein kinase C activation.
Breast Neoplasms
Preclinical and clinical studies of novel breast cancer drugs targeting molecules involved in protein kinase C signaling, the putative metastasis-suppressor gene Cap43 and the Y-box binding protein-1.
Breast Neoplasms
Preclinical studies of molecular-targeting diagnostic and therapeutic strategies against breast cancer.
Breast Neoplasms
Preferential star strand biogenesis of pre-miR-24-2 targets PKC-alpha and suppresses cell survival in MCF-7 breast cancer cells.
Breast Neoplasms
Prognostic significance of mRNA-encoding estrogen receptor and epithelial growth factor receptor in breast carcinoma progression into lymph nodes: 1. Estrogen receptor encoding mRNA.
Breast Neoplasms
Proliferation of human breast cancer cells and anti-cancer action of doxorubicin and vinblastine are independent of PKC-alpha.
Breast Neoplasms
Protein interacting with C alpha kinase 1 (PICK1) is involved in promoting tumor growth and correlates with poor prognosis of human breast cancer.
Breast Neoplasms
Protein kinase C ? enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin.
Breast Neoplasms
Protein Kinase C ? Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells.
Breast Neoplasms
Protein kinase C ? regulates nuclear pri-microRNA 15a release as part of endothelin signaling.
Breast Neoplasms
Protein kinase C ?-dependent regulation of Ubiquitin-proteasome system function in breast cancer.
Breast Neoplasms
Protein Kinase C Alpha (PKC?) overexpression leads to a better response to retinoid acid therapy through Retinoic Acid Receptor Beta (RAR?) activation in mammary cancer cells.
Breast Neoplasms
Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer.
Breast Neoplasms
Protein Kinase C alpha is a marker for antiestrogen resistance and is involved in the growth of tamoxifen resistant human breast cancer cells.
Breast Neoplasms
Protein kinase C and its isoforms in human breast cancer cells: relationship to the invasive phenotype.
Breast Neoplasms
Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cells.
Breast Neoplasms
Protein kinase C Beta in the tumor microenvironment promotes mammary tumorigenesis.
Breast Neoplasms
Protein kinase C delta enhances proliferation and survival of murine mammary cells.
Breast Neoplasms
Protein kinase C delta is a prosurvival factor in human breast tumor cell lines.
Breast Neoplasms
Protein kinase C delta mediates platelet-induced breast cancer cell invasion.
Breast Neoplasms
Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells.
Breast Neoplasms
Protein kinase C epsilon confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53.
Breast Neoplasms
Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy.
Breast Neoplasms
Protein kinase C involvement in proliferation and survival of breast cancer cells.
Breast Neoplasms
Protein kinase C isoform expression as a predictor of disease outcome on endocrine therapy in breast cancer.
Breast Neoplasms
Protein kinase C subspecies in estrogen receptor-positive and -negative human breast cancer cell lines.
Breast Neoplasms
Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells.
Breast Neoplasms
Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.
Breast Neoplasms
Protein kinase C? and caspase-3 modulate TRAIL-induced apoptosis in breast tumor cells.
Breast Neoplasms
Protein kinase C? is required for ErbB2-driven mammary gland tumorigenesis and negatively correlates with prognosis in human breast cancer.
Breast Neoplasms
Protein kinase C? suppresses the expression of STC1 in MDA-MB-231 breast cancer cells.
Breast Neoplasms
Protein kinase Calpha determines HER2 fate in breast carcinoma cells with HER2 protein overexpression without gene amplification.
Breast Neoplasms
Protein kinase Calpha expression confers retinoic acid sensitivity on MDA-MB-231 human breast cancer cells.
Breast Neoplasms
Protein kinase Calpha negatively regulates cell spreading and motility in MDA-MB-231 human breast cancer cells downstream of epidermal growth factor receptor.
Breast Neoplasms
Protein kinase Calpha regulates Ets1 transcriptional activity in invasive breast cancer cells.
Breast Neoplasms
Protein Kinase C{epsilon} Mediates Polymeric Fibronectin Assembly on the Surface of Blood-borne Rat Breast Cancer Cells to Promote Pulmonary Metastasis.
Breast Neoplasms
Protein kinases C isozymes are differentially expressed in human breast carcinomas.
Breast Neoplasms
Quantitative chemical proteomics in small-scale culture of phorbol ester stimulated basal breast cancer cells.
Breast Neoplasms
Reduced expression of Wnt-1 and E-cadherin, and diminished beta-catenin stability in MCF-7 breast cancer cells that overexpress protein kinase C-alpha.
Breast Neoplasms
Regulation of arachidonic acid metabolism, aromatase activity and growth in human breast cancer cells by interleukin-1beta and phorbol ester: dissociation of a mediatory role for prostaglandin E2 in the autocrine control of cell function.
Breast Neoplasms
Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes alpha and theta.
Breast Neoplasms
Regulation of motility and protease expression in PKC-mediated induction of MCF-7 breast cancer cell invasiveness.
Breast Neoplasms
Regulation of protein kinase C delta by estrogen in the MCF-7 human breast cancer cell line.
Breast Neoplasms
Regulation of the adhesion of a human breast carcinoma cell line to type IV collagen and vitronectin: roles for lipoxygenase and protein kinase C.
Breast Neoplasms
Relative involvement of protein kinase C and of the estrogen receptor in the cytotoxic action of a population of triphenylethylenes on MCF7 cells as revealed by correspondence factorial (CF) analysis.
Breast Neoplasms
Requirement of protein kinase C micro activation and calpain-mediated proteolysis for arachidonic acid-stimulated adhesion of MDA-MB-435 human mammary carcinoma cells to collagen type IV.
Breast Neoplasms
Retinoic acid induced growth arrest of human breast carcinoma cells requires protein kinase C alpha expression and activity.
Breast Neoplasms
Role of PKC-ERK signaling in tamoxifen-induced apoptosis and tamoxifen resistance in human breast cancer cells.
Breast Neoplasms
Role of protein kinase C in the modulation of multidrug resistance: expression of the atypical gamma isoform of protein kinase C does not confer increased resistance to doxorubicin.
Breast Neoplasms
Selective inhibition of the effects of phorbol ester on doxorubicin resistance and P-glycoprotein by the protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7) in multidrug-resistant MCF-7/Dox human breast carcinoma cells.
Breast Neoplasms
Selective modulation of protein kinase A and protein kinase C activities in epidermal growth factor (EGF)-stimulated MCF-7 breast cancer cells.
Breast Neoplasms
Sensitization of human breast cancer cells to gemcitabine by the protein kinase C modulator bryostatin 1.
Breast Neoplasms
Signalling-competent truncated forms of ErbB2 in breast cancer cells: differential regulation by protein kinase C and phosphatidylinositol 3-kinase.
Breast Neoplasms
Silencing of casein kinase 2 inhibits PKC?induced cell invasion by targeting MMP?9 in MCF?7 cells.
Breast Neoplasms
Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis.
Breast Neoplasms
Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines.
Breast Neoplasms
Supplementation of MCF-7 cells with essential fatty acids induces the activation of protein kinase C in response to IGF-1.
Breast Neoplasms
Sustained inhibition of PKC? reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model.
Breast Neoplasms
Tamoxifen induces selective membrane association of protein kinase C epsilon in MCF-7 human breast cancer cells.
Breast Neoplasms
Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells.
Breast Neoplasms
Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells.
Breast Neoplasms
Telomerase is controlled by protein kinase Calpha in human breast cancer cells.
Breast Neoplasms
The 27,000 daltons stress proteins are phosphorylated by protein kinase C during the tumor promoter-mediated growth inhibition of human mammary carcinoma cells.
Breast Neoplasms
The increase in cytosolic levels of protein kinase C precedes the growth factor requirements during the transition stem cells to differentiated progeny in the MCF-7 breast tumor cells.
Breast Neoplasms
The involvement of novel protein kinase C isozymes in influencing sensitivity of breast cancer MCF-7 cells to tumor necrosis factor-alpha.
Breast Neoplasms
The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors.
Breast Neoplasms
The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells.
Breast Neoplasms
Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha.
Breast Neoplasms
Type V collagen and protein kinase C ? down-regulation in 8701-BC breast cancer cells.
Breast Neoplasms
Unravelling Structure, Localization, and Genetic Crosstalk of KLF3 in Human Breast Cancer.
Breast Neoplasms
Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors.
Breast Neoplasms
Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells.
Breast Neoplasms
[Effects of inhibition of PKC alpha on breast cancer cell phenotype and expressions of cyclin E and CDK2]
Bronchiolitis Obliterans
Anti-airway epithelial cell antibody binding results in protein kinase C activation and fibrotic growth factor production contributing to pathogenesis of bronchiolitis obliterans.
Burkholderia Infections
PKC-?-MARCKS Signaling Promotes Intracellular Survival of Unopsonized Burkholderia thailandensis.
Burkitt Lymphoma
Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: Relationship between its expression and prognosis.
Burkitt Lymphoma
The phosphoprotein phosphatase calcineurin controls calcium-dependent apoptosis in B cell lines.
Carcinogenesis
"Expression of protein kinase C isoforms in cancerous breast tissue and adjacent normal breast tissue".
Carcinogenesis
1,2-sn-diacylglycerol accumulates in choline-deficient liver. A possible mechanism of hepatic carcinogenesis via alteration in protein kinase C activity?
Carcinogenesis
A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma.
Carcinogenesis
A new concept of tumor promotion by tumor necrosis factor-alpha, and cancer preventive agents (-)-epigallocatechin gallate and green tea--a review.
Carcinogenesis
A new mechanism of SOX9 action to regulate PKCalpha expression in the intestine epithelium.
Carcinogenesis
Actions of a tumor-promoting phorbol ester in a cloned rat pituitary cell : Potential involvement of changes in Ca(2+) metabolism.
Carcinogenesis
Adenoma-specific alterations of protein kinase C isozyme expression in Apc(MIN) mice.
Carcinogenesis
Alterations in protein kinase C in 1,2-dimethylhydrazine induced colonic carcinogenesis.
Carcinogenesis
Analyses of protein kinase C isoform expression in a colorectal cancer liver metastasis model.
Carcinogenesis
Antisense strategies targeting protein kinase C: preclinical and clinical development.
Carcinogenesis
Antisense targeting protein kinase C alpha and beta1 inhibits gastric carcinogenesis.
Carcinogenesis
Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells.
Carcinogenesis
Arachidonic acid metabolism in benign and malignant prostatic tissue in vitro: effects of fatty acids and cyclooxygenase inhibitors.
Carcinogenesis
Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer.
Carcinogenesis
Breast cancer cell invasiveness: correlation with protein kinase C activity and differential regulation by phorbol ester in estrogen receptor-positive and -negative cells.
Carcinogenesis
c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis.
Carcinogenesis
Changes in carboxylesterase isoenzymes of rat liver microsomes during hepatocarcinogenesis.
Carcinogenesis
Changes in protein kinase C alpha, delta and in nuclear beta isoform expression in tumour and lung metastatic nodules induced by diethylnitrosamine in the rat.
Carcinogenesis
Characterization of PKC2, a gene encoding a second protein kinase C isotype of Saccharomyces cerevisiae.
Carcinogenesis
Characterization of the role of protein kinase C isozymes in colon carcinogenesis using transgenic mouse models.
Carcinogenesis
Cholesterol sulfate, a second messenger for the eta isoform of protein kinase C, inhibits promotional phase in mouse skin carcinogenesis.
Carcinogenesis
Clueless regulates aPKC activity and promotes self-renewal cell fate in Drosophila lgl mutant larval brains.
Carcinogenesis
Computer-assisted molecular modeling of tumor promoters: rationale for the activity of phorbol esters, teleocidin B, and aplysiatoxin.
Carcinogenesis
Decrease in the protein kinase C-catalyzed phosphorylation of an endogenous lung protein (Mr 36,000) following treatment of mice with the tumor-modulatory agent butylated hydroxytoluene.
Carcinogenesis
Deficiency of protein kinase Calpha in mice results in impairment of epidermal hyperplasia and enhancement of tumor formation in two-stage skin carcinogenesis.
Carcinogenesis
Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate.
Carcinogenesis
Dexniguldipine hydrochloride inhibits growth of human ht-29 colon-carcinoma cells and expression of protein-kinase-C-delta and protein-kinase-C-zeta.
Carcinogenesis
Dexniguldipine hydrochloride inhibits growth of human pancreatic adenocarcinoma cells and expression of protein kinase C isoforms alpha and zeta.
Carcinogenesis
Dietary lipid varying in corn and coconut oil influences protein kinase C in phorbol ester-treated mouse skin.
Carcinogenesis
Dietary modulation of epidermal protein kinase C: mediation by diacylglycerol.
Carcinogenesis
Differential expression of protein kinase C isoforms in diethylnitrosamine-initiated rat liver.
Carcinogenesis
Direct interaction of all-trans-retinoic acid with protein kinase C (PKC). Implications for PKC signaling and cancer therapy.
Carcinogenesis
Disparity in expression of protein kinase C alpha in human glioma versus glioma-derived primary cell lines: therapeutic implications.
Carcinogenesis
Ectopic expression of a mutant form of PKCalpha originally found in human tumors: aberrant subcellular translocation and effects on growth control.
Carcinogenesis
Effect of amount and types of dietary fat on intestinal bacterial 7 alpha-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during stages of colon tumor promotion.
Carcinogenesis
Effect of diterpene esters on actin cytoskeleton of SV40-transformed keratinocytes is not reproduced by diacylglycerols.
Carcinogenesis
Effects of a flaxseed mixture and plant oils rich in alpha-linolenic acid on the adenoma formation in multiple intestinal neoplasia (Min) mice.
Carcinogenesis
Effects of a long-chain fatty amine on mammary carcinogenesis induced in female Sprague-Dawley rats by DMBA.
Carcinogenesis
Effects of activators and inhibitors of protein kinase C on two-stage transformation in BALB/3T3 cells.
Carcinogenesis
Effects of acute vs. chronic phorbol ester exposure on transepithelial permeability and epithelial morphology.
Carcinogenesis
Effects of regulatory domains of specific isoforms of protein kinase C on growth control and apoptosis in MCF-7 breast cancer cells.
Carcinogenesis
Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis.
Carcinogenesis
Endometrial cancer cell survival and apoptosis is regulated by protein kinase C alpha and delta.
Carcinogenesis
Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells.
Carcinogenesis
Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C.
Carcinogenesis
Expression of multiple isoforms of protein kinase C in normal human colon mucosa and colon tumors and decreased levels of protein kinase C beta and eta mRNAs in the tumors.
Carcinogenesis
Expression of P-aPKC-iota, E-cadherin, and beta-catenin related to invasion and metastasis in hepatocellular carcinoma.
Carcinogenesis
Extracellular pyruvate kinase M2 facilitates cell migration by upregulating claudin-1 expression in colon cancer cells.
Carcinogenesis
From amplification to gene in thyroid cancer: a high-resolution mapped bacterial-artificial-chromosome resource for cancer chromosome aberrations guides gene discovery after comparative genome hybridization.
Carcinogenesis
Fumonisin B1 induces protein kinase C translocation via direct interaction with diacylglycerol binding site.
Carcinogenesis
Gender-specific and developmental differences in protein kinase C isozyme expression in rat liver.
Carcinogenesis
Generating Conformation-Specific Polyclonal and Monoclonal Anti-Protein Kinase C Antibodies and Anti-Active State Specific PKC Antibodies.
Carcinogenesis
Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma.
Carcinogenesis
Genomic organization and chromosomal localization of the mouse protein kinase C alpha gene.
Carcinogenesis
HCCRBP-1 directly interacting with HCCR-1 induces tumorigenesis through P53 stabilization.
Carcinogenesis
High-fat diet blocks the inhibition of skin carcinogenesis and reductions in protein kinase C by moderate energy restriction.
Carcinogenesis
Human prostate cell lines from normal and tumourigenic epithelia differ in the pattern and control of choline lipid headgroups released into the medium on stimulation of protein kinase C.
Carcinogenesis
Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.
Carcinogenesis
Immortalized mammary epithelial cells overexpressing protein kinase C gamma acquire a malignant phenotype and become tumorigenic in vivo.
Carcinogenesis
Immunochemical localization of protein kinase Calpha in the biopsies of human hepatocellular carcinoma.
Carcinogenesis
In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites.
Carcinogenesis
Increased protein kinase C delta in mammary tumor cells: relationship to transformtion and metastatic progression.
Carcinogenesis
Influence of ionizing radiation on induction of apoptotic cell death and cellular redistribution of protein kinase C isozymes in mouse epidermal cells differing in carcinogenesis stages.
Carcinogenesis
Inhibition of 12-O-tetradecanoyl phorbol-13-acetate promoted tumorigenesis by cepharanthine, a biscoclaurine alkaloid, in relation to the inhibitory effect on protein kinase C.
Carcinogenesis
Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).
Carcinogenesis
Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells.
Carcinogenesis
Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.
Carcinogenesis
K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling.
Carcinogenesis
Kinase gene expression and subcellular protein expression pattern of protein kinase C isoforms in curcumin-treated human hepatocellular carcinoma Hep 3B cells.
Carcinogenesis
Lack of protein kinase C (PKC)-beta and low PKC-alpha, -delta, -epsilon, and -zeta isozyme levels in proliferating human melanoma cells.
Carcinogenesis
Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: potential roles of protein kinase C-alpha, -beta II, and -zeta.
Carcinogenesis
Mechanisms in the chemoprevention of colon cancer: modulation of protein kinase C, tyrosine protein kinase and diacylglycerol kinase activities by 1,4-phenylenebis-(methylene)selenocyanate and impact of low-fat diet.
Carcinogenesis
Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic Ras.
Carcinogenesis
Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol.
Carcinogenesis
Molecular mechanisms of the cross-impact of pathological processes in combined diabetes and cancer. Research and clinical aspects.
Carcinogenesis
NF-kappaB regulates androgen receptor expression and prostate cancer growth.
Carcinogenesis
Nicotine enhances the malignant potential of human pancreatic cancer cells via activation of atypical protein kinase C.
Carcinogenesis
Non-invasive detection of fecal protein kinase C betaII and zeta messenger RNA: putative biomarkers for colon cancer.
Carcinogenesis
Noninvasive detection of putative biomarkers for colon cancer using fecal messenger RNA.
Carcinogenesis
Nonmutagenic mechanisms in carcinogenesis: role of protein kinase C in signal transduction and growth control.
Carcinogenesis
Opposite roles of protein kinase C isoforms in proliferation, differentiation, apoptosis, and tumorigenicity of human HaCaT keratinocytes.
Carcinogenesis
Over-expression of protein kinase C delta is associated with a delay in preneoplastic lesion development in diethylnitrosamine-induced rat hepatocarcinogenesis.
Carcinogenesis
Over-expression of protein kinase C?isoforms (?, ?, ? and ?) in squamous cervical cancer.
Carcinogenesis
Overexpression of PAK-1 is an independent predictor of disease recurrence in colorectal carcinoma.
Carcinogenesis
Overexpression of protein kinase C alpha mRNA in human hepatocellular carcinoma: a potential marker of disease prognosis.
Carcinogenesis
Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis.
Carcinogenesis
p38 mitogen-activated protein kinase pathway is involved in protein kinase Calpha-regulated invasion in human hepatocellular carcinoma cells.
Carcinogenesis
Phase I dose escalation study of the PKC? inhibitor aurothiomalate for advanced non-small-cell lung cancer, ovarian cancer, and pancreatic cancer.
Carcinogenesis
PKC inhibition increases gap junction intercellular communication and cell adhesion in human neuroblastoma.
Carcinogenesis
PKC iota promotes cellular proliferation by accelerated G1/S transition via interaction with CDK7 in esophageal squamous cell carcinoma.
Carcinogenesis
PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1.
Carcinogenesis
PKCdelta acts as a growth and tumor suppressor in rat colonic epithelial cells.
Carcinogenesis
PKCiota promotes ovarian tumor progression through deregulation of cyclin E.
Carcinogenesis
PKCtheta promotes c-Rel-driven mammary tumorigenesis in mice and humans by repressing estrogen receptor alpha synthesis.
Carcinogenesis
Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells.
Carcinogenesis
Promoting phorbol ester-TPA enhances migration of C3H 10T1/2 cells. The role of protein kinase C and its relation to carcinogenesis.
Carcinogenesis
Protein interacting with C kinase 1 suppresses invasion and anchorage-independent growth of astrocytic tumor cells.
Carcinogenesis
Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway.
Carcinogenesis
Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression.
Carcinogenesis
Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice.
Carcinogenesis
Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis.
Carcinogenesis
Protein kinase C and prostate carcinogenesis: targeting the cell cycle and apoptotic mechanisms.
Carcinogenesis
Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cells.
Carcinogenesis
Protein kinase C Beta in the tumor microenvironment promotes mammary tumorigenesis.
Carcinogenesis
Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression.
Carcinogenesis
Protein kinase C betaII and TGFbetaRII in omega-3 fatty acid-mediated inhibition of colon carcinogenesis.
Carcinogenesis
Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators.
Carcinogenesis
Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway.
Carcinogenesis
Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner.
Carcinogenesis
Protein kinase C epsilon signals ultraviolet light-induced cutaneous damage and development of squamous cell carcinoma possibly through Induction of specific cytokines in a paracrine mechanism.
Carcinogenesis
Protein kinase C eta (PKC eta): its involvement in keratinocyte differentiation.
Carcinogenesis
Protein kinase C in Wnt signaling: Implications in cancer initiation and progression.
Carcinogenesis
Protein kinase C isoforms in the chemopreventive effects of a novel vitamin D3 analogue in rat colonic tumorigenesis.
Carcinogenesis
Protein kinase C tissue localization in human colonic tumors suggests a role for adenoma growth control.
Carcinogenesis
Protein Kinase C {delta} Is a Downstream Effector of Oncogenic K-ras in Lung Tumors.
Carcinogenesis
Protein kinase Calpha puts the hand cuffs on epidermal keratinocyte proliferation.
Carcinogenesis
Protein kinase Cbeta is an effective target for chemoprevention of colon cancer.
Carcinogenesis
Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo.
Carcinogenesis
Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer.
Carcinogenesis
Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo.
Carcinogenesis
Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo.
Carcinogenesis
Protein Kinase-zeta inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells.
Carcinogenesis
Purification and identification of creatine phosphokinase B as a substrate of protein kinase C in mouse skin in vivo.
Carcinogenesis
Quantitative trait locus mapping of genes regulating pulmonary PKC activity and PKC-alpha content.
Carcinogenesis
Reexpression of the major protein kinase C substrate, SSeCKS, suppresses v-src-induced morphological transformation and tumorigenesis.
Carcinogenesis
Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor-promotion susceptibilities of protein kinase C alpha, -delta and -epsilon transgenic mice.
Carcinogenesis
Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of ?-Catenin and Yap by PKC?
Carcinogenesis
Resveratrol preferentially inhibits protein kinase C-catalyzed phosphorylation of a cofactor-independent, arginine-rich protein substrate by a novel mechanism.
Carcinogenesis
Role of cyclooxygenase 2 in protein kinase C beta II-mediated colon carcinogenesis.
Carcinogenesis
scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs.
Carcinogenesis
Selective and transient activation of protein kinase C alpha by fumonisin B1, a ceramide synthase inhibitor mycotoxin, in cultured porcine renal cells.
Carcinogenesis
Signal transduction mechanism in response to aflatoxin B1 exposure: protein kinase C activity.
Carcinogenesis
Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis.
Carcinogenesis
Stimulation of cell proliferation and inhibition of differentiation expression by tumor-promoting phorbol esters in dog thyroid cells in primary culture.
Carcinogenesis
Stimulation of prostaglandin E2 production and induction of specific protein synthesis in rat peritoneal macrophages by a tumor promoter staurosporine.
Carcinogenesis
Suppression of calphobindin I (CPB I) production in carcinoma of uterine cervix and endometrium.
Carcinogenesis
Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells.
Carcinogenesis
Tamoxifen suppresses tumor promoter-induced hydrogen peroxide formation by human neutrophils.
Carcinogenesis
The identification of four protein kinase C isoforms in human glioblastoma cell lines: PKC alpha, gamma, epsilon, and zeta.
Carcinogenesis
The influence of dietary fat on carcinogenesis: lessons from experimental models.
Carcinogenesis
The long noncoding RNA lncZic2 drives the self-renewal of liver tumor-initiating cells via the protein kinase C substrates MARCKS and MARCKSL1.
Carcinogenesis
The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2.
Carcinogenesis
The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer.
Carcinogenesis
The role of activation-induced cytidine deaminase expression in gastric adenocarcinoma.
Carcinogenesis
The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).
Carcinogenesis
The role of protein kinase C in growth control and the concept of carcinogenesis as a progressive disorder in signal transduction.
Carcinogenesis
The therapeutic role of targeting protein kinase C in solid and hematologic malignancies.
Carcinogenesis
Timing of dietary fat exposure and mammary tumorigenesis: role of estrogen receptor and protein kinase C activity.
Carcinogenesis
Transcription factor Sp1 is upregulated by PKC? to drive the expression of YAP1 during pancreatic carcinogenesis.
Carcinogenesis
Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha.
Carcinogenesis
Transformation-sensitive changes in expression, localization, and phosphorylation of adducins in renal proximal tubule epithelial cells.
Carcinogenesis
Tumor grade-dependent alterations in the protein kinase C isoform pattern in urinary bladder carcinomas.
Carcinogenesis
Upregulation of the EP1 receptor for prostaglandin E(2) promotes skin tumor progression.
Carcinogenesis
Ursodeoxycholic acid inhibits interleukin 1 beta [corrected] and deoxycholic acid-induced activation of NF-kappaB and AP-1 in human colon cancer cells.
Carcinogenesis
Ursodeoxycholic acid inhibits translocation of protein kinase C in human colonic cancer cell lines.
Carcinogenesis
Wnt5a is associated with cigarette smoke-related lung carcinogenesis via protein kinase C.
Carcinogenesis
[The actions of TPA-type as well as non-TPA type tumor promoters and their mechanism(s) in tumor promotion]
Carcinogenesis
[The role of lipid metabolism disorders, atypical isoforms of protein kinase C, and mutational status of cytosolic and mitochondrial forms of isocitrate dehydrogenase in carcinogenesis of glial tumors].
Carcinoid Tumor
Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor.
Carcinoma
12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha.
Carcinoma
A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle.
Carcinoma
A Gynecologic Oncology Group phase II trial of the protein kinase C-beta inhibitor, enzastaurin and evaluation of markers with potential predictive and prognostic value in persistent or recurrent epithelial ovarian and primary peritoneal malignancies.
Carcinoma
A Phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C alpha, administered as a 21-day infusion to patients with advanced ovarian carcinoma.
Carcinoma
A role for protein kinase C in the multidrug resistance phenotype of human carcinoma KB cell lines.
Carcinoma
Activation by Tyrosine Phosphorylation as a Prerequisite for Protein Kinase C{zeta} to Mediate Epidermal Growth Factor Receptor Signaling to ERK.
Carcinoma
Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation.
Carcinoma
Activation of glomerular mesangial cells by hepatocyte growth factor through tyrosine kinase and protein kinase C.
Carcinoma
Activation of ion transport by combined effects of ionomycin, forskolin and phorbol ester on cultured HT-29cl.19A human colonocytes.
Carcinoma
Activation of Protein Kinase C ? in Merkel Cell Polyomavirus-Induced Merkel Cell Carcinoma.
Carcinoma
Activation of protein kinase C modulates cell-cell and cell-substratum adhesion of a human colorectal carcinoma cell line and restores 'normal' epithelial morphology.
Carcinoma
Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta.
Carcinoma
Agonist-induced desensitization of cholinergically stimulated phosphoinositide breakdown is independent of endogenously activated protein kinase C in HT-29 human colon carcinoma cells.
Carcinoma
Akt, protein kinase C, and mitogen-activated protein kinase phosphorylation status in head and neck squamous cell carcinoma.
Carcinoma
Alterations in levels of different protein kinase C isotypes and their influence on behavior of squamous cell carcinoma of the oral cavity: epsilon PKC, a novel prognostic factor for relapse and survival.
Carcinoma
Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas.
Carcinoma
Altered protein kinase C activity in biopsies of human colonic adenomas and carcinomas.
Carcinoma
Antiproliferative effects of interferon alpha on human pancreatic carcinoma cell lines are associated with differential regulation of protein kinase C isoenzymes.
Carcinoma
Antisense inhibition of protein kinase Calpha reverses the transformed phenotype in human lung carcinoma cells.
Carcinoma
Antisense oligonucleotides targeting human protein kinase C-alpha inhibit phorbol ester-induced reduction of bradykinin-evoked calcium mobilization in A549 cells.
Carcinoma
Antitumor activity of enzastaurin as radiation sensitizer in head and neck squamous cell carcinoma.
Carcinoma
Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines.
Carcinoma
Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells.
Carcinoma
aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia.
Carcinoma
Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells.
Carcinoma
Associated expression of protein kinase C with resistance to doxorubicin in human lung cancer.
Carcinoma
Atypical Protein Kinase C ?/? Expression Is Associated with Malignancy of Oral Squamous Cell Carcinoma.
Carcinoma
Atypical protein kinase C zeta exhibits a proapoptotic function in ovarian cancer.
Carcinoma
Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells.
Carcinoma
Bile acids modulate the Golgi membrane fission process via a protein kinase Ceta and protein kinase D-dependent pathway in colonic epithelial cells.
Carcinoma
Biphasic effects of 12-O-tetradecanoylphorbol-13-acetate on the cell morphology of low calcium-grown human epidermal carcinoma cells: involvement of translocation and down regulation of protein kinase C.
Carcinoma
Butyrate-induced alterations of phosphoinositide metabolism, protein kinase C activity and reduced CD44 variant expression in HT-29 colon cancer cells.
Carcinoma
Calcium-activated, phospholipid-dependent protein kinase in human gastric mucosa and carcinoma.
Carcinoma
Changes in diacylglycerol and membrane associated protein kinase C activity reflect the growth status of xenografted human mammary carcinoma treated with 8-Cl-cAMP.
Carcinoma
Changes in protein kinase C subspecies protein expression and activity in a series of multidrug-resistant human KB carcinoma cell lines.
Carcinoma
Characterization of the protein kinase C signal transduction pathway in cisplatin-sensitive and -resistant human small cell lung carcinoma cells.
Carcinoma
Chloride secretion induced by phorbol dibutyrate and forskolin in the human colonic carcinoma cell line HT-29Cl.19A is regulated by different mechanisms.
Carcinoma
Comparison of effects of bryostatins 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells.
Carcinoma
Comparison of protein kinase C activity and isoform expression in cisplatin-sensitive and -resistant ovarian carcinoma cells.
Carcinoma
Comparison of the effects of auranofin and retinoic acid on plasminogen activator activity of peritoneal macrophages and Lewis lung carcinoma cells.
Carcinoma
Constitutive presence of a catalytic fragment of protein kinase C epsilon in a small cell lung carcinoma cell line.
Carcinoma
Correlation between cell-cell contact formation and activation of protein kinase C in a human squamous cell carcinoma cell line.
Carcinoma
Correlation of protein kinase C translocation, P-glycoprotein phosphorylation and reduced drug accumulation in multidrug resistant human KB cells.
Carcinoma
Depletion of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances platinum drug sensitivity in human ovarian carcinoma cells.
Carcinoma
Dexniguldipine hydrochloride inhibits growth of human ht-29 colon-carcinoma cells and expression of protein-kinase-C-delta and protein-kinase-C-zeta.
Carcinoma
Different biological effects of the two protein kinase C activators bryostatin-1 and TPA on human carcinoma cell lines.
Carcinoma
Different expression patterns of calpain isozymes 1 and 2 (CAPN1 and 2) in squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) of human skin.
Carcinoma
Differential effects of melatonin and its downstream effector PKCalpha on subcellular localization of RGS proteins.
Carcinoma
Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation.
Carcinoma
Differential growth regulation by all-trans retinoic acid is determined by protein kinase C alpha in human pancreatic carcinoma cells.
Carcinoma
Differentially expressed mRNAs in androgen-independent but not androgen-dependent Shionogi carcinoma.
Carcinoma
Differentiation of pancreatic ductal carcinoma cells associated with selective expression of protein kinase C isoforms.
Carcinoma
Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases.
Carcinoma
Distinct effects of protein kinase C on the barrier function at different developmental stages.
Carcinoma
DOG1 Utility in diagnosing gastrointestinal stromal tumors on fine-needle aspiration.
Carcinoma
Down-regulation of protein kinase Ceta by antisense oligonucleotides sensitises A549 lung cancer cells to vincristine and paclitaxel.
Carcinoma
Downregulation of protein kinase C suppresses induction of apoptosis in human prostatic carcinoma cells.
Carcinoma
Dual Function of Protein Kinase C (PKC) in 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced Manganese Superoxide Dismutase (MnSOD) Expression: ACTIVATION OF CREB AND FOXO3a BY PKC-{alpha} PHOSPHORYLATION AND BY PKC-MEDIATED INACTIVATION OF Akt, RESPECTIVELY.
Carcinoma
Dual role for protein kinase C alpha as a regulator of ion secretion in the HT29cl.19A human colonic cell line.
Carcinoma
Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice.
Carcinoma
Ectopic Expression of Protein Kinase C-? Sensitizes Head and Neck Squamous Cell Carcinoma to Diterpene Esters.
Carcinoma
Effect of 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) on HSP70 and HSP28 gene expression and thermotolerance development in human colon carcinoma cells.
Carcinoma
Effect of protein kinase C alpha, caspase-3, and survivin on apoptosis of oral cancer cells induced by staurosporine.
Carcinoma
Effects of activators of protein kinase C, including bryostatins 1 and 2, on the growth of A549 human lung carcinoma cells.
Carcinoma
Effects of marine sponge extracts on mitogen-activated protein kinase (MAPK/ERK(1,2)) activity in SW-13 human adrenal carcinoma cells.
Carcinoma
Effects of protein kinase C inhibitor, staurosporine derivative CGP 41 251, on cell cycle, DNA synthesis and drug uptake in neoplastic cell lines.
Carcinoma
Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context.
Carcinoma
Endothelin receptor blockade potentiates FasL-induced apoptosis in colon carcinoma cells via the protein kinase C-pathway.
Carcinoma
Enhancement of anchorage-independent growth of human pancreatic carcinoma MIA PaCa-2 cells by signaling from protein kinase C to mitogen-activated protein kinase.
Carcinoma
Enhancement of sensitivity to platinum(II)-containing drugs by 12-O-tetradecanoyl-phorbol-13-acetate in a human ovarian carcinoma cell line.
Carcinoma
Epidermal growth factor increases 32P incorporation into phosphatidylcholine and protein kinase C activity in colon carcinoma cell line (HT29).
Carcinoma
Epidermal growth factor regulates topoisomerase II activity and drug sensitivity in human KB cells.
Carcinoma
Epsilon PKC acts like a marker of progressive malignancy in rat liver, but fails to enhance tumorigenesis in rat hepatoma cells in culture.
Carcinoma
Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement.
Carcinoma
Expression of multiple isoforms of protein kinase C in normal human colon mucosa and colon tumors and decreased levels of protein kinase C beta and eta mRNAs in the tumors.
Carcinoma
Expression of protein kinase C beta1 confers resistance to TNFalpha- and paclitaxel-induced apoptosis in HT-29 colon carcinoma cells.
Carcinoma
Expression of protein kinase C in human renal cell carcinoma cells with inherent resistance to doxorubicin.
Carcinoma
Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate.
Carcinoma
Expression of the cystic fibrosis transmembrane conductance regulator gene can be regulated by protein kinase C.
Carcinoma
Expression patterns of protein kinase C isoenzymes are characteristically modulated in chronic pancreatitis and pancreatic cancer.
Carcinoma
Gemcitabine plus enzastaurin or single-agent gemcitabine in locally advanced or metastatic pancreatic cancer: Results of a Phase II, randomized, noncomparative study.
Carcinoma
Gene therapy through signal transduction pathways and angiogenic growth factors as therapeutic targets in breast cancer.
Carcinoma
Genetic deletion of TNF? inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKC? transgenic mice via inhibition of cell survival signals.
Carcinoma
Genetic events responsible for colorectal tumorigenesis: achievements and challenges.
Carcinoma
GLI activation by atypical protein kinase C ?/? regulates the growth of basal cell carcinomas.
Carcinoma
Growth inhibition of transforming growth factor beta on human gastric carcinoma cells: receptor and postreceptor signaling.
Carcinoma
H7, an inhibitor of protein kinase C, inhibits tumour cell division in mice bearing ascitic Ehrlich's carcinoma.
Carcinoma
Heterogeneity of cellular proliferation within transitional cell carcinoma: correlation of protein kinase C alpha/betaI expression and activity.
Carcinoma
High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells.
Carcinoma
Human pancreatic adenocarcinoma-associated antigens defined by novel murine monoclonal antibodies Pak-1 and Pak-2.
Carcinoma
Identification of protein kinase C as an intermediate in Na,K-ATPase Beta-subunit mediated lamellipodia formation and suppression of cell motility in carcinoma cells.
Carcinoma
Identification of protein kinase C zeta isozyme in hamster pancreas and pancreatic carcinoma cell lines.
Carcinoma
Immunohistochemical evidence for the overexpression of protein kinase C in proliferative diseases of human thyroid.
Carcinoma
Impaired Gap Junction Formation and Intercellular Calcium Signaling in Urinary Bladder Cancer Cells can be Improved by Gö6976.
Carcinoma
Increased transforming growth factor-alpha levels in human colon carcinoma cell lines over-expressing protein kinase C.
Carcinoma
Induction of ANGPTL4 expression in human airway smooth muscle cells by PMA through activation of PKC and MAPK pathways.
Carcinoma
Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G.
Carcinoma
Induction of carcinoma cell migration on vitronectin by NF-kappa B-dependent gene expression.
Carcinoma
Induction of endonuclease G-mediated apopotosis in human oral squamous cell carcinoma cells by protein kinase C inhibitor safingol.
Carcinoma
Induction of the expression of differentiation-related antigens on human colon carcinoma cells by stimulating protein kinase C.
Carcinoma
Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression.
Carcinoma
Inhibition of invasion of invasive human bladder carcinoma cells by protein kinase C inhibitor staurosporine.
Carcinoma
Inhibition of potentially anti-apoptotic proteins by antisense protein kinase C-alpha (Isis 3521) and antisense bcl-2 (G3139) phosphorothioate oligodeoxynucleotides: relationship to the decreased viability of T24 bladder and PC3 prostate cancer cells.
Carcinoma
Inhibition of protein kinase C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters.
Carcinoma
Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.
Carcinoma
Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma.
Carcinoma
Integrin signaling and cell spreading mediated by phorbol 12-myristate 13-acetate treatment.
Carcinoma
Interaction of MUC1 with beta-catenin modulates the Wnt target gene cyclinD1 in H. pylori-induced gastric cancer.
Carcinoma
Interaction of P-glycoprotein with protein kinase C in human multidrug resistant carcinoma cells.
Carcinoma
Intracellular mRNA cleavage induced through activation of RNase P by nuclease-resistant external guide sequences.
Carcinoma
Involvement of protein kinase C and an elastase-like enzyme in the processing of transforming growth factor-alpha in human colon carcinoma cell lines.
Carcinoma
Involvement of protein kinase C in the mechanism of action of Escherichia coli heat-stable enterotoxin (STa) in a human colonic carcinoma cell line, COLO-205.
Carcinoma
Involvement of protein kinase C in the regulation of glycolipid sulfotransferase activity levels in renal cell carcinoma cells.
Carcinoma
Involvement of protein kinase C in the transcriptional regulation of ornithine decarboxylase gene expression by 12-O-tetradecanoylphorbol-13-acetate in T24 human bladder carcinoma cells.
Carcinoma
Involvement of protein kinase C in translocation of desmoplakins from cytosol to plasma membrane during desmosome formation in human squamous cell carcinoma cells grown in low to normal calcium concentration.
Carcinoma
Isolation of cDNAs encoding a substrate for protein kinase C: nucleotide sequence and chromosomal mapping of the gene for a human 80K protein.
Carcinoma
Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.
Carcinoma
Laminin regulates a tumor cell chemotaxis receptor through the laminin-binding integrin subunit alpha 6.
Carcinoma
Loss of protein kinase C delta gene expression in human squamous cell carcinomas: a laser capture microdissection study.
Carcinoma
Loss of protein kinase Calpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma.
Carcinoma
Matrix metalloproteinase 2 and matrix metalloproteinase 9 expression in human oral squamous cell carcinoma and the effect of protein kinase C inhibitors: preliminary observations.
Carcinoma
Membrane-bound protein kinase C modulates receptor affinity and chemotactic responsiveness of Lewis lung carcinoma sublines to an elastin-derived peptide.
Carcinoma
Meta-analysis of oncogenic protein kinase Ciota signaling in lung adenocarcinoma.
Carcinoma
miR-24-3p Suppresses Malignant Behavior of Lacrimal Adenoid Cystic Carcinoma by Targeting PRKCH to Regulate p53/p21 Pathway.
Carcinoma
Modulation of chemosensitivity in human colon carcinoma cells by downregulating protein kinase C alpha expression.
Carcinoma
Modulation of multidrug resistance in human ovarian cancer cell lines by inhibition of P-glycoprotein 170 and PKC isoenzymes with antisense oligonucleotides.
Carcinoma
Modulation of Pancreatic Tumor Potential by Overexpression of Protein Kinase C ?1.
Carcinoma
Multiphoton-FLIM quantification of the EGFP-mRFP1 FRET pair for localization of membrane receptor-kinase interactions.
Carcinoma
Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivo.
Carcinoma
Negative regulation of atrial natriuretic factor receptor coupled membrane guanylate cyclase by phorbol ester. Potential protein kinase C regulation of cyclic GMP signal in isolated adrenocortical carcinoma cells of rat.
Carcinoma
Network Analysis of the Focal Adhesion to Invadopodia Transition Identifies a PI3K-PKC? Invasive Signaling Axis.
Carcinoma
Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon.
Carcinoma
Overexpression of protein kinase C-alpha and -beta isozymes by stromal dendritic cells in basal and squamous cell carcinoma.
Carcinoma
Overexpression of protein kinase C-{epsilon} in the mouse epidermis leads to a spontaneous myeloproliferative-like disease.
Carcinoma
Overexpression of protein kinase Calpha mRNA may be an independent prognostic marker for gastric carcinoma.
Carcinoma
Pak-1 expression increases with progression of colorectal carcinomas to metastasis.
Carcinoma
PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism.
Carcinoma
Patterns of protein kinase C isoenzyme expression in transitional cell carcinoma of bladder. Relation to degree of malignancy.
Carcinoma
Phase II Study of Paclitaxel Plus the Protein Kinase C Inhibitor Bryostatin-1 in Advanced Pancreatic Carcinoma.
Carcinoma
Phenylamino-pyrimidine (PAP) derivatives: a new class of potent and selective inhibitors of protein kinase C (PKC).
Carcinoma
Phorbol esters enhance the cyclic GMP response of T84 cells to the heat-stable enterotoxin of Escherichia coli (STa).
Carcinoma
Phorbol esters rapidly attenuate glutamine uptake and growth in human colon carcinoma cells.
Carcinoma
Phosphatidylcholine could be the source of 1,2-DAG which activates protein kinase C in EGF-stimulated colon carcinoma cells (HT29).
Carcinoma
Phosphatidylcholine-specific phospholipase C, but not phospholipase D, is involved in pemphigus IgG-induced signal transduction.
Carcinoma
PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer.
Carcinoma
PKC iota promotes cellular proliferation by accelerated G1/S transition via interaction with CDK7 in esophageal squamous cell carcinoma.
Carcinoma
PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells.
Carcinoma
PKC? inhibits isolation and stemness of side population cells via the suppression of ABCB1 transporter and PI3K/Akt, MAPK/ERK signaling in renal cell carcinoma cell line 769P.
Carcinoma
PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1.
Carcinoma
Potentiation of glucocorticoid-mediated induction of the mouse mammary tumor virus promoter in mammary carcinoma cells by activation of protein kinase C.
Carcinoma
Pro-transforming growth factor-alpha processing in human colon carcinoma cells: role of protein kinase C.
Carcinoma
Properties of classic protein kinase C in human small cell lung carcinoma NCI-H345 cells.
Carcinoma
Protein Kinase C ? , Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells.
Carcinoma
Protein kinase C ? regulates nuclear pri-microRNA 15a release as part of endothelin signaling.
Carcinoma
Protein kinase C agonist and antagonist effects in normal human epidermal keratinocytes.
Carcinoma
Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells.
Carcinoma
Protein kinase C and cAMP mediated regulation of taurine transport in human colon carcinoma cell lines (HT-29 & Caco-2).
Carcinoma
Protein kinase C and casein kinase II activities in two human colon carcinoma cell lines, HT-29 and CaCo-2: possible correlation with differentiation.
Carcinoma
Protein kinase C and limited substrates for tyrosine kinase are involved in epidermal growth factor (EGF)-dependent growth of a human squamous cell carcinoma cell variant.
Carcinoma
Protein kinase C beta 1 and protein kinase C beta 2 activate p57 mitogen-activated protein kinase and block differentiation in colon carcinoma cells.
Carcinoma
Protein kinase C delta negatively modulates canonical wnt pathway and cell proliferation in colon tumor cell lines.
Carcinoma
Protein kinase C delta overexpressing transgenic mice are resistant to chemically but not to UV radiation-induced development of squamous cell carcinomas: a possible link to specific cytokines and cyclooxygenase-2.
Carcinoma
Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling.
Carcinoma
Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas.
Carcinoma
Protein kinase C epsilon mediates the induction of P-glycoprotein in LNCaP prostate carcinoma cells.
Carcinoma
Protein kinase C epsilon signals ultraviolet light-induced cutaneous damage and development of squamous cell carcinoma possibly through Induction of specific cytokines in a paracrine mechanism.
Carcinoma
Protein kinase C epsilon, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3.
Carcinoma
Protein kinase C eta is associated with progression of renal cell carcinoma (RCC).
Carcinoma
Protein kinase C in human renal cell carcinomas: role in invasion and differential isoenzyme expression.
Carcinoma
Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell.
Carcinoma
Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis.
Carcinoma
Protein kinase C isoforms in the chemopreventive effects of a novel vitamin D3 analogue in rat colonic tumorigenesis.
Carcinoma
Protein kinase C mediated anti-proliferative glucocorticoid-sphinganine synergism in cultured Pollard III prostate tumor cells.
Carcinoma
Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells.
Carcinoma
Protein kinase C signalling pathway is involved in the regulation of vascular endothelial growth factor expression in human bladder transitional carcinoma cells.
Carcinoma
Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.
Carcinoma
Protein kinase C-alpha is expressed and activated during the development of renal cell carcinoma.
Carcinoma
Protein kinase C-dependent in vivo phosphorylation of prourokinase leads to the formation of a receptor competitive antagonist.
Carcinoma
Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma.
Carcinoma
Protein kinase Calpha controls the adhesion but not the antiproliferative response of human colon carcinoma cells to transforming growth factor beta1: identification of two distinct branches of post-protein kinase Calpha adhesion signal pathway.
Carcinoma
Protein kinase Calpha determines HER2 fate in breast carcinoma cells with HER2 protein overexpression without gene amplification.
Carcinoma
Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer.
Carcinoma
Protein kinase Cepsilon interacts with Stat3 and regulates its activation that is essential for the development of skin cancer.
Carcinoma
Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.
Carcinoma
Protein Kinase Cvarepsilon Inhibits UVR-Induced Expression of FADD, an Adaptor Protein, Linked to both Fas- and TNFR1-Mediated Apoptosis.
Carcinoma
Protein phosphorylation substrates in normal and neoplastic squamous epithelia of the human upper aero-digestive tract.
Carcinoma
Quantitative kinetic study of the actin-bundling protein L-plastin and of its impact on actin turn-over.
Carcinoma
Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells.
Carcinoma
Reduced daunomycin accumulation in drug-sensitive and multidrug-resistant human carcinoma KB cells following phorbol ester treatment: a potential role for protein kinase C in reducing drug influx.
Carcinoma
Regulation of integrin-mediated adhesion by muscarinic acetylcholine receptors and protein kinase C in small cell lung carcinoma.
Carcinoma
Regulation of phosphoinositide hydrolysis induced by histamine and guanine nucleotides in human HeLa carcinoma cells. Calcium and pH dependence and inhibitory role of protein kinase C.
Carcinoma
Regulation of taurine transport in human colon carcinoma cell lines (HT-29 and Caco-2) by protein kinase C.
Carcinoma
Reorganization of cytoskeletal proteins by Escherichia coli heat-stable enterotoxin (STa)-mediated signaling cascade.
Carcinoma
Requirement of protein kinase C micro activation and calpain-mediated proteolysis for arachidonic acid-stimulated adhesion of MDA-MB-435 human mammary carcinoma cells to collagen type IV.
Carcinoma
Resveratrol affects protein kinase C activity and promotes apoptosis in human colon carcinoma cells.
Carcinoma
Role of insulin receptor substrates and protein kinase C-zeta in vascular permeability factor/vascular endothelial growth factor expression in pancreatic cancer cells.
Carcinoma
Role of protein kinase C alpha in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinoma.
Carcinoma
Role of protein kinase C alpha in the induction of carcinoembryonic antigen by transforming growth factor beta 1.
Carcinoma
Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells.
Carcinoma
Role of protein kinase C in transforming growth factor-beta 1 induction of carcinoembryonic antigen in human colon carcinoma cells.
Carcinoma
Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C.
Carcinoma
Stimulation of CEACAM1 expression by 12-O-tetradecanoylphorbol-13-acetate (TPA) and calcium ionophore A23187 in endometrial carcinoma cells.
Carcinoma
Suppression of growth of H-69 small cell lung carcinoma by antagonists of growth hormone releasing hormone and bombesin is associated with an inhibition of protein kinase C signaling.
Carcinoma
Synergistic effect of Sorafenib and Sunitinib with Enzastaurin, a selective protein kinase C inhibitor in renal cell carcinoma cell lines.
Carcinoma
Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma.
Carcinoma
Temozolomide reduces the metastatic potential of Lewis lung carcinoma (3LL) in mice: role of alpha-6 integrin phosphorylation.
Carcinoma
The 27,000 daltons stress proteins are phosphorylated by protein kinase C during the tumor promoter-mediated growth inhibition of human mammary carcinoma cells.
Carcinoma
The effect of fetal calf serum on growth arrest caused by activators of protein kinase C.
Carcinoma
The effect of protein kinase C inhibitors on invasion of human ovary cancer cells.
Carcinoma
The enterocyte-like differentiation of the Caco-2 tumor cell line strongly correlates with responsiveness to cAMP and activation of kinase A pathway.
Carcinoma
The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma.
Carcinoma
The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas.
Carcinoma
The protein kinase C (PKC) substrate GAP-43 is already expressed in neural precursor cells, colocalizes with PKCeta and binds calmodulin.
Carcinoma
The protein kinase C inhibitor, CGP 41 251, reverses decreased daunomycin uptake in a human drug-resistant ovarian carcinoma cell line.
Carcinoma
The role of protein kinase C and the phosphatidylinositol cycle in multidrug resistance in human ovarian cancer cells.
Carcinoma
The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity.
Carcinoma
The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways.
Carcinoma
Time to disease progression to evaluate a novel protein kinase C inhibitor, UCN-01, in renal cell carcinoma.
Carcinoma
Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells.
Carcinoma
Toward a more complete recognition of immunoreactive antigens in squamous cell lung carcinoma.
Carcinoma
Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.
Carcinoma
Transient translocation of hemidesmosomal bullous pemphigoid antigen 1 from cytosol to membrane fractions by 12-O-tetradecanoylphorbol-13-acetate treatment and Ca2+-switch in a human carcinoma cell line.
Carcinoma
Tumor grade-dependent alterations in the protein kinase C isoform pattern in urinary bladder carcinomas.
Carcinoma
Ultraviolet radiation and 12-O-tetradecanoylphorbol-13-acetate-induced interaction of mouse epidermal protein kinase C ? with Stat3 involve integration with Erk1/2.
Carcinoma
Uneven distribution of protein kinase C-alpha and -beta isozymes in human sarcomas and carcinomas.
Carcinoma
[Cell membrane phospholipid variation and protein kinase C expression effects on hepatic metastasis of large intestinal carcinoma]
Carcinoma
[Expression and significance of telomerase reverse transcriptase and its regulators in non-small cell lung carcinoma]
Carcinoma
[Expressions of five protein kinase C isoforms in salivary adenoid cystic carcinoma]
Carcinoma
[Growth suppression of squamous cell carcinoma cell lines by PKCs--possible application to gene therapy]
Carcinoma
[Role of protein kinase C-delta in hyperthermia-induced apoptosis in tongue squamous cell carcinoma Tca8113 cells].
Carcinoma
[The effect of protein kinase C on the invasive behavior of human salivary adenoid cystic carcinoma in vitro]
Carcinoma
[The role of protein kinase C alpha in recurrence of superficial bladder carcinoma]
Carcinoma
[The variation of intracellular distribution and translocation of the protein kinase C alpha among human lung cancer cell line with different metastasis potential.]
Carcinoma, Adenoid Cystic
DOG1 Utility in diagnosing gastrointestinal stromal tumors on fine-needle aspiration.
Carcinoma, Adenoid Cystic
miR-24-3p Suppresses Malignant Behavior of Lacrimal Adenoid Cystic Carcinoma by Targeting PRKCH to Regulate p53/p21 Pathway.
Carcinoma, Adenoid Cystic
[Expressions of five protein kinase C isoforms in salivary adenoid cystic carcinoma]
Carcinoma, Adenoid Cystic
[The effect of protein kinase C on the invasive behavior of human salivary adenoid cystic carcinoma in vitro]
Carcinoma, Basal Cell
Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases.
Carcinoma, Basal Cell
GLI activation by atypical protein kinase C ?/? regulates the growth of basal cell carcinomas.
Carcinoma, Basal Cell
Loss of protein kinase Calpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma.
Carcinoma, Basal Cell
Overexpression of protein kinase C-alpha and -beta isozymes by stromal dendritic cells in basal and squamous cell carcinoma.
Carcinoma, Ductal
Expression patterns of protein kinase C isoenzymes are characteristically modulated in chronic pancreatitis and pancreatic cancer.
Carcinoma, Ductal
PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer.
Carcinoma, Ductal
PKC?/? signaling promotes triple-negative breast cancer growth and metastasis.
Carcinoma, Ductal
Protein kinase C alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma.
Carcinoma, Ehrlich Tumor
Activation of protein kinase C during cell volume regulation in Ehrlich mouse ascites tumor cells.
Carcinoma, Ehrlich Tumor
Effect of hyperthermia and protein kinase C inhibitors on DNA synthesis and cell proliferation on Ehrlich ascites tumour cells in vitro.
Carcinoma, Ehrlich Tumor
Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.
Carcinoma, Ehrlich Tumor
Enhancement of spermidine/spermine N1-acetyltransferase activity by treatment with lithium chloride in Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Identification of phosphorylation sites on murine nuclear lamin C by RP-HPLC and microsequencing.
Carcinoma, Ehrlich Tumor
Na+, K+, Cl- cotransport and its regulation in Ehrlich ascites tumor cells. Ca2+/calmodulin and protein kinase C dependent pathways.
Carcinoma, Ehrlich Tumor
Phosphorylation is involved in the regulation of the taurine influx via the beta-system in Ehrlich ascites tumor cells.
Carcinoma, Embryonal
A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.
Carcinoma, Embryonal
Distinct functions of protein kinase Calpha and protein kinase Cbeta during retinoic acid-induced differentiation of F9 cells.
Carcinoma, Embryonal
Protein kinase C and phorbol ester receptor expression related to growth and differentiation of nullipotent and pluripotent embryonal carcinoma cells.
Carcinoma, Embryonal
The SV40 TC-II(kappa B) and the related H-2Kb enhansons exhibit different cell type specific and inducible proto-enhancer activities, but the SV40 core sequence and the AP-2 binding site have no enhanson properties.
Carcinoma, Endometrioid
Analysis of protein kinase C delta (PKC delta) expression in endometrial tumors.
Carcinoma, Endometrioid
Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis.
Carcinoma, Hepatocellular
"Expression of Protein Kinase C?and the MZF-1 and Elk-1 Transcription Factors in Human Breast Cancer Cells".
Carcinoma, Hepatocellular
(-)-Epigallocatechin-3-gallate stimulates both AMP-activated protein kinase and nuclear factor-kappa B signaling pathways.
Carcinoma, Hepatocellular
Activation of protein kinase C alpha is required for TPA-triggered ERK (MAPK) signaling and growth inhibition of human hepatoma cell HepG2.
Carcinoma, Hepatocellular
Activation of protein kinase C in human hepatocellular carcinoma (HEP3B) cells increases erythropoietin production.
Carcinoma, Hepatocellular
Activation of protein kinase C stimulates the tyrosine phosphorylation and guanosine triphosphatase-activating protein association of p60 in rat hepatoma cells.
Carcinoma, Hepatocellular
Activation of protein kinase Calpha couples cell volume to membrane Cl- permeability in HTC hepatoma and Mz-ChA-1 cholangiocarcinoma cells.
Carcinoma, Hepatocellular
Alteration in the expression of protein kinase C isoforms in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
An insight into the mechanism of cytotoxicity of ricin to hepatoma cell: roles of Bcl-2 family proteins, caspases, Ca(2+)-dependent proteases and protein kinase C.
Carcinoma, Hepatocellular
Analysing the expression of protein kinase C eta in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Anti-invasive activity of ?-tocopherol against hepatoma cells in culture via protein kinase C inhibition.
Carcinoma, Hepatocellular
Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line.
Carcinoma, Hepatocellular
Antisense oligonucleotide Elk-1 suppresses the tumorigenicity of human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Assessment of the metastatic ability of rat hepatoma cells in chick embryos by the polymerase-chain reaction.
Carcinoma, Hepatocellular
beta-estradiol stimulation of DNA synthesis requires different PKC isoforms in HepG2 and MCF7 cells.
Carcinoma, Hepatocellular
Both type I and type II interferons down-regulate human tumor necrosis factor receptors in human hepatocellular carcinoma cell line Hep G2. Role of protein kinase C.
Carcinoma, Hepatocellular
Changes in mRNA levels of intracellular fatty acid metabolism regulators in human hepatoma HepG2 cells following their treatment with non-esterified fatty acids and dehydroepiandrosterone.
Carcinoma, Hepatocellular
Characteristic changes in protein-kinase-C activity and isoforms in ah66 cells during the acquisition of multidrug-resistant phenotype.
Carcinoma, Hepatocellular
Critical role of diacylglycerol- and phospholipid-regulated protein kinase C epsilon in induction of low-density lipoprotein receptor transcription in response to depletion of cholesterol.
Carcinoma, Hepatocellular
Different induction of two plasminogen activator inhibitor 1 mRNA species by phorbol ester in human hepatoma cells.
Carcinoma, Hepatocellular
Differential effects of dietary fatty acids on the regulation of CYP2E1 and protein kinase C in human hepatoma HepG2 cells.
Carcinoma, Hepatocellular
Differential effects of phorbol ester on growth and protein kinase C isoenzyme regulation in human hepatoma Hep3B cells.
Carcinoma, Hepatocellular
Differential expression of five protein kinase C isoenzymes in FAO and HepG2 hepatoma cell lines compared with normal rat hepatocytes.
Carcinoma, Hepatocellular
Differential pathways of insulin action upon the hepatitis B surface antigen gene expression and cell proliferation in human hepatoma cells.
Carcinoma, Hepatocellular
Differential phorbol ester growth modulation and protein-kinase-C isoenzyme expression in rat hepatoma-cells vs non neoplastic rat hepatocytes.
Carcinoma, Hepatocellular
Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1.
Carcinoma, Hepatocellular
Distinct nongenomic signal transduction pathways controlled by 17beta-estradiol regulate DNA synthesis and cyclin D(1) gene transcription in HepG2 cells.
Carcinoma, Hepatocellular
Distinct signaling pathways mediate phorbol-ester-induced and cytokine-induced inhibition of erythropoietin gene expression.
Carcinoma, Hepatocellular
Divergent effects of phorbol esters and insulin on insulin-like growth factor binding protein-1 (IGFBP-1) production and mRNA in rat H4IIE hepatoma cells.
Carcinoma, Hepatocellular
Down-regulation of particulate protein kinase Cepsilon and up-regulation of nuclear activator protein-1 DNA binding in liver following in vivo exposure of B6C3F1 male mice to heptachlor epoxide.
Carcinoma, Hepatocellular
Down-regulation of S1P1 receptor surface expression by protein kinase C inhibition.
Carcinoma, Hepatocellular
Doxorubicin enhances transient expression of p-glycoprotein and modulates activity and isoform expression of protein-kinase-C in ah66 rat hepatoma-cells.
Carcinoma, Hepatocellular
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Carcinoma, Hepatocellular
E2F1 transactivates IQGAP3 and promotes proliferation of hepatocellular carcinoma cells through IQGAP3-mediated PKC-alpha activation.
Carcinoma, Hepatocellular
Effect of protein kinase C activation and depletion on insulin stimulation of glycogen synthesis in cultured hepatoma cells.
Carcinoma, Hepatocellular
Effects of antisense oligonucleotides of PKC-alpha on proliferation and apoptosis of HepG2 in vitro.
Carcinoma, Hepatocellular
Epsilon PKC acts like a marker of progressive malignancy in rat liver, but fails to enhance tumorigenesis in rat hepatoma cells in culture.
Carcinoma, Hepatocellular
Evidence for a role of protein kinase C in the activation of the pyruvate dehydrogenase complex by insulin in Zajdela hepatoma cells.
Carcinoma, Hepatocellular
Evidence for diverse roles of protein kinase-C in the inhibition of gene expression by insulin: the tyrosine aminotransferase, albumin, and phosphoenolpyruvate carboxykinase genes.
Carcinoma, Hepatocellular
Expression of calcium-binding protein regucalcin mRNA in the cloned rat hepatoma cells (H4-II-E) is stimulated through Ca2+ signaling factors: involvement of protein kinase C.
Carcinoma, Hepatocellular
Expression of protein kinase C alpha in biopsies and surgical specimens of human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Expression of Protein Kinase C Family in Human Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Expression of protein kinase C? and the MZF-1 and elk-1 transcription factors in human bladder transitional cell carcinoma cells.
Carcinoma, Hepatocellular
FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling.
Carcinoma, Hepatocellular
Glucocorticoid regulation of phospholipid turnover and protein kinase C activity in mouse hepatoma 22 cells.
Carcinoma, Hepatocellular
Hepatoma-targeted gene delivery using a tumor cell-specific gene regulation system combined with a human liver cell-specific bionanocapsule.
Carcinoma, Hepatocellular
Identification of a protein kinase C (PKC) activator, daphnoretin, that suppresses hepatitis B virus gene expression in human hepatoma cells.
Carcinoma, Hepatocellular
Immunochemical localization of protein kinase Calpha in the biopsies of human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Inhibition by protein kinase C inhibitor of expression of leukocyte function-associated antigen-1 molecules in rat hepatoma AH66F cells.
Carcinoma, Hepatocellular
Inhibition of erythropoietin production by phorbol ester is associated with down-regulation of protein kinase C-alpha isoenzyme in hepatoma cells.
Carcinoma, Hepatocellular
Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo.
Carcinoma, Hepatocellular
Inhibition of the membrane translocation and activation of protein kinase C, and potentiation of doxorubicin-induced apoptosis of hepatocellular carcinoma cells by tamoxifen.
Carcinoma, Hepatocellular
Inhibitory effect of hepatocyte growth factor against FaO hepatocellular carcinoma cells may be associated with changes of intracellular signalling pathways mediated by protein kinase C.
Carcinoma, Hepatocellular
Interaction of insulin, glucocorticoids, and protein kinase C in the regulation of insulin-like growth factor-binding protein-1 production by H4IIE rat hepatoma cells.
Carcinoma, Hepatocellular
Involvement of down-regulation-resistant protein kinase C in teleocidin inhibition of cell proliferation and calcium mobilization induced by epidermal growth factor and vasopressin in human hepatoma cells.
Carcinoma, Hepatocellular
Involvement of PKC betaII in anti-proliferating action of a new antitumor compound gnidimacrin.
Carcinoma, Hepatocellular
Involvement of protein kinase C beta-extracellular signal-regulating kinase 1/2/p38 mitogen-activated protein kinase-heat shock protein 27 activation in hepatocellular carcinoma cell motility and invasion.
Carcinoma, Hepatocellular
Involvement of protein kinase C in the regulation of ornithine decarboxylase mRNA by phorbol esters in rat hepatoma cells.
Carcinoma, Hepatocellular
Involvement of the alpha isoenzyme of protein kinase C in the growth inhibition induced by phorbol esters in MH1C1 hepatoma cells.
Carcinoma, Hepatocellular
Kinase gene expression and subcellular protein expression pattern of protein kinase C isoforms in curcumin-treated human hepatocellular carcinoma Hep 3B cells.
Carcinoma, Hepatocellular
Lead may affect glucocorticoid signal transduction in cultured hepatoma cells through inhibition of protein kinase C.
Carcinoma, Hepatocellular
Leukocyte function-associated antigen 1-dependent adhesion of rat hepatoma AH66F cells and inhibition by protein kinase C inhibitors.
Carcinoma, Hepatocellular
Metabolic stress opens K+ channels in hepatoma cells through a Ca2+- and protein kinase calpha-dependent mechanism.
Carcinoma, Hepatocellular
MZF-1/Elk-1 Complex Binds to Protein Kinase C? Promoter and Is Involved in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Overexpression of protein kinase C alpha mRNA in human hepatocellular carcinoma: a potential marker of disease prognosis.
Carcinoma, Hepatocellular
p38 mitogen-activated protein kinase pathway is involved in protein kinase Calpha-regulated invasion in human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2).
Carcinoma, Hepatocellular
PKC? mediates mitochondrial ROS generation and oxidation of HSP60 to relieve RKIP inhibition on MAPK pathway for HCC progression.
Carcinoma, Hepatocellular
PKCalpha mediated induction of miR-101 in human hepatoma HepG2 cells.
Carcinoma, Hepatocellular
PKCtheta is a key player in the development of insulin resistance.
Carcinoma, Hepatocellular
Protein kinase C alpha location and the expression of phospho-MEK and MDR1 in hepatitis virus-related hepatocellular carcinoma biopsies.
Carcinoma, Hepatocellular
Protein kinase C alpha protein expression is necessary for sustained erythropoietin production in human hepatocellular carcinoma (Hep3B) cells exposed to hypoxia.
Carcinoma, Hepatocellular
Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2.
Carcinoma, Hepatocellular
Protein kinase C bound to the Golgi apparatus supports the formation of constitutive transport vesicles.
Carcinoma, Hepatocellular
Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Protein kinase C inhibitor, H-7 suppresses the growth activity of hepatoma-derived growth factor.
Carcinoma, Hepatocellular
Protein kinase C regulates nutrient uptake and growth in hepatoma cells.
Carcinoma, Hepatocellular
Protein kinase C-mediated tyrosine phosphorylation of paxillin and focal adhesion kinase requires cytoskeletal integrity and is uncoupled to mitogen-activated protein kinase activation in human hepatoma cells.
Carcinoma, Hepatocellular
Protein kinase-C activation increases the quantity and poly(A) tail length of corticotropin-releasing hormone messenger RNA in NPLC cells.
Carcinoma, Hepatocellular
Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2.
Carcinoma, Hepatocellular
Reactive oxygen species-mediated PKC and integrin signaling promotes tumor progression of human hepatoma HepG2.
Carcinoma, Hepatocellular
Receptor for activated protein kinase C: requirement for efficient microRNA function and reduced expression in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Reduction of PKC alpha decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinoma.
Carcinoma, Hepatocellular
Reverse relationship between malignancy and cyclic AMP-dependent protein kinase activity in Yoshida rat ascites hepatomas.
Carcinoma, Hepatocellular
Role of c-Jun and proximal phorbol 12-myristate-13-acetate-(PMA)-responsive elements in the regulation of basal and PMA-stimulated plasminogen-activator inhibitor-1 gene expression in HepG2.
Carcinoma, Hepatocellular
Role of PKCbeta in hepatocellular carcinoma cells migration and invasion in vitro: a potential therapeutic target.
Carcinoma, Hepatocellular
Role of protein kinase C in insulin's regulation of c-fos transcription.
Carcinoma, Hepatocellular
Role of tyrosine kinase signaling in estrogen-induced LDL receptor gene expression in HepG2 cells.
Carcinoma, Hepatocellular
Study on the mechanism of epidermal growth factor-induced proliferation of hepatoma cells.
Carcinoma, Hepatocellular
Suppression of cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells by 12-O-tetradecanoylphorbol-13-acetate and inhibitors of protein kinase C.
Carcinoma, Hepatocellular
Suppression of tumorigenicity of human hepatocellular carcinoma cells by antisense oligonucleotide MZF-1.
Carcinoma, Hepatocellular
Tauroursodeoxycholic acid mobilizes alpha-PKC after uptake in human HepG2 hepatoma cells.
Carcinoma, Hepatocellular
The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway.
Carcinoma, Hepatocellular
The induction of the human hepatic CYP2E1 gene by interleukin 4 is transcriptional and regulated by protein kinase C.
Carcinoma, Hepatocellular
The influence of extracellular calcium on the distribution of protein kinase C in non-neoplastic and neoplastic rat liver cells.
Carcinoma, Hepatocellular
The inhibition of phosphoenolpyruvate carboxykinase (guanosine triphosphate) gene expression by insulin is not mediated by protein kinase C.
Carcinoma, Hepatocellular
Transcriptional regulation of a rat hepatoma gene by insulin and protein kinase-C.
Carcinoma, Hepatocellular
Translocation of PKC delta by insulin in a rat hepatoma cell line.
Carcinoma, Hepatocellular
Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest.
Carcinoma, Hepatocellular
Tyrosine kinase inhibitors potentiate the induction of low density lipoprotein receptor gene expression by hepatocyte growth factor.
Carcinoma, Hepatocellular
Vacuole formation and cytokeratin rearrangement of hepatoma cells induced by teleocidin are not associated with down-regulation of protein kinase C.
Carcinoma, Hepatocellular
[Comparative study of protein kinase C in the normal rat liver and in Zajdela's hepatoma. I. Electrophoretic analysis]
Carcinoma, Hepatocellular
[Regulation of glucose metabolism by insulin: dual role of protein kinase C]
Carcinoma, Hepatocellular
[Regulation of the phospholipid turnover rate and protein kinase C activity as a necessary stage in the realization of the growth-inhibiting effect of dexamethasone on hepatoma 22 cells]
Carcinoma, Intraductal, Noninfiltrating
Protein kinase C alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma.
Carcinoma, Islet Cell
Human pancreatic adenocarcinoma-associated antigens defined by novel murine monoclonal antibodies Pak-1 and Pak-2.
Carcinoma, Lewis Lung
Comparison of the effects of auranofin and retinoic acid on plasminogen activator activity of peritoneal macrophages and Lewis lung carcinoma cells.
Carcinoma, Lewis Lung
Laminin regulates a tumor cell chemotaxis receptor through the laminin-binding integrin subunit alpha 6.
Carcinoma, Lewis Lung
Membrane-bound protein kinase C modulates receptor affinity and chemotactic responsiveness of Lewis lung carcinoma sublines to an elastin-derived peptide.
Carcinoma, Lewis Lung
Temozolomide reduces the metastatic potential of Lewis lung carcinoma (3LL) in mice: role of alpha-6 integrin phosphorylation.
Carcinoma, Merkel Cell
Activation of Protein Kinase C ? in Merkel Cell Polyomavirus-Induced Merkel Cell Carcinoma.
Carcinoma, Non-Small-Cell Lung
A phase I/II study of LY900003, an antisense inhibitor of protein kinase C-alpha, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Activation of protein kinase C by phorbol 12-myristate 13-acetate suppresses the growth of lung cancer cells through KLF6 induction.
Carcinoma, Non-Small-Cell Lung
Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance.
Carcinoma, Non-Small-Cell Lung
Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity.
Carcinoma, Non-Small-Cell Lung
Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ciota.
Carcinoma, Non-Small-Cell Lung
Cyclooxygenase-2 up-regulates vascular endothelial growth factor via a protein kinase C pathway in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Inhibition of novel protein kinase C-epsilon augments TRAIL-induced cell death in A549 lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Inhibition of protein kinase C ?/?II and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells.
Carcinoma, Non-Small-Cell Lung
l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters.
Carcinoma, Non-Small-Cell Lung
Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon.
Carcinoma, Non-Small-Cell Lung
Ophiopogon Saponin C1 Inhibits Lung Tumors by Stabilizing Endothelium Permeability via Inhibition of PKC?.
Carcinoma, Non-Small-Cell Lung
Phase II study of PKC-alpha antisense oligonucleotide aprinocarsen in combination with gemcitabine and carboplatin in patients with advanced non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
PKC? regulates integrin ?V?3 expression and transformed growth of K-ras dependent lung cancer cells.
Carcinoma, Non-Small-Cell Lung
PKC? regulates Rho GTPases and actin cytoskeleton reorganization in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Protein Kinase C as a Therapeutic Target in Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner.
Carcinoma, Non-Small-Cell Lung
Protein Kinase C Isozymes Associated With Relapse Free Survival in Non-Small Cell Lung Cancer Patients.
Carcinoma, Non-Small-Cell Lung
Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway.
Carcinoma, Non-Small-Cell Lung
Protein kinase Czeta abrogates the proapoptotic function of Bax through phosphorylation.
Carcinoma, Non-Small-Cell Lung
S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Staurosporine increases toxicity of gemcitabine in non-small cell lung cancer cells: role of protein kinase C, deoxycytidine kinase and ribonucleotide reductase.
Carcinoma, Non-Small-Cell Lung
Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase.
Carcinoma, Non-Small-Cell Lung
The oncogenic role of PKCiota gene amplification and overexpression in Chinese non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
The protein kinase C (PKC) inhibitors combined with chemotherapy in the treatment of advanced non-small cell lung cancer: meta-analysis of randomized controlled trials.
Carcinoma, Non-Small-Cell Lung
Transactivation of hsp70-1/2 in geldanamycin-treated human non-small cell lung cancer H460 cells: involvement of intracellular calcium and protein kinase C.
Carcinoma, Non-Small-Cell Lung
[A study on the relationship between the expression of protein kinase C ?II and apoptosis in patients with non-small cell lung cancer.]
Carcinoma, Non-Small-Cell Lung
[Effects of a protein kinase C inhibitor combined with cisplatin on non-small cell lung cancer]
Carcinoma, Non-Small-Cell Lung
[Expression and significance of telomerase reverse transcriptase and its regulators in non-small cell lung carcinoma]
Carcinoma, Non-Small-Cell Lung
[Protein kinase C inhibitor and treatment of non-small cell lung cancer.]
Carcinoma, Non-Small-Cell Lung
[The clinical signifcance of expression of ERCC1 and PkCalpha in non-small cell lung cancer]
Carcinoma, Ovarian Epithelial
Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.
Carcinoma, Ovarian Epithelial
Follicle-stimulating hormone promotes the growth of human epithelial ovarian cancer cells through the protein kinase C-mediated system.
Carcinoma, Pancreatic Ductal
Differentiation of pancreatic ductal carcinoma cells associated with selective expression of protein kinase C isoforms.
Carcinoma, Pancreatic Ductal
Human pancreatic adenocarcinoma-associated antigens defined by novel murine monoclonal antibodies Pak-1 and Pak-2.
Carcinoma, Papillary
Immunohistochemical evidence for the overexpression of protein kinase C in proliferative diseases of human thyroid.
Carcinoma, Papillary
Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.
Carcinoma, Papillary
The natural protein kinase C alpha mutant is present in human thyroid neoplasms.
Carcinoma, Renal Cell
Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta.
Carcinoma, Renal Cell
Expression of protein kinase C in human renal cell carcinoma cells with inherent resistance to doxorubicin.
Carcinoma, Renal Cell
Inhibitory effects of tetradecanoylphorbol acetate and diacylglycerol on erythropoietin production in human renal carcinoma cell cultures.
Carcinoma, Renal Cell
Involvement of protein kinase C in the regulation of glycolipid sulfotransferase activity levels in renal cell carcinoma cells.
Carcinoma, Renal Cell
PKC? inhibits isolation and stemness of side population cells via the suppression of ABCB1 transporter and PI3K/Akt, MAPK/ERK signaling in renal cell carcinoma cell line 769P.
Carcinoma, Renal Cell
Protein kinase C eta is associated with progression of renal cell carcinoma (RCC).
Carcinoma, Renal Cell
Protein kinase C in human renal cell carcinomas: role in invasion and differential isoenzyme expression.
Carcinoma, Renal Cell
Protein kinase C-alpha is expressed and activated during the development of renal cell carcinoma.
Carcinoma, Renal Cell
Role of protein kinase C during interferon-gamma- and phorbol ester-stimulated immunocytochemical expression of ICAM-1 in human renal carcinoma cells.
Carcinoma, Renal Cell
Synergistic effect of Sorafenib and Sunitinib with Enzastaurin, a selective protein kinase C inhibitor in renal cell carcinoma cell lines.
Carcinoma, Renal Cell
The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
The serine proteinase thrombin promotes migration of human renal carcinoma cells by a PKA-dependent mechanism.
Carcinoma, Renal Cell
The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways.
Carcinoma, Renal Cell
Time to disease progression to evaluate a novel protein kinase C inhibitor, UCN-01, in renal cell carcinoma.
Carcinoma, Renal Cell
Tumor necrosis factor mediates apoptosis via Ca++/Mg++ dependent endonuclease with protein kinase C as a possible mechanism for cytokine resistance in human renal carcinoma cells.
Carcinoma, Renal Cell
Weekly bryostatin-1 in metastatic renal cell carcinoma: a phase II study.
Carcinoma, Renal Cell
[Mechanism of reversal of multidrug resistance in human renal carcinoma cells by protein kinase C inhibitor]
Carcinoma, Squamous Cell
A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle.
Carcinoma, Squamous Cell
A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells.
Carcinoma, Squamous Cell
Akt, protein kinase C, and mitogen-activated protein kinase phosphorylation status in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Alterations in levels of different protein kinase C isotypes and their influence on behavior of squamous cell carcinoma of the oral cavity: epsilon PKC, a novel prognostic factor for relapse and survival.
Carcinoma, Squamous Cell
Antitumor activity of enzastaurin as radiation sensitizer in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines.
Carcinoma, Squamous Cell
Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells.
Carcinoma, Squamous Cell
Biphasic effects of 12-O-tetradecanoylphorbol-13-acetate on the cell morphology of low calcium-grown human epidermal carcinoma cells: involvement of translocation and down regulation of protein kinase C.
Carcinoma, Squamous Cell
Correlation between cell-cell contact formation and activation of protein kinase C in a human squamous cell carcinoma cell line.
Carcinoma, Squamous Cell
Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases.
Carcinoma, Squamous Cell
Dual bradykinin B2 receptor signalling in A431 human epidermoid carcinoma cells: activation of protein kinase C is counteracted by a GS-mediated stimulation of the cyclic AMP pathway.
Carcinoma, Squamous Cell
Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice.
Carcinoma, Squamous Cell
Ectopic Expression of Protein Kinase C-? Sensitizes Head and Neck Squamous Cell Carcinoma to Diterpene Esters.
Carcinoma, Squamous Cell
Effect of protein kinase C alpha, caspase-3, and survivin on apoptosis of oral cancer cells induced by staurosporine.
Carcinoma, Squamous Cell
Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells.
Carcinoma, Squamous Cell
Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context.
Carcinoma, Squamous Cell
Epidermal growth factor regulates topoisomerase II activity and drug sensitivity in human KB cells.
Carcinoma, Squamous Cell
Expression levels of protein kinase C-alpha in non-small-cell lung cancer.
Carcinoma, Squamous Cell
Genetic deletion of TNF? inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKC? transgenic mice via inhibition of cell survival signals.
Carcinoma, Squamous Cell
Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.
Carcinoma, Squamous Cell
Inhibitory regulation of serum factor(s)-caused ornithine decarboxylase induction by the protein kinase C system in A431 human epidermoid carcinoma cells.
Carcinoma, Squamous Cell
Interphase and M-phase oral KB carcinoma cells are targetted in staurosporine-induced apoptosis.
Carcinoma, Squamous Cell
Involvement of protein kinase C in translocation of desmoplakins from cytosol to plasma membrane during desmosome formation in human squamous cell carcinoma cells grown in low to normal calcium concentration.
Carcinoma, Squamous Cell
Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart.
Carcinoma, Squamous Cell
Loss of protein kinase C delta gene expression in human squamous cell carcinomas: a laser capture microdissection study.
Carcinoma, Squamous Cell
Overexpression of protein kinase C-alpha and -beta isozymes by stromal dendritic cells in basal and squamous cell carcinoma.
Carcinoma, Squamous Cell
Overexpression of protein kinase C-{epsilon} in the mouse epidermis leads to a spontaneous myeloproliferative-like disease.
Carcinoma, Squamous Cell
Phorbol ester binding and protein kinase C activity in normal and transformed human keratinocytes.
Carcinoma, Squamous Cell
Phosphatidylcholine-specific phospholipase C, but not phospholipase D, is involved in pemphigus IgG-induced signal transduction.
Carcinoma, Squamous Cell
Phosphorylation of the EGF receptor from A431 epidermoid carcinoma cells by three distinct types of protein kinase C.
Carcinoma, Squamous Cell
Protein Kinase C ? , Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells.
Carcinoma, Squamous Cell
Protein kinase C agonist and antagonist effects in normal human epidermal keratinocytes.
Carcinoma, Squamous Cell
Protein kinase C and limited substrates for tyrosine kinase are involved in epidermal growth factor (EGF)-dependent growth of a human squamous cell carcinoma cell variant.
Carcinoma, Squamous Cell
Protein kinase C deficiency blocks recovery from agonist-induced desensitization.
Carcinoma, Squamous Cell
Protein kinase C delta overexpressing transgenic mice are resistant to chemically but not to UV radiation-induced development of squamous cell carcinomas: a possible link to specific cytokines and cyclooxygenase-2.
Carcinoma, Squamous Cell
Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas.
Carcinoma, Squamous Cell
Protein kinase C epsilon signals ultraviolet light-induced cutaneous damage and development of squamous cell carcinoma possibly through Induction of specific cytokines in a paracrine mechanism.
Carcinoma, Squamous Cell
Protein kinase C epsilon, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3.
Carcinoma, Squamous Cell
Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.
Carcinoma, Squamous Cell
Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma.
Carcinoma, Squamous Cell
Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer.
Carcinoma, Squamous Cell
Protein kinase Cepsilon interacts with Stat3 and regulates its activation that is essential for the development of skin cancer.
Carcinoma, Squamous Cell
Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.
Carcinoma, Squamous Cell
Protein Kinase Cvarepsilon Inhibits UVR-Induced Expression of FADD, an Adaptor Protein, Linked to both Fas- and TNFR1-Mediated Apoptosis.
Carcinoma, Squamous Cell
Protein phosphorylation substrates in normal and neoplastic squamous epithelia of the human upper aero-digestive tract.
Carcinoma, Squamous Cell
Role of protein kinase C alpha in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinoma.
Carcinoma, Squamous Cell
Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas.
Carcinoma, Squamous Cell
The protein kinase C-related PKC-L(eta) gene product is localized in the cell nucleus.
Carcinoma, Squamous Cell
Transient translocation of hemidesmosomal bullous pemphigoid antigen 1 from cytosol to membrane fractions by 12-O-tetradecanoylphorbol-13-acetate treatment and Ca2+-switch in a human carcinoma cell line.
Carcinoma, Squamous Cell
Ultraviolet radiation and 12-O-tetradecanoylphorbol-13-acetate-induced interaction of mouse epidermal protein kinase C ? with Stat3 involve integration with Erk1/2.
Carcinoma, Squamous Cell
[Role of protein kinase C-delta in hyperthermia-induced apoptosis in tongue squamous cell carcinoma Tca8113 cells].
Carcinoma, Squamous Cell
[The role of signal transduction systems in the regulation of production and secretion of TA-4 by cultured cervical epidermoid carcinoma cells (CaSki)]
Carcinoma, Transitional Cell
Heterogeneity of cellular proliferation within transitional cell carcinoma: correlation of protein kinase C alpha/betaI expression and activity.
Carcinoma, Transitional Cell
Patterns of protein kinase C isoenzyme expression in transitional cell carcinoma of bladder. Relation to degree of malignancy.
Carcinosarcoma
Inhibition of protein kinase C-dependent protein phosphorylation correlates with increased polarity and locomotion in Walker 256 carcinosarcoma cells.
Carcinosarcoma
Protein-kinase-C inhibitor calphostin C reduces B16 amelanotic melanoma cell adhesion to endothelium and lung colonization.
Carcinosarcoma
Role of protein kinase C isoforms in locomotion of Walker 256 carcinosarcoma cells.
Carcinosarcoma
Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022).
Cardiac Output, Low
Rationale, design and baseline characteristics of the PRO-TECT II study: PROpofol CardioproTECTion for Type II diabetics A randomized, controlled trial of high-dose propofol versus isoflurane preconditioning in patients undergoing on-pump coronary artery bypass graft surgery.
Cardiomegaly
A Ca(2+)-dependent transgenic model of cardiac hypertrophy: A role for protein kinase Calpha.
Cardiomegaly
A novel protein kinase C target site in protein kinase D is phosphorylated in response to signals for cardiac hypertrophy.
Cardiomegaly
Activation of Peroxisome Proliferator-activated Receptor-alpha Decreases Endothelin-1-induced p38 Mitogen-activated Protein Kinase Activation in Cardiomyocytes.
Cardiomegaly
Activation of the Ca(2+)-activated nonselective cation channel by diacylglycerol analogues in rat cardiomyocytes.
Cardiomegaly
Alcohol-free red wine inhibits isoproterenol-induced cardiac remodeling in rats by the regulation of Akt1 and protein kinase C alpha/beta II.
Cardiomegaly
Alterations of phosphoinositide-specific phospholipase C and protein kinase C in the myocardium of spontaneously hypertensive rats.
Cardiomegaly
Angiotensin II stimulates c-Jun NH2-terminal kinase in cultured cardiac myocytes of neonatal rats.
Cardiomegaly
ARHGAP21 associates with FAK and PKCzeta and is redistributed after cardiac pressure overload.
Cardiomegaly
Calcineurin blockade prevents cardiac mitogen-activated protein kinase activation and hypertrophy in renovascular hypertension.
Cardiomegaly
Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated hypertrophic cardiomyocytes.
Cardiomegaly
Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region.
Cardiomegaly
Cardiac protein kinase C expression in two models of cardiac hypertrophy associated with an activated cardiac renin-angiotensin system: effects of experimental hyperthyroidism and genetic hypertension (the mRen-2 rat).
Cardiomegaly
Caveolin-3 Overexpression Attenuates Cardiac Hypertrophy via Inhibition of T-type Ca2+ Current Modulated by Protein Kinase C? in Cardiomyocytes.
Cardiomegaly
Changes in ventricular 1,2-diacylglycerol content in rats following monocrotaline treatment.
Cardiomegaly
Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms.
Cardiomegaly
Decreased protein kinase C-epsilon expression in hypertrophied cardiac ventricles induced by triiodothyronine treatment in the rat.
Cardiomegaly
Diacylglycerol kinase zeta attenuates pressure overload-induced cardiac hypertrophy.
Cardiomegaly
Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice.
Cardiomegaly
Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade.
Cardiomegaly
Dietary fish oil attenuates cardiac hypertrophy in lipotoxic cardiomyopathy due to systemic carnitine deficiency.
Cardiomegaly
Differential and conditional activation of PKC-isoforms dictates cardiac adaptation during physiological to pathological hypertrophy.
Cardiomegaly
Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in Dahl salt-sensitive rats.
Cardiomegaly
Docosahexaenoic acid inhibits protein kinase C translocation/activation and cardiac hypertrophy in rat cardiomyocytes.
Cardiomegaly
Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1.
Cardiomegaly
Estrogen inhibits cardiomyocyte hypertrophy in vitro. Antagonism of calcineurin-related hypertrophy through induction of MCIP1.
Cardiomegaly
Expression of protein kinase C isoforms in cardiac hypertrophy and heart failure due to volume overload.
Cardiomegaly
Fosinopril and carvedilol reverse hypertrophy and change the levels of protein kinase C epsilon and components of its signaling complex.
Cardiomegaly
Genetic association between 1425G/A SNP in PRKCH and hypertrophic cardiomyopathy in a Chinese population.
Cardiomegaly
Glycogen synthase kinase 3beta together with 14-3-3 protein regulates diabetic cardiomyopathy: effect of losartan and tempol.
Cardiomegaly
Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling.
Cardiomegaly
Inactivation of 14-3-3 protein exacerbates cardiac hypertrophy and fibrosis through enhanced expression of protein kinase C beta 2 in experimental diabetes.
Cardiomegaly
Increased 19 kDa protein phosphorylation and protein kinase C activity in pressure-overload cardiac hypertrophy.
Cardiomegaly
Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCepsilon.
Cardiomegaly
Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat.
Cardiomegaly
Increased translocation of cardiac protein kinase C beta2 accompanies mild cardiac hypertrophy in rats fed saturated fat.
Cardiomegaly
Involvement of the renin-angiotensin system in the development of left ventricular hypertrophy and dysfunction.
Cardiomegaly
Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats.
Cardiomegaly
Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes. Possible role of protein kinase C activation.
Cardiomegaly
Mechanisms of cardiac hypertrophy and injury--possible role of protein kinase C activation.
Cardiomegaly
Multiple signaling pathways coordinately mediate reactive oxygen species dependent cardiomyocyte hypertrophy.
Cardiomegaly
Nuclear localization of protein kinase C-alpha induces thyroid hormone receptor-alpha1 expression in the cardiomyocyte.
Cardiomegaly
Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC.
Cardiomegaly
Pharmacological Protein Kinase C Modulators Reveal a Pro-hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Cardiomegaly
Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes.
Cardiomegaly
Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function.
Cardiomegaly
PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility.
Cardiomegaly
PKC mediates cyclic stretch-induced cardiac hypertrophy through Rho family GTPases and mitogen-activated protein kinases in cardiomyocytes.
Cardiomegaly
PKC translocation without changes in Galphaq and PLC-beta protein abundance in cardiac hypertrophy and failure.
Cardiomegaly
PKCepsilon activation induces dichotomous cardiac phenotypes and modulates PKCepsilon-RACK interactions and RACK expression.
Cardiomegaly
PKCepsilon-PKD1 signaling complex at Z-discs plays a pivotal role in the cardiac hypertrophy induced by G-protein coupling receptor agonists.
Cardiomegaly
Prevention of isoproterenol-induced cardiac hypertrophy by eugenol, an antioxidant.
Cardiomegaly
Protein kinase C and extracellular signal regulated kinase are involved in cardiac hypertrophy of rats with progressive renal injury.
Cardiomegaly
Protein kinase C betaII activation induces angiotensin converting enzyme expression in neonatal rat cardiomyocytes.
Cardiomegaly
Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure.
Cardiomegaly
Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts.
Cardiomegaly
Protein kinase C mRNA and protein expressions in hypobaric hypoxia-induced cardiac hypertrophy in rats.
Cardiomegaly
Protein kinase C promotes cardiac fibrosis and heart failure by modulating galectin-3 expression.
Cardiomegaly
Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy.
Cardiomegaly
Quercetin-supplemented diets lower blood pressure and attenuate cardiac hypertrophy in rats with aortic constriction.
Cardiomegaly
Re: Regulation of protein kinase C isozyme and calcineurin expression in isoproterenol-induced cardiac hypertrophy.
Cardiomegaly
Regulation of protein kinase C isozyme and calcineurin expression in isoproterenol induced cardiac hypertrophy.
Cardiomegaly
Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy.
Cardiomegaly
Roles of protein kinase C and Ca2+-dependent signaling in angiotensin II-induced adrenomedullin production in rat cardiac myocytes.
Cardiomegaly
The Raf-MEK-ERK cascade represents a common pathway for alteration of intracellular calcium by Ras and protein kinase C in cardiac myocytes.
Cardiomegaly
Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta.
Cardiomegaly
Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy.
Cardiomegaly
Triiodothyronine decreases the accumulation of 1,2-diacylglycerol in rat hearts.
Cardiomegaly
Upregulation of phospholipase d expression and activation in ventricular pressure-overload hypertrophy.
Cardiomegaly
[Protein kinase C regulates unloading contraction of cardiomyocytes in hypertrophic heart of spontaneously hypertensive rat.]
Cardiomegaly
[The role of G protein, protein kinase C and Na(+)-H+ exchanger in endothelin-1-induced cardiomyocyte hypertrophic responses]
Cardiomyopathies
Alterations in protein kinase A and protein kinase C levels in heart failure due to genetic cardiomyopathy.
Cardiomyopathies
Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat.
Cardiomyopathies
Designing of Protein Kinase C ?-II Inhibitors against Diabetic complications: Structure Based Drug Design, Induced Fit docking and analysis of active site conformational changes.
Cardiomyopathies
Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of G{alpha}q protein-induced cardiomyopathy.
Cardiomyopathies
Disruption of Ca2+i Homeostasis and Connexin 43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in Plakophilin-2-Deficient Mice.
Cardiomyopathies
Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes.
Cardiomyopathies
Influence of endothelin receptor antagonists on myocardial protein kinase C isoforms in uraemic cardiomyopathy.
Cardiomyopathies
Ischemic protection and myofibrillar cardiomyopathy: dose-dependent effects of in vivo deltaPKC inhibition.
Cardiomyopathies
Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy.
Cardiomyopathies
N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats.
Cardiomyopathies
Opioid peptide gene expression in the primary hereditary cardiomyopathy of the Syrian hamster. I. Regulation of prodynorphin gene expression by nuclear protein kinase C.
Cardiomyopathies
Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure.
Cardiomyopathies
Scaffold Hopping for Identification of Novel PKC?II Inhibitors Based on Ligand and Structural Approaches, Virtual Screening and Molecular Dynamics Study.
Cardiomyopathies
Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy.
Cardiomyopathies
Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy.
Cardiomyopathies
Upregulation of PKC genes and isozymes in cardiovascular tissues during early stages of experimental diabetes.
Cardiomyopathy, Dilated
A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C.
Cardiomyopathy, Dilated
Epsilon protein kinase C in pathological myocardial hypertrophy. Analysis by combined transgenic expression of translocation modifiers and Galphaq.
Cardiomyopathy, Dilated
Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure.
Cardiomyopathy, Dilated
Interplay between the effects of a Protein Kinase C phosphomimic (T204E) and a dilated cardiomyopathy mutation (K211? or R206W) in rat cardiac troponin T blunts the magnitude of muscle length-mediated crossbridge recruitment against the ?-myosin heavy chain background.
Cardiomyopathy, Dilated
Interplay Between the Effects of Dilated Cardiomyopathy Mutation (R206L) and the Protein Kinase C Phosphomimic (T204E) of Rat Cardiac Troponin T Are Differently Modulated by ?- and ?-Myosin Heavy Chain Isoforms.
Cardiomyopathy, Dilated
Pitavastatin-attenuated cardiac dysfunction in mice with dilated cardiomyopathy via regulation of myocardial calcium handling proteins.
Cardiomyopathy, Dilated
PKCepsilon increases phosphorylation of the cardiac myosin binding protein C at serine 302 both in vitro and in vivo.
Cardiomyopathy, Dilated
Principal strain changes precede ventricular wall thinning during transition to heart failure in a mouse model of dilated cardiomyopathy.
Cardiomyopathy, Dilated
Protein kinase C epsilon induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism.
Cardiomyopathy, Dilated
Protein kinase C in the human heart: differential regulation of the isoforms in aortic stenosis or dilated cardiomyopathy.
Cardiomyopathy, Hypertrophic
Cyclic AMP-dependent phosphodiesterase isozyme-specific potentiation by protein kinase C in hypertrophic cardiomyopathic hamster hearts.
Cardiomyopathy, Hypertrophic, Familial
Phosphorylation and mutation of human cardiac troponin I deferentially destabilize the interaction of the functional regions of troponin I with troponin C.
Cardiomyopathy, Restrictive
Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy.
Cardiotoxicity
Attenuation of Sunitinib-induced cardiotoxicity through the A3 adenosine receptor activation.
Cardiotoxicity
The central role of protein kinase C epsilon in cyanide cardiotoxicity and its treatment.
Cardiovascular Abnormalities
Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats.
Cardiovascular Diseases
Age- and sex-dependent alterations in protein kinase C (PKC) and extracellular regulated kinase 1/2 (ERK1/2) in rat myocardium.
Cardiovascular Diseases
Alcohol and the cardiovascular system research challenges and opportunities.
Cardiovascular Diseases
Cardiac oxidative stress in diabetes: Mechanisms and therapeutic potential.
Cardiovascular Diseases
Diversity of the protein kinase C gene family Implications for cardiovascular disease.
Cardiovascular Diseases
Insulin-induced Akt activation is inhibited by angiotensin II in the vasculature through protein kinase C-alpha.
Cardiovascular Diseases
Inwardly rectifying potassium channels in the regulation of vascular tone.
Cardiovascular Diseases
Isoform-specific functions of protein kinase C: the platelet paradigm.
Cardiovascular Diseases
Lysophosphatidylcholine inhibits insulin-induced Akt activation through protein kinase C-alpha in vascular smooth muscle cells.
Cardiovascular Diseases
Mitochondrial APE1/Ref-1 suppressed protein kinase C-induced mitochondrial dysfunction in mouse endothelial cells.
Cardiovascular Diseases
Novel role of protein kinase C-delta Tyr 311 phosphorylation in vascular smooth muscle cell hypertrophy by angiotensin II.
Cardiovascular Diseases
Oxidative stress in cardiovascular diseases and obesity: role of p66Shc and protein kinase C.
Cardiovascular Diseases
Protein Kinase C - Possible Therapeutic Target to Treat Cardiovascular Diseases.
Cardiovascular Diseases
Protein kinase C mediated inhibition of endothelial L-arginine transport is mediated by MARCKS protein.
Cardiovascular Diseases
Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats.
Cardiovascular Diseases
Role of rho kinase in the functional and dysfunctional tonic smooth muscles.
Cardiovascular Diseases
The expression of microRNAs and exposure to environmental contaminants related to human health: a review.
Cardiovascular Diseases
Vitamin E and vascular homeostasis: implications for atherosclerosis.
Cardiovascular Diseases
[Effects of calcium channel blockers in atherosclerosis and cardiovascular event and oxidative vascular damage]
Carotid Stenosis
CX3CL1/CX3CR1-mediated microglia activation plays a detrimental role in ischemic mice brain via p38MAPK/PKC pathway.
Cataract
Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor of protein kinase A.
Cell Transformation, Neoplastic
Expression of platelet-derived growth factor-independent phenotypes in BALB/c 3T3 cell variant with high susceptibility to chemically or physically induced neoplastic cell transformation: dissociation from activation of protein kinase C.
Central Nervous System Diseases
Comprehensive Account on the Synthesis of (-)-Balanol and its Analogues.
Cerebellar Ataxia
A novel H101Q mutation causes PKCgamma loss in spinocerebellar ataxia type 14.
Cerebellar Ataxia
Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14.
Cerebellar Ataxia
Novel PRKCG/SCA14 mutation in a Dutch spinocerebellar ataxia family: expanding the phenotype.
Cerebellar Ataxia
Oxidative activation of protein kinase Cgamma through the C1 domain. Effects on gap junctions.
Cerebellar Ataxia
Protein kinase C activity is a protective modifier of Purkinje neuron degeneration in cerebellar ataxia.
Cerebral Hemorrhage
The action of thrombin in intracerebral hemorrhage induced brain damage is mediated via PKC?/PKC? signaling.
Cerebral Hemorrhage
The SNP (rs2230500) in PRKCH decreases the risk of carotid intima-media thickness in a Chinese young adult population.
Cerebral Infarction
Association between PRKCH gene polymorphisms and subcortical silent brain infarction.
Cerebral Infarction
Contribution of 1425G/A Polymorphism in Protein Kinase C-Eta (PRKCH) Gene and Brain White Matter Lesions to the Risk of Sudden Sensorineural Hearing Loss in a Japanese Nested Case-Control Study.
Cerebral Infarction
Functional recovery and alterations in the expression and localization of protein kinase C following voluntary exercise in rat with cerebral infarction.
Cerebral Infarction
Geranylgeranylacetone, a noninvasive heat shock protein inducer, induces protein kinase C and leads to neuroprotection against cerebral infarction in rats.
Cerebral Infarction
Protection mechanism of early hyperbaric oxygen therapy in rats with permanent cerebral ischemia.
Cerebral Infarction
Protein kinase C activator, bryostatin-1, promotes exercise-dependent functional recovery in rats with cerebral infarction.
Cerebral Infarction
[Effect of Electroacupuncture at "Shuigou" (GV 26) on Immunoactivity and Content of Protein Kinase C in the Middle Cerebral Artery in Acute Cerebral Infarction Rats].
Cervical Intraepithelial Neoplasia
Over-expression of protein kinase C?isoforms (?, ?, ? and ?) in squamous cervical cancer.
Chediak-Higashi Syndrome
A thiol proteinase inhibitor, E-64-d, corrects the abnormalities in concanavalin A cap formation and the lysosomal enzyme activity in leucocytes from patients with Chediak-Higashi syndrome by reversing the down-regulated protein kinase C activity.
Chediak-Higashi Syndrome
Abnormal down-regulation of PKC is responsible for giant granule formation in fibroblasts from CHS (beige) mice--a thiol proteinase inhibitor, E-64-d, prevents giant granule formation in beige fibroblasts.
Chediak-Higashi Syndrome
Chediak-Higashi syndrome natural killer cells: a protein kinase C defective activation/regulation defect?
Chediak-Higashi Syndrome
Effect of a thiol proteinase inhibitor, E-64-d, on susceptibility to infection with Staphylococcus aureus in Chediak-Higashi syndrome (beige) mice.
Chediak-Higashi Syndrome
Enhanced diacylglycerol production by phospholipase D activation is responsible for abnormal increase in concanavalin A cap formation in polymorphonuclear leukocytes from Chediak-Higashi syndrome (beige) mice.
Chediak-Higashi Syndrome
Improvement of deficient natural killer activity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro.
Chediak-Higashi Syndrome
Thiol proteinase inhibitors reverse the increased protein kinase C down-regulation and concanavalin A cap formation in polymorphonuclear leukocytes from Chediak-Higashi syndrome (beige) mouse.
Cholangiocarcinoma
Activation of protein kinase Calpha couples cell volume to membrane Cl- permeability in HTC hepatoma and Mz-ChA-1 cholangiocarcinoma cells.
Cholangiocarcinoma
Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through HO-1 blockage in cholangiocarcinoma cells.
Cholangiocarcinoma
Gastrin inhibits cholangiocarcinoma growth through increased apoptosis by activation of Ca2+-dependent protein kinase C-alpha.
Cholangiocarcinoma
H3 Histamine Receptor-Mediated Activation of Protein Kinase C{alpha} Inhibits the Growth of Cholangiocarcinoma In vitro and In vivo.
Cholangiocarcinoma
Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways.
Cholera
12-O-tetradecanoyl phorbol-13-acetate potentiates adenosine 3',5'-monophosphate-mediated chorionic gonadotropin secretion by cultured human choriocarcinoma cells.
Cholera
Actions of phorbol esters on levels of cAMP in cholera toxin-treated chief cells from guinea pig stomach.
Cholera
Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels.
Cholera
Activation of PKCbeta(II) and PKCtheta is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation.
Cholera
Activation of protein kinase C via the T-cell receptor complex potentiates cyclic AMP responses in T-cells.
Cholera
Activation of protein kinase-C stimulates human granulosa-luteal cell prostacyclin production.
Cholera
Alpha melanocyte stimulating hormone (alpha MSH) stimulates normal human melanocyte growth by binding to high-affinity receptors.
Cholera
Calcitonin gene-related peptide stimulates intracellular cAMP via a protein kinase C-controlled mechanism in human ocular ciliary epithelial cells.
Cholera
Cholera toxin and dibutyryl cyclic adenosine 3',5'-monophosphate sensitize gonadotropin-releasing hormone-stimulated inositol phosphate production to inhibition in protein kinase-C (PKC)-depleted cells: evidence for cross-talk between a cholera toxin-sensitive G-protein and PKC.
Cholera
Cholera toxin discriminates between murine T lymphocyte proliferation stimulated by activators of protein kinase C and proliferation stimulated by IL-2. Possible role for intracellular cAMP.
Cholera
Collagen type IV stimulates an increase in intracellular Ca2+ in pancreatic acinar cells via activation of phospholipase C.
Cholera
Compound 48/80 activates mast cell phospholipase D via heterotrimeric GTP-binding proteins.
Cholera
Contribution of known mitogenic signaling pathways to induction of DNA synthesis in quiescent Chinese hamster fibroblasts.
Cholera
Depletion of protein kinase C-alpha by antisense oligonucleotides alters beta-adrenergic function and reverses the phorbol ester-induced reduction of isoproterenol-induced adenosine 3'-5'-cyclic monophosphate accumulation in murine Swiss 3T3 fibroblasts.
Cholera
Differential effects of transforming growth factor-beta on the synthesis of connective tissue growth factor and vascular endothelial growth factor by peritoneal mesothelial cell.
Cholera
Differential regulation of hCG and progesterone secretion by cholera toxin and phorbol ester in human cytotrophoblasts.
Cholera
Dual signalling by the adenosine A2a receptor involves activation of both N- and P-type calcium channels by different G proteins and protein kinases in the same striatal nerve terminals.
Cholera
Early activation events render T cells susceptible to HIV-1-induced syncytia formation. Role of protein kinase C.
Cholera
Effects of chronic receptor blockade on excitation-contraction coupling in rat aortic rings.
Cholera
Effects of insulin, pertussis toxin and cholera toxin on protein synthesis and diacylglycerol production in 3T3 fibroblasts: evidence for a G-protein mediated activation of phospholipase C in the insulin signal mechanism.
Cholera
Effects of protein kinase C activation on cyclic AMP and testosterone production of rat Leydig cells in vitro.
Cholera
Effects of respiratory burst inhibitors on nitric oxide production by human neutrophils.
Cholera
Evaluation of cyclic AMP accumulation in EBV-transformed human B-lymphocytes: effects of dopamine agonists, isoproterenol, prostaglandin E1, cholera toxin, forskolin, and phorbol 12-myristate-13 acetate.
Cholera
Evidence for protein kinase C pathway in the response of human peripheral blood mononuclear cells to cholera toxin.
Cholera
Functional characterization of the Na(+)-H+ exchanger in rat mast cells: crosstalks between different kinase pathways.
Cholera
Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.
Cholera
Increased cyclic AMP response to forskolin in Epstein-Barr virus-transformed human B-lymphocytes derived from schizophrenics.
Cholera
Induction of B(1)-kinin receptors in vascular smooth muscle cells: cellular mechanisms of map kinase activation.
Cholera
Inhibition of the H+/peptide cotransporter in the human intestinal cell line Caco-2 by cyclic AMP.
Cholera
Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers.
Cholera
Interactions of protein kinase C with receptor- and non-receptor-mediated cyclic AMP generation in swine granulosa cells.
Cholera
Interleukin (IL)-8-induced in vitro human lymphocyte migration is inhibited by cholera and pertussis toxins and inhibitors of protein kinase C.
Cholera
Kinin B1 receptors stimulate nitric oxide production in endothelial cells: signaling pathways activated by angiotensin I-converting enzyme inhibitors and peptide ligands.
Cholera
L-channel modulation by alpha-1 adrenoceptor activation in neonatal rat ventricular cells: intracellular mechanisms.
Cholera
Light-dependent translocation of arrestin in rod photoreceptors is signaled through a phospholipase C cascade and requires ATP.
Cholera
Mechanisms mediating pituitary adenylate cyclase-activating polypeptide depolarization of rat sympathetic neurons.
Cholera
Mechanisms of cholera toxin prevention of thrombin- and PMA-induced endothelial cell barrier dysfunction.
Cholera
Modulation of steroidogenesis in choriocarcinoma cells by cholera toxin, phorbol ester, epidermal growth factor and insulin-like growth factor I.
Cholera
Molecular modulation of inward and outward apical transporters of L-dopa in LLC-PK(1) cells.
Cholera
Nerve growth factor is a potent inducer of proliferation and neuronal differentiation for adult rat chromaffin cells in vitro.
Cholera
Phosphatase inhibitors potentiate adrenergic-stimulated cAMP and cGMP production in rat pinealocytes.
Cholera
Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: inhibition by pertussis toxin.
Cholera
Protein kinase C antagonizes pertussis-toxin-sensitive coupling of the calcitonin receptor to adenylyl cyclase.
Cholera
Regulation of aromatase cytochrome P-450 and 17 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels in choriocarcinoma cells.
Cholera
Regulation of insulin-like growth factor-binding protein-1 production in human granulosa-luteal cells.
Cholera
Regulation of mRNA expression of 3 beta-hydroxy-5-ene steroid dehydrogenase in porcine granulosa cells in culture: a role for the protein kinase-C pathway.
Cholera
Regulation of the cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin mRNAs in cultured choriocarcinoma cells.
Cholera
Relation between chloride secretion and intracellular cyclic adenosine monophosphate in a cloned human intestinal cell line HT-29 cl 19A.
Cholera
Simultaneous expression and regulation of G-CSF and IL-6 mRNA in adherent human monocytes and fibroblasts.
Cholera
Slow oscillations of free intracellular calcium ion concentration in human fibroblasts responding to mechanical stretch.
Cholera
Synergistic stimulation of S-adenosylmethionine decarboxylase activity by Ca2+ ionophore A23187, cholera toxin and 1-oleoyl-2-acetylglycerol.
Cholera
T cell antigen receptor dependent signalling in human lymphocytes: cholera toxin inhibits interleukin-2 receptor expression but not interleukin-2 synthesis by preventing activation of a protein kinase C isotype, PKC-alpha.
Cholera
Transcriptional regulation of Na/K-ATPase by corticosteroids, glycyrrhetinic acid and second messenger pathways in rat kidney epithelial cells.
Cholera
Transforming growth factor beta may act as an autocrine-survival-promoting factor for transformed trophoblasts.
Cholera
Variations in guanine-binding proteins (Gs, Gi) in cultured bovine adrenal cells. Consequences on the effects of phorbol ester and angiotensin II on adrenocorticotropin-induced and cholera-toxin-induced cAMP production.
Cholera
Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA.
Cholera
[The role of signal transduction systems in the regulation of production and secretion of TA-4 by cultured cervical epidermoid carcinoma cells (CaSki)]
Cholera
[The role of signal transduction systems in the regulation of the production and secretion of hCG (alpha, beta) by cultured human choriocarcinoma cells (BeWo)]
Cholestasis
Ca(2+)-dependent protein kinase C isoforms are critical to estradiol 17beta-D-glucuronide-induced cholestasis in the rat.
Cholestasis
EGFR participates downstream of ER? in estradiol-17?-D-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets.
Cholestasis
G-protein-coupled receptor 30/adenylyl cyclase/protein kinase A pathway is involved in estradiol 17ß-D-glucuronide-induced cholestasis.
Cholestasis
Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways.
Cholestasis
Inhibition of procoagulant activity of human monocytes by chenodeoxycholic acid: involvement of protein kinase C.
Cholestasis
Phosphoinositide 3-kinase/protein kinase B signaling pathway is involved in estradiol 17?-D-glucuronide-induced cholestasis: complementarity with classical protein kinase C.
Cholestasis
Sequential activation of classic PKC and estrogen receptor ? is involved in estradiol 17ß-D-glucuronide-induced cholestasis.
Cholestasis, Intrahepatic
ATPase Class I Type 8B Member 1 and Protein Kinase C-zeta Induce the Expression of the Canalicular Bile Salt Export Pump in Human Hepatocytes.
Cholesteatoma
Characterization of patterns of expression of protein kinase C-alpha, -delta, -eta, -gamma and -zeta and their correlations to p53, galectin-3, the retinoic acid receptor-beta and the macrophage migration inhibitory factor (MIF) in human cholesteatomas.
Cholesteatoma
Terminal differentiation of epithelial cells in middle ear cholesteatoma: investigation of patterns of expression of protein kinase C-delta and protein kinase C-eta.
Cholesteatoma, Middle Ear
Terminal differentiation of epithelial cells in middle ear cholesteatoma: investigation of patterns of expression of protein kinase C-delta and protein kinase C-eta.
Choline Deficiency
Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous hepatocarcinogenesis in choline-deficient rats.
Choline Deficiency
Choline deficiency activates phospholipases A2 and C in rat liver without affecting the activity of protein kinase C.
Choline Deficiency
Choline: an important nutrient in brain development, liver function and carcinogenesis.
Choline Deficiency
Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver.
Chondrosarcoma, Mesenchymal
Mesenchymal chondrosarcoma: molecular characterization by a proteomic approach, with morphogenic and therapeutic implications.
Choriocarcinoma
12-O-tetradecanoyl phorbol-13-acetate potentiates adenosine 3',5'-monophosphate-mediated chorionic gonadotropin secretion by cultured human choriocarcinoma cells.
Choriocarcinoma
Cyclic AMP and phorbol esters interact synergistically to regulate expression of the chorionic gonadotropin genes.
Choriocarcinoma
DNA binding of TEA/ATTS domain factors is regulated by protein kinase C phosphorylation in human choriocarcinoma cells.
Choriocarcinoma
Downregulation of protein kinase C by phorbol ester increases expression of epidermal growth factor receptors in transformed trophoblasts and amplifies human chorionic gonadotropin production.
Choriocarcinoma
Epidermal growth factor but not insulin-like growth factor-I potentiates adenosine 3',5'-monophosphate-mediated chorionic gonadotropin secretion by cultured human choriocarcinoma cells.
Choriocarcinoma
Modulation of serotonin transporter activity by a protein kinase C activator and an inhibitor of type 1 and 2A serine/threonine phosphatases.
Choriocarcinoma
Modulation of steroidogenesis in choriocarcinoma cells by cholera toxin, phorbol ester, epidermal growth factor and insulin-like growth factor I.
Choriocarcinoma
Regulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity and mRNA in human choriocarcinoma cells.
Choriocarcinoma
Regulation of aromatase cytochrome P-450 and 17 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels in choriocarcinoma cells.
Choriocarcinoma
Regulation of the cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin mRNAs in cultured choriocarcinoma cells.
Choriocarcinoma
Transport of taurine and its regulation by protein kinase C in the JAR human placental choriocarcinoma cell line.
Choriocarcinoma
[The role of signal transduction systems in the regulation of the production and secretion of hCG (alpha, beta) by cultured human choriocarcinoma cells (BeWo)]
Chronic Periodontitis
Chemoluminescence generation and MTT dye reduction by polymorphonuclear leukocytes from periodontal disease patients.
Cleft Palate
Novel mechanism of protein kinase C inhibition involving the pseudosubstrate region by secalonic acid D in vitro.
Colitis
Alterations in protein kinase C isoforms in experimentally-induced colitis in the rat.
Colitis
Mice deficient in PKC theta demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases.
Colitis
Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis.
Colitis
Protein kinase C theta plays a fundamental role in different types of chronic colitis.
Colitis
The contribution of protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis.
Colonic Neoplasms
1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent Caco-2 cell differentiation.
Colonic Neoplasms
Activation of protein kinase C augments butyrate-induced differentiation and turnover in human colonic epithelial cells in vitro.
Colonic Neoplasms
Analysis of calcium-dependent protein kinase-C isoenzymes in intrinsically resistant cloned lines of LoVo cells: reversal of resistance by kinase inhibitor 1-(5-isoquinolinylsulfonyl) 2-methylpiperazine.
Colonic Neoplasms
Antiproliferative crude soy saponin extract modulates the expression of IkappaBalpha, protein kinase C, and cyclooxygenase-2 in human colon cancer cells.
Colonic Neoplasms
Bile acids modulate the Golgi membrane fission process via a protein kinase Ceta and protein kinase D-dependent pathway in colonic epithelial cells.
Colonic Neoplasms
Butyrate-induced alterations of phosphoinositide metabolism, protein kinase C activity and reduced CD44 variant expression in HT-29 colon cancer cells.
Colonic Neoplasms
CD44 stimulation induces integrin-mediated adhesion of colon cancer cell lines to endothelial cells by up-regulation of integrins and c-Met and activation of integrins.
Colonic Neoplasms
Chronic but not acute conjugated linoleic acid treatment inhibits deoxycholic acid-induced protein kinase C and nuclear factor-kappaB activation in human colorectal cancer cells.
Colonic Neoplasms
Clinicopathological characteristics of KIT and protein kinase C-? expression in adenoid cystic carcinoma: comparison with chromophobe renal cell carcinoma and gastrointestinal stromal tumour.
Colonic Neoplasms
Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes.
Colonic Neoplasms
Cyclo-oxygenase-independent inhibition of apoptosis and stimulation of proliferation by leptin in human colon cancer cells.
Colonic Neoplasms
Decreased PKC-alpha expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells.
Colonic Neoplasms
Detection of genes expressed in primary colon cancers by in situ hybridisation: overexpression of RACK 1.
Colonic Neoplasms
Dexniguldipine hydrochloride inhibits growth of human ht-29 colon-carcinoma cells and expression of protein-kinase-C-delta and protein-kinase-C-zeta.
Colonic Neoplasms
Dietary copper and dimethylhydrazine affect protein kinase C isozyme protein and mRNA expression and the formation of aberrant crypts in colon of rats.
Colonic Neoplasms
Dietary fat and fiber alter rat colonic protein kinase C isozyme expression.
Colonic Neoplasms
Dietary fat and fiber modulate the effect of carcinogen on colonic protein kinase C lambda expression in rats.
Colonic Neoplasms
Dietary fish oil blocks carcinogen-induced down-regulation of colonic protein kinase C isozymes.
Colonic Neoplasms
Differing roles of protein kinase C on the antiproliferative effects of tumor necrosis factor alpha and beta on LoVo cells.
Colonic Neoplasms
Distinct protein kinase C isozymes signal mitogenesis and apoptosis in human colon cancer cells.
Colonic Neoplasms
Effect of gastrin on protein kinase C and its subtype in human colon cancer cell line SW480.
Colonic Neoplasms
Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis.
Colonic Neoplasms
Epithelial-to-Mesenchymal Transition and Resistance to Ingenol 3-Angelate, a Novel Protein Kinase C Modulator, in Colon Cancer Cells.
Colonic Neoplasms
Evidence that protein kinase C-alpha activation is a critical event in phorbol ester-induced multiple drug resistance in human colon cancer cells.
Colonic Neoplasms
Expression of protein kinase C gamma promotes cell migration in colon cancer.
Colonic Neoplasms
Extracellular pyruvate kinase M2 facilitates cell migration by upregulating claudin-1 expression in colon cancer cells.
Colonic Neoplasms
High mobility group box-1 is phosphorylated by protein kinase C zeta and secreted in colon cancer cells.
Colonic Neoplasms
In vitro model for intrinsic drug resistance: effects of protein kinase C activators on the chemosensitivity of cultured human colon cancer cells.
Colonic Neoplasms
Increased levels of phorbin, c-myc, and ornithine decarboxylase RNAs in human colon cancer.
Colonic Neoplasms
Induction of ornithine decarboxylase in normal and protein kinase C--depleted human colon carcinoma cells.
Colonic Neoplasms
Inhibition of protein kinase C-alpha isoform enhances the P-glycoprotein expression and the survival of LoVo human colon adenocarcinoma cells to doxorubicin exposure.
Colonic Neoplasms
Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells.
Colonic Neoplasms
Mechanisms in the chemoprevention of colon cancer: modulation of protein kinase C, tyrosine protein kinase and diacylglycerol kinase activities by 1,4-phenylenebis-(methylene)selenocyanate and impact of low-fat diet.
Colonic Neoplasms
Modulation of HT-29 human colonic cancer cell differentiation with calmidazolium and 12-O-tetradecanoylphorbol-13-acetate.
Colonic Neoplasms
Non-invasive detection of fecal protein kinase C betaII and zeta messenger RNA: putative biomarkers for colon cancer.
Colonic Neoplasms
Overexpression of protein kinase C beta 1 in the SW480 colon cancer cell line causes growth suppression.
Colonic Neoplasms
Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression.
Colonic Neoplasms
p21(Waf1/Cip1) and p53 are downstream effectors of protein kinase C delta in tumor suppression and differentiation in human colon cancer cells.
Colonic Neoplasms
Phorbol 12-myristate 13-acetate induces alteration in mucin gene expression and biological properties of colon cancer cells.
Colonic Neoplasms
Phorbol esters activate proteoglycan metabolism in human colon cancer cells en route to terminal differentiation.
Colonic Neoplasms
Phospholipid fatty acid composition and protein kinase C activity in the large intestine of rats fed on butter and coconut-oil diets.
Colonic Neoplasms
PKC-delta inhibits anchorage-dependent and -independent growth, enhances differentiation, and increases apoptosis in CaCo-2 cells.
Colonic Neoplasms
PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1.
Colonic Neoplasms
PKCdelta requires p53 for suppression of the transformed phenotype in human colon cancer cells.
Colonic Neoplasms
Potent induction of human colon cancer cell uptake of chemotherapeutic drugs by N-myristoylated protein kinase C-alpha (PKC-alpha) pseudosubstrate peptides through a P-glycoprotein-independent mechanism.
Colonic Neoplasms
Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway.
Colonic Neoplasms
Protein kinase C ? regulates survivin expression and inhibits apoptosis in colon cancer.
Colonic Neoplasms
Protein kinase C activation selectively increases mRNA levels for one of the regulatory subunits (RI alpha) of cAMP-dependent protein kinases in HT-29 cells.
Colonic Neoplasms
Protein kinase C activation upregulates intercellular adhesion of alpha-catenin-negative human colon cancer cell variants via induction of desmosomes.
Colonic Neoplasms
Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression.
Colonic Neoplasms
Protein kinase C betaII and TGFbetaRII in omega-3 fatty acid-mediated inhibition of colon carcinogenesis.
Colonic Neoplasms
Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators.
Colonic Neoplasms
Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205.
Colonic Neoplasms
Protein Kinase C Inhibitors Selectively Modulate Dynamics of Cell Adhesion Molecules and Cell Death in Human Colon Cancer Cells.
Colonic Neoplasms
Protein kinase Cbeta is an effective target for chemoprevention of colon cancer.
Colonic Neoplasms
Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo.
Colonic Neoplasms
Protein kinase Cgamma in colon cancer cells: expression, Thr514 phosphorylation and sensitivity to butyrate-mediated upregulation as related to the degree of differentiation.
Colonic Neoplasms
Protein Kinase-zeta inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells.
Colonic Neoplasms
Regulation of tight junction resistance in T84 monolayers by elevation in intracellular Ca2+: a protein kinase C effect.
Colonic Neoplasms
Requirement of the enzymatic and signaling activities of plasmin for phorbol-ester-induced scattering of colon cancer cells.
Colonic Neoplasms
Role of Caveolin 1, E-Cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells.
Colonic Neoplasms
Rottlerin induces Heme Oxygenase-1(HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC delta-independent pathway in human colon cancer HT29 cells.
Colonic Neoplasms
Short-chain fatty acids reduce expression of specific protein kinase C isoforms in human colonic epithelial cells.
Colonic Neoplasms
Staurosporine increases carcinoembryonic antigen expression in a human colon cancer cell line.
Colonic Neoplasms
Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells.
Colonic Neoplasms
Stimulation of protein kinase C-alpha suppresses colon cancer cell proliferation by down-regulation of beta-catenin.
Colonic Neoplasms
Stimulation of protein kinase Calpha suppresses colon cancer cell proliferation by down-regulation of beta-catenin.
Colonic Neoplasms
The modulation of growth by HMBA in PKC overproducing HT29 colon cancer cells.
Colonic Neoplasms
The Role of M3 Muscarinic Receptor Ligand-Induced Kinase Signaling in Colon Cancer Progression.
Colonic Neoplasms
The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells.
Colonic Neoplasms
The roles of specific isoforms of protein kinase C in growth control and human colon cancer.
Colonic Neoplasms
The tumor promoter receptor protein kinase C: a novel target for chemoprevention and therapy of human colon cancer.
Colonic Neoplasms
Tissue factor activity of SW-480 human colon adenocarcinoma cells is modulated by thrombin and protein kinase C activation.
Colonic Neoplasms
TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: selective role of PKC-alpha and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides treatment.
Colonic Neoplasms
Ursodeoxycholic acid inhibits translocation of protein kinase C in human colonic cancer cell lines.
Colonic Neoplasms
[The effect of PKC-delta inhibitor Rottlerin on human colon cancer cell line SW1116 and its mechanism]
Colorectal Neoplasms
A new mechanism of SOX9 action to regulate PKCalpha expression in the intestine epithelium.
Colorectal Neoplasms
A window of opportunity phase II study of enzastaurin in chemonaive patients with asymptomatic metastatic colorectal cancer.
Colorectal Neoplasms
Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells.
Colorectal Neoplasms
Activation of protein kinase C modulates cell-cell and cell-substratum adhesion of a human colorectal carcinoma cell line and restores 'normal' epithelial morphology.
Colorectal Neoplasms
Analyses of protein kinase C isoform expression in a colorectal cancer liver metastasis model.
Colorectal Neoplasms
Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells.
Colorectal Neoplasms
Chronic but not acute conjugated linoleic acid treatment inhibits deoxycholic acid-induced protein kinase C and nuclear factor-kappaB activation in human colorectal cancer cells.
Colorectal Neoplasms
Correlation between protein kinase C activity and histopathological criteria in human colorectal adenoma.
Colorectal Neoplasms
Decreased levels of protein kinase C enzyme activity and protein kinase C mRNA in primary colon tumors.
Colorectal Neoplasms
Differential expression of protein kinase C isoforms in human colorectal cancers.
Colorectal Neoplasms
Down-regulation of protein kinase C-alpha detected in human colorectal cancer.
Colorectal Neoplasms
Effect of protein kinase C on multidrug resistance of multidrug-resistant colorectal cancer LoVo/Adr cells.
Colorectal Neoplasms
Effects of cell membrane phospholipid level and protein kinase C isoenzyme expression on hepatic metastasis of colorectal carcinoma.
Colorectal Neoplasms
Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids.
Colorectal Neoplasms
Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway.
Colorectal Neoplasms
Nonylphenol promotes the proliferation of colorectal cancer COLO205 cells by upregulating the expression of protein kinase C ?.
Colorectal Neoplasms
Overexpression of PAK-1 is an independent predictor of disease recurrence in colorectal carcinoma.
Colorectal Neoplasms
Pak-1 expression increases with progression of colorectal carcinomas to metastasis.
Colorectal Neoplasms
Phase II randomized study of ISIS 3521 and ISIS 5132 in patients with locally advanced or metastatic colorectal cancer: a National Cancer Institute of Canada clinical trials group study.
Colorectal Neoplasms
Protein kinase C ? inhibition by enzastaurin leads to mitotic missegregation and preferential cytotoxicity toward colorectal cancer cells with chromosomal instability (CIN).
Colorectal Neoplasms
Protein kinase C activity in human colonic adenoma and colorectal carcinoma.
Colorectal Neoplasms
Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice.
Colorectal Neoplasms
Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.
Colorectal Neoplasms
Protein kinase C delta is phosphorylated on five novel Ser/Thr sites following inducible overexpression in human colorectal cancer cells.
Colorectal Neoplasms
Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring.
Colorectal Neoplasms
Protein kinase C-beta II (PKC-beta II) expression in patients with colorectal cancer.
Colorectal Neoplasms
Silencing protein kinase C ? by microRNA-25-5p activates AMPK signaling and inhibits colorectal cancer cell proliferation.
Colorectal Neoplasms
Sodium butyrate-mediated differentiation of colorectal cancer cells: regulation of PKCbetaII by PI 3-kinase.
Colorectal Neoplasms
The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells.
Colorectal Neoplasms
[Target lethal effect of recombinant soluble Fas coupled with protein kinase C inhibitor on colorectal carcinoma cells]
Coma
Brain protein kinase C assay using MARCKS substrate reveals no translocation due to profound insulin-induced hypoglycemia.
Common Variable Immunodeficiency
Abnormal B cell response of protein kinase C in some common variable immunodeficiency.
Common Variable Immunodeficiency
Common variable immunodeficiency associated with myelocathexis and altered membrane sodium-proton antiport.
Common Variable Immunodeficiency
Defects in proliferative responses of T cells from patients with common variable immunodeficiency on direct activation of protein kinase C.
Common Variable Immunodeficiency
Protein kinase C independent restoration of specific immune responsiveness in common variable immunodeficiency.
Contracture
Adreno-muscarinic synergy in the bladder trigone: calcium-dependent and -independent mechanisms.
Contracture
Mechanisms of isoflurane-increased submaximum Ca2+-activated force in rabbit skinned femoral arterial strips.
Contracture
Phorbol 12,13-dibutyrate-induced protein kinase C activation triggers sustained contracture in human myometrium in vitro.
Contracture
Preconditioning of isolated rabbit cardiomyocytes: induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor.
Contracture
Schistosoma mansoni: myogenic characteristics of phorbol ester-induced muscle contraction.
Contracture
Sensitivity to protein kinase C inhibitors of nicardipine-insensitive component of high K+ contracture in rat and guinea-pig aorta.
Contracture
The neuropeptide proctolin potentiates contractions and reduces cGMP concentration via a PKC-dependent pathway.
Coronary Artery Disease
Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators.
Coronary Artery Disease
Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon.
Coronary Artery Disease
Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts.
Coronary Occlusion
Impaired perfusion after myocardial infarction is due to reperfusion-induced deltaPKC-mediated myocardial damage.
Coronary Occlusion
Ischemic preconditioning modulates mitochondrial respiration, irrespective of the employed signal transduction pathway.
Coronary Occlusion
Role of protein kinase C-alpha in activation of ecto-5'-nucleotidase in the preconditioned canine myocardium.
Coronary Vasospasm
Endothelin-1 enhances eicosanoids-induced coronary smooth muscle contraction by activating specific protein kinase C isoforms.
Coronary Vasospasm
Endothelin-1--induced enhancement of coronary smooth muscle contraction via MAPK-dependent and MAPK-independent [Ca(2+)](i) sensitization pathways.
Coronary Vasospasm
Evidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm.
Coronary Vasospasm
Oxidized-LDL enhances coronary vasoconstriction by increasing the activity of protein kinase C isoforms alpha and epsilon.
Coronary Vasospasm
Preconditioning of coronary artery against vasoconstriction by endothelin-1 and prostaglandin F2alpha during repeated downregulation of epsilon-protein kinase C.
Corticobasal Degeneration
Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies.
Cowpox
Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis.
Craniosynostoses
Decreased proliferation and altered differentiation in osteoblasts from genetically and clinically distinct craniosynostotic disorders.
Craniosynostoses
Increased osteoblast apoptosis in apert craniosynostosis: role of protein kinase C and interleukin-1.
Craniosynostoses
Role of N-cadherin and protein kinase C in osteoblast gene activation induced by the S252W fibroblast growth factor receptor 2 mutation in Apert craniosynostosis.
Crohn Disease
Fibrogenesis and fibrosis in inflammatory bowel diseases: Good and bad side of same coin?
Crohn Disease
Granulocyte-macrophage colony-stimulating factor and interleukin-3 potentiate interferon-gamma-mediated endothelin production by human monocytes: role of protein kinase C.
Cryptococcosis
Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C-alpha activation.
Cryptosporidiosis
Genome-Wide Association Study of Cryptosporidiosis in Infants Implicates PRKCA.
Cushing Syndrome
ACTH and phorbol ester stimulated redistribution of protein kinase C in human cortisol-producing adrenal adenoma.
Cushing Syndrome
[Effect of adrenocorticotropic hormone on the caspase-3 level and DNA fragmentation in hyperplasia tissue of human adrenals]
Cystadenoma
Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis.
Cystic Fibrosis
After damage of large bile ducts by gamma-aminobutyric acid, small ducts replenish the biliary tree by amplification of calcium-dependent signaling and de novo acquisition of large cholangiocyte phenotypes.
Cystic Fibrosis
Antisense oligonucleotide to PKC-epsilon alters cAMP-dependent stimulation of CFTR in Calu-3 cells.
Cystic Fibrosis
Clinical implications of basic neuroscience research. I: Protein kinases, ionic channels, and genes.
Cystic Fibrosis
Effect of modulation of protein kinase C on the cAMP-dependent chloride conductance in T84 cells.
Cystic Fibrosis
Expression of the cystic fibrosis transmembrane conductance regulator gene can be regulated by protein kinase C.
Cystic Fibrosis
Further evidence for abnormal protein kinase C regulation of macromolecule secretion in fibroblasts from cystic fibrosis patients.
Cystic Fibrosis
Identification of key pathways and genes in Barrett's esophagus using integrated bioinformatics methods.
Cystic Fibrosis
Modulation of Ca2+-dependent anion secretion by protein kinase C in normal and cystic fibrosis pancreatic duct cells.
Cystic Fibrosis
Phorbol ester-induced protein kinase C translocation and lysosomal enzyme release in normal and cystic fibrosis fibroblasts.
Cystic Fibrosis
Phosphorylation by protein kinase C is required for acute activation of cystic fibrosis transmembrane conductance regulator by protein kinase A.
Cystic Fibrosis
Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA.
Cystic Fibrosis
Phosphorylation of vimentin is an intermediate step in protein kinase C-mediated glycoconjugate secretion.
Cystic Fibrosis
PKC regulation of cardiac CFTR Cl- channel function in guinea pig ventricular myocytes.
Cystic Fibrosis
PKC signaling in CF/T43 cell line: regulation of NKCC1 by PKC-delta isotype.
Cystic Fibrosis
Prostaglandin F2alpha stimulates CFTR activity by PKA- and PKC-dependent phosphorylation.
Cystic Fibrosis
Protein kinase C activates chloride conductance in C127 cells stably expressing the cystic fibrosis gene.
Cystic Fibrosis
Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor.
Cystic Fibrosis
Protein kinase C mediates down-regulation of cystic fibrosis transmembrane conductance regulator levels in epithelial cells.
Cystic Fibrosis
Protein kinase C phosphorylation disrupts Na+/H+ exchanger regulatory factor 1 autoinhibition and promotes cystic fibrosis transmembrane conductance regulator macromolecular assembly.
Cystic Fibrosis
Regulation of chloride channels by protein kinase C in normal and cystic fibrosis airway epithelia.
Cystic Fibrosis
Regulation of recombinant cardiac cystic fibrosis transmembrane conductance regulator chloride channels by protein kinase C.
Cystic Fibrosis
Role for PKC alpha and PKC epsilon in down-regulation of CFTR mRNA in a human epithelial liver cell line.
Cystic Fibrosis
Stimulatory and inhibitory protein kinase C consensus sequences regulate the cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Targeted inactivation of cystic fibrosis transmembrane conductance regulator chloride channel gene prevents ischemic preconditioning in isolated mouse heart.
Cystic Fibrosis
The phorbol ester PMA and cyclic AMP activate different Cl(-) and HCO3(-) fluxes in C127 cells expressing CFTR.
Cystitis
Enhancement of S1P-induced contractile response in detrusor smooth muscle of rats having cystitis.
Cystitis
Rho Kinase and Protein Kinase C Pathways are Responsible for Enhanced Carbachol Contraction in Permeabilized Detrusor in a Rat Model of Cystitis.
Cystitis, Interstitial
Protein kinase C contributes to abnormal capsaicin responses in DRG neurons from cats with feline interstitial cystitis.
Cysts
Abnormal hepatocystin caused by truncating PRKCSH mutations leads to autosomal dominant polycystic liver disease.
Cysts
Acanthamoeba castellanii: Gene profile of encystation by ESTs analysis and KOG assignment.
Cysts
Expression levels of encystation mediating factors in fresh strain of Acanthamoeba castellanii cyst ESTs.
Cysts
Liver progenitor cells develop cholangiocyte-type epithelial polarity in three-dimensional culture.
Cysts
Spermatid cyst polarization in Drosophila depends upon apkc and the CPEB family translational regulator orb2.
Cytomegalovirus Infections
Expression of protein kinase A and protein kinase C during ongoing human cytomegalovirus infection.
Dehydration
Effects of PKC alpha activation on Ca2+ pump and K(Ca) channel in deoxygenated sickle cells.
Dehydration
Endothelin-3 Expression in the Subfornical Organ Enhances the Sensitivity of Nax, the Brain Sodium-Level Sensor, to Suppress Salt Intake.
Dehydration
Infrared spectroscopic study of the interaction of diacylglycerol with phosphatidylserine in the presence of calcium.
Dehydration
Second messenger and cAMP-dependent protein kinase responses to dehydration and anoxia stresses in frogs.
Dementia
Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies.
Dementia
Deletion of the C-26 Methyl Substituent from the Bryostatin Analogue Merle 23 has Negligible Impact on Its Biological Profile or Potency.
Dementia
Effect of Huannao Yicong Prescription () extract on ?-Amyloid precursor protein metabolic signal transduction-related protein in brain tissue of dementia model transgenic mouse.
Dementia
Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones.
Dementia
Fluorescent-responsive synthetic C1b domains of protein kinase C? as reporters of specific high-affinity ligand binding.
Dementia
Screening for protein kinase C ligands using fluorescence resonance energy transfer.
Dementia
Synergistic effects of chronic bryostatin-1 and alpha-tocopherol on spatial learning and memory in rats.
Demyelinating Diseases
Diverse Biological Functions of Sphingolipids in the CNS: Ceramide and Sphingosine Regulate Myelination in Developing Brain but Stimulate Demyelination during Pathogenesis of Multiple Sclerosis.
Demyelinating Diseases
Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling.
Demyelinating Diseases
Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury.
Demyelinating Diseases
Remyelination in vitro following protein kinase C activator-induced demyelination.
Demyelinating Diseases
Responses to cyclic AMP is impaired in the twitcher Schwann cells in vitro.
Dermatitis, Allergic Contact
Down-regulation of Langerhans cell protein kinase C-beta isoenzyme expression in inflammatory and hyperplastic dermatoses.
Dermatitis, Allergic Contact
Overexpression of skin protein kinase C-alpha in anagen hair follicles during induced growth of mouse hair.
Dermatitis, Atopic
Douchi (fermented Glycine max Merr.) alleviates atopic dermatitis-like skin lesions in NC/Nga mice by regulation of PKC and IL-4.
Dermatitis, Atopic
Down-regulation of Langerhans cell protein kinase C-beta isoenzyme expression in inflammatory and hyperplastic dermatoses.
Dermatitis, Atopic
Hyaluronic Acid-Mediated Drug Delivery System Targeting for Inflammatory Skin Diseases: A Mini Review.
Dermatitis, Atopic
Influence of protein kinase C activation on basophils from patients with atopic dermatitis in comparison with nonatopic controls.
Dermatitis, Atopic
TSLP regulates eosinophil migration via phosphorylation of L-plastin in atopic dermatitis.
Dermatitis, Contact
Down-regulation of Langerhans cell protein kinase C-beta isoenzyme expression in inflammatory and hyperplastic dermatoses.
Dermatitis, Contact
Down-regulation of protein kinase C isoforms in irritant contact dermatitis.
Dermatitis, Contact
Flow cytometric analysis of protein kinase C in lymph node cells during the induction phase of contact hypersensitivity reaction.
Dermatitis, Contact
The potential role of skin protein kinase C isoforms alpha and delta in mouse hair growth induced by diphencyprone-allergic contact dermatitis.
Dermatitis, Exfoliative
Down-regulation of Langerhans cell protein kinase C-beta isoenzyme expression in inflammatory and hyperplastic dermatoses.
Dermatitis, Phototoxic
Involvement of reactive oxygen species, protein kinase C, and tyrosine kinase in prostaglandin E2 production in Balb/c 3T3 mouse fibroblast cells by quinolone phototoxicity.
Dermatofibrosarcoma
Mitogenic activity of dermatofibrosarcoma protuberans is mediated via an extracellular signal related kinase dependent pathway.
Diabetes Complications
Activation of human platelet protein kinase C-beta 2 in vivo in response to acute hyperglycemia.
Diabetes Complications
Activation of protein kinase C isoforms and its impact on diabetic complications.
Diabetes Complications
AGEs induce oxidative stress and activate protein kinase C-beta(II) in neonatal mesangial cells.
Diabetes Complications
Altered protein kinase C activation associated with rat embryonic dysmorphogenesis.
Diabetes Complications
Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor.
Diabetes Complications
Aminoacid support in the prevention of diabetes and diabetic complications.
Diabetes Complications
An acute hyperglycemia or acidosis-induced changes of indolamines level correlates with PKC-alpha expression in rat brain.
Diabetes Complications
Antiproliferative naphthopyrans: biological activity, mechanistic studies and therapeutic potential.
Diabetes Complications
Designing of Protein Kinase C ?-II Inhibitors against Diabetic complications: Structure Based Drug Design, Induced Fit docking and analysis of active site conformational changes.
Diabetes Complications
Diabetes and Complications: Cellular Signalling Pathways, Current Understanding and Targeted Therapies.
Diabetes Complications
Diabetic cardiomyocyte dysfunction and myocyte insulin resistance: role of glucose-induced PKC activity.
Diabetes Complications
Diabetic complications and the mechanism of the hyperglycaemia-induced damage to the mt DNA of cultured vascular endothelial cells: (II) The involvement of protein kinase C.
Diabetes Complications
Effects of knockout of the protein kinase C beta gene on glucose transport and glucose homeostasis.
Diabetes Complications
Effects of the diacylglycerol complexing agent, cremophor, on nerve-conduction velocity and perfusion in diabetic rats.
Diabetes Complications
High Glucose Stimulates Mineralocorticoid Receptor Transcriptional Activity Through the Protein Kinase C ? Signaling.
Diabetes Complications
Identification of Protein Kinase C Isoforms Involved in Type 1 Diabetic Encephalopathy in Mice.
Diabetes Complications
Identification of specific features of inhibition of PKC?II and its potential lead by shape-based virtual screening and molecular docking studies.
Diabetes Complications
Increased platelet aggregation in diabetic patients with microangiopathy despite good glycemic control.
Diabetes Complications
Inhibition of protein kinase C ?II isoform ameliorates methylglyoxal advanced glycation endproduct-induced cardiomyocyte contractile dysfunction.
Diabetes Complications
Inhibition of protein kinase C ?II isoform rescues glucose toxicity-induced cardiomyocyte contractile dysfunction: role of mitochondria.
Diabetes Complications
LY290181, an inhibitor of diabetes-induced vascular dysfunction, blocks protein kinase C-stimulated transcriptional activation through inhibition of transcription factor binding to a phorbol response element.
Diabetes Complications
Modulation of basal nitric oxide-dependent cyclic-GMP production by ambient glucose, myo-inositol, and protein kinase C in SH-SY5Y human neuroblastoma cells.
Diabetes Complications
Protein kinase C ?II in diabetic complications: survey of structural, biological and computational studies.
Diabetes Complications
Protein kinase C activation and the development of diabetic complications.
Diabetes Complications
Protein kinase C activity is acutely regulated by plasma glucose concentration in human monocytes in vivo.
Diabetes Complications
Protein kinase C agonists acutely normalize decreased ouabain-inhibitable respiration in diabetic rabbit nerve. Implications for (Na,K)-ATPase regulation and diabetic complications.
Diabetes Complications
Protein kinase C beta inhibition and aorta and corpus cavernosum function in streptozotocin-diabetic mice.
Diabetes Complications
Protein kinase C beta inhibitor prevents diabetic peripheral neuropathy, but not histopathological abnormalities of retina in Spontaneously Diabetic Torii rat.
Diabetes Complications
Protein kinase C beta inhibitors: a new therapeutic target for diabetic nephropathy and vascular complications.
Diabetes Complications
Protein kinase Cbeta mediates hepatic induction of sterol regulatory element-binding protein-1c by insulin.
Diabetes Complications
Protein kinases C: potential targets for intervention in diabetic nephropathy.
Diabetes Complications
Proteomic analysis identifies nuclear protein effectors in PKC-delta signaling under high glucose-induced apoptosis in human umbilical vein endothelial cells.
Diabetes Complications
Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells.
Diabetes Complications
Role for poly(ADP-ribose) polymerase activation in diabetic nephropathy, neuropathy and retinopathy.
Diabetes Complications
Role of complement and complement regulatory proteins in the complications of diabetes.
Diabetes Complications
Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy.
Diabetes Complications
Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor.
Diabetes Complications
Targeting PKC-? II by Peptides and Peptidomimetics Derived from RACK 1: An In Silico Approach.
Diabetes Complications
The beta-specific protein kinase C inhibitor ruboxistaurin (LY333531) suppresses glucose-induced adhesion of human monocytes to endothelial cells in vitro.
Diabetes Complications
The role of lipids and protein kinase Cs in the pathogenesis of diabetic retinopathy.
Diabetes Complications
The Role of Oxidative Stress in the Pathogenesis of Type 2 Diabetes Mellitus Micro- and Macrovascular Complications:Avenues for a Mechanistic-Based Therapeutic Approach.
Diabetes Complications
The role of protein kinase C in the development of the complications of diabetes.
Diabetes Complications
Tonicity-responsive enhancer binding protein regulates the expression of aldose reductase and protein kinase C ? in a mouse model of diabetic retinopathy.
Diabetes Complications
Upregulation of PKC genes and isozymes in cardiovascular tissues during early stages of experimental diabetes.
Diabetes Complications
[Investigation of a novel mechanism of diabetic complications: impacts of mitochondrial reactive oxygen species]
Diabetes Complications
[The role of protein kinase C in the pathophysiology of diabetic retinopathy]
Diabetes Insipidus, Nephrogenic
Absence of PKC-alpha attenuates lithium-induced nephrogenic diabetes insipidus.
Diabetes Mellitus
Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor.
Diabetes Mellitus
Diabetes-induced oxidative stress is mediated by Ca2+-independent phospholipase A2 in neutrophils.
Diabetes Mellitus
Diabetic hearts have lower basal urocortin levels that fail to increase after cardioplegic arrest: Association with increased apoptosis and postsurgical cardiac dysfunction.
Diabetes Mellitus
Down-regulation of endothelin-1 receptors by protein kinase C in streptozotocin diabetic rats.
Diabetes Mellitus
Effect of high glucose on mesangial cell protein kinase C-delta and -epsilon is polyol pathway-dependent.
Diabetes Mellitus
Effects of Blocking the Renin-Angiotensin System on Expression and Translocation of Protein Kinase C Isoforms in the Kidney of Diabetic Rats.
Diabetes Mellitus
Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.
Diabetes Mellitus
Genetic variants in protein kinase C zeta gene and type 2 diabetes risk: a case-control study of a Chinese Han population.
Diabetes Mellitus
Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus.
Diabetes Mellitus
Increased intracellular calcium and altered phorbol dibutyrate binding to intact platelets in young subjects with insulin-dependent and non-insulin-dependent diabetes mellitus.
Diabetes Mellitus
Increased myogenic tone in skeletal muscle arterioles of diabetic rats. Possible role of increased activity of smooth muscle Ca2+ channels and protein kinase C.
Diabetes Mellitus
Is insulin resistance in the spontaneously hypertensive rat related to changes in protein kinase C in skeletal muscle?
Diabetes Mellitus
Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase.
Diabetes Mellitus
Nutritional regulation of coupling factor 6, a novel vasoactive and proatherogenic peptide.
Diabetes Mellitus
Pathogenesis of diabetic nephropathy: the role of oxidative stress and protein kinase C.
Diabetes Mellitus
Physical exercise prevents the development of type 2 diabetes mellitus in Psammomys obesus.
Diabetes Mellitus
PKC? promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null mice.
Diabetes Mellitus
Protein kinase C activation and its pharmacological inhibition in vascular disease.
Diabetes Mellitus
Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus.
Diabetes Mellitus
Protein kinase C beta inhibition and aorta and corpus cavernosum function in streptozotocin-diabetic mice.
Diabetes Mellitus
Protein kinase C beta inhibition: the promise for treatment of diabetic nephropathy.
Diabetes Mellitus
Protein kinase C beta isoenzymes in diabetic kidneys and their relation to nephroprotective actions of the ACE inhibitor lisinopril.
Diabetes Mellitus
Protein kinases C: potential targets for intervention in diabetic nephropathy.
Diabetes Mellitus
Regulation of protein kinase C by short term hyperglycaemia in human platelets in vivo and in vitro.
Diabetes Mellitus
Renal angiotensin II receptors and protein kinase C in diabetic rats: effects of insulin and ACE inhibition.
Diabetes Mellitus
Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy.
Diabetes Mellitus
The beta-specific protein kinase C inhibitor ruboxistaurin (LY333531) suppresses glucose-induced adhesion of human monocytes to endothelial cells in vitro.
Diabetes Mellitus
[Activity of membrane-bound protein kinase C and ATPase in erythrocytes in diabetic angiopathy]
Diabetes Mellitus
[Effects of calcium channel blockers in atherosclerosis and cardiovascular event and oxidative vascular damage]
Diabetes Mellitus
[Red cell Na+/H+ exchange and role of protein kinase C in its stimulation in diabetes mellitus, essential hypertension and nephropathy]
Diabetes Mellitus
[Renal disease in diabetics. Immunological bases of tubule-interstitial fibrosis and glomeruloesclerosis. Current therapeutic approach]
Diabetes Mellitus, Experimental
Protein kinase C isozymes in skeletal muscles during the early stage of genetic and streptozocin diabetes.
Diabetes Mellitus, Type 1
Alterations in rat coronary vasoreactivity and vascular protein kinase C isoforms in Type 1 diabetes.
Diabetes Mellitus, Type 1
Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat.
Diabetes Mellitus, Type 1
Effect of captopril and the bradykinin-PKC pathway on ROS production in type 1 diabetic rats.
Diabetes Mellitus, Type 1
Feature article: Inhibition of protein kinase C beta phosphorylation activates nuclear factor-kappa B and improves postischemic recovery in type 1 diabetes.
Diabetes Mellitus, Type 1
Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium.
Diabetes Mellitus, Type 1
NADPH oxidase and PKC contribute to increased Na transport by the thick ascending limb during type 1 diabetes.
Diabetes Mellitus, Type 1
No support for association of protein kinase C, beta 1 (PRKCB1) gene promoter polymorphisms c.-1504C>T and c.-546C>G with diabetic nephropathy in Type 1 diabetes.
Diabetes Mellitus, Type 1
Protein kinase C-dependent NAD(P)H oxidase activation induced by type 1 diabetes in renal medullary thick ascending limb.
Diabetes Mellitus, Type 1
Stimulation of the human leucocyte Na+/H+ antiport by D-glucose is mediated by protein kinase C.
Diabetes Mellitus, Type 1
Viral vector mediated continuous expression of interleukin-10 in DRG alleviates pain in type 1 diabetic animals.
Diabetes Mellitus, Type 2
Activation of human platelet protein kinase C-beta 2 in vivo in response to acute hyperglycemia.
Diabetes Mellitus, Type 2
Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise.
Diabetes Mellitus, Type 2
Aortic superoxide production at the early hyperglycemic stage in a rat type 2 diabetes model and the effects of pravastatin.
Diabetes Mellitus, Type 2
Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle.
Diabetes Mellitus, Type 2
Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans.
Diabetes Mellitus, Type 2
Correction: Expression of Protein Kinase C Isoforms in Pancreatic Islets and Liver of Male Goto-Kakizaki Rats, a Model of Type 2 Diabetes.
Diabetes Mellitus, Type 2
Deletion of PKC{varepsilon} selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse {beta}-cells.
Diabetes Mellitus, Type 2
Diabetes and Complications: Cellular Signalling Pathways, Current Understanding and Targeted Therapies.
Diabetes Mellitus, Type 2
Evaluation of renal gene expression of protein kinase C (PKC) isoforms in diabetic and nondiabetic proliferative glomerular diseases.
Diabetes Mellitus, Type 2
Expression of Protein Kinase C Isoforms in Pancreatic Islets and Liver of Male Goto-Kakizaki Rats, a Model of Type 2 Diabetes.
Diabetes Mellitus, Type 2
Genetic variants in protein kinase C zeta gene and type 2 diabetes risk: a case-control study of a Chinese Han population.
Diabetes Mellitus, Type 2
Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Impaired translocation of protein kinase C activity in human non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Increased skeletal muscle expression of PKC-theta but not PKC-alpha mRNA in type 2 diabetes: inverse relationship with in-vivo insulin sensitivity.
Diabetes Mellitus, Type 2
Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.
Diabetes Mellitus, Type 2
Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease.
Diabetes Mellitus, Type 2
Inhibition of Protein Kinase C{beta} Does Not Improve Endothelial Function in Type 2 Diabetes.
Diabetes Mellitus, Type 2
Insulin sensitivity is related to fat oxidation and protein kinase C activity in children with acute burn injury.
Diabetes Mellitus, Type 2
Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction.
Diabetes Mellitus, Type 2
Mechanisms involved in the desflurane-induced post-conditioning of isolated human right atria from patients with type 2 diabetes.
Diabetes Mellitus, Type 2
Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression.
Diabetes Mellitus, Type 2
Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium.
Diabetes Mellitus, Type 2
Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction.
Diabetes Mellitus, Type 2
Nutritional regulation of coupling factor 6, a novel vasoactive and proatherogenic peptide.
Diabetes Mellitus, Type 2
Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes.
Diabetes Mellitus, Type 2
Physical exercise prevents the development of type 2 diabetes mellitus in Psammomys obesus.
Diabetes Mellitus, Type 2
PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance.
Diabetes Mellitus, Type 2
PKCepsilon induces interleukin-6 expression through the MAPK pathway in 3T3-L1 adipocytes.
Diabetes Mellitus, Type 2
Platelet protein kinase C isoform content in type 2 diabetes complicated with retinopathy and nephropathy.
Diabetes Mellitus, Type 2
Polymorphisms in the 5'-upstream region of the PKCbeta gene in Japanese patients with Type 2 diabetes.
Diabetes Mellitus, Type 2
Prevention of insulin resistance and beta-cell loss by abrogating PKCepsilon-induced serine phosphorylation of muscle IRS-1 in Psammomys obesus.
Diabetes Mellitus, Type 2
Protein kinase C delta regulates anti-apoptotic alphaB-crystallin in the retina of type 2 diabetes.
Diabetes Mellitus, Type 2
Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes.
Diabetes Mellitus, Type 2
Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia.
Diabetes Mellitus, Type 2
Retraction Note: abstracts of the 47th Annual Meeting of the EASD, Lisbon 2011. 'Reduced syntaxin-5 in skeletal muscle of patients with type 2 diabetes is linked to increased diacylglycerol, activation of PKCtheta and impaired insulin signalling'.
Diabetes Mellitus, Type 2
Role of PKCzeta translocation in the development of type 2 diabetes in rats following continuous glucose infusion.
Diabetes Mellitus, Type 2
The diverse roles of protein kinase C in pancreatic beta-cell function.
Diabetes Mellitus, Type 2
The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling.
Diabetes Mellitus, Type 2
The roles of cell Ca2+, protein kinase C and the Na(+)-H+ antiport in the development of hypertension and insulin resistance.
Diabetes, Gestational
Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium.
Diabetic Angiopathies
Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications.
Diabetic Angiopathies
Activation of protein kinase C by elevation of glucose concentration: Proposal for a mechanism in the development of diabetic vascular complications.
Diabetic Angiopathies
Amelioration of diabetic nephropathy by oral administration of d-?-tocopherol and its mechanisms.
Diabetic Angiopathies
Diabetic vascular complications: pathophysiology, biochemical basis and potential therapeutic strategy.
Diabetic Angiopathies
Expression of genes related to the extracellular matrix in human endothelial cells. Differential modulation by elevated glucose concentrations, phorbol esters, and cAMP.
Diabetic Angiopathies
Glucose-induced TGF-beta1 and TGF-beta receptor-1 expression in vascular smooth muscle cells is mediated by protein kinase C-alpha.
Diabetic Angiopathies
Inhibition of Protein Kinase C ? Ameliorates Impaired Angiogenesis in Type I Diabetic Mice Complicating Myocardial Infarction.
Diabetic Angiopathies
NAD(P)H oxidase activation: a potential target mechanism for diabetic vascular complications, progressive beta-cell dysfunction and metabolic syndrome.
Diabetic Angiopathies
Pathophysiological role of Amadori-glycated proteins in diabetic microangiopathy.
Diabetic Angiopathies
Platelet protein kinase C isoform content in type 2 diabetes complicated with retinopathy and nephropathy.
Diabetic Angiopathies
Polymorphisms in the 5'-upstream region of the PKCbeta gene in Japanese patients with Type 2 diabetes.
Diabetic Angiopathies
Production of type IV collagen and 72-kDa gelatinase by human endothelial cells cultured in high glucose. Effects of a protein kinase C inhibitor, GF 109203X.
Diabetic Angiopathies
Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus.
Diabetic Angiopathies
Protein kinase C and the development of diabetic vascular complications.
Diabetic Angiopathies
Protein kinase C beta inhibition: A novel therapeutic strategy for diabetic microangiopathy.
Diabetic Angiopathies
Protein kinase C effects on nerve function, perfusion, Na(+), K(+)-ATPase activity and glutathione content in diabetic rats.
Diabetic Angiopathies
Protein kinase C-beta inhibition and diabetic microangiopathy: effects on endothelial permeability responses in vitro.
Diabetic Angiopathies
Role of nitrosative stress in the pathogenesis of diabetic vascular dysfunction.
Diabetic Angiopathies
The role of protein kinase C activation in the pathogenesis of diabetic vascular complications.
Diabetic Angiopathies
[Activity of membrane-bound protein kinase C and ATPase in erythrocytes in diabetic angiopathy]
Diabetic Angiopathies
[Progress on the drug therapy for diabetic microangiopathies: PKCbeta inhibitor]
Diabetic Cardiomyopathies
Breviscapine ameliorates cardiac dysfunction and regulates the myocardial Ca(2+)-cycling proteins in streptozotocin-induced diabetic rats.
Diabetic Cardiomyopathies
Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat.
Diabetic Cardiomyopathies
Coronary microvascular dysfunction in diabetes mellitus: A review.
Diabetic Cardiomyopathies
Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: Possible involvement of PKC-MAPK signaling pathway.
Diabetic Cardiomyopathies
Hyperglycemia-induced PKC?2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling.
Diabetic Cardiomyopathies
Identification of specific features of inhibition of PKC?II and its potential lead by shape-based virtual screening and molecular docking studies.
Diabetic Cardiomyopathies
Inactivation of 14-3-3 protein exacerbates cardiac hypertrophy and fibrosis through enhanced expression of protein kinase C beta 2 in experimental diabetes.
Diabetic Cardiomyopathies
Increased expression of Galphaq protein in the heart of streptozotocin-induced diabetic rats.
Diabetic Cardiomyopathies
Protein Kinases as Drug Development Targets for Heart Disease Therapy.
Diabetic Cardiomyopathies
Regulation of mitochondrial aconitase by phosphorylation in diabetic rat heart.
Diabetic Cardiomyopathies
Vascular endothelial dysfunction in diabetic cardiomyopathy: pathogenesis and potential treatment targets.
Diabetic Nephropathies
A central role for protein kinase C overactivity in diabetic glomerulosclerosis: implications for prevention with antioxidants, fish oil, and ACE inhibitors.
Diabetic Nephropathies
A high glucose concentration stimulates the expression of monocyte chemotactic peptide 1 in human mesangial cells.
Diabetic Nephropathies
A novel potential therapy for diabetic nephropathy and vascular complications: protein kinase C beta inhibition.
Diabetic Nephropathies
Activation of protein kinase c-delta and c-epsilon by oxidative stress in early diabetic rat kidney.
Diabetic Nephropathies
ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes.
Diabetic Nephropathies
Altered expression and subcellular localization of diacylglycerol-sensitive protein kinase C isoforms in diabetic rat glomerular cells.
Diabetic Nephropathies
Amelioration of diabetic nephropathy by oral administration of d-?-tocopherol and its mechanisms.
Diabetic Nephropathies
Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase C-alpha-dependent pathway.
Diabetic Nephropathies
Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model.
Diabetic Nephropathies
Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice.
Diabetic Nephropathies
Different expressions of protein kinase C-alpha, betaI and betaII in glomeruli of diabetic nephropathy patients.
Diabetic Nephropathies
Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-alpha-deficient diabetic mice.
Diabetic Nephropathies
Dual Inhibition of Classical Protein Kinase C-? and Protein Kinase C-? Isoforms Protects Against Experimental Murine Diabetic Nephropathy.
Diabetic Nephropathies
Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose.
Diabetic Nephropathies
Effect of telmisartan on expression of protein kinase C-alpha in kidneys of diabetic mice.
Diabetic Nephropathies
GLUT2 protein at the rat proximal tubule brush border membrane correlates with protein kinase C (PKC)-betal and plasma glucose concentration.
Diabetic Nephropathies
Glycated albumin stimulates TGF-beta 1 production and protein kinase C activity in glomerular endothelial cells.
Diabetic Nephropathies
Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats.
Diabetic Nephropathies
High expression of PKC-MAPK pathway mRNAs correlates with glomerular lesions in human diabetic nephropathy.
Diabetic Nephropathies
High glucose induces type 1 hexokinase gene expression in isolated glomeruli of diabetic rats and in mesangial cells.
Diabetic Nephropathies
High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly.
Diabetic Nephropathies
In situ protein Kinase C activity is increased in cultured fibroblasts from Type 1 diabetic patients with nephropathy.
Diabetic Nephropathies
Increased renal gene transcription of protein kinase C-beta in human diabetic nephropathy: relationship to long-term glycaemic control.
Diabetic Nephropathies
Influence of protein kinase C (PKC) on the prognosis of diabetic nephropathy patients.
Diabetic Nephropathies
Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway.
Diabetic Nephropathies
Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes.
Diabetic Nephropathies
Kidney outcomes in long-term studies of ruboxistaurin for diabetic eye disease.
Diabetic Nephropathies
Mesangial cell protein kinase C isozyme activation in the diabetic milieu.
Diabetic Nephropathies
Mitogen-activated protein kinase cascade is activated in glomeruli of diabetic rats and glomerular mesangial cells cultured under high glucose conditions.
Diabetic Nephropathies
Molecular mechanisms of diabetic nephropathy and its therapeutic intervention.
Diabetic Nephropathies
NADPH oxidase NOX1 is involved in activation of protein kinase C and premature senescence in early-stage diabetic kidney.
Diabetic Nephropathies
Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo.
Diabetic Nephropathies
No support for association of protein kinase C, beta 1 (PRKCB1) gene promoter polymorphisms c.-1504C>T and c.-546C>G with diabetic nephropathy in Type 1 diabetes.
Diabetic Nephropathies
Pathogenesis of diabetic nephropathy: the role of oxidative stress and protein kinase C.
Diabetic Nephropathies
PKC{alpha} Mediates {beta}-Arrestin2-dependent Nephrin Endocytosis in Hyperglycemia.
Diabetic Nephropathies
Podocytic PKC-alpha is regulated in murine and human diabetes and mediates nephrin endocytosis.
Diabetic Nephropathies
Protein kinase C beta (PRKCB1) and pigment epithelium derived factor (PEDF) gene polymorphisms and diabetic retinopathy in a south Indian cohort.
Diabetic Nephropathies
Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension.
Diabetic Nephropathies
Protein kinase C beta inhibition: the promise for treatment of diabetic nephropathy.
Diabetic Nephropathies
Protein kinase C beta inhibitors: a new therapeutic target for diabetic nephropathy and vascular complications.
Diabetic Nephropathies
Protein kinase C ß inhibition ameliorates experimental mesangial proliferative glomerulonephritis.
Diabetic Nephropathies
Protein kinase C-{beta} inhibition attenuates the progression of nephropathy in non-diabetic kidney disease.
Diabetic Nephropathies
Role of protein kinase C in podocytes and development of glomerular damage in diabetic nephropathy.
Diabetic Nephropathies
Sodium-Glucose Cotransporter 2 Inhibitors with Renoprotective Effects.
Diabetic Nephropathies
The mechanisms of ameliorating effect of a green tea polyphenol on diabetic nephropathy based on diacylglycerol kinase ?.
Diabetic Nephropathies
Therapeutic strategies in the treatment of diabetic nephropathy - a translational medicine approach.
Diabetic Nephropathies
Whole-Genome Sequencing of Finnish Type 1 Diabetic Siblings Discordant for Kidney Disease Reveals DNA Variants associated with Diabetic Nephropathy.
Diabetic Nephropathies
[Effect of tangshen formula on phospholipids metabolism in diabetic nephropathy patients].
Diabetic Nephropathies
[Nephrotic syndrome due to metabolic disease--special reference to diabetic nephropathy]
Diabetic Nephropathies
[Protein kinase C-betaI, betaII in mouse diabetic nephropathy kidney and its relation to nephroprotective actions of the angiotensin receptor blocker telmistartan]
Diabetic Nephropathies
[The role of cellular glucose transporters in pathogenesis of diabetic nephropathy]
Diabetic Neuropathies
Altered sorbitol and myo-inositol metabolism as the basis for defective protein kinase C and (Na,K)-ATPase regulation in diabetic neuropathy.
Diabetic Neuropathies
Clinical implications of basic neuroscience research. I: Protein kinases, ionic channels, and genes.
Diabetic Neuropathies
Continuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy.
Diabetic Neuropathies
Deciphering the Neuroprotective Role of Glucagon-like Peptide-1 Agonists in Diabetic Neuropathy: Current Perspective and Future Directions.
Diabetic Neuropathies
Diabetic neuropathy: inhibitory G protein dysfunction involves PKC-dependent phosphorylation of Goalpha.
Diabetic Neuropathies
Diabetic Neuropathy: Update on Pathophysiological Mechanism and the Possible Involvement of Glutamate Pathways.
Diabetic Neuropathies
Diabetic peripheral neuropathy: current perspective and future directions.
Diabetic Neuropathies
Effects of the protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes.
Diabetic Neuropathies
Erythropoietin: A potential drug in the management of diabetic neuropathy.
Diabetic Neuropathies
Methylcobalamin effects on diabetic neuropathy and nerve protein kinase C in rats.
Diabetic Neuropathies
Pathophysiology and treatment of diabetic peripheral neuropathy: the case for diabetic neurovascular function as an essential component.
Diabetic Neuropathies
Polyol pathway and protein kinase C activity of rat Schwannoma cells.
Diabetic Neuropathies
Protein kinase C beta inhibition and aorta and corpus cavernosum function in streptozotocin-diabetic mice.
Diabetic Neuropathies
Protein kinase C effects on nerve function, perfusion, Na(+), K(+)-ATPase activity and glutathione content in diabetic rats.
Diabetic Neuropathies
Protein kinase C isozyme expression in sciatic nerves and spinal cords of experimentally diabetic rats.
Diabetic Neuropathies
Real-Time Translocation and Function of PKC?II Isoform in Response to Nociceptive Signaling via the TRPV1 Pain Receptor.
Diabetic Neuropathies
Role of Oxidative Stress and Ca(2+) Signaling on Molecular Pathways of Neuropathic Pain in Diabetes: Focus on TRP Channels.
Diabetic Retinopathy
A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats.
Diabetic Retinopathy
Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.
Diabetic Retinopathy
Advanced glycation end products increase, through a protein kinase C-dependent pathway, vascular endothelial growth factor expression in retinal endothelial cells. Inhibitory effect of gliclazide.
Diabetic Retinopathy
Computational investigation of pkc? inhibitors for the treatment of diabetic retinopathy.
Diabetic Retinopathy
Current and future pharmacological intervention for diabetic retinopathy.
Diabetic Retinopathy
Diabetic macular oedema and visual loss: relationship to location, severity and duration.
Diabetic Retinopathy
Diabetic retinopathy: current developments in pathogenesis and management.
Diabetic Retinopathy
Dose- and time-dependent pharmacokinetics of midostaurin in patients with diabetes mellitus.
Diabetic Retinopathy
EFFECT OF RUBOXISTAURIN (RBX) ON VISUAL ACUITY DECLINE OVER A 6-YEAR PERIOD WITH CESSATION AND REINSTITUTION OF THERAPY: Results of an Open-Label Extension of the Protein Kinase C Diabetic Retinopathy Study 2 (PKC-DRS2).
Diabetic Retinopathy
Effects on protein kinase C-beta inhibition on glomerular vascular endothelial growth factor expression and endothelial cells in advanced experimental diabetic nephropathy.
Diabetic Retinopathy
Emerging therapies for the treatment of neovascular age-related macular degeneration and diabetic macular edema.
Diabetic Retinopathy
Endothelin-1 and protein kinase C co-expression in the pathogenesis of diabetic retinopathy.
Diabetic Retinopathy
Growth factors and protein kinase C inhibitors as novel therapies for the medical management diabetic retinopathy.
Diabetic Retinopathy
IGFBP-3 reduces eNOS and PKCzeta phosphorylation, leading to lowered VEGF levels.
Diabetic Retinopathy
Increased platelet aggregation in diabetic patients with microangiopathy despite good glycemic control.
Diabetic Retinopathy
Inhibition of protein kinase C delta attenuates blood-retinal barrier breakdown in diabetic retinopathy.
Diabetic Retinopathy
Inhibition of protein kinase C might be harmful to diabetic retinopathy.
Diabetic Retinopathy
Mechanisms for monitoring changes in retinal status following therapeutic intervention in diabetic retinopathy.
Diabetic Retinopathy
ORAL PROTEIN KINASE C ? INHIBITION USING RUBOXISTAURIN: Efficacy, Safety, and Causes of Vision Loss Among 813 Patients (1,392 Eyes) with Diabetic Retinopathy in the Protein Kinase C ? Inhibitor-Diabetic Retinopathy Study and the Protein kinase C ? Inhibitor-Diabetic Retinopathy Study 2.
Diabetic Retinopathy
Potential new medical therapies for diabetic retinopathy: protein kinase C inhibitors.
Diabetic Retinopathy
Protein kinase C and the development of diabetic vascular complications.
Diabetic Retinopathy
Protein kinase C beta (PRKCB1) and pigment epithelium derived factor (PEDF) gene polymorphisms and diabetic retinopathy in a south Indian cohort.
Diabetic Retinopathy
Protein kinase C beta2-dependent phosphorylation of core 2 GlcNAc-T promotes leukocyte-endothelial cell adhesion: a mechanism underlying capillary occlusion in diabetic retinopathy.
Diabetic Retinopathy
Protein kinase C expression in the rabbit retina after laser photocoagulation.
Diabetic Retinopathy
Protein kinase C inhibition and diabetic retinopathy: a shot in the dark at translational research.
Diabetic Retinopathy
Protein Kinase C Inhibitors in the Treatment of Diabetic Retinopathy. Review.
Diabetic Retinopathy
Relationship between aldose reductase enzyme and the signaling pathway of protein kinase C in the in vitro diabetic retinopathy model.
Diabetic Retinopathy
Role of protein kinase C on the alteration of retinal endothelin-1 in streptozotocin-induced diabetic rats.
Diabetic Retinopathy
Suppression of protein kinase C-? attenuates vascular leakage via prevention of tight junction protein decrease in diabetic retinopathy.
Diabetic Retinopathy
Targeting the retinal microcirculation to treat diabetic sight problems.
Diabetic Retinopathy
The anti-ALS drug riluzole attenuates pericyte loss in the diabetic retinopathy of streptozotocin-treated mice.
Diabetic Retinopathy
The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical trial.
Diabetic Retinopathy
The Oxidative Stress and Mitochondrial Dysfunction during the Pathogenesis of Diabetic Retinopathy.
Diabetic Retinopathy
The role of lipids and protein kinase Cs in the pathogenesis of diabetic retinopathy.
Diabetic Retinopathy
Tonicity-responsive enhancer binding protein regulates the expression of aldose reductase and protein kinase C ? in a mouse model of diabetic retinopathy.
Diabetic Retinopathy
Treatment of diabetic retinopathy with protein kinase C subtype Beta inhibitor.
Diabetic Retinopathy
[The changes of histology and biochemical parameters in retina of the patient with diabetic retinopathy]
Diabetic Retinopathy
[The role of protein kinase C in the pathophysiology of diabetic retinopathy]
Diphtheria
Phosphorylation, desensitization and internalization of human alpha1B-adrenoceptors induced by insulin-like growth factor-I.
Distemper
Phosphorylation of canine distemper virus P protein by protein kinase C-zeta and casein kinase II.
Donohue Syndrome
Epidermal growth factor receptor defects in leprechaunism. A multiple growth factor-resistant syndrome.
Down Syndrome
Alzheimer's disease skin fibroblasts selectively express a bradykinin signaling pathway mediating tau protein Ser phosphorylation.
Down Syndrome
Fibroblasts of patients affected by Down's syndrome oversecrete amyloid precursor protein and are hyporesponsive to protein kinase C stimulation.
Drug-Related Side Effects and Adverse Reactions
A Comprehensive Review of Erectile Dysfunction in Men with Diabetes.
Dry Eye Syndromes
Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion.
Duodenal Neoplasms
Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells.
Dysarthria
Spinocerebellar ataxia 14: novel mutation in exon 2 of PRKCG in a German family.
Dyslipidemias
Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells.
Echovirus Infections
Cell susceptibility to baculovirus transduction and echovirus infection is modified by protein kinase C phosphorylation and vimentin organization.
Eclampsia
Platelets from eclampsia patients have reduced membrane microviscosity and lower activities of the signalling enzymes.
Encephalomyelitis
Protein kinase C gamma (PKC?) as a novel marker to assess the functional status of the corticospinal tract in experimental autoimmune encephalomyelitis (EAE).
Encephalomyelitis
Resistance to Experimental Autoimmune Encephalomyelitis and Impaired IL-17 Production in Protein Kinase C{theta}-Deficient Mice.
Encephalomyelitis, Autoimmune, Experimental
PKCtheta: A potential therapeutic target for T-cell-mediated diseases.
Encephalomyelitis, Autoimmune, Experimental
Protein kinase C gamma (PKC?) as a novel marker to assess the functional status of the corticospinal tract in experimental autoimmune encephalomyelitis (EAE).
Encephalomyelitis, Autoimmune, Experimental
Resistance to Experimental Autoimmune Encephalomyelitis and Impaired IL-17 Production in Protein Kinase C{theta}-Deficient Mice.
Encephalomyelitis, Venezuelan Equine
Protein Kinase C subtype ? interacts with Venezuelan equine encephalitis virus capsid protein and regulates viral RNA binding through modulation of capsid phosphorylation.
Endometrial Neoplasms
Analysis of protein kinase C delta (PKC delta) expression in endometrial tumors.
Endometrial Neoplasms
c-Jun N-terminal kinase regulates apoptosis in endometrial cancer cells.
Endometrial Neoplasms
cAMP and PMA enhance the effects of IGF-I in the proliferation of endometrial adenocarcinoma cell line HEC-1-A by acting at the G1 phase of the cell cycle.
Endometrial Neoplasms
Cisplatin increases B-cell-lymphoma-2 expression via activation of protein kinase C and Akt2 in endometrial cancer cells.
Endometrial Neoplasms
Clinical implication of fos and jun expressions and protein kinase activity in endometrial cancers.
Endometrial Neoplasms
Endometrial cancer cell survival and apoptosis is regulated by protein kinase C alpha and delta.
Endometrial Neoplasms
Epidermal growth factor activates protein kinase C in the human endometrial cancer cell line HEC-1-A.
Endometrial Neoplasms
Estrogen induces expression of c-fos and c-jun via activation of protein kinase C in an endometrial cancer cell line and fibroblasts derived from human uterine endometrium.
Endometrial Neoplasms
Luteinizing hormone-releasing hormone agonist triptorelin antagonizes signal transduction and mitogenic activity of epidermal growth factor in human ovarian and endometrial cancer cell lines.
Endometrial Neoplasms
Membrane ERalpha-dependent activation of PKCalpha in endometrial cancer cells by estradiol.
Endometrial Neoplasms
Phorbol esters differentially regulate the expression of insulin-like growth factor-binding proteins in endometrial carcinoma cells.
Endometrial Neoplasms
Protein Kinase C ? Modulates Estrogen-Receptor-Dependent Transcription and Proliferation in Endometrial Cancer Cells.
Endometrial Neoplasms
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
Endometrial Neoplasms
Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer.
Endometrial Neoplasms
Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis.
Endometrial Neoplasms
Protein kinase C-independent stimulation of activator protein-1 and c-Jun N-terminal kinase activity in human endometrial cancer cells by the LHRH agonist triptorelin.
Endometrial Neoplasms
X-linked inhibitor of apoptosis protein levels and protein kinase C activity regulate the sensitivity of human endometrial carcinoma cells to tumor necrosis factor alpha-induced apoptosis.
Endometrial Neoplasms
[Effect of phorbol ester on tissue-type plasminogen activator (t-PA) secretion in endometrial carcinoma cell line in vitro]
Endometriosis
Differential expression of genes in eutopic and ectopic endometrium from patients with ovarian endometriosis.
Endometriosis
DNA microarray analysis of gene expression profiles in deep endometriosis using laser capture microdissection.
Endometriosis
Effects of a protein kinase C inhibitor on the initial development of ectopic implants in a syngeneic mouse model of endometriosis.
Endometriosis
Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice.
Endotoxemia
Alterations in splenic and hepatic protein kinase C in sepsis and chronic endotoxemia.
Endotoxemia
Modification of protein kinase C (PKC) activity and diacylglycerol (DAG) accumulation in hepatocytes in continuous endotoxemia.
Endotoxemia
Protein kinase C delta (PKC?)-extracellular-signal regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia.
Endotoxemia
[Alterations of protein kinase C activity in rat myocardium and aorta smooth muscle during endotoxemia]
Enzootic Bovine Leukosis
Inhibition of protein kinase C results in decreased expression of bovine leukemia virus.
Epilepsies, Partial
Protein kinase C activity and intracellular distribution in surgically excised human epileptic neocortex.
Epilepsy
A hydrogen sulfide donor suppresses pentylenetetrazol-induced seizures in rats via PKC signaling.
Epilepsy
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts.
Epilepsy
Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases.
Epilepsy
PICK1facilitates lasting reduction in GluA2 concentration In the hippocampus during chronic epilepsy.
Epilepsy
Role of protein kinase C in modulation of excitability of CA1 pyramidal neurons in the rat.
Epilepsy
Supersensitivity to allosteric GABA(A) receptor modulators and alcohol in mice lacking PKCepsilon.
Epstein-Barr Virus Infections
Cordycepin enhances Epstein-Barr virus lytic infection and Epstein-Barr virus-positive tumor treatment efficacy by doxorubicin.
Epstein-Barr Virus Infections
Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors.
Epstein-Barr Virus Infections
Protein Kinase C-Delta Defect in Autoimmune Lymphoproliferative Syndrome-Like Disease: First Case from the National Iranian Registry and Review of the Literature.
Erectile Dysfunction
Altered penile vascular reactivity and erection in the Zucker obese-diabetic rat.
Erectile Dysfunction
Enhanced thromboxane receptor-mediated responses and impaired endothelium-dependent relaxation in human corpus cavernosum from diabetic impotent men: role of protein kinase C activity.
Erythema
Attenuation of ultraviolet radiation-induced edema and erythema with topical calmodulin and protein kinase C inhibitors.
Escherichia coli Infections
Externalization of host cell protein kinase C during enteropathogenic Escherichia coli infection.
Esophageal Neoplasms
Induction of apoptosis of lung and esophageal cancer cells treated with the combination of histone deacetylase inhibitor (trichostatin A) and protein kinase C inhibitor (calphostin C).
Esophageal Neoplasms
Phase II trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer.
Esophageal Neoplasms
Phorbol 12,13 dibutyrate behaves in a tumor-inhibitory manner in esophageal adenocarcinoma cell lines.
Esophageal Squamous Cell Carcinoma
PKC iota promotes cellular proliferation by accelerated G1/S transition via interaction with CDK7 in esophageal squamous cell carcinoma.
Esophagitis
Experimental esophagitis affects intracellular calcium stores in the cat lower esophageal sphincter.
Essential Hypertension
Activity of protein kinase C in erythrocytes in primary hypertension.
Essential Hypertension
Cytosolic Ca2+, Na+/H+ antiport, protein kinase C trio in essential hypertension.
Essential Hypertension
Effect of protein kinase C activation on cytoskeleton and cation transport in human erythrocytes. Reproduction of some membrane abnormalities revealed in essential hypertension.
Essential Hypertension
Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide.
Essential Hypertension
Protein kinase C activity in erythrocytes in primary hypertension: regulation of cell shape and cation transport.
Essential Hypertension
The roles of cell Ca2+, protein kinase C and the Na(+)-H+ antiport in the development of hypertension and insulin resistance.
Essential Hypertension
[Protein kinase A and C activity of erythrocytes in patients with essential hypertension]
Essential Hypertension
[Red cell Na+/H+ exchange and role of protein kinase C in its stimulation in diabetes mellitus, essential hypertension and nephropathy]
Eye Diseases
Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidines as atypical protein kinase C inhibitors to control retinal vascular permeability and cytokine-induced edema.
Fasciculation
Defasciculation of neurites is mediated by tenascin-R and its neuronal receptor F3/11.
Fasciculation
Ectopic growth of hippocampal mossy fibers in a mutated GAP-43 transgenic mouse with impaired spatial memory retention.
Fasciculation
Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1.
Fasciculation
Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein.
Fasciculation
NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube.
Fatty Liver
Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous hepatocarcinogenesis in choline-deficient rats.
Fatty Liver
Dietary fish oil attenuates cardiac hypertrophy in lipotoxic cardiomyopathy due to systemic carnitine deficiency.
Fatty Liver
Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain.
Fatty Liver
High fat diet-induced oxidative stress blocks hepatocyte nuclear factor 4? and leads to hepatic steatosis in mice.
Fatty Liver
Lipid metabolism, oxidative stress and cell death are regulated by PKC delta in a dietary model of nonalcoholic steatohepatitis.
Fatty Liver
Protein kinase C (PKC) delta is activated in a dietary model of steatohepatitis and regulates endoplasmic reticulum stress and cell death.
Fatty Liver
Reduced protein kinase C activity and endogenous protein phosphorylation in ethionine-induced fatty liver in cows.
Fatty Liver
The interplay of canonical and noncanonical Wnt signaling in metabolic syndrome.
Fatty Liver
[Mechanism of expression of the Src family kinases (Fgr, Hck, Lyn) and SSeCKS in non-alcoholic steatohepatitis].
Fatty Liver, Alcoholic
Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosis.
Fetal Diseases
Demonstration of the essential role of protein kinase C isoforms in hyperglycemia-induced embryonic malformations.
Fetal Diseases
Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy.
Fetal Diseases
N-Acetylcysteine and alpha-cyano-4-hydroxycinnamic acid alter protein kinase C (PKC)-delta and PKC-zeta and diminish dysmorphogenesis in rat embryos cultured with high glucose in vitro.
Fetal Diseases
Protein kinase C?2 inhibition reduces hyperglycemia-induced neural tube defects through suppression of a caspase 8-triggered apoptotic pathway.
Fetal Hypoxia
Chronic prenatal hypoxia induces epigenetic programming of PKC{epsilon} gene repression in rat hearts.
Fetal Nutrition Disorders
Fetal malnutrition is associated with impairment of endogenous melatonin synthesis in pineal via hypermethylation of promoters of protein kinase C alpha and cAMP response element-binding.
Fibromatosis, Aggressive
Suppression of protein kinase C and the stimulation of glucocorticoid receptor synthesis by dexamethasone in human fibroblasts derived from tumor tissue.
Fibromyalgia
Altered interleukin-2 secretion in patients with primary fibromyalgia syndrome.
Fibrosarcoma
A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to adriamycin.
Fibrosarcoma
Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta.
Fibrosarcoma
Autocrine motility factor signaling induces tumor apoptotic resistance by regulations Apaf-1 and Caspase-9 apoptosome expression.
Fibrosarcoma
Distinct patterns of phorbol ester-induced downregulation of protein kinase C activity in adriamycin-selected multidrug resistant and parental murine fibrosarcoma cells.
Fibrosarcoma
Effect of protein kinase C activating tumor promoters on metastases formation by fibrosarcoma cells.
Fibrosarcoma
Failure of wild-type or a mutant form of protein kinase C-alpha to transform fibroblasts.
Fibrosarcoma
Level of protein kinase C activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells.
Fibrosarcoma
Microgravity-Induced Transcriptome Adaptation in Mouse Paraspinal longissimus dorsi Muscle Highlights Insulin Resistance-Linked Genes.
Fibrosarcoma
Phospholipase D mediates matrix metalloproteinase-9 secretion in phorbol ester-stimulated human fibrosarcoma cells.
Fibrosarcoma
Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase.
Fibrosarcoma
Protein kinase C isoforms involved in regulation of cell shape and locomotion of human fibrosarcoma HT1080 cells.
Fibrosarcoma
Site-dependent differences in response of the UV-2237 murine fibrosarcoma to systemic therapy with adriamycin.
Fibrosarcoma
Systems Biology Strategy Reveals PKC? is Key for Sensitizing TRAIL-Resistant Human Fibrosarcoma.
Fibrosarcoma
The effect of UCN-01 (7-hydroxystaurosporine), a potent inhibitor of protein kinase C, on fractionated radiotherapy or daily chemotherapy of a murine fibrosarcoma.
Fibrosarcoma
The eta isoform of protein kinase C mediates transcriptional activation of the human transglutaminase 1 gene.
Fibrosarcoma
[An experimental study on the capability of laminin receptor antibody and protein kinase C inhibitor to inhibit tumor metastasis in vivo]
Fragile X Syndrome
Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson's disease.
Frontotemporal Lobar Degeneration
Phosphoproteomic Analysis Reveals Site-Specific Changes in GFAP and NDRG2 Phosphorylation in Frontotemporal Lobar Degeneration.
Frontotemporal Lobar Degeneration
The olfactory bulb proteotype differs across frontotemporal dementia spectrum.
Gait Ataxia
Spinocerebellar ataxia 14: novel mutation in exon 2 of PRKCG in a German family.
Galactosemias
Abnormalities of retinal metabolism in diabetes or experimental galactosemia: V. Relationship between protein kinase C and ATPases.
Gallstones
Protein kinase C-alpha regulation of gallbladder Na+ transport becomes progressively more dysfunctional during gallstone formation.
Ganglioglioma
Array analysis of epilepsy-associated gangliogliomas reveals expression patterns related to aberrant development of neuronal precursors.
Ganglion Cysts
Activation of the RAS/B-RAF-MEK-ERK pathway in satellite glial cells contributes to substance p-mediated orofacial pain.
Ganglion Cysts
Protein kinase C activation in Aplysia neurons by phorbol diacetate: comparison of effects following extracellular or intracellular application.
Ganglion Cysts
Tamoxifen suppresses paclitaxel-, vincristine-, and bortezomib-induced neuropathy via inhibition of the protein kinase C/extracellular signal-regulated kinase pathway.
Gardner Syndrome
Suppression of protein kinase C and the stimulation of glucocorticoid receptor synthesis by dexamethasone in human fibroblasts derived from tumor tissue.
Gastrointestinal Neoplasms
Dihydroxy bile acids activate the transcription of cyclooxygenase-2.
Gastrointestinal Neoplasms
Levels of protein kinase C activity in human gastrointestinal cancers.
Gastrointestinal Stromal Tumors
Characteristics of KIT-negative gastrointestinal stromal tumours and diagnostic utility of protein kinase C theta immunostaining.
Gastrointestinal Stromal Tumors
Clinicopathological and immunohistochemical features of gastointestinal stromal tumors.
Gastrointestinal Stromal Tumors
Gastrointestinal stromal tumor markers in cutaneous melanomas: relationship to prognostic factors and outcome.
Gastrointestinal Stromal Tumors
PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumors (GIST), especially useful for identifying KIT-negative tumors.
Gastrointestinal Stromal Tumors
Protein Kinase C theta (PKCtheta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs).
Gastrointestinal Stromal Tumors
Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias.
Gastrointestinal Stromal Tumors
Specificity of DOG1 (K9 clone) and protein kinase C theta (clone 27) as immunohistochemical markers of gastrointestinal stromal tumour.
Gaucher Disease
Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses.
Genetic Diseases, Inborn
Loss of protein kinase Cgamma in knockout mice and increased retinal sensitivity to hyperbaric oxygen.
Gestational Trophoblastic Disease
p-21-Activated kinase-1, -4 and -6 and estrogen receptor expression pattern in normal placenta and gestational trophoblastic diseases.
Giant Cell Tumor of Bone
Translocation of protein kinase C isoenzymes by elevated extracellular Ca2+ concentration in cells from a human giant cell tumor of bone.
Giant Cell Tumors
Translocation of protein kinase C isoenzymes by elevated extracellular Ca2+ concentration in cells from a human giant cell tumor of bone.
Glaucoma
Intra-Cellular Calcium Signaling Pathways (PKC, RAS/RAF/MAPK, PI3K) in Lamina Cribrosa Cells in Glaucoma.
Glaucoma
The role of PKCzeta in NMDA-induced retinal ganglion cell death: prevention by aspirin.
Glioblastoma
?-3 and ?-6 Fatty Acids Modulate Conventional and Atypical Protein Kinase C Activities in a Brain Fatty Acid Binding Protein Dependent Manner in Glioblastoma Multiforme.
Glioblastoma
Acridine Yellow G Blocks Glioblastoma Growth via Dual Inhibition of Epidermal Growth Factor Receptor and Protein Kinase C Kinases.
Glioblastoma
ADAM-10-mediated N-cadherin cleavage is protein kinase C-alpha dependent and promotes glioblastoma cell migration.
Glioblastoma
Antisense expression of protein kinase C alpha inhibits the growth and tumorigenicity of human glioblastoma cells.
Glioblastoma
Chemoradiotherapy in malignant glioma: standard of care and future directions.
Glioblastoma
Contribution of protein kinase C to p53-dependent WAF1 induction pathway after heat treatment in human glioblastoma cell lines.
Glioblastoma
Control of the expression of c-sis mRNA in human glioblastoma cells by phorbol ester and transforming growth factor beta 1.
Glioblastoma
Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy.
Glioblastoma
Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas.
Glioblastoma
Expression pattern of alpha-protein kinase C in human astrocytomas indicates a role in malignant progression.
Glioblastoma
Galectin-1 Is Implicated in the Protein Kinase C epsilon/Vimentin-Controlled Trafficking of Integrin-beta1 in Glioblastoma Cells.
Glioblastoma
Induction of apoptosis in glioblastoma cells by an atypical protein kinase C pseudosubstrate peptide.
Glioblastoma
Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3.
Glioblastoma
Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Calpha antisense oligonucleotide.
Glioblastoma
Influence of Pi3-K and PKC activity on 99mTc-(V)-DMSA uptake: correlation with tumour aggressiveness in an in vitro malignant glioblastoma cell line model.
Glioblastoma
Inhibition of the growth of glioblastomas by CGP 41251, an inhibitor of protein kinase C, and by a phorbol ester tumor promoter.
Glioblastoma
Meta-analysis of oncogenic protein kinase Ciota signaling in lung adenocarcinoma.
Glioblastoma
Modulation of the human protein kinase C alpha gene promoter by activator protein-2.
Glioblastoma
Nuclear import mechanism of neurofibromin for localization on the spindle and function in chromosome congression.
Glioblastoma
Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples.
Glioblastoma
Phorbol 12-myristate 13-acetate (PMA)-induced migration of glioblastoma cells is mediated via p38MAPK/Hsp27 pathway.
Glioblastoma
Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells.
Glioblastoma
PKC alpha phosphorylates cytosolic NF-kappaB/p65 and PKC delta delays nuclear translocation of NF-kappaB/p65 in U1242 glioblastoma cells.
Glioblastoma
PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival.
Glioblastoma
PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways.
Glioblastoma
Protection of glioblastoma cells from cisplatin cytotoxicity via protein kinase Ciota-mediated attenuation of p38 MAP kinase signaling.
Glioblastoma
Protein kinase C activation by phorbol ester increases in vitro invasion through regulation of matrix metalloproteinases/tissue inhibitors of metalloproteinases system in D54 human glioblastoma cells.
Glioblastoma
Protein kinase C delta is a prosurvival factor in human breast tumor cell lines.
Glioblastoma
Protein kinase C zeta isoform is critical for proliferation in human glioblastoma cell lines.
Glioblastoma
Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation.
Glioblastoma
Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation.
Glioblastoma
PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1.
Glioblastoma
Rac1 mediates phorbol 12-myristate 13-acetate-induced migration of glioblastoma cells via paxillin.
Glioblastoma
Reduction of protein kinase C zeta inhibits migration and invasion of human glioblastoma cells.
Glioblastoma
Regulation of Cdk7 activity through a phosphatidylinositol (3)-kinase/PKC-?-mediated signaling cascade in glioblastoma.
Glioblastoma
Rehmannia glutinosa induces glial cell line-derived neurotrophic factor gene expression in astroglial cells via cPKC and ERK1/2 pathways independently.
Glioblastoma
Role of protein kinase C activation in synthesis of complement components C2 and factor B in interferon-gamma-stimulated human fibroblasts, glioblastoma cell line A172 and monocytes.
Glioblastoma
Role of protein kinase C isoforms in phorbol ester-induced vascular endothelial growth factor expression in human glioblastoma cells
Glioblastoma
Role of protein kinase C isoforms in phorbol ester-induced vascular endothelial growth factor expression in human glioblastoma cells.
Glioblastoma
Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies.
Glioblastoma
Src regulates phorbol 12-myristate 13-acetate-activated PKC-induced migration via Cas/Crk/Rac1 signaling pathway in glioblastoma cells.
Glioblastoma
Tamoxifen inhibits particulate-associated protein kinase C activity, and sensitises cultured human glioblastoma cells not to etoposide but to gamma-radiation and BCNU.
Glioblastoma
Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNF? in glioblastoma.
Glioblastoma
Targeting atypical protein kinase C iota reduces viability in glioblastoma stem-like cells via a notch signaling mechanism.
Glioblastoma
The Curcumin Analog C-150, Influencing NF-?B, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo.
Glioblastoma
The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells.
Glioblastoma
The identification of four protein kinase C isoforms in human glioblastoma cell lines: PKC alpha, gamma, epsilon, and zeta.
Glioblastoma
The involvement of protein kinase C isoenzymes alpha, epsilon and zeta in the sensitivity to antitumor treatment and apoptosis induction.
Glioblastoma
The protein kinase C-eta isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway.
Glioblastoma
The role of protein kinase C-alpha in malignancies of the nervous system and implications for the clinical development of the specific PKC-alpha inhibitor aprinocarsen (Review).
Glioblastoma
Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C-alpha phosphorothioate oligodeoxynucleotide.
Glioma
A major myristylated substrate of protein kinase C and protein kinase C itself are differentially regulated during murine B- and T-lymphocyte development and activation.
Glioma
A phase I study of high-dose tamoxifen for the treatment of refractory malignant gliomas of childhood.
Glioma
A protective role of PKCepsilon against TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in glioma cells.
Glioma
A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle.
Glioma
Activation of a K+ conductance by bradykinin and by inositol-1,4,5-trisphosphate in rat glioma cells: involvement of intracellular and extracellular Ca2+.
Glioma
Activation of phospholipase D by platelet-derived growth factor (PDGF) in rat C6 glioma cells: possible role in mitogenic signal transduction.
Glioma
Activation of stress-activated protein kinase/c-Jun NH2-terminal kinase and p38 kinase in calphostin C-induced apoptosis requires caspase-3-like proteases but is dispensable for cell death.
Glioma
Activity of protein kinase C is necessary for sustained thrombin-induced [Ca2+]i oscillations in rat glioma cells.
Glioma
Agonist-induced desensitization of ATP receptor-mediated phosphoinositide turnover in C6 glioma cells: comparison with the negative-feedback regulation by protein kinase C.
Glioma
Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells.
Glioma
Antisense Oligodeoxynucleotide Technology: Potential Use for the Treatment of Malignant Brain Tumors.
Glioma
Apoptosis is induced in glioma cells by antisense oligonucleotides to protein kinase C alpha and is enhanced by cycloheximide.
Glioma
Apoptosis of human glioma cells in response to calphostin C, a specific protein kinase C inhibitor.
Glioma
Atypical PKCzeta is involved in RhoA-dependent mitogenic signaling by the P2Y(12) receptor in C6 cells.
Glioma
Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide.
Glioma
Blocking of glioma proliferation in vitro and in vivo and potentiating the effects of BCNU and cisplatin: UCN-01, a selective protein kinase C inhibitor.
Glioma
Ca2+ inhibition of beta-adrenergic receptor- and forskolin-stimulated cAMP accumulation in C6-2B rat glioma cells is independent of protein kinase C.
Glioma
Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.
Glioma
Changes in Ca2+ concentration in phorbol ester and thapsigargin treated glioma C6 cells. The role of protein kinase C in regulation of Ca2+ entry.
Glioma
Changes in protein kinase C epsilon phosphorylation status and intracellular localization as 3T3 and 3T6 fibroblasts grow to confluency and quiescence: a role for phosphorylation at ser-729?
Glioma
Changes of Src-suppressed C kinase substrate expression in cytokine induced reactive C6 glioma cells.
Glioma
Characterization of taurine transport in human glioma GL15 cell line: regulation by protein kinase C.
Glioma
Characterization of the interaction of hypericin with protein kinase C in U-87 MG human glioma cells.
Glioma
Chloroquine induces the expression of inducible nitric oxide synthase in C6 glioma cells.
Glioma
Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen.
Glioma
Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells.
Glioma
Combination of endostatin and a protein kinase Calpha DNA enzyme improves the survival of rats with malignant glioma.
Glioma
Combination therapy with irinotecan and protein kinase C inhibitors in malignant glioma.
Glioma
Concanavalin A prevents phorbol-mediated redistribution of protein kinase C and beta-adrenergic receptors in rat glioma C6 cells.
Glioma
Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor.
Glioma
Differential activation of ERKs to focal adhesions by PKC epsilon is required for PMA-induced adhesion and migration of human glioma cells.
Glioma
Differential correlation between translocation and down-regulation of conventional and new protein kinase C isozymes in C6 glioma cells.
Glioma
Differential effects of 12-O-tetradecanoyl-13-phorbol acetate (TPA) on growth, migration and invasion of a human glioma cell line.
Glioma
Differential expression of MARCKS and other calmodulin-binding protein kinase C substrates in cultured neuroblastoma and glioma cells.
Glioma
Differential expression of protein kinase C isoforms in glial and neuronal cells. Translocation and down-regulation of PKC isoforms in C6 glioma and NG 108-15 hybrid cells: effects of extracellular Ca(2+)-depletion.
Glioma
Differential expression of protein kinase C subtypes during ginsenoside Rh2-lnduced apoptosis in SK-N-BE(2) and C6Bu-1 cells.
Glioma
Differential induction of cell death in human glioma cell lines by sodium nitroprusside.
Glioma
Differential nuclear localization of protein kinase C isoforms in neuroblastoma x glioma hybrid cells.
Glioma
Differential role for protein kinase C-mediated signaling in the proliferation of medulloblastoma cell lines.
Glioma
Disparity in expression of protein kinase C alpha in human glioma versus glioma-derived primary cell lines: therapeutic implications.
Glioma
Dissociation of phosphorylation and translocation of a myristoylated protein kinase C substrate (MARCKS protein) in C6 glioma and N1E-115 neuroblastoma cells.
Glioma
Down-regulation of protein kinase C in rat glioma C6 cells: effects on the beta-adrenergic receptor-coupled adenylate cyclase.
Glioma
Effect of tamoxifen on DNA synthesis and proliferation of human malignant glioma lines in vitro.
Glioma
Effects of an inhibitor of protein kinases on the response to heat treatment in cultured mammalian cells.
Glioma
Effects of Ca2+ on the activation of conventional and new PKC isozymes and on TPA and endothelin-1 induced translocations of these isozymes in intact cells.
Glioma
Effects of insulin on protein phosphorylation and protein kinase C activity in human malignant gliomas.
Glioma
Effects of interferon and PKC modulators on human glioma protein kinase C, cell proliferation, and cell cycle.
Glioma
Effects of protein kinase C modulators on multidrug resistance in human glioma cells.
Glioma
Effects of the PKC inhibitor PD 406976 on cell cycle progression, proliferation, PKC isozymes and apoptosis in glioma and SVG-transformed glial cells.
Glioma
Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas.
Glioma
EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells.
Glioma
Endothelin receptors stimulate both phospholipase C and phospholipase D activities in different cell lines.
Glioma
Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro.
Glioma
Enzastaurin renders MCF-7 breast cancer cells sensitive to radiation through reversal of radiation-induced activation of protein kinase C.
Glioma
Epidermal growth factor receptor variant III-induced glioma invasion is mediated through myristoylated alanine-rich protein kinase C substrate overexpression.
Glioma
Epidermal growth factor-dependent cyclooxygenase-2 induction in gliomas requires protein kinase C-delta.
Glioma
Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells.
Glioma
Expression and regulation of phospholipase D isoforms in sphingosine and phorbol ester-stimulated glioma C6 cells.
Glioma
Glioma invasion in vitro: regulation by matrix metalloprotease-2 and protein kinase C.
Glioma
Glutathione depletion induces giant DNA and high-molecular-weight DNA fragmentation associated with apoptosis through lipid peroxidation and protein kinase C activation in C6 glioma cells.
Glioma
Heterogeneity of protein kinase C activity in human U-373 and G-26 mice glioma cells.
Glioma
High-affinity taurine uptake and its regulation by protein kinase C in human glioma cells.
Glioma
High-dose tamoxifen in treatment of brain tumors: interaction with antiepileptic drugs.
Glioma
Human glioma PKC-iota and PKC-betaII phosphorylate cyclin-dependent kinase activating kinase during the cell cycle.
Glioma
In situ effects of interferon on human glioma protein kinase C-alpha and -beta ultrastructural localization.
Glioma
In vitro identification of mitochondrial oxidative stress production by time-resolved fluorescence imaging of glioma cells.
Glioma
Induction of BAALC and down regulation of RAMP3 in astrocytes treated with differentiation inducers.
Glioma
Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C delta. Implications for Sindbis virus-induced apoptosis.
Glioma
Inhibition of ?-opioid receptors induces brain glioma cell apoptosis through the mitochondrial and protein kinase C pathways.
Glioma
Inhibition of growth of established human glioma cell lines by modulators of the protein kinase-C system.
Glioma
Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor.
Glioma
Inorganic lead stimulates DNA synthesis in human astrocytoma cells: role of protein kinase Calpha.
Glioma
Insulin-like growth factor I modulates voltage-dependent Ca2+ channels in neuronal cells.
Glioma
Intracellular signaling pathways involved in the cell growth inhibition of glioma cells by melatonin.
Glioma
Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression.
Glioma
Involvement of phospholipase D and protein kinase C in phorbol ester and fatty acid stimulated turnover of phosphatidylcholine and phosphatidylethanolamine in neural cells.
Glioma
Involvement of protein kinase C in melatonin's oncostatic effect in C6 glioma cells.
Glioma
In silico analysis identified miRNA?based therapeutic agents against glioblastoma multiforme.
Glioma
Malignant glioma sensitivity to radiotherapy, high-dose tamoxifen, and hypericin: corroborating clinical response in vitro: case report.
Glioma
Measuring the lactate-to-creatine ratio via 1H NMR spectroscopy can be used to noninvasively evaluate apoptosis in glioma cells after X-ray irradiation.
Glioma
Mitogenic signaling via endogenous kappa-opioid receptors in C6 glioma cells: evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascade.
Glioma
Model experiments on squid axons and NG108-15 mouse neuroblastoma x rat glioma hybrid cells.
Glioma
Modulation of mitochondrial metabolic function by phorbol 12-myristate 13-acetate through increased mitochondrial translocation of protein kinase Calpha in C2C12 myocytes.
Glioma
Myristoylated alanine-rich C-kinase substrate is phosphorylated and translocated by a phorbol ester-insensitive and calcium-independent protein kinase C isoform in C6 glioma cell membranes.
Glioma
Nicotine- and tar-free cigarette smoke extract induces cell injury via intracellular Ca2+-dependent subtype-specific protein kinase C activation.
Glioma
Opposite effects of the overexpression of protein kinase C gamma and delta on the growth properties of human glioma cell line U251 MG.
Glioma
Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-kappaB/Sp1-mediated signaling pathways.
Glioma
P2U-purinergic receptors on C6-2B rat glioma cells: modulation of cytosolic Ca2+ and cAMP levels by protein kinase C.
Glioma
Paradoxical elevation of Ki-67 labeling with protein kinase inhibition in malignant gliomas.
Glioma
Penta-acetyl geniposide-induced C6 glioma cell apoptosis was associated with the activation of protein kinase C-delta.
Glioma
Phosphatidylethanol biosynthesis in ethanol-exposed NG108-15 neuroblastoma X glioma hybrid cells. Evidence for activation of a phospholipase D phosphatidyl transferase activity by protein kinase C.
Glioma
Phospholipase D hydrolysis of plasmalogen and diacyl ethanolamine phosphoglycerides by protein kinase C dependent and independent mechanisms.
Glioma
Picroliv -- a natural product protects cells and regulates the gene expression during hypoxia/reoxygenation.
Glioma
PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival.
Glioma
Plasma pharmacokinetics and cerebrospinal fluid penetration of hypericin in nonhuman primates.
Glioma
Protein expression of the alpha, gamma, delta and epsilon subspecies of protein kinase C changes as C6 glioma cells become contact inhibited and quiescent in the presence of serum.
Glioma
Protein expression of the epsilon subspecies of protein kinase C ceases as Swiss 3T6 fibroblasts increase in cell density even though message for the protein is still present.
Glioma
Protein kinase A- and protein kinase C-regulated interaction of plectin with lamin B and vimentin.
Glioma
Protein kinase C activation decreases cell surface expression of the GLT-1 subtype of glutamate transporter. Requirement of a carboxyl-terminal domain and partial dependence on serine 486.
Glioma
Protein kinase C activation increases the rate and magnitude of agonist-induced delta-opioid receptor down-regulation in NG108-15 cells.
Glioma
Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase C.
Glioma
Protein kinase C alpha, delta, epsilon and zeta in C6 glioma cells. TPA induces translocation and down-regulation of conventional and new PKC isoforms but not atypical PKC zeta.
Glioma
Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashion.
Glioma
Protein kinase C inhibitors arrest the C6 glioma cell cycle at a mid-G1 phase restriction point: Implications for the antiproliferative action of valproate.
Glioma
Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines. A comparison between staurosporine and tamoxifen.
Glioma
Protein kinase C is involved in cholecystokinin octapeptide-induced proliferative action in rat glioma C6 cells.
Glioma
Protein kinase C isoform alpha overexpression in C6 glioma cells and its role in cell proliferation.
Glioma
Protein kinase C isoform delta is involved in the stimulation of the Na(+)-H+ exchanger in C6 glioma cells.
Glioma
Protein kinase C isoforms and growth, differentiation and phosphatidylcholine turnover in human neuroblastoma cells.
Glioma
Protein kinase C mediates induced secretion of vascular endothelial growth factor by human glioma cells.
Glioma
Protein kinase C-dependent cell damage by unsaturated carbonyl compounds in vascular cells.
Glioma
Protein kinase C-mediated down-regulation of beta(2)-adrenergic receptor and gene expression in rat C6 glioma cells.
Glioma
Protein kinase C-mediated down-regulation of beta1-adrenergic receptor gene expression in rat C6 glioma cells.
Glioma
Protein kinase C-mediated in vitro invasion of human glioma cells through extracellular-signal-regulated kinase and ornithine decarboxylase.
Glioma
Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B.
Glioma
Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells.
Glioma
Protein kinase Calpha isoform regulates the activation of the MAP kinase ERK1/2 in human glioma cells: involvement in cell survival and gene expression.
Glioma
Protein kinase translocation following beta-adrenergic receptor activation in C6 glioma cells.
Glioma
Reduction of protein kinase C delta attenuates tenascin-C stimulated glioma invasion in three-dimensional matrix.
Glioma
Regulation of the functional activity of the human dopamine transporter by protein kinase C.
Glioma
Regulation of the neuronal glutamate transporter excitatory amino acid carrier-1 (EAAC1) by different protein kinase C subtypes.
Glioma
Response of malignant glioma cell lines to activation and inhibition of protein kinase C-mediated pathways.
Glioma
Ribozyme inhibition of the protein kinase C alpha triggers apoptosis in glioma cells.
Glioma
Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD.
Glioma
RTVP-1 expression is regulated by SRF downstream of protein kinase C and contributes to the effect of SRF on glioma cell migration.
Glioma
Searching for combination therapy by clustering methods: Stimulation of PKC in Golgi apparatus combined with hypericin induced PDT.
Glioma
Selective activation of protein kinase C isoforms by angiotensin II in neuroblastoma X glioma cells.
Glioma
Semi-Synthetic Ingenol Derivative from Euphorbia tirucalli Inhibits Protein Kinase C Isotypes and Promotes Autophagy and S-phase Arrest on Glioma Cell Lines.
Glioma
Sensitivity of human glioma U-373MG cells to radiation and the protein kinase C inhibitor, calphostin C.
Glioma
Sensitization of C6 glioma cells to radiation by staurosporine, a potent protein kinase C inhibitor.
Glioma
Serine base exchange enzyme activity is modulated by sphingosine and other amphiphilic compounds: possible role of positive charge in increasing the synthesis of phosphatidylserine.
Glioma
Signal transduction for proliferation of glioma cells in vitro occurs predominantly through a protein kinase C-mediated pathway.
Glioma
Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways.
Glioma
Specific gene suppression using antisense strategy for growth suppression of glioma.
Glioma
Sphingosine and phorbol ester modulate protein kinase C activity and modify ATP-evoked calcium mobilization in glioma C6 cells.
Glioma
Staurosporine and its derivative RO31-8220, both inhibitors of protein kinase C, have different effects on C6 glioma cell morphology.
Glioma
Stimulation of A(2A) adenosine receptor phosphorylation by protein kinase C activation: evidence for regulation by multiple protein kinase C isoforms.
Glioma
Structural determinants for post-transcriptional stabilization of lactate dehydrogenase A mRNA by the protein kinase C signal pathway.
Glioma
Study of O-glycan sialylation in C6 cultured glioma cells: regulation of a beta-galactoside alpha 2,3 sialyltransferase activity by Ca2+/calmodulin antagonists and phosphatase inhibitors.
Glioma
Tamoxifen increases photodynamic therapeutic response of U87 and U25ln human glioma cells.
Glioma
The anchoring protein RACK1 links protein kinase Cepsilon to integrin beta chains. Requirements for adhesion and motility.
Glioma
The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro.
Glioma
The efficacy of tamoxifen as an antiproliferative agent in vitro for benign and malignant pediatric glial tumors.
Glioma
The flashlights on a distinct role of protein kinase C ?: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells.
Glioma
The heat shock protein antagonist 17-AAG potentiates the activity of enzastaurin against malignant human glioma cells.
Glioma
The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells.
Glioma
The role of protein kinase C (PKC) in the evolution and proliferation of malignant gliomas, and the application of PKC inhibition as a novel approach to anti-glioma therapy.
Glioma
The role of protein kinase C in migration of rat glioma cells from spheroid cultures.
Glioma
Transcriptional regulation of the lactate dehydrogenase A subunit gene by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.
Glioma
Transition metal chelator TPEN counteracts phorbol ester-induced actin cytoskeletal disruption in C6 rat glioma cells without inhibiting activation or translocation of protein kinase C.
Glioma
Ultrastructural study of protein kinase C-betaII localization during the cell cycle of human glioma cells.
Glioma
Ursolic acid inhibits IL-1beta or TNF-alpha-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-zeta and downregulating the MMP-9 expression.
Glioma
Verapamil augments carmustine- and irradiation-induced senescence in glioma cells by reducing intracellular reactive oxygen species and calcium ion levels.
Glioma
Water permeability through aquaporin-4 is regulated by protein kinase C and becomes rate-limiting for glioma invasion.
Glioma
Whole-cell recording of neuroblastoma x glioma cells during downregulation of a major substrate, 80K/MARCKS, of protein kinase C.
Gliosarcoma
Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples.
Glomerulonephritis
Expression of Ser729 phosphorylated PKCepsilon in experimental crescentic glomerulonephritis: an immunohistochemical study.
Glomerulonephritis
Protein kinase C beta II isoform is up-regulated in human proliferative glomerulonephritis.
Glomerulonephritis
Protein kinase C ß inhibition ameliorates experimental mesangial proliferative glomerulonephritis.
Glomerulonephritis, Membranoproliferative
Evaluation of renal gene expression of protein kinase C (PKC) isoforms in diabetic and nondiabetic proliferative glomerular diseases.
Glomerulonephritis, Membranous
Glomerular clusterin is associated with PKC-alpha/beta regulation and good outcome of membranous glomerulonephritis in humans.
Glucagonoma
An immunohistochemical study of glucagonoma conducted on the metastatic lymph nodes from a patient with recurrent metastatic glucagonoma: report of a case.
Glucagonoma
Expression, intracellular localization, and gene transcription regulation of the secretory protein 7B2 in endocrine pancreatic cell lines and human insulinomas.
Glucose Intolerance
Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise.
Glucose Intolerance
Deletion of Protein Kinase C ? in POMC Neurons Predisposes to Diet-Induced Obesity.
Glucose Intolerance
Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta.
Glucose Intolerance
Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus.
Glucose Intolerance
Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.
Glucose Intolerance
Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3' kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance.
Glucose Intolerance
PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance.
Glucose Intolerance
PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance.
Glucose Intolerance
Protein kinase c? modulates insulin receptor localization and trafficking in mouse embryonic fibroblasts.
Glucose Intolerance
Role of adipose and hepatic atypical protein kinase C lambda (PKC?) in the development of obesity and glucose intolerance.
Goiter
Immunohistochemical evidence for the overexpression of protein kinase C in proliferative diseases of human thyroid.
Gram-Negative Bacterial Infections
The scaffold MyD88 acts to couple protein kinase Cepsilon to Toll-like receptors.
Granuloma
An explant technique for high-resolution imaging and manipulation of mycobacterial granulomas.
Granuloma
Inhibition of a model of in vitro granuloma formation by tetracyclines and ciprofloxacin. Involvement of protein kinase C.
Granulomatous Disease, Chronic
Activation of the human immunodeficiency virus-1 long terminal repeat by respiratory burst oxidants of neutrophils.
Granulomatous Disease, Chronic
Protein kinases potentially capable of catalyzing the phosphorylation of p47-phox in normal neutrophils and neutrophils of patients with chronic granulomatous disease.
Granulomatous Disease, Chronic
Purified protein kinase C phosphorylates a 47-kDa protein in control neutrophil cytoplasts but not in neutrophil cytoplasts from patients with the autosomal form of chronic granulomatous disease.
Granulomatous Disease, Chronic
Reciprocal interactions between protein kinase C and components of the NADPH oxidase complex may regulate superoxide production by neutrophils stimulated with a phorbol ester.
Growth Hormone-Secreting Pituitary Adenoma
Phorbol ester, not growth hormone releasing factor, consistently stimulates growth hormone release from somatotroph adenomas in culture.
Head and Neck Neoplasms
Preclinical development of a bifunctional cancer cell homing, PKCepsilon inhibitory peptide for the treatment of head and neck cancer.
Hearing Loss, Noise-Induced
[Protective effect of indirect activator of calcium pump on noise-induced hearing loss]
Hearing Loss, Sensorineural
Contribution of 1425G/A Polymorphism in Protein Kinase C-Eta (PRKCH) Gene and Brain White Matter Lesions to the Risk of Sudden Sensorineural Hearing Loss in a Japanese Nested Case-Control Study.
Heart Arrest
Hydrogen Sulfide Decreases Blood-Brain Barrier Damage via Regulating Protein Kinase C and Tight Junction After Cardiac Arrest in Rats.
Heart Arrest
Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation.
Heart Arrest
Protein kinase C delta modulates endothelial nitric oxide synthase after cardiac arrest.
Heart Arrest
Protein kinase C epsilon activation delays neuronal depolarization during cardiac arrest in the euthermic arctic ground squirrel.
Heart Diseases
LENGTH-DEPENDENT ACTIVATION IS MODULATED BY CARDIAC TROPONIN I BISPHOSPHORYLATION AT SER23 AND SER24 BUT NOT BY THR143 PHOSPHORYLATION.
Heart Diseases
Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC.
Heart Diseases
Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.
Heart Diseases
The osteogenic or adipogenic lineage commitment of human mesenchymal stem cells is determined by protein kinase C delta.
Heart Failure
Adenovirus-delivered short hairpin RNA targeting PKCalpha improves contractile function in reconstituted heart tissue.
Heart Failure
Agonist activated PKC?II translocation and modulation of cardiac myocyte contractile function.
Heart Failure
alpha-Adrenergic response and myofilament activity in mouse hearts lacking PKC phosphorylation sites on cardiac TnI.
Heart Failure
Alterations in Ca2+ cycling proteins and G alpha q signaling after left ventricular assist device support in failing human hearts.
Heart Failure
Alterations in protein kinase A and protein kinase C levels in heart failure due to genetic cardiomyopathy.
Heart Failure
Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy.
Heart Failure
Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure.
Heart Failure
Beta- and alpha-adrenergic cross-signaling for L-type Ca current is impaired in transgenic mice with constitutive activation of epsilonPKC.
Heart Failure
Cardiac contractile dysfunction and protein kinase C-mediated myofilament phosphorylation in disease and aging.
Heart Failure
Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region.
Heart Failure
CPU228, a derivative of dofetilide, relieves cardiac dysfunction by normalizing FKBP12.6, NADPH oxidase and protein kinase C epsilon in the myocardium.
Heart Failure
Diacylglycerol kinase zeta attenuates pressure overload-induced cardiac hypertrophy.
Heart Failure
Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice.
Heart Failure
Differential Effects of Phosphorylation of Regions of Troponin I in Modifying Cooperative Activation of Cardiac Thin Filaments.
Heart Failure
Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in Dahl salt-sensitive rats.
Heart Failure
Differential regulation of diacylglycerol kinase isoform in human failing hearts.
Heart Failure
Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of G{alpha}q protein-induced cardiomyopathy.
Heart Failure
Effect of angiotensin-converting enzyme inhibition on protein kinase C and SR proteins in heart failure.
Heart Failure
Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes.
Heart Failure
Expression of protein kinase C isoforms in cardiac hypertrophy and heart failure due to volume overload.
Heart Failure
Fosinopril and carvedilol reverse hypertrophy and change the levels of protein kinase C epsilon and components of its signaling complex.
Heart Failure
Functional communication between PKC-targeted cardiac troponin I phosphorylation sites.
Heart Failure
Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium.
Heart Failure
Genetic association between 1425G/A SNP in PRKCH and hypertrophic cardiomyopathy in a Chinese population.
Heart Failure
Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure.
Heart Failure
In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts.
Heart Failure
Increased expression of protein kinase C isoforms in heart failure due to myocardial infarction.
Heart Failure
Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart.
Heart Failure
Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure.
Heart Failure
Mast cells and epsilonPKC: a role in cardiac remodeling in hypertension-induced heart failure.
Heart Failure
Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases.
Heart Failure
Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation.
Heart Failure
Peripheral vascular smooth muscle responsiveness to tumour-promoting phorbol esters in pacing-induced heart failure.
Heart Failure
Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model.
Heart Failure
Pharmacological inhibition of epsilon-protein kinase C attenuates cardiac fibrosis and dysfunction in hypertension-induced heart failure.
Heart Failure
Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure.
Heart Failure
Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes.
Heart Failure
Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function.
Heart Failure
Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes.
Heart Failure
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
Heart Failure
PKC?II inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses: PKC?II in cardiac remodeling.
Heart Failure
Protein kinase C epsilon induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism.
Heart Failure
Protein kinase C in the human heart: differential regulation of the isoforms in aortic stenosis or dilated cardiomyopathy.
Heart Failure
Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure.
Heart Failure
Protein kinase C promotes cardiac fibrosis and heart failure by modulating galectin-3 expression.
Heart Failure
Protein kinase C, troponin I and heart failure: overexpressed, hyperphosphorylated and underappreciated?
Heart Failure
Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.
Heart Failure
Regulation of the endothelin-1 transmembrane signaling pathway: the potential role of agonist-induced desensitization in the coronary artery of the rapid ventricular pacing-overdrive dog model of heart failure.
Heart Failure
Regulatory Variants Modulate Protein Kinase C ? (PRKCA) Gene Expression in Human Heart.
Heart Failure
Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation.
Heart Failure
Searching for the missing link: a role for the actin capping protein in heart failure.
Heart Failure
Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta.
Heart Failure
Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca
Heart Failure
[Protein interacting with kinase C? mediates the down-regulation of myocardial norepinephrine transporter expression in mice with adriamycin-induced congestive heart failure].
Heart Septal Defects, Ventricular
Protein kinase C in the human heart: differential regulation of the isoforms in aortic stenosis or dilated cardiomyopathy.
Hemangioma
The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells.
Hematologic Neoplasms
Platelet expression of PKCepsilon oncoprotein in myelofibrosis is associated with disease severity and thrombotic risk.
Hematologic Neoplasms
The therapeutic role of targeting protein kinase C in solid and hematologic malignancies.
Hematoma, Subdural, Acute
Early changes in second messenger but not receptor binding sites after acute subdural hematoma: an in vitro autoradiographic study.
Hepatitis
Assembly of hepatitis delta virus particles: package of multimeric hepatitis delta virus genomic RNA and role of phosphorylation.
Hepatitis
Casein kinase II and protein kinase C modulate hepatitis delta virus RNA replication but not empty viral particle assembly.
Hepatitis
Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis.
Hepatitis
Protein kinase C alpha location and the expression of phospho-MEK and MDR1 in hepatitis virus-related hepatocellular carcinoma biopsies.
Hepatitis B
Effect of core protein phosphorylation by protein kinase C on encapsidation of RNA within core particles of hepatitis B virus.
Hepatitis B
Hepatitis B virus core interacts with the host cell nucleolar protein, nucleophosmin 1.
Hepatitis B
Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C.
Hepatitis B
Identification of a protein kinase C (PKC) activator, daphnoretin, that suppresses hepatitis B virus gene expression in human hepatoma cells.
Hepatitis B
Inhibition of protein kinase C phosphorylation of hepatitis B virus capsids inhibits virion formation and causes intracellular capsid accumulation.
Hepatitis B
Interferon-? suppresses hepatitis B virus enhancer II activity via the protein kinase C pathway.
Hepatitis B
Phosphorylation of purified recombinant hepatitis B virus-X protein by mitogen-activated protein kinase and protein kinase C in vitro.
Hepatitis B
PTEN modulates insulin-like growth factor II (IGF-II)-mediated signaling; the protein phosphatase activity of PTEN downregulates IGF-II expression in hepatoma cells.
Hepatitis B
The hepatitis B virus transactivator HBx causes elevation of diacylglycerol and activation of protein kinase C.
Hepatitis B
The novel immunosuppressive protein kinase C inhibitor sotrastaurin has no pro-viral effects on the replication cycle of hepatitis B or C virus.
Hepatitis B
Transactivation of human hepatitis B virus X protein, HBx, operates through a mechanism distinct from protein kinase C and okadaic acid activation pathways.
Hepatitis C
A synthetic peptide derived from the non-structural protein 3 of hepatitis C virus serves as a specific substrate for PKC.
Hepatitis C
Conventional protein kinase C inhibition prevents alpha interferon-mediated hepatitis C virus replicon clearance by impairing STAT activation.
Hepatitis C
Phosphorylation of hepatitis C virus core protein by protein kinase A and protein kinase C.
Hepatitis C
Protein kinase C recognizes the protein kinase A-binding motif of nonstructural protein 3 of hepatitis C virus.
Hepatitis C
Regulation of the biochemical function of motif VI of HCV NTPase/helicase by the conserved Phe-loop.
Hepatitis C
The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration.
Hepatitis C
The NTPase/helicase domain of hepatitis C virus nonstructural protein 3 inhibits protein kinase C independently of its NTPase activity.
Hepatitis E
Biological or pharmacological activation of protein kinase C alpha constrains hepatitis E virus replication.
Hepatoblastoma
Hypoglycemia-induced VEGF expression is mediated by intracellular Ca2+ and protein kinase C signaling pathway in HepG2 human hepatoblastoma cells.
Hepatoblastoma
Protein kinase C-dependent distribution of the multidrug resistance protein 2 from the canalicular to the basolateral membrane in human HepG2 cells.
Herpes Simplex
Effect of protein kinase C inhibitors on the antiviral activity of human alpha interferon in herpes simplex virus-infected human neuroblastoma cells.
Herpes Simplex
Enhanced auditory reversal learning by genetic activation of protein kinase C in small groups of rat hippocampal neurons.
Herpes Simplex
Gene transfer of constitutively active protein kinase C into striatal neurons accelerates onset of levodopa-induced motor response alterations in parkinsonian rats.
Herpes Simplex
Growth inhibition of herpes simplex virus-type 1 in calphostin C-treated astrocytes.
Herpes Simplex
Herpes simplex virus type 1 infection induces activation and recruitment of protein kinase C to the nuclear membrane and increased phosphorylation of lamin B.
Herpes Simplex
Modulation of rat rotational behavior by direct gene transfer of constitutively active protein kinase C into nigrostriatal neurons.
Herpes Simplex
Phospholipid-sensitive, Ca2+-dependent protein kinase activity in rat embryo fibroblasts transformed by herpes simplex virus type 2.
Herpes Simplex
Protein kinase C epsilon contributes to basal and sensitizing responses of TRPV1 to capsaicin in rat dorsal root ganglion neurons.
Herpes Simplex
Role of tyrosine kinases, protein kinase C, and protein kinase A in the regulation of interferon-alpha production induced by herpes simplex virus type 1.
Herpes Zoster
A role for protein tyrosine kinase in the steroidogenic pathway of angiotensin II in bovine zona glomerulosa cells.
Herpes Zoster
Control of CYP11B2 gene expression through differential regulation of its promoter by atypical and conventional protein kinase C isoforms.
Herpes Zoster
Correction: Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C ?-mediated zona occludens-1 phosphorylation at threonine 770/772.
Herpes Zoster
Effect of protein kinase C stimulators on zona pellucida binding and the acrosome reaction of macaque sperm.
Herpes Zoster
Effects of sevoflurane on tight junction protein expression and PKC-? translocation after pulmonary ischemia-reperfusion injury.
Herpes Zoster
Epithelial-mesenchymal status influences how cells deposit fibrillin microfibrils.
Herpes Zoster
Internalization of the type I angiotensin II receptor (AT1) is required for protein kinase C activation but not for inositol trisphosphate release in the angiotensin II stimulated rat adrenal zona glomerulosa cell.
Herpes Zoster
Phosphorylation of atrial natriuretic factor R1 receptor by serine/threonine protein kinases: evidences for receptor regulation.
Herpes Zoster
PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7.
Herpes Zoster
Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4.
Herpes Zoster
Protein kinase C activation stimulates calcium transport in adrenal zona glomerulosa cells.
Herpes Zoster
Protein kinase C plays an important role in the human zona pellucida-induced acrosome reaction.
Herpes Zoster
Regulation of the polyspermy block in the mouse egg: maturation-dependent differences in cortical granule exocytosis and zona pellucida modifications induced by inositol 1,4,5-trisphosphate and an activator of protein kinase C.
Herpes Zoster
The AP-1 family member FOS blocks transcriptional activity of the nuclear receptor steroidogenic factor 1.
Herpes Zoster
The protein kinase C content is increased in the nuclear fraction of rat adrenal zona glomerulosa following long-term ACTH administration.
Herpes Zoster
Trypsin stimulation of aldosterone and 18-hydroxycorticosterone production by rat adrenal zona glomerulosa tissue is mediated by activation of protein kinase C.
Herpes Zoster
Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C ?-mediated zona occludens-1 phosphorylation at threonine 770/772.
Hirschsprung Disease
Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity.
Histiocytoma, Benign Fibrous
Fusions involving protein kinase C and membrane-associated proteins in benign fibrous histiocytoma.
Histiocytosis
Interferon-alpha therapy, protein kinase C-alpha and Langerhans cell histiocytosis.
Histiocytosis, Langerhans-Cell
Interferon-alpha therapy, protein kinase C-alpha and Langerhans cell histiocytosis.
HIV Infections
Bestatin-mediated inhibition of leucine aminopeptidase may hinder HIV infection.
HIV Infections
Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages.
HIV Infections
Enhancement of radiosensitivity in human malignant glioma cells by hypericin in vitro.
HIV Infections
Human immunodeficiency virus infection of monocytes: relationship to Fc-gamma receptors and antibody-dependent viral enhancement.
HIV Infections
Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes.
HIV Infections
Targeting NF-?B signaling with protein kinase C agonists as an emerging strategy for combating HIV latency.
Hodgkin Disease
Defective Bax activation in Hodgkin B-cell lines confers resistance to staurosporine-induced apoptosis.
Hodgkin Disease
PKCeta Expression Contributes to the Resistance of Hodgkin's Lymphoma Cell Lines to Apoptosis.
Huntington Disease
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Huntington Disease
Impaired degradation of PKCalpha by proteasome in a cellular model of Huntington's disease.
Huntington Disease
Pro-apoptotic protein kinase C delta is associated with intranuclear inclusions in a transgenic model of Huntington's disease.
Huntington Disease
Protein kinase C beta II mRNA levels decrease in the striatum and cortex of transgenic Huntington's disease mice.
Huntington Disease
Second messenger systems in brains of patients with Parkinson's or Huntington's disease.
Huntington Disease
The loss of beta II-protein kinase C in the striatum from patients with Huntington's disease.
Hyperaldosteronism
Increased Na(+)-H+ exchange in red blood cells of patients with primary aldosteronism.
Hyperalgesia
5-HT2A Receptor-Induced Morphological Reorganization of PKC?-Expressing Interneurons Gates Inflammatory Mechanical Allodynia in Rat.
Hyperalgesia
A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice.
Hyperalgesia
A single-center, randomized, double-blind, active, and placebo-controlled study of KAI-1678, a novel PKC-epsilon inhibitor, in the treatment of acute postoperative orthopedic pain.
Hyperalgesia
A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators.
Hyperalgesia
Activation of ?1 adrenoceptors in ventrolateral orbital cortex attenuates allodynia induced by spared nerve injury in rats.
Hyperalgesia
Activation of G(i) induces mechanical hyperalgesia poststress or inflammation.
Hyperalgesia
Activation of medullary dorsal horn ? isoform of protein kinase C interneurons is essential to the development of both static and dynamic facial mechanical allodynia.
Hyperalgesia
Activation of protein kinase C in the spinal cord produces mechanical hyperalgesia by activating glutamate receptors, but does not mediate chronic muscle-induced hyperalgesia.
Hyperalgesia
Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I.
Hyperalgesia
Acute thermal hyperalgesia in the rat is produced by activation of N-methyl-D-aspartate receptors and protein kinase C and production of nitric oxide.
Hyperalgesia
AMPK activation by peri-sciatic nerve administration of ozone attenuates CCI-induced neuropathic pain in rats.
Hyperalgesia
Antinociceptive and antiedematogenic activities of fenofibrate, an agonist of PPAR alpha, and pioglitazone, an agonist of PPAR gamma.
Hyperalgesia
Astrocyte D-serine modulates the activation of neuronal NOS leading to the development of mechanical allodynia in peripheral neuropathy.
Hyperalgesia
Bradykinin lowers the threshold temperature for heat activation of vanilloid receptor 1.
Hyperalgesia
Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat.
Hyperalgesia
Contribution of Ca(2+) -dependent protein kinase C in the spinal cord to the development of mechanical allodynia in diabetic mice.
Hyperalgesia
Contribution of Spinal PKC? Expression to Short- and Long-lasting Pain Behaviors in Formalin-induced Inflamed Mice.
Hyperalgesia
Contribution of transient receptor potential vanilloid subfamily 1 to endothelin-1-induced thermal hyperalgesia.
Hyperalgesia
Cross-Talk of Toll-Like Receptor 5 and Mu-Opioid Receptor Attenuates Chronic Constriction Injury-Induced Mechanical Hyperalgesia through a Protein Kinase C Alpha-Dependent Signaling.
Hyperalgesia
D-2-amino-5-phosphonopentanoic acid inhibits intrathecal pertussis toxin-induced thermal hyperalgesia and protein kinase Cgamma up-regulation.
Hyperalgesia
Different peripheral mechanisms mediate enhanced nociception in metabolic/toxic and traumatic painful peripheral neuropathies in the rat.
Hyperalgesia
Differential regulation of peripheral IL-1?-induced mechanical allodynia and thermal hyperalgesia in rats.
Hyperalgesia
Direct evidence for the involvement of brain-derived neurotrophic factor in the development of a neuropathic pain-like state in mice.
Hyperalgesia
Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism.
Hyperalgesia
Ethanol withdrawal-associated allodynia and hyperalgesia: age-dependent regulation by protein kinase C epsilon and gamma isoenzymes.
Hyperalgesia
Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma.
Hyperalgesia
Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain.
Hyperalgesia
Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation.
Hyperalgesia
Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia.
Hyperalgesia
Glycine Inhibitory Dysfunction Turns Touch into Pain through PKCgamma Interneurons.
Hyperalgesia
H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathway.
Hyperalgesia
Hyperalgesia induced by peripheral inflammation is mediated by protein kinase C betaII isozyme in the rat spinal cord.
Hyperalgesia
Identification of a Protein Kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel.
Hyperalgesia
Implication of endogenous beta-endorphin in the inhibition of the morphine-induced rewarding effect by the direct activation of spinal protein kinase C in mice.
Hyperalgesia
Implication of spinal protein kinase Cgamma isoform in activation of the mouse brain by intrathecal injection of the protein kinase C activator phorbol 12,13-dibutyrate using functional magnetic resonance imaging analysis.
Hyperalgesia
Implications of intrathecal pertussis toxin animal model on the cellular mechanisms of neuropathic pain syndrome.
Hyperalgesia
Increases in protein kinase C gamma immunoreactivity in the spinal cord dorsal horn of rats with painful mononeuropathy.
Hyperalgesia
Induction of c-fos expression in the mouse brain associated with hyperalgesia induced by intrathecal injection of protein kinase C activator.
Hyperalgesia
Inflammatory muscle pain is dependent on the activation of kinin B(1) and B(2) receptors and intracellular kinase pathways.
Hyperalgesia
Inhibition of Nerve Growth Factor Signaling Alleviates Repeated Dural Stimulation-induced Hyperalgesia in Rats.
Hyperalgesia
Inhibition of spinal protein kinase C blocks substance P-mediated hyperalgesia.
Hyperalgesia
Inhibition of spinal protein kinase C reduces nerve injury-induced tactile allodynia in neuropathic rats.
Hyperalgesia
Inhibition of the morphine-induced rewarding effect by direct activation of spinal protein kinase C in mice.
Hyperalgesia
Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling.
Hyperalgesia
Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers.
Hyperalgesia
Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model.
Hyperalgesia
Involvement of protein kinase C in 5-HT-evoked thermal hyperalgesia and spinal fos protein expression in the rat.
Hyperalgesia
Involvement of spinal protein kinase C in induction and maintenance of both persistent spontaneous flinching reflex and contralateral heat hyperalgesia induced by subcutaneous bee venom in the conscious rat.
Hyperalgesia
Involvement of spinal protein kinase C in thermal hyperalgesia evoked by partial sciatic nerve ligation, but not by inflammation in the mouse.
Hyperalgesia
Involvement of the spinal NMDA receptor/PKCgamma signaling pathway in the development of bone cancer pain.
Hyperalgesia
Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat.
Hyperalgesia
L1 cell adhesion molecule is essential for the maintenance of hyperalgesia after spinal cord injury.
Hyperalgesia
Loose ligation of the rat sciatic nerve is accompanied by changes in the subcellular content of protein kinase C beta II and gamma in the spinal dorsal horn.
Hyperalgesia
Low-dose morphine induces hyperalgesia through activation of G alphas, protein kinase C, and L-type Ca 2+ channels in rats.
Hyperalgesia
Mechanical Allodynia Circuitry in the Dorsal Horn Is Defined by the Nature of the Injury.
Hyperalgesia
Mechanical hyperalgesia induced by endothelin-1 in rats is mediated via phospholipase C, protein kinase C, and MAP kinases.
Hyperalgesia
Melatonin prevents morphine-induced hyperalgesia and tolerance in rats: role of protein kinase C and N-methyl-D-aspartate receptors.
Hyperalgesia
Modulation of formalin-evoked hyperalgesia by intrathecal N-type Ca channel and protein kinase C inhibitor in the rat.
Hyperalgesia
Molecular interaction in the mouse PAG between NMDA and opioid receptors in morphine-induced acute thermal nociception.
Hyperalgesia
Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain.
Hyperalgesia
Neurochemical characterization of neuronal populations expressing protein kinase C gamma isoform in the spinal cord and gracile nucleus of the rat.
Hyperalgesia
Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia.
Hyperalgesia
Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C.
Hyperalgesia
Pain Facilitation and Activity-Dependent Plasticity in Pain Modulatory Circuitry: Role of BDNF-TrkB Signaling and NMDA Receptors.
Hyperalgesia
Peripheral group I metabotropic glutamate receptor activation leads to muscle mechanical hyperalgesia through TRPV1 phosphorylation in the rat.
Hyperalgesia
Peripheral Synthesis of an Atypical Protein Kinase C Mediates the Enhancement of Excitability and the Development of Mechanical Hyperalgesia Produced by Nerve Growth Factor.
Hyperalgesia
PICK1 Regulates the Expression and Trafficking of AMPA Receptors in Remifentanil-Induced Hyperalgesia.
Hyperalgesia
PKC?-positive neurons gate light tactile inputs to pain pathway through pERK1/2 neuronal network in trigeminal neuropathic pain model.
Hyperalgesia
PKCgamma contributes to a subset of the NMDA-dependent spinal circuits that underlie injury-induced persistent pain.
Hyperalgesia
PKCgamma receptor mediates visceral nociception and hyperalgesia following exposure to PTSD-like stress in the spinal cord of rats.
Hyperalgesia
PLC-beta 3 signals upstream of PKC epsilon in acute and chronic inflammatory hyperalgesia.
Hyperalgesia
Possible involvement of spinal protein kinase C in thermal allodynia and hyperalgesia in diabetic mice.
Hyperalgesia
Postnatal development of inner lamina II interneurons of the rat medullary dorsal horn.
Hyperalgesia
Primary afferent nociceptor mechanisms mediating NGF-induced mechanical hyperalgesia.
Hyperalgesia
Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia.
Hyperalgesia
Progesterone Prevents Nerve Injury-Induced Allodynia and Spinal NMDA Receptor Upregulation in Rats.
Hyperalgesia
Prokineticin 2 suppresses GABA-activated current in rat primary sensory neurons.
Hyperalgesia
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.
Hyperalgesia
Protein Kinase C ? Interneurons Mediate C-fiber-induced Orofacial Secondary Static Mechanical Allodynia, but Not C-fiber-induced Nociceptive Behavior.
Hyperalgesia
Protein kinase C gamma interneurons in the rat medullary dorsal horn: Distribution and synaptic inputs of these neurons, and subcellular localization of the enzyme.
Hyperalgesia
Protein kinase C inhibitor chelerythrine attenuates the morphine-induced excitatory amino acid release and reduction of the antinociceptive effect of morphine in rats injected intrathecally with pertussis toxin.
Hyperalgesia
Protein kinase C inhibitors decrease hyperalgesia and C-fiber hyperexcitability in the streptozotocin-diabetic rat.
Hyperalgesia
Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons.
Hyperalgesia
Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2.
Hyperalgesia
Real-Time Translocation and Function of PKC?II Isoform in Response to Nociceptive Signaling via the TRPV1 Pain Receptor.
Hyperalgesia
Reduced hyperalgesia induced by nerve injury, but not by inflammation in mice lacking protein kinase C gamma isoform.
Hyperalgesia
Relative roles of protein kinase A and protein kinase C in modulation of transient receptor potential vanilloid type 1 receptor responsiveness in rat sensory neurons in vitro and peripheral nociceptors in vivo.
Hyperalgesia
Role of endogenous melatoninergic system in development of hyperalgesia and tolerance induced by chronic morphine administration in rats.
Hyperalgesia
Role of melatonin in the prevention of morphine-induced hyperalgesia and spinal glial activation in rats: protein kinase C pathway involved.
Hyperalgesia
Role of Nociceptor Toll-like Receptor 4 (TLR4) in Opioid-Induced Hyperalgesia and Hyperalgesic Priming.
Hyperalgesia
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Hyperalgesia
Role of the sensory neuron cytoskeleton in second messenger signaling for inflammatory pain.
Hyperalgesia
Second messengers mediating the expression of neuroplasticity in a model of chronic pain in the rat.
Hyperalgesia
Sensitization of transient receptor potential vanilloid 1 by the prokineticin receptor agonist Bv8.
Hyperalgesia
Severity of alcohol-induced painful peripheral neuropathy in female rats: role of estrogen and protein kinase (A and Cepsilon).
Hyperalgesia
Sex hormones regulate the contribution of PKCepsilon and PKA signalling in inflammatory pain in the rat.
Hyperalgesia
Sexual dimorphism for protein kinase c epsilon signaling in a rat model of vincristine-induced painful peripheral neuropathy.
Hyperalgesia
Sexual dimorphism in the contribution of protein kinase C isoforms to nociception in the streptozotocin diabetic rat.
Hyperalgesia
Spinal protein kinase C/extracellular signal-regulated kinase signal pathway mediates hyperalgesia priming.
Hyperalgesia
State-dependent phosphorylation of epsilon-isozyme of protein kinase C in adult rat dorsal root ganglia after inflammation and nerve injury.
Hyperalgesia
Sympathetic-independent bradykinin mechanical hyperalgesia induced by subdiaphragmatic vagotomy in the rat.
Hyperalgesia
Synaptic Dynamics of the Feed-forward Inhibitory Circuitry Gating Mechanical Allodynia in Mice.
Hyperalgesia
Tamoxifen suppresses paclitaxel-, vincristine-, and bortezomib-induced neuropathy via inhibition of the protein kinase C/extracellular signal-regulated kinase pathway.
Hyperalgesia
The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin.
Hyperalgesia
The effects of phorbol ester on slowly conducting afferents of the cat's knee joint.
Hyperalgesia
The increased release of amino acid neurotransmitters of the primary somatosensory cortical area in rats contributes to remifentanil-induced hyperalgesia and its inhibition by lidocaine.
Hyperalgesia
The spinal antinociceptive mechanism determined by systemic administration of BD1047 in zymosan-induced hyperalgesia in rats.
Hyperalgesia
Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C.
Hyperalgesia
Transient attenuation of protein kinase Cepsilon can terminate a chronic hyperalgesic state in the rat.
Hyperalgesia
Transient decrease in nociceptor GRK2 expression produces long-term enhancement in inflammatory pain.
Hyperalgesia
TrkA and PKC-epsilon in thermal burn-induced mechanical hyperalgesia in the rat.
Hyperalgesia
Tumor necrosis factor receptor type-1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat.
Hyperalgesia
Tumour necrosis factor alpha mediates transient receptor potential vanilloid 1-dependent bilateral thermal hyperalgesia with distinct peripheral roles of interleukin-1beta, protein kinase C and cyclooxygenase-2 signalling.
Hyperalgesia
[Protein kinase C agonist phorbol 12-Myrstate-Acetate induces nociception and enhances nitric oxide production in the spinal cord of rats].
Hypercholesterolemia
Arginine uptake is attenuated, through post-translational regulation of cationic amino acid transporter-1, in hyperlipidemic rats.
Hypercholesterolemia
Exercise and hypercholesterolemia produce disparate shifts in coronary PKC expression.
Hypercholesterolemia
Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling.
Hypereosinophilic Syndrome
Regulation of Fc gamma receptor subtype expression on a human eosinophilic leukemia cell line EoL-3: participation of cAMP and protein kinase C in the effects of interferon-gamma and phorbol ester.
Hypereosinophilic Syndrome
The roles of MCP-1 and protein kinase Cdelta activation in human eosinophilic leukemia EoL-1 cells.
Hyperglycemia
Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy.
Hyperglycemia
Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.
Hyperglycemia
Activation of protein kinase c-delta and c-epsilon by oxidative stress in early diabetic rat kidney.
Hyperglycemia
Acute effects of glucose on reactivity of cerebral microcirculation: role of activation of protein kinase C.
Hyperglycemia
Acute hyperglycemia regulates transcription and posttranscriptional stability of PKCbetaII mRNA in vascular smooth muscle cells.
Hyperglycemia
Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat.
Hyperglycemia
Amelioration of diabetic nephropathy by oral administration of d-?-tocopherol and its mechanisms.
Hyperglycemia
An acute hyperglycemia or acidosis-induced changes of indolamines level correlates with PKC-alpha expression in rat brain.
Hyperglycemia
Arteriolar nitric oxide concentration is decreased during hyperglycemia-induced betaII PKC activation.
Hyperglycemia
Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications.
Hyperglycemia
Attenuation of mouse mesangial cell contractility by high glucose and mannitol: involvement of protein kinase C and focal adhesion kinase.
Hyperglycemia
Can protein kinase C inhibition and vitamin E prevent the development of diabetic vascular complications?
Hyperglycemia
Cellular and molecular mechanisms of vascular injury in diabetes - Part I: Pathways of vascular disease in diabetes.
Hyperglycemia
Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat.
Hyperglycemia
Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.
Hyperglycemia
Chronic effects of glucose on insulin signaling in A-10 vascular smooth muscle cells.
Hyperglycemia
Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity.
Hyperglycemia
Clinical biomarkers and molecular basis for optimized treatment of diabetic retinopathy: current status and future prospects.
Hyperglycemia
Complex modulation of the expression of PKC isoforms in the rat brain during chronic type 1 diabetes mellitus.
Hyperglycemia
Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism.
Hyperglycemia
Decreased Protein Kinase C Expression in the Cochlear Fibroblasts of Diabetic Rat Models Induced by Curcumin.
Hyperglycemia
Demonstration of the essential role of protein kinase C isoforms in hyperglycemia-induced embryonic malformations.
Hyperglycemia
Diabetes and Complications: Cellular Signalling Pathways, Current Understanding and Targeted Therapies.
Hyperglycemia
Diabetic Polyneuropathy in Type 2 Diabetes Mellitus: Inflammation, Oxidative Stress, and Mitochondrial Function.
Hyperglycemia
Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats.
Hyperglycemia
Effect of eicosapentaenoic acid on glucose-induced diacylglycerol synthesis in cultured bovine aortic endothelial cells.
Hyperglycemia
Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats.
Hyperglycemia
Effect of short-term hyperglycemia on protein kinase C alpha activation in human erythrocytes.
Hyperglycemia
Effects of hyperglycemia and hypercapnia on lipid metabolism during complete brain ischemia.
Hyperglycemia
Effects of hyperglycemia and protein kinase C on connexin43 expression in cultured rat retinal pigment epithelial cells.
Hyperglycemia
Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling.
Hyperglycemia
G protein-linked cell signaling and cardiovascular functions in diabetes/hyperglycemia.
Hyperglycemia
Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice.
Hyperglycemia
Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways.
Hyperglycemia
Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase.
Hyperglycemia
Glyco-oxidation and cardiovascular complications in type 2 diabetes: a clinical update.
Hyperglycemia
Hepatic steatosis by dietary-conjugated linoleic acid is accompanied by accumulation of diacylglycerol and increased membrane-associated protein kinase C ? in mice.
Hyperglycemia
Hyperglycemia and hypercapnia differently affect post-ischemic changes in protein kinases and protein phosphorylation in the rat cingulate cortex.
Hyperglycemia
Hyperglycemia enhances IGF-I-stimulated Src activation via increasing Nox4-derived reactive oxygen species in a PKC?-dependent manner in vascular smooth muscle cells.
Hyperglycemia
Hyperglycemia in vitro attenuates insulin-stimulated chemokinesis in normal human neutrophils. Role of protein kinase C activation.
Hyperglycemia
Hyperglycemia-induced changes in Na+/myo-inositol transport, Na(+)-K(+)-ATPase, and protein kinase C activity in proximal tubule cells.
Hyperglycemia
Hyperglycemia-induced Oxidative stress and its Role in Diabetes Mellitus related Cardiovascular Diseases.
Hyperglycemia
Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2.
Hyperglycemia
Immune response to fungi in diabetic patients with invasive fungal rhinosinusitis.
Hyperglycemia
Impairment of neurovascular coupling in type 1 diabetes mellitus in rats is linked to PKC modulation of BKCa and Kir channels.
Hyperglycemia
Increase in P-glycoprotein accompanied by activation of protein kinase Calpha and NF-kappaB p65 in the livers of rats with streptozotocin-induced diabetes.
Hyperglycemia
Increased expression of liver PKC alpha in hypoinsulinemic diabetic rats: a post-translational effect.
Hyperglycemia
Inhibitory effect of high concentration of glucose on relaxations to activation of ATP-sensitive K+ channels in human omental artery.
Hyperglycemia
Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy.
Hyperglycemia
Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo.
Hyperglycemia
Mechanisms underlying depressed Na+/Ca2+ exchanger activity in the diabetic heart.
Hyperglycemia
Metformin prevents glucose-induced protein kinase C-beta2 activation in human umbilical vein endothelial cells through an antioxidant mechanism.
Hyperglycemia
Metformin treatment ameliorates diabetes-associated decline in hippocampal neurogenesis and memory via phosphorylation of insulin receptor substrate 1.
Hyperglycemia
Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes.
Hyperglycemia
Molecular complexities underlying the vascular complications of diabetes mellitus - A comprehensive review.
Hyperglycemia
N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress.
Hyperglycemia
NADPH oxidase NOX1 is involved in activation of protein kinase C and premature senescence in early-stage diabetic kidney.
Hyperglycemia
New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis.
Hyperglycemia
Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling.
Hyperglycemia
Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels.
Hyperglycemia
Oral targeting of protein kinase C receptor: promising route for diabetic retinopathy?
Hyperglycemia
Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications.
Hyperglycemia
Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes.
Hyperglycemia
Oxidative Stress Biomarkers in the Relationship between Type 2 Diabetes and Air Pollution.
Hyperglycemia
Oxidative stress-associated vascular aging is independent of the protein kinase C/NAD(P)H oxidase pathway.
Hyperglycemia
Pathophysiology and treatment of diabetic peripheral neuropathy: the case for diabetic neurovascular function as an essential component.
Hyperglycemia
PKC? impaired vessel formation and angiogenic factor expression in diabetic ischemic limbs.
Hyperglycemia
PKCepsilon inhibits the hyperglycemia-induced apoptosis signal in adult rat ventricular myocytes.
Hyperglycemia
PKC{alpha} Mediates {beta}-Arrestin2-dependent Nephrin Endocytosis in Hyperglycemia.
Hyperglycemia
Platelet protein kinase C isoform content in type 2 diabetes complicated with retinopathy and nephropathy.
Hyperglycemia
Polyneuropathy in Impaired Glucose Tolerance: Is Postprandial Hyperglycemia the Main Culprit? A Mini-Review.
Hyperglycemia
Possible involvement of phospholipase D and protein kinase C in vascular growth induced by elevated glucose concentration.
Hyperglycemia
Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine.
Hyperglycemia
Protein kinase C activation affects, via the mRNA-binding Hu-antigen R/ELAV protein, vascular endothelial growth factor expression in a pericytic/endothelial coculture model.
Hyperglycemia
Protein kinase C activity is acutely regulated by plasma glucose concentration in human monocytes in vivo.
Hyperglycemia
Protein kinase C delta (PKC?) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1.
Hyperglycemia
Protein kinase C inhibits insulin-induced Akt activation in vascular smooth muscle cells.
Hyperglycemia
Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.
Hyperglycemia
Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia.
Hyperglycemia
Protein kinase C upregulates intercellular adhesion molecule-1 and leukocyte-endothelium interactions in hyperglycemia via activation of endothelial expressed calpain.
Hyperglycemia
Protein kinase C-delta modulates apoptosis induced by hyperglycemia in adult ventricular myocytes.
Hyperglycemia
Reactive oxygen species, reactive nitrogen species and antioxidants in etiopathogenesis of diabetes mellitus type-2.
Hyperglycemia
Regulation of protein kinases and coregulatory interplay of S-100beta and serotonin transporter on serotonin levels in diabetic rat brain.
Hyperglycemia
Retinal metabolic abnormalities in diabetic mouse: comparison with diabetic rat.
Hyperglycemia
Review of Diabetic Polyneuropathy: Pathogenesis, Diagnosis and Management According to the Consensus of Egyptian Experts.
Hyperglycemia
Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells.
Hyperglycemia
Role of basic fibroblast growth factor (FGF-2) in diabetic nephropathy and mechanisms of its induction by hyperglycemia in human renal fibroblasts.
Hyperglycemia
Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies.
Hyperglycemia
Role of oxidative stress, inflammation, hypoxia and angiogenesis in the development of diabetic retinopathy.
Hyperglycemia
Role of protein kinase C in the expression of endothelin converting enzyme-1.
Hyperglycemia
Role of Tight Glycemic Control during Acute Coronary Syndrome on CV Outcome in Type 2 Diabetes.
Hyperglycemia
Role of vasoactive factors in the pathogenesis of early changes in diabetic retinopathy.
Hyperglycemia
Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.
Hyperglycemia
Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy.
Hyperglycemia
The Oxidative Stress and Mitochondrial Dysfunction during the Pathogenesis of Diabetic Retinopathy.
Hyperglycemia
The role of protein kinase C in the development of the complications of diabetes.
Hyperglycemia
Vascular endothelial dysfunction in diabetic cardiomyopathy: pathogenesis and potential treatment targets.
Hyperglycemia
[Heart pathology of extracardiac origin. XI. Cardiac repercussions of diabetes mellitus]
Hyperinsulinism
Antagonism of endotoxic glucose dyshomeostasis by protein kinase C inhibitors.
Hyperinsulinism
Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta.
Hyperinsulinism
Insulin-induced Akt activation is inhibited by angiotensin II in the vasculature through protein kinase C-alpha.
Hyperinsulinism
Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1.
Hyperinsulinism
Lysophosphatidylcholine inhibits insulin-induced Akt activation through protein kinase C-alpha in vascular smooth muscle cells.
Hyperinsulinism
Nutritionally induced insulin resistance and receptor defect leading to beta-cell failure in animal models.
Hyperinsulinism
Oleate-induced decrease in hepatocyte insulin binding is mediated by PKC-delta.
Hyperinsulinism
Polymyxin-B suppresses endotoxin-induced insulin hypersecretion in pancreatic islets.
Hyperinsulinism
Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1.
Hyperlipidemias
Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: a DNA microarray study.
Hyperlipidemias
Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus.
Hyperlipidemias
Hyperlipidemia intensifies cerulein-induced acute pancreatitis associated with activation of protein kinase C in rats.
Hyperlipidemias
Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes.
Hyperlipidemias
Lysophosphatidylcholine inhibits insulin-induced Akt activation through protein kinase C-alpha in vascular smooth muscle cells.
Hyperparathyroidism
Regulation of parathyroid hormone release in normal and pathological parathyroid cells exposed to modulators of protein kinase C.
Hypersensitivity
A role for PKCzeta in potentiation of the topoisomerase II activity and etoposide cytotoxicity by wortmannin.
Hypersensitivity
Activation of the RAS/B-RAF-MEK-ERK pathway in satellite glial cells contributes to substance p-mediated orofacial pain.
Hypersensitivity
Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C.
Hypersensitivity
Differential roles of spinal protein kinases C and a in development of primary heat and mechanical hypersensitivity induced by subcutaneous bee venom chemical injury in the rat.
Hypersensitivity
Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance.
Hypersensitivity
Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury.
Hypersensitivity
Impaired phospholipase C activity is involved in the hyperreactivity of platelets in primary hypertension.
Hypersensitivity
Intact subepidermal nerve fibers mediate mechanical hypersensitivity via the activation of protein kinase C gamma in spared nerve injury.
Hypersensitivity
Lamina specific postnatal development of PKC? interneurons within the rat medullary dorsal horn.
Hypersensitivity
Loss of ICA69 Potentiates Long-Lasting Hyperalgesia After Subcutaneous Formalin Injection into the Mouse Hindpaw.
Hypersensitivity
Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain.
Hypersensitivity
Neonatal protein kinase C zeta expression determines the neonatal T-Cell cytokine phenotype and predicts the development and severity of infant allergic disease.
Hypersensitivity
Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat.
Hypersensitivity
Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms.
Hypersensitivity
Phosphorylation-mediated control of chromatin organization and transcriptional activity of the tissue-specific osteocalcin gene.
Hypersensitivity
PKC-Dependent Signaling Pathways within PAG and Thalamus Contribute to the Nitric Oxide-Induced Nociceptive Behavior.
Hypersensitivity
PKC?-positive neurons gate light tactile inputs to pain pathway through pERK1/2 neuronal network in trigeminal neuropathic pain model.
Hypersensitivity
Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1.
Hypersensitivity
Protein kinase C inhibition ameliorates functional endothelial insulin resistance and vascular smooth muscle cell hypersensitivity to insulin in diabetic hypertensive rats.
Hypersensitivity
Protein Kinase C Lambda Mediates Acid-Sensing Ion Channel 1a-Dependent Cortical Synaptic Plasticity and Pain Hypersensitivity.
Hypersensitivity
Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the Rat Stomach.
Hypersensitivity
Protein kinase C-? upregulates sodium channel Nav1.9 in nociceptive dorsal root ganglion neurons in an inflammatory arthritis pain model of rat.
Hypersensitivity
Regulation of the firing activity by PKA-PKC-Src family kinases in cultured neurons of hypothalamic arcuate nucleus.
Hypersensitivity
Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity.
Hypersensitivity
Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain.
Hypersensitivity
Spinal PKC? inhibition and gene-silencing for pain relief: AMPAR trafficking at the synapses between primary afferents and sensory interneurons.
Hypersensitivity
Surgical incision induces phosphorylation of AMPA receptor GluR1 subunits at Serine-831 sites and GluR1 trafficking in spinal cord dorsal horn via a protein kinase C?-dependent mechanism.
Hypersensitivity
The tao of IGF-1: insulin-like growth factor receptor activation increases pain by enhancing T-type calcium channel activity.
Hypersensitivity
TSLP regulates eosinophil migration via phosphorylation of L-plastin in atopic dermatitis.
Hypersensitivity
Vascular Endothelial Growth Factor A Signaling Promotes Spinal Central Sensitization and Pain-related Behaviors in Female Rats with Bone Cancer.
Hypersensitivity, Delayed
On the activity of trifluoperazine and palmitoylcarnitine in mice: delayed hypersensitivity models.
Hypertension
Activation of protein kinase C does not participate in disruption of the blood-brain barrier to albumin during acute hypertension.
Hypertension
Additive effects of hypertension and diabetes on renal cortical expression of PKC-alpha and -epsilon and alpha-tubulin but not PKC-beta 1 and -beta 2.
Hypertension
AKAP150 is required for stuttering persistent Ca2+ sparklets and angiotensin II-induced hypertension.
Hypertension
Alterations of phosphoinositide-specific phospholipase C and protein kinase C in the myocardium of spontaneously hypertensive rats.
Hypertension
Angiotensin II responses after protein kinase C activation in vascular smooth muscle cells of spontaneously hypertensive rats.
Hypertension
Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.
Hypertension
Angiotensin II-dependent hypertension increases Na transport-related oxygen consumption by the thick ascending limb.
Hypertension
Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia.
Hypertension
Ca(2+)-dependent mitogen-activated protein kinase activation in spontaneously hypertensive rat vascular smooth muscle defines a hypertensive signal transduction phenotype.
Hypertension
Calcium and contractile responses to phorbol esters and the calcium channel agonist, Bay K 8644, in arteries from hypertensive rats.
Hypertension
Cardiac protein kinase C expression in two models of cardiac hypertrophy associated with an activated cardiac renin-angiotensin system: effects of experimental hyperthyroidism and genetic hypertension (the mRen-2 rat).
Hypertension
Characterization of the alpha-1 adrenoceptors in the mesenteric vasculature from deoxycorticosterone-salt hypertensive rats: studies on vasoconstriction, radioligand binding and postreceptor events.
Hypertension
Chelerythrine inhibits Na(+)-H+ exchange in platelets from spontaneously hypertensive rats.
Hypertension
Contribution of endogenous endothelin in the enhanced coronary constriction in DOCA-salt hypertensive rats.
Hypertension
Correction of vascular hypercontractility in spontaneously hypertensive rats using shRNAs-induced delta protein kinase C gene silencing.
Hypertension
Correlation analysis of blood pressure and platelet aggregation/vascular reactivity in SHRSP, WKY, F1 and backcross generations.
Hypertension
Dietary omega-3 fatty acids attenuate myocardial arrhythmogenic factors and propensity of the heart to lethal arrhythmias in a rodent model of human essential hypertension.
Hypertension
Effect of protein kinase C activation on cytoskeleton and cation transport in human erythrocytes. Reproduction of some membrane abnormalities revealed in essential hypertension.
Hypertension
Effects of a protein kinase C inhibitor (H-7) on norepinephrine release from vascular adrenergic neurons in spontaneously hypertensive rats.
Hypertension
Enalapril reduces the enhanced 1,2-diacylglycerol content and RNA synthesis in spontaneously hypertensive rat hearts before established hypertension.
Hypertension
Endogenous AT1 receptor-protein kinase C activity in the hypothalamus augments glutamatergic input and sympathetic outflow in hypertension.
Hypertension
Endothelial dysfunction in aortic rings and mesenteric beds isolated from deoxycorticosterone acetate hypertensive rats: possible involvement of protein kinase C.
Hypertension
Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension: comparison with protein kinase C.
Hypertension
Impaired phospholipase C activity is involved in the hyperreactivity of platelets in primary hypertension.
Hypertension
Impaired response to insulin associated with protein kinase C in chronic fructose-induced hypertension.
Hypertension
In vitro and ex vivo antioxidant activities of labetalol on rabbit neutrophil respiratory burst.
Hypertension
Is insulin resistance in the spontaneously hypertensive rat related to changes in protein kinase C in skeletal muscle?
Hypertension
Lipid second messenger regulation: the role of diacylglycerol kinases and their relevance to hypertension.
Hypertension
Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: potential clinical implications in hypertension.
Hypertension
Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension.
Hypertension
Nitric oxide in cyclosporine A-induced hypertension: role of protein kinase C.
Hypertension
Oxidative stress causes renal dopamine D1 receptor dysfunction and hypertension via mechanisms that involve nuclear factor-kappaB and protein kinase C.
Hypertension
Oxidative stress-associated vascular aging is independent of the protein kinase C/NAD(P)H oxidase pathway.
Hypertension
Phorbol-12,13-dibutyrate-induced vasoconstriction in vivo: characterization of response in genetic hypertension.
Hypertension
Phosphorylation of atrial natriuretic factor R1 receptor by serine/threonine protein kinases: evidences for receptor regulation.
Hypertension
PKC-mediated cerebral vasoconstriction: Role of myosin light chain phosphorylation versus actin cytoskeleton reorganization.
Hypertension
Possible involvement of protein kinase C in the maintenance of hypertension in spontaneously hypertensive rats.
Hypertension
Posttranslational effects of protein kinase C and insulin on red cell membrane phosphorylation and cation heteroexchange in hypertension.
Hypertension
Prenatal Testosterone Exposure Induces Hypertension in Adult Females via Androgen Receptor-Dependent Protein Kinase C?-Mediated Mechanism.
Hypertension
Prevention of aortic fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in angiotensin II-induced hypertension.
Hypertension
Protein kinase C activity in erythrocytes in primary hypertension: regulation of cell shape and cation transport.
Hypertension
Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension.
Hypertension
Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension.
Hypertension
Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts.
Hypertension
Protein kinase C-dependent and calmodulin-dependent regulation of neurotransmitter release and vascular responsiveness in spontaneously hypertensive rats.
Hypertension
Regulator of g-protein signaling 5 controls blood pressure homeostasis and vessel wall remodeling.
Hypertension
Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension.
Hypertension
Role of protein kinase C beta in phorbol ester-induced c-fos gene expression in neurons of normotensive and spontaneously hypertensive rat brains.
Hypertension
Role of protein kinase C in Ca channel blocker-induced renal arteriolar dilation in spontaneously hypertensive rats--studies in the isolated perfused hydronephrotic kidney.
Hypertension
Role of protein kinase C in electrical-stimulation-induced neuronal nitric oxide release in mesenteric arteries from hypertensive rats.
Hypertension
Role of protein kinase C in the regulation of acetylcholine release in the central nervous system of spontaneously hypertensive rats.
Hypertension
The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension.
Hypertension
The effect of relaxants working through different transduction mechanisms on the tonic contraction produced in rat aorta by 4 beta-phorbol dibutyrate.
Hypertension
The effects of angiotensin II, endothelin-1, and protein kinase C inhibitor on DNA synthesis and intracellular calcium mobilization in vascular smooth muscle cells from young normotensive and spontaneously hypertensive rats.
Hypertension
The role of protein kinase C and calcium in the regulation of norepinephrine release from the vascular adrenergic neurons in hypertension.
Hypertension
The roles of cell Ca2+, protein kinase C and the Na(+)-H+ antiport in the development of hypertension and insulin resistance.
Hypertension
Three novel sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family.
Hypertension
Tissue-dependent activation of protein kinase C in fructose-induced insulin resistance.
Hypertension
Volume-dependent regulation of cation transport and polyphosphoinositide metabolism in human and rat erythrocytes: features revealed in primary hypertension.
Hypertension
[Changes in erythrocyte volume in relation to characteristics of protein phosphorylation of the membrane cytoskeleton in hypertension: role of protein kinase C]
Hypertension
[Effect of Erigeron breviscapus injection on ventricular and vascular remodeling in spontaneous hypertension rats]
Hypertension
[Effect of inhibiting protein kinase C on calcium sensitivity of contractile apparatus of vascular smooth muscle during vasospasms of different origins]
Hypertension
[Erythrocyte membrane phosphorylation in rats with spontaneous hypertension as affected by protein kinase C activator]
Hypertension
[Fundamental and applied studies on transport and metabolism of electrolytes and glucose--aim to contact with molecular biology]
Hypertension
[Membrane defect in primary arterial hypertension: a reflection of dysfunction of cellular oncogenes?]
Hypertension
[Protein kinase C activity in the brain tissue of spontaneously hypertensive rats]
Hypertension
[Study on the activity of platelets protein kinase C in patients with pregnancy induced hypertension]
Hypertension
[The transcript expression of renal PKC-alpha gene in pregnancy induced hypertension rats].
Hypertension
[Univalent cation transport in human and rat erythrocytes: its regulation by protein kinase activators and compression]
Hypertension, Malignant
ANG II stimulates phospholipase D through PKCzeta activation in VSMC: implications in adhesion, spreading, and hypertrophy.
Hypertension, Portal
Altered prostacyclin synthesis by aortae from hepatic portal vein-constricted rats: evidence for effects on protein kinase C and calcium.
Hypertension, Portal
Role of protein kinase C in mesenteric pressor responses of rats with portal hypertension.
Hypertension, Pregnancy-Induced
[Study on the activity of platelets protein kinase C in patients with pregnancy induced hypertension]
Hypertension, Pregnancy-Induced
[The transcript expression of renal PKC-alpha gene in pregnancy induced hypertension rats].
Hypertension, Pulmonary
Activation of PKCalpha and pulmonary vascular remodelling in broilers.
Hypertension, Pulmonary
Changes in pulmonary arteriole protein kinase calpha expression associated with supplemental L-arginine in broilers during cool temperature exposure.
Hypertension, Pulmonary
Determination of PKC isoform-specific protein expression in pulmonary arteries of rats with chronic hypoxia-induced pulmonary hypertension.
Hypertension, Pulmonary
Polydatin Attenuates Hypoxic Pulmonary Hypertension and Reverses Remodeling through Protein Kinase C Mechanisms.
Hypertension, Pulmonary
Protein kinase C isozyme expression in right ventricular hypertrophy induced by pulmonary hypertension in chronically hypoxic rats.
Hypertension, Pulmonary
Protein kinase C mRNA and protein expressions in hypobaric hypoxia-induced cardiac hypertrophy in rats.
Hypertension, Pulmonary
Role of Protein Kinase C{zeta} and Its Adaptor Protein p62 in Voltage-Gated Potassium Channel Modulation in Pulmonary Arteries.
Hypertension, Pulmonary
The effect of protein kinase C on voltage-gated potassium channel in pulmonary artery smooth muscle cells from rats exposed to chronic hypoxia.
Hypertension, Pulmonary
Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C.
Hypertension, Pulmonary
[Changes of pulmonary artery protein kinase C activity in rats with chronic inflammatory pulmonary hypertension]
Hypertension, Pulmonary
[Effects of hypoxia on the expression of protein kinase C mRNA in pulmonary artery smooth muscle and endothelial cell]
Hypertension, Pulmonary
[The effect of ginkgo biloba on hypoxic pulmonary hypertension and the role of protein kinase C]
Hypertension, Pulmonary
[The increased reactivity of isolated pulmonary artery rings from rats with hypoxia-induced pulmonary hypertension to activator of protein kinase C]
Hypertension, Renal
[Protein kinase A and C activity of erythrocytes in patients with essential hypertension]
Hypertension, Renovascular
Increased NAD(P)H oxidase-mediated superoxide production in renovascular hypertension: evidence for an involvement of protein kinase C.
Hypertensive Encephalopathy
Hypertensive encephalopathy and the blood-brain barrier: is deltaPKC a gatekeeper?
Hypertensive Encephalopathy
Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats.
Hyperthyroidism
Cardiac connexin-43 and PKC signaling in rats with altered thyroid status without and with omega-3 fatty acids intake.
Hyperthyroidism
Cardiac protein kinase C expression in two models of cardiac hypertrophy associated with an activated cardiac renin-angiotensin system: effects of experimental hyperthyroidism and genetic hypertension (the mRen-2 rat).
Hyperthyroidism
Decreased protein kinase C-epsilon expression in hypertrophied cardiac ventricles induced by triiodothyronine treatment in the rat.
Hyperthyroidism
Oxidative Stress Produced by Hyperthyroidism Status Induces the Antioxidant Enzyme Transcription through the Activation of the Nrf-2 Factor in Lymphoid Tissues of Balb/c Mice.
Hypertrophy, Left Ventricular
Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy.
Hypertrophy, Left Ventricular
Phorbol ester stimulates the synthesis and secretion of brain natriuretic peptide from neonatal rat ventricular cardiocytes: a comparison with the regulation of atrial natriuretic factor.
Hypertrophy, Left Ventricular
Protein kinase C activity and expression in rabbit left ventricular hypertrophy.
Hypertrophy, Left Ventricular
Protein kinase C in the human heart: differential regulation of the isoforms in aortic stenosis or dilated cardiomyopathy.
Hypertrophy, Left Ventricular
Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy.
Hypertrophy, Left Ventricular
Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy.
Hypertrophy, Left Ventricular
[Effect of tashinone on nitric oxide synthase in hypertrophic cadiocyte of rats suffered abdominal aorta constriction]
Hypertrophy, Right Ventricular
Differential regulation of cardiac protein kinase C isozyme expression after aortic banding in rat.
Hypertrophy, Right Ventricular
Protein kinase C isozyme expression in right ventricular hypertrophy induced by pulmonary hypertension in chronically hypoxic rats.
Hypertrophy, Right Ventricular
Protein kinase C mRNA and protein expressions in hypobaric hypoxia-induced cardiac hypertrophy in rats.
Hypertrophy, Right Ventricular
Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy.
Hypocalcemia
A novel mutation of the primary protein kinase C phosphorylation site in the calcium-sensing receptor causes autosomal dominant hypocalcemia.
Hypocalcemia
Clinical insights by the presence of bipolar disorder in pseudohypoparathyroidism type 1A.
Hypoglycemia
Brain protein kinase C assay using MARCKS substrate reveals no translocation due to profound insulin-induced hypoglycemia.
Hypoglycemia
Hypoglycemia increases endothelial-dependent vasodilation through suppressing phosphorylation at Threonine 495/497 site of endothelial nitric oxide synthase.
Hypoglycemia
Injury-related factors and conditions down-regulate the thrombin receptor (PAR-1) in a human neuronal cell line.
Hypoglycemia
Phorbol ester alters the electrophysiological responses to hypoxia and ischemic-like conditions in the rat hippocampal slice.
Hypotension
Ca++ influx is essential for the hypotensive response to arginine vasopressin-induced neuron activation of the area postrema in the rat.
Hypotension
Propofol inhibits phorbol 12, 13-dibutyrate-induced, protein kinase C-mediated contraction of rat aortic smooth muscle.
Hypothyroidism
Effect of hypothyroidism and thyroid hormone replacement on the level of protein kinase C and protein kinase A in rat liver.
Hypothyroidism
Influences of hypothyroidism on lipid composition and inositol lipid-linked receptors responsiveness and protein kinase C (PKC) activity in the cerebral cortex of Lewis rats.
Hypothyroidism
Regulation of thyroxine 5'-deiodinase by thyroid hormones and activators of protein kinase C in GH4C1 cells.
Hypothyroidism
Thyroid hormone regulation of RC3, a brain-specific gene encoding a protein kinase-C substrate.
Hypoxia, Brain
Severe withdrawal syndrome in three newborns subjected to continuous opioid infusion and seizure activity dependent on brain hypoxia - ischemia. A possible link.
Ichthyosis, Lamellar
Down-regulation of Langerhans cell protein kinase C-beta isoenzyme expression in inflammatory and hyperplastic dermatoses.
Idiopathic Pulmonary Fibrosis
Increased activity of protein kinase C in alveolar macrophages in idiopathic pulmonary fibrosis.
Idiopathic Pulmonary Fibrosis
[Changes on the protein kinase C activity of alveolar macrophages in patients with idiopathic pulmonary fibrosis]
Ileitis
Inflammation and inflammatory agents activate protein kinase C epsilon translocation and excite guinea-pig submucosal neurons.
Immune System Diseases
PKC Theta Ablation Improves Healing in a Mouse Model of Muscular Dystrophy.
Immune System Diseases
Protein kinase C isozymes as potential therapeutic targets in immune disorders.
Immune System Diseases
Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death.
Infarction, Middle Cerebral Artery
DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo.
Infarction, Middle Cerebral Artery
Generation of a constitutively active fragment of PKN in microglia/macrophages after middle cerebral artery occlusion in rats.
Infarction, Middle Cerebral Artery
Specific induction of protein kinase C delta subspecies after transient middle cerebral artery occlusion in the rat brain: inhibition by MK-801.
Infarction, Middle Cerebral Artery
Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood-Brain Barrier in a Focal Cerebral Ischemic Insult.
Infarction, Middle Cerebral Artery
Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke.
Infarction, Middle Cerebral Artery
Willed-movement training reduces motor deficits and induces a PICK1-dependent LTD in rats subjected to focal cerebral ischemia.
Infections
A proteomic analysis of PKCepsilon targets in astrocytes: implications for astrogliosis.
Infections
A Role for the Non-Canonical Wnt-?-Catenin and TGF-? Signaling Pathways in the Induction of Tolerance during the Establishment of a Salmonella enterica Serovar Enteritidis Persistent Cecal Infection in Chickens.
Infections
Activation and infection of B cells by Epstein-Barr virus. Role of calcium mobilization and of protein kinase C translocation.
Infections
Activation of protein kinase C enhances the infection of endothelial cells by human cytomegalovirus.
Infections
Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment.
Infections
Arabinosylated lipoarabinomannan (Ara-LAM) mediated intracellular mechanisms against tuberculosis infection: Involvement of protein kinase C (PKC) mediated signaling.
Infections
Calcium Influx Caused by ER Stress Inducers Enhances Oncolytic Adenovirus Enadenotucirev Replication and Killing through PKC? Activation.
Infections
CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production.
Infections
Characterization of patterns of expression of protein kinase C-alpha, -delta, -eta, -gamma and -zeta and their correlations to p53, galectin-3, the retinoic acid receptor-beta and the macrophage migration inhibitory factor (MIF) in human cholesteatomas.
Infections
Characterization of the antiviral effects of interferon-alpha against a SARS-like coronoavirus infection in vitro.
Infections
Chitosan inhibits septin-mediated plant infection by the rice blast fungus Magnaporthe oryzae in a protein kinase C and Nox1 NADPH oxidase-dependent manner.
Infections
Differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase C epsilon and delta in neonatal rat ventricular myocytes.
Infections
Differential regulation of Moraxella catarrhalis-induced interleukin-8 response by protein kinase C isoforms.
Infections
Differing roles of protein kinase C-zeta in disruption of tight junction barrier by enteropathogenic and enterohemorrhagic Escherichia coli.
Infections
Distribution of protein kinase C isoforms after infection of macrophages with Leishmania major.
Infections
Downregulation of protein kinase C-alpha enhances intracellular survival of Mycobacteria: role of PknG.
Infections
Echovirus 1 entry into polarized Caco-2 cells depends on dynamin, cholesterol, and cellular factors associated with macropinocytosis.
Infections
Effect of rottlerin, a PKC-delta inhibitor, on TLR-4-dependent activation of murine microglia.
Infections
EGF receptor activation decreases retroviral gene transfer through protein kinase C-delta.
Infections
Encapsulated Streptococcus suis inhibits activation of signaling pathways involved in phagocytosis.
Infections
Enhanced expression of glycine N-methyltransferase by adenovirus-mediated gene transfer in CNS culture is neuroprotective.
Infections
Enigma of HIV-1 latent infection in astrocytes: an in-vitro study using protein kinase C agonist as a latency reversing agent.
Infections
Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability.
Infections
Escherichia coli K-1 interaction with human brain micro-vascular endothelial cells triggers phospholipase C-gamma1 activation downstream of phosphatidylinositol 3-kinase.
Infections
Exogenous and endogenous hyaluronic acid reduces HIV infection of CD4(+) T cells.
Infections
Expression of protein kinase A and protein kinase C during ongoing human cytomegalovirus infection.
Infections
Externalization of host cell protein kinase C during enteropathogenic Escherichia coli infection.
Infections
Ezrin-radixin-moesin family proteins are involved in parvovirus replication and spreading.
Infections
Growth inhibition of herpes simplex virus-type 1 in calphostin C-treated astrocytes.
Infections
Helicobacter pylori activates protein kinase C delta to control Raf in MAP kinase signalling: Role in AGS epithelial cell scattering and elongation.
Infections
Herpes simplex virus type 1 infection induces activation and recruitment of protein kinase C to the nuclear membrane and increased phosphorylation of lamin B.
Infections
Human biliverdin reductase, a previously unknown activator of protein kinase C betaII.
Infections
Identification of novel human kinases that suppress hepatitis C virus infection.
Infections
Immunochemical localization of protein kinase Calpha in the biopsies of human hepatocellular carcinoma.
Infections
Improvement of deficient natural killer activity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro.
Infections
In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase.
Infections
Increased basal contractility of cardiomyocytes overexpressing protein kinase C epsilon and blunted positive inotropic response to endothelin-1.
Infections
Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C delta. Implications for Sindbis virus-induced apoptosis.
Infections
Inhibition of Ehrlichia risticii infection in murine peritoneal macrophages by gamma interferon, a calcium ionophore, and concanavalin A.
Infections
Inhibition of S-phase cyclin-dependent kinase activity blocks expression of Epstein-Barr virus immediate-early and early genes, preventing viral lytic replication.
Infections
Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins.
Infections
Integrin beta and receptor for activated protein kinase C are involved in the cell entry of Bombyx mori cypovirus.
Infections
Interleukin-8-mediated heterologous receptor internalization provides resistance to HIV-1 infectivity. Role of signal strength and receptor desensitization.
Infections
Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C-alpha activation.
Infections
Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp.
Infections
Kaposi's sarcoma-associated herpesvirus induces the phosphatidylinositol 3-kinase-PKC-zeta-MEK-ERK signaling pathway in target cells early during infection: implications for infectivity.
Infections
Kinome analysis of host response to mycobacterial infection: a novel technique in proteomics.
Infections
Leishmania donovani attachment stimulates PKC-mediated oxidative events in bone marrow-derived macrophages.
Infections
Leishmanial protein kinase C modulates host cell infection via secreted acid phosphatase.
Infections
Lipid rafts of primary endothelial cells are essential for Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8-induced phosphatidylinositol 3-kinase and RhoA-GTPases critical for microtubule dynamics and nuclear delivery of viral DNA but dispensable for binding and entry.
Infections
Localization of protein kinase C epsilon to macrophage vacuoles perforated by Listeria monocytogenes cytolysin.
Infections
Macrophage protein kinase C: its role in modulating membrane microviscosity and superoxide in leishmanial infection.
Infections
Macrophage's proinflammatory response to a mycobacterial infection is dependent on sphingosine kinase-mediated activation of phosphatidylinositol phospholipase C, protein kinase C, ERK1/2, and phosphatidylinositol 3-kinase.
Infections
Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35.
Infections
Mechanism of endothelial nitric oxide synthase phosphorylation and activation by thrombin.
Infections
Modulation of protein kinase C activity in Plasmodium falciparum-infected erythrocytes.
Infections
MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C.
Infections
New perspectives on PKCtheta, a member of the novel subfamily of protein kinase C.
Infections
Novel PKCeta is required to activate replicative functions of the major nonstructural protein NS1 of minute virus of mice.
Infections
Outer membrane protein A expression in Enterobacter sakazakii is required to induce microtubule condensation in human brain microvascular endothelial cells for invasion.
Infections
Parvovirus interference with intracellular signalling: mechanism of PKCeta activation in MVM-infected A9 fibroblasts.
Infections
Phosphorylation of canine distemper virus P protein by protein kinase C-zeta and casein kinase II.
Infections
PKC zeta participates in activation of inflammatory response induced by enteropathogenic E. coli.
Infections
PKC-? isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-?B and CXCL8 production.
Infections
PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice.
Infections
Platelet-activating factor (PAF) modulates peritoneal mouse macrophage infection by Leishmania amazonensis.
Infections
Platelet-activating factor enhances complement-dependent phagocytosis of diamide-treated erythrocytes by human monocytes through activation of protein kinase C and phosphorylation of complement receptor type one (CR1).
Infections
Productive Entry of Foot-and-Mouth Disease Virus via Macropinocytosis Independent of Phosphatidylinositol 3-Kinase.
Infections
Protein kinase C activation and vacuolation in HeLa cells invaded by Mycoplasma penetrans.
Infections
Protein kinase C and NF-?B-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection.
Infections
Protein kinase C isozymes regulate matrix metalloproteinase-1 expression and cell invasion in Helicobacter pylori infection.
Infections
Protein Kinase C Mediates Enterohemorrhagic Escherichia coli O157:H7-Induced Attaching and Effacing Lesions.
Infections
Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2.
Infections
Protein kinase C-alpha activity is required for respiratory syncytial virus fusion to human bronchial epithelial cells.
Infections
Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1.
Infections
Protein kinase C-zeta is critical in pancreatitis-induced apoptosis of Kupffer cells.
Infections
Protein kinase Calpha and sphingosine 1-phosphate-dependent signaling in endothelial cell.
Infections
Protein kinase Cdelta functions downstream of Ca2+ mobilization in FcepsilonRI signaling to degranulation in mast cells.
Infections
Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes.
Infections
Proteomic analysis reveals a role for protein kinase C-alpha in phagosome maturation.
Infections
Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury.
Infections
Puerarin Attenuates High Glucose and Diabetes-induced Vascular Smooth Muscle Cell Proliferation Via Blocking PKC-beta2/Rac-1-Dependent Signaling.
Infections
Rac and protein kinase C-delta regulate ERKs and cytosolic phospholipase A2 in FcepsilonRI signaling to cysteinyl leukotriene synthesis in mast cells.
Infections
Reactivation of Kaposi's sarcoma-associated herpesvirus from latency requires MEK/ERK, JNK and p38 multiple mitogen-activated protein kinase pathways.
Infections
Reduced susceptibility to HIV-1 infection of ethyl-methanesulfonate-treated CEM subclones correlates with a blockade in their protein kinase C signaling pathway.
Infections
Regulation of impaired protein kinase C signaling by chemokines in murine macrophages during visceral leishmaniasis.
Infections
Regulatory effects of persistent measles virus infection on tumorigenicity and protooncogene expression in neuroblastoma cells.
Infections
Rescuing Infertility of Pick1 Knockout Mice by Generating Testis-specific Transgenic Mice via Testicular Infection.
Infections
Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon.
Infections
Rift Valley fever virus strain MP-12 enters mammalian host cells via caveola-mediated endocytosis.
Infections
Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice.
Infections
Role of protein kinase C in cytokine secretion by lung epithelial cells during infection with Paracoccidioides brasiliensis.
Infections
Role of protein kinase C-alpha in the control of infection by intracellular pathogens in macrophages.
Infections
Salmon cells SHK-1 internalize infectious pancreatic necrosis virus by macropinocytosis.
Infections
Sodium stibogluconate (Pentostam) potentiates oxidant production in murine visceral leishmaniasis and in human blood.
Infections
Spatial and temporal proteome dynamics of glioma cells during oncolytic adenovirus Delta-24-RGD infection.
Infections
Spring viraemia of carp virus enters grass carp ovary cells via clathrin-mediated endocytosis and macropinocytosis.
Infections
Suramin, an anti-cancer drug, inhibits protein kinase C and induces differentiation in neuroblastoma cell clone NB2A.
Infections
Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma-associated herpesvirus.
Infections
The Host GTPase Arf1 and Its Effectors AP1 and PICK1 Stimulate Actin Polymerization and Exocytosis To Promote Entry of Listeria monocytogenes.
Infections
The role of free oxygen radicals in the expulsion of primary infections of Nippostrongylus brasiliensis.
Infections
The Role of Tyrosine Phosphorylation of Protein Kinase C Delta in Infection and Inflammation.
Infections
Transforming growth factor beta1 ameliorates intestinal epithelial barrier disruption by Cryptosporidium parvum in vitro in the absence of mucosal T lymphocytes.
Infections
Trichinella spiralis infection enhances protein kinase C phosphorylation in guinea pig alveolar macrophages.
Infections
Ubiquitination Participates in the Lysosomal Degradation of the Na,K-ATPase in Steady-State Conditions.
Infections
Viral interference with neuronal integrity: what can we learn from the Borna disease virus?
Infections
Viral persistent infection affects both transcriptional and posttranscriptional regulation of neuron-specific molecule GAP43.
Infections
Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells.
Infertility
Rescuing Infertility of Pick1 Knockout Mice by Generating Testis-specific Transgenic Mice via Testicular Infection.
Infertility, Male
ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
Infertility, Male
PICK1 deficiency causes male infertility in mice by disrupting acrosome formation.
Infertility, Male
Rescuing Infertility of Pick1 Knockout Mice by Generating Testis-specific Transgenic Mice via Testicular Infection.
Inflammatory Bowel Diseases
Activation of delta-isoform of protein kinase C is required for oxidant-induced disruption of both the microtubule cytoskeleton and permeability barrier of intestinal epithelia.
Inflammatory Bowel Diseases
Protein kinase C theta plays a fundamental role in different types of chronic colitis.
Inflammatory Bowel Diseases
Small molecule inhibitors of PKCTheta as potential antiinflammatory therapeutics.
Influenza, Human
A nutritional supplement formula for influenza A (H5N1) infection in humans.
Influenza, Human
Characterization of a protein kinase C-delta (PKC-delta) ATP binding mutant. An inactive enzyme that competitively inhibits wild type PKC-delta enzymatic activity.
Influenza, Human
Entry of influenza viruses into cells is inhibited by a highly specific protein kinase C inhibitor.
Influenza, Human
Influenza virus hemagglutinin stimulates the protein kinase C activity of human polymorphonuclear leucocytes.
Influenza, Human
Influenza virus inhibits amiloride-sensitive Na+ channels in respiratory epithelia.
Influenza, Human
Influenza virus recruits host protein kinase C to control assembly and activity of its replication machinery.
Influenza, Human
Inhibitory effect of protein kinase C inhibitor on the replication of influenza type A virus.
Influenza, Human
Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus.
Influenza, Human
Modulation of influenza virus replication by alteration of sodium ion transport and protein kinase C activity.
Influenza, Human
Reversible penetration of alpha-glutathione S-transferase into biological membranes revealed by photosensitized labelling in situ.
Influenza, Human
Role of G protein and protein kinase signalling in influenza virus budding in MDCK cells.
Influenza, Human
Role of protein kinase C betaII in influenza virus entry via late endosomes.
Influenza, Human
The influenza A virus M1 protein interacts with the cellular receptor of activated C kinase (RACK) 1 and can be phosphorylated by protein kinase C.
Influenza, Human
The influenza A virus proteins PB1 and NS1 are subject to functionally important phosphorylation by protein kinase C.
Insulin Resistance
A bis-Schiff base of isatin improves methylglyoxal mediated insulin resistance in skeletal muscle cells.
Insulin Resistance
A brief history of insulin resistance: from the first insulin radioimmunoassay to selectively targeting protein kinase C pathways.
Insulin Resistance
A high-fructose diet impairs Akt and PKCzeta phosphorylation and GLUT4 translocation in rat skeletal muscle.
Insulin Resistance
Abrogating Monoacylglycerol Acyltransferase Activity in Liver Improves Glucose Tolerance and Hepatic Insulin Signaling in Obese Mice.
Insulin Resistance
Activation of Vascular Protein Kinase C-{beta} Inhibits Akt-Dependent Endothelial Nitric Oxide Synthase Function in Obesity-Associated Insulin Resistance.
Insulin Resistance
Acute reversal of lipid-induced muscle insulin resistance is associated with rapid alteration in PKC-theta localization.
Insulin Resistance
Albert Renold memorial lecture: molecular background of nutritionally induced insulin resistance leading to type 2 diabetes--from animal models to humans.
Insulin Resistance
Alcohol and the cardiovascular system research challenges and opportunities.
Insulin Resistance
Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat.
Insulin Resistance
Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity.
Insulin Resistance
AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome.
Insulin Resistance
Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications.
Insulin Resistance
BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1? in livers of obese and type 2 diabetic humans.
Insulin Resistance
Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus: overexpression of protein kinase Cepsilon in skeletal muscle precedes the onset of hyperinsulinemia and hyperglycemia.
Insulin Resistance
Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation.
Insulin Resistance
Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis.
Insulin Resistance
Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women.
Insulin Resistance
Classical PKC is not associated with defective insulin signaling in patients with impaired glucose tolerance.
Insulin Resistance
Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance.
Insulin Resistance
Complementary measures for promoting insulin sensitivity in skeletal muscle.
Insulin Resistance
Considering the Links Between Nonalcoholic Fatty Liver Disease and Insulin Resistance: Revisiting the Role of Protein Kinase C ?.
Insulin Resistance
CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance.
Insulin Resistance
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Insulin Resistance
De novo synthesis of diacylglycerol in endothelium may mediate the association between PAI-1 and the insulin resistance syndrome.
Insulin Resistance
Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3,4,5,-(PO(4))(3) in Obesity and Polycystic Ovary Syndrome.
Insulin Resistance
DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation.
Insulin Resistance
Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance.
Insulin Resistance
Disruption of the murine protein kinase Cbeta gene promotes gallstone formation and alters biliary lipid and hepatic cholesterol metabolism.
Insulin Resistance
Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta.
Insulin Resistance
Does Diacylglycerol Accumulation in Fatty Liver Disease Cause Hepatic Insulin Resistance?
Insulin Resistance
Early growth restriction leads to down regulation of protein kinase C zeta and insulin resistance in skeletal muscle.
Insulin Resistance
Effect of dehydroepiandrosterone on insulin sensitivity in Otsuka Long-Evans Tokushima-fatty rats.
Insulin Resistance
Effect of insulin and insulin-like growth factors I and II on phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate breakdown in liver from humans with and without type II diabetes.
Insulin Resistance
Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp.
Insulin Resistance
Effects of knockout of the protein kinase C beta gene on glucose transport and glucose homeostasis.
Insulin Resistance
Effects of tumor necrosis factor-alpha on insulin stimulated amino acid transport in cultured rat hepatocytes.
Insulin Resistance
Effects of tumour necrosis factor-alpha and inhibition of protein kinase C on glucose uptake in L6 myoblasts.
Insulin Resistance
Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain.
Insulin Resistance
Enhanced stimulation of diacylglycerol and lipid synthesis by insulin in denervated muscle. Altered protein kinase C activity and possible link to insulin resistance.
Insulin Resistance
Essential role of protein kinase C zeta in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes.
Insulin Resistance
Expression of the major isoenzyme of protein kinase-C in skeletal muscle, nPKC theta, varies with muscle type and in response to fructose-induced insulin resistance.
Insulin Resistance
Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).
Insulin Resistance
Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta.
Insulin Resistance
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
Insulin Resistance
Free fatty acids induce endothelial dysfunction and activate protein kinase C and nuclear factor-kappaB pathway in rat aorta.
Insulin Resistance
Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance.
Insulin Resistance
Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis.
Insulin Resistance
Glucocorticoid-induced insulin resistance associates with activation of protein kinase C isoforms.
Insulin Resistance
Glycerol-3-phosphate acyltransferase 1-deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity.
Insulin Resistance
Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus.
Insulin Resistance
Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.
Insulin Resistance
Identification of a major defect in insulin-resistant tissues of genetically obese (fa/fa) rats. Impaired protein kinase C.
Insulin Resistance
In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs.
Insulin Resistance
In vivo effects of polyunsaturated, monounsaturated, and saturated fatty acids on hepatic and peripheral insulin sensitivity.
Insulin Resistance
Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice.
Insulin Resistance
Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes.
Insulin Resistance
Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle.
Insulin Resistance
Increased skeletal muscle expression of PKC-theta but not PKC-alpha mRNA in type 2 diabetes: inverse relationship with in-vivo insulin sensitivity.
Insulin Resistance
Inflammatory biomarkers as a part of diagnosis in diabetic peripheral neuropathy.
Insulin Resistance
Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances ?-cell function of obese Zucker rats.
Insulin Resistance
Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes.
Insulin Resistance
Inhibition of insulin signaling and glycogen synthesis by phorbol dibutyrate in rat skeletal muscle.
Insulin Resistance
Inhibition of lipolysis by ilexgenin A via AMPK activation contributes to the prevention of hepatic insulin resistance.
Insulin Resistance
Inhibition of PKCbeta improves glucocorticoid-induced insulin resistance in rat adipocytes.
Insulin Resistance
Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease.
Insulin Resistance
Inhibitory effect of ceramide on insulin-induced protein kinase Czeta translocation in rat adipocytes.
Insulin Resistance
Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3' kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance.
Insulin Resistance
Insulin sensitivity is related to fat oxidation and protein kinase C activity in children with acute burn injury.
Insulin Resistance
Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair.
Insulin Resistance
Insulin-activated protein kinase Cbeta bypasses Ras and stimulates mitogen-activated protein kinase activity and cell proliferation in muscle cells.
Insulin Resistance
Insulin-stimulated glucose transport in muscle. Evidence for a protein-kinase-C-dependent component which is unaltered in insulin-resistant mice.
Insulin Resistance
Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity.
Insulin Resistance
Is insulin resistance in the spontaneously hypertensive rat related to changes in protein kinase C in skeletal muscle?
Insulin Resistance
Is prenatal myo-inositol deficiency a mechanism of CNS injury in galactosemia?
Insulin Resistance
Links between enhanced fatty acid flux, protein kinase C and NFkappaB activation, and apoB-lipoprotein production in the fructose-fed hamster model of insulin resistance.
Insulin Resistance
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha.
Insulin Resistance
Long-term pioglitazone treatment augments insulin sensitivity and PKC-epsilon and PKC-theta activation in skeletal muscles in sucrose fed rats.
Insulin Resistance
Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity.
Insulin Resistance
Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes.
Insulin Resistance
Maternal protein restriction affects postnatal growth and the expression of key proteins involved in lifespan regulation in mice.
Insulin Resistance
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.
Insulin Resistance
Mechanisms of insulin resistance and new pharmacological approaches to metabolism and diabetic complications.
Insulin Resistance
Mechanisms underlying the onset of oral lipid-induced skeletal muscle insulin resistance in humans.
Insulin Resistance
Metabolic responses to high-fat diets rich in n-3 or n-6 long-chain polyunsaturated fatty acids in mice selected for either high body weight or leanness explain different health outcomes.
Insulin Resistance
Minimal effects of phorbol esters on glucose transport and insulin sensitivity of rat skeletal muscle.
Insulin Resistance
Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance.
Insulin Resistance
Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta.
Insulin Resistance
Molecular and cellular mechanisms linking inflammation to insulin resistance and ?-cell dysfunction.
Insulin Resistance
Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction.
Insulin Resistance
Monounsaturated fatty acids are required for membrane translocation of protein kinase C-theta induced by lipid overload in skeletal muscle.
Insulin Resistance
Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat.
Insulin Resistance
Nelfinavir-induced insulin resistance is associated with impaired plasma membrane recruitment of the PI 3-kinase effectors Akt/PKB and PKC-zeta.
Insulin Resistance
New perspectives on PKCtheta, a member of the novel subfamily of protein kinase C.
Insulin Resistance
Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling.
Insulin Resistance
Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling.
Insulin Resistance
Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes.
Insulin Resistance
Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C ? and ?.
Insulin Resistance
Pancreastatin inhibitor activates AMPK pathway via GRP78 and ameliorates dexamethasone induced fatty liver disease in C57BL/6 mice.
Insulin Resistance
Phorbol esters affect skeletal muscle glucose transport in a fiber type-specific manner.
Insulin Resistance
Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells.
Insulin Resistance
pkc-1 regulates daf-2 insulin/IGF signalling-dependent control of dauer formation in Caenorhabditis elegans.
Insulin Resistance
PKC-? is essential for pancreatic beta cell replication during insulin resistance by regulating mTOR and cyclin-D2.
Insulin Resistance
PKCepsilon induces interleukin-6 expression through the MAPK pathway in 3T3-L1 adipocytes.
Insulin Resistance
PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance.
Insulin Resistance
Potential Nexus of Non-alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Insulin Resistance Between Hepatic and Peripheral Tissues.
Insulin Resistance
Prenatal and postnatal pathways to obesity: different underlying mechanisms, different metabolic outcomes.
Insulin Resistance
Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance.
Insulin Resistance
Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells.
Insulin Resistance
Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes.
Insulin Resistance
Protein kinase C and lipid-induced insulin resistance in skeletal muscle.
Insulin Resistance
Protein kinase C inhibition ameliorates functional endothelial insulin resistance and vascular smooth muscle cell hypersensitivity to insulin in diabetic hypertensive rats.
Insulin Resistance
Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells).
Insulin Resistance
Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states.
Insulin Resistance
Protein kinase C isoforms: mediators of reactive lipid metabolites in the development of insulin resistance.
Insulin Resistance
Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.
Insulin Resistance
Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance.
Insulin Resistance
Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteries.
Insulin Resistance
Protein kinase Ctheta expression is increased upon differentiation of human skeletal muscle cells: dysregulation in type 2 diabetic patients and a possible role for protein kinase Ctheta in insulin-stimulated glycogen synthase activity.
Insulin Resistance
Protein kinases C: potential targets for intervention in diabetic nephropathy.
Insulin Resistance
Renoprotective and blood pressure-lowering effect of dietary soy protein via protein kinase C betaII inhibition in a rat model of metabolic syndrome.
Insulin Resistance
Reversal of chronic alterations of skeletal muscle protein kinase C from fat-fed rats by BRL-49653.
Insulin Resistance
Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler.
Insulin Resistance
Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance.
Insulin Resistance
Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells.
Insulin Resistance
Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.
Insulin Resistance
Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.
Insulin Resistance
Suppression of free fatty acid-induced insulin resistance by phytopolyphenols in C2C12 mouse skeletal muscle cells.
Insulin Resistance
The Impact of Substance P on the Pathogenesis of Insulin Resistance Leading to Gestational Diabetes.
Insulin Resistance
The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling.
Insulin Resistance
The role of atypical and conventional PKC in dehydroepiandrosterone-induced glucose uptake and dexamethasone-induced insulin resistance.
Insulin Resistance
The roles of cell Ca2+, protein kinase C and the Na(+)-H+ antiport in the development of hypertension and insulin resistance.
Insulin Resistance
Tissue-dependent activation of protein kinase C in fructose-induced insulin resistance.
Insulin Resistance
Tracing the footsteps of glomerular insulin signaling in diabetic kidney disease.
Insulin Resistance
Transcriptional regulation of insulin receptor substrate 1 by protein kinase C.
Insulin Resistance
[Effects of calcium channel blockers in atherosclerosis and cardiovascular event and oxidative vascular damage]
Insulinoma
Activation of PKC inhibits NaF-induced inositol phospholipid turnover in rat insulinoma cells.
Insulinoma
Dual action of protein kinase C activation in the regulation of insulin release by muscarinic agonist from rat insulinoma cell line (RINr).
Insulinoma
Effect of estradiol on insulin secreting INS-1 cells overexpressing estrogen receptors.
Insulinoma
Effect of protein kinase C on glucose-mediated insulin secretion in HIT-T15 cells.
Insulinoma
Effects of secretagogues on insulin biosynthesis and secretion in polyamine-depleted pancreatic beta-cells.
Insulinoma
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Insulinoma
Expression, intracellular localization, and gene transcription regulation of the secretory protein 7B2 in endocrine pancreatic cell lines and human insulinomas.
Insulinoma
Glucose- and phorbol ester-induced insulin secretion in human insulinoma cells--association with protein kinase C activation.
Insulinoma
Identification and subcellular characterization of protein kinase-C isoforms in insulinoma beta-cells and whole islets.
Insulinoma
Involvement of protein kinase C in the phosphorylation of an insulin-granule membrane protein.
Insulinoma
Phosphorylation of nonmuscle myosin heavy chain IIA on Ser1917 is mediated by protein kinase C beta II and coincides with the onset of stimulated degranulation of RBL-2H3 mast cells.
Insulinoma
PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system.
Insulinoma
Regulation of ATP-sensitive K+ channels in insulinoma cells: activation by somatostatin and protein kinase C and the role of cAMP.
Insulinoma
Regulation of glucagon-like peptide-I receptor expression and transcription by the protein kinase C pathway.
Insulinoma
Up-regulation of L- and non-L, non-N-type Ca2+ channels by basal and stimulated protein kinase C activation in insulin-secreting RINm5F cells.
Intellectual Disability
The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking.
Intervertebral Disc Degeneration
Calcitonin inhibits intervertebral disc degeneration by regulating protein kinase C.
Intervertebral Disc Degeneration
CK8 phosphorylation induced by compressive loads underlies the downregulation of CK8 in human disc degeneration by activating protein kinase C.
Intervertebral Disc Displacement
PKC? signalling activates ERK1/2, and regulates aggrecan, ADAMTS5, and miR377 gene expression in human nucleus pulposus cells.
Intestinal Neoplasms
PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1.
Intestinal Neoplasms
Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance.
Iron Deficiencies
Impaired protein kinase C activation as one of the possible mechanisms of reduced lymphocyte proliferation in iron deficiency in mice.
Iron Deficiencies
In vivo and in vitro iron deficiency reduces protein kinase C activity and translocation in murine splenic and purified T cells.
Ischemic Attack, Transient
Increased phosphorylation of the NR1 subunit of the NMDA receptor following cerebral ischemia.
Ischemic Attack, Transient
Inhibition of protein kinase C reduces ischemia-induced tyrosine phosphorylation of the N-methyl-d-aspartate receptor.
Ischemic Attack, Transient
Post- and presynaptic lesions in the CA1 region of hippocampus: effect on [3H]forskolin and [3H]phorboldibutyrate ester binding.
Ischemic Attack, Transient
Post-ischemic changes in protein kinase C RNA in the gerbil brain following prolonged periods of recirculation: a phosphorimaging study.
Ischemic Attack, Transient
Protein kinase C-like immunoreactivity in gerbil hippocampus after a transient cerebral ischemia.
Ischemic Attack, Transient
Regional alterations of protein kinase C activity following transient cerebral ischemia: effects of intraischemic brain temperature modulation.
Ischemic Stroke
Association between 1425G/A SNP in PRKCH and ischemic stroke among Chinese and Japanese populations: a meta-analysis including 3686 cases and 4589 controls.
Ischemic Stroke
Common mechanisms of Alzheimer's disease and ischemic stroke: the role of protein kinase C in the progression of age-related neurodegeneration.
Ischemic Stroke
cPKC? alleviates ischemic injury through modulating synapsin Ia/b phosphorylation in neurons of mice.
Ischemic Stroke
Impact of the 1425G/A Polymorphism of PRKCH on the Recurrence of Ischemic Stroke: Fukuoka Stroke Registry.
Ischemic Stroke
Protein kinase C expression and activity in the human brain after ischaemic stroke.
Ischemic Stroke
Suppression of PKC-? attenuates TNF-?-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen-plasmin system.
Ischemic Stroke
The 1425G/A SNP in PRKCH is associated with ischemic stroke and cerebral hemorrhage in a Chinese population.
Ischemic Stroke
The SNP (rs2230500) in PRKCH decreases the risk of carotid intima-media thickness in a Chinese young adult population.
Keloid
Keloid fibroblasts are refractory to inhibition of DNA synthesis by phorbol esters. Altered response is accompanied by reduced sensitivity to prostaglandin E2 and altered down-regulation of phorbol ester binding sites.
Keloid
PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts.
Keloid
Suppression of protein kinase C and the stimulation of glucocorticoid receptor synthesis by dexamethasone in human fibroblasts derived from tumor tissue.
Keratosis, Seborrheic
Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases.
Kidney Diseases
PKC-{delta} Promotes Renal Tubular Cell Apoptosis Associated with Proteinuria.
Kidney Neoplasms
A multicentre phase II trial of bryostatin-1 in patients with advanced renal cancer.
Kidney Neoplasms
Inhibition of PKC? reduces the ability of migration of kidney cancer cells but has no impact on cell apoptosis.
Kidney Neoplasms
PKC?/midkine pathway drives hypoxia-induced proliferation and differentiation of human lung epithelial cells.
Kidney Neoplasms
Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer.
Kidney Neoplasms
Regulation of beta1 integrin expression by PKCepsilon in renal cancer cells.
Kidney Neoplasms
Role of insulin receptor substrates and protein kinase C-zeta in vascular permeability factor/vascular endothelial growth factor expression in pancreatic cancer cells.
Kidney Neoplasms
Tumor necrosis factor mediates apoptosis via Ca++/Mg++ dependent endonuclease with protein kinase C as a possible mechanism for cytokine resistance in human renal carcinoma cells.
Kidney Neoplasms
Upregulation of MARCKS in kidney cancer and its potential as a therapeutic target.
Lambert-Eaton Myasthenic Syndrome
Clinical implications of basic neuroscience research. I: Protein kinases, ionic channels, and genes.
Laminopathies
Protein Kinase C Alpha Cellular Distribution, Activity, and Proximity with Lamin A/C in Striated Muscle Laminopathies.
Laryngeal Neoplasms
[Multidrug resistance increase of tumor cells at the effect of radiation and phorbol ether depends on protein kinase C and reactive oxygen species]
Latent Infection
An HIV-1 replication pathway utilizing reverse transcript products that fail to integrate.
Latent Infection
Enigma of HIV-1 latent infection in astrocytes: an in-vitro study using protein kinase C agonist as a latency reversing agent.
Legionnaires' Disease
PKC{alpha} and {epsilon} differentially regulate Legionella pneumophila induced GM-CSF.
Legionnaires' Disease
Role of protein kinase C-alpha in the control of infection by intracellular pathogens in macrophages.
Leiomyoma
DOG1 Utility in diagnosing gastrointestinal stromal tumors on fine-needle aspiration.
Leiomyoma
Human uterine smooth muscle and leiomyoma cells differ in their rapid 17beta-estradiol signaling: implications for proliferation.
Leiomyoma
Involvement of annexin V in the antiproliferative effect of GnRH agonist on cultured human uterine leiomyoma cells.
Leiomyoma
Potentiation response of cultured human uterine leiomyoma cells to various growth factors by endothelin-1: role of protein kinase C.
Leiomyoma
Specificity of DOG1 (K9 clone) and protein kinase C theta (clone 27) as immunohistochemical markers of gastrointestinal stromal tumour.
Leiomyosarcoma
DOG1 Utility in diagnosing gastrointestinal stromal tumors on fine-needle aspiration.
Leishmaniasis
Distribution of protein kinase C isoforms after infection of macrophages with Leishmania major.
Leishmaniasis
Induction of host protective Th1 immune response by chemokines in Leishmania donovani-infected BALB/c mice.
Leishmaniasis
MARCKS-related protein (MRP) is a substrate for the Leishmania major surface protease leishmanolysin (gp63).
Leishmaniasis
TLR2 dimer-specific ligands selectively activate protein kinase C isoforms in Leishmania infection.
Leishmaniasis, Visceral
Amphotericin B regulates the host immune response in visceral leishmaniasis: reciprocal regulation of protein kinase C isoforms.
Leishmaniasis, Visceral
Immunosuppression in hamsters with progressive visceral leishmaniasis is associated with an impairment of protein kinase C activity in their lymphocytes that can be partially reversed by okadaic acid or anti-transforming growth factor beta antibody.
Leishmaniasis, Visceral
MAPK-directed phosphatases preferentially regulate pro- and anti-inflammatory cytokines in experimental visceral leishmaniasis: involvement of distinct protein kinase C isoforms.
Leishmaniasis, Visceral
Regulation of impaired protein kinase C signaling by chemokines in murine macrophages during visceral leishmaniasis.
Leishmaniasis, Visceral
The curative effect of fucoidan on visceral leishmaniasis is mediated by activation of MAP kinases through specific protein kinase C isoforms.
Leukemia
12-O-tetradecanoyl phorbol 13-acetate, protein kinase C (PKC) activator, protects human leukemia HL-60 cells from taxol-induced apoptosis: possible role for extracellular signal-regulated kinase.
Leukemia
12-o-Tetradecanoylphorbol 13-acetate prevents baicalein-induced apoptosis via activation of protein kinase C and JNKs in human leukemia cells.
Leukemia
A new inhibitor of protein kinase C, RK-1409B (4'-demethylamino-4'-hydroxy-3'-epistaurosporine).
Leukemia
Activation of human leukemia protein kinase C by tumor promoters and its inhibition by N-trifluoroacetyladriamycin-14-valerate (AD 32).
Leukemia
Activation of membrane-bound phospholipase D by protein kinase C in HL60 cells: synergistic action of a small GTP-binding protein RhoA.
Leukemia
Activation of protein kinase C in rat basophilic leukemia cells stimulates increased production of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: correlation with actin polymerization.
Leukemia
Activation of protein kinase C induces nuclear translocation of RFX1 and down-regulates c-myc via an intron 1 X box in undifferentiated leukemia HL-60 cells.
Leukemia
Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells.
Leukemia
Adriamycin interacts with diacylglycerol to inhibit human leukemia protein kinase C.
Leukemia
Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2.
Leukemia
Akt and PKC are involved not only in upregulation of telomerase activity but also in cell differentiation-related function via mTORC2 in leukemia cells.
Leukemia
AMP-activated protein kinase mediates T cell activation-induced expression of FasL and COX-2 via protein kinase C theta-dependent pathway in human Jurkat T leukemia cells.
Leukemia
Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C.
Leukemia
Anticancer drug-mediated induction of multidrug resistance-associated genes and protein kinase C isozymes in the T-lymphoblastoid cell line CCRF-CEM and in blasts from patients with acute lymphoblastic leukemias.
Leukemia
Antigen-induced secretion of histamine and the phosphorylation of myosin by protein kinase C in rat basophilic leukemia cells.
Leukemia
Antigen-mediated phospholipase D activation in rat basophilic leukemia (RBL-2H3) cells: possible involvement of calcium/calmodulin.
Leukemia
Arachidonic acid release by basophilic leukemia cells and macrophages stimulated by Ca2+ ionophores, antigen and diacylglycerol: essential role for protein kinase C and prevention by glucocorticosteroids.
Leukemia
Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells.
Leukemia
Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis.
Leukemia
Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter.
Leukemia
Bistratene A: a novel compound causing changes in protein phosphorylation patterns in human leukemia cells.
Leukemia
Bryostatin 1 increases 1-beta-D-arabinofuranosylcytosine-induced cytochrome c release and apoptosis in human leukemia cells ectopically expressing Bcl-x(L).
Leukemia
Bryostatin induces changes in protein kinase C location and activity without altering c-myc gene expression in human promyelocytic leukemia cells (HL-60).
Leukemia
Bryostatin induces protein kinase C modulation, Mcl-1 up-regulation and phosphorylation of Bcl-2 resulting in cellular differentiation and resistance to drug-induced apoptosis in B-cell chronic lymphocytic leukemia cells.
Leukemia
Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin.
Leukemia
Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis.
Leukemia
Chemical modification of santonin into a diacetoxy acetal form confers the ability to induce differentiation of human promyelocytic leukemia cells via the down-regulation of NF-kappaB DNA binding activity.
Leukemia
Cooperative interactions of protein kinase C and cAMP-dependent protein kinase systems in human promyelocytic leukemia HL60 cells.
Leukemia
Corrigendum to "AMP-activated protein kinase mediates T cell activation-induced expression of FasL and COX-2 via protein kinase C theta-dependent pathway in human Jurkat T leukemia cells" [Cell. Signal. 24 (2012) 1195-1207].
Leukemia
Cremophor EL inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced protein phosphorylation in human myeloblastic leukemia ML-1 cells.
Leukemia
Cudraflavanone A purified from Cudrania tricuspidata induces apoptotic cell death of human leukemia U937 cells, at least in part, through the inhibition of DNA topoisomerase I and protein kinase C activity.
Leukemia
Cyclic adenosine monophosphate inhibits nitric oxide-induced apoptosis in human leukemic HL-60 cells.
Leukemia
Cytokine-cytokine synergy and protein kinase C in the regulation of lung fibroblast leukemia inhibitory factor.
Leukemia
Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells.
Leukemia
Different effects of the two protein kinase C activators bryostatin-1 and TPA on growth and differentiation of human monocytic leukemia cell lines.
Leukemia
Differential effects of the MDR1 (multidrug resistance) gene-activating agents on protein kinase C: evidence for redundancy of mechanisms of acquired MDR in leukemia cells.
Leukemia
Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.
Leukemia
Differential involvement of protein kinase C in human promyelocytic leukemia cell differentiation enhanced by artemisinin.
Leukemia
Differential regulation of protein kinase C isoenzymes during sphinganine potentiation of retinoic acid-induced granulocytic differentiation in human leukemia HL-60 cells.
Leukemia
Differential regulation of protein kinase C subspecies in human promyelocytic leukemia cell line HL-60 during differentiation induced by retinoic acid.
Leukemia
Differential requirements for p21ras and protein kinase C in the regulation of neuronal gene expression by nerve growth factor and neurokines.
Leukemia
Disparate effects of activators of protein kinase C on HL-60 promyelocytic leukemia cell differentiation.
Leukemia
Dissociation of protein kinase C activation from phorbol ester-induced maturation of HL-60 leukemia cells.
Leukemia
Docosahexaenoic acid induces increases in [Ca2+]i via inositol 1,4,5-triphosphate production and activates protein kinase C gamma and -delta via phosphatidylserine binding site: implication in apoptosis in U937 cells.
Leukemia
dsDNA-stimulated phosphorylation of a 72-kDa nucleoprotein accompanies PMA-induced HL-60 leukemic cell differentiation.
Leukemia
Effect of 12-deoxyphorbol 13-phenylacetate on daunorubicin resistance and calcium-independent protein-kinase-C isozymes in drug-sensitive murine leukemia p388 cells.
Leukemia
Effect of an inhibitory factor for protein kinase C on cell growth of leukemic cells.
Leukemia
Effect of bryostatin 1 on taxol-induced apoptosis and cytotoxicity in human leukemia cells (U937).
Leukemia
Effects of azidothymidine on protein kinase C activity and expression in erythroleukemic cell K562 and acute lymphoblastic leukemia cell HSB-2.
Leukemia
Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[beta-D-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells.
Leukemia
Effects of hydroquinone-type and phenolic antioxidants on calcium signals and degranulation of RBL-2H3 cells.
Leukemia
Effects of inducers of differentiation on protein kinase C and CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase activities of HL-60 leukemia cells.
Leukemia
Effects of inhibitors of protein kinase C on the release and synthesis of histamine in rat basophilic leukemia cells (2H3).
Leukemia
Effects of the protein kinase C inhibitor H-7 and calmodulin antagonist W-7 on superoxide production in growing and resting human histiocytic leukemia cells (U937).
Leukemia
Effects of thioether phospholipid BM 41.440 on protein kinase C and phorbol ester-induced differentiation of human leukemia HL60 and KG-1 cells.
Leukemia
Elevation of intracellular calcium ion by prostaglandin E1 and its inhibition by protein kinase C in a human megakaryocyte leukemia cell line.
Leukemia
Enhanced gene expression of the murine ecotropic retroviral receptor and its human homolog in proliferating cells.
Leukemia
Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling.
Leukemia
Evidence that activation of MEK1,2/erk1,2 signal transduction pathway is necessary for calcitriol-induced differentiation of HL-60 cells.
Leukemia
Expression of GTP-binding proteins and protein kinase C isozymes in platelet-like particles derived from megakaryoblastic leukemia cells (MEG-01).
Leukemia
Expression of protein kinase C-beta promotes the stimulatory effect of phorbol ester on phosphatidylethanolamine synthesis.
Leukemia
Frontline Science: Tumor necrosis factor-? stimulation and priming of human neutrophil granule exocytosis.
Leukemia
Granulocyte-macrophage colony-stimulating factor rescues TF-1 leukemia cells from ionizing radiation-induced apoptosis through a pathway mediated by protein kinase Calpha.
Leukemia
Human leukemia K562 cell mutant (K562/OA200) selected for resistance to okadaic acid (protein phosphatase inhibitor) lacks protein kinase C-epsilon, exhibits multidrug resistance phenotype, and expresses drug pump P-glycoprotein.
Leukemia
Hypophosphorylation of topoisomerase II in etoposide (VP-16)-resistant human leukemia K562 cells associated with reduced levels of beta II protein kinase C.
Leukemia
Immunochemical evidence that three protein kinase C isozymes increase in abundance during HL-60 differentiation induced by dimethyl sulfoxide and retinoic acid.
Leukemia
In vivo administration of bryostatin 1, a protein kinase C activator, decreases murine resistance to Salmonella typhimurium.
Leukemia
Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells.
Leukemia
Induction of apoptosis by Se-MSC in U937 human leukemia cells through release of cytochrome c and activation of caspases and PKC-delta: mutual regulation between caspases and PKC-delta via a positive feedback mechanism.
Leukemia
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C.
Leukemia
Induction of human promyelocytic leukemia HL-60 cell differentiation into monocytes by silibinin: involvement of protein kinase C.
Leukemia
Induction of smg p21/rap1A p21/krev-1 p21 gene expression during phorbol ester-induced differentiation of a human megakaryocytic leukemia cell line.
Leukemia
Inhibition of chemotactic peptide-induced phosphoinositide hydrolysis by phorbol esters through the activation of protein kinase C in differentiated human leukemia (HL-60) cells.
Leukemia
Inhibition of Na,K-ATPase and sodium pump by protein kinase C regulators sphingosine, lysophosphatidylcholine, and oleic acid.
Leukemia
Inhibition of protein kinase C activator-mediated induction of p21CIP1 and p27KIP1 by deoxycytidine analogs in human leukemia cells: relationship to apoptosis and differentiation.
Leukemia
Inhibition of protein kinase C, (sodium plus potassium)-activated adenosine triphosphatase, and sodium pump by synthetic phospholipid analogues.
Leukemia
Involvement of diverse protein kinase C isoforms in the differentiation of ML-1 human myeloblastic leukemia cells induced by the vitamin D3 analogue KH1060 and the phorbol ester TPA.
Leukemia
Involvement of PKC and ROS in the cytotoxic mechanism of anti-leukemic decursin and its derivatives and their structure-activity relationship in human K562 erythroleukemia and U937 myeloleukemia cells.
Leukemia
Involvement of PKC betaII in anti-proliferating action of a new antitumor compound gnidimacrin.
Leukemia
Involvement of protein kinase C during activation of the mitogen-activated protein kinase cascade by leukemia inhibitory factor. Evidence for participation of multiple signaling pathways.
Leukemia
Involvement of two intracellular messenger systems, protein kinase C and cyclic AMP, in the regulation of c-fos gene expression in human promyelocytic leukemia (HL-60) cells.
Leukemia
Isolation and characterization of a variant HL60 cell line defective in the activation of the NADPH oxidase by phorbol myristate acetate.
Leukemia
Isolation and purification of protein kinase C from human leukemia ML-1 cells phosphorylation of human leukemia RNA polymerase II in vitro.
Leukemia
Lamin B phosphorylation by protein kinase calpha and proteolysis during apoptosis in human leukemia HL60 cells.
Leukemia
Leukotriene D4-induced activation of protein kinase C in rat basophilic leukemia cells.
Leukemia
Membrane interactions of mastoparan analogues related to their differential effects on protein kinase C, Na, K-ATPase and HL60 cells.
Leukemia
Microarray and proteomics analyses of human intestinal epithelial cells treated with the Aeromonas hydrophila cytotoxic enterotoxin.
Leukemia
Microbial extracellular glycolipid induction of differentiation and inhibition of the protein kinase C activity of human promyelocytic leukemia cell line HL60.
Leukemia
Mitochondrial anchoring of PKCalpha by PICK1 confers resistance to etoposide-induced apoptosis.
Leukemia
Modulation by phorbol 12-myristate 13-acetate of arachidonic acid release from rat basophilic leukemia cells stimulated with A23187.
Leukemia
Modulation of protein kinase C and Ca2+ lipid-independent protein kinase in lymphoma induced by Moloney murine leukemia virus in BALB/c mice.
Leukemia
Modulation of retinoic acid-induced differentiation of human leukemia (HL-60) cells by serum factors and sphinganine.
Leukemia
Modulation of the expression of Bcl-2 and related proteins in human leukemia cells by protein kinase C activators: relationship to effects on 1-[beta-D-arabinofuranosyl]cytosine-induced apoptosis.
Leukemia
NF-kappaB or AP-1-dependent reporter gene expression is not altered in human U937 cells exposed to power-line frequency magnetic fields.
Leukemia
Novobiocin- and phorbol-12-myristate-13-acetate-induced differentiation of human leukemia cells associated with a reduction in topoisomerase II activity.
Leukemia
Okadaic acid increased annexin I and induced differentiation of human promyelocytic leukemia cells.
Leukemia
Opposing regulatory effects of protein kinase C on the cAMP cascade in human HL-60 promyelocytic leukemia cells.
Leukemia
Overexpression of protein kinase Czeta confers protection against antileukemic drugs by inhibiting the redox-dependent sphingomyelinase activation.
Leukemia
Overexpression of the atypical protein kinase C zeta reduces topoisomerase II catalytic activity, cleavable complexes formation, and drug-induced cytotoxicity in monocytic U937 leukemia cells.
Leukemia
PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.
Leukemia
Phase I trial and correlative laboratory studies of bryostatin 1 (NSC 339555) and high-dose 1-B-D-arabinofuranosylcytosine in patients with refractory acute leukemia.
Leukemia
Phenylarsine oxide (PAO)-mediated activation of phospholipase D in rat basophilic leukemia (RBL-2H3) cells: possible involvement of calcium and protein kinase C.
Leukemia
Phorbol diester-induced alterations in the expression of protein kinase C isozymes and their mRNAs. Analysis in wild-type and phorbol diester-resistant HL-60 cell clones.
Leukemia
Phorbol ester (TPA)-induced differential modulation of cell surface antigens in human pluripotential leukemia (K-562) cell line: effects of protein kinase inhibitors with broad- and PKC selective inhibitory activity.
Leukemia
Phorbol ester inhibits DNA damage-induced apoptosis in U937 cells through activation of protein kinase C.
Leukemia
Phorbol myristate acetate-differentiated THP-1 cells display increased levels of MHC class I and class II mRNA and interferon-gamma-inducible tumoricidal activity.
Leukemia
Phospholipase C activates protein kinase C and induces monocytic differentiation of HL-60 cells.
Leukemia
Phospholipase C-induced monocytic differentiation in a human monocytic leukemia cell line THP-1.
Leukemia
PI 3-K signaling pathway suppresses PMA-induced expression of p21WAF1/Cip1 in human leukemia cells.
Leukemia
PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation.
Leukemia
PKC eta directs induction of IRF-4 expression and Ig kappa gene rearrangement in pre-BCR signaling pathway.
Leukemia
PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia.
Leukemia
PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice.
Leukemia
Potentiation of ara-C-induced apoptosis by the protein kinase C activator bryostatin 1 in human leukemia cells (HL-60) involves a process dependent upon c-Myc.
Leukemia
Potentiation of the activity of 1-beta-D-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells: association with enhanced fragmentation of mature DNA.
Leukemia
Potentiation of the activity of nitric oxide by the protein kinase C activator phorbol ester in human myeloid leukemic HL-60 cells: association with enhanced fragmentation of mature genomic DNA.
Leukemia
Presence of a beta II protein kinase C-selective nuclear membrane activation factor in human leukemia cells.
Leukemia
Pro-survival role of protein kinase C epsilon in Philadelphia chromosome positive acute leukemia.
Leukemia
Protein kinase C activation and protooncogene expression in differentiation/retrodifferentiation of human U-937 leukemia cells.
Leukemia
Protein kinase C activators of the teleocidin family decrease the IgE-binding capacity of rat basophilic leukemia cells.
Leukemia
Protein kinase C activities with different characteristics, including substrate specificity, from two human HL-60 leukemia cell variants.
Leukemia
Protein kinase C activity during sphinganine potentiation of retinoic acid-induced differentiation in a human leukemia cell line (HL-60).
Leukemia
Protein kinase C activity in human leukemia cell lines with reference to sensitivity to antineoplastic agents.
Leukemia
Protein kinase C beta from Friend erythroleukemia cells is associated with chromatin and DNA.
Leukemia
Protein kinase C beta gene expression is associated with susceptibility of human promyelocytic leukemia cells to phorbol ester-induced differentiation.
Leukemia
Protein kinase C during differentiation of human promyelocytic leukemia cell line, HL-60.
Leukemia
Protein kinase C in the promyelocytic leukemia cell differentiation of granulocytes.
Leukemia
Protein kinase C is not necessary for transforming growth factor beta-induced growth-arrest in leukemia cell lines.
Leukemia
Protein kinase C isozymes in human megakaryoblastic leukemia cell line, MEG-01: possible involvement of the isozymes in the differentiation process of MEG-01 cells.
Leukemia
Protein kinase C-beta is required for macrophage differentiation of human HL-60 leukemia cells.
Leukemia
Protein kinases C-beta and C-epsilon link the mast cell high-affinity receptor for IgE to the expression of c-fos and c-jun.
Leukemia
Quantitative analysis of CD5 antigen modulation by 12-O-tetradecanoylphorbol-13-acetate in T-lymphoblastic leukemia cells: individual response patterns and their relationships with both maturation and protein kinase C content.
Leukemia
Quaternary ammonium analogs of ether lipids inhibit the activation of protein kinase C and the growth of human leukemia cell lines.
Leukemia
Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways.
Leukemia
Rapid down-regulation of protein kinase C and membrane association in phorbol ester-treated leukemia cells.
Leukemia
Regulation of c-jun gene expression in HL-60 leukemia cells by 1-beta-D-arabinofuranosylcytosine. Potential involvement of a protein kinase C dependent mechanism.
Leukemia
Regulation of sphingosine kinase 1 gene expression by protein kinase C in a human leukemia cell line, MEG-O1.
Leukemia
Regulation of the antigen-induced F-actin response in rat basophilic leukemia cells by protein kinase C.
Leukemia
Relation of protein kinase A and protein kinase C to signaling pathways of hematopoietic factors in leukemia cell lines.
Leukemia
Retinoic acid promotes phorbol ester-initiated macrophage differentiation in HL-60 leukemia cells without disappearance of protein kinase C.
Leukemia
Retinoic acid-specific induction of a protein kinase C isoform during differentiation of HL-60 cells.
Leukemia
Role of protein kinase C activators and inhibitors, calmodulin antagonists and membrane sialic acids in polyamine transport in murine leukemia cells.
Leukemia
Role of protein kinase C in phosphorylation of vinculin in adriamycin-resistant HL-60 leukemia cells.
Leukemia
Role of the Ca2+/phosphatidylserine binding region of the C2 domain in the translocation of protein kinase Calpha to the plasma membrane.
Leukemia
Selective low level of protein kinase C isozyme in a tumor promoter-dependent mouse leukemia cell line.
Leukemia
Specificities of acylglycerols and phospholipids for interaction with phorbol ester receptor on Friend leukemia cells.
Leukemia
Sphinganine potentiation of dimethyl sulfoxide-induced granulocyte differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60).
Leukemia
Sphingosine induces apoptosis in androgen-independent human prostatic carcinoma DU-145 cells by suppression of bcl-X(L) gene expression.
Leukemia
Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp.
Leukemia
Staurosporine inhibits protein kinase C and prevents phorbol ester-mediated leukotriene D4 receptor desensitization in RBL-1 cells.
Leukemia
Stimulation of 1-(beta-D-arabinofuranosyl)cytosine (AraC)-induced apoptosis in the multidrug resistant human promyelocytic leukemia cell lines with protein kinase inhibitors.
Leukemia
Stimulation of phosphoinositol turnover and protein kinase C activation by granulocyte-macrophage colony-stimulating factor in HL-60 cells.
Leukemia
Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
Leukemia
Studies of protein kinase C in the rat basophilic leukemia (RBL-2H3) cell reveal that antigen-induced signals are not mimicked by the actions of phorbol myristate acetate and Ca2+ ionophore.
Leukemia
Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells.
Leukemia
Studies on the relationship between protein kinase C and differentiation of human promyelocytic leukemia cells induced by retinoic acid.
Leukemia
Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.
Leukemia
Synergistic effect of PKC activation and actin filament disruption on carbonate apatite-facilitated lymphocyte transfection.
Leukemia
Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.
Leukemia
Synergistic stimulating effect between cyclic AMP and phorbol ester on plasminogen activator inhibitor type 2 production in human promyelocytic leukemia cell line PL-21.
Leukemia
Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
Leukemia
Synthesis of oxygenated cholesterols as structural mimics of phorbol ester-type tumor promoters.
Leukemia
Synthetic analogues (indolactams) of (-)-indolactam-V are new congeners of the teleocidin class of tumor promoters.
Leukemia
T cell activation via the CD2 molecule is associated with protein kinase C translocation from the cytosol to the plasma membrane.
Leukemia
Temporal changes in intracellular distribution of protein kinase C during differentiation of human leukemia HL60 cells induced by phorbol ester.
Leukemia
The cholinergic stimulating effects of ciliary neurotrophic factor and leukemia inhibitory factor are mediated by protein kinase C.
Leukemia
The effect of staurosporine on drug-induced, topoisomerase II-mediated DNA cleavage in human leukemia cells.
Leukemia
The protein kinase C inhibitor H7 blocks phosphorylation of stathmin during TPA-induced growth inhibition of human pre-B leukemia REH6 cells.
Leukemia
The rise in concentration of free Ca2+ and of pH provides sequential, synergistic signals for secretion in antigen-stimulated rat basophilic leukemia (RBL-2H3) cells.
Leukemia
Thrombin-induced translocation of protein kinase C in human megakaryoblastic leukemia cells (MEG-01).
Leukemia
Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation.
Leukemia
Translocation of protein kinase C in human leukemia cells susceptible or resistant to differentiation induced by phorbol 12-myristate 13-acetate.
Leukemia
Tumor-promoting activity of staurosporine, a protein kinase inhibitor on mouse skin.
Leukemia
Unique in vitro and in vivo thrombopoietic activities of ingenol 3,20 dibenzoate, a Ca(++)-independent protein kinase C isoform agonist.
Leukemia
[A laboratory and clinical study of induced differentiation therapy by all trans-retinoic acid in acute promyelocytic leukemia]
Leukemia
[Effects of protein tyrosine kinase, protein tyrosine phosphatase and protein kinase C on the apoptosis of arsenic trioxide treated NB4 cells and human cortex neurons]
Leukemia
[The involvement of protein kinase C isozymes in activation of phospholipase D and secretion of serotonin in rat basophilic leukemia cells]
Leukemia P388
Expression of protein-kinase-C isozymes in multidrug-resistant murine leukemia p388/adr cells.
Leukemia, Erythroblastic, Acute
4-Hydroxynonenal-induced MEL cell differentiation involves PKC activity translocation.
Leukemia, Erythroblastic, Acute
A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity.
Leukemia, Erythroblastic, Acute
A rise and fall in 1,2-diacylglycerol content signal hexamethylene bisacetamide-induced erythropoiesis.
Leukemia, Erythroblastic, Acute
Changes in protein kinase C activity are associated with the differentiation of Friend erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Co-ordinate expression of activin A and its type I receptor mRNAs during phorbol ester-induced differentiation of human K562 erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Correlation between levels of delta protein kinase C and resistance to differentiation in murine erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Dexniguldipine hydrochloride, a protein-kinase-C-specific inhibitor, affects the cell cycle, differentiation, P-glycoprotein levels, and nuclear protein phosphorylation in Friend erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Differential expression of protein kinase C isoform genes in three murine erythroleukemia cell variants: implication for chemical induced differentiation.
Leukemia, Erythroblastic, Acute
Differential expression of protein kinase C isozymes and erythroleukemia cell differentiation.
Leukemia, Erythroblastic, Acute
Differential modulation of protein kinase C isoforms in erythroleukemia during induced differentiation.
Leukemia, Erythroblastic, Acute
dl-alpha-tocopherol, a potent inhibitor of phorbol ester induced shape change of erythro- and megakaryoblastic leukemia cells.
Leukemia, Erythroblastic, Acute
Dual mitochondrial localization and different roles of the reversible reaction of mammalian ferrochelatase.
Leukemia, Erythroblastic, Acute
Effects of calcium, calmodulin, protein kinase C and protein tyrosine kinases on volume-activated taurine efflux in human erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Engagement of PI-3-kinase mediated protein kinase C zeta activation in protecting Friend cells from ionizing radiation-induced apoptosis.
Leukemia, Erythroblastic, Acute
Enhanced expression of the beta II subspecies of protein kinase C in differentiating erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Enhanced gene expression of the murine ecotropic retroviral receptor and its human homolog in proliferating cells.
Leukemia, Erythroblastic, Acute
Evidence that a novel human differentiation-inhibiting protein blocks the dimethyl sulfoxide-induced differentiation of erythroleukemia cells by inhibiting the activation of membrane protein kinase C.
Leukemia, Erythroblastic, Acute
Expression and modulation of protein kinase C isoforms in differentiation-competent and differentiation-resistant erythroleukemic cells.
Leukemia, Erythroblastic, Acute
Identification and functional characterization of protein kinase C isozymes in platelets and HEL cells.
Leukemia, Erythroblastic, Acute
Identification of a protein kinase C activating factor from murine erythroleukemia cells: characterization of the activation kinetics.
Leukemia, Erythroblastic, Acute
In vitro phosphorylation of lamin B by protein kinase C in friend erythroleukemia. Effect of chemically induced differentiation.
Leukemia, Erythroblastic, Acute
Induction of leukotriene C4 synthase activity in differentiating human erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Introduction of the beta isozyme of protein kinase C accelerates induced differentiation of murine erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Involvement of nuclear PLCbeta1 in lamin B1 phosphorylation and G2/M cell cycle progression.
Leukemia, Erythroblastic, Acute
Involvement of PKC in TPA-potentiated apoptosis induction during hemin-mediated erythroid differentiation in K562 cells.
Leukemia, Erythroblastic, Acute
Mapping of a molecular determinant for protein kinase C betaII isozyme function.
Leukemia, Erythroblastic, Acute
Maturation of murine erythroleukemia cells committed to differentiation requires protein kinase C.
Leukemia, Erythroblastic, Acute
Modulation of the intracellular Ca(2+)-dependent proteolytic system is critically correlated with the kinetics of differentiation of murine erythroleukemia cells.
Leukemia, Erythroblastic, Acute
NF-kappaB/RelA transactivation is required for atypical protein kinase C iota-mediated cell survival.
Leukemia, Erythroblastic, Acute
Nuclear protein kinase C activity is decreased in Friend erythroleukemia cells induced to differentiate.
Leukemia, Erythroblastic, Acute
Phosphatidylinositol-3-kinase activation and atypical protein kinase C zeta phosphorylation characterize the DMSO signalling in erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Protein kinase C activity and hexamethylenebisacetamide-induced erythroleukemia cell differentiation.
Leukemia, Erythroblastic, Acute
Protein kinase C beta from Friend erythroleukemia cells is associated with chromatin and DNA.
Leukemia, Erythroblastic, Acute
Protein kinase C isoforms in murine erythroleukemia cells and their involvement in the differentiation process.
Leukemia, Erythroblastic, Acute
Protein kinase C isotypes in human erythroleukemia (K562) cell proliferation and differentiation. Evidence that beta II protein kinase C is required for proliferation.
Leukemia, Erythroblastic, Acute
Protein kinase C isotypes in human erythroleukemia cell proliferation and differentiation.
Leukemia, Erythroblastic, Acute
Protein kinase C isozymes epsilon and alpha in murine erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Protein kinase C zeta nuclear translocation mediates the occurrence of radioresistance in friend erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Protein kinase C-epsilon is necessary for erythropoietin's up-regulation of c-myc and for factor-dependent DNA synthesis. Evidence for discrete signals for growth and differentiation.
Leukemia, Erythroblastic, Acute
Protein kinase calpha is an effector of hexamethylene bisacetamide-induced differentiation of Friend erythroleukemia cells.
Leukemia, Erythroblastic, Acute
The activation of inactive membrane-associated protein kinase C is associated with DMSO-induced erythroleukemia cell differentiation.
Leukemia, Lymphocytic, Chronic, B-Cell
Bryostatin induces protein kinase C modulation, Mcl-1 up-regulation and phosphorylation of Bcl-2 resulting in cellular differentiation and resistance to drug-induced apoptosis in B-cell chronic lymphocytic leukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Expression of three major protein kinase C isozymes in various types of human leukemic cells.
Leukemia, Lymphocytic, Chronic, B-Cell
High-affinity interleukin 2 receptors on B cell chronic lymphocytic leukemia cells are induced by phorbol myristate acetate but not by calcium ionophore.
Leukemia, Lymphocytic, Chronic, B-Cell
Induction of differentiation of B-cell leukemia cell lines JVM-2 and EHEB by bryostatin 1.
Leukemia, Lymphocytic, Chronic, B-Cell
Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Phosphorylation of the MARCKS family of protein kinase C substrates in human B chronic lymphocytic leukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Protein kinase C expression is deregulated in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Protein Kinase C isoform expression in chronic lymphocytic leukemia: a potential target for therapy?
Leukemia, Lymphocytic, Chronic, B-Cell
Recruitment of PKC-betaII to lipid rafts mediates apoptosis-resistance in chronic lymphocytic leukemia expressing ZAP-70.
Leukemia, Lymphocytic, Chronic, B-Cell
Successful treatment of human chronic lymphocytic leukemia xenografts with combination biological agents auristatin PE and bryostatin 1.
Leukemia, Lymphocytic, Chronic, B-Cell
Survival role of protein kinase C (PKC) in chronic lymphocytic leukemia and determination of isoform expression pattern and genes altered by PKC inhibition.
Leukemia, Lymphoid
Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro.
Leukemia, Lymphoid
Characterization and purification of a protein kinase C substrate in human B cells. Identification as lymphocyte-specific protein 1 (LSP1).
Leukemia, Lymphoid
Differential expression of TRAP Isoenzyme in B-CLL Cells Treated with Different Inducers.
Leukemia, Lymphoid
Effect of TPA on fructose 2,6-bisphosphate levels and protein kinase C activity in B-chronic lymphocytic leukemia (B-CLL).
Leukemia, Lymphoid
Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp.
Leukemia, Megakaryoblastic, Acute
Inhibition by Rho-kinase and protein kinase C of myosin phosphatase is involved in thrombin-induced shape change of megakaryocytic leukemia cell line UT-7/TPO.
Leukemia, Monocytic, Acute
Pivotal Advance: PKC{zeta} is required for migration of macrophages.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Altered erythrocyte protein kinase C activity and membrane protein phosphorylation in chronic myelogenous leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Differentiation and growth modulation of chronic myelogenous leukemia cells by bryostatin.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein kinase C deficiency in juvenile chronic myeloid leukemia: a case report.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein kinase C isoforms in normal and leukemic neutrophils: altered levels in leukemic neutrophils and changes during myeloid maturation in chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Role of protein kinase C-delta (PKC-delta) in the generation of the effects of IFN-alpha in chronic myelogenous leukemia cells.
Leukemia, Myeloid
1-beta-D-arabinofuranosylcytosine activates serine/threonine protein kinases and c-jun gene expression in phorbol ester-resistant myeloid leukemia cells.
Leukemia, Myeloid
Activation of PKCalpha downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL60 cells.
Leukemia, Myeloid
Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells.
Leukemia, Myeloid
Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2.
Leukemia, Myeloid
Bryostatin 1 enhances paclitaxel-induced mitochondrial dysfunction and apoptosis in human leukemia cells (U937) ectopically expressing Bcl-xL.
Leukemia, Myeloid
Characterization of a relationship between the T-lymphocyte derived differentiation inducing factor (DIF) and lymphotoxin: a common receptor system for DIF, lymphotoxin and tumor necrosis factor downregulated by phorbol diesters.
Leukemia, Myeloid
Control of interleukin-1 beta expression by protein kinase C and cyclic adenosine monophosphate in myeloid leukemia cells.
Leukemia, Myeloid
Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation.
Leukemia, Myeloid
Different regulation of plasminogen activator inhibitor 2 gene expression by phorbol ester and cAMP in human myeloid leukemia cell line PL-21.
Leukemia, Myeloid
Differential responsiveness to phorbol esters correlates with differential expression of protein kinase C in KG-1 and KG-1a human myeloid leukemia cells.
Leukemia, Myeloid
Differentiation and growth modulation of myeloid leukemia cells by the protein kinase C activating agent bryostatin-1.
Leukemia, Myeloid
Effect of AS101 on bryostatin 1-mediated differentiation induction, cell cycle arrest, and modulation of drug-induced apoptosis in human myeloid leukemia cells.
Leukemia, Myeloid
Effects of phorbol ester on translocation and down-regulation of protein kinase C and phosphorylation of endogenous proteins in human acute myeloid leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.
Leukemia, Myeloid
Functional role for protein kinase Cbeta as a regulator of stress-activated protein kinase activation and monocytic differentiation of myeloid leukemia cells.
Leukemia, Myeloid
Implication of protein kinase C in the regulation of DNA mismatch repair protein expression and function.
Leukemia, Myeloid
Inactive caspase 3 activates Akt in human leukemia cells susceptible or resistant to apoptosis induced by phorbol ester.
Leukemia, Myeloid
Induction of morphological change of human myeloid leukemia and activation of protein kinase C by a novel antibiotic, tautomycin.
Leukemia, Myeloid
Induction of tumor necrosis factor by bryostatin 1 is involved in synergistic interactions with paclitaxel in human myeloid leukemia cells.
Leukemia, Myeloid
Inhibition of phorbol ester-induced monocytic differentiation by dexamethasone is associated with down-regulation of c-fos and c-jun (AP-1).
Leukemia, Myeloid
Inhibition of protein kinase C is associated with a decrease in c-myc expression in human myeloid leukemia cells.
Leukemia, Myeloid
Long-wave ultraviolet radiation causes increase of membrane-bound fraction of protein kinase C in rat myeloid leukemia cells.
Leukemia, Myeloid
Modulation of 1-[beta-D-arabinofuranosyl] cytosine-induced apoptosis in human myeloid leukemia cells by staurosporine and other pharmacological inhibitors of protein kinase C.
Leukemia, Myeloid
Modulation of protein kinase C activity and calcium-sensitive isoform expression in human myeloid leukemia cells by bryostatin 1: relationship to differentiation and ara-C-induced apoptosis.
Leukemia, Myeloid
Monoclonal antibodies to the human CSF-1 receptor (c-fms proto-oncogene product) detect epitopes on normal mononuclear phagocytes and on human myeloid leukemic blast cells.
Leukemia, Myeloid
Phorbol ester-induced generation of reactive oxygen species is protein kinase cbeta -dependent and required for SAPK activation.
Leukemia, Myeloid
Protein kinase C activation modulates pro- and anti-apoptotic signaling pathways.
Leukemia, Myeloid
Protein kinase C-dependent activation of the tumor necrosis factor receptor-mediated extrinsic cell death pathway underlies enhanced apoptosis in human myeloid leukemia cells exposed to bryostatin 1 and flavopiridol.
Leukemia, Myeloid
Protein kinase Ciota activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis.
Leukemia, Myeloid
Regulation of cell cycle and apoptosis by protein kinase C in rat myeloid leukemia cell line.
Leukemia, Myeloid
Relation of protein kinase A and protein kinase C to signaling pathways of hematopoietic factors in leukemia cell lines.
Leukemia, Myeloid
Requirement for caspase activation in monocytic differentiation of myeloid leukemia cells.
Leukemia, Myeloid
Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C.
Leukemia, Myeloid
Synergistic effect of AS101 and Bryostatin-1 on myeloid leukemia cell differentiation in vitro and in an animal model.
Leukemia, Myeloid
The effects of the broadband UVA radiation on myeloid leukemia cells: the possible role of protein kinase C in mediation of UVA-induced effects.
Leukemia, Myeloid
The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents.
Leukemia, Myeloid, Acute
BAX and PKCalpha modulate the prognostic impact of BCL2 expression in acute myelogenous leukemia.
Leukemia, Myeloid, Acute
Bryostatin 1: a potential anti-leukemic agent for chronic myelomonocytic leukemia.
Leukemia, Myeloid, Acute
Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.
Leukemia, Myeloid, Acute
Effect of a combined exposure to cytosine arabinoside, bryostatin 1, and recombinant granulocyte-macrophage colony-stimulating factor on the clonogenic growth in vitro of normal and leukemic human hematopoietic progenitor cells.
Leukemia, Myeloid, Acute
Effects of phorbol ester on translocation and down-regulation of protein kinase C and phosphorylation of endogenous proteins in human acute myeloid leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.
Leukemia, Myeloid, Acute
Expression of PKC isozyme and MDR-associated genes in primary and relapsed state AML.
Leukemia, Myeloid, Acute
Expression of three major protein kinase C isozymes in various types of human leukemic cells.
Leukemia, Myeloid, Acute
PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.
Leukemia, Myeloid, Acute
Protein kinase C alpha-mediated phosphorylation of PIM-1L promotes the survival and proliferation of acute myeloid leukemia cells.
Leukemia, Myeloid, Acute
Protein Kinase C Epsilon Is a Key Regulator of Mitochondrial Redox Homeostasis in Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Protein Kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: Involvement in apoptosis induction.
Leukemia, Myeloid, Acute
Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy.
Leukemia, Myeloid, Acute
Synergistic effect of all?trans retinoic acid in combination with protein kinase C 412 in FMS-like tyrosine kinase 3-mutated acute myeloid leukemia cells.
Leukemia, Myeloid, Acute
T cells remaining after intensive chemotherapy for acute myelogenous leukemia show a broad cytokine release profile including high levels of interferon-gamma that can be further increased by a novel protein kinase C agonist PEP005.
Leukemia, Myeloid, Acute
Targeting PKC mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid Leukemia-Derived cell lines and blast cells.
Leukemia, Myeloid, Acute
Tetraspanin CD82 drives acute myeloid leukemia chemoresistance by modulating protein kinase C alpha and ?1 integrin activation.
Leukemia, Myeloid, Acute
The Novel Phospholipid Mimetic KPC34 Is Highly Active Against Acute Myeloid Leukemia with Activated Protein Kinase C.
Leukemia, Myeloid, Acute
Treosulfan-induced apoptosis in acute myeloid leukemia cells is accompanied by translocation of protein kinase C delta and enhanced by bryostatin-1.
Leukemia, Promyelocytic, Acute
Activation of protein kinase C delta by all-trans-retinoic acid.
Leukemia, Promyelocytic, Acute
Protein kinase C in the promyelocytic leukemia cell differentiation of granulocytes.
Leukemia, Promyelocytic, Acute
[A laboratory and clinical study of induced differentiation therapy by all trans-retinoic acid in acute promyelocytic leukemia]
Leukemia, T-Cell
Activation of protein kinase C inhibits prostaglandin- and potentiates adenosine receptor-stimulated accumulation of cyclic AMP in a human T-cell leukemia line.
Leukemia, T-Cell
Dual effects of protein kinase-C on receptor-stimulated cAMP accumulation in a human T-cell leukemia line.
Leukemia, T-Cell
PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia.
Leukemia, T-Cell
Protein kinase C theta cooperates with Vav1 to induce JNK activity in T-cells.
Leukemia, T-Cell
Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C.
Leukemia, T-Cell
The TCL1 oncoprotein inhibits activation-induced cell death by impairing PKCtheta and ERK pathways.
Leukemia-Lymphoma, Adult T-Cell
Altered expression of protein kinase C in adult T-cell leukemia cells.
Leukodystrophy, Globoid Cell
Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses.
Leukostasis
Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation.
Leukostasis
Importance of pericytes and mechanisms of pericyte loss during diabetes retinopathy.
Lipid Metabolism Disorders
[The role of lipid metabolism disorders, atypical isoforms of protein kinase C, and mutational status of cytosolic and mitochondrial forms of isocitrate dehydrogenase in carcinogenesis of glial tumors].
Liver Cirrhosis
Angiotensin-II induces the tissue inhibitor of metalloproteinases-1 through the protein kinase-C signaling pathway in rat liver fibrosis development.
Liver Cirrhosis
PKC? Mediates NF-?B Inflammatory Response and Downregulates SIRT1 Expression in Liver Fibrosis.
Liver Cirrhosis
Resveratrol prevents liver fibrosis via two possible pathways: Modulation of alpha fetoprotein transcriptional levels and normalization of protein kinase C responses.
Liver Cirrhosis
Subcellular redistribution of protein kinase C isozymes is associated with rat liver cirrhotic changes induced by carbon tetrachloride or thioacetamide.
Liver Diseases
Abnormal hepatocystin caused by truncating PRKCSH mutations leads to autosomal dominant polycystic liver disease.
Liver Diseases
An in vitro model of polycystic liver disease using genome-edited human inducible pluripotent stem cells.
Liver Diseases
Autosomal dominant polycystic liver disease in a family without polycystic kidney disease associated with a novel missense protein kinase C substrate 80K-H mutation.
Liver Diseases
Considering the Links Between Nonalcoholic Fatty Liver Disease and Insulin Resistance: Revisiting the Role of Protein Kinase C ?.
Liver Diseases
Lipid metabolism, oxidative stress and cell death are regulated by PKC delta in a dietary model of nonalcoholic steatohepatitis.
Liver Diseases
Molecular characterization of hepatocystin, the protein that is defective in autosomal dominant polycystic liver disease.
Liver Diseases
PKC? silencing alleviates saturated fatty acid induced ER stress by enhancing SERCA activity.
Liver Failure
Role of cAMP-response element-binding protein phosphorylation in hepatic apoptosis under protein kinase C alpha suppression during sepsis.
Liver Failure
Suppression of protein kinase Calpha triggers apoptosis through down-regulation of Bcl-xL in a rat hepatic epithelial cell line.
Liver Failure, Acute
Sphingosine kinase 1 dependent protein kinase C-? activation plays an important role in acute liver failure in mice.
Liver Neoplasms
Alteration in the expression of protein kinase C isoforms in human hepatocellular carcinoma.
Liver Neoplasms
In vitro and in vivo suppression of growth of rat liver epithelial tumor cells by antisense oligonucleotide against protein kinase C-alpha.
Liver Neoplasms
The altered activity of membrane-bound protein kinase C in human liver cancer.
Liver Neoplasms
The C-terminal 26-residue peptide of serpin A1 stimulates proliferation of breast and liver cancer cells: role of protein kinase C and CD47.
Lordosis
Activation of protein kinase C in the hypothalamic ventromedial nucleus or the midbrain central gray facilitates lordosis.
Lordosis
Activity of protein kinase C is important for 3alpha,5alpha-THP's actions at dopamine type 1-like and/or GABAA receptors in the ventral tegmental area for lordosis of rats.
Lordosis
In the ventral tegmental area, the membrane-mediated actions of progestins for lordosis of hormone-primed hamsters involve phospholipase C and protein kinase C.
Lordosis
Lordosis facilitation by leptin in ovariectomized, estrogen-primed rats requires simultaneous or sequential activation of several protein kinase pathways.
Lordosis
Mapping of neural and signal transduction pathways for lordosis in the search for estrogen actions on the central nervous system.
Lordosis
Phorbol esters and forskolin infused into midbrain central gray facilitate lordosis.
Lung Diseases
Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice.
Lung Diseases
PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel contraction.
Lung Diseases
Thrombin induces collagen gel contraction partially through PAR1 activation and PKC-epsilon.
Lung Injury
Co-inhibition of CD73 and ADORA2B Improves Long-Term Cigarette Smoke Induced Lung Injury.
Lung Injury
Increase in filtration coefficient from actions of melittin on neutrophils in isolated rabbit lungs.
Lung Injury
Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut.
Lung Injury
Protein Kinase C{alpha} and {zeta} Differentially Regulate Death-Inducing Signaling Complex Formation in Cigarette Smoke Extract-Induced Apoptosis.
Lung Injury
Pulmonary endothelial protein kinase C-delta (PKC?) regulates neutrophil migration in acute lung inflammation.
Lung Injury
Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C.
Lung Injury
The effect of acute inflammatory lung injury on the respiratory burst and protein kinase C activity of rat pulmonary alveolar macrophages.
Lung Neoplasms
14-3-3? promotes lung cancer cell invasion by increasing the Snail protein expression through atypical protein kinase C (aPKC)/NF-?B signaling.
Lung Neoplasms
A phase I/II study of LY900003, an antisense inhibitor of protein kinase C-alpha, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer.
Lung Neoplasms
A23187 and protein kinase C activators stimulate phosphatidylinositol metabolism and prostaglandin synthesis in a human lung cancer cell line.
Lung Neoplasms
Activation of protein kinase C by phorbol 12-myristate 13-acetate suppresses the growth of lung cancer cells through KLF6 induction.
Lung Neoplasms
Activation of protein kinase Calpha signaling prevents cytotoxicity and mutagenicity following lead acetate in CL3 human lung cancer cells.
Lung Neoplasms
Additive effects of cherlerythrine chloride combination with erlotinib in human non-small cell lung cancer cells.
Lung Neoplasms
Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance.
Lung Neoplasms
Anticancer drug-mediated induction of multidrug resistance-associated genes and protein kinase C isozymes in the T-lymphoblastoid cell line CCRF-CEM and in blasts from patients with acute lymphoblastic leukemias.
Lung Neoplasms
Antisense expression of protein kinase C alpha improved sensitivity to anticancer drugs in human lung cancer LTEPa-2 cells.
Lung Neoplasms
Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells.
Lung Neoplasms
Associated expression of protein kinase C with resistance to doxorubicin in human lung cancer.
Lung Neoplasms
Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells.
Lung Neoplasms
Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer.
Lung Neoplasms
Atypical protein kinase C phosphorylates Par6 and facilitates transforming growth factor ?-induced epithelial-to-mesenchymal transition.
Lung Neoplasms
Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity.
Lung Neoplasms
Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis.
Lung Neoplasms
Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ciota.
Lung Neoplasms
Bi-directional regulation of Ser-985 phosphorylation of c-met via protein kinase C and protein phosphatase 2A involves c-Met activation and cellular responsiveness to hepatocyte growth factor.
Lung Neoplasms
c-myc gene-induced alterations in protein kinase C expression: a possible mechanism facilitating myc-ras gene complementation.
Lung Neoplasms
Co-dependency of PKC? and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer.
Lung Neoplasms
Cooperation between PKC-alpha and PKC-epsilon in the regulation of JNK activation in human lung cancer cells.
Lung Neoplasms
Cyclooxygenase-2 up-regulates vascular endothelial growth factor via a protein kinase C pathway in non-small cell lung cancer.
Lung Neoplasms
Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation.
Lung Neoplasms
Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes.
Lung Neoplasms
Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer.
Lung Neoplasms
Down-regulation of PKCzeta expression inhibits chemotaxis signal transduction in human lung cancer cells.
Lung Neoplasms
Effects of Atypical Protein Kinase C Inhibitor (DNDA) on Lung Cancer Proliferation and Migration by PKC-?/FAK Ubiquitination Through the Cbl-b Pathway.
Lung Neoplasms
Effects of the new selective protein kinase C inhibitor 4'-N-benzoyl staurosporine on cell cycle distribution and growth inhibition in human small cell lung cancer cells.
Lung Neoplasms
Enhancement of NK cell-mediated lysis of non-small lung cancer cells by nPKC activator, ingenol 3,20 dibenzoate.
Lung Neoplasms
Enzastaurin (LY317615), a Protein Kinase C Beta Selective Inhibitor, Enhances Antiangiogenic Effect of Radiation.
Lung Neoplasms
Epac1 is involved in cell cycle progression in lung cancer through PKC and Cx43 regulation.
Lung Neoplasms
Expression and secretion of parathyroid hormone-related protein by a human cancer cell line.
Lung Neoplasms
FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2.
Lung Neoplasms
Global gene expression profiling reveals a suppressed immune response pathway associated with 3q amplification in squamous carcinoma of the lung.
Lung Neoplasms
High-throughput functional genomic methods to analyze the effects of dietary lipids.
Lung Neoplasms
Inhibition of fibroblast growth factor 2-induced apoptosis involves survivin expression, protein kinase C alpha activation and subcellular translocation of Smac in human small cell lung cancer cells.
Lung Neoplasms
Inhibition of novel protein kinase C-epsilon augments TRAIL-induced cell death in A549 lung cancer cells.
Lung Neoplasms
Inhibition of protein kinase C ?/?II and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells.
Lung Neoplasms
Involvement of TNF-alpha changes in human cancer development, prevention and palliative care.
Lung Neoplasms
l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters.
Lung Neoplasms
LY900003 (Affinitac), an antisense inhibitor of protein kinase C-alpha, in non-small-cell lung cancer.
Lung Neoplasms
Molecular and pharmacological properties of inwardly rectifying K+ channels of human lung cancer cells.
Lung Neoplasms
Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon.
Lung Neoplasms
Ophiopogon Saponin C1 Inhibits Lung Tumors by Stabilizing Endothelium Permeability via Inhibition of PKC?.
Lung Neoplasms
Phase I dose escalation study of the PKC? inhibitor aurothiomalate for advanced non-small-cell lung cancer, ovarian cancer, and pancreatic cancer.
Lung Neoplasms
Phase I study of PKC412 (N-benzoyl-staurosporine), a novel oral protein kinase C inhibitor, combined with gemcitabine and cisplatin in patients with non-small-cell lung cancer.
Lung Neoplasms
Phase II study of PKC-alpha antisense oligonucleotide aprinocarsen in combination with gemcitabine and carboplatin in patients with advanced non-small cell lung cancer.
Lung Neoplasms
Phase III study of gemcitabine and cisplatin with or without aprinocarsen, a protein kinase C-alpha antisense oligonucleotide, in patients with advanced-stage non-small-cell lung cancer.
Lung Neoplasms
PKC? regulates integrin ?V?3 expression and transformed growth of K-ras dependent lung cancer cells.
Lung Neoplasms
PKC? regulates Rho GTPases and actin cytoskeleton reorganization in non-small cell lung cancer cells.
Lung Neoplasms
PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells.
Lung Neoplasms
PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathway.
Lung Neoplasms
Preparation and in-vitro Evaluation of an Antisense-containing Cationic Liposome against Non-small Cell Lung Cancer: a Comparative Preparation Study.
Lung Neoplasms
Protein kinase C delta-mediated cytoskeleton remodeling is involved in aloe-emodin-induced photokilling of human lung cancer cells.
Lung Neoplasms
Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner.
Lung Neoplasms
Protein kinase C iota: human oncogene, prognostic marker and therapeutic target.
Lung Neoplasms
Protein kinase C is not involved in the homologous desensitization of bombesin responses in small cell lung cancer cells.
Lung Neoplasms
Protein Kinase C Isozymes Associated With Relapse Free Survival in Non-Small Cell Lung Cancer Patients.
Lung Neoplasms
Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway.
Lung Neoplasms
Protein kinase Cgamma autoimmunity in paraneoplastic cerebellar degeneration and non-small-cell lung cancer.
Lung Neoplasms
Protein kinase Czeta abrogates the proapoptotic function of Bax through phosphorylation.
Lung Neoplasms
Protein Kinase C{iota} Promotes Nicotine-induced Migration and Invasion of Cancer Cells via Phosphorylation of {micro}- and m-Calpains.
Lung Neoplasms
Protein kinase D in small cell lung cancer cells: rapid activation through protein kinase C.
Lung Neoplasms
Role of protein kinase C in expression of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells.
Lung Neoplasms
Roles of partitioning-defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells.
Lung Neoplasms
S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells.
Lung Neoplasms
Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells.
Lung Neoplasms
Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp.
Lung Neoplasms
Staurosporine increases toxicity of gemcitabine in non-small cell lung cancer cells: role of protein kinase C, deoxycytidine kinase and ribonucleotide reductase.
Lung Neoplasms
Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC??/ERK1/2 pathway: An in vitro investigation.
Lung Neoplasms
Suppression of cancer cell migration and invasion by protein phosphatase 2A through dephosphorylation of mu- and m-calpains.
Lung Neoplasms
Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase.
Lung Neoplasms
The oncogenic role of PKCiota gene amplification and overexpression in Chinese non-small cell lung cancer.
Lung Neoplasms
The protein kinase C (PKC) inhibitors combined with chemotherapy in the treatment of advanced non-small cell lung cancer: meta-analysis of randomized controlled trials.
Lung Neoplasms
The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer.
Lung Neoplasms
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation.
Lung Neoplasms
Transactivation of hsp70-1/2 in geldanamycin-treated human non-small cell lung cancer H460 cells: involvement of intracellular calcium and protein kinase C.
Lung Neoplasms
[A study on the relationship between the expression of protein kinase C ?II and apoptosis in patients with non-small cell lung cancer.]
Lung Neoplasms
[Effects of a protein kinase C inhibitor combined with cisplatin on non-small cell lung cancer]
Lung Neoplasms
[nm23-H1 gene inhibits lung cancer cell invasion through down-regulation of PKC signal pathway]
Lung Neoplasms
[Study on protein kinase C translocation before and after transfection of nm23-H1 gene in human lung cancer cells using Laser scanning confocal microscope.]
Lung Neoplasms
[The clinical signifcance of expression of ERCC1 and PkCalpha in non-small cell lung cancer]
Lung Neoplasms
[The variation of intracellular distribution and translocation of the protein kinase C alpha among human lung cancer cell line with different metastasis potential.]
Lupus Erythematosus, Systemic
A defect in the protein kinase C system in T cells from patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Abnormal cell-specific expressions of certain protein kinase C isoenzymes in peripheral mononuclear cells of patients with systemic lupus erythematosus: effect of corticosteroid application.
Lupus Erythematosus, Systemic
Adenosine inhibits the release of arachidonic acid in activated human peripheral mononuclear cells. A proposed model for physiologic and pathologic regulation in systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Different effects of Bortezomib on the expressions of various PKC isoenzymes in T cells of patients with systemic lupus erythematosus and in Jurkat cells.
Lupus Erythematosus, Systemic
Impaired respiratory burst contributes to infections in PKC?-deficient patients.
Lupus Erythematosus, Systemic
Season Dependent Changes in the Expression of Protein Kinase C Isoenzymes in a Female Patient with Systemic Lupus Erythematosus.
Lupus Erythematosus, Systemic
Successful use of ofatumumab in two cases of early-onset juvenile SLE with thrombocytopenia caused by a mutation in protein kinase C ?.
Lupus Erythematosus, Systemic
The in vitro treatment with vitamin D3 is ineffective on the expression of PKC isoenzymes, but decreases further the impaired production of IL-2 in the T lymphocytes of SLE patients.
Lymphadenitis
The protein kinase C system in focal adenitis of the lacrimal gland in the non-obese diabetic mouse model for Sjögren's syndrome.
Lymphatic Metastasis
Localization of PKC? in Cell Membranes as a Predictor for Breast Cancer Response to Treatment.
Lymphatic Metastasis
Over-expression of protein kinase C?isoforms (?, ?, ? and ?) in squamous cervical cancer.
Lymphatic Metastasis
Pak-1 expression increases with progression of colorectal carcinomas to metastasis.
Lymphatic Metastasis
Protein interacting with C alpha kinase 1 (PICK1) is involved in promoting tumor growth and correlates with poor prognosis of human breast cancer.
Lymphocytosis
Molecular mechanisms of lymphocyte extravasation. III. The loss of lymphocyte extravasation potential induced by pertussis toxin is not mediated via the activation of protein kinase C.
Lymphoma
A critical role for the protein kinase PKK in the maintenance of recirculating mature B cells and the development of B1 cells.
Lymphoma
A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma.
Lymphoma
Altered regulation of cyclic AMP-dependent protein kinase in a mouse lymphoma cell line.
Lymphoma
Anti-IgM-mediated growth inhibition of a human B lymphoma cell line is independent of phosphatidylinositol turnover and protein kinase C activation and involves tyrosine phosphorylation.
Lymphoma
Antioxidant ?-tocopherol checks lymphoma promotion via regulation of expression of protein kinase C-? and c-Myc genes and glycolytic metabolism.
Lymphoma
Bcl-2/Bax Expression Levels Tend to Influence AMPAergic Trafficking Mechanisms During Hibernation in Mesocricetus auratus.
Lymphoma
Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: Relationship between its expression and prognosis.
Lymphoma
Conventional protein kinase C isoforms are not essential for cellular proliferation of a T cell lymphoma line.
Lymphoma
Differential expression of protein kinase C isoenzymes related to high nitric oxide synthase activity in a T lymphoma cell line.
Lymphoma
Downregulation of T cell growth factor production by ornithine decarboxylase and its product putrescine: D,L-alpha-difluoromethylornithine suppresses general protein synthesis but augments simultaneously the production of interleukin-2.
Lymphoma
Effects of enzastaurin, alone or in combination, on signaling pathway controlling growth and survival of B-cell lymphoma cell lines.
Lymphoma
Effects of mezerein and diglycerides on the PRL stimulation of cell replication in Nb2 node lymphoma cells.
Lymphoma
Expression of classical protein kinase C subspecies in non-neoplastic lymphocytes and non-Hodgkin's lymphomas: an immunohistochemical study.
Lymphoma
In vivo administration of bryostatin 1, a protein kinase C activator, decreases murine resistance to Salmonella typhimurium.
Lymphoma
In vivo and in vitro modulatory effect of human immunodeficiency virus type-1 (HIV-1) Tat protein on protein kinase C activity.
Lymphoma
Increased degradation of protein kinase C without diminution of mRNA level after treatment of WEHI-231 B lymphoma cells with phorbol esters.
Lymphoma
Invariant chain (CD74) gene regulation: enhanced expression associated with activation of protein kinase C delta in a murine B lymphoma cell line.
Lymphoma
Lymphoma models for B cell activation and tolerance. VIII. Cross-desensitization by sIgM and sIgD and its effects on growth regulation by anti-isotype antibodies.
Lymphoma
Lymphoma protein kinase C is associated with the transmembrane glycoprotein, GP85, and may function in GP85-ankyrin binding.
Lymphoma
Membrane IgM cross-linking is not coupled to protein kinase C translocation in WEHI-231 B lymphoma cells.
Lymphoma
Modulation of CD40L antigen expression in Jurkat cells: involvement of protein kinase C activity.
Lymphoma
Modulation of protein kinase C and Ca2+ lipid-independent protein kinase in lymphoma induced by Moloney murine leukemia virus in BALB/c mice.
Lymphoma
Molecular basis of targeted chemotherapy: novel concepts with special reference to the treatment of Hodgkin's disease.
Lymphoma
Multiple effects of phorbol esters on hormone-sensitive adenylate cyclase activity in S49 lymphoma cells.
Lymphoma
Multiple non-specific effects of sphingosine on adenylate cyclase and cyclic AMP accumulation in S49 lymphoma cells preclude its use as a specific inhibitor of protein kinase C.
Lymphoma
Nuclear translocation of prolactin: collaboration of tyrosine kinase and protein kinase C activation in rat Nb2 node lymphoma cells.
Lymphoma
PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia.
Lymphoma
Prolactin stimulation of ornithine decarboxylase and mitogenesis in Nb2 node lymphoma cells: the role of protein kinase C and calcium mobilization.
Lymphoma
Prolactin-stimulated mitogenesis of cultured astrocytes is mediated by a protein kinase C-dependent mechanism.
Lymphoma
Protein kinase C activation blocks anti-IgM-mediated signaling BAL17 B lymphoma cells.
Lymphoma
Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase.
Lymphoma
Protein kinase C-delta mRNA is down-regulated transcriptionally and post-transcriptionally by 12-O-tetradecanoylphorbol-13-acetate.
Lymphoma
Regulation of protein kinase C isoform proteins in phorbol ester-stimulated Jurkat T lymphoma cells.
Lymphoma
Role of phosphoinositide-derived second messengers in mediating anti-IgM-induced growth arrest of WEHI-231 B lymphoma cells.
Lymphoma
Selective role of PKCbeta enzymatic function in regulating cell survival mediated by B cell antigen receptor cross-linking.
Lymphoma
Sodium selenite-induced apoptosis in murine B-lymphoma cells is associated with inhibition of protein kinase C-delta, nuclear factor kappaB, and inhibitor of apoptosis protein.
Lymphoma
Stabilization of invariant chain mRNA by 12-O-tetradecanoylphorbol-13-acetate is blocked by IFN-gamma in a murine B lymphoma cell line.
Lymphoma
Studies on the possible role of protein kinase C in the prolactin regulation of cell replication in Nb2 node lymphoma cells.
Lymphoma
Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells.
Lymphoma
The phosphatidylinositol 3-kinases (PI3K) inhibitor GS-1101 synergistically potentiates histone deacetylase inhibitor-induced proliferation inhibition and apoptosis through the inactivation of PI3K and extracellular signal-regulated kinase pathways.
Lymphoma
The phosphoprotein phosphatase calcineurin controls calcium-dependent apoptosis in B cell lines.
Lymphoma
Transient down-regulation of PKC-zeta RNA following crosslinking of membrane IgM on WEHI-231 B lymphoma cells.
Lymphoma, B-Cell
Altered apoptosis-related signaling after cardioplegic arrest in patients with uncontrolled type 2 diabetes mellitus.
Lymphoma, B-Cell
Association of elevated levels of protein kinase C-zeta mRNA and protein with murine B-lymphocytic neoplasia.
Lymphoma, B-Cell
Bcl-2/Bax Expression Levels Tend to Influence AMPAergic Trafficking Mechanisms During Hibernation in Mesocricetus auratus.
Lymphoma, B-Cell
Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: Relationship between its expression and prognosis.
Lymphoma, B-Cell
Cross-talk between protein kinase C-alpha (PKC-alpha) and -delta (PKC-delta): PKC-alpha elevates the PKC-delta protein level, altering its mRNA transcription and degradation.
Lymphoma, B-Cell
Effects of enzastaurin, alone or in combination, on signaling pathway controlling growth and survival of B-cell lymphoma cell lines.
Lymphoma, B-Cell
ERK and p38 upregulation versus Bcl-6 downregulation in rat kidney epithelial cells exposed to prolonged hypoxia.
Lymphoma, B-Cell
Functional Doxorubicin-Loaded Omega-3 Unsaturated Fatty Acids Nanoparticles in Reversing Hepatocellular Carcinoma Multidrug Resistance.
Lymphoma, B-Cell
Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects.
Lymphoma, B-Cell
Phase II study of bryostatin 1 and vincristine for aggressive non-Hodgkin lymphoma relapsing after an autologous stem cell transplant.
Lymphoma, B-Cell
Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Prognostic impact of protein kinase C beta II expression in R-CHOP-treated diffuse large B-cell lymphoma patients.
Lymphoma, B-Cell
Protein kinase C ? inhibits autophagy and sensitizes cervical cancer Hela cells to cisplatin.
Lymphoma, B-Cell
Protein Kinase C Inhibitor Sotrastaurin Selectively Inhibits the Growth of CD79 Mutant Diffuse Large B-Cell Lymphomas.
Lymphoma, B-Cell
Randomized, Double-Blind, Phase III Trial of Enzastaurin Versus Placebo in Patients Achieving Remission After First-Line Therapy for High-Risk Diffuse Large B-Cell Lymphoma.
Lymphoma, B-Cell
Spontaneous high-titered IgG antibody responses against BCL-2 in patients with aggressive lymphomas.
Lymphoma, B-Cell
The expression of microRNAs and exposure to environmental contaminants related to human health: a review.
Lymphoma, B-Cell, Marginal Zone
Immunohistochemical staining of protein kinase C isozymes (betaII and delta) is helpful to distinguish reactive follicles from follicular colonization of MALT lymphoma.
Lymphoma, Follicular
PKC zeta mTOR pathway: a new target for rituximab therapy in follicular lymphoma.
Lymphoma, Large B-Cell, Diffuse
Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: Relationship between its expression and prognosis.
Lymphoma, Large B-Cell, Diffuse
Phase II study of bryostatin 1 and vincristine for aggressive non-Hodgkin lymphoma relapsing after an autologous stem cell transplant.
Lymphoma, Large B-Cell, Diffuse
Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Phorbol esters, but not the hormonal form of vitamin D, induce changes in protein kinase C during differentiation of human histiocytic lymphoma cell line (U-937).
Lymphoma, Large B-Cell, Diffuse
Prognostic impact of protein kinase C beta II expression in R-CHOP-treated diffuse large B-cell lymphoma patients.
Lymphoma, Large B-Cell, Diffuse
Randomized, Double-Blind, Phase III Trial of Enzastaurin Versus Placebo in Patients Achieving Remission After First-Line Therapy for High-Risk Diffuse Large B-Cell Lymphoma.
Lymphoma, Mantle-Cell
A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma.
Lymphoma, Non-Hodgkin
Enhanced expression of CD20 in human tumor B cells is controlled through ERK-dependent mechanisms.
Lymphoma, Non-Hodgkin
Phase II study of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C alpha, in patients with previously treated low-grade non-Hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
Synthetic peptides derived from the nonmuscle myosin light chains are highly specific substrates for protein kinase C.
Lymphoma, T-Cell
Conventional protein kinase C isoforms are not essential for cellular proliferation of a T cell lymphoma line.
Lymphoma, T-Cell
Development and characterization of a protein kinase C beta-isozyme-deficient T-cell line.
Lymphoma, T-Cell
PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia.
Lymphoma, T-Cell
Regulation of CD3 expression in a protein kinase C isozyme-deficient T-cell line.
Lymphoma, T-Cell
Regulation of non-classical protein kinase C isoenzymes in a human T cell line.
Lymphoma, T-Cell, Cutaneous
Down-regulation of Langerhans cell protein kinase C-beta isoenzyme expression in inflammatory and hyperplastic dermatoses.
Lymphoma, T-Cell, Cutaneous
The selective protein kinase C beta inhibitor enzastaurin induces apoptosis in cutaneous T-cell lymphoma cell lines through the AKT pathway.
Lymphoma, T-Cell, Peripheral
Bcl-10 protein highly correlates with the expression of phosphorylated p65 NF-kappaB in peripheral T-cell lymphomas and is associated with clinical outcome.
Lymphoproliferative Disorders
A novel treatment approach for low grade lymphoproliferative disorders using PKC412 (CGP41251), an inhibitor of protein kinase C.
Lymphoproliferative Disorders
Cyclosporin A Up-Regulates and Activates Protein Kinase C-zeta in EBV-Infected and EBV-Transformed Human B-Cells.
Macular Edema
Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema.
Macular Edema
Effects of protein kinase C inhibition and activation on proliferation and apoptosis of bovine retinal pericytes.
Macular Edema
IGFBP-3 reduces eNOS and PKCzeta phosphorylation, leading to lowered VEGF levels.
Macular Edema
Inhibition of protein kinase C delta attenuates blood-retinal barrier breakdown in diabetic retinopathy.
Macular Edema
Mechanisms for monitoring changes in retinal status following therapeutic intervention in diabetic retinopathy.
Macular Edema
Protein Kinase C Inhibitors in the Treatment of Diabetic Retinopathy. Review.
Magnesium Deficiency
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Malaria, Cerebral
Activation of nuclear transcription factor-kappa B is associated with the induction of inhibitory kappa B kinase-beta and involves differential activation of protein kinase C and protein tyrosine kinases during fatal murine cerebral malaria.
Malaria, Cerebral
Protein kinase C ? deficiency increases resistance of C57BL/6J mice to Plasmodium berghei infection-induced cerebral malaria.
Mania
A preliminary investigation of a protein kinase C inhibitor in the treatment of acute mania.
Mania
A review of the preclinical and clinical evidence for protein kinase C as a target for drug development for bipolar disorder.
Mania
Altered platelet protein kinase C activity in bipolar affective disorder, manic episode.
Mania
Effects of acute and chronic quercetin administration on methylphenidate-induced hyperlocomotion and oxidative stress.
Mania
Effects of tamoxifen and glutamate and glutamine levels in brain regions in repeated sleep deprivation-induced mania model in mice.
Mania
Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study.
Mania
Efficacy of endoxifen, a protein kinase C inhibitor for acute and mixed mania: Some concerns worth considering.
Mania
Endoxifen: A new, protein kinase C inhibitor to treat acute and mixed mania associated with bipolar I disorder.
Mania
Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of Mania.
Mania
Intracellular phosphatidylinositol pathway abnormalities in bipolar disorder patients.
Mania
Lithium and Tamoxifen Modulate Behavior and Protein Kinase C Activity in the Animal Model of Mania Induced by Ouabain.
Mania
Lithium and tamoxifen modulate cellular plasticity cascades in animal model of mania.
Mania
Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen.
Mania
Protein kinase C inhibition rescues manic-like behaviors and hippocampal cell proliferation deficits in the sleep deprivation model of mania.
Mania
Protein kinase C inhibitors: rationale for use and potential in the treatment of bipolar disorder.
Mania
Protein kinase C isoforms as a target for manic-like behaviors and oxidative stress in a dopaminergic animal model of mania.
Mania
Protein kinase C regulates mood-related behaviors and adult hippocampal cell proliferation in rats.
Mania
Severe recurrent hypothermia in an elderly patient with refractory mania associated with atypical antipsychotic, valproic acid and oxcarbazepine therapy.
Mania
Tamoxifen: A Protein Kinase C Inhibitor to Treat Mania: A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials.
Mastocytoma
Critical role of protein kinase C betaII in activation of mast cells by monomeric IgE.
Mastocytoma
Involvement of protein kinase C in thrombin-induced translocation of Gi2 alpha from the membrane to the cytosol in mouse mastocytoma P-815 cells.
Mastocytoma
Synergistic effects of 12-O-tetradecanoylphorbol-13-acetate and dexamethasone on de novo synthesis of histidine decarboxylase in mouse mastocytoma P-815 cells.
Measles
Early signal transduction in measles virus-infected lymphocytes is unaltered, but second messengers activate virus replication.
Measles
Effect of persistent measles virus infection on protein kinase C activity and c-fos protooncogene expression in neuroblastoma cells.
Measles
Immunological unresponsiveness and apoptotic cell death of T cells in measles virus infection.
Measles
Measles virus induces apoptotic cell death in lymphocytes activated with phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore.
Measles
Phosphorylation of canine distemper virus P protein by protein kinase C-zeta and casein kinase II.
Melanoma
12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids.
Melanoma
A selective protein kinase C inhibitor (CGP 41251) positively and negatively modulates melanoma cell MSH receptors.
Melanoma
A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion.
Melanoma
Activation of protein kinase C-alpha isoform in murine melanoma cells with high metastatic potential.
Melanoma
Activation of the integrin effector kinase focal adhesion kinase in cancer cells is regulated by crosstalk between protein kinase Calpha and the PDZ adapter protein mda-9/Syntenin.
Melanoma
Alpha-melanocyte-stimulating hormone stimulates protein kinase C activity in murine B16 melanoma.
Melanoma
Angiopoietin-like 4 promotes melanoma cell invasion and survival through aldolase A.
Melanoma
Antimetastatic Action of Pentoxifylline, a Methyl Xanthine Derivative, Through its Effect on PKC Mediated Integrin Transport in B16F10 Melanoma Cells.
Melanoma
AP-1 and C/EBP transcription factors contribute to mda-7 gene promoter activity during human melanoma differentiation.
Melanoma
Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-alpha and translocating PKC-delta.
Melanoma
c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis.
Melanoma
CD36 Ectodomain Phosphorylation Blocks Thrombospondin-1 Binding: Structure-Function Relationships and Regulation by Protein Kinase C.
Melanoma
Cell differentiation and cell-cycle alterations by tyrosine kinase inhibitors in human melanoma cells.
Melanoma
Characterization of density-dependent regulation of the tyrosinase gene promoter: role of protein kinase C.
Melanoma
Characterization of retinoic acid-induced AP-1 activity in B16 mouse melanoma cells.
Melanoma
Circulating Tumor DNA Reflects Uveal Melanoma Responses to Protein Kinase C Inhibition.
Melanoma
Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility.
Melanoma
Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH.
Melanoma
Combination therapy of PKC? and COX-2 inhibitors synergistically suppress melanoma metastasis.
Melanoma
Cytotoxic effects of sphingolipids as single or multi-modality agents on human melanoma and soft tissue sarcoma in vitro.
Melanoma
Dehydroepiandrosterone inhibits B16 mouse melanoma cell growth by induction of differentiation.
Melanoma
Detecting PKC phosphorylation as part of the Wnt/calcium pathway in cutaneous melanoma.
Melanoma
Differential expression of protein kinase C and cAMP-dependent protein kinase in normal human melanocytes and malignant melanomas.
Melanoma
Differential roles of protein kinase C and pertussis toxin-sensitive G-binding proteins in modulation of melanoma cell proliferation and motility by thrombospondin 1.
Melanoma
DOG1 Utility in diagnosing gastrointestinal stromal tumors on fine-needle aspiration.
Melanoma
Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma.
Melanoma
Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion.
Melanoma
Effect of PKC412, an inhibitor of protein kinase C, on spontaneous metastatic model mice.
Melanoma
Effect of protein kinase C inhibitors on invasiveness of human melanoma clones expressing different levels of protein kinase C isoenzymes.
Melanoma
Effects of protein kinase inhibitors on radiation-induced WAF1 accumulation in human cultured melanoma cells.
Melanoma
Expression and regulation of phospholipase D isoenzymes in human melanoma cells and primary melanocytes.
Melanoma
Expression of a metastatic phenotype in IFNs-primed/TNFalpha-activated B16 murine melanoma cells: role of JAK1/PKCdelta signal transduction factors.
Melanoma
Gastrointestinal stromal tumor markers in cutaneous melanomas: relationship to prognostic factors and outcome.
Melanoma
Genomic Profiling of Metastatic Uveal Melanoma and Clinical Results of a Phase I Study of the Protein Kinase C Inhibitor AEB071.
Melanoma
Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties.
Melanoma
Growth inhibition of human melanoma-derived cells by 12-O-tetradecanoyl phorbol 13-acetate.
Melanoma
Growth of melanocytic cells is associated with down-regulation of protein kinase C alpha, delta, and epsilon isoforms. Possible role of diacylglycerol.
Melanoma
Higher levels of melanin and inhibition of cdk2 activity in primary human melanoma cells WM115 overexpressing nPKCdelta.
Melanoma
Human melanoma metastasis is inhibited following ex vivo treatment with an antisense oligonucleotide to protein kinase C-alpha.
Melanoma
IFN?-mediated inhibition of cell proliferation through increased PKC?-induced overexpression of EC-SOD.
Melanoma
In vivo administration of bryostatin 1, a protein kinase C activator, decreases murine resistance to Salmonella typhimurium.
Melanoma
Increased expression of protein kinase C alpha plays a key role in retinoic acid-induced melanoma differentiation.
Melanoma
Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway.
Melanoma
Inhibition of experimental metastasis and cell adhesion of B16F1 melanoma cells by inhibitors of protein kinase C.
Melanoma
Inhibition of PKCalpha decreases the gelatinase activity and the angiogenic and metastatic ability of the highly metastatic B16 murine melanoma cells.
Melanoma
Interactions between retinoic acid and protein kinase C in induction of melanoma differentiation.
Melanoma
Investigation of signal transduction pathways involved in melanoma cell spreading.
Melanoma
Lack of protein kinase C (PKC)-beta and low PKC-alpha, -delta, -epsilon, and -zeta isozyme levels in proliferating human melanoma cells.
Melanoma
Loss of expression of protein kinase C beta is a common phenomenon in human malignant melanoma: a result of transformation or differentiation?
Melanoma
Low molecular weight heparin inhibits melanoma cell adhesion and migration through a PKCa/JNK signaling pathway inducing actin cytoskeleton changes.
Melanoma
Methylselenol generated from selenomethionine by methioninase downregulates integrin expression and induces caspase-mediated apoptosis of B16F10 melanoma cells.
Melanoma
Modulation by palmitoyl-carnitine of calcium activated, phospholipid-dependent protein kinase activity and inhibition of melanoma cell growth.
Melanoma
Modulation of human melanoma cell metastasis and adhesion may involve integrin phosphorylation mediated through protein kinase C.
Melanoma
Negative regulation of endogenous protein kinase Calpha on the dynamic change of carbachol-induced intracellular calcium response in different melanoma cells.
Melanoma
Oncogenic PKC-? activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-? and PKC-? specific inhibitors.
Melanoma
Osteonectin/SPARC induction by ectopic beta(3) integrin in human radial growth phase primary melanoma cells.
Melanoma
Overexpression of novel protein kinase C delta in BL6 murine melanoma cells inhibits the proliferative capacity in vitro but enhances the metastatic potential in vivo.
Melanoma
Overexpression of nPKCdelta in BL6 murine melanoma cells enhances TGFbeta1 release into the plasma of metastasized animals.
Melanoma
Pharmacogenomics of metabotropic glutamate receptor subtype 1 and in vivo malignant melanoma formation.
Melanoma
Phorbol ester impairs melanotropin receptor function and stimulates growth of cultured M2R melanoma cells.
Melanoma
Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2.
Melanoma
Photo-induced inactivation of protein kinase calpha by dequalinium inhibits motility of murine melanoma cells.
Melanoma
PKC? phosphorylation regulates the mitochondrial translocation of ATF2 in ischemia-induced neurodegeneration.
Melanoma
PKCdelta inhibits PKCalpha-mediated activation of phospholipase D1 in a manner independent of its protein kinase activity.
Melanoma
Proliferation of human melanoma cells is under tight control of protein kinase C alpha.
Melanoma
Protein kinase C alpha associates with phospholipase D1 and enhances basal phospholipase D activity in a protein phosphorylation-independent manner in human melanoma cells.
Melanoma
Protein kinase C beta expression in melanoma cells and melanocytes: differential expression correlates with biological responses to 12-O-tetradecanoylphorbol 13-acetate.
Melanoma
Protein Kinase C Inhibitor AEB071 Targets Ocular Melanoma Harboring GNAQ Mutations via Effects on the PKC/Erk1/2 and PKC/NF-?B Pathways.
Melanoma
Protein kinase C inhibitor anchored BRD4 PROTAC PEGylated nanoliposomes for the treatment of vemurafenib-resistant melanoma.
Melanoma
Protein kinase C inhibitor Gö6976 but not Gö6983 induces the reversion of E- to N-cadherin switch and metastatic phenotype in melanoma: identification of the role of protein kinase D1.
Melanoma
Protein Kinase C Inhibitors Sensitize GNAQ Mutant Uveal Melanoma Cells to Ionizing Radiation.
Melanoma
Protein kinase C isoforms in normal and transformed cells of the melanocytic lineage.
Melanoma
Protein kinase C-betaII represses hepatocyte growth factor-induced invasion by preventing the association of adapter protein Gab1 and phosphatidylinositol 3-kinase in melanoma cells.
Melanoma
Protein kinase Calpha plays a critical role in mannosylerythritol lipid-induced differentiation of melanoma B16 cells.
Melanoma
RaSH, a rapid subtraction hybridization approach for identifying and cloning differentially expressed genes.
Melanoma
Regulation of docetaxel-induced apoptosis of human melanoma cells by different isoforms of protein kinase C.
Melanoma
Regulation of protein kinase C gene expression by retinoic acid in B16 mouse melanoma cells.
Melanoma
Regulation of retinoic acid receptor alpha by protein kinase C in B16 mouse melanoma cells.
Melanoma
Regulatory factors that determine growth and phenotype of normal human melanocytes.
Melanoma
Retinoic acid specifically increases nuclear PKC alpha and stimulates AP-1 transcriptional activity in B16 mouse melanoma cells.
Melanoma
RNAi-mediated knockdown of protein kinase C-alpha inhibits cell migration in MM-RU human metastatic melanoma cell line.
Melanoma
Selective increase of the alpha subspecies of protein kinase C and inhibition of melanogenesis induced by retinoic acid in melanoma cells.
Melanoma
Selective PKC? inhibitor B106 elicits uveal melanoma growth inhibitory effects independent of activated PKC isoforms.
Melanoma
Src, PKCalpha, and PKCdelta are required for alphavbeta3 integrin-mediated metastatic melanoma invasion.
Melanoma
Stimulation of C32 and G361 melanoma cells using oleoyl acetyl glycerol and its effect on sulphur mustard cytotoxicity.
Melanoma
Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCepsilon.
Melanoma
Structural alteration in the MYB protooncogene and deletion within the gene encoding alpha-type protein kinase C in human melanoma cell lines.
Melanoma
Survival mechanisms induced by 12-O-tetradecanoylphorbol-13-acetate in normal human melanocytes include inhibition of apoptosis and increased Bcl-2 expression.
Melanoma
Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways.
Melanoma
The beta isoform of protein kinase C stimulates human melanogenesis by activating tyrosinase in pigment cells.
Melanoma
The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells.
Melanoma
The differential expression of protein kinase C genes in normal human neonatal melanocytes and metastatic melanomas.
Melanoma
The high affinity alphaIIb beta3 integrin is involved in invasion of human melanoma cells.
Melanoma
The Phosphoinositide 3-Kinase? Selective Inhibitor, BYL719, Enhances the Effect of the Protein Kinase C Inhibitor, AEB071, in GNAQ/GNA11 Mutant Uveal Melanoma Cells.
Melanoma
The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma.
Melanoma
The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2.
Melanoma
The relationship between susceptibility to retinoic acid treatment and protein kinase C alpha expression in murine melanoma cell lines.
Melanoma
Timp1 Promotes Cell Survival by Activating the PDK1 Signaling Pathway in Melanoma.
Melanoma
TPA inhibits melanoma growth by inactivation of STAT3 through PKC-activated tyrosine phosphatase(s).
Melanoma
Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis.
Melanoma
Ultraviolet radiation-induced melanogenesis in human melanocytes. Effects of modulating protein kinase C.
Melanoma
Variable expression of protein kinase C epsilon in human melanoma cells regulates sensitivity to TRAIL-induced apoptosis.
Melanoma
VEGFR1 and PKC? signaling control melanoma vasculogenic mimicry in a VEGFR2 kinase-independent manner.
Melanoma
WNT5A-Induced Activation of the Protein Kinase C Substrate MARCKS Is Required for Melanoma Cell Invasion.
Melanoma
[Effect of protein kinase C on human melanoma A375-S2 cell death induced by evodiamine]
Melanoma
[Inhibition of experimental metastasis and cell adhesion of B16 murine melanoma cells by protein kinase C inhibitor CJ9111]
Melanoma, Amelanotic
12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids.
Melanoma, Experimental
A short peptide is a protein kinase C (PKC) alpha-specific substrate.
Melanoma, Experimental
Activation of protein kinase C-alpha isoform in murine melanoma cells with high metastatic potential.
Melanoma, Experimental
Alpha-melanocyte-stimulating hormone stimulates protein kinase C activity in murine B16 melanoma.
Melanoma, Experimental
B16 mouse melanoma cells selected for resistance to cyclic AMP-mediated growth inhibition are cross-resistant to retinoic acid-induced growth inhibition.
Melanoma, Experimental
Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.
Melanoma, Experimental
Cloning and characterization of the murine PKC alpha promoter: identification of a retinoic acid response element.
Melanoma, Experimental
Effect of PKC412, a selective inhibitor of protein kinase C, on lung metastasis in mice injected with B16 melanoma cells.
Melanoma, Experimental
Enhanced expression of protein kinase C subspecies in melanogenic compartments in B16 melanoma cells by UVB or MSH.
Melanoma, Experimental
Induction of protein kinase C in mouse melanoma cells by retinoic acid.
Melanoma, Experimental
Inhibition of B16 melanoma cell proliferation and alterations in p21 ras expression induced by interceptors of signal transduction pathways.
Melanoma, Experimental
Phloridzin-induced melanogenesis is mediated by the cAMP signaling pathway.
Melanoma, Experimental
Protein kinase Calpha plays a critical role in mannosylerythritol lipid-induced differentiation of melanoma B16 cells.
Melanoma, Experimental
Saikosaponin b2 induces differentiation without growth inhibition in cultured B16 melanoma cells.
Melanoma, Experimental
Saikosaponin b2-induced apoptosis of cultured B16 melanoma cell line through down-regulation of PKC activity.
Melanoma, Experimental
Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
Melanoma, Experimental
Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
Melanoma, Experimental
Treatment of patients with metastatic melanoma with bryostatin-1--a phase II study.
Melanoma, Experimental
Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis.
Melanoma, Experimental
Vitamin A (retinoids) regulation of mouse melanoma growth and differentiation.
Memory Disorders
Acetyl-L-Carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C.
Memory Disorders
Chronic bryostatin-1 rescues autistic and cognitive phenotypes in the fragile X mice.
Memory Disorders
Neuroprotective Effects of Adenosine A1 Receptor Signaling on Cognitive Impairment Induced by Chronic Intermittent Hypoxia in Mice.
Memory Disorders
Small-molecule drug screening identifies drug Ro 31-8220 that reduces toxic phosphorylated tau in Drosophila melanogaster.
Meningioma
The regulatory effects of protein kinase C on the proliferation of cultured human low-passage meningioma cells.
Meningitis
Escherichia coli K-1 interaction with human brain micro-vascular endothelial cells triggers phospholipase C-gamma1 activation downstream of phosphatidylinositol 3-kinase.
Mesenteric Ischemia
Protein kinase epsilon dampens the secretory response of model intestinal epithelia during ischemia.
Mesothelioma
Role of protein kinase C ? and vascular endothelial growth factor receptor in malignant pleural mesothelioma: Therapeutic implications and the usefulness of Caenorhabditis elegans model organism.
Mesothelioma, Malignant
Role of protein kinase C ? and vascular endothelial growth factor receptor in malignant pleural mesothelioma: Therapeutic implications and the usefulness of Caenorhabditis elegans model organism.
Metabolic Diseases
Divergent effects of phorbol esters and insulin on insulin-like growth factor binding protein-1 (IGFBP-1) production and mRNA in rat H4IIE hepatoma cells.
Metabolic Diseases
The osteogenic or adipogenic lineage commitment of human mesenchymal stem cells is determined by protein kinase C delta.
Metabolic Syndrome
Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus.
Metabolic Syndrome
Renoprotective and blood pressure-lowering effect of dietary soy protein via protein kinase C betaII inhibition in a rat model of metabolic syndrome.
Metabolism, Inborn Errors
A model for PKC involvement in the pathogenesis of inborn errors of metabolism.
Metabolism, Inborn Errors
Inhibition of protein kinase C activity in mucolipidosis type-4: a model for a new pathogenetic mechanism in inborn errors of metabolism.
Metabolism, Inborn Errors
Possible role for protein kinase C in the pathogenesis of inborn errors of metabolism.
Microcephaly
Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish.
Migraine Disorders
Protein Kinase C ? Contributes to Central Sensitization in a Rat Model of Chronic Migraine.
Migraine Disorders
Protein kinase C-dependent activation of human K(2P) 18.1 K(+) channels.
Migraine Disorders
Protein kinase C? as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice.
Migraine Disorders
Valproate Plays a Protective Role against Migraine by Inhibiting Protein Kinase C Signalling in Nitroglycerin-treated Mice.
Mitral Valve Insufficiency
[Study on the total activity of PKC and the quantity of PKC (alpha, beta) in left auricle tissues of the patients with mitral disease and atrial fibrillation]
Mitral Valve Stenosis
[Study on the total activity of PKC and the quantity of PKC (alpha, beta) in left auricle tissues of the patients with mitral disease and atrial fibrillation]
Mononeuropathies
Increases in protein kinase C gamma immunoreactivity in the spinal cord dorsal horn of rats with painful mononeuropathy.
Mononeuropathies
Spatial patterns of increased spinal cord membrane-bound protein kinase C and their relation to increases in 14C-2-deoxyglucose metabolic activity in rats with painful peripheral mononeuropathy.
Motor Neuron Disease
Aberrant deltaPKC activation in the spinal cord of Wobbler mouse: a model of motor neuron disease.
Motor Neuron Disease
Activation of NMDA receptors and Ca2+/calmodulin-dependent protein kinase participate in phosphorylation of neurofilaments induced by protein kinase C.
Mouth Neoplasms
Effect of protein kinase C alpha, caspase-3, and survivin on apoptosis of oral cancer cells induced by staurosporine.
Mouth Neoplasms
Indoleamine 2,3-dioxygenase, an immunomodulatory protein, is suppressed by (-)-epigallocatechin-3-gallate via blocking of gamma-interferon-induced JAK-PKC-delta-STAT1 signaling in human oral cancer cells.
Mouth Neoplasms
Matrix metalloproteinase 2 and matrix metalloproteinase 9 expression in human oral squamous cell carcinoma and the effect of protein kinase C inhibitors: preliminary observations.
Mucolipidoses
Inhibition of protein kinase C activity in mucolipidosis type-4: a model for a new pathogenetic mechanism in inborn errors of metabolism.
Mucolipidoses
Protein kinase C activation and phosphate uptake are altered in intact mucolipidosis type-4 skin fibroblasts.
Mucopolysaccharidoses
Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency.
Multiple Myeloma
A Multicenter Phase II Study of Single-agent Enzastaurin in Previously Treated Multiple Myeloma.
Multiple Myeloma
Apoptin interacts with and regulates the activity of protein kinase C beta in cancer cells.
Multiple Myeloma
GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Multiple Myeloma
Inhibitors of protein kinase C sensitise multiple myeloma cells to common genotoxic drugs.
Multiple Myeloma
Molecular targeting of the PKC-beta inhibitor enzastaurin (LY317615) in multiple myeloma involves a coordinated downregulation of MYC and IRF4 expression.
Multiple Myeloma
PKC412 demonstrates JNK-dependent activity against human multiple myeloma cells.
Multiple Myeloma
Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis.
Multiple Myeloma
Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl).
Multiple Myeloma
Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation.
Multiple Sclerosis
Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population.
Multiple Sclerosis
Functional variations modulating PRKCA expression and alternative splicing predispose to multiple sclerosis.
Multiple Sclerosis
Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages.
Multiple Sclerosis
No evidence for association of the protein kinase C alpha gene with multiple sclerosis.
Multiple Sclerosis
Protein kinase C polymorphisms and vitamin D levels in multiple sclerosis.
Multiple Sclerosis
Small molecule inhibitors of PKCTheta as potential antiinflammatory therapeutics.
Multiple Sclerosis
The activation of protein kinase C induces higher production of reactive oxygen species by mononuclear cells in patients with multiple sclerosis than in controls.
Multiple System Atrophy
Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies.
Muscle Spasticity
Alterations in protein kinase C activity and membrane lipid metabolism in cerebral vasospasm after subarachnoid hemorrhage.
Muscle Spasticity
Diltiazem Inhibits Coronary Spasm via Inhibition of Cav1.2Phosphorylation and Protein Kinase C Activation in a Mouse Model of Coronary Spastic Angina.
Muscle Spasticity
Effects of inhibitors of protein kinase C and calpain in experimental delayed cerebral vasospasm.
Muscle Spasticity
Generation of the catalytic fragment of protein kinase C alpha in spastic canine basilar artery.
Muscular Atrophy
Microgravity-Induced Transcriptome Adaptation in Mouse Paraspinal longissimus dorsi Muscle Highlights Insulin Resistance-Linked Genes.
Muscular Diseases
Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat.
Muscular Diseases
Expression of protein kinase C isoforms and interleukin-1beta in myofibrillar myopathy.
Muscular Diseases
Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neuronal and myogenic mechanisms.
Muscular Dystrophies
PKC Theta Ablation Improves Healing in a Mouse Model of Muscular Dystrophy.
Muscular Dystrophy, Duchenne
Altered protein kinase C and protein kinase A activities in erythrocyte membrane, platelets and lymphocytes of Duchenne muscular dystrophy (DMD) patients.
Muscular Dystrophy, Duchenne
Clinical implications of basic neuroscience research. I: Protein kinases, ionic channels, and genes.
Muscular Dystrophy, Duchenne
Importance of monitoring calcium & calcium related properties in carrier detection for Duchenne muscular dystrophy.
Myalgia
Bryostatin 1, a novel antineoplastic agent and protein kinase C activator, induces human myalgia and muscle metabolic defects: a 31P magnetic resonance spectroscopic study.
Myalgia
Modulation of bryostatin 1 muscle toxicity by nifedipine: effects on muscle metabolism and oxygen supply.
Myalgia
Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms.
Myalgia
Spinal protein kinase C/extracellular signal-regulated kinase signal pathway mediates hyperalgesia priming.
Myasthenia Gravis
AEB-071 Ameliorates Muscle Weakness by Altering Helper T Lymphocytes in an Experimental Autoimmune Myasthenia Gravis Rat Model.
Myasthenia Gravis
Antigen-specific T-cell activation in hyperplastic thymus in myasthenia gravis.
Myasthenia Gravis
Concanavalin A- or phorbol ester-induced translocation of protein kinase C in thymoma cells from a patient with myasthenia gravis.
Mycoses
Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade.
Myocardial Infarction
Activating mu-opioid receptors in the spinal cord mediates the cardioprotective effect of remote preconditioning of trauma.
Myocardial Infarction
Activation of mitochondrial K(ATP) channel elicits late preconditioning against myocardial infarction via protein kinase C signaling pathway.
Myocardial Infarction
Brief pressure overload of the left ventricle reduces myocardial infarct size via activation of protein kinase C.
Myocardial Infarction
Cardioprotection after angiotensin II type 1 blockade involves angiotensin II type 2 receptor expression and activation of protein kinase C-epsilon in acutely reperfused myocardial infarction in the dog. Effect of UP269-6 and losartan on AT1 and AT2-receptor expression and IP3 receptor and PKCepsilon proteins.
Myocardial Infarction
Cardioprotection induced by AT1R blockade after reperfused myocardial infarction: association with regional increase in AT2R, IP3R and PKCepsilon proteins and cGMP.
Myocardial Infarction
Diabetes and Complications: Cellular Signalling Pathways, Current Understanding and Targeted Therapies.
Myocardial Infarction
Dietary polyunsaturated fatty acids alter myocardial protein kinase C expression and affect cardioprotection induced by chronic hypoxia.
Myocardial Infarction
Essential activation of PKC-delta in opioid-initiated cardioprotection.
Myocardial Infarction
Increased expression of protein kinase C isoforms in heart failure due to myocardial infarction.
Myocardial Infarction
Inhibition of Protein Kinase C ? Ameliorates Impaired Angiogenesis in Type I Diabetic Mice Complicating Myocardial Infarction.
Myocardial Infarction
Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction.
Myocardial Infarction
Ischemia induced activation of heat shock protein 27 kinases and casein kinase 2 in the preconditioned rabbit heart.
Myocardial Infarction
Ischemic preconditioning improves proteasomal activity and increases the degradation of {delta}PKC during reperfusion.
Myocardial Infarction
K(ATP) channel agonists preserve connexin43 protein in infarcted rats by a protein kinase c-dependent pathway.
Myocardial Infarction
Limitation of myocardial infarct size by adenosine A1 receptor activation is abolished by protein kinase C inhibitors in the rabbit.
Myocardial Infarction
Mechanisms of myocardial ischemic preconditioning are age related: PKC-epsilon does not play a requisite role in old rabbits.
Myocardial Infarction
Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury.
Myocardial Infarction
NO donor-activated PKC-delta plays a pivotal role in ischemic myocardial protection through accelerated opening of mitochondrial K-ATP channels.
Myocardial Infarction
Overexpression of protein kinase C ? improves retention and survival of transplanted mesenchymal stem cells in rat acute myocardial infarction.
Myocardial Infarction
PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway.
Myocardial Infarction
Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model.
Myocardial Infarction
Pharmacological preconditioning in type 2 diabetic rat hearts: the roles of mitochondrial ATP-sensitive potassium channels and the phosphatidylinositol 3-kinase-Akt pathway.
Myocardial Infarction
Platelet expression of PKCepsilon oncoprotein in myelofibrosis is associated with disease severity and thrombotic risk.
Myocardial Infarction
Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis.
Myocardial Infarction
Preserved coronary endothelial function by inhibition of delta protein kinase C in a porcine acute myocardial infarction model.
Myocardial Infarction
Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts.
Myocardial Infarction
Protein kinase C ? expression in platelets from patients with acute myocardial infarction.
Myocardial Infarction
Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function.
Myocardial Infarction
Protein kinase C is involved in resistance to myocardial infarction induced by heat stress.
Myocardial Infarction
Protein Kinases as Drug Development Targets for Heart Disease Therapy.
Myocardial Infarction
Reduction of myocardial injury by the EP3 receptor agonist TEI-3356. Role of protein kinase C and of K(ATP)-channels.
Myocardial Infarction
Regional and temporal profiles of phorbol 12,13-dibutyrate binding after myocardial infarction in rats: effects of captopril treatment.
Myocardial Infarction
Regulation of the isozymes of protein kinase C in the surviving rat myocardium after myocardial infarction: distinct modulation for PKC-alpha and for PKC-delta.
Myocardial Infarction
Selective activation of the prostanoid EP(3) receptor reduces myocardial infarct size in rodents.
Myocardial Infarction
Sensitization of the beta-adrenergic system in acute myocardial ischaemia by a protein kinase C-dependent mechanism.
Myocardial Infarction
The infarct size-limiting effect of ischemic postconditioning (IPOC) is suppressed in isolated hyperhomocysteinemic (Hhcy) rat hearts: the reasonable role of PKC-delta.
Myocardial Infarction
The role of serotonin in ischemic cellular damage and the infarct size-reducing effect of sarpogrelate, a 5-hydroxytryptamine-2 receptor blocker, in rabbit hearts.
Myocardial Infarction
Time Courses of Subcellular Signal Transduction and Cellular Apoptosis in Remote Viable Myocardium of Rat Left Ventricles Following Acute Myocardial Infarction: Role of Pharmacomodulation.
Myocardial Infarction
Treatment with sheng-mai-san reduces myocardial infarct size through activation of protein kinase C and opening of mitochondrial KATP channel.
Myocardial Ischemia
Activation of myocardial protein kinase C by plasmalogenic diglycerides.
Myocardial Ischemia
Adenosine induced direct negative inotropic effect is abolished during global ischemia: role of protein kinase C and prostacyclin.
Myocardial Ischemia
Alpha 1-receptor-independent activation of protein kinase C in acute myocardial ischemia. Mechanisms for sensitization of the adenylyl cyclase system.
Myocardial Ischemia
Association of the phosphatidylinositol signal pathway with prolonged myocardial ischemia.
Myocardial Ischemia
Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury.
Myocardial Ischemia
Cardiopulmonary bypass with cardioplegic arrest activates protein kinase C in the human myocardium.
Myocardial Ischemia
Deletion of protein kinase C-epsilon signaling pathway induces glomerulosclerosis and tubulointerstitial fibrosis in vivo.
Myocardial Ischemia
Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium.
Myocardial Ischemia
Dual mechanism of autoregulation of protein kinase C in myocardial ischemia.
Myocardial Ischemia
Identification of specific nuclear protein kinase C isozymes and accelerated protein kinase C-dependent nuclear protein phosphorylation during myocardial ischemia.
Myocardial Ischemia
Intestinal ischemia preconditions myocardium: role of protein kinase C and mitochondrial K(ATP) channel.
Myocardial Ischemia
Ischemic preconditioning upregulates vascular endothelial growth factor mRNA expression and neovascularization via nuclear translocation of protein kinase C epsilon in the rat ischemic myocardium.
Myocardial Ischemia
Ischemic protection and myofibrillar cardiomyopathy: dose-dependent effects of in vivo deltaPKC inhibition.
Myocardial Ischemia
Nitric oxide induces heat shock protein 72 production and delayed protection against myocardial ischemia in rabbits via activating protein kinase C.
Myocardial Ischemia
PKCepsilon activation induces dichotomous cardiac phenotypes and modulates PKCepsilon-RACK interactions and RACK expression.
Myocardial Ischemia
Post-ischemic PKC inhibition impairs myocardial calcium handling and increases contractile protein calcium sensitivity.
Myocardial Ischemia
Preconditioning protects ischemic rabbit heart by protein kinase C activation.
Myocardial Ischemia
Protective effects of protein kinase C during myocardial ischemia require activation of phosphatidyl-inositol specific phospholipase C.
Myocardial Ischemia
Protein kinase C expression and subcellular distribution in chronic myocardial ischemia. Comparison of two different canine models.
Myocardial Ischemia
Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia.
Myocardial Ischemia
Protein kinase C-epsilon is a trigger of delayed cardioprotection against myocardial ischemia of kappa-opioid receptor stimulation in rat ventricular myocytes.
Myocardial Ischemia
Reciprocal regulation between M(3) muscarinic acetylcholine receptor and protein kinase C-epsilon in ventricular myocytes during myocardial ischemia in rats.
Myocardial Ischemia
Responses of cardiac protein kinase C isoforms to distinct pathological stimuli are differentially regulated.
Myocardial Ischemia
Role of intracellular Ca2+ in activation of protein kinase C during ischemic preconditioning.
Myocardial Ischemia
Two distinct mechanisms mediate a differential regulation of protein kinase C isozymes in acute and prolonged myocardial ischemia.
Myocardial Ischemia
[Effect of Electroacupuncture Stimulation of "Neiguan" (PC 6) on Expression of Myocardial Chloride Channel-related Genes, PKC and PKG Proteins in Myocardial Ischemia Rats].
Myocardial Ischemia
[Remote postconditioning by brief renal ischemia and reperfusion reduces acute myocardial ischemia and reperfusion induced myocardial apoptosis in rabbits]
Myocardial Reperfusion Injury
Moderate alcohol consumption induces sustained cardiac protection by activating PKC-epsilon and Akt.
Myocardial Reperfusion Injury
Pharmacological strategies to contend against myocardial reperfusion damage: diverse chemicals for multiple targets.
Myocardial Stunning
Direct evidence that protein kinase C plays an essential role in the development of late preconditioning against myocardial stunning in conscious rabbits and that epsilon is the isoform involved.
Myocardial Stunning
Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection.
Myocardial Stunning
Isoflurane-enhanced recovery of canine stunned myocardium: role for protein kinase C?
Myocardial Stunning
Phosphorylation by protein kinase C and the responsiveness of Mg(2+)-ATPase to Ca2+ of myofibrils isolated from stunned and non-stunned porcine myocardium.
Myosarcoma
Synergistic effects of adenosine A1 and P2Y receptor stimulation on calcium mobilization and PKC translocation in DDT1 MF-2 cells.
Myotonia
Activators of protein kinase C induce myotonia by lowering chloride conductance in muscle.
Myotonic Dystrophy
Linkage relationships of the protein kinase C gamma gene which exclude it as a candidate for myotonic dystrophy.
nad(p)h oxidase (h2o2-forming) deficiency
Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen Species-Studies in White Blood Cells and in Animal Models.
Nasal Polyps
Protein kinase C in proliferation and infiltration of eosinophils in nasal polyp.
Nasal Polyps
[Protein kinase C in eosinophil proliferation and infiltration in nasal polyp tissue]
Nasal Polyps
[The influence of protein kinase C inhibitor in eosinophil apoptosis of nasal polyps]
Nasal Polyps
[The regulation of PKCalpha in eosinophil infiltration and proliferation in nasal polyps]
Nasopharyngeal Carcinoma
A novel approach for nasopharyngeal carcinoma treatment uses phenylbutyrate as a protein kinase C modulator: implications for radiosensitization and EBV-targeted therapy.
Nasopharyngeal Carcinoma
Microtubule depolymerization activates the Epstein-Barr virus lytic cycle through protein kinase C pathways in nasopharyngeal carcinoma cells.
Nasopharyngeal Carcinoma
N,N'-dinitrosopiperazine-mediated ezrin protein phosphorylation via activation of Rho kinase and protein kinase C is involved in metastasis of nasopharyngeal carcinoma 6-10B cells.
Nasopharyngeal Carcinoma
PKC? is a Potentially Useful Marker for Planning Individualized Radiotherapy for Nasopharyngeal Carcinoma.
Nasopharyngeal Carcinoma
Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus.
Nasopharyngeal Carcinoma
Telomerase is regulated by protein kinase C-zeta in human nasopharyngeal cancer cells.
Nasopharyngeal Neoplasms
Cdc42/Rac1 participates in the control of telomerase activity in human nasopharyngeal cancer cells.
Nasopharyngeal Neoplasms
Telomerase is regulated by protein kinase C-zeta in human nasopharyngeal cancer cells.
Neoplasm Metastasis
Activation of protein kinase C-alpha isoform in murine melanoma cells with high metastatic potential.
Neoplasm Metastasis
Analyses of protein kinase C isoform expression in a colorectal cancer liver metastasis model.
Neoplasm Metastasis
Clustering of murine lung metastases reflects fractal nonuniformity in regional lung blood flow.
Neoplasm Metastasis
Combination therapy of PKC? and COX-2 inhibitors synergistically suppress melanoma metastasis.
Neoplasm Metastasis
Control of MT1-MMP transport by atypical PKC during breast-cancer progression.
Neoplasm Metastasis
Cytoprotective effects of N,N,N-trimethylsphingosine during ischemia- reperfusion injury are lost in the setting of obesity and diabetes.
Neoplasm Metastasis
Distinct mechanisms mediate the initial and sustained phases of cell migration in epidermal growth factor receptor-overexpressing cells.
Neoplasm Metastasis
Down-regulation of PKCzeta expression inhibits chemotaxis signal transduction in human lung cancer cells.
Neoplasm Metastasis
Dual Actin-bundling and Protein Kinase C-binding Activities of Fascin Regulate Carcinoma Cell Migration Downstream of Rac and Contribute to Metastasis.
Neoplasm Metastasis
Effect of PKC412, a selective inhibitor of protein kinase C, on lung metastasis in mice injected with B16 melanoma cells.
Neoplasm Metastasis
Effect of protein kinase C activating tumor promoters on metastases formation by fibrosarcoma cells.
Neoplasm Metastasis
Effect of staurosporine on N-glycosylation and cell adhesion to fibronectin of SW480 human colorectal adenocarcinoma cells.
Neoplasm Metastasis
Effects of cell membrane phospholipid level and protein kinase C isoenzyme expression on hepatic metastasis of colorectal carcinoma.
Neoplasm Metastasis
Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.
Neoplasm Metastasis
Fish oil may impede tumour angiogenesis and invasiveness by down-regulating protein kinase C and modulating eicosanoid production.
Neoplasm Metastasis
Genetic Ablation of PKC Epsilon Inhibits Prostate Cancer Development and Metastasis in Transgenic Mouse Model of Prostate Adenocarcinoma.
Neoplasm Metastasis
Homophilic complex formation of CDCP1 via the extracellular CUB2 domain facilitates SFK activation and promotes cancer cell migration.
Neoplasm Metastasis
Human melanoma metastasis is inhibited following ex vivo treatment with an antisense oligonucleotide to protein kinase C-alpha.
Neoplasm Metastasis
Inhibition of experimental metastasis and cell adhesion of B16F1 melanoma cells by inhibitors of protein kinase C.
Neoplasm Metastasis
Inhibition of protein kinase C activity inhibits osteosarcoma metastasis.
Neoplasm Metastasis
Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo.
Neoplasm Metastasis
KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha.
Neoplasm Metastasis
Localization of PKC? in Cell Membranes as a Predictor for Breast Cancer Response to Treatment.
Neoplasm Metastasis
Modulation of human melanoma cell metastasis and adhesion may involve integrin phosphorylation mediated through protein kinase C.
Neoplasm Metastasis
mTOR in renal cell cancer: modulator of tumor biology and therapeutic target.
Neoplasm Metastasis
N,N'-dinitrosopiperazine-mediated ezrin protein phosphorylation via activation of Rho kinase and protein kinase C is involved in metastasis of nasopharyngeal carcinoma 6-10B cells.
Neoplasm Metastasis
Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model.
Neoplasm Metastasis
Overexpression of PAK-1 is an independent predictor of disease recurrence in colorectal carcinoma.
Neoplasm Metastasis
Overexpression of protein kinase C-zeta (PKC-zeta) inhibits invasive and metastatic abilities of Dunning R-3327 MAT-LyLu rat prostate cancer cells.
Neoplasm Metastasis
Overexpression of protein kinase Calpha mRNA may be an independent prognostic marker for gastric carcinoma.
Neoplasm Metastasis
p38 mitogen-activated protein kinase pathway is involved in protein kinase Calpha-regulated invasion in human hepatocellular carcinoma cells.
Neoplasm Metastasis
Pak-1 expression increases with progression of colorectal carcinomas to metastasis.
Neoplasm Metastasis
Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37.
Neoplasm Metastasis
PKC-delta binds to E-cadherin and mediates EGF-induced cell scattering.
Neoplasm Metastasis
PKC? in prostate cancer cells represses the recruitment and M2 polarization of macrophages in the prostate cancer microenvironment.
Neoplasm Metastasis
Possible involvement of Ca2+ mobilization and protein kinase C activation in the induction of spontaneous metastasis by mouse mammary adenocarcinoma cells.
Neoplasm Metastasis
Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells.
Neoplasm Metastasis
Preclinical studies of molecular-targeting diagnostic and therapeutic strategies against breast cancer.
Neoplasm Metastasis
Proliferation of human breast cancer cells and anti-cancer action of doxorubicin and vinblastine are independent of PKC-alpha.
Neoplasm Metastasis
Protein interacting with C alpha kinase 1 (PICK1) is involved in promoting tumor growth and correlates with poor prognosis of human breast cancer.
Neoplasm Metastasis
Protein kinase C ? enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin.
Neoplasm Metastasis
Protein kinase C epsilon and genetic networks in osteosarcoma metastasis.
Neoplasm Metastasis
Protein kinase C is inhibited by bisphosphonates in prostate cancer PC-3 cells.
Neoplasm Metastasis
Protein kinase C isoforms in normal and transformed cells of the melanocytic lineage.
Neoplasm Metastasis
Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation.
Neoplasm Metastasis
Protein kinase C: a novel target for inhibiting gastric cancer cell invasion.
Neoplasm Metastasis
Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis.
Neoplasm Metastasis
Protein Kinase C{epsilon} Mediates Polymeric Fibronectin Assembly on the Surface of Blood-borne Rat Breast Cancer Cells to Promote Pulmonary Metastasis.
Neoplasm Metastasis
Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts.
Neoplasm Metastasis
Role of ellagic acid in regulation of apoptosis by modulating novel and atypical PKC in lymphoma bearing mice.
Neoplasm Metastasis
Roles of partitioning-defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells.
Neoplasm Metastasis
Scanning electrochemical microscopy: detection of human breast cancer cells by redox environment.
Neoplasm Metastasis
Screening of a PKC zeta-specific kinase inhibitor PKCzI257.3 which inhibits EGF-induced breast cancer cell chemotaxis.
Neoplasm Metastasis
SSeCKS metastasis-suppressing activity in MatLyLu prostate cancer cells correlates with vascular endothelial growth factor inhibition.
Neoplasm Metastasis
Sustained inhibition of PKC? reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model.
Neoplasm Metastasis
The Atypical Protein Kinase C Small Molecule Inhibitor ?-Stat, and Its Effects on Invasion Through Decreases in PKC-? Protein Expression.
Neoplasm Metastasis
The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells.
Neoplasm Metastasis
The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2.
Neoplasm Metastasis
The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).
Neoplasm Metastasis
The TGF-? signalling negative regulator PICK1 represses prostate cancer metastasis to bone.
Neoplasm Metastasis
The therapeutic role of targeting protein kinase C in solid and hematologic malignancies.
Neoplasm Metastasis
Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells.
Neoplasm Metastasis
Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism.
Neoplasm Metastasis
Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis.
Neoplasm Metastasis
WNT5A-Induced Activation of the Protein Kinase C Substrate MARCKS Is Required for Melanoma Cell Invasion.
Neoplasm Metastasis
[An experimental study on the capability of laminin receptor antibody and protein kinase C inhibitor to inhibit tumor metastasis in vivo]
Neoplasm Metastasis
[Cell membrane phospholipid variation and protein kinase C expression effects on hepatic metastasis of large intestinal carcinoma]
Neoplasm Metastasis
[Expressions of five protein kinase C isoforms in salivary adenoid cystic carcinoma]
Neoplasm Metastasis
[Inhibition of experimental metastasis and cell adhesion of B16 murine melanoma cells by protein kinase C inhibitor CJ9111]
Neoplasm Metastasis
[The variation of intracellular distribution and translocation of the protein kinase C alpha among human lung cancer cell line with different metastasis potential.]
Neoplasms
(1)H, (13)C and (15)N NMR assignments of the C1A and C1B subdomains of PKC-delta.
Neoplasms
1-dehydro-melengestrol acetate inhibits the growth and protein kinase C activity of androgen-independent Dunning rat prostatic tumors.
Neoplasms
12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha.
Neoplasms
12(S)-HETE increases the motility of prostate tumor cells through selective activation of PKC alpha.
Neoplasms
12-Deoxyphorbol Esters Induce Growth Arrest and Apoptosis in Human Lung Cancer A549 Cells Via Activation of PKC-?/PKD/ERK Signaling Pathway.
Neoplasms
12-O-retinoylphorbol-13-acetate (RPA) behaves like a retinoid-derivative in binding to retinol-binding-protein: a correlation with its specific action as an incomplete tumor promoter?
Neoplasms
12-O-tetradecanoylphorbol-13-acetate and staurosporine induce increased retinoblastoma tumor suppressor gene expression with megakaryocytic differentiation of leukemic cells.
Neoplasms
12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin 8 Phosphorylation and Reorganization via Expression of Transglutaminase-2.
Neoplasms
12-O-tetradecanoylphorbol-13-acetate stimulates phosphorylation of the 58,000-Mr form of polyomavirus middle T antigen in vivo: implications for a possible role of protein kinase C in middle T function.
Neoplasms
12-O-tetradecanoylphorbol-13-acetate, a phorbol ester stimulating protein kinase C, inhibits bone resorption in vitro induced by parathyroid hormone and parathyroid hormone-related peptide of malignancy.
Neoplasms
14-3-3? promotes lung cancer cell invasion by increasing the Snail protein expression through atypical protein kinase C (aPKC)/NF-?B signaling.
Neoplasms
1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase.
Neoplasms
60-Hz electric fields inhibit protein kinase C activity and multidrug resistance gene (MDR1) up-regulation.
Neoplasms
A 150-kDa glycoprotein isolated from Solanum nigrum L. has cytotoxic and apoptotic effects by inhibiting the effects of protein kinase C alpha, nuclear factor-kappa B and inducible nitric oxide in HCT-116 cells.
Neoplasms
A Case of KIT-Negative Extra-Gastrointestinal Stromal Tumor of the Lesser Omentum.
Neoplasms
A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle.
Neoplasms
A metabolite of an antineoplastic ether phospholipid may inhibit transmembrane signalling via protein kinase C.
Neoplasms
A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters.
Neoplasms
A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma.
Neoplasms
A multiple cytokine- and second messenger-responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation.
Neoplasms
A new concept of tumor promotion by tumor necrosis factor-alpha, and cancer preventive agents (-)-epigallocatechin gallate and green tea--a review.
Neoplasms
A new concise synthesis of arcyriacyanin A and its unique inhibitory activity against a panel of human cancer cell line.
Neoplasms
A new PKC?/?/TBX3/E-cadherin pathway is involved in PLC?-regulated invasion and migration in human bladder cancer cells.
Neoplasms
A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1.
Neoplasms
A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKC? and E-cadherin.
Neoplasms
A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin.
Neoplasms
A novel pathway responsible for lipopolysaccharide-induced translational regulation of TNF-? and IL-6 expression involves protein kinase C and fascin.
Neoplasms
A novel PKC-? inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma.
Neoplasms
A novel requirement for Janus kinases as mediators of drug resistance induced by fibroblast growth factor-2 in human cancer cells.
Neoplasms
A novel succinyl dipeptide stimulates directed cell migration by modulating protein kinase C activity.
Neoplasms
A phase I trial of aprinocarsen (ISIS 3521/LY900003), an antisense inhibitor of protein kinase C-alpha administered as a 24-hour weekly infusion schedule in patients with advanced cancer.
Neoplasms
A phase I trial of bryostatin 1 in patients with advanced malignancy using a 24 hour intravenous infusion.
Neoplasms
A phase II study of bryostatin-1 and paclitaxel in patients with advanced non-small cell lung cancer.
Neoplasms
A Phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C alpha, administered as a 21-day infusion to patients with advanced ovarian carcinoma.
Neoplasms
A phase II trial of bryostatin 1 in the treatment of metastatic colorectal cancer.
Neoplasms
A protective role of PKCepsilon against TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in glioma cells.
Neoplasms
A protein kinase C agonist, selective for the beta I isozyme, induces E-selectin and VCAM-1 expression on HUVEC but does not translocate PKC.
Neoplasms
A protein kinase C inhibitor induces phenotypic reversion of ras-transformed pancreatic cancer cells and cooperatively blocks tumor cell proliferation with an anti- ras peptide.
Neoplasms
A protein kinase Cbeta inhibitor attenuates multidrug resistance of neuroblastoma cells.
Neoplasms
A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer.
Neoplasms
A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle.
Neoplasms
A role for PKCzeta in potentiation of the topoisomerase II activity and etoposide cytotoxicity by wortmannin.
Neoplasms
A role for SSeCKS, a major protein kinase C substrate with tumour suppressor activity, in cytoskeletal architecture, formation of migratory processes, and cell migration during embryogenesis.
Neoplasms
A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity.
Neoplasms
A systematic review and meta-analysis of prognostic biomarkers in resectable esophageal adenocarcinomas.
Neoplasms
A tumor promoter-resistant subpopulation of progenitor cells is larger in limbal epithelium than in corneal epithelium.
Neoplasms
A window of opportunity phase II study of enzastaurin in chemonaive patients with asymptomatic metastatic colorectal cancer.
Neoplasms
Aberrant expression of epidermal growth factor receptor and its interaction with protein kinase C ? in inflammation associated neoplastic transformation of human esophageal epithelium in high risk populations.
Neoplasms
Ability of okadaic acid and other protein phosphatase inhibitors to mimic the stimulatory effects of 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production in mouse epidermis in vivo.
Neoplasms
Ability of the non-phorbol ester-type tumor-promoter thapsigargin to mimic the stimulatory effects of 12-0-tetradecanoylphorbol-13-acetate on ornithine decarboxylase activity, hydroperoxide production, and macromolecule synthesis in mouse epidermis in vivo.
Neoplasms
Abnormal calcium and protein kinase C-epsilon signaling in hypertrophied atrial tumor myocytes (AT-1 cells).
Neoplasms
Abnormal T cells from MRL/Mp-lpr/lpr mice do not respond to anti-T-cell-receptor antibody or tumor promoter and calcium ionophore A23187 despite the presence of the T-cell-receptor complex and protein kinase c.
Neoplasms
Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function.
Neoplasms
Absence of synergistic effects on tumor promotion in CD-1 mouse skin by simultaneous applications of two different types of tumor promoters, okadaic acid and teleocidin.
Neoplasms
Action of a phorbol ester on B-cells: potentiation of stimulant-induced electrical activity.
Neoplasms
Actions of a tumor-promoting phorbol ester in a cloned rat pituitary cell : Potential involvement of changes in Ca(2+) metabolism.
Neoplasms
Activated PKCalpha/ERK1/2 signaling inhibits tamoxifen-induced apoptosis in C6 cells.
Neoplasms
Activation by Tyrosine Phosphorylation as a Prerequisite for Protein Kinase C{zeta} to Mediate Epidermal Growth Factor Receptor Signaling to ERK.
Neoplasms
Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis.
Neoplasms
Activation of atypical protein kinase C zeta by caspase processing and degradation by the ubiquitin-proteasome system.
Neoplasms
Activation of calcium-activated, phospholipid-dependent protein kinase (protein kinase C) by new classes of tumor promoters: teleocidin and debromoaplysiatoxin.
Neoplasms
Activation of conventional PKC isoforms increases expression of the pro-apoptotic protein Bad and TRAIL receptors.
Neoplasms
Activation of cyclic AMP phosphodiesterase by phorbol and protein kinase C pathway: differences in normal and diabetic tissue.
Neoplasms
Activation of distinct second messenger systems in anterior pituitary corticotrophic tumor cells alters the phosphorylation states of both shared and distinct cytosolic proteins.
Neoplasms
Activation of human leukemia protein kinase C by tumor promoters and its inhibition by N-trifluoroacetyladriamycin-14-valerate (AD 32).
Neoplasms
Activation of microvascular endothelium by eicosanoid 12(S)-hydroxyeicosatetraenoic acid leads to enhanced tumor cell adhesion via up-regulation of surface expression of alpha v beta 3 integrin: a posttranscriptional, protein kinase C- and cytoskeleton-dependent process.
Neoplasms
Activation of NADPH-oxidase and its associated whole-cell H+ current in human neutrophils by recombinant human tumor necrosis factor alpha and formyl-methionyl-leucyl-phenylalanine.
Neoplasms
Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain.
Neoplasms
Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes.
Neoplasms
Activation of protein kinase C and specific phosphorylation of a Mr 90,000 membrane protein of promotable BALB/3T3 and C3H/10T1/2 cells by tumor promoters.
Neoplasms
Activation of protein kinase C by ganglioside GM3 in the presence of calcium and 12-O-tetradecanoylphorbol-13-acetate.
Neoplasms
Activation of protein kinase C by mycobacterial cord factor, trehalose 6-monomycolate, resulting in tumor necrosis factor-alpha release in mouse lung tissues.
Neoplasms
Activation of protein kinase C by tumor necrosis factor-alpha in human non-pigmented ciliary epithelium.
Neoplasms
Activation of protein kinase C by tumor promoting phorbol esters, teleocidin and aplysiatoxin in the absence of added calcium.
Neoplasms
Activation of protein kinase C during cell volume regulation in Ehrlich mouse ascites tumor cells.
Neoplasms
Activation of protein kinase C mediates altered pulmonary vasoreactivity induced by tumor necrosis factor-alpha.
Neoplasms
Activation of protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c).
Neoplasms
Activation of protein kinase C rapidly down-regulates naloxone-resistant receptors for beta-endorphin on U937 cells.
Neoplasms
Activation of protein kinase C subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents.
Neoplasms
Activation of protein kinase C via the T-cell receptor complex potentiates cyclic AMP responses in T-cells.
Neoplasms
Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta.
Neoplasms
Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor.
Neoplasms
Activation of the integrin effector kinase focal adhesion kinase in cancer cells is regulated by crosstalk between protein kinase Calpha and the PDZ adapter protein mda-9/Syntenin.
Neoplasms
Activators of protein kinase C induce dissociation of CD4, but not CD8, from p56lck.
Neoplasms
Activity of high-dose toremifene plus cisplatin in platinum-treated non-small-cell lung cancer: a phase II California Cancer Consortium Trial.
Neoplasms
Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones.
Neoplasms
Agents that activate protein kinase C reduce acetylcholine sensitivity in cultured myotubes.
Neoplasms
AKAP12 induces apoptotic cell death in human fibrosarcoma cells by regulating CDKI-cyclin D1 and caspase-3 activity.
Neoplasms
Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cells.
Neoplasms
Alkyl Cinnamates Induce Protein Kinase C Translocation and Anticancer Activity against Breast Cancer Cells through Induction of the Mitochondrial Pathway of Apoptosis.
Neoplasms
All-trans retinoic acid and protein kinase C ?/?1 inhibitor combined treatment targets cancer stem cells and impairs breast tumor progression.
Neoplasms
Allergy-related cytokines (IL-4 and TNF-alpha) are induced by Di(2-ethylhexyl) phthalate and attenuated by plant-originated glycoprotein (75 kDa) in HMC-1 cells.
Neoplasms
alpha-Synuclein stimulates differentiation of osteosarcoma cells: relevance to down-regulation of proteasome activity.
Neoplasms
Alteration in the expression of protein kinase C isoforms in human hepatocellular carcinoma.
Neoplasms
Alterations in protein kinase C in 1,2-dimethylhydrazine induced colonic carcinogenesis.
Neoplasms
Alterations in the activity and regulation of mammalian ribonucleotide reductase by chlorambucil, a DNA damaging agent.
Neoplasms
Alterations in the cyclic AMP signal transduction pathway regulating ribonucleotide reductase gene expression in malignant H-ras transformed cell lines.
Neoplasms
Altered expression of transforming growth factor-beta 1 mRNA and protein in mouse skin carcinogenesis.
Neoplasms
Altered function of protein kinase C and cyclic adenosine monophosphate-dependent protein kinase in a cell line derived from a mouse lung papillary tumor.
Neoplasms
Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas.
Neoplasms
Altered subcellular distribution of protein kinase C (a phorbol ester receptor). Possible role in tumor promotion and the regulation of cell growth: relationship to changes in adenylate cyclase activity.
Neoplasms
An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms.
Neoplasms
An anti-inflammatory benzamide derivative inhibits the protein kinase C (PKC)-dependent pathway of ERK2 phosphorylation in murine macrophages.
Neoplasms
An endothelial cell model for the investigation of the molecular regulation of fetal vascular tone.
Neoplasms
An immunohistochemical study of glucagonoma conducted on the metastatic lymph nodes from a patient with recurrent metastatic glucagonoma: report of a case.
Neoplasms
An inhibitory role for the protein kinase C pathway in ovarian steroidogenesis. Studies with cultured swine granulosa cells.
Neoplasms
Analytical procedure for the determination of the new antitumour drug N-benzoylstaurosporine and three potential metabolites in human plasma by reversed-phase high-performance liquid chromatography.
Neoplasms
Angiotensin type 1a receptor signaling-dependent induction of vascular endothelial growth factor in stroma is relevant to tumor-associated angiogenesis and tumor growth.
Neoplasms
Annexin A2 is involved in activation of extracellular signal-regulated kinase upon endothelin-1 stimulation.
Neoplasms
Antagonistic control of tumor necrosis factor receptors by protein kinases A and C. Enhancement of TNF receptor synthesis by protein kinase A and transmodulation of receptors by protein kinase C.
Neoplasms
Antagonistic effects of phorbol esters on lymphocyte activation. Evidence that protein kinase C provides an early signal associated with lytic function.
Neoplasms
Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor.
Neoplasms
Antagonistic growth regulation of cell lines derived from human lung adenocarcinomas of Clara cell and aveolar type II cell lineage: Implications for chemoprevention.
Neoplasms
Antagonists of bombesin/gastrin-releasing peptide decrease the expression of angiogenic and anti-apoptotic factors in human glioblastoma.
Neoplasms
Anti-cancer effects of morphine through inhibition of tumour necrosis factor-alpha release and mRNA expression.
Neoplasms
Anti-proliferative effect of two novel palmitoyl-carnitine analogs, selective inhibitors of protein kinase C conventional isoenzymes.
Neoplasms
Antibodies to tumor necrosis factor alpha prevent increases in cell replication in liver due to the potent peroxisome proliferator, WY-14,643.
Neoplasms
Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line.
Neoplasms
Antiestrogen stimulated human endometrial cancer growth: laboratory and clinical considerations.
Neoplasms
Antioxidant and antiproliferative activities of methanolic extract from a neglected agricultural product: corn cobs.
Neoplasms
Antiproliferative effects of interferon alpha on human pancreatic carcinoma cell lines are associated with differential regulation of protein kinase C isoenzymes.
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Antisense expression of protein kinase C alpha inhibits the growth and tumorigenicity of human glioblastoma cells.
Neoplasms
Antisense inhibition of protein kinase Calpha reverses the transformed phenotype in human lung carcinoma cells.
Neoplasms
Antisense Oligodeoxynucleotide Technology: Potential Use for the Treatment of Malignant Brain Tumors.
Neoplasms
Antisense strategies targeting protein kinase C: preclinical and clinical development.
Neoplasms
Antitumor activity of a PKC-alpha antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted into nude mice.
Neoplasms
Antitumor activity of the new selective protein kinase C inhibitor 4'-N-benzoyl staurosporine on murine and human tumor models.
Neoplasms
Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1).
Neoplasms
Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.
Neoplasms
Antitumor and normal cell protective effect of PKC412 in the athymic mouse model of ovarian cancer.
Neoplasms
aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6.
Neoplasms
aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia.
Neoplasms
Apoptin interacts with and regulates the activity of protein kinase C beta in cancer cells.
Neoplasms
Apoptosis caused by chemotherapeutic inhibition of nuclear factor-kappaB activation.
Neoplasms
Apoptosis-modulating agents in combination with radiotherapy-current status and outlook.
Neoplasms
Appearance of depolarization- and maitotoxin-induced [Ca2+]i elevation in single LAN-1 human neuroblastoma cells on exposure to retinoic acid.
Neoplasms
Application of phorbol ester to mouse skin causes a rapid and sustained loss of protein kinase C.
Neoplasms
Aspirin-induced apoptosis in human gastric cancer epithelial cells: relationship with protein kinase C signaling.
Neoplasms
Assessing delivery of lipopeptides into the cytoplasm of intact cells by a functional assay based on PKC inhibition. I. The Jurkat model.
Neoplasms
Assessment of the metastatic ability of rat hepatoma cells in chick embryos by the polymerase-chain reaction.
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Association of elevated levels of protein kinase C-zeta mRNA and protein with murine B-lymphocytic neoplasia.
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Association of PKC? Expression with Clinicopathological Characteristics of Breast Cancer.
Neoplasms
Astragaloside IV inhibits PMA-induced EPCR shedding through MAPKs and PKC pathway.
Neoplasms
Atrial natriuretic factor inhibits the phosphorylation of protein kinase C in plasma membrane preparations of cultured Leydig tumor cells.
Neoplasms
Attenuation of Sunitinib-induced cardiotoxicity through the A3 adenosine receptor activation.
Neoplasms
Atypical PKCs activate Vimentin to facilitate prostate cancer cell motility and invasion.
Neoplasms
Atypical Protein Kinase C ?/? Expression Is Associated with Malignancy of Oral Squamous Cell Carcinoma.
Neoplasms
Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling.
Neoplasms
Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells.
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Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer.
Neoplasms
Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.
Neoplasms
Atypical protein kinase C zeta as a target for chemosensitization of tumor cells.
Neoplasms
Atypical protein kinase C zeta exhibits a proapoptotic function in ovarian cancer.
Neoplasms
Atypical protein kinase C zeta: potential player in cell survival and cell migration of ovarian cancer.
Neoplasms
Atypical protein kinase C-zeta modulates clonogenicity, motility, and secretion of proteolytic enzymes in murine mammary cells.
Neoplasms
Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis.
Neoplasms
Augmentation of cytotoxic effect of tumor necrosis factor on human immunodeficiency virus-infected cells by staurosporine, a potent protein kinase C inhibitor.
Neoplasms
Augmentation of TNF cytotoxicity by protein kinase C inhibitors: role of arachidonic acid and manganese superoxide dismutase.
Neoplasms
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts.
Neoplasms
Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity.
Neoplasms
B cell activation. IV. Induction of cell membrane depolarization and hyper-I-A expression by phorbol diesters suggests a role for protein kinase C in murine B lymphocyte activation.
Neoplasms
B16 mouse melanoma cells selected for resistance to cyclic AMP-mediated growth inhibition are cross-resistant to retinoic acid-induced growth inhibition.
Neoplasms
Baicalein inhibits the migration and invasive properties of human hepatoma cells.
Neoplasms
Baicalin Inhibits Human Cervical Cancer Cells by Suppressing Protein Kinase C/Signal Transducer and Activator of Transcription (PKC/STAT3) Signaling Pathway.
Neoplasms
Bcl-10 protein highly correlates with the expression of phosphorylated p65 NF-kappaB in peripheral T-cell lymphomas and is associated with clinical outcome.
Neoplasms
Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter.
Neoplasms
Benzoyl peroxide activation of protein kinase C activity in epidermal cell membranes.
Neoplasms
Beta-adrenergic stimulation of anterior pituitary cyclic AMP is enhanced by tumor promoters.
Neoplasms
Bile acids, non-phorbol-ester-type tumor promoters, stimulate the phosphorylation of protein kinase C substrates in human platelets and colon cell line HT29.
Neoplasms
Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure-activity study on simplified analogs of the receptor-recognition domain.
Neoplasms
Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin.
Neoplasms
Biosynthesis and posttranslational modifications of protein kinase C in human breast cancer cells.
Neoplasms
Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription.
Neoplasms
Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton.
Neoplasms
Both type I and type II interferons down-regulate human tumor necrosis factor receptors in human hepatocellular carcinoma cell line Hep G2. Role of protein kinase C.
Neoplasms
Breast cancer cell invasiveness: correlation with protein kinase C activity and differential regulation by phorbol ester in estrogen receptor-positive and -negative cells.
Neoplasms
Bryostatin 1 enhances lymphokine activated killer sensitivity and modulates the beta 1 integrin profile of cultured human tumor cells.
Neoplasms
Bryostatin 1 inhibits phorbol ester-induced apoptosis in prostate cancer cells by differentially modulating protein kinase C (PKC) delta translocation and preventing PKCdelta-mediated release of tumor necrosis factor-alpha.
Neoplasms
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin.
Neoplasms
Bryostatin 1-induced hairy cell features on chronic lymphocytic leukemia cells in vitro.
Neoplasms
Bryostatin-1 and IFN-gamma synergize for the expression of the inducible nitric oxide synthase gene and for nitric oxide production in murine macrophages.
Neoplasms
Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation.
Neoplasms
Building Bridges toward Invasion: Tumor Promoter Treatment Induces a Novel Protein Kinase C-Dependent Phenotype in MCF10A Mammary Cell Acini.
Neoplasms
c-fos promoter insensitivity to phorbol ester and possible role of protein kinase C in androgen-independent cancer cells.
Neoplasms
Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun, and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species.
Neoplasms
Calcium and protein kinase C regulation of the glucocorticoid receptor in mouse corticotrope tumor cells.
Neoplasms
Calcium-dependent photodynamic action of di- and tetrasulphonated aluminium phthalocyanine on normal and tumour-derived rat pancreatic exocrine cells.
Neoplasms
Calcium-dependent protein kinase-C activity in human adrenocortical neoplasms, hyperplastic adrenals, and normal adrenocortical tissue.
Neoplasms
Calphostin C induces tyrosine dephosphorylation/inactivation of protein kinase FA/GSK-3 alpha in a pathway independent of tumor promoter phorbol ester-mediated down-regulation of protein kinase C.
Neoplasms
Calphostin C triggers calcium-dependent apoptosis in human acute lymphoblastic leukemia cells.
Neoplasms
Can tumour cell drug resistance be reversed by essential fatty acids and their metabolites?
Neoplasms
Cancer-Associated Protein Kinase C Mutations Reveal Kinase's Role as Tumor Suppressor.
Neoplasms
Cancer-preventive selenocompounds induce a specific redox modification of cysteine-rich regions in Ca(2+)-dependent isoenzymes of protein kinase C.
Neoplasms
Carnitine sensitizes TRAIL-resistant cancer cells to TRAIL-induced apoptotic cell death through the up-regulation of Bax.
Neoplasms
CD44 stimulation induces integrin-mediated adhesion of colon cancer cell lines to endothelial cells by up-regulation of integrins and c-Met and activation of integrins.
Neoplasms
CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells.
Neoplasms
Cell Death Signaling Pathway Induced by Cholix Toxin, a Cytotoxin and eEF2 ADP-Ribosyltransferase Produced by Vibrio cholerae.
Neoplasms
Cell genetic evidence of correlation of intracellular translocation of protein kinase C (PKC) and PKC-mediated phosphorylation of 80-kDa protein with mitogenic action of tumor promoters.
Neoplasms
Cell membrane associated protein kinase C as receptor of diterpene ester co-carcinogens of the tumor promoter type and the phenotypic expression of tumors.
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Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation.
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Cell-specific bifunctional role of Jun oncogene family members on glucocorticoid receptor-dependent transcription.
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Cellular protein kinase C isozyme regulation by exogenously delivered physiological disulfides--implications of oxidative protein kinase C regulation to cancer prevention.
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Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis.
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Ceramide mediates inhibition of the renal epithelial sodium channel by tumor necrosis factor-alpha through protein kinase C.
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Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis.
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Changes in diacylglycerol and membrane associated protein kinase C activity reflect the growth status of xenografted human mammary carcinoma treated with 8-Cl-cAMP.
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Changes in glycosaminoglycan sulfation and protein kinase C subcellular distribution during differentiation of the human colon tumor cell line Caco-2.
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Changes in protein kinase C alpha, delta and in nuclear beta isoform expression in tumour and lung metastatic nodules induced by diethylnitrosamine in the rat.
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Chaperoning to the metabolic party: The emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes.
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Characteristics of KIT-negative gastrointestinal stromal tumours and diagnostic utility of protein kinase C theta immunostaining.
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Characterization and modulation of transitional cell carcinoma cell lines with acquired multidrug resistance.
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Characterization of p21Ras-mediated apoptosis induced by protein kinase C inhibition and application to human tumor cell lines.
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Characterization of protein tyrosine kinase activity in murine Leydig tumor cells.
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Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum.
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Characterization of the activation of Na+/H+ exchange in lymphocytes by phorbol esters: change in cytoplasmic pH dependence of the antiport.
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Characterization of the hydroperoxide response observed in mouse skin treated with tumor promoters in vivo.
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Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein.
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Chelerythrine induces apoptosis via ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human renal cell carcinoma.
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Chemosensitization of cancer cells by the staurosporine derivative CGP 41251 in association with decreased P-glycoprotein phosphorylation.
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Cholecystokinin-stimulated protein kinase C-delta kinase activation, tyrosine phosphorylation, and translocation are mediated by Src tyrosine kinases in pancreatic acinar cells.
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Cholera toxin discriminates between murine T lymphocyte proliferation stimulated by activators of protein kinase C and proliferation stimulated by IL-2. Possible role for intracellular cAMP.
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Cholesterol sulfate, a second messenger for the eta isoform of protein kinase C, inhibits promotional phase in mouse skin carcinogenesis.
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Chronic but not acute conjugated linoleic acid treatment inhibits deoxycholic acid-induced protein kinase C and nuclear factor-kappaB activation in human colorectal cancer cells.
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Chronic exposure of LLC-PK1 epithelia to the phorbol ester TPA produces polyp-like foci with leaky tight junctions and altered protein kinase C-alpha expression and localization.
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Circulating Tumor DNA Reflects Uveal Melanoma Responses to Protein Kinase C Inhibition.
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Circumvention of multidrug-resistance in murine fibrosarcoma and colon-carcinoma cells by treatment with the alpha-adrenoceptor antagonist furobenzazepine.
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Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain.
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Clarification of the binding mode of teleocidin and benzolactams to the Cys2 domain of protein kinase Cdelta by synthesis of hydrophobically modified, teleocidin-mimicking benzolactams and computational docking simulation.
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Clinical significance of atypical protein kinase C (PKC? and PKC?) and its relationship with yes-associated protein in lung adenocarcinoma.
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Clinical Significance of PRKCI Gene Expression in Cancerous Tissue in Patients With Gastric Cancer.
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Clinicopathological and immunohistochemical features of gastointestinal stromal tumors.
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Cloning and characterisation of the Hint homologue of the thermophile Thermus thermophilus.
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Cloning and real-time PCR testing of 14 potential biomarkers in Eisenia fetida following cadmium exposure.
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Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells.
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Cobra venom cardiotoxin (cytotoxin) isoforms and neurotoxin: comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and modes of enzyme inhibition.
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Coix Seed Extract, a Commonly Used Treatment for Cancer in China, Inhibits NFkappaB and Protein Kinase C Signaling.
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Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes.
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Colony size, cell density and nature of the tumor promoter are critical variables in expression of a transformed phenotype (focus formation) in co-cultures of UV-TDTx and C3H10T1/2 cells.
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Colorectal laterally spreading tumors show characteristic expression of cell polarity factors, including atypical protein kinase C ?/?, E-cadherin, ?-catenin and basement membrane component.
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Combination of endostatin and a protein kinase Calpha DNA enzyme improves the survival of rats with malignant glioma.
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Combination treatments with the PKC inhibitor, enzastaurin, enhance the cytotoxicity of the anti-mesothelin immunotoxin, SS1P.
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Combined antitumor activity of 7-hydroxystaurosporine (UCN-01) and tamoxifen against human breast carcinoma in vitro and in vivo.
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Combined culture experiment of mouse bone marrow mesenchymal stem cells and bioceramic scaffolds.
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Comparative-studies on the anti-invasive effects of retinoic Acid and staurosporine.
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Comparison of 12-O-tetradecanoylphorbol-13-acetate and teleocidin for induction of epidermal hyperplasia, activation of epidermal PKC isozymes and skin tumor promotion in SENCAR and C57BL/6 mice.
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Comparison of different tumour promoters and bryostatin 1 on protein kinase C activation and down-regulation in rat renal mesangial cells.
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Comparison of epidermal protein kinase C activity, ornithine decarboxylase induction and DNA synthesis stimulated by TPA or dioctanoylglycerol in mouse strains with differing susceptibility to TPA-induced tumor promotion.
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Comparison of octahydromezerein and mezerein as protein kinase C activators and as mouse skin tumor promoters.
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Comparison of some biochemical properties of epidermis in tumor promotion-susceptible and -resistant strains of mice.
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Comparison of the specificity of interaction of cellular and viral zinc-binding domains with 2-mercaptobenzamide thioesters.
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Competence growth factors can cause modification in higher-order chromatin structure in mouse embryo 3T3 fibroblasts.
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Computer-assisted molecular modeling of tumor promoters: rationale for the activity of phorbol esters, teleocidin B, and aplysiatoxin.
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Continuous phosphorylation of both the 47 and the 49 kDa proteins occurs during superoxide production by neutrophils.
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Continuous synthesis of two protein-kinase-C-related proteins after down-regulation by phorbol esters.
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Contrasting effects of the protein kinase C inhibitor, staurosporine, on cytokine and phorbol ester stimulation of fructose 2,6-bisphosphate and prostaglandin E production by fibroblasts in vitro. Comparative studies using interleukin-1 alpha, tumour necrosis factor alpha, transforming growth factor beta, interferon-gamma and 12-O-tetradecanoylphorbol 13-acetate.
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Conventional protein kinase C and atypical protein kinase Czeta differentially regulate macrophage production of tumour necrosis factor-alpha and interleukin-10.
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Conversion of high grade lymphoma tumor cell line to intermediate grade with TPA and bryostatin 1 as determined by polypeptide analysis on 2D gel electrophoresis.
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Cooperative inhibitory effect of n,n,n-trimethylsphingosine and sphingosine-1-phosphate, co-incorporated in liposomes, on b16 melanoma cell metastasis - cell-membrane signaling as a target in cancer-therapy .4.
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Cordycepin stimulated steroidogenesis in MA-10 mouse Leydig tumor cells through the protein kinase C Pathway.
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Correlation of protein kinase C activity and its subcellular distrubution with multidrug resistance in KVB200 cells.
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Correlations of mRNA expression and in vitro chemosensitivity to enzastaurin in freshly explanted human tumor cells.
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Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells.
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cPLA2? reversibly regulates different subsets of cancer stem cells transformation in cervical cancer.
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Cremophor EL inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced protein phosphorylation in human myeloblastic leukemia ML-1 cells.
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Crosstalk of protein kinase C ? with Smad2/3 promotes tumor cell proliferation in prostate cancer cells by enhancing aerobic glycolysis.
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Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester.
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Csa-19, a radiation-responsive human gene, identified by an unbiased two-gel cDNA library screening method in human cancer cells.
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CUB-domain-containing protein 1 overexpression in solid cancers promotes cancer cell growth by activating Src family kinases.
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Current approaches to the management of diabetic retinopathy and diabetic macular oedema.
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Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors.
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Cyclic AMP and calcium in mouse mammary tumour virus expression: effects and post-transcriptional site of action.
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Cyclosporin A inhibits proteolytic cleavage and degradation of membrane-bound protein kinase C in hepatocytes after stimulation by phorbol ester.
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Cytokine-induced production of macrophage inflammatory protein-1alpha (MIP-1alpha) in cultured human astrocytes.
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Cytoprotective effects of N,N,N-trimethylsphingosine during ischemia- reperfusion injury are lost in the setting of obesity and diabetes.
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Cytosolic-nuclear tumor promoter-specific binding protein: association with the 90 kDa heat shock protein and translocation into nuclei by treatment with 12-O-tetradecanoylphorbol 13-acetate.
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Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progression.
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Decreased levels of protein kinase C enzyme activity and protein kinase C mRNA in primary colon tumors.
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Decreased PKC-alpha expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells.
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Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation.
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Deficiency of protein kinase Calpha in mice results in impairment of epidermal hyperplasia and enhancement of tumor formation in two-stage skin carcinogenesis.
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Deletion of the C-26 Methyl Substituent from the Bryostatin Analogue Merle 23 has Negligible Impact on Its Biological Profile or Potency.
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Demonstration of protein kinase C activity in crustacean Y-organs, and partial definition of its role in regulation of ecdysteroidogenesis.
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Demyelination induced by protein kinase C-activating tumor promoters in aggregating brain cell cultures.
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Depletion of tumour glutathione in vivo by buthionine sulphoximine: modulation by the rate of cellular proliferation and inhibition of cancer growth.
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Design and physicochemical properties of new fluorescent ligands of protein kinase C isozymes focused on CH/pi interaction.
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Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta.
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Design of polymeric carriers for cancer-specific gene targeting: utilization of abnormal protein kinase Calpha activation in cancer cells.
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Design, Synthesis, and Biological Activity of Isophthalic Acid Derivatives Targeted to the C1 Domain of Protein Kinase C.
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Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation.
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Development and validation of a drug activity biomarker that shows target inhibition in cancer patients receiving enzastaurin, a novel protein kinase C-beta inhibitor.
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Development of a microscopy-based assay for protein kinase Czeta activation in human breast cancer cells.
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Development of diacyltetrol lipids as activators for the C1 domain of protein kinase C.
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Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor.
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Dietary copper affects azoxymethane-induced intestinal tumor formation and protein kinase C isozyme protein and mRNA expression in colon of rats.
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Diets enriched with cereal brans or inulin modulate protein kinase C activity and isozyme expression in rat colonic mucosa.
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Different cascades in the signaling pathway of two vascular endothelial growth factor (VEGF) receptors for the VEGF-mediated murine hepatocellular carcinoma development.
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Different expression patterns of calpain isozymes 1 and 2 (CAPN1 and 2) in squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) of human skin.
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Different expressions of protein kinase C-alpha, betaI and betaII in glomeruli of diabetic nephropathy patients.
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Different susceptibility of lung cell lines to inhibitors of tumor promotion and inducers of differentiation.
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Differential activation of the 21-base-pair enhancer element of human T-cell leukemia virus type I by its own trans-activator and cyclic AMP.
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Differential down-regulation of epidermal protein kinase C by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol: association with epidermal hyperplasia and tumor promotion.
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Differential effect on inositol-phospholipid hydrolysis, cytosolic-free Ca2+ concentration, protein kinase C activity and protein phosphorylation of 1-oleoyl-2-acetyl-sn-glycerol growth-stimulated ascites tumor cells.
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Differential effects of 12-O-tetradecanoyl-13-phorbol acetate (TPA) on growth, migration and invasion of a human glioma cell line.
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Differential effects of tumor necrosis factor-alpha on protein kinase C isoforms alpha and delta mediate inhibition of insulin receptor signaling.
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Differential expression of protein kinase C and cAMP-dependent protein kinase in normal human melanocytes and malignant melanomas.
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Differential expression of protein kinase C isoenzymes related to high nitric oxide synthase activity in a T lymphoma cell line.
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Differential expression of protein kinase C isozyme messenger RNAs in dunning R-3327 rat prostatic tumors.
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Differential expression of TRAP Isoenzyme in B-CLL Cells Treated with Different Inducers.
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Differential in vivo modifications of the HMGI(Y) nonhistone chromatin proteins modulate nucleosome and DNA interactions.
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Differential induction of 12-O-tetradecanoylphorbol-13-acetate sequence gene expression in murine melanocytes and melanoma cells.
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Differential inhibition by staurosporine of phorbol ester, bryostatin and okadaic acid effects on mouse skin.
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Differential inhibition by staurosporine, a potent protein kinase C inhibitor, of 12-O-tetradecanoylphorbol-13-acetate-caused skin tumor promotion, epidermal ornithine decarboxylase induction, hyperplasia and inflammation.
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Differential inhibition of epidermal growth factor binding by photoactivated psoralens and the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate in cells overexpressing protein kinase C.
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Differential non-redox inhibitory effects of glutathione against protein kinase C isozyme family members.
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Differential p53-dependent mechanism of radiosensitization in vitro and in vivo by the protein kinase C-specific inhibitor PKC412.
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Differential pathways of insulin action upon the hepatitis B surface antigen gene expression and cell proliferation in human hepatoma cells.
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Differential protein kinase C ligand regulation detected in vivo by a phenotypic yeast assay.
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Differential radio-adaptive responses in BALB/c and C57BL/6 mice: pivotal role of calcium and nitric oxide signalling.
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Differential Regulation of Gene Expression by Protein Kinase C Isozymes as Determined by Genome-wide Expression Analysis.
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Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes.
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Differential regulation of phosphatidylcholine biosynthesis by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol in NG108-15 neuroblastoma x glioma hybrid cells.
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Differential regulation of phospholipase A2 in human leukemia cells by the etherphospholipid analogue hexadecylphosphocholine.
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Differential secretion of cathepsins B and L from normal and tumor human lung cells stimulated by 12(S)-hydroxy-eicosatetraenoic acid.
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Differential sensitivity of breast cancer cells to tumor necrosis factor-alpha: involvement of protein kinase C.
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Differential subcellular expression of protein kinase C betaII in breast cancer: correlation with breast cancer subtypes.
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Differential tumor biology effects of double-initiation in a mouse skin chemical carcinogenesis model comparing wild type versus protein kinase Cepsilon overexpression mice.
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Differentiation of human monocytes to monocyte-derived macrophages is associated with increased lipoprotein lipase-induced tumor necrosis factor-alpha expression and production: a process involving cell surface proteoglycans and protein kinase C.
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Differing roles of protein kinase C on the antiproliferative effects of tumor necrosis factor alpha and beta on LoVo cells.
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Differing roles of protein kinase C on the signal transduction of tumour necrosis factor-alpha and -beta on PANC-1 cells: in vitro autoradiographic investigation.
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Diradylglycerol synergizes with an anionic amphiphile to activate superoxide generation and phosphorylation of p47phox in a cell-free system from human neutrophils.
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Direct interaction of all-trans-retinoic acid with protein kinase C (PKC). Implications for PKC signaling and cancer therapy.
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Discovery of a small-molecule protein kinase C?-selective activator with promising application in colon cancer therapy.
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Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy.
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Disparity in expression of protein kinase C alpha in human glioma versus glioma-derived primary cell lines: therapeutic implications.
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Disruption of protein kinase Ceta results in impairment of wound healing and enhancement of tumor formation in mouse skin carcinogenesis.
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Dissecting the 17?-estradiol pathways necessary for neuroglobin anti-apoptotic activity in breast cancer.
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Dissociation between protein kinase C content and biological responsiveness to phorbol esters in tumor promoter-sensitive (MCF-7) and resistant (RPh-4) cells.
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Distinct patterns of phorbol ester-induced downregulation of protein kinase C activity in adriamycin-selected multidrug resistant and parental murine fibrosarcoma cells.
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Distinct signaling mediates chloride secretion induced by tumor promoter bile-salts and phorbol esters in human colonic cells.
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Distinctive requirement of PKC? in the control of Rho GTPases in epithelial and mesenchymally transformed lung cancer cells.
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Distribution and stimulation by gastrin-releasing peptide of protein kinase C subfamilies in insulin-secreting cells.
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DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours.
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Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.
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Down-regulation of particulate protein kinase Cepsilon and up-regulation of nuclear activator protein-1 DNA binding in liver following in vivo exposure of B6C3F1 male mice to heptachlor epoxide.
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Down-regulation of PKCzeta expression inhibits chemotaxis signal transduction in human lung cancer cells.
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Down-regulation of protein kinase C activity in 1,2-dimethylhydrazine-induced rat colonic tumors.
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Down-regulation of protein kinase Ceta by antisense oligonucleotides sensitises A549 lung cancer cells to vincristine and paclitaxel.
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Downregulation of BDNF Expression by PKC and by TNF-? in Human Endothelial Cells.
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Downregulation of tumor necrosis factor (TNF) sensitivity via modulation of TNF binding capacity by protein kinase C activators.
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Downregulation of tumor necrosis factor receptors of macrophages by interferons and interleukin-1. Role of protein kinase C activation.
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Dual Actin-bundling and Protein Kinase C-binding Activities of Fascin Regulate Carcinoma Cell Migration Downstream of Rac and Contribute to Metastasis.
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Dual effects of staurosporine on arachidonic acid metabolism in rat peritoneal macrophages.
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Dz13 induces a cytotoxic stress response with upregulation of E2F1 in tumor cells metastasizing to or from bone.
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E-selectin gene expression is induced synergistically with the coexistence of activated classic protein kinase C and signals elicited by interleukin-1beta but not tumor necrosis factor-alpha.
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Early effects of TPA on protein kinase activity in murine thymocytes. Reduction of protein kinase C activity in the cytosol and increase of Ca2+ and phospholipid-independent kinase activity in the particulate fractions.
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Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice.
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Early events of fusion between Epstein Barr virus and human lymphoblastoid cells (Raji) detected by R18 fluorescence dequenching measurements.
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Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation.
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Ectopic alphaIIbbeta3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells.
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Ectopic expression of a mutant form of PKCalpha originally found in human tumors: aberrant subcellular translocation and effects on growth control.
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Ectopic expression of Par-4 leads to induction of apoptosis in CNS tumor cell lines.
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Ectopic expression of platelet integrin alphaIIb beta3 in tumor cells from various species and histological origin.
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Ectopic Expression of Protein Kinase C-? Sensitizes Head and Neck Squamous Cell Carcinoma to Diterpene Esters.
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Effect of ?-linolenic acid-rich diacylglycerol oil on protein kinase C activation in the rat digestive tract and lingual mucosa.
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Effect of aging on CD11b and CD69 surface expression by vesicular insertion in human polymorphonuclear leucocytes.
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Effect of benzoyl peroxide on protein kinase C in cultured human epidermal keratinocytes.
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Effect of flavonoids on tumor promoter-induced basophil histamine release and protein kinase C.
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Effect of hyperthermia and protein kinase C inhibitors on DNA synthesis and cell proliferation on Ehrlich ascites tumour cells in vitro.
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Effect of MUC1/?-catenin interaction on the tumorigenic capacity of pancreatic CD133(+) cells.
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Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion.
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Effect of phorbol esters on contractile state and calcium flux in cultured chick heart cells.
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Effect of phorbol myristate acetate on alpha 1-adrenergic action in cells expressing recombinant alpha 1-adrenoceptor subtypes.
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Effect of PMA on the integrity of the membrane skeleton and morphology of epithelial MDCK cells is dependent on the activity of amiloride-sensitive ion transporters and membrane potential.
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Effect of Prenatal Waterpipe Tobacco Smoke Exposure on Cardiac Biomarkers in Adult Offspring Rats.
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Effect of protein kinase C activating tumor promoters on metastases formation by fibrosarcoma cells.
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Effect of protein kinase C activators on the phosphorylation and the surface expression of the CDw50 leukocyte antigen.
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Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.
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Effect of staurosporine on N-glycosylation and cell adhesion to fibronectin of SW480 human colorectal adenocarcinoma cells.
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Effect of the dihydropyridine dexniguldipine on the epidermal growth factor-stimulated proliferation of human lung cancer cell lines.
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Effect of the protein kinase inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 and N-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 on Lewis lung carcinoma tumor progression.
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Effect of the tumor promoter phorbol 12-myristate 13-acetate (PMA) on proliferation of young and senescent WI-38 human diploid fibroblasts.
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Effect of tumor necrosis factor-alpha on insulin signal transduction in rat adipocytes: relation to PKCbeta and zeta translocation.
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Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells.
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Effects of a flaxseed mixture and plant oils rich in alpha-linolenic acid on the adenoma formation in multiple intestinal neoplasia (Min) mice.
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Effects of azidothymidine on protein kinase C activity and expression in erythroleukemic cell K562 and acute lymphoblastic leukemia cell HSB-2.
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Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[beta-D-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells.
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Effects of lyngbyatoxin A from the blue-green alga Lyngbya majuscula on rabbit aorta contractions.
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Effects of ortho substituent groups of protocatechualdehyde derivatives on binding to the c1 domain of novel protein kinase C.
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Effects of phorbol ester on spontaneous transmitter release at frog neuromuscular junction.
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Effects of pituitary adenylate cyclase-activating polypeptide on hormone secretion by human pituitary adenomas in vitro.
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Effects of pretreatment with protein kinase C activators on macrophage activation for tumor cytotoxicity, secretion of tumor necrosis factor, and its mRNA expression.
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Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells.
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Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation.
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Effects of Ro 31-8220 on lipopolysaccharides-induced hepatotoxicity and release of tumor necrosis factor from rat Kupffer cells.
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Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities.
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Effects of the putatively oncogenic protein kinase Calpha D294G mutation on enzymatic activity and cell growth and its occurrence in human thyroid neoplasias.
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Effects of the selective bisindolylmaleimide protein kinase C inhibitor GF 109203X on P-glycoprotein-mediated multidrug resistance.
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Effects of the tumor promoter, phorbol 12-myristate, 13-acetate, on the epidermal adenylate cyclase system: evidence for adenylate cyclase-regulation by protein kinase C.
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Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism.
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Effects of transforming growth factor-beta 1 and phorbol ester on PAI-1 and PA genes in human lung cells.
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Effects of tumor promoters (mezerein, teleocidin and palytoxin) on growth hormone secretion from rat anterior pituitary cells cultured in monolayer.
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Effects of tumour necrosis factor-alpha and inhibition of protein kinase C on glucose uptake in L6 myoblasts.
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Effects of ultraviolet-B and PUVA on ornithine decarboxylase activity, DNA synthesis, and protein kinase C activity in mouse skin.
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Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas.
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Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context.
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Efficient priming of protein antigen-specific human CD4(+) T cells by monocyte-derived dendritic cells.
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EGFR inhibitors enhanced the susceptibility to NK cell-mediated lysis of lung cancer cells.
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Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure.
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Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis.
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Elevation of PRKCDBP, a novel transcriptional target of TNF-?, and its downregulation by infliximab in patients with ulcerative colitis.
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Ellagic acid inhibits PKC signaling by improving antioxidant defense system in murine T cell lymphoma.
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Elucidation of stannin function using microarray analysis: implications for cell cycle control.
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Emodin attenuates A23187-induced mast cell degranulation and tumor necrosis factor-? secretion through protein kinase C and I?B kinase 2 signaling.
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Endometrial cancer cell survival and apoptosis is regulated by protein kinase C alpha and delta.
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Engaged urokinase receptors enhance tumor breast cell migration and invasion by upregulating alpha(v)beta5 vitronectin receptor cell surface expression.
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Enhanced induction of epidermal ornithine decarboxylase activity in C57BL/6 compared to DBA/2 mice by protein kinase C-activating skin tumor promoters: relevance to genetically mediated differences in promotion susceptibility.
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Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro.
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Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
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Enhancement of antiproliferative effect of cis-diamminedichloroplatinum(II) by clomiphene and tamoxifen in human ovarian cancer cells.
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Enhancement of HLA class II-restricted CD4+ T cell recognition of human melanoma cells following treatment with bryostatin-1.
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Enhancement of NK cell-mediated lysis of non-small lung cancer cells by nPKC activator, ingenol 3,20 dibenzoate.
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Enhancement of spermidine/spermine N1-acetyltransferase activity by treatment with lithium chloride in Ehrlich ascites tumor cells.
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Entamoeba histolytica stimulates the unstable transcription of c-fos and tumour necrosis factor-alpha mRNA by protein kinase C signal transduction in macrophages.
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Enzastaurin, a protein kinase Cbeta- selective inhibitor, and its potential application as an anticancer agent in lung cancer.
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Enzastaurin, an inhibitor of PKCbeta, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells.
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Enzastaurin, an oral serine/threonine kinase inhibitor, as second- or third-line therapy of non-small-cell lung cancer.
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Enzymatic rationale and preclinical support for a potent protein kinase C beta inhibitor in cancer therapy.
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Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism.
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EpCAM controls actomyosin contractility and cell adhesion by direct inhibition of PKC.
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Epidermal growth factor and tumor promoters prevent DNA fragmentation by different mechanisms.
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Epidermal growth factor-stimulated DNA synthesis requires an influx of extracellular calcium.
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Epithelial Barrier Properties of the 16HBE14o- Human Bronchial Epithelial Cell Culture Model.
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Epithelial-to-Mesenchymal Transition and Oncogenic Ras Expression in Resistance to the Protein Kinase C{beta} Inhibitor Enzastaurin in Colon Cancer Cells.
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Epithelial-to-Mesenchymal Transition and Resistance to Ingenol 3-Angelate, a Novel Protein Kinase C Modulator, in Colon Cancer Cells.
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Epsilon PKC acts like a marker of progressive malignancy in rat liver, but fails to enhance tumorigenesis in rat hepatoma cells in culture.
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Epstein-Barr virus as a therapeutic target in Hodgkin's disease and nasopharyngeal carcinoma.
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Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation.
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Ets transcription factor binding site is required for positive and TNF alpha-induced negative promoter regulation.
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Evidence against a role of general protein kinase C downregulation in skin tumor promotion.
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Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3.
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Evidence for protein kinase C in bovine adrenocortical membrane preparations using [35S] gamma-thio-ATP as a phosphate donor.
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Evidence for two pathways of protein kinase C induction of 2ar expression: correlation with mitogenesis.
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Ex vivo assays to evaluate the role of protein kinase C in tumor cells of patients with breast cancer.
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Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes.
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Exposure of normal human melanocytes to a tumor promoting phorbol ester reverses growth suppression by transforming growth factor beta.
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Expression analysis of protein kinase C isozymes and multidrug resistance associated genes in ovarian cancer cells.
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Expression in lung tumors and genetic mapping of the novel murine protein kinase C eta.
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Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C delta.
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Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type.
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Expression of multiple isoforms of protein kinase C in normal human colon mucosa and colon tumors and decreased levels of protein kinase C beta and eta mRNAs in the tumors.
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Expression of PKCeta in NIH-3T3 cells promotes production of the pro-inflammatory cytokine interleukin-6.
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Expression of protein kinase C alpha in biopsies and surgical specimens of human hepatocellular carcinoma.
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Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific.
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Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate.
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Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids.
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Expression of the invasive phenotype by MCF-7 human breast cancer cells transfected to overexpress protein kinase C-alpha or the erbB2 proto-oncogene.
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Expression pattern of alpha-protein kinase C in human astrocytomas indicates a role in malignant progression.
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Extracellular signal regulated kinase 5 mediates signals triggered by the novel tumor promoter palytoxin.
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Extranuclear ER? is associated with regression of T47D PKC?-overexpressing, tamoxifen-resistant breast cancer.
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Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters.
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Factors influencing chelator-stable, detergent-extractable, phorbol diester-induced membrane association of protein kinase C. Differences between Ca2+-induced and phorbol ester-stabilized membrane bindings of protein kinase C.
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Failure to activate caspase 3 in phorbol ester-resistant leukemia cells is associated with resistance to apoptotic cell death.
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Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity.
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Fine tuning of protein kinase C (PKC) isoforms in cancer: shortening the distance from the laboratory to the bedside.
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Fish oil may impede tumour angiogenesis and invasiveness by down-regulating protein kinase C and modulating eicosanoid production.
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Five of six protein kinase C isoenzymes present in normal mucosa show reduced protein levels during tumor development in the human colon.
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Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones.
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Fluorescent-responsive synthetic C1b domains of protein kinase C? as reporters of specific high-affinity ligand binding.
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Formulation of Liver-Specific PLGA-DY-635 Nanoparticles Loaded with the Protein Kinase C Inhibitor Bisindolylmaleimide I.
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Free cholesterol induces activation but not translocation of protein kinase C in cultured ascites tumour cells.
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From amplification to gene in thyroid cancer: a high-resolution mapped bacterial-artificial-chromosome resource for cancer chromosome aberrations guides gene discovery after comparative genome hybridization.
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Fumonisin B1-induced apoptosis is associated with delayed inhibition of protein kinase C, nuclear factor-kappaB and tumor necrosis factor alpha in LLC-PK1 cells.
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Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha.
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Functional dissection of nuclear envelope mRNA translocation system: effects of phorbol ester and a monoclonal antibody recognizing cytoskeletal structures.
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Functional Doxorubicin-Loaded Omega-3 Unsaturated Fatty Acids Nanoparticles in Reversing Hepatocellular Carcinoma Multidrug Resistance.
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Functional expression of the macrophage colony-stimulating factor receptor in human THP-1 monocytic leukemia cells.
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FZD1 activates protein kinase C delta-mediated drug-resistance in multidrug-resistant MES-SA/Dx5 cancer cells.
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Gastric stromal tumors in Carney triad are different clinically, pathologically, and behaviorally from sporadic gastric gastrointestinal stromal tumors: findings in 104 cases.
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Gastrin activates nuclear factor kappaB (NFkappaB) through a protein kinase C dependent pathway involving NFkappaB inducing kinase, inhibitor kappaB (IkappaB) kinase, and tumour necrosis factor receptor associated factor 6 (TRAF6) in MKN-28 cells transfected with gastrin receptor.
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Gastrin's trophic effect in the colon: identification of a signaling pathway mediated by protein kinase C.
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Gastrointestinal stromal tumor markers in cutaneous melanomas: relationship to prognostic factors and outcome.
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Gastrointestinal stromal tumours (GISTs) negative for KIT (CD117 antigen) immunoreactivity.
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Gender differences in nitric oxide production by alveolar macrophages in ethanol plus lipopolysaccharide-treated rats.
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Gene expression profile in human prostate LNCaP cancer cells by (--) epigallocatechin-3-gallate.
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Gene trap insertion reveals two open reading frames in the mouse SSeCKS gene: the form predominantly detected in the nervous system is suppressed by the insertion while the other, specific of the testis, remains expressed.
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Generating Conformation-Specific Polyclonal and Monoclonal Anti-Protein Kinase C Antibodies and Anti-Active State Specific PKC Antibodies.
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Genetic variations in the PRKCG gene and osteosarcoma risk in a Chinese population: a case-control study.
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Genetically encoded fluorescent reporters to visualize protein kinase C activation in live cells.
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Genomic organization and chromosomal localization of the mouse protein kinase C alpha gene.
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Genomic Profiling of Metastatic Uveal Melanoma and Clinical Results of a Phase I Study of the Protein Kinase C Inhibitor AEB071.
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GH3B6 pituitary tumor cell proliferation is mediated by PKCalpha and PKCepsilon via ERK 1/2-dependent pathway.
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Global gene expression profiling reveals a suppressed immune response pathway associated with 3q amplification in squamous carcinoma of the lung.
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Global phosphotyrosine proteomics identifies PKC? as a marker of responsiveness to Src inhibition in colorectal cancer.
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GLUT12 expression and regulation in murine small intestine and human Caco-2 cells.
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Glutamate released by Japanese encephalitis virus-infected microglia involves TNF-? signaling and contributes to neuronal death.
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Glycoprotein isolated from Solanum nigrum L. modulates the apoptotic-related signals in 12-O-tetradecanoylphorbol 13-acetate-stimulated MCF-7 cells.
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Gonadotropin release and redistribution of calcium-activated, phospholipid-dependent protein kinase in phorbol-stimulated rat pituitary cells.
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Gonadotropin-releasing hormone initiates multiple signaling pathways in human GH-secreting adenomas.
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Gonadotropin-releasing hormone signaling pathways in an experimental ovarian tumor.
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Growth factors modify the epidermal growth factor receptor through multiple pathways.
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Growth inhibition of human melanoma-derived cells by 12-O-tetradecanoyl phorbol 13-acetate.
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Growth state-dependent regulation of protein kinase C in normal and transformed murine cells.
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H3 Histamine Receptor-Mediated Activation of Protein Kinase C{alpha} Inhibits the Growth of Cholangiocarcinoma In vitro and In vivo.
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H7, an inhibitor of protein kinase C, inhibits tumour cell division in mice bearing ascitic Ehrlich's carcinoma.
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Hepatic tumor-promoting chlorinated hydrocarbons stimulate protein kinase C activity.
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Hepatoma-targeted gene delivery using a tumor cell-specific gene regulation system combined with a human liver cell-specific bionanocapsule.
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Heterogeneity in c-jun gene expression in normal and malignant cells exposed to either ionizing radiation or hydrogen peroxide.
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Heterogeneity in responses of human and rodent respiratory epithelial cells to tumor promoters in culture.
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Heterologous desensitization in neoplastic thyroid cells: influence of the phospholipase C signal transduction system on the thyrotropin-adenylate cyclase signal transduction system.
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Heterologous regulation of the epidermal growth factor receptor by palytoxin, a non-12-O-tetradecanoylphorbol-13-acetate-type tumor promoter.
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High nuclear protein kinase C?II expression is a marker of disease recurrence in oral squamous cell carcinoma.
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High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells.
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High-molecular weight hyaluronan reduced renal PKC activation in genetically diabetic mice.
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Homophilic complex formation of CDCP1 via the extracellular CUB2 domain facilitates SFK activation and promotes cancer cell migration.
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Hormone- and tumor promoter-induced activation or membrane association of protein kinase C in intact cells.
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hsa_circ_0092306 Targeting miR-197-3p Promotes Gastric Cancer Development by Regulating PRKCB in MKN-45 Cells.
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hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells.
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Human antioxidant-response-element-mediated regulation of type 1 NAD(P)H:quinone oxidoreductase gene expression. Effect of sulfhydryl modifying agents.
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Hyaluronic acid uptake by the isolated, perfused rat liver: an index of hepatic sinusoidal endothelial cell function.
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Hybridization studies of cultured human pituitary prl and gh producing adenoma cells: Effects of thyrotropin-releasing hormone, somatostatin, and phorbol ester.
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Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not glutathione deficient cells.
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Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway.
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Hypoxia-induced down-modulation of PKCepsilon promotes trail-mediated apoptosis of tumor cells.
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Identification and characterization of a radiation-inducible glycosylated human early-response gene.
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Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.
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Identification of amiloride-sensitive Na+/H+ exchange in rat NB2 node lymphoma cells. Stimulation by 12-O-tetradecanoyl-phorbol-13-acetate.
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Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells.
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Identification of multiple cis-acting elements mediating the induction of prostaglandin G/H synthase-2 by phorbol ester in murine osteoblastic cells.
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Identification of phosphorylation sites on murine nuclear lamin C by RP-HPLC and microsequencing.
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Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines.
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Imaging the rapid yet transient accumulation of regulatory lipids, lipid kinases, and protein kinases during membrane fusion, at sites of exocytosis of MMP-9 in MCF-7 cells.
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Immortalized mammary epithelial cells overexpressing protein kinase C gamma acquire a malignant phenotype and become tumorigenic in vivo.
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Immunochemical characterization of protein kinase C in rat liver nuclei and subnuclear fractions.
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Immunocytochemical evidence for phorbol ester-induced protein kinase C translocation in HL60 cells.
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Immunohistochemical analysis of advanced human breast carcinomas reveals downregulation of protein kinase C alpha.
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Immunohistochemical demonstration of protein kinase C isozymes in human brain tumors.
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Immunohistochemical determination of protein kinase C expression and proliferative activity in human brain tumors.
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Immunohistochemical evidence for the overexpression of protein kinase C in proliferative diseases of human thyroid.
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Immunohistochemical expression of protein kinase C type III in human pituitary adenomas.
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Immunological quantitation of levels of tissue inhibitor of metalloproteinase-1 in human colon cancer.
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Immunomodulation in patients receiving intravenous Bryostatin 1 in a phase I clinical study: comparison with effects of Bryostatin 1 on lymphocyte function in vitro.
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In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo.
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In vitro and in vivo suppression of growth of rat liver epithelial tumor cells by antisense oligonucleotide against protein kinase C-alpha.
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In-vitro modulation of protein kinase C activity by environmental chemical pollutants.
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Inactive caspase 3 activates Akt in human leukemia cells susceptible or resistant to apoptosis induced by phorbol ester.
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Increase in P-glycoprotein accompanied by activation of protein kinase Calpha and NF-kappaB p65 in the livers of rats with streptozotocin-induced diabetes.
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Increase in protein kinase C activity is associated with human fibroblast growth inhibition.
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Increased diacylglycerol levels inhibit [20-3H]phorbol 12,13-dibutyrate binding and the glucocorticoid-mediated increase in glycerol phosphate phosphate dehydrogenase levels in C6 rat glioma cells.
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Increased expression of ornithine decarboxylase by gamma-ray in mouse epidermal cells: relationship with protein kinase C signaling pathway.
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Increased expression of protein kinase C alpha plays a key role in retinoic acid-induced melanoma differentiation.
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Increased levels of phorbin, c-myc, and ornithine decarboxylase RNAs in human colon cancer.
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Increased phosphorylation of nuclear phosphoproteins in human lung-cancer cells resistant to cis-diamminedichloroplatinum (II).
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Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta.
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Increased protein kinase C delta in mammary tumor cells: relationship to transformtion and metastatic progression.
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Increased tight junction permeability can result from protein kinase C activation/translocation and act as a tumor promotional event in epithelial cancers.
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Independent mechanisms for tumor promoters phenobarbital and 12-O-tetradecanoylphorbol-13-acetate in reduction of epidermal growth factor binding by rat hepatocytes.
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Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes.
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Induction and desensitization of plasminogen activator gene expression by tumor promoters.
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Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and -beta overexpression.
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Induction of angiogenesis by expression of soluble type II transforming growth factor-beta receptor in mouse hepatoma.
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Induction of apoptosis of lung and esophageal cancer cells treated with the combination of histone deacetylase inhibitor (trichostatin A) and protein kinase C inhibitor (calphostin C).
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Induction of cancer cell apoptosis by alpha-tocopheryl succinate: molecular pathways and structural requirements.
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Induction of colon cancer cell death by 7-hydroxystaurosporine (UCN-01) is associated with increased p38 MAPK and decreased Bcl-xL.
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Induction of early growth response-1 gene by interleukin-1 beta and tumor necrosis factor-alpha in normal human bone marrow stromal an osteoblastic cells: regulation by a protein kinase C inhibitor.
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Induction of EL4 cell resistance to syngeneic macrophage-mediated lysis by protein kinase C ligands; effects of cultured TPA-treated target cell and protein phosphorylation.
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Induction of Epstein-Barr virus lytic cycle by tumor-promoting and non-tumor-promoting phorbol esters requires active protein kinase C.
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Induction of intercellular adhesion molecule-1 by tumor necrosis factor-alpha through the 55-kDa receptor is dependent on protein kinase C in human retinal pigment epithelial cells.
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Induction of mitotic catastrophe by PKC inhibition in Nf1-deficient cells.
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Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Calpha antisense oligonucleotide.
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Induction of protein kinase C translocation and cell differentiation in ML-1 human myeloblastic leukemic cells by tumor necrosis factor-alpha, transforming growth factor-beta, or tetradecanoylphorbol acetate.
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Induction of superoxide by 12-O-tetradecanoylphorbol-13-acetate and thapsigargin, a non-phorbol-ester-type tumor promoter, in peritoneal macrophages elicited from SENCAR and B6C3F1 mice: a permissive role for the arachidonic acid cascade in signal transduction.
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Induction of thioredoxin, thioredoxin reductase and glutaredoxin activity in mouse skin by TPA, a calcium ionophore and other tumor promoters.
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Induction of tumor necrosis factor alpha gene expression by lipoprotein lipase requires protein kinase C activation.
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Inductive effect of Porphyromonas gingivalis fimbriae on differentiation of human monocytic tumor cell line U937.
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Inflammatory biomarkers as a part of diagnosis in diabetic peripheral neuropathy.
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Influence of 50 Hz electromagnetic fields in combination with a tumour promoting phorbol ester on protein kinase C and cell cycle in human cells.
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Influence of CO2 pneumoperitoneum on intracellular pH and signal transduction in cancer cells.
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Inhibition by lipoxygenase inhibitors of 7-bromomethylbenz[a]anthracene-caused epidermal ornithine decarboxylase induction and skin tumor promotion in mice.
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Inhibition by phorbol esters and other tumor promoters of the response of the Sertoli cell to FSH: evidence for dual site of action.
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Inhibition by sphingosine of leukemic cell killing by human monocytes activated with interleukin-2: a possible role of protein kinase C.
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Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects.
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Inhibition of angiogenesis in vitro and in ovo with an inhibitor of cellular protein kinases, MDL 27032.
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Inhibition of chemotactic peptide-induced phosphoinositide hydrolysis by phorbol esters through the activation of protein kinase C in differentiated human leukemia (HL-60) cells.
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Inhibition of cytopathic effect of human immunodeficiency virus type-1 by various phorbol derivatives.
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Inhibition of cytotoxic T lymphocyte-mediated lysis and cellular proliferation by isoquinoline sulfonamide protein kinase inhibitors. Evidence for the involvement of protein kinase C in lymphocyte function.
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Inhibition of dimethylsulfoxide-induced differentiation in Friend erythroleukemic cells by diacylglycerols and phospholipase C.
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Inhibition of Ehrlichia risticii infection in murine peritoneal macrophages by gamma interferon, a calcium ionophore, and concanavalin A.
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Inhibition of gap junctional intercellular communication by tumor promoters in connexin43 and connexin32-expressing liver cells: cell specificity and role of protein kinase C.
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Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression.
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Inhibition of human androgen-independent PC-3 and DU-145 prostate cancers by antagonists of bombesin and growth hormone releasing hormone is linked to PKC, MAPK and c-jun intracellular signalling.
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Inhibition of human immunodeficiency virus type 1 replication in vitro by a novel combination of anti-Tat single-chain intrabodies and NF-kappa B antagonists.
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Inhibition of human p53 basal transcription by down-regulation of protein kinase Cdelta.
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Inhibition of mitogen-activated protein kinase kinase does not impair primary activation of human platelets.
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Inhibition of mouse skin tumor promotion by adriamycin and daunomycin in combination with verapamil or palmitoylcarnitine.
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Inhibition of neutrophil migration by a protein kinase inhibitor for the treatment of ischemic brain infarction.
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Inhibition of novel protein kinase C-epsilon augments TRAIL-induced cell death in A549 lung cancer cells.
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Inhibition of phorbol ester-caused induction of ornithine decarboxylase and tumor promotion in mouse skin by staurosporine, a potent inhibitor of protein kinase C.
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Inhibition of PKC-induced COX-2 and IL-8 Expression in Human Breast Cancer Cells by Glucosamine.
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Inhibition of PMA-induced human T cell proliferation by bryostatin is associated with enhanced degradation of conventional protein kinase C (cPKC): Ca2+ signals restore mitogenic activity without abrogating enhanced cPKC degradation.
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Inhibition of Protein Kinase C ?(2) Prevents Tumor Necrosis Factor-?-Induced Apoptosis and Oxidative Stress in Endothelial Cells: The Role of NADPH Oxidase Subunits.
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Inhibition of protein kinase C by antineoplastic agents: implications for drug resistance.
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Inhibition of protein kinase C by the 12-O-tetradecanoylphorbol-13-acetate antagonist glycyrrhetic acid.
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Inhibition of protein kinase C prevents asbestos-induced c-fos and c-jun proto-oncogene expression in mesothelial cells.
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Inhibition of protein kinase Calpha enhances anticancer agent-induced loss of anchorage-independent growth regardless of protection against apoptosis by Bcl-2.
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Inhibition of protein kinase Cbeta by enzastaurin enhances radiation cytotoxicity in pancreatic cancer.
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Inhibition of protein kinase Cbeta prevents foam cell formation by reducing scavenger receptor A expression in human macrophages.
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Inhibition of queuine uptake in diploid human fibroblasts by phorbol-12,13-didecanoate. Requirement for a factor derived from early passage cells.
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Inhibition of ras p21 membrane localization and modulation of protein kinase C isozyme expression during regression of chemical carcinogen-induced murine skin tumors by lovastatin.
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Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.
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Inhibition of the growth of glioblastomas by CGP 41251, an inhibitor of protein kinase C, and by a phorbol ester tumor promoter.
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Inhibition of tumor angiogenesis by targeting endothelial surface ATP synthase with sangivamycin.
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Inhibition of tumor formation from grafted murine papilloma cells by treatment of grafts with staurosporine, an inducer of squamous differentiation.
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Inhibition of tumor promoter 12-O-tetradecanoylphorbol-13-acetate-induced synthesis of epidermal ornithine decarboxylase messenger RNA and diacylglycerol-promoted mouse skin tumor formation by retinoic acid.
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Inhibitory effect of isomorellin on cholangiocarcinoma cells via suppression of NF-?B translocation, the phosphorylated p38 MAPK pathway and MMP-2 and uPA expression.
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Inhibitory effects of radical scavengers on diacylglycerol-promoted transformation in BALB/3T3 cells.
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Inhibitory effects of tetradecanoylphorbol acetate and diacylglycerol on erythropoietin production in human renal carcinoma cell cultures.
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INK4 Family -A promising target for 'gene-regulating chemoprevention' and 'molecular-targeting prevention' of cancer.
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Inositol 1,3,4,5-tetrakisphosphate stimulates the initiation of DNA synthesis in Ca2+-deprived rat liver cells.
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Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation.
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Insulin and platelet-derived growth factor acutely stimulate glucose transport in 3T3-L1 fibroblasts independently of protein kinase C.
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Insulin induction of c-Ki-ras in rat liver and in cultured normal rat hepatocytes.
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Insulin stimulation of glucose metabolism in rat adipocytes: possible implication of protein kinase C.
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Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma.
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Interactive effects of pertussis toxin and the phorbol ester tumour promotor, phorbol dibutyrate, on T-lymphocyte mitogenesis and the expression of phenotypic determinants.
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Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer.
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Interferon-gamma, bacterial lipopolysaccharide, and tumor necrosis factor-alpha induce CD11a mRNA and protein via Na+/H+ exchange and protein kinase C-dependent mechanisms in tissue macrophages.
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Interleukin 1-beta- and tumor necrosis factor-alpha-mediated regulation of ICAM-1 gene expression in astrocytes requires protein kinase C activity.
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Interleukin-8 stimulates the migration of human colonic epithelial cells in vitro.
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Interplay between REST and nucleolin transcription factors: a key mechanism in the overexpression of genes upon increased phosphorylation.
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Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).
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Intracellular activation of protein kinase C and regulation of the surface transferrin receptor by diacylglycerol is a spontaneously reversible process that is associated with rapid formation of phosphatidic acid.
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Intracellular signaling of tumor necrosis factor-alpha in brain microvascular endothelial cells is mediated by a protein tyrosine kinase and protein kinase C-dependent pathway.
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Intrinsic cytotoxicity and chemomodulatory actions of novel phenethylisothiocyanate sphingoid base derivatives in HL-60 human promyelocytic leukemia cells.
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Involvement of PKC-beta in PTH, TNF-alpha, and IL-1 beta effects on IL-6 promoter in osteoblastic cells and on PTH-stimulated bone resorption.
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Involvement of protein kinase C activation in ornithine decarboxylase gene expression in primary culture of newborn mouse epidermal cells and in skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
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Involvement of protein kinase C and cyclic adenosine 3',5'-monophosphate-dependent kinase in steroidogenic acute regulatory protein expression and steroid biosynthesis in Leydig cells.
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Involvement of protein kinase C and protein tyrosine kinase pathways in tumor necrosis factor-alpha-induced clustering of ovarian theca-interstitial cells.
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Involvement of protein kinase C in nerve growth factor- and K-252a-stimulated calcium uptake into PC12 cells.
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Involvement of protein kinase C in regulating tumor necrosis factor alpha-stimulated progesterone production in rat preovulatory follicles in vitro.
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Involvement of protein kinase Cdelta in contact-dependent inhibition of growth in human and murine fibroblasts.
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Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis.
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Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus.
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Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction.
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Isoform-specific activation of protein kinase c in irradiated human fibroblasts and their bystander cells.
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Isoforms of protein kinase C and their distribution in human adrenal cortex and tumors.
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Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.
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J-4: a novel and typical preclinical anticancer drug targeting protein kinase C ?.
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Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C.
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Killing of cancer cells by the photoactivatable protein kinase C inhibitor, calphostin C, involves induction of endoplasmic reticulum stress.
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KIT-Negative Gastrointestinal Stromal Tumor of the Abdominal Soft Tissue: A Clinicopathologic and Genetic Study of 10 Cases.
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Klotho Ameliorates Cellular Inflammation via Suppression of Cytokine Release and Upregulation of miR-29a in the PBMCs of Diagnosed Alzheimer's Disease Patients.
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Labile repressors are involved in the transcriptional control of PDGF-responsive genes.
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Lack of correlation between translocation and biological effects mediated by protein kinase C: an appraisal.
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Lack of effect of a 60 Hz magnetic field on biomarkers of tumor promotion in the skin of SENCAR mice.
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Lack of overt genome reduction in the bryostatin-producing bryozoan symbiont, "Candidatus Endobugula sertula".
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Laminin regulates a tumor cell chemotaxis receptor through the laminin-binding integrin subunit alpha 6.
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Lead Increases Lipopolysaccharide-Induced Liver-Injury Through Tumor Necrosis Factor-alpha Overexpression by Monocytes/Macrophages: Role of Protein Kinase C and P42/44 Mitogen-Activated Protein Kinase.
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Lead induced DNA strand breaks in lymphocytes of exposed workers: role of reactive oxygen species and protein kinase C.
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Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila.
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Linking protein kinase C to the cell cycle: ectopic expression of PKC eta in NIH3T3 cells alters the expression of cyclins and Cdk inhibitors and induces adipogenesis.
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Lipopolysaccharide-stimulated TNF-alpha release from cultured rat Kupffer cells: sequence of intracellular signaling pathways.
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Liposomal N,N,N-trimethylsphingosine (TMS) as an inhibitor of B16 melanoma cell growth and metastasis with reduced toxicity and enhanced drug efficacy compared to free TMS: cell membrane signaling as a target in cancer therapy III.
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Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C.
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Liver tumor promotion: effect of phenobarbital on EGF and protein kinase C signal transduction and transforming growth factor-beta 1 expression.
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LncRNA RP11-19E11 is an E2F1 target required for proliferation and survival of basal breast cancer.
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Localization of aPKC lambda/iota and its interacting protein, Lgl2, is significantly associated with lung adenocarcinoma progression.
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Localization of PKC? in Cell Membranes as a Predictor for Breast Cancer Response to Treatment.
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Localization of protein kinase C alpha isoform expression in the human gastrointestinal tract.
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Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells.
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Long-chain (sphingoid) bases inhibit multistage carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristate 13-acetate.
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Long-wave ultraviolet radiation induces protein kinase C in normal human keratinocytes.
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Loss of mouse epidermal protein kinase C isozyme activities following treatment with phorbol ester and non-phorbol ester tumor promoters.
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Loss of protein kinase C delta gene expression in human squamous cell carcinomas: a laser capture microdissection study.
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Loss of protein kinase Calpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma.
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Malignant glioma sensitivity to radiotherapy, high-dose tamoxifen, and hypericin: corroborating clinical response in vitro: case report.
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MAPK activity is down-regulated in human colon adenocarcinoma: correlation with PKC activity.
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MARCKSL1 promotes the proliferation, migration and invasion of lung adenocarcinoma cells.
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Matrigel invasion by the prostate cancer cell lines, PC3 and DU145, and cathepsin L+B activity.
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Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer.
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Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: potential roles of protein kinase C-alpha, -beta II, and -zeta.
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Mechanism of calcium ionophore A23187-induced priming of bone marrow-derived macrophages for tumor cell killing: relationship to priming by interferon.
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Mechanism of growth inhibition of mammary carcinomas by glucarate and the glucarate: retinoid combination.
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Mechanism of hepatic glycogen synthase inactivation induced by Ca2+-mobilizing hormones. Studies using phospholipase C and phorbol myristate acetate.
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Mechanisms in the chemoprevention of colon cancer: modulation of protein kinase C, tyrosine protein kinase and diacylglycerol kinase activities by 1,4-phenylenebis-(methylene)selenocyanate and impact of low-fat diet.
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Mechanisms involved in ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate, a potent mouse skin tumor promoter and an activator of protein kinase C.
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Mechanisms involved in the down-regulation of TCR zeta chain in tumor versus peripheral blood of oral cancer patients.
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Mechanistic insight on the role of leukotriene receptors in ischemic-reperfusion injury.
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Membrane and cytosolic protein phosphorylation patterns in the early stages of DEN-induced hepatocarcinogenesis in rats fed a high or low protein diet.
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Membrane depolarization induces protein kinase C translocation and voltage operated calcium channel opening in PU5-1.8 cells. Protein kinase C as a negative feedback modulator for calcium signalling.
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Membrane Interaction and Protein Kinase C-C1 Domain Binding Properties of 4-Hydroxy-3-(hydroxymethyl) Phenyl Ester Analogues.
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Membrane phospholipid turnover in signal transduction; protein kinase C and mechanism of action of tumor promoters.
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Membrane protein-lipid hydrogen bonding: evidence from protein kinase C, diglyceride, and tumor promotors.
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Membrane-bound protein kinase C modulates receptor affinity and chemotactic responsiveness of Lewis lung carcinoma sublines to an elastin-derived peptide.
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Membrane-derived second messenger regulates x-ray-mediated tumor necrosis factor alpha gene induction.
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Mesocestoides lineatus: trypsin induced development to adult mediated by Ca2+ and protein kinase C.
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MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis.
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Meta-analysis of oncogenic protein kinase Ciota signaling in lung adenocarcinoma.
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Microfluidic Biopsy Trapping Device for the Real-Time Monitoring of Tumor Microenvironment.
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MicroRNA 15a, inversely correlated to PKC?, is a potential marker to differentiate between benign and malignant renal tumors in biopsy and urine samples.
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miR-24-3p Suppresses Malignant Behavior of Lacrimal Adenoid Cystic Carcinoma by Targeting PRKCH to Regulate p53/p21 Pathway.
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Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic Ras.
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Mitogen-induced, FAK-dependent tyrosine phosphorylation of the SSeCKS scaffolding protein.
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Mitogen-stimulated tyrosine phosphorylation of a 42-kD cellular protein: evidence for a protein kinase-C requirement.
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Mitogenic actions of peroxidase proliferators: involvement of protein kinase C and tumor necrosis factor alpha.
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Modifications of cysteine-rich regions in protein kinase C induced by oxidant tumor promoters and enzyme-specific inhibitors.
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Modulation of cell signaling pathways can enhance or impair glucocorticoid-induced gene expression without altering the state of receptor phosphorylation.
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Modulation of cellular phorbol ester binding and/or protein kinase C activity by human placental fractions.
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Modulation of chemosensitivity in human colon carcinoma cells by downregulating protein kinase C alpha expression.
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Modulation of human CACO-2 intestinal epithelial cell phenotype by protein kinase C inhibitors.
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Modulation of human melanoma cell metastasis and adhesion may involve integrin phosphorylation mediated through protein kinase C.
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Modulation of luteinizing hormone-stimulated inositol phosphate accumulation by phorbol esters in bovine luteal cells.
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Modulation of Pancreatic Tumor Potential by Overexpression of Protein Kinase C ?1.
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Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): key role of quercetin in cancer prevention.
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Modulation of protein kinase C activity and [3H]phorbol 12,13-dibutyrate binding by various tumor promoters in mouse brain cytosol.
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Modulation of protein kinase C activity during inhibition of tumor cell growth by IFN-beta and -gamma.
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Modulation of the human protein kinase C alpha gene promoter by activator protein-2.
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Modulation of tumor necrosis factor-alpha and oxidative stress through protein kinase C and P42/44 mitogen-activated protein kinase in lead increases lipopolysaccharide-induced liver damage in rats.
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Modulation of [3H]dihydropyridine receptors by activation of protein kinase C in chick muscle cells.
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Molecular cloning of gene sequences regulated by tumor promoters and mitogens through protein kinase C.
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Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes.
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Molecular geometries and steric energies of phorbol 10,11-diacetate and 1,2-diacetylglycerol molecules.
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Molecular systems pharmacology: isoelectric focusing signature of protein kinase C? provides an integrated measure of its modulation in response to ligands.
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Molecular targeting of the PKC-beta inhibitor enzastaurin (LY317615) in multiple myeloma involves a coordinated downregulation of MYC and IRF4 expression.
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Motility analysis of pancreatic adenocarcinoma cells reveals a role for the atypical zeta isoform of protein kinase C in cancer cell movement.
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Mouse protein kinase C-delta, the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein.
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MT103 inhibits tumor growth with minimal toxicity in murine model of lung carcinoma via induction of apoptosis.
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Multimodality therapy: radiation and continuous concomitant cis-platinum and PKC inhibition in a cervical carcinoma model.
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Multiple gene expression analysis reveals distinct differences between G2 and G3 stage breast cancers, and correlations of PKC eta with MDR1, MRP and LRP gene expression.
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Multiple signal pathways are involved in the mitogenic effect of 5(S)-HETE in human pancreatic cancer.
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Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.
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Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers.
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Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivo.
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MZF-1/Elk-1/PKC? is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma.
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Na+, K+, Cl- cotransport and its regulation in Ehrlich ascites tumor cells. Ca2+/calmodulin and protein kinase C dependent pathways.
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Nanog expression is negatively regulated by Protein Kinase C activities in human cancer cell lines.
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Neurotransmitters and chemokines regulate tumor cell migration: potential for a new pharmacological approach to inhibit invasion and metastasis development.
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Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate.
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New antiinflammatory compounds that inhibit tumor necrosis factor production: probable interaction with protein kinase C activation.
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New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity.
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New directions in cancer therapy based on aberrant expression of glycosphingolipids: anti-adhesion and ortho-signaling therapy.
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New insights into the regulation of protein kinase C and novel phorbol ester receptors.
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New paradigms in anticancer therapy: targeting multiple signaling pathways with kinase inhibitors.
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NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A, protein kinase C, and Ca(2+)-regulated kinases.
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Nicotine promotes mammary tumor migration via a signaling cascade involving protein kinase C and CDC42.
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Nocardia fractions, NLD and NWSM, induce tumor necrosis factor-alpha secretion in human monocytes: role of protein kinase C.
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Non-invasive detection of fecal protein kinase C betaII and zeta messenger RNA: putative biomarkers for colon cancer.
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Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon.
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Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc.
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Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C.
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NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-? and reactive oxygen species.
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Novel and classical protein kinase C isoforms have different functions in proliferation, survival and differentiation of neuroblastoma cells.
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Novel antitumor effect of estradiol in athymic mice injected with a T47D breast cancer cell line overexpressing protein kinase Calpha.
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Novel roles of the autocrine motility factor/phosphoglucose isomerase in tumor malignancy.
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Novel synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth.
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Nuclear protein kinase substrates in AtT-20 cells: translocation of a 14 kDa phosphoprotein.
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Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex.
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Okadaic acid activates microtubule-associated protein kinase in quiescent fibroblastic cells.
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Okadaic acid induces down-modulation and shedding of tumor necrosis factor receptors. Comparison with another tumor promoter, phorbol ester.
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Okadaic acid stimulates the expression of vascular endothelial growth factor gene.
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Okadaic acid, sphingosine, and phorbol ester reversibly modulate heat induction on protein kinase FA/GSK-3 alpha in A431 cells.
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Okadaic acid-induced hyperphosphorylation of the epidermal growth factor receptor. Comparison with receptor phosphorylation and functions affected by another tumor promoter, 12-O-tetradecanoylphorbol-13-acetate.
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Opposing effects of calcium entry and phorbol esters on fusion of chick muscle cells.
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Opposite and independent actions of cyclic AMP and transforming growth factor beta in the regulation of type 1 plasminogen activator inhibitor expression.
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Opposite effects of interleukin-2 (IL-2) and interferon gamma (IFN gamma) on rat atria contractility.
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Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model.
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Organ-specific activation of activator protein-1 in transgenic mice by 12-o-tetradecanoylphorbol-13-acetate with different administration methods.
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Osteopontin is a potential target gene in mouse mammary cancer chemoprevention by Se-methylselenocysteine.
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Osteopontin mediates dense culture-induced proliferation and adhesion of prostate tumour cells: role of protein kinase C, p38 mitogen-activated protein kinase and calcium.
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Over-expression of insulin-response element binding protein-1 (IRE-BP1) in mouse pancreatic islets increases expression of RACK1 and TCTP: Beta cell markers of high glucose sensitivity.
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Over-expression of protein kinase C delta is associated with a delay in preneoplastic lesion development in diethylnitrosamine-induced rat hepatocarcinogenesis.
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Over-expression of protein kinase C?isoforms (?, ?, ? and ?) in squamous cervical cancer.
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Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model.
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Overexpression of PKC zeta in NIH3T3 cells does not induce cell transformation nor tumorigenicity and does not alter NF kappa B activity.
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Overexpression of PKCalpha is required to impart estradiol inhibition and tamoxifen-resistance in a T47D human breast cancer tumor model.
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Overexpression of PKCepsilon sensitizes LNCaP human prostate cancer cells to induction of apoptosis by bryostatin 1.
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Overexpression of protein kinase C alpha mRNA in human hepatocellular carcinoma: a potential marker of disease prognosis.
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Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples.
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Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression.
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Overexpression of protein kinase C-alpha and -beta isozymes by stromal dendritic cells in basal and squamous cell carcinoma.
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Overexpression of protein kinase C-alpha in MCF-7 breast cancer cells results in differential regulation and expression of alphavbeta3 and alphavbeta5.
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Overexpression of protein kinase C-alpha in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2 and TNF-alpha expression but not tumor promotion.
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Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.
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Overexpression of protein kinase C-delta plays a crucial role in interleukin-6-producing pheochromocytoma presenting with acute inflammatory syndrome: a case report.
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Overexpression of protein kinase C-eta attenuates caspase activation and tumor necrosis factor-alpha-induced cell death.
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Overexpression of protein kinase C-zeta (PKC-zeta) inhibits invasive and metastatic abilities of Dunning R-3327 MAT-LyLu rat prostate cancer cells.
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Oxidative stress mediates CoCl(2)-induced prostate tumour cell adhesion: role of protein kinase C and p38 mitogen-activated protein kinase.
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p21(Waf1/Cip1) and p53 are downstream effectors of protein kinase C delta in tumor suppression and differentiation in human colon cancer cells.
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p62 binding to protein kinase C ? regulates tumor necrosis factor ?-induced apoptotic pathway in endothelial cells.
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Pak-1 expression increases with progression of colorectal carcinomas to metastasis.
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Palmatine alleviates hyperalgesia by inhibiting the expression of calcitonin gene-related peptide in the trigeminal ganglion of rats with chronic constriction injury of the infraorbital nerve.
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Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation.
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Palytoxin: exploiting a novel skin tumor promoter to explore signal transduction and carcinogenesis.
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Paradoxical stimulation and inhibition by protein kinase C modulating agents of lipopolysaccharide evoked production of tumour necrosis factor in human monocytes.
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Parallel changes in amino acid transport and protein kinase C localization in LLC-PK1 cells treated with TPA or diradylglycerols.
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Parallel regulation of parentally imprinted H19 and insulin-like growth factor-II genes in cultured human fetal adrenal cells.
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Patterns of protein kinase C isoenzyme expression in transitional cell carcinoma of bladder. Relation to degree of malignancy.
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PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism.
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Pentoxifylline and other protein kinase C inhibitors down-regulate HIV-LTR NF-kappa B induced gene expression.
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PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.
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Peroxisomal proliferators inhibit acyl CoA synthetase and stimulate protein kinase C in vivo.
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Perturbation of in vitro drug resistance in human lymphatic neoplasms by combinations of putative inhibitors of protein kinase C.
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Pharmacological inhibition of protein kinase C activity could induce apoptosis in gastric cancer cells by differential regulation of apoptosis-related genes.
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Pharmacology of the receptors for the phorbol ester tumor promoters: multiple receptors with different biochemical properties.
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Phase I clinical and pharmacokinetic study of protein kinase C-alpha antisense oligonucleotide ISIS 3521 administered in combination with 5-fluorouracil and leucovorin in patients with advanced cancer.
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Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer.
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Phase I dose escalation and pharmacokinetic study of oral enzastaurin (LY317615) in advanced solid tumors.
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Phase I evaluation of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C-alpha, in patients with advanced cancer.
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Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer.
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Phase I study of an antisense oligonucleotide to protein kinase C-alpha (ISIS 3521/CGP 64128A) in patients with cancer.
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Phase I study of bryostatin 1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia.
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Phase I study of bryostatin 1, a protein kinase C modulator, preceding cisplatin in patients with refractory non-hematologic tumors.
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Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo. The Cancer Research Campaign Phase I Committee.
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Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors.
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Phase II trial of bryostatin-1 in combination with cisplatin in patients with recurrent or persistent epithelial ovarian cancer: a California cancer consortium study.
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Phase II trial of the combination of bryostatin-1 and cisplatin in advanced or recurrent carcinoma of the cervix: a New York Gynecologic Oncology Group study.
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Phorbol 12-myristate 13-acetate inhibits death receptor-mediated apoptosis in Jurkat cells by disrupting recruitment of Fas-associated polypeptide with death domain.
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Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-associated death domain and receptor-interacting protein into the TNF receptor 1 signaling complex: Implication for the regulatory role of protein kinase C.
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Phorbol diester treatment promotes enhanced adenylate cyclase activity in frog erythrocytes.
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Phorbol ester activation of epidermal protein kinase C from tumor promotion sensitive and resistant mouse strains.
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Phorbol ester effects on alpha 1-adrenoceptor binding and phosphatidylinositol metabolism in cultured vascular smooth muscle cells.
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Phorbol ester facilitates 45Ca accumulation and catecholamine secretion by nicotine and excess K+ but not by muscarine in rat adrenal medulla.
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Phorbol ester impairs melanotropin receptor function and stimulates growth of cultured M2R melanoma cells.
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Phorbol ester induced rapid attachment and spreading of melanoma cells and the role of extracellular matrix proteins.
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Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer.
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Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaP(E) cells.
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Phorbol ester tumor promoter regulation of natural antitumor antibody binding depends on protein kinase C and an intact microfilament system.
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Phorbol ester- and Ca2+-dependent phosphorylation of human red cell membrane skeletal proteins.
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Phorbol ester-induced alteration of differentiation and proliferation in human hematopoietic tumor cell lines: relationship to the presence and subcellular distribution of protein kinase C.
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Phorbol ester-induced alteration of protein kinase C catalytic properties occurs at the membrane level and is not reproduced by physiological stimuli.
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Phorbol ester-mediated association of protein kinase C to the nuclear fraction in NIH 3T3 cells.
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Phorbol ester-stimulated NF-kappaB-dependent transcription: roles for isoforms of novel protein kinase C.
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Phorbol esters affect pituitary growth hormone (GH) and prolactin release: the interaction with GH releasing factor, somatostatin and bromocriptine.
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Phorbol esters alter muscarinic receptor binding and inhibit polyphosphoinositide breakdown in human neuroblastoma (SH-SY5Y) cells.
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Phorbol esters inhibit low density lipoprotein processing by cultured human fibroblasts.
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Phorbol esters inhibit the proliferation of MCF-7 cells. Possible implication of protein kinase C.
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Phorbol esters mediate phospholipid-free activation of rat brain protein kinase C.
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Phorbol esters that activate protein kinase C induce long-term changes of membrane excitability and postsynaptic currents in neocortical neurons.
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Phorbol myristate acetate and Bryostatin 1 rescue IFN-gamma inducibility of MHC class II molecules in LS1034 colorectal carcinoma cell line.
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Phorbol myristate acetate induces endocytosis as well as exocytosis and hydroosmosis in toad urinary bladder.
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Phosphatidylinositol 3-kinase/Akt activation by integrin-tumor matrix interaction suppresses Fas-mediated apoptosis in T cells.
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Phospholipase C-induced monocytic differentiation in a human monocytic leukemia cell line THP-1.
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Phospholipase D- and protein kinase C isoenzyme-dependent signal transduction pathways activated by the calcitonin receptor.
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Phospholipid/calcium-dependent protein kinase (protein kinase C) system: a major site of bioregulation.
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Phosphoprotein, protein kinase C, and second-messenger system changes in human multidrug-resistant cancer cells.
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Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples.
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Phosphorylation at a tyrosine residue of lipomodulin in mitogen-stimulated murine thymocytes.
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Phosphorylation is involved in the regulation of the taurine influx via the beta-system in Ehrlich ascites tumor cells.
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Phosphorylation is required for PMA- and cell-cycle-induced degradation of protein kinase Cdelta.
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Phosphorylation of p90 and p52 in response to phorbol-esters in Swiss/3T3 cells overexpressing protein kinase C-alpha.
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Pigment-Synthesizing Melanocytic Neoplasm With Protein Kinase C Alpha (PRKCA) Fusion.
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Pituitary adenylate cyclase polypeptide (PACAP) stimulates cyclic AMP formation in pituitary fibroblasts and 3T3 tumor fibroblasts: lack of enhancement by protein kinase C activation.
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PKA and PKC activation induces opposite glial fibrillary acidic protein (GFAP) expression and morphology changes in a glioblastoma multiform cell line of clonal origin.
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PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival.
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PKC iota promotes cellular proliferation by accelerated G1/S transition via interaction with CDK7 in esophageal squamous cell carcinoma.
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PKC isozyme S-cysteinylation by cystine stimulates the pro-apoptotic isozyme PKC delta and inactivates the oncogenic isozyme PKC epsilon.
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PKC isozymes and diacylglycerol-regulated proteins as effectors of growth factor receptors.
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PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumors (GIST), especially useful for identifying KIT-negative tumors.
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PKC-? attenuates the cancer stem cell among squamous cell carcinoma cells through down-regulating p63.
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PKC-alpha inhibitor MT477 slows tumor growth with minimal toxicity in in vivo model of non-Ras-mutated cancer via induction of apoptosis.
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PKC-delta inhibitors sustain self-renewal of mouse embryonic stem cells under hypoxia in vitro.
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PKC-delta inhibits anchorage-dependent and -independent growth, enhances differentiation, and increases apoptosis in CaCo-2 cells.
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PKC? and PKM? are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity.
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PKC? in prostate cancer cells represses the recruitment and M2 polarization of macrophages in the prostate cancer microenvironment.
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PKC? inhibits isolation and stemness of side population cells via the suppression of ABCB1 transporter and PI3K/Akt, MAPK/ERK signaling in renal cell carcinoma cell line 769P.
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PKC? promotes generation of reactive oxygen species via DUOX2 in hepatocellular carcinoma.
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PKC? regulates integrin ?V?3 expression and transformed growth of K-ras dependent lung cancer cells.
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PKC? regulates the expression of PDL1 through multiple pathways to modulate immune suppression of pancreatic cancer cells.
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PKC? reveals a tumor promoter function by promoting cell proliferation and migration in somatotropinomas.
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PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1.
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PKCdelta requires p53 for suppression of the transformed phenotype in human colon cancer cells.
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PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells.
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PKCeta associates with cyclin E/Cdk2 complex in serum-starved MCF-7 and NIH-3T3 cells.
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PKCeta enhances cell cycle progression, the expression of G1 cyclins and p21 in MCF-7 cells.
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PKCeta Expression Contributes to the Resistance of Hodgkin's Lymphoma Cell Lines to Apoptosis.
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PKCeta is localized in the Golgi, ER and nuclear envelope and translocates to the nuclear envelope upon PMA activation and serum-starvation: C1b domain and the pseudosubstrate containing fragment target PKCeta to the Golgi and the nuclear envelope.
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PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells.
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Plasma protein kinase C (PKC){alpha} as a biomarker for the diagnosis of cancers.
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Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators.
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Platelet-activating factor stimulates arachidonic acid metabolism in rat liver cells (C-9 cell line) by a receptor-mediated mechanism.
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Platelet-derived growth factor mediated altered expression and regulation of ornithine decarboxylase in H-ras-transformed cell lines.
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Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4.
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Polymyxin B inhibits phorbol 12-myristate 13-acetate, but not chemotactic factor, induced effects in rabbit neutrophils.
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Polyoma virus middle tumor antigen stimulates membrane-associated protein kinase C at lower levels than required for phosphatidylinositol kinase activation and neoplastic transformation.
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Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats.
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Posttranslational regulation of Lck and a p36-38 protein by activators of protein kinase C: differential effects of the tumor promoter, PMA, and the non-tumor-promoter, bryostatin.
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Potassium channel-blockers as therapeutic agents to interfere with bone resorption of periodontal disease.
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Potent induction of human colon cancer cell uptake of chemotherapeutic drugs by N-myristoylated protein kinase C-alpha (PKC-alpha) pseudosubstrate peptides through a P-glycoprotein-independent mechanism.
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Potent peroxisome proliferators inhibit beta-oxidation in the isolated perfused rat liver.
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Potentiation of apoptosis by flavopiridol in mitomycin-C-treated gastric and breast cancer cells.
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Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells.
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Potentiation of diacylglycerol-activated protein kinase C by acyl-coenzyme A thioesters of hypolipidaemic drugs.
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Potentiation of glucocorticoid-mediated induction of the mouse mammary tumor virus promoter in mammary carcinoma cells by activation of protein kinase C.
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Preclinical development of a bifunctional cancer cell homing, PKCepsilon inhibitory peptide for the treatment of head and neck cancer.
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Pretreatment with PKC inhibitor triggers TNF-alpha induced apoptosis in TNF-alpha-resistant B16 melanoma BL6 cells.
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PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim.
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Pro-survival role of protein kinase C epsilon in Philadelphia chromosome positive acute leukemia.
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Production of diacylglycerol, an activator of protein kinase C, by human intestinal microflora.
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Production of tumor necrosis factor alpha in human T lymphocytes by staphylococcal enterotoxin B correlates with toxin-induced proliferation and is regulated through protein kinase C.
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Profiling the interactome of protein kinase C ? by proteomics and bioinformatics.
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Progression of PDMT is accompanied by lack of Fas and intense expression of Bcl-2 and PKC-epsilon.
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Proliferation of human breast cancer cells and anti-cancer action of doxorubicin and vinblastine are independent of PKC-alpha.
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Prospects for targeting protein kinase C isozymes in the therapy of drug-resistant cancer--an evolving story.
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Protection mechanism of early hyperbaric oxygen therapy in rats with permanent cerebral ischemia.
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Protein interacting with C alpha kinase 1 (PICK1) is involved in promoting tumor growth and correlates with poor prognosis of human breast cancer.
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Protein interacting with C kinase 1 suppresses invasion and anchorage-independent growth of astrocytic tumor cells.
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Protein interacting with C-kinase 1 is involved in epithelial-mesenchymal transformation and suppresses progress of gastric cancer.
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Protein kinase C (PKC) activity and PKC messenger RNAs in human pituitary adenomas.
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Protein kinase C (PKC) isoenzyme expression pattern as an indicator of proliferative activity in uterine tumor cells.
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Protein kinase C (PKC) isoenzymes immunohistochemistry in lymph node revealing solution-fixed, paraffin-embedded bladder tumors.
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Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression.
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Protein kinase C ? enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin.
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Protein kinase C ? inhibition by enzastaurin leads to mitotic missegregation and preferential cytotoxicity toward colorectal cancer cells with chromosomal instability (CIN).
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Protein Kinase C ? Modulates Estrogen-Receptor-Dependent Transcription and Proliferation in Endometrial Cancer Cells.
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Protein kinase C ? regulates nuclear pri-microRNA 15a release as part of endothelin signaling.
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Protein Kinase C ?-Responsive Gene Carrier for Cancer-Specific Transgene Expression and Cancer Therapy.
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Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractility.
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Protein kinase C activation increases transepithelial transport of biologically active insulin.
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Protein kinase C activation induces conductance changes in Hermissenda photoreceptors like those seen in associative learning.
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Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets.
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Protein kinase C activation modulates tumour necrosis factor-alpha priming of human neutrophils for zymosan-induced leukotriene B4 release.
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Protein kinase C activation without membrane contact in platelets stimulated by bryostatin.
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Protein kinase C activators of the teleocidin family decrease the IgE-binding capacity of rat basophilic leukemia cells.
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Protein kinase C activities and bindings of a phorbol ester tumor promoter in 41 cell lines.
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Protein kinase C activity and messenger RNA modulation by estrogen in normal and neoplastic rat pituitary tissue.
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Protein kinase C activity can desensitize the gonadotropin-responsive adenylate cyclase in Leydig tumor cells. But hCG-induced desensitization does not involve protein kinase C activation.
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Protein kinase C activity in normal and neoplastic squamous epithelia from the upper aero-digestive tract.
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Protein kinase C agonist and antagonist effects in normal human epidermal keratinocytes.
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Protein Kinase C Alpha (PKC?) overexpression leads to a better response to retinoid acid therapy through Retinoic Acid Receptor Beta (RAR?) activation in mammary cancer cells.
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Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
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Protein kinase C alpha associates with phospholipase D1 and enhances basal phospholipase D activity in a protein phosphorylation-independent manner in human melanoma cells.
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Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice.
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Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer.
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Protein Kinase C alpha is a marker for antiestrogen resistance and is involved in the growth of tamoxifen resistant human breast cancer cells.
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Protein kinase C alpha requirement in the activation of p38 mitogen-activated protein kinase, which is linked to the induction of tumor necrosis factor alpha in lipopolysaccharide-stimulated microglia.
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Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2.
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Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis.
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Protein kinase C alpha-specific peptide substrate graft-type copolymer for cancer cell-specific gene regulation systems.
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Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells.
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Protein kinase C and adenylate cyclase as targets for growth inhibition of human gastric cancer cells.
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Protein kinase C and ERK activation are required for TFF-peptide-stimulated bronchial epithelial cell migration and tumor necrosis factor-alpha-induced interleukin-6 (IL-6) and IL-8 secretion.
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Protein kinase C and its substrates in tumor promoter-sensitive and -resistant cells.
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Protein kinase C as a drug target: implications for drug or diet prevention and treatment of cancer.
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Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.
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Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture.
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Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cells.
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Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.
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Protein kinase C Beta in the tumor microenvironment promotes mammary tumorigenesis.
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Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression.
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Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function.
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Protein kinase C delta activates IkappaB-kinase alpha to induce the p53 tumor suppressor in response to oxidative stress.
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Protein kinase C delta enhances proliferation and survival of murine mammary cells.
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Protein kinase C delta induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38-independent mechanisms.
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Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage.
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Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators.
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Protein kinase C delta is activated in mouse ovarian surface epithelial cancer cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
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Protein kinase C delta is required for survival of cells expressing activated p21RAS.
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Protein kinase C delta negatively modulates canonical wnt pathway and cell proliferation in colon tumor cell lines.
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Protein kinase C epsilon confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53.
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Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy.
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Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas.
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Protein kinase C epsilon mediates the induction of P-glycoprotein in LNCaP prostate carcinoma cells.
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Protein kinase C epsilon regulates tumor necrosis factor-alpha-induced stannin gene expression.
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Protein kinase C epsilon signals ultraviolet light-induced cutaneous damage and development of squamous cell carcinoma possibly through Induction of specific cytokines in a paracrine mechanism.
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Protein kinase C eta is associated with progression of renal cell carcinoma (RCC).
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Protein kinase C family: On the crossroads of cell signaling in skin and tumor epithelium.
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Protein kinase C has both stimulatory and suppressive effects on macrophage superoxide production.
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Protein kinase C in adrenal cells: possible role in regulation of steroid synthesis.
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Protein kinase C in cell signaling: strategies for the development of selective inhibitors.
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Protein kinase C in Wnt signaling: Implications in cancer initiation and progression.
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Protein kinase C independent activation of inducible nitric oxide synthase by tumor necrosis factor-alpha in TM4 Sertoli cells.
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Protein kinase C induces motility of breast cancers by upregulating secretion of urokinase-type plasminogen activator through activation of AP-1 and NF-kappaB.
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Protein kinase C inhibition and x-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells.
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Protein kinase C inhibition by ET-18-OCH3 and related analogs. A target for cancer chemotherapy.
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Protein kinase C inhibitor Gö6976 but not Gö6983 induces the reversion of E- to N-cadherin switch and metastatic phenotype in melanoma: identification of the role of protein kinase D1.
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Protein kinase C inhibitor H-7 blocks effects of tumor necrosis factor on bone cells.
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Protein Kinase C Inhibitor, GF109203X Attenuates Osteoclastogenesis, Bone Resorption and RANKL-Induced NF-?B and NFAT Activity.
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Protein kinase C inhibitors augment tumor-necrosis-factor-induced apoptosis in normal human diploid cells.
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Protein kinase C inhibitors block the enhanced expression of intercellular adhesion molecule-1 on endothelial cells activated by interleukin-1, lipopolysaccharide and tumor necrosis factor.
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Protein kinase C inhibits epidermal growth factor receptor phosphorylation in enterocytes.
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Protein kinase C involvement in interleukin-6 production by parathyroid hormone and tumor necrosis factor-alpha in UMR-106 osteoblastic cells.
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Protein kinase C is activated and diacylglycerol is elevated in epidermal cells from Sencar mice fed high fat diets.
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Protein kinase C is differentially regulated by thrombin, insulin, and epidermal growth factor in human mammary tumor cells.
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Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer.
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Protein kinase C isoform expression and activity alter paclitaxel resistance in vitro.
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Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis.
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Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells).
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Protein Kinase C Isoforms Differentially Regulate Hypoxia-Inducible Factor-1? Accumulation in Cancer Cells.
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Protein kinase C isoforms in multidrug resistant P388/ADR cells: a possible role in daunorubicin transport.
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Protein kinase C isoforms in normal and transformed cells of the melanocytic lineage.
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Protein kinase C isozymes regulate matrix metalloproteinase-1 expression and cell invasion in Helicobacter pylori infection.
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Protein kinase C isozymes, novel phorbol ester receptors and cancer chemotherapy.
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Protein kinase C levels and protein phosphorylation associated with inhibition of proliferation in a murine macrophage tumor.
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Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis.
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Protein kinase C mediated anti-proliferative glucocorticoid-sphinganine synergism in cultured Pollard III prostate tumor cells.
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Protein kinase C mediates tumor necrosis factor-alpha-induced inhibition of obese gene expression and leptin secretion in brown adipocytes.
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Protein kinase C modulates phospholipase C and increases arachidonic acid release in bradykinin stimulated MDCK cells.
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Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling.
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Protein kinase C phosphorylates glutamyl-tRNA synthetase in rabbit reticulocytes stimulated by tumor promoting phorbol esters.
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Protein kinase C phosphorylates the synthetic peptide Arg-Arg-Lys-Ala-Ser-Gly-Pro-Pro-Val in the presence of phospholipid plus either Ca2+ or a phorbol ester tumor promoter.
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Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.
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Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation.
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Protein kinase C regulates macrophage tumor necrosis factor secretion: direct protein kinase C activation restores tumor necrosis factor production in endotoxin tolerance.
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Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells.
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Protein kinase C stimulation enhances the process formation of adult oligodendrocytes and induces proliferation.
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Protein kinase C subspecies in estrogen receptor-positive and -negative human breast cancer cell lines.
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Protein Kinase C Synergistically Stimulates Tumor Necrosis Factor-alpha-Induced Secretion of Urokinase-Type Plasminogen Activator in Human Dental Pulp Cells.
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Protein Kinase C theta (PKCtheta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs).
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Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias.
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Protein kinase C tissue localization in human colonic tumors suggests a role for adenoma growth control.
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Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.
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Protein Kinase C {delta} Is a Downstream Effector of Oncogenic K-ras in Lung Tumors.
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Protein Kinase C {delta} Regulates Ser46 Phosphorylation of p53 Tumor Suppressor in the Apoptotic Response to DNA Damage.
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Protein Kinase C {zeta} is a positive modulator of canonical Wnt signaling pathway in tumoral colon cell lines.
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Protein kinase C-? (PKC?) modulates cell apoptosis by stimulating nuclear translocation of NF-kappa-B p65 in urothelial cell carcinoma of the bladder.
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Protein kinase C-activated oxidant generation in endothelial cells signals intercellular adhesion molecule-1 gene transcription.
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Protein kinase C-activating tumor promoters modulate the DNA damage response in UVC-irradiated TK6 cells.
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Protein kinase C-alpha is an upstream activator of the IkappaB kinase complex in the TPA signal transduction pathway to NF-kappaB in U2OS cells.
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Protein kinase C-alpha is expressed and activated during the development of renal cell carcinoma.
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Protein kinase C-alpha mediates endothelial barrier dysfunction induced by TNF-alpha.
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Protein kinase C-alpha modulates lipopolysaccharide-induced functions in a murine macrophage cell line.
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Protein kinase C-beta inhibitor enzastaurin (LY317615.HCI) enhances radiation control of murine breast cancer in an orthotopic model of bone metastasis.
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Protein kinase C-delta inactivation inhibits the proliferation and survival of cancer stem cells in culture and in vivo.
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Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis.
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Protein kinase C-dependent and -independent pathways mediate epidermal growth factor (EGF) effects in human endometrial adenocarcinoma cell line KLE.
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Protein kinase C-dependent release of a functional whole extracellular domain of the mast cell growth factor (MGF) receptor by MGF-dependent human myeloid cells.
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Protein kinase C-epsilon is the likely mediator of mucin exocytosis in human colonic cell lines.
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Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway.
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Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation.
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Protein kinase C-mediated phosphorylation and desensitization of human alpha(1b)-adrenoceptors.
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Protein kinase C-theta (PKCtheta) distribution analysis in hematopoietic cells: proliferating T cells exhibit high proportions of PKCtheta in the particulate fraction.
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Protein kinase C-zeta mediates TNF-alpha-induced ICAM-1 gene transcription in endothelial cells.
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Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B.
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Protein Kinase C-{alpha} Mediated Regulation of Low-Density Lipoprotein Receptor Related Protein and Urokinase Increases Astrocytoma Invasion.
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Protein kinase C: a key factor in the regulation of tumor cell adhesion to the endothelium.
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Protein kinase C: a potential pathway of endothelial cell activation by endotoxin, tumor necrosis factor, and interleukin-1.
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Protein Kinase C? (PKC?) Regulates p53 Localization and Melanoma Cell Survival Downstream of Integrin ?v in Three-dimensional Collagen and in Vivo.
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Protein kinase C? inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4.
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Protein kinase C? suppresses the expression of STC1 in MDA-MB-231 breast cancer cells.
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Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells.
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Protein kinase Calpha determines HER2 fate in breast carcinoma cells with HER2 protein overexpression without gene amplification.
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Protein kinase calpha is an effector of hexamethylene bisacetamide-induced differentiation of Friend erythroleukemia cells.
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Protein kinase Calpha-responsive polymeric carrier: its application for gene delivery into human cancers.
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Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy.
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Protein kinase Cdelta-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent.
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Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer.
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Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells.
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Protein Kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer.
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Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.
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Protein kinase Cepsilon mediates PMA-induced growth inhibition of low population density NIH 3T3 fibroblasts.
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Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis.
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Protein Kinase C{epsilon} Mediates Polymeric Fibronectin Assembly on the Surface of Blood-borne Rat Breast Cancer Cells to Promote Pulmonary Metastasis.
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Protein kinase D1 mediates NF-kappaB activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells.
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Protein Kinase-zeta inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells.
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Protein kinases A and C positively regulate G protein-dependent activation of phosphatidylinositol-specific phospholipase C by tumor necrosis factor-alpha in MC3T3-E1 osteoblasts.
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Protein kinases C isozymes are differentially expressed in human breast carcinomas.
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Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-kappaB activation.
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Protein phosphorylation in isolated mitochondria and the effects of protein kinase C.
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Proteins kinase C? is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes.
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Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis.
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Proteolytic activation of protein kinase C-epsilon by caspase-mediated processing and transduction of antiapoptotic signals.
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Proteome changes in caco-2 cells treated with monascus-fermented red mold rice extract.
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Proteomic analysis identifies nuclear protein effectors in PKC-delta signaling under high glucose-induced apoptosis in human umbilical vein endothelial cells.
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Proteomic approaches to the analysis of atopic dermatitis and new insights from interactomics.
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Quantitative Study of the Interactome of PKC? Involved in the EGF-induced Tumor Cell Chemotaxis.
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Quercetin enhances susceptibility to NK cell-mediated lysis of tumor cells through induction of NKG2D ligands and suppression of HSP70.
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RACK1 is indispensable for porcine reproductive and respiratory syndrome virus replication and NF-?B activation in Marc-145 cells.
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RACK1 promoted the growth and migration of the cancer cells in the progression of esophageal squamous cell carcinoma.
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RACK1 Suppresses Gastric Tumorigenesis by Stabilizing the ?-Catenin Destruction Complex.
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Radiomimetic cell cycle delay induced by tetranodecanoyl phorbol acetate is enhanced by caffeine and by the protein kinase inhibitor 2-aminopurine.
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Rapid enhancement of beta 2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187.
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Rapid inhibition of intercellular communication between BALB/c 3T3 cells by diacylglycerol, a possible endogenous functional analogue of phorbol esters.
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Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay.
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Rapid modulation of tumor necrosis factor membrane receptors by activators of protein kinase C.
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Rapid phosphorylation of microtubule-associated proteins through distinct mitogenic pathways.
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Rational design and validation of an anti-protein kinase C active-state specific antibody based on conformational changes.
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Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth.
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Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2.
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Receptor for activated protein kinase C 1 suppresses gastric tumor progression through nuclear factor-kB pathway.
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Redistribution and enhanced protein kinase C-mediated phosphorylation of alpha- and gamma-adducin during renal tumor progression.
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Redox regulation of protein kinase C by selenometabolites and selenoprotein thioredoxin reductase limits cancer prevention by selenium.
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Reduced insulin receptor expression and function in human colonic Caco-2 cells by ras and polyoma middle T oncogenes.
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Reduction of Akt2 expression inhibits chemotaxis signal transduction in human breast cancer cells.
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Reduction of PKC alpha decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinoma.
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Regulation of 92-kD gelatinase release in HL-60 leukemia cells: tumor necrosis factor-alpha as an autocrine stimulus for basal- and phorbol ester-induced secretion.
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Regulation of a c-Jun amino-terminal kinase/stress-activated protein kinase cascade by a sodium-dependent signal transduction pathway.
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Regulation of caveolin-1 expression and secretion by a protein kinase cepsilon signaling pathway in human prostate cancer cells.
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Regulation of CCK mRNA in the human neuroepithelioma cell line SK-N-MCIXC in response to second messenger activators.
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Regulation of cyclooxygenases by protein kinase C. Evidence against the importance of direct enzyme phosphorylation.
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Regulation of docetaxel-induced apoptosis of human melanoma cells by different isoforms of protein kinase C.
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Regulation of gelatinases expression by cytokines, endotoxin, and pharmacological agents in the human osteoarthritic knee.
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Regulation of gelatinases in human airway smooth muscle cells: mechanism of progelatinase A activation.
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Regulation of gene expression of tumour necrosis factor-alpha by protein kinase C in the rat dental follicle.
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Regulation of hepatocyte epidermal growth factor receptors by n-butyrate and dimethyl sulfoxide: sensitivity to modulation by the tumor promoter TPA.
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Regulation of interleukin-2 receptor alpha chain expression and nuclear factor.kappa B activation by protein kinase C in T lymphocytes. Autocrine role of tumor necrosis factor alpha.
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Regulation of mammalian ribonucleotide reductase R1 mRNA stability is mediated by a ribonucleotide reductase R1 mRNA 3'-untranslated region cis-trans interaction through a protein kinase C-controlled pathway.
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Regulation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in MCF-7 cells: comparison with regulatory mechanisms of pS2 expression.
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Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes alpha and theta.
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Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells.
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Regulation of nuclear factor kappa B transactivation. Implication of phosphatidylinositol 3-kinase and protein kinase C zeta in c-Rel activation by tumor necrosis factor alpha.
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Regulation of nucleoside transport by lipopolysaccharide, phorbol esters, and tumor necrosis factor-alpha in human B-lymphocytes.
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Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids.
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Regulation of protein kinase C by cyclic adenosine 3':5'-monophosphate and a tumor promoter in skeletal myoblasts.
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Regulation of protein kinase C delta downregulation by protein kinase C epsilon and mammalian target of rapamycin complex 2.
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Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk.
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Regulation of the 12-O-tetradecanoyl-phorbol-13-acetate-induced inhibition of intercellular communication.
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Regulation of the expression and activity of glucose and lactic Acid metabolism-related genes by protein kinase C in skeletal muscle cells.
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Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation.
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Regulation of Transcriptional Networks by PKC Isozymes: Identification of c-Rel as a Key Transcription Factor for PKC-Regulated Genes.
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Regulation of transforming growth factor alpha messenger RNA expression in a chemically transformed rat hepatic epithelial cell line by phorbol ester and hormones.
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Regulation of Transgene Expression in Tumor Cells by Exploiting Endogenous Intracellular Signals.
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Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts.
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Regulation of U-937 monocyte adhesion to cultured human mesangial cells by cytokines and vasoactive agents.
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Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor-promotion susceptibilities of protein kinase C alpha, -delta and -epsilon transgenic mice.
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Relationship of gap junction formation to phosphorylation of connexin43 in mouse preimplantation embryos.
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Repression of 5-aminolevulinate synthase gene by the potent tumor promoter, TPA, involves multiple signal transduction pathways.
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Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction.
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Resveratrol preferentially inhibits protein kinase C-catalyzed phosphorylation of a cofactor-independent, arginine-rich protein substrate by a novel mechanism.
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Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells.
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Retinoblastoma protein-dependent growth signal conflict and caspase activity are required for protein kinase C-signaled apoptosis of prostate epithelial cells.
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Retinoic acid priming potentiates the induction of urokinase-type plasminogen activator by cyclic adenosine monophosphate in mouse mammary carcinoma cells.
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Retinoic acid suppression of c-fos gene inhibits expression of tumor necrosis factor-alpha-induced monocyte chemoattractant JE/MCP-1 in clonal osteoblastic MC3T3-E1 cells.
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Retinoids inhibit the oxidative modification of protein kinase C induced by oxidant tumor promoters.
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Reversible and phorbol ester-specific defect of protein kinase C translocation in hepatocytes isolated from phenobarbital-treated rats.
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Role of 12-lipoxygenase and protein kinase C in modulating the activation state of the integrin alpha IIb beta 3 on human tumor cells.
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Role of AUUU sequences in stabilization of granulocyte-macrophage colony-stimulating factor RNA in stimulated cells.
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Role of dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene 1 in protein kinase A- and protein kinase C-mediated regulation of the steroidogenic acute regulatory protein expression in mouse Leydig tumor cells: mechanism of action.
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Role of intracellular calcium mobilization in the regulation of protein kinase C-mediated membrane processes.
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Role of phorbol ester localization in determining protein kinase C or RasGRP3 translocation: real-time analysis using fluorescent ligands and proteins.
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Role of protein kinase C (PKC) in short- and long-term cellular responses: inhibition of agonist-mediated calcium transients and down-regulation of PKC.
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Role of protein kinase C activity in tumor necrosis factor-alpha gene expression. Involvement at the transcriptional level.
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Role of protein kinase C and cytokines on the function and production of cytolytic granules in alpha CD3-activated killer-cell-mediated killing of tumor cells.
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Role of protein kinase C and intracellular calcium mobilization in the induction of macrophage tumoricidal activity by interferon-gamma.
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Role of protein kinase C and phosphatases in 12(S)-HETE-induced tumor cell cytoskeletal reorganization.
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Role of protein kinase C in regulation of gene expression and relevance to tumor promotion.
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Role of protein kinase C in tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator.
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Role of protein kinase C isoforms in locomotion of Walker 256 carcinosarcoma cells.
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Role of specific interactions between protein kinase C and triphenylethylenes in inhibition of the enzyme.
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Role of the protein kinase C lambda/iota isoform in nuclear factor-kappaB activation by interleukin-1beta or tumor necrosis factor-alpha: cell type specificities.
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Roles of partitioning-defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells.
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Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes.
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Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC ?-independent mechanism.
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Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C.
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Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells.
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Sapintoxin A. A fluorescent phorbol ester that is a potent activator of protein kinase C but is not a tumour promoter.
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Screening for protein kinase C ligands using fluorescence resonance energy transfer.
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Screening of a PKC zeta-specific kinase inhibitor PKCzI257.3 which inhibits EGF-induced breast cancer cell chemotaxis.
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Sealing effects of (-)-epigallocatechin gallate on protein kinase C and protein phosphatase 2A.
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Secretion of matrix metalloproteinase-9 by macrophages, in vitro, in response to Helicobacter pylori.
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Secretions of MMP-9 by soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) mediated by protein kinase C (PKC)delta and phospholipase D (PLD) in murine macrophage.
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Selective low level of protein kinase C isozyme in a tumor promoter-dependent mouse leukemia cell line.
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Selective post-transcriptional down-regulation of protein kinase C isoenzymes in leukemic T cells chronically treated with phorbol ester.
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Selective preservation of protein kinase C-zeta in the chemoprevention of azoxymethane-induced colonic tumors by piroxicam.
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Selective redistribution of protein kinase C isozymes by thapsigargin and staurosporine.
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Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: its role in inhibition of tumor promotion.
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Sensitization of IL-2 Signaling through TLR-7 Enhances B Lymphoma Cell Immunogenicity.
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Sequential Activation of Protein Kinase C Isoforms by Organic Dust is Mediated by Tumor Necrosis Factor.
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Sequestosome 1 protects esophageal squamous carcinoma cells from apoptosis via stabilizing SKP2 under serum starvation condition.
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Serine phosphorylation of p60 tumor necrosis factor receptor by PKC-delta in TNF-alpha-activated neutrophils.
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Serum levels of FAK and some of its effectors in adult AML: correlation with prognostic factors and survival.
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Sex differences in rat hepatic cytolethality of the protein kinase C inhibitor safingol: role of biotransformation.
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Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022).
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Shiga toxin-induced tumor necrosis factor alpha expression: requirement for toxin enzymatic activity and monocyte protein kinase C and protein tyrosine kinases.
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Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species.
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Signal transduction pathways of membrane expression of proteinase 3 (PR-3) in human endothelial cells.
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Signaling pathways responsible for cancer cell invasion as targets for cancer therapy.
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Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells.
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Significance and expression of atypical protein kinase C-iota in human hepatocellular carcinoma.
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Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance.
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Site-dependent differences in response of the UV-2237 murine fibrosarcoma to systemic therapy with adriamycin.
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Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis.
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SLITRK1 Binds 14-3-3 and Regulates Neurite Outgrowth in a Phosphorylation-Dependent Manner.
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Smoke and C5a induce airway epithelial intercellular adhesion molecule-1 and cell adhesion.
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sn-1,2-diacylglycerol levels increase in progesterone-stimulated Xenopus laevis oocytes.
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Specific induction of RGS16 (regulator of G-protein signalling 16) mRNA by protein kinase C in CEM leukaemia cells is mediated via tumour necrosis factor alpha in a calcium-sensitive manner.
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Specific up-regulation of CRH or AVP secretion by acetylcholine or lipopolysaccharide in inflammatory susceptible Lewis rat fetal hypothalamic cells.
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Specificity of DOG1 (K9 clone) and protein kinase C theta (clone 27) as immunohistochemical markers of gastrointestinal stromal tumour.
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Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.
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Spinal NMDA receptor activation constrains inactivity-induced phrenic motor facilitation in Charles River Sprague-Dawley rats.
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Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation.
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Src family kinases phosphorylate protein kinase C delta on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes.
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SSeCKS, a major protein kinase C substrate with tumor suppressor activity, regulates G(1)-->S progression by controlling the expression and cellular compartmentalization of cyclin D.
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Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines.
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Staurosporine induces megakaryocytic differentiation through the upregulation of JAK/Stat3 signaling pathway.
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Staurosporine stimulates expression of the urokinase-type (u-PA) plasminogen activator in LLC-PK1 cells.
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Stimulation of a MR 80,000 protein phosphorylation by EGF in EGF receptor-hyperproducing human tumor cells.
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Stimulation of atrial natriuretic peptide receptor/guanylyl cyclase- A signaling pathway antagonizes the activation of protein kinase C-alpha in murine Leydig cells.
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Stimulation of interleukin-6 promoter by parathyroid hormone, tumor necrosis factor alpha, and interleukin-1beta in UMR-106 osteoblastic cells is inhibited by protein kinase C antagonists.
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Stimulation of prostaglandin E2 production and induction of specific protein synthesis in rat peritoneal macrophages by a tumor promoter staurosporine.
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Stimulation of protein kinase C activity by tumor necrosis factor-alpha in bovine bronchial epithelial cells.
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Stimulatory effect of 1 alpha,25-dihydroxyvitamin D3 on mouse alveolar macrophage tumor necrosis factor-alpha production in vitro: involvement of protein kinase C and Ca2+/calmodulin-dependent kinase.
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Strain-related differences in the pneumotoxic effects of chronically administered butylated hydroxytoluene on protein kinase C and calpain.
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Structural basis of protein kinase C activation by diacylglycerols and tumor promoters.
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Structural insights into the interactions of phorbol ester and bryostatin complexed with protein kinase C: a comparative molecular dynamics simulation study.
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Structural Models for the Design of PKMzeta Inhibitors with Neurobiological Indications.
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Structure-activity studies of the nonphorbol tumor promoter palytoxin in Swiss 3T3 cells.
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Structure/activity relationships of polyfunctional diterpenes of the tigliane type. A pharmacophore model for protein-kinase-C activators based on structure/activity studies and molecular modeling of the tumor promoters 12-O-tetradecanoylphorbol 13-acetate and 3-O-tetradecanoylingenol.
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Studies on protein kinases involved in regulation of nucleocytoplasmic mRNA transport.
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Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells.
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Studies on the mechanism of action of protein kinase C and the isolation of molecular clones encoding the enzyme.
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Subcellular distribution of protein kinase C/phorbol ester receptors in differentiating mouse keratinocytes.
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Suppression by protein kinase C inhibitors of tumor promoter enhancement of Epstein-Barr virus-induced growth transformation.
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Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation.
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Suppression of bcr-abl synthesis by siRNAs or tyrosine kinase activity by Glivec alters different oncogenes, apoptotic/antiapoptotic genes and cell proliferation factors (microarray study).
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Suppression of lipopolysaccharide-dependent tumor necrosis factor alpha induction in rat microglia, in which protein kinase C alpha is down-regulated.
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Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C.
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Suppression of phorbol ester-enhanced radiation-induced malignancy in vitro by protease inhibitors is independent of protein kinase C.
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Suppression of protein kinase C and nuclear oncogene expression as possible action mechanisms of cancer chemoprevention by Curcumin.
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Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin.
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Suppression of protein kinase C and the stimulation of glucocorticoid receptor synthesis by dexamethasone in human fibroblasts derived from tumor tissue.
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Suppression of tumor and metastasis progression through the scaffolding functions of SSeCKS/Gravin/AKAP12.
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Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells.
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Survival pathways regulating the apoptosis induced by tumour necrosis factor-alpha in primary cultured bovine endothelial cells.
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Sustained phospholipase D activation is associated with keratinocyte differentiation.
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Synergistic anti-tumor efficacy of lovastatin and protein kinase C-beta inhibitor in hepatocellular carcinoma.
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Synergistic anticancer effect of exogenous wild-type p53 gene combined with 5-FU in human colon cancer resistant to 5-FU in vivo.
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Synergistic Gene Expression Signature Observed in TK6 Cells upon Co-Exposure to UVC-Irradiation and Protein Kinase C-Activating Tumor Promoters.
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Synergy of tumor necrosis factor with protein kinase C activators on T cell activation.
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Synthesis and anticancer activity of nordihydroguaiaretic acid (NDGA) and analogues.
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Synthesis and Biological Activities of Simplified Analogs of the Natural PKC Ligands, Bryostatin-1 and Aplysiatoxin.
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Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-Lactones as Protein Kinase C Ligands.
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Synthesis and evaluation of novel 7-azaindazolyl-indolyl-maleimide derivatives as antitumor agents and protein kinase C inhibitors.
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Synthesis and protein kinase C (PKC)-C1 domain binding properties of diacyltetrol based anionic lipids.
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Synthesis of oxygenated cholesterols as structural mimics of phorbol ester-type tumor promoters.
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Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes.
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Synthetic diacylglycerols (DAG) and DAG-lactones as activators of protein kinase C (PK-C).
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Synthetic lethal screen of an EGFR-centered network to improve targeted therapies.
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Synthetic lipid second messenger sn-1,2-didecanoylglycerol: a complete tumor promoter in mouse skin.
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Tamoxifen for the treatment of malignancies other than breast and endometrial carcinoma.
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Tamoxifen in the treatment of metastatic malignant melanoma: still a controversy? (Review).
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Tamoxifen suppresses tumor promoter-induced hydrogen peroxide formation by human neutrophils.
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Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNF? in glioblastoma.
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Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling.
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Targeting protein kinase C (PKC) in physiology and cancer of the gastric cell system.
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Targeting protein kinase C by Enzastaurin restrains proliferation and secretion in human pancreatic endocrine tumors.
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Targeting protein kinase C-alpha (PKC-alpha) in cancer with the phosphorothioate antisense oligonucleotide aprinocarsen.
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Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas?
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Targeting the oncogenic protein kinase Ciota signalling pathway for the treatment of cancer.
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Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer.
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Teleocidin and phorbol ester tumor promoters exert similar mitogenic effects on human lymphocytes.
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Tetrandrine Attenuates Cartilage Degeneration, Osteoclast Proliferation, and Macrophage Transformation through Inhibiting P65 Phosphorylation in Ovariectomy-induced Osteoporosis.
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TGF-beta and phorbol esters inhibit mitogenesis utilizing parallel protein kinase C-dependent pathways.
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TGF?-induced phosphorylation of Par6 promotes migration and invasion in prostate cancer cells.
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The 27,000 daltons stress proteins are phosphorylated by protein kinase C during the tumor promoter-mediated growth inhibition of human mammary carcinoma cells.
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The adhesion of anti-CD3-activated mouse T cells to syngeneic colon adenocarcinoma cells is differentially regulated by protein tyrosine kinase-, protein kinase C-, and cAMP-dependent pathways in the effector cell.
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The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities.
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The antitumor activity of doxorubicin against drug-resistant murine carcinoma is enhanced by oral administration of a synthetic staurosporine analogue, CGP 41251.
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The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway.
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The Atypical Protein Kinase C Small Molecule Inhibitor ?-Stat, and Its Effects on Invasion Through Decreases in PKC-? Protein Expression.
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The atypical zeta (zeta) isoform of protein kinase C regulates CD11b/CD18 activation in human neutrophils.
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The bile acid analog fusidic acid can replace phosphatidylserine in the activation of protein kinase C by 12-O-tetradecanoylphorbol-13-acetate in vitro.
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The bisindolylmaleimide protein kinase C inhibitor, Ro 32-2241, reverses multidrug resistance in KB tumour cells.
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The cancer chemopreventive agent resveratrol is incorporated into model membranes and inhibits protein kinase C alpha activity.
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The cDNA sequence, expression pattern and protein characteristics of mouse protein kinase C-zeta.
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The conformations and electrostatic potential maps of phorbol esters, teleocidins and ingenols.
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The core promoter region of the tumor necrosis factor alpha gene confers phorbol ester responsiveness to upstream transcriptional activators.
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The crucial role of cyclooxygenase-2 in osteopontin-induced protein kinase C alpha/c-Src/IkappaB kinase alpha/beta-dependent prostate tumor progression and angiogenesis.
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The duration of phorbol-inducible ErbB2 tyrosine dephosphorylation parallels that of receptor endocytosis rather than threonine-686 phosphorylation: implications for the physiological role of protein kinase C in growth factor receptor signalling.
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The effect of bryostatin on protein kinase C-regulated functions in human T lymphocytes and epidermal keratinocytes.
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The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro.
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The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiation.
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The effect of phorbol esters on cell growth and epidermal growth factor receptor modulation in a human gastric carcinoma cell line TMK-1.
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The effect of plant phenols on the expression and activity of phorbol ester-induced PKC in mouse epidermis.
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The effect of sulindac on colon polyps: circumvention of a transformed phenotype--a hypothesis.
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The effects of glucocorticoids on phorbol ester and cytokine stimulated transcription factor activation in human lung.
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The effects of staurosporine and okadaic acid on baby hamster kidney fibroblast cell adhesion.
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The effects of teleocidin and aplysiatoxin tumor promoters on epithelial tight junctions and transepithelial permeability: comparison to phorbol esters.
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The essential role of PKCalpha in the protective effect of heat-shock pretreatment on TNFalpha-induced apoptosis in hepatic epithelial cell line.
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The expression and down stream effect of lectin like-oxidized low density lipoprotein 1 (LOX-1) in hyperglycemic state.
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The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma.
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The expression of microRNAs and exposure to environmental contaminants related to human health: a review.
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The identification of four protein kinase C isoforms in human glioblastoma cell lines: PKC alpha, gamma, epsilon, and zeta.
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The IGF-I Receptor Can Alter the Matrix Metalloproteinase Repertoire of Tumor Cells through Transcriptional Regulation of PKC-{alpha}
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The in vivo effect of bryostatin-1 on paclitaxel-induced tumor growth, mitotic entry, and blood flow.
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The induction of orphan nuclear receptor Nur77 expression by n-butylenephthalide as pharmaceuticals on hepatocellular carcinoma cell therapy.
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The inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta stimulate phosphatidylcholine secretion in primary cultures of rat type II pneumocytes.
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The inhibitory effects of bryostatin 1 administration on the growth of rabbit papillomas.
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The involvement of catecholamines and polypeptide hormones in the multihormonal modulation of rat hepatic zinc thionein levels.
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The involvement of novel protein kinase C isozymes in influencing sensitivity of breast cancer MCF-7 cells to tumor necrosis factor-alpha.
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The involvement of protein kinase C isoenzymes alpha, epsilon and zeta in the sensitivity to antitumor treatment and apoptosis induction.
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The involvement of protein kinase C, calcium, and 5-lipoxygenase in the production of tumor necrosis factor by a cloned interleukin-3 dependent cell line with natural cytotoxic activity.
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The isoquinoline sulfonamide H7 attenuates radiation-mediated protein kinase C activation and delays the onset of x-ray-induced G2 arrest.
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The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex.
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The mechanism for protein kinase C inhibition of androgen production and 17alpha-hydroxylase expression in a theca cell tumor model.
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The mechanism of skin tumor promotion caused by phorbol esters: possible involvement of arachidonic acid cascade/lipoxygenase, protein kinase C and calcium/calmodulin systems.
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The membrane immunoglobulin receptor utilizes a Shc/Grb2/hSOS complex for activation of the mitogen-activated protein kinase cascade in a B-cell line.
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The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-kappaB.
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The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines.
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The osteogenic or adipogenic lineage commitment of human mesenchymal stem cells is determined by protein kinase C delta.
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The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors.
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The phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate stimulates the dephosphorylation of mitochondrial ferredoxin in cultured chick kidney cells.
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The phospholipid- and calcium-dependent protein kinase as a target in tumor chemotherapy.
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The PKCalpha-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals.
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The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas.
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The Pros and Cons of Targeting Protein Kinase c (PKC) in the Management of Cancer Patients.
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The protective effect of phorbol esters on Fas-mediated apoptosis in T cells. Transcriptional and postranscriptional regulation.
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The protective effects of the native flavanone flavanomarein on neuronal cells damaged by 6-OHDA.
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The protein kinase C activator L-alpha-dioctanoylglycerol: a potent stage II mouse skin tumor promoter.
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The Protein Kinase C Agonist PEP005 (Ingenol 3-Angelate) in the Treatment of Human Cancer: A Balance between Efficacy and Toxicity.
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The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A.
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The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients.
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The protein kinase C inhibitor, bisindolylmaleimide, inhibits the TPA-induced but not the TNF-induced increase in LLC-PK1 transepithelial permeability.
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The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2.
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The protein kinase C-related PKC-L(eta) gene product is localized in the cell nucleus.
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The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts.
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The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer.
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The regulation of protein kinase C by chenodeoxycholate, deoxycholate and several structurally related bile acids.
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The respiratory burst of granulocytes: modulation by inflammatory mediators and its mechanism.
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The role of 80K/MARCKS, a specific substrate of protein kinase C, in cell growth and tumour progression.
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The role of free oxygen radicals in the expulsion of primary infections of Nippostrongylus brasiliensis.
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The role of P38 MAPK and PKC in BLP induced TNF-alpha release, apoptosis, and NFkappaB activation in THP-1 monocyte cells.
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The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt.
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The role of protein glycosylation inhibitors in the prevention of metastasis and therapy of cancer.
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The role of protein kinase C (PKC) in the evolution and proliferation of malignant gliomas, and the application of PKC inhibition as a novel approach to anti-glioma therapy.
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The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).
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The role of protein kinase C in cell surface signal transduction and tumour promotion.
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The role of protein kinase C in interleukin 1 and tumor necrosis factor alpha induction of fibroblasts to produce and release granulocyte-macrophage colony-stimulating activity.
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The role of protein kinase C in migration of rat glioma cells from spheroid cultures.
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The role of protein kinase C in the induction of VCAM-1 expression on human umbilical vein endothelial cells.
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The role of protein kinase C-alpha (PKC-alpha) in cancer and its modulation by the novel PKC-alpha-specific inhibitor aprinocarsen.
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The role of protein kinase C-alpha (PKC-alpha) in malignancies of the gastrointestinal tract.
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The role of protein kinase C-alpha in malignancies of the nervous system and implications for the clinical development of the specific PKC-alpha inhibitor aprinocarsen (Review).
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The role of protein kinase-C theta in control of epithelial to mesenchymal transition and cancer stem cell formation.
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The role of SSeCKS/gravin/AKAP12 scaffolding proteins in the spaciotemporal control of signaling pathways in oncogenesis and development .
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The role of the phorbol ester receptor/protein kinase C in the sensitivity of leukemic cells to anthracyclines.
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The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity.
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The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature.
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The Src-suppressed C kinase substrate, SSeCKS, is a potential metastasis inhibitor in prostate cancer.
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The stereochemical requirement for protein kinase C activation by 3-methyldiglycerides matches that found in naturally occurring tumor promoters aplysiatoxins.
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The stimulation of prostaglandin production by transforming growth factor-alpha and 12-O-tetradecanoyl-phorbol-13-acetate or 1-oleoyl-2-acetyl-glycerol is synergistic.
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The strong induction of metallothionein gene following cadmium exposure transiently affects the expression of many genes in Eisenia fetida: a trade-off mechanism?
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The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease.
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The therapeutic role of targeting protein kinase C in solid and hematologic malignancies.
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The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands.
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The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) provokes a prolonged morphologic response and ERK activation in Tsc2-null renal tumor cells.
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The tumor promoter receptor protein kinase C: a novel target for chemoprevention and therapy of human colon cancer.
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The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.
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Thermostable direct hemolysin diminishes tyrosine phosphorylation of epidermal growth factor receptor through protein kinase C dependent mechanism.
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Three activators of protein kinase C, bryostatins, dioleins, and phorbol esters, show differing specificities of action on GH4 pituitary cells.
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Thyrocytes isolated from autoimmune-diseased thyroids secrete soluble tumor necrosis factor-R1 that is related to their elevated protein kinase C activity.
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Thyroid hormones increase inducible nitric oxide synthase gene expression downstream from PKC-zeta in murine tumor T lymphocytes.
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TIS21 ( /BTG2/PC3 ) as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule.
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TNF-alpha induces peroxynitrite-mediated depletion of lung endothelial glutathione via protein kinase C.
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TNF-induced activation of pulmonary microvessel endothelial cells: a role for GSK3beta.
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TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes.
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TNF-stimulated arginine transport by human vascular endothelium requires activation of protein kinase C.
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Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells.
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Topical application of a novel immunomodulatory peptide, RDP58, reduces skin inflammation in the phorbol ester-induced dermatitis model.
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Toward a Biorelevant Structure of Protein Kinase C Bound Modulators: Design, Synthesis, and Evaluation of Labeled Bryostatin Analogues for Analysis with Rotational Echo Double Resonance NMR Spectroscopy.
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Toward the development of new medicinal leads with selectivity for protein kinase C isozymes.
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Toxic shock syndrome toxin-1 induces inositol phospholipid turnover, protein kinase C translocation, and calcium mobilization in human T cells.
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Toxicodynamics of tumour promoters of mouse skin. II. Binding to protein kinase C of some new diterpene esters and induction of luminol-enhanced chemoluminescence in mouse peritoneal neutrophils.
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Transcriptional induction of protein kinase C delta by p53 tumor suppressor in the apoptotic response to DNA damage.
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Transcriptional repression of protein kinase Calpha via Sp1 by wild type p53 is involved in inhibition of multidrug resistance 1 P-glycoprotein phosphorylation.
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Transduction of retinoic acid and gamma-interferon signal for intercellular adhesion molecule-1 expression on human tumor cell lines: evidence for the late-acting involvement of protein kinase C inactivation.
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Transformation by a ras oncogene causes increased expression of protein kinase C-alpha and decreased expression of protein kinase C-epsilon.
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Transforming growth factor beta activates protein kinase C in microvessels isolated from immature rat brain.
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Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.
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Transgenic overexpression of PKC? in the mouse prostate induces preneoplastic lesions.
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Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes.
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Translocation and activation of protein kinase C by the plasma cell tumor-promoting alkane pristane.
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Translocation of protein kinase C from cytosol to membrane fractions in human epidermal keratinocytes by recombinant human interferon-gamma.
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Translocation of protein kinase C isoenzymes by elevated extracellular Ca2+ concentration in cells from a human giant cell tumor of bone.
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Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C-alpha phosphorothioate oligodeoxynucleotide.
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Treatment with
Pluchea indica
(L.) Less. leaf ethanol extract alleviates liver injury in multiple low-dose streptozotocin-induced diabetic BALB/c mice.
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Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice.
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Tumor cell adherence to cultured capillary endothelial cells is promoted by activators of protein kinase C.
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Tumor cell-mediated induction of the stromal factor stromelysin-3 requires heterotypic cell contact-dependent activation of specific protein kinase C isoforms.
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Tumor grade-dependent alterations in the protein kinase C isoform pattern in urinary bladder carcinomas.
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Tumor necrosis factor alpha induces endothelial galactosyl transferase activity and verocytotoxin receptors. Role of specific tumor necrosis factor receptors and protein kinase C.
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Tumor necrosis factor alpha modifies agonist-dependent responses in human neutrophils by inducing the synthesis and myristoylation of a specific protein kinase C substrate.
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Tumor necrosis factor alpha-induced activation of downstream NF-kappaB site of the promoter mediates epithelial ICAM-1 expression and monocyte adhesion. Involvement of PKCalpha, tyrosine kinase, and IKK2, but not MAPKs, pathway.
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Tumor necrosis factor gene expression is mediated by protein kinase C following activation by ionizing radiation.
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Tumor necrosis factor increases stability of interleukin-1 mRNA by activating protein kinase C.
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Tumor necrosis factor induction of endothelial cell surface antigens is independent of protein kinase C activation or inactivation. Studies with phorbol myristate acetate and staurosporine.
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Tumor necrosis factor mediates apoptosis via Ca++/Mg++ dependent endonuclease with protein kinase C as a possible mechanism for cytokine resistance in human renal carcinoma cells.
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Tumor necrosis factor production by Kupffer cells requires protein kinase C activation.
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Tumor necrosis factor receptor type-1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat.
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Tumor necrosis factor receptors and cytocidal activity are down-regulated by activators of protein kinase C.
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Tumor necrosis factor signal transduction. Cell-type-specific activation and translocation of protein kinase C.
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Tumor necrosis factor-alpha activates pulmonary artery endothelial protein kinase C.
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Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C.
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Tumor necrosis factor-alpha decreases pulmonary artery endothelial nitrovasodilator via protein kinase C.
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Tumor necrosis factor-alpha down regulates sodium current in skeletal muscle by protein kinase C activation: involvement in critical illness polyneuromyopathy.
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Tumor necrosis factor-alpha enhances hypoxia-reoxygenation-mediated apoptosis in cultured human coronary artery endothelial cells: critical role of protein kinase C.
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Tumor necrosis factor-alpha inhibits Schwann cell proliferation by up-regulating Src-suppressed protein kinase C substrate expression.
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Tumor necrosis factor-alpha mediates pancreatitis responses in acinar cells via protein kinase C and proline-rich tyrosine kinase 2.
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Tumor necrosis factor-alpha, platelet-activating factor, and hydrogen peroxide activate protein kinase C subtypes alpha and epsilon in human saphenous vein endothelial cells.
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Tumor necrosis factor-alpha- and interleukin-1-stimulated intercellular adhesion molecule-1 expression by murine renal tubular epithelial cells is transcriptionally regulated and involves protein kinase C.
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Tumor promoter 12-O-tetradecanoylphorbol-13-acetate and sn-1,2-dioctanoylglycerol increase the phosphorylation of protein kinase C in cells.
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Tumor promoter benzoyl peroxide induces sulfhydryl oxidation in protein kinase C: its reversibility is related to the cellular resistance to peroxide-induced cytotoxicity.
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Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s.
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Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis.
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Tumor promoter-stimulated protein phosphorylation in mouse epidermis is inhibited by bromophenacyl bromide.
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Tumor promoters accentuate phosphorylation of PO: evidence for the presence of protein kinase C in purified PNS myelin.
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Tumor promoters as probes of protein kinase C in dog thyroid cell: inhibition of the primary effects of carbamylocholine and reproduction of some distal effects.
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Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.
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Tumor promoters enhance basal and growth hormone releasing factor stimulated cyclic AMP levels in anterior pituitary cells.
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Tumor promoters induce basic fibroblast growth factor gene expression in human dermal fibroblasts.
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Tumor promoters stimulate the formation of 1,2-diacylglycerol in murine peritoneal macrophages: a possible mechanism for stimulating superoxide anion radical production.
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Tumor-induced endothelial cell apoptosis: roles of NAD(P)H oxidase-derived reactive oxygen species.
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Tumor-mediated inhibition of dendritic cell differentiation is mediated by down regulation of protein kinase C beta II expression.
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Tumor-promoting phorbol ester and ras oncogene expression inhibit the glucocorticoid-dependent transcription from the mouse mammary tumor virus long terminal repeat.
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Tumor-promoting phorbol esters stimulate bovine cerebral cortex capillary endothelial cell growth in vitro.
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Tumorigenicity-associated expression of protein kinase C isoforms in rhabdomyosarcoma-derived cells.
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Tumour necrosis factor alpha mediates transient receptor potential vanilloid 1-dependent bilateral thermal hyperalgesia with distinct peripheral roles of interleukin-1beta, protein kinase C and cyclooxygenase-2 signalling.
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Tumour necrosis factor-alpha induces translocation of protein kinase C in tumour necrosis factor-sensitive cell lines.
Neoplasms
Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts. Possible molecular mechanisms.
Neoplasms
Two independent growth factor-generated signals regulate c-fos and c-myc mRNA levels in Swiss 3T3 cells.
Neoplasms
Two-dimensional gel electrophoresis analyses identify nucleophosmin as an estrogen regulated protein associated with acquired estrogen-independence in human breast cancer cells.
Neoplasms
UCN-01 (7-hydroxystaurosporine) inhibits the growth of human breast cancer xenografts through disruption of signal transduction.
Neoplasms
UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line.
Neoplasms
UCN-01, a protein kinase C inhibitor, inhibits endothelial cell proliferation and angiogenic hypoxic response.
Neoplasms
Ultrasound contrast agents can influence the respiratory burst activity of human neutrophil granulocytes.
Neoplasms
Ultraviolet radiation and 12-O-tetradecanoylphorbol-13-acetate-induced interaction of mouse epidermal protein kinase C ? with Stat3 involve integration with Erk1/2.
Neoplasms
Unconventional Secretion of PKC? Exerts Tumorigenic Function via Stimulation of ERK1/2 Signaling in Liver Cancer.
Neoplasms
Uneven distribution of protein kinase C-alpha and -beta isozymes in human sarcomas and carcinomas.
Neoplasms
Unravelling Structure, Localization, and Genetic Crosstalk of KLF3 in Human Breast Cancer.
Neoplasms
Up-regulation of intracellular signalling pathways may play a central pathogenic role in hypertension, atherogenesis, insulin resistance, and cancer promotion--the 'PKC syndrome'.
Neoplasms
Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors.
Neoplasms
Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells.
Neoplasms
Upregulation of the EP1 receptor for prostaglandin E(2) promotes skin tumor progression.
Neoplasms
Urinary trypsin inhibitor, a Kunitz-type protease inhibitor, modulates tumor necrosis factor-stimulated activation and translocation of protein kinase C in U937 cells.
Neoplasms
Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration.
Neoplasms
What the Genetic Background of Individuals with Asthma and Obesity Can Reveal: Is ?2-Adrenergic Receptor Gene Polymorphism Important?
Neoplasms
Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A.
Neoplasms
Wortmannin has opposite effects on phorbol ester-induced DNA synthesis and phosphatidylcholine hydrolysis.
Neoplasms
Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: comparison with fat cells.
Neoplasms
X-linked inhibitor of apoptosis protein levels and protein kinase C activity regulate the sensitivity of human endometrial carcinoma cells to tumor necrosis factor alpha-induced apoptosis.
Neoplasms
Zinc binding site in PICK1 is dominantly located at the CPC motif of its PDZ domain.
Neoplasms
[Activation of protein kinase C and cAMP-dependent protein kinase in hormone-dependent mammary gland tumors during stimulation of their growth with progesterone and estrone]
Neoplasms
[An experimental study on the capability of laminin receptor antibody and protein kinase C inhibitor to inhibit tumor metastasis in vivo]
Neoplasms
[Effects of protein kinase C activator and inhibitor on release of tumor necrosis factor from mouse peritoneal macrophages]
Neoplasms
[Inhibitory effects of protein kinase C inhibitor and calmodulin antagonist on tumor necrosis factor production by mouse macrophages]
Neoplasms
[Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries]
Neoplasms
[Multidrug resistance increase of tumor cells at the effect of radiation and phorbol ether depends on protein kinase C and reactive oxygen species]
Neoplasms
[Possible modes of action of growth factors and tumor promoters in the activation of the c-myc gene in Swiss 3T3 fibroblasts]
Neoplasms
[Study on the mechanism of reversing multidrug resistance of hepatocarcinoma by bromocriptine]
Neoplasms
[Suppressive effect of protein kinase C inhibitors on tumor cell function via phosphorylation of p53 protein in mice]
Neoplasms
[The actions of TPA-type as well as non-TPA type tumor promoters and their mechanism(s) in tumor promotion]
Neoplasms
[The CCNB1, HER2, and PKC silencing induced by small interfering RNA decreases a division of different human cancer cells with interfering RNA decreases a different efficiency]
Neoplasms
[The clinical signifcance of expression of ERCC1 and PkCalpha in non-small cell lung cancer]
Neoplasms
[The effect of alpha-tocopherol over a wide range of concentrations (10(-2)-10(-17) M) on protein kinase C activity. Connection with proliferation and tumor growth]
Neoplasms
[The effect of protein kinase C on the invasive behavior of human salivary adenoid cystic carcinoma in vitro]
Neoplasms
[The role of PKC to TNF-alpha induced beta-1, 4-galactosyltransferase-I expression in endothelial cells].
Neoplasms
[The role of protein kinase C alpha in recurrence of superficial bladder carcinoma]
Neoplasms
[The role of protein kinase C in cell surface signal transduction and tumor promotion]
Neoplasms
[The role of protein kinase C in the adenylate cyclase activation by estradiol in the plasma membranes of estradiol-dependent tumors]
Neoplasms
[Translocation of protein kinase C from cytosol into cell membranes after treatment with estradiol and enzyme activation in target cells]
Nervous System Diseases
Bryostatin Effects on Cognitive Function and PKC? in Alzheimer's Disease Phase IIa and Expanded Access Trials.
Nervous System Diseases
How protein kinase C activation protects nerve cells from oxidative stress-induced cell death.
Nervous System Diseases
Protein Interacting with C-Kinase 1 Deficiency Impairs Glutathione Synthesis and Increases Oxidative Stress via Reduction of Surface Excitatory Amino Acid Carrier 1.
Nervous System Diseases
Protein kinase C deficiency-induced alcohol insensitivity and underlying cellular targets in Drosophila.
Nervous System Diseases
Protein kinase C isoforms as therapeutic targets in nervous system disease states.
Nervous System Diseases
Rottlerin protected dopaminergic cell line from cytotoxicity of 6-hydroxydopamine by inhibiting PKCdelta phosphorylation.
Nervous System Diseases
Structural Models for the Design of PKMzeta Inhibitors with Neurobiological Indications.
Nervous System Neoplasms
The role of protein kinase C-alpha in malignancies of the nervous system and implications for the clinical development of the specific PKC-alpha inhibitor aprinocarsen (Review).
Neural Tube Defects
Developmental expression of MARCKS and protein kinase C in mice in relation to the exencephaly resulting from MARCKS deficiency.
Neural Tube Defects
Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy.
Neural Tube Defects
Protein kinase C?2 inhibition reduces hyperglycemia-induced neural tube defects through suppression of a caspase 8-triggered apoptotic pathway.
Neural Tube Defects
Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol.
Neuralgia
A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain.
Neuralgia
Activation of medullary dorsal horn ? isoform of protein kinase C interneurons is essential to the development of both static and dynamic facial mechanical allodynia.
Neuralgia
Anti-allodynic effect of the flavonoid myricetin in a rat model of neuropathic pain: Involvement of p38 and protein kinase C mediated modulation of Ca(2+) channels.
Neuralgia
Biphasic effects of chronic intrathecal gabapentin administration on the expression of protein kinase C gamma in the spinal cord of neuropathic pain rats.
Neuralgia
Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions.
Neuralgia
Differential effects of NMDA and group I mGluR antagonists on both nociception and spinal cord protein kinase C translocation in the formalin test and a model of neuropathic pain in rats.
Neuralgia
Effect of PKC/NF-?B on the Regulation of P2X3 Receptor in Dorsal Root Ganglion in Rats with Sciatic Nerve Injury.
Neuralgia
Estrogen controls PKCepsilon-dependent mechanical hyperalgesia through direct action on nociceptive neurons.
Neuralgia
Expression of central glucocorticoid receptors after peripheral nerve injury contributes to neuropathic pain behaviors in rats.
Neuralgia
FSC231 can alleviate paclitaxel-induced neuralgia by inhibiting PICK1 and affecting related factors.
Neuralgia
Hypericin, a Naphthodianthrone Derivative, Prevents Methylglyoxal-Induced Human Endothelial Cell Dysfunction.
Neuralgia
Identification of differentially expressed proteins in the spinal cord of neuropathic pain models with PKCgamma silence by proteomic analysis.
Neuralgia
Implication of spinal protein kinase C in the suppression of morphine-induced rewarding effect under a neuropathic pain-like state in mice.
Neuralgia
Influence of intrathecal injection with dexmedetomidine on the behavioral ability and analgesic effects on rats with neuropathic pain and expression of protein kinase C in the spinal dorsal horn.
Neuralgia
Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury.
Neuralgia
Involvement of Spinal PKM? Expression and Phosphorylation in Remifentanil-Induced Long-Term Hyperalgesia in Rats.
Neuralgia
mGlu5 receptor and protein kinase C implicated in the development and induction of neuropathic pain following chronic ethanol consumption.
Neuralgia
Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain.
Neuralgia
Neurochemical characterization of neuronal populations expressing protein kinase C gamma isoform in the spinal cord and gracile nucleus of the rat.
Neuralgia
Neuropathic pain and temporal expression of preprodynorphin, protein kinase C and N-methyl-D-aspartate receptor subunits after spinal cord injury.
Neuralgia
Pain behaviors after spinal cord contusion injury in two commonly used mouse strains.
Neuralgia
Pain modulation effect on motor cortex after optogenetic stimulation in shPKC? knockdown dorsal root ganglion-compressed Sprague-Dawley rat model.
Neuralgia
Pain-related increases in spinal cord membrane-bound protein kinase C following peripheral nerve injury.
Neuralgia
Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1.
Neuralgia
Presynaptic N-Methyl-d-aspartate (NMDA) Receptor Activity Is Increased Through Protein Kinase C in Paclitaxel-induced Neuropathic Pain.
Neuralgia
Protein kinase C gamma-mediated phosphorylation of GluA1 in the postsynaptic density of spinal dorsal horn neurons accompanies neuropathic pain, and dephosphorylation by calcineurin is associated with prolonged analgesia.
Neuralgia
Regulation of mu opioid receptor mRNA levels by activation of protein kinase C in human SH-SY5Y neuroblastoma cells.
Neuralgia
Solid-phase synthesis, mass spectrometric analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma.
Neuralgia
Structural Models for the Design of PKMzeta Inhibitors with Neurobiological Indications.
Neuralgia
The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKC?.
Neuralgia
The association of neuropathic pain, morphine tolerance and dependence, and the translocation of protein kinase C.
Neuralgia
[Effect of intrathecal sufentanil and protein kinase C inhibitor on pain threshold and the expression of NMDA receptor/ CGRP in spinal dorsal horn in rats with neuropathic pain].
Neuralgia, Postherpetic
The Safety and Efficacy of KAI-1678- An Inhibitor of Epsilon Protein Kinase C (?PKC)-Versus Lidocaine and Placebo for the Treatment of Postherpetic Neuralgia: A Crossover Study Design.
Neurilemmoma
DOG1 Utility in diagnosing gastrointestinal stromal tumors on fine-needle aspiration.
Neurilemmoma
PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumors (GIST), especially useful for identifying KIT-negative tumors.
Neuritis
Characterization and differential expression of protein kinase C isoforms in PC12 cells. Differentiation parallels an increase in PKC beta II.
Neuroblastoma
(-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells.
Neuroblastoma
1,25-dihydroxyvitamin D3 regulates the expression of N-myc, c-myc, protein kinase C, and transforming growth factor-beta2 in neuroblastoma cells.
Neuroblastoma
?-N-oxalyl-L-?,?-diaminopropionic acid regulates mitogen-activated protein kinase signaling by down-regulation of phosphatidylethanolamine-binding protein 1.
Neuroblastoma
A critical protein kinase C phosphorylation site on the 5-HT(1A) receptor controlling coupling to N-type calcium channels.
Neuroblastoma
A novel PIP2 binding of epsilonPKC and its contribution to the neurite induction ability.
Neuroblastoma
A PKCbeta isoform mediates phorbol ester-induced activation of Erk1/2 and expression of neuronal differentiation genes in neuroblastoma cells.
Neuroblastoma
A protein kinase C-activating phorbol ester enhances transcription of the human DBH gene through a cyclic AMP response element in SK-N-BE(2)C cells.
Neuroblastoma
A protein kinase Cbeta inhibitor attenuates multidrug resistance of neuroblastoma cells.
Neuroblastoma
A role for protein kinase C subtypes alpha and epsilon in phorbol-ester-enhanced K(+)- and carbachol-evoked noradrenaline release from the human neuroblastoma SH-SY5Y.
Neuroblastoma
A specific inhibitor of protein kinase C induces differentiation of neuroblastoma cells.
Neuroblastoma
Acrylonitrile-induced extracellular signal-regulated kinase (ERK) activation via protein kinase C (PKC) in SK-N-SH neuroblastoma cells.
Neuroblastoma
Actinomycin D decreases protein kinase C content and induces neuritogenesis in neuroblastoma cells.
Neuroblastoma
Activation of phospholipase D in SH-SY5Y neuroblastoma cells: dependence on Ca2+ and protein kinase C.
Neuroblastoma
Activation of protein kinase C in permeabilized human neuroblastoma SH-SY5Y cells.
Neuroblastoma
Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells.
Neuroblastoma
Activation of protein kinase C-alpha and translocation of the myristoylated alanine-rich C-kinase substrate correlate with phorbol ester-enhanced noradrenaline release from SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Activation of Ras, Raf-1 and protein kinase C in differentiating human neuroblastoma cells after treatment with phorbolester and NGF.
Neuroblastoma
Acute regulation of norepinephrine transport: II. PKC-modulated surface expression of human norepinephrine transporter proteins.
Neuroblastoma
Additive effects of basic fibroblast growth factor and phorbol ester on beta-amyloid precursor protein expression and secretion.
Neuroblastoma
Apoptosis induced by protein kinase C inhibition in a neuroblastoma cell line.
Neuroblastoma
Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells.
Neuroblastoma
Autophosphorylation suppresses whereas kinase inhibition augments the translocation of protein kinase Calpha in response to diacylglycerol.
Neuroblastoma
Basic FGF and IGF-I promote differentiation of human SH-SY5Y neuroblastoma cells in culture.
Neuroblastoma
Bradykinin-induced generation of inositol 1,4,5-trisphosphate in fibroblasts and neuroblastoma cells: effect of pertussis toxin, extracellular calcium, and down-regulation of protein kinase C.
Neuroblastoma
Bradykinin-induced phosphoinositide-dependent responses in protein kinase C down-regulated NCB-20 cells.
Neuroblastoma
Calcium influx into human neuroblastoma cells induces ALZ-50 immunoreactivity: involvement of calpain-mediated hydrolysis of protein kinase C.
Neuroblastoma
Caveolin-1 upregulation in senescent neurons alters amyloid precursor protein processing.
Neuroblastoma
Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a.
Neuroblastoma
Ceramide influences neurite outgrowth and neuroblastoma cell apoptosis regulated by novel protein kinase C isoforms.
Neuroblastoma
Cholinergic muscarinic mechanisms regulate neuropeptide Y gene expression via protein kinase C in human neuroblastoma cells.
Neuroblastoma
Chronic effects of ethanol on muscarinic acetylcholine receptors are modulated by protein kinase C.
Neuroblastoma
cis-Fatty acids, which activate protein kinase C, attenuate Na+ and Ca2+ currents in mouse neuroblastoma cells.
Neuroblastoma
Contrasting effects of phorbol ester and agonist-mediated activation of protein kinase C on phosphoinositide and Ca2+ signalling in a human neuroblastoma.
Neuroblastoma
Degradation of protein kinase C alpha and its free catalytic subunit, protein kinase M, in intact human neuroblastoma cells and under cell-free conditions. Evidence that PKM is degraded by mM calpain-mediated proteolysis at a faster rate than PKC.
Neuroblastoma
Desensitization of muscarinic M1 receptors of murine neuroblastoma cells (clone N1E-115) without receptor down-regulation and protein kinase C activity.
Neuroblastoma
Diacylglycerol-induced activation of protein kinase C attenuates Na+ currents by enhancing inactivation from the closed state.
Neuroblastoma
Differential effects of the protein kinase C inhibitors H7 and calphostin C on the cell cycle of neuroblastoma cells.
Neuroblastoma
Differential expression and subcellular localization of protein kinase C alpha, beta, gamma, delta, and epsilon isoforms in SH-SY5Y neuroblastoma cells: modifications during differentiation.
Neuroblastoma
Differential expression of MARCKS and other calmodulin-binding protein kinase C substrates in cultured neuroblastoma and glioma cells.
Neuroblastoma
Differential expression of protein kinase C subtypes during ginsenoside Rh2-lnduced apoptosis in SK-N-BE(2) and C6Bu-1 cells.
Neuroblastoma
Differential involvement of protein kinase C alpha and epsilon in the regulated secretion of soluble amyloid precursor protein.
Neuroblastoma
Differential nuclear localization of protein kinase C isoforms in neuroblastoma x glioma hybrid cells.
Neuroblastoma
Differential responses of staurosporine on protein kinase C activity and proliferation in two murine neuroblastoma cell lines.
Neuroblastoma
Direct modulation of Na+ currents by protein kinase C activators in mouse neuroblastoma cells.
Neuroblastoma
Dissociation of phosphorylation and translocation of a myristoylated protein kinase C substrate (MARCKS protein) in C6 glioma and N1E-115 neuroblastoma cells.
Neuroblastoma
Distinct mechanisms of differentiation of SH-SY5Y neuroblastoma cells by protein kinase C activators and inhibitors.
Neuroblastoma
Down-regulation of protein kinase C alpha and gamma and enhanced TPA-induced neurite formation in DAN-transfected neuroblastoma cells.
Neuroblastoma
Down-regulation or long-term inhibition of protein kinase C (PKC) reduces noradrenaline release evoked via either PKC-dependent or PKC-independent pathways in human SH-SY5Y neuroblastoma cells.
Neuroblastoma
Effect of continuous phorbol ester treatment on muscarinic receptor-mediated calmodulin redistribution in SK-N-SH neuroblastoma cells.
Neuroblastoma
Effect of palmitoylcarnitine on the cellular differentiation, proliferation and protein kinase C activity in neuroblastoma nb-2a cells.
Neuroblastoma
Effect of persistent measles virus infection on protein kinase C activity and c-fos protooncogene expression in neuroblastoma cells.
Neuroblastoma
Effect of protein kinase C inhibitors on the antiviral activity of human alpha interferon in herpes simplex virus-infected human neuroblastoma cells.
Neuroblastoma
Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts.
Neuroblastoma
Effects of retinoic acid and staurosporine on the protein kinase C activity and the morphology of two related human neuroblastoma cell lines.
Neuroblastoma
Enhancement of Ca2+ channel currents in human neuroblastoma (SH-SY5Y) cells by phorbol esters with and without activation of protein kinase C.
Neuroblastoma
Enhancement of neurite outgrowth following calpain inhibition is mediated by protein kinase C.
Neuroblastoma
Ethanol exposure potentiates fosB and junB expression induced by muscarinic receptor stimulation in neuroblastoma SH-SY5Y cells.
Neuroblastoma
Evaluation of ethanol effects on PLC signal transduction pathways using cell lines of neuronal origin.
Neuroblastoma
Evidence that the modulation of membrane-associated protein kinase C activity by an endogenous inhibitor plays a role in N1E-115 murine neuroblastoma cell differentiation.
Neuroblastoma
Expression of CD44 isoforms in neuroblastoma cells is regulated by PI 3-kinase and protein kinase C.
Neuroblastoma
Expression of MARCKS effector domain mutants alters phospholipase D activity and cytoskeletal morphology of SK-N-MC neuroblastoma cells.
Neuroblastoma
Expression of protein kinase C isoforms in euxanthone-induced differentiation of neuroblastoma cells.
Neuroblastoma
Expression of protein kinase C-alpha (PKC-alpha) and MYCN mRNAs in human neuroblastoma cells and modulation during morphological differentiation induced by retinoic acid.
Neuroblastoma
Extracellular signal-regulated kinase suppression is not involved in apoptosis of neuroblastoma N2a cells induced by protein kinase C inhibition.
Neuroblastoma
Functional corticotropin-releasing factor receptors in human neuroblastoma cells.
Neuroblastoma
Ginsenoside Re protects methamphetamine-induced mitochondrial burdens and proapoptosis via genetic inhibition of protein kinase C ? in human neuroblastoma dopaminergic SH-SY5Y cell lines.
Neuroblastoma
Growth inhibition and apoptosis in human neuroblastoma SK-N-SH cells induced by hypericin, a potent inhibitor of protein kinase C.
Neuroblastoma
H7, a protein kinase C inhibitor, increases the glutathione content of neuroblastoma cells.
Neuroblastoma
H7, an inhibitor of protein kinase C, prevents serum-induced phosphorylation of Raf and MAP kinase in neuroblastoma cells.
Neuroblastoma
Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.
Neuroblastoma
Identification of protein kinase C inhibitory activity associated with a polypeptide isolated from a phage display system with homology to PCM-1, the pericentriolar material-1 protein.
Neuroblastoma
Identification of PSF as a protein kinase Calpha-binding protein in the cell nucleus.
Neuroblastoma
In growth cones of rat cerebral neurons and human neuroblastoma cells, activation of protein kinase C causes a shift from filopodial to lamellipodial actin dynamics.
Neuroblastoma
Increased isoform-specific membrane translocation of conventional and novel protein kinase C in human neuroblastoma SH-SY5Y cells following prolonged hypoxia.
Neuroblastoma
Induction of neurites by the regulatory domains of PKCdelta and epsilon is counteracted by PKC catalytic activity and by the RhoA pathway.
Neuroblastoma
Inhibition of protein kinase C induces differentiation of neuroblastoma cells.
Neuroblastoma
Inhibitors of protein kinases induce differentiation in human neuroblastoma cell lines.
Neuroblastoma
Insulin-like growth factor I modulates voltage-dependent Ca2+ channels in neuronal cells.
Neuroblastoma
Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases.
Neuroblastoma
Interaction between phosphatidylserine biosynthesis and protein kinase C activation in neuroblastoma NB2a cells.
Neuroblastoma
Interaction of palmitoylcarnitine with protein kinase C in neuroblastoma NB-2a cells.
Neuroblastoma
Intracellular delivery of protein kinase C-alpha or -epsilon isoform-specific antibodies promotes acquisition of a morphologically differentiated phenotype in neuroblastoma cells.
Neuroblastoma
Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein.
Neuroblastoma
Involvement of diacylglycerol produced by phospholipase D activation in A?-induced reduction of sAPP? secretion in SH-SY5Y neuroblastoma cells.
Neuroblastoma
Involvement of multiple survival signal transduction pathways in the neuroprotective, neurorescue and APP processing activity of rasagiline and its propargyl moiety.
Neuroblastoma
Involvement of protein kinase C and E2F-5 in euxanthone-induced neurite differentiation of neuroblastoma.
Neuroblastoma
Local anaesthetics do not affect protein kinase C function in intact neuroblastoma cells.
Neuroblastoma
Long-term ethanol exposure impairs neuronal differentiation of human neuroblastoma cells involving neurotrophin-mediated intracellular signaling and in particular protein kinase C.
Neuroblastoma
micro-opioid-induced desensitization of opioid receptor-like 1 and micro-opioid receptors: differential intracellular signaling determines receptor sensitivity.
Neuroblastoma
Model experiments on squid axons and NG108-15 mouse neuroblastoma x rat glioma hybrid cells.
Neuroblastoma
Modulation of basal nitric oxide-dependent cyclic-GMP production by ambient glucose, myo-inositol, and protein kinase C in SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Modulation of neurite outgrowth in neuroblastoma cells by protein kinase C and platelet-activating factor.
Neuroblastoma
Modulation of protein kinase C and cAMP-dependent protein kinase by delta-opioid.
Neuroblastoma
Multiple effects of protein kinase C activators on Na+ currents in mouse neuroblastoma cells.
Neuroblastoma
Muscarinic receptor-linked elevation of cAMP in SH-SY5Y neuroblastoma cells is mediated by Ca2+ and protein kinase C.
Neuroblastoma
Muscarinic receptor-mediated increase in zeta-PKC expression in SK-N-SH human neuroblastoma cells.
Neuroblastoma
Muscarinic receptor-mediated induction of actin-driven lamellar protrusions in neuroblastoma cell somata and growth cones. Involvement of protein kinase C.
Neuroblastoma
N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells.
Neuroblastoma
N-myc disrupts protein kinase C-mediated signal transduction in neuroblastoma.
Neuroblastoma
N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization.
Neuroblastoma
Neuronal expression of a functional receptor for the C5a complement activation fragment.
Neuroblastoma
Nicergoline stimulates protein kinase C mediated alpha-secretase processing of the amyloid precursor protein in cultured human neuroblastoma SH-SY5Y cells.
Neuroblastoma
Novel and classical protein kinase C isoforms have different functions in proliferation, survival and differentiation of neuroblastoma cells.
Neuroblastoma
Nuclear localization of protein kinase C alpha and its association with nuclear components in neuro-2a neuroblastoma cells.
Neuroblastoma
Opposing influences of protein kinase activities on neurite outgrowth in human neuroblastoma cells: initiation by kinase A and restriction by kinase C.
Neuroblastoma
Overexpression of MARCKS, but not protein kinase C-alpha, increases phorbol ester-stimulated synthesis of phosphatidylcholine in human SK-N-MC neuroblastoma cells.
Neuroblastoma
Overexpression of myristoylated alanine-rich C-kinase substrate enhances activation of phospholipase D by protein kinase C in SK-N-MC human neuroblastoma cells.
Neuroblastoma
Palmitoylcarnitine affects localization of growth associated protein GAP-43 in plasma membrane subdomains and its interaction with G?(o) in neuroblastoma NB-2a cells.
Neuroblastoma
Palmitoylcarnitine modulates interaction between protein kinase C betaII and its receptor RACK1.
Neuroblastoma
Participation of type II protein kinase A in the retinoic acid-induced growth inhibition of SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Phorbol ester-enhanced noradrenaline secretion correlates with the presence and activity of protein kinase C-alpha in human SH-SY5Y neuroblastoma cells.
Neuroblastoma
Phosphatidic acid activation of protein kinase C in LA-N-1 neuroblastoma cells.
Neuroblastoma
Phosphatidylethanol biosynthesis in ethanol-exposed NG108-15 neuroblastoma X glioma hybrid cells. Evidence for activation of a phospholipase D phosphatidyl transferase activity by protein kinase C.
Neuroblastoma
Phospholipase D and phospholipase C in human cholinergic neuroblastoma (LA-N-2) cells: modulation by muscarinic agonists and protein kinase C.
Neuroblastoma
Phosphorylation and down-regulation of Bim by muscarinic cholinergic receptor activation via protein kinase C.
Neuroblastoma
Phosphorylation events mediated by protein kinase C alpha and epsilon participate in regulation of tau steady-state levels and generation of certain "Alzheimer-like" phospho-epitopes.
Neuroblastoma
Phosphorylation of endogenous proteins by adenosine 3':5'-monophosphate-dependent protein kinase in mouse neuroblastoma cells.
Neuroblastoma
PKC activity and PKC-alpha mRNA content are reduced in serum-derived human neuroblastoma cells without concomitant induction of differentiation.
Neuroblastoma
PKC delta and NADPH oxidase in retinoic acid-induced neuroblastoma cell differentiation.
Neuroblastoma
PKCepsilon, via its regulatory domain and independently of its catalytic domain, induces neurite-like processes in neuroblastoma cells.
Neuroblastoma
Pro-apoptotic protein kinase C delta is associated with intranuclear inclusions in a transgenic model of Huntington's disease.
Neuroblastoma
Protein kinase C activation and down-regulation in relation to phorbol ester-induced differentiation of SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Protein kinase C activation increases the rate and magnitude of agonist-induced delta-opioid receptor down-regulation in NG108-15 cells.
Neuroblastoma
Protein kinase C and its 80-kilodalton substrate protein in neuroblastoma cell neurite outgrowth.
Neuroblastoma
Protein kinase C beta1 is implicated in the regulation of neuroblastoma cell growth and proliferation.
Neuroblastoma
Protein kinase C inhibitors, H7 and calphostin C, inhibit induction of DNA synthesis by cytosolic extracts of exponentially growing neuroblastoma cells in isolated nuclei.
Neuroblastoma
Protein kinase C isoforms and growth, differentiation and phosphatidylcholine turnover in human neuroblastoma cells.
Neuroblastoma
Protein kinase C regulates bombesin-induced rapid VEGF secretion in neuroblastoma cells.
Neuroblastoma
Protein kinase C remains functionally active during TPA induced neuronal differentiation of SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Protein kinase C subtypes associated with the regulation of noradrenaline release in human SH-SY5Y neuroblastoma cells.
Neuroblastoma
Protein kinase C-alpha and -epsilon are enriched in growth cones of differentiating SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Protein kinase C-alpha but not protein kinase C-epsilon is differentially down-regulated by bryostatin 1 and tetradecanoyl phorbol 13-acetate in SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Protein kinase C-epsilon is implicated in neurite outgrowth in differentiating human neuroblastoma cells.
Neuroblastoma
Protein kinase Cepsilon binds peripherin and induces its aggregation, which is accompanied by apoptosis of neuroblastoma cells.
Neuroblastoma
Receptor regulation of the volume-sensitive efflux of taurine and iodide from human SH-SY5Y neuroblastoma cells: differential requirements for Ca(2+) and protein kinase C.
Neuroblastoma
Redistribution of F-actin and large dense-cored vesicles in the human neuroblastoma SH-SY5Y in response to secretagogues and protein kinase Calpha activation.
Neuroblastoma
Regulation of mu opioid receptor mRNA levels by activation of protein kinase C in human SH-SY5Y neuroblastoma cells.
Neuroblastoma
Regulation of N-acetylaspartate and N-acetylaspartylglutamate biosynthesis by protein kinase activators.
Neuroblastoma
Regulation of neurite outgrowth through protein kinase C and protease nexin-1 in neuroblastoma cell.
Neuroblastoma
Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo.
Neuroblastoma
Reversible structural alterations of undifferentiated and differentiated human neuroblastoma cells induced by phorbol ester.
Neuroblastoma
Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: I. PKC translocation to the membrane of SH-SY5Y neuroblastoma cells is induced by mu-opioid agonists.
Neuroblastoma
Role of protein kinase C and mitochondrial permeability transition pore in the neuroprotective effect of ceramide in ischemia-induced cell death.
Neuroblastoma
Role of protein kinase Calpha in the regulated secretion of the amyloid precursor protein.
Neuroblastoma
Selective activation of protein kinase C isoforms by angiotensin II in neuroblastoma X glioma cells.
Neuroblastoma
Silencing the ACAT1 Gene in Human SH-SY5Y Neuroblastoma Cells Inhibits the Expression of Cyclo-Oxygenase 2 (COX2) and Reduces ?-Amyloid-Induced Toxicity Due to Activation of Protein Kinase C (PKC) and ERK.
Neuroblastoma
Staurosporine-induced morphological differentiation of human neuroblastoma cells.
Neuroblastoma
Suramin, an anti-cancer drug, inhibits protein kinase C and induces differentiation in neuroblastoma cell clone NB2A.
Neuroblastoma
The catalytic domain limits the translocation of protein kinase C alpha in response to increases in Ca2+ and diacylglycerol.
Neuroblastoma
The effect of down-regulation and long-term inhibition of protein kinase C on noradrenaline secretion in the neuroblastoma cell line SH-SY5Y.
Neuroblastoma
The effect of protein kinase C activation on muscarinic-M3- and K(+)-evoked release of [3H]noradrenaline and increases in intracellular Ca2+ in human neuroblastoma SH-SY5Y cells.
Neuroblastoma
The essentiality of Bcl-2, PKC and proteasome-ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline.
Neuroblastoma
The involvement of VEGF receptors and MAPK in the cannabinoid potentiation of Ca2+ flux into N18TG2 neuroblastoma cells.
Neuroblastoma
The protein kinase C activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), inhibits muscarinic (M1) receptor-mediated inositol phosphate release and cyclic GMP formation in murine neuroblastoma cells (clone N1E-115).
Neuroblastoma
The regulatory domain of protein kinase Ctheta localises to the Golgi complex and induces apoptosis in neuroblastoma and Jurkat cells.
Neuroblastoma
The role of protein kinase C alpha in tri-ortho-cresyl phosphate-induced autophagy in human neuroblastoma SK-N-SH cells.
Neuroblastoma
The role of protein kinase C in inducing Alzheimer's A68 protein expression in the culture of human neuroblastoma cells.
Neuroblastoma
The selective protein kinase C inhibitor GF 109203X inhibits phorbol ester-induced morphological and functional differentiation of SH-SY5Y human neuroblastoma cells.
Neuroblastoma
The specific inhibitor of protein kinase C, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7), induces morphological change and cell differentiation of human neural crest-derived cell lineages.
Neuroblastoma
The study of clostridial and related toxins. The search for unique mechanisms and common denominators.
Neuroblastoma
The thiol proteinase inhibitor E-64-d ameliorates amyloid-?-induced reduction of sAPP? secretion by reversing ceramide-induced protein kinase C down-regulation in SH-SY5Y neuroblastoma cells.
Neuroblastoma
TRAIL resistance in human neuroblastoma SK-N-AS cells is dependent on protein kinase C and involves inhibition of caspase-3 proteolytic processing.
Neuroblastoma
Transglutaminase 2 and NF-kappaB interplay during NGF-induced differentiation of neuroblastoma cells.
Neuroblastoma
Uridine induces differentiation in human neuroblastoma cells via protein kinase C epsilon.
Neuroblastoma
Vasoactive intestinal polypeptide stimulates cyclic AMP production in mouse N1E-115 neuroblastoma cells: modulation by a protein kinase C activator and ionomycin.
Neuroblastoma
Whole-cell recording of neuroblastoma x glioma cells during downregulation of a major substrate, 80K/MARCKS, of protein kinase C.
Neuroblastoma
[The stimulation of glutamate uptake by the phorbol ester in rat cerebral cortex synaptosomes and cell line of human anaplastic astrocytoma BT-325]
Neurodegenerative Diseases
Adeno-associated virus vector-mediated expression of DJ-1 attenuates learning and memory deficits in 2, 2´, 4, 4´-tetrabromodiphenyl ether (BDE-47)-treated mice.
Neurodegenerative Diseases
Age does not alter Protein kinase C isozymes mRNA expression in rat brain.
Neurodegenerative Diseases
Aggregate formation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14 impairs ubiquitin-proteasome system and induces endoplasmic reticulum stress.
Neurodegenerative Diseases
Atypical protein kinase C expression in phrenic motor neurons of the rat.
Neurodegenerative Diseases
Atypical protein kinase C in neurodegenerative disease I: PKMzeta aggregates with limbic neurofibrillary tangles and AMPA receptors in Alzheimer disease.
Neurodegenerative Diseases
Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies.
Neurodegenerative Diseases
Diverse Biological Functions of Sphingolipids in the CNS: Ceramide and Sphingosine Regulate Myelination in Developing Brain but Stimulate Demyelination during Pathogenesis of Multiple Sclerosis.
Neurodegenerative Diseases
Drug Development for Neurodegenerative Diseases--Second Annual marcus evans Conference. Advances in drug development for NDD and expediting discovery through novel compounds and sound clinical trials.
Neurodegenerative Diseases
Identification and characterization of PKC?, a kinase associated with SCA14, as an amyloidogenic protein.
Neurodegenerative Diseases
Increased phospho-adducin immunoreactivity in a murine model of amyotrophic lateral sclerosis.
Neurodegenerative Diseases
Molecular pathophysiology of neurodegenerative disease caused by ?PKC mutations.
Neurodegenerative Diseases
PKC gamma mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling.
Neurodegenerative Diseases
Protection from ataxia-linked apoptosis by gap junction inhibitors.
Neurodegenerative Diseases
Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila.
Neurodegenerative Diseases
Protein Interacting with C-Kinase 1 Deficiency Impairs Glutathione Synthesis and Increases Oxidative Stress via Reduction of Surface Excitatory Amino Acid Carrier 1.
Neurodegenerative Diseases
Protein kinase C is involved in the neuroprotective effect of berberine against intrastriatal injection of quinolinic acid-induced biochemical alteration in mice.
Neurodegenerative Diseases
Protein Kinase C Isozymes and Autophagy during Neurodegenerative Disease Progression.
Neurodegenerative Diseases
Reduced Purkinje cell size is compatible with near normal morphology and function of the cerebellar cortex in a mouse model of spinocerebellar ataxia.
Neurodegenerative Diseases
Role of PKC-delta activity in glutathione-depleted neuroblastoma cells.
Neurodegenerative Diseases
Scallop-derived plasmalogens attenuate the activation of PKC? associated with the brain inflammation.
Neurodegenerative Diseases
Small interfering RNA-mediated knockdown of protein kinase C zeta attenuates domoic acid-induced cognitive deficits in mice.
Neurodegenerative Diseases
Small-molecule drug screening identifies drug Ro 31-8220 that reduces toxic phosphorylated tau in Drosophila melanogaster.
Neurodegenerative Diseases
Survival-promoting and protein kinase C-regulating roles of basic FGF for hippocampal neurons exposed to phorbol ester, glutamate and ischaemia-like conditions.
Neurodegenerative Diseases
Synthesis and Pharmacological Evaluation of 8- and 9-Substituted Benzolactam-V8 Derivatives as Potent Ligands for Protein Kinase C, a Therapeutic Target for Alzheimer's Disease.
Neurodegenerative Diseases
The PKC-? interacting protein ZIP3 is generated by intronic polyadenylation and is expressed in brain and retina of the rat.
Neurogenic Inflammation
Increases in transient receptor potential vanilloid-1 mRNA and protein in primary afferent neurons stimulated by protein kinase C and their possible role in neurogenic inflammation.
Neuroinflammatory Diseases
A proteomic analysis of PKCepsilon targets in astrocytes: implications for astrogliosis.
Neuroinflammatory Diseases
Caruifolin D from artemisia absinthium L. inhibits neuroinflammation via reactive oxygen species-dependent c-jun N-terminal kinase and protein kinase c/NF-?B signaling pathways.
Neuroinflammatory Diseases
Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammation.
Neuroinflammatory Diseases
Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo.
Neuroinflammatory Diseases
Neuroinflammation and oxidative stress in diabetic neuropathy: futuristic strategies based on these targets.
Neuroinflammatory Diseases
PKCepsilon induces astrocyte stellation by modulating multiple cytoskeletal proteins and interacting with Rho A signalling pathways: implications for neuroinflammation.
Neuroinflammatory Diseases
Scallop-derived plasmalogens attenuate the activation of PKC? associated with the brain inflammation.
Neuroinflammatory Diseases
Suppression of PKC-? attenuates TNF-?-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen-plasmin system.
Neurologic Manifestations
Mice deficient in PKC theta demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases.
Nevus
Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases.
Non-alcoholic Fatty Liver Disease
Considering the Links Between Nonalcoholic Fatty Liver Disease and Insulin Resistance: Revisiting the Role of Protein Kinase C ?.
Non-alcoholic Fatty Liver Disease
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Non-alcoholic Fatty Liver Disease
Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosis.
Non-alcoholic Fatty Liver Disease
Lipid metabolism, oxidative stress and cell death are regulated by PKC delta in a dietary model of nonalcoholic steatohepatitis.
Non-alcoholic Fatty Liver Disease
Mechanisms of Disease: hepatic steatosis in type 2 diabetes--pathogenesis and clinical relevance.
Non-alcoholic Fatty Liver Disease
Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction.
Non-alcoholic Fatty Liver Disease
PKC? silencing alleviates saturated fatty acid induced ER stress by enhancing SERCA activity.
Non-alcoholic Fatty Liver Disease
PKCepsilon plays a causal role in acute ethanol-induced steatosis.
Non-alcoholic Fatty Liver Disease
Roles of Autophagy and Protein Kinase C-epsilon in Lipid Metabolism of Nonalcoholic Fatty Liver Cell Models.
Obesity
BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1? in livers of obese and type 2 diabetic humans.
Obesity
Chaperoning to the metabolic party: The emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes.
Obesity
Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans.
Obesity
Critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappa B in obesity.
Obesity
Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3,4,5,-(PO(4))(3) in Obesity and Polycystic Ovary Syndrome.
Obesity
Deletion of Protein Kinase C ? in POMC Neurons Predisposes to Diet-Induced Obesity.
Obesity
Disruption of the murine protein kinase Cbeta gene promotes gallstone formation and alters biliary lipid and hepatic cholesterol metabolism.
Obesity
Effects of obesity on protein kinase C, brain creatine kinase, transcription, and autophagy in cochlea.
Obesity
Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus.
Obesity
Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.
Obesity
Impaired glucose metabolism in the heart of obese Zucker rats after treatment with phorbol ester.
Obesity
Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice.
Obesity
Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes.
Obesity
Insulin-stimulated glucose transport in muscle. Evidence for a protein-kinase-C-dependent component which is unaltered in insulin-resistant mice.
Obesity
Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction.
Obesity
Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity.
Obesity
Is insulin resistance in the spontaneously hypertensive rat related to changes in protein kinase C in skeletal muscle?
Obesity
Loss of protein kinase Cbeta function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance.
Obesity
Mechanistic insight into high-fat diet-induced metabolic inflammation in the arcuate nucleus of the hypothalamus.
Obesity
Obesity is associated with impaired ventricular protein kinase C-MAP kinase signaling and altered ANP mRNA expression in the heart of adult Zucker rats.
Obesity
Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies.
Obesity
Oxidative stress in cardiovascular diseases and obesity: role of p66Shc and protein kinase C.
Obesity
Protein kinase betaII in Zucker obese rats compromises oxygen and flow-mediated regulation of nitric oxide formation.
Obesity
Protein kinase C deficiency increases fatty acid oxidation and reduces fat storage.
Obesity
Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states.
Obesity
Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.
Obesity
Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteries.
Obesity
Reduced Placental Taurine Transporter (TauT) Activity in Pregnancies Complicated by Pre-eclampsia and Maternal Obesity.
Obesity
Role of adipose and hepatic atypical protein kinase C lambda (PKC?) in the development of obesity and glucose intolerance.
Olivopontocerebellar Atrophies
Inositol 1,4,5-trisphosphate receptors and protein kinase C in olivopontocerebellar atrophy.
Osteoarthritis
Cyclic tensile stretch on bovine articular chondrocytes inhibits protein kinase C activity.
Osteoarthritis
Divergent effects of infliximab and anakinra therapies on macrophage phenotype from patients with refractory rheumatoid arthritis.
Osteoarthritis
Protein kinase C activator inhibits progression of osteoarthritis induced in rabbit knee joints.
Osteoarthritis
Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes.
Osteoarthritis
Quantitative immunodetection of key elements of polyphosphoinositide signal transduction in osteoblasts from arthritic patients shows a direct correlation with cell proliferation.
Osteoporosis
Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage.
Osteosarcoma
1,25-Dihydroxyvitamin D3 selectively translocates PKCalpha to nuclei in ROS 17/2.8 cells.
Osteosarcoma
A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C.
Osteosarcoma
Cadmium perturbs calcium homeostasis in rat osteosarcoma (ROS 17/2.8) cells; a possible role for protein kinase C.
Osteosarcoma
CXCL13/CXCR5 Interaction Facilitates VCAM-1-Dependent Migration in Human Osteosarcoma.
Osteosarcoma
Effect of modulation of protein kinase C activity on cisplatin cytotoxicity in cisplatin-resistant and cisplatin-sensitive human osteosarcoma cells.
Osteosarcoma
Evidence for increased synthesis as well as increased degradation of protein kinase C after treatment of human osteosarcoma cells with phorbol ester.
Osteosarcoma
Gene expression changes in BALB/3T3 transformants induced by poly(L-lactic acid) or polyurethane films.
Osteosarcoma
Inhibition of PKCalpha activation in human bone and soft tissue sarcoma cells by the selective PKC inhibitor PKC412.
Osteosarcoma
Parathyroid hormone causes translocation of protein kinase-C from cytosol to membranes in rat osteosarcoma cells.
Osteosarcoma
Parathyroid hormone fragment [3-34] stimulates protein kinase C (PKC) activity in rat osteosarcoma and murine T-lymphoma cells.
Osteosarcoma
Parathyroid hormone stimulates translocation of protein kinase C isozymes in UMR-106 osteoblastic osteosarcoma cells.
Osteosarcoma
Phorbol 12-myristate 13-acetate and 1,25-dihydroxyvitamin D3 regulate 1,25-dihydroxyvitamin D3 receptors synergistically in rat osteosarcoma cells.
Osteosarcoma
Platelet-derived growth factor-stimulated c-myc RNA accumulation in MG-63 human osteosarcoma cells is independent of both protein kinase A and protein kinase C.
Osteosarcoma
Possible involvement of protein kinase C in parathyroid hormone degradation by osteoblast-like rat osteosarcoma cell line UMR106.
Osteosarcoma
Prostaglandin-induced changes in calcium uptake and cAMP production in osteoblast-like cells: role of protein kinase C.
Osteosarcoma
Protein kinase C activating phorbolesters enhance the cyclic AMP response to parathyroid hormone, forskolin and choleratoxin in mouse calvarial bones and rat osteosarcoma cells.
Osteosarcoma
Protein kinase C differentially modulates PTH- and PGE2-sensitive adenylate cyclase in osteoblast-like cells.
Osteosarcoma
Protein kinase C is involved in PTH-induced homologous desensitization by directly affecting PTH receptor in the osteoblastic osteosarcoma cells.
Osteosarcoma
Protein kinase C modulates parathyroid hormone- but not prostaglandin E2-mediated stimulation of cyclic AMP production via the inhibitory guanine nucleotide binding protein in UMR-106 osteosarcoma cells.
Osteosarcoma
Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells.
Osteosarcoma
Regulation of expression and activity of four PKC isozymes in confluent and mechanically stimulated UMR-108 osteoblastic cells.
Osteosarcoma
Regulation of the TNF-alpha receptor in human osteosarcoma cells: role of microtubules and of protein kinase C.
Osteosarcoma
Single-nucleotide polymorphisms of the PRKCG gene and osteosarcoma susceptibility.
Osteosarcoma
Stimulation of membrane-associated protein kinase-C activity in spleen lymphocytes by hPTH-(1-31)NH2, its lactam derivative, [Leu27]-cyclo(Glu22-Lys26)-hPTH-(1-31)NH2, and hPTH-(1-30)NH2.
Osteosarcoma
Structure and protein kinase C stimulating activities of lactam analogues of human parathyroid hormone fragment.
Osteosarcoma
Sulfhydryl modification by 4,4'-dithiodipyridine induces calcium mobilization in human osteoblast-like cells.
Osteosarcoma
The effect of cadmium on cytosolic free calcium, protein kinase C, and collagen synthesis in rat osteosarcoma (ROS 17/2.8) cells.
Osteosarcoma
Thiol oxidation by 2,2'-dithiodipyridine induced calcium mobilization in MG63 human osteosarcoma cells.
Osteosarcoma
Time-dependent changes in protein kinase C distribution and disappearance in phorbol ester-treated human osteosarcoma cells.
Osteosarcoma
Type-1 parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptors activate phospholipase C in response to carboxyl-truncated analogs of PTH(1-34).
Osteosarcoma
Vinblastine-dependent down-modulation of TNF receptors in human osteosarcoma cells is mediated by protein kinase C activity.
Ototoxicity
The role of PKCzeta in amikacin-induced apoptosis in the cochlea: prevention by aspirin.
Ovarian Neoplasms
A Mixed-Methods Feasibility Trial of Protein Kinase C Iota Inhibition with Auranofin in Asymptomatic Ovarian Cancer Patients.
Ovarian Neoplasms
Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.
Ovarian Neoplasms
Atypical protein kinase C zeta exhibits a proapoptotic function in ovarian cancer.
Ovarian Neoplasms
Atypical protein kinase C zeta: potential player in cell survival and cell migration of ovarian cancer.
Ovarian Neoplasms
Crystal structures of PRK1 in complex with the clinical compounds lestaurtinib and tofacitinib reveal ligand induced conformational changes.
Ovarian Neoplasms
Evaluating the current status of protein kinase C (PKC)-protein kinase D (PKD) signalling axis as a novel therapeutic target in ovarian cancer.
Ovarian Neoplasms
Expression analysis of protein kinase C isozymes and multidrug resistance associated genes in ovarian cancer cells.
Ovarian Neoplasms
Gemcitabine induces programmed cell death and activates protein kinase C in BG-1 human ovarian cancer cells.
Ovarian Neoplasms
Induction of drug resistance and protein kinase C genes in A2780 ovarian cancer cells after incubation with antineoplastic agents at sublethal concentrations.
Ovarian Neoplasms
Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma.
Ovarian Neoplasms
KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha.
Ovarian Neoplasms
Mechanism of gonadotropin-releasing hormone (GnRH)-I and -II-induced cell growth inhibition in ovarian cancer cells: role of the GnRH-I receptor and protein kinase C pathway.
Ovarian Neoplasms
Modulation of drug resistance in ovarian cancer cells by inhibition of protein kinase C-alpha (PKC-?) with small interference RNA (siRNA) agents.
Ovarian Neoplasms
Multiple gene expression analysis reveals distinct differences between G2 and G3 stage breast cancers, and correlations of PKC eta with MDR1, MRP and LRP gene expression.
Ovarian Neoplasms
Phase II trial of bryostatin-1 in combination with cisplatin in patients with recurrent or persistent epithelial ovarian cancer: a California cancer consortium study.
Ovarian Neoplasms
Phosphorylation of claudin-4 by PKCepsilon regulates tight junction barrier function in ovarian cancer cells.
Ovarian Neoplasms
PKCiota promotes ovarian tumor progression through deregulation of cyclin E.
Ovarian Neoplasms
Protein interacting with C alpha kinase 1 (PICK1) is involved in promoting tumor growth and correlates with poor prognosis of human breast cancer.
Ovarian Neoplasms
Protein kinase C alpha-CARMA3 signaling axis links Ras to NF-kappa B for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells.
Ovarian Neoplasms
Protein kinase C inhibitor Gö6976 augments caffeine-induced reversal of chemoresistance to cis-diamminedichloroplatinum-II (CDDP) in a human ovarian cancer model.
Ovarian Neoplasms
Receptor interacting protein kinase 4 promotes cell proliferation, migration, and invasion in ovarian cancer via targeting protein kinase C delta.
Ovarian Neoplasms
Role of mitogen-activated protein kinase/extracellular signal-regulated kinase cascade in gonadotropin-releasing hormone-induced growth inhibition of a human ovarian cancer cell line.
Ovarian Neoplasms
Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance.
Ovarian Neoplasms
The effect of protein kinase C inhibitors on invasion of human ovary cancer cells.
Ovarian Neoplasms
The role of protein kinase C and the phosphatidylinositol cycle in multidrug resistance in human ovarian cancer cells.
Ovarian Neoplasms
[Expression of connexin 43 in ovarian cancer and its relationship with chemoresistance]
Pancreatic Diseases
Protein kinase C isoforms in the normal pancreas and in pancreatic disease.
Pancreatic Neoplasms
A protein kinase C inhibitor induces phenotypic reversion of ras-transformed pancreatic cancer cells and cooperatively blocks tumor cell proliferation with an anti- ras peptide.
Pancreatic Neoplasms
A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion.
Pancreatic Neoplasms
Activation of protein kinase Calpha inhibits growth of pancreatic cancer cells via p21(cip)-mediated G(1) arrest.
Pancreatic Neoplasms
Cholecystokinin regulates the invasiveness of human pancreatic cancer cell lines via protein kinase C pathway.
Pancreatic Neoplasms
Dietary energy restriction-induced modulation of protein kinase C zeta isozyme in the hamster pancreas.
Pancreatic Neoplasms
Directed antisense therapy confirms the role of protein kinase C-alpha in the tumorigenicity of pancreatic cancer.
Pancreatic Neoplasms
Enzastaurin, an inhibitor of PKCbeta, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells.
Pancreatic Neoplasms
Expression patterns of protein kinase C isoenzymes are characteristically modulated in chronic pancreatitis and pancreatic cancer.
Pancreatic Neoplasms
Inhibition of protein kinase Cbeta by enzastaurin enhances radiation cytotoxicity in pancreatic cancer.
Pancreatic Neoplasms
K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling.
Pancreatic Neoplasms
Mu-KRAS attenuates Hippo signaling pathway through PKC? to sustain the growth of pancreatic cancer.
Pancreatic Neoplasms
Multiple signal pathways are involved in the mitogenic effect of 5(S)-HETE in human pancreatic cancer.
Pancreatic Neoplasms
Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1.
Pancreatic Neoplasms
Nicotine enhances the malignant potential of human pancreatic cancer cells via activation of atypical protein kinase C.
Pancreatic Neoplasms
Norepinephrine inhibits the migratory activity of pancreatic cancer cells.
Pancreatic Neoplasms
Phase I dose escalation study of the PKC? inhibitor aurothiomalate for advanced non-small-cell lung cancer, ovarian cancer, and pancreatic cancer.
Pancreatic Neoplasms
PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer.
Pancreatic Neoplasms
PKC delta and tissue transglutaminase are novel inhibitors of autophagy in pancreatic cancer cells.
Pancreatic Neoplasms
PKCalpha-induced drug resistance in pancreatic cancer cells is associated with transforming growth factor-beta1.
Pancreatic Neoplasms
Protein Kinase C Iota Regulates Pancreatic Acinar-to-Ductal Metaplasia.
Pancreatic Neoplasms
Protein Kinase C Zeta Regulates Human Pancreatic Cancer Cell Transformed Growth and Invasion through a STAT3-Dependent Mechanism.
Pancreatic Neoplasms
Protein kinase C? inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4.
Pancreatic Neoplasms
Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis.
Pancreatic Neoplasms
Role of insulin receptor substrates and protein kinase C-zeta in vascular permeability factor/vascular endothelial growth factor expression in pancreatic cancer cells.
Pancreatic Neoplasms
Tamoxifen enhances the anticancer effect of cantharidin and norcantharidin in pancreatic cancer cell lines through inhibition of the protein kinase C signaling pathway.
Pancreatic Neoplasms
Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer.
Pancreatic Neoplasms
Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA-methylation in human pancreatic cancer cells.
Pancreatitis
A NOVEL PROTEIN KINASE D INHIBITOR ATTENUATES EARLY EVENTS OF EXPERIMENTAL PANCREATITIS IN ISOLATED RAT ACINI.
Pancreatitis
Alcohol-induced protein kinase Calpha phosphorylation of Munc18c in carbachol-stimulated acini causes basolateral exocytosis.
Pancreatitis
Deletion of toll-like receptor-4 downregulates protein kinase C-zeta and attenuates liver injury in experimental pancreatitis.
Pancreatitis
Hyperlipidemia intensifies cerulein-induced acute pancreatitis associated with activation of protein kinase C in rats.
Pancreatitis
Protein kinase C modulates the pulmonary inflammatory response in acute pancreatitis.
Pancreatitis
Protein kinase C-zeta is critical in pancreatitis-induced apoptosis of Kupffer cells.
Pancreatitis
Restoration of spontaneous exploratory behaviors with an intrathecal NMDA receptor antagonist or a PKC inhibitor in rats with acute pancreatitis.
Pancreatitis
The novel protein kinase C isoforms -delta and -epsilon modulate caerulein-induced zymogen activation in pancreatic acinar cells.
Pancreatitis
Tumor necrosis factor-alpha mediates pancreatitis responses in acinar cells via protein kinase C and proline-rich tyrosine kinase 2.
Pancreatitis, Chronic
Expression patterns of protein kinase C isoenzymes are characteristically modulated in chronic pancreatitis and pancreatic cancer.
Pancreatitis, Chronic
Human pancreatic adenocarcinoma-associated antigens defined by novel murine monoclonal antibodies Pak-1 and Pak-2.
Papilloma
A role for protein kinase C-delta in the regulation of ornithine decarboxylase expression by oxidative stress.
Papilloma
Alterations in protein kinase C isozymes alpha and beta 2 in activated Ha-ras containing papillomas in the absence of an increase in diacylglycerol.
Papilloma
Characterization of benzo[a]pyrene-initiated mouse skin papillomas for Ha-ras mutations and protein kinase C levels.
Papilloma
Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice.
Papilloma
Focal transgene expression associated with papilloma development in v-Ha-ras-transgenic TG.AC mice.
Papilloma
Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor-promotion susceptibilities of protein kinase C alpha, -delta and -epsilon transgenic mice.
Papilloma
Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.
Paralysis
Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies.
Paralysis
On the possible origin of giant or slow-rising miniature end-plate potentials at the neuromuscular junction.
Paramyxoviridae Infections
Cellular protein kinase C isoform zeta regulates human parainfluenza virus type 3 replication.
Paramyxoviridae Infections
Differential phosphorylation of the nucleoprotein of influenza A viruses.
Paramyxoviridae Infections
Human parainfluenza virus type 3 phosphoprotein: identification of serine 333 as the major site for PKC zeta phosphorylation.
Paramyxoviridae Infections
Phosphorylation of Sendai virus phosphoprotein by cellular protein kinase C zeta.
Paraneoplastic Cerebellar Degeneration
General assay for phosphoproteins in cerebrospinal fluid: a candidate marker for paraneoplastic cerebellar degeneration.
Parasitic Diseases
Molecular cloning, cell localization and binding affinity to DNA replication proteins of the p36/LACK protective antigen from Leishmania infantum.
Parathyroid Neoplasms
Primary hyperparathyroidism: role of the preoperative oral calcium loading test in the differential diagnosis between adenoma and hyperplasia.
Parkinson Disease
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Parkinson Disease
A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models.
Parkinson Disease
Alteration of protein kinase C conformation in red blood cells: a potential marker for Alzheimer's disease but not for Parkinson's disease.
Parkinson Disease
Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies.
Parkinson Disease
Diverse Biological Functions of Sphingolipids in the CNS: Ceramide and Sphingosine Regulate Myelination in Developing Brain but Stimulate Demyelination during Pathogenesis of Multiple Sclerosis.
Parkinson Disease
Drug Development for Neurodegenerative Diseases--Second Annual marcus evans Conference. Advances in drug development for NDD and expediting discovery through novel compounds and sound clinical trials.
Parkinson Disease
Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease.
Parkinson Disease
Integrative Analysis of Gene Expression and Regulatory Network Interaction Data Reveals the Protein Kinase C Family of Serine/Threonine Receptors as a Significant Druggable Target for Parkinson's Disease.
Parkinson Disease
Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases.
Parkinson Disease
Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.
Parkinson Disease
Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels.
Parkinson Disease
Protein Interacting with C-Kinase 1 Deficiency Impairs Glutathione Synthesis and Increases Oxidative Stress via Reduction of Surface Excitatory Amino Acid Carrier 1.
Parkinson Disease
Rottlerin protected dopaminergic cell line from cytotoxicity of 6-hydroxydopamine by inhibiting PKCdelta phosphorylation.
Parkinson Disease
Second messenger systems in brains of patients with Parkinson's or Huntington's disease.
Parkinson Disease
Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells.
Parkinsonian Disorders
PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway.
Parvoviridae Infections
Novel PKCeta is required to activate replicative functions of the major nonstructural protein NS1 of minute virus of mice.
Parvoviridae Infections
Parvovirus interference with intracellular signalling: mechanism of PKCeta activation in MVM-infected A9 fibroblasts.
Pemphigoid, Bullous
Macropinocytosis of type XVII collagen induced by bullous pemphigoid IgG is regulated via protein kinase C.
Pemphigoid, Bullous
Transient translocation of hemidesmosomal bullous pemphigoid antigen 1 from cytosol to membrane fractions by 12-O-tetradecanoylphorbol-13-acetate treatment and Ca2+-switch in a human carcinoma cell line.
Pemphigus
Beyond steric hindrance: the role of adhesion signaling pathways in the pathogenesis of pemphigus.
Pemphigus
Differential coupling of M1 muscarinic and alpha7 nicotinic receptors to inhibition of pemphigus acantholysis.
Pemphigus
Pemphigus IgG activates and translocates protein kinase C from the cytosol to the particulate/cytoskeleton fractions in human keratinocytes.
Pemphigus
Phosphatidylcholine-specific phospholipase C, but not phospholipase D, is involved in pemphigus IgG-induced signal transduction.
Pemphigus
Transmembrane signaling for adhesive regulation of desmosomes and hemidesmosomes, and for cell-cell datachment induced by pemphigus IgG in cultured keratinocytes: involvement of protein kinase C.
Periodontal Diseases
Defective calcium influx factor activity in neutrophils from patients with localized juvenile periodontitis.
Periodontitis
Chemoluminescence generation and MTT dye reduction by polymorphonuclear leukocytes from periodontal disease patients.
Periodontitis
Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: association with periodontitis.
Peripheral Nerve Injuries
Mechanism of diabetic neuropathy: Where are we now and where to go?
Peripheral Nerve Injuries
Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain.
Peripheral Nerve Injuries
Neurochemical characterization of neuronal populations expressing protein kinase C gamma isoform in the spinal cord and gracile nucleus of the rat.
Peripheral Nerve Injuries
Pain behaviors after spinal cord contusion injury in two commonly used mouse strains.
Peripheral Nerve Injuries
Pain-related increases in spinal cord membrane-bound protein kinase C following peripheral nerve injury.
Peripheral Nerve Injuries
Peripheral nerve injury induces trans-synaptic modification of channels, receptors and signal pathways in rat dorsal spinal cord.
Peripheral Nerve Injuries
Specific involvement in neuropathic pain of AMPA receptors and adapter proteins for the GluR2 subunit.
Peripheral Nerve Injuries
The types of neuron which contain protein kinase C gamma in rat spinal cord.
Peripheral Nervous System Diseases
A 6-month, randomized, double-masked, placebo-controlled study evaluating the effects of the protein kinase C-beta inhibitor ruboxistaurin on skin microvascular blood flow and other measures of diabetic peripheral neuropathy.
Peripheral Nervous System Diseases
Activating transcription factor 3 modulates protein kinase C epsilon activation in diabetic peripheral neuropathy.
Peripheral Nervous System Diseases
Endothelial and neural regulation of skin microvascular blood flow in patients with diabetic peripheral neuropathy: effect of treatment with the isoform-specific protein kinase C beta inhibitor, ruboxistaurin.
Peripheral Nervous System Diseases
Identifying the Role of Novel Protein Kinase C Isoforms in Mediating Paclitaxel-Induced Peripheral Neuropathy.
Peripheral Nervous System Diseases
Interactions between and Shared Molecular Mechanisms of Diabetic Peripheral Neuropathy and Obstructive Sleep Apnea in Type 2 Diabetes Patients.
Peripheral Nervous System Diseases
Myelin protein zero/P0 phosphorylation and function require an adaptor protein linking it to RACK1 and PKC alpha.
Peripheral Nervous System Diseases
Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat.
Peripheral Nervous System Diseases
Protein kinase C beta inhibitor prevents diabetic peripheral neuropathy, but not histopathological abnormalities of retina in Spontaneously Diabetic Torii rat.
Peripheral Nervous System Diseases
Sexual dimorphism for protein kinase c epsilon signaling in a rat model of vincristine-induced painful peripheral neuropathy.
Peripheral Nervous System Diseases
Treatment for diabetic peripheral neuropathy: What have we learned from animal models?
Peripheral Nervous System Diseases
Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial.
Peripheral Nervous System Diseases
[Survey of current experimental studies of effects of traditional Chinese compound recipe on diabetic peripheral neuropathy]
Pheochromocytoma
Activation of soluble guanylate cyclase through phosphorylation by protein kinase C in intact PC12 cells.
Pheochromocytoma
Activation of UDP-galactose:globotriaosylceramide alpha 1-3-galactosyltransferase during PC12D cell differentiation induced by galactosylceramide.
Pheochromocytoma
Calcium/phospholipid-dependent protein kinase (protein kinase C) phosphorylates and activates tyrosine hydroxylase.
Pheochromocytoma
Changes of nuclear protein kinase C activity and isotype composition in PC12 cell proliferation and differentiation.
Pheochromocytoma
Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells.
Pheochromocytoma
Delta-protein kinase C phosphorylation parallels inhibition of nerve growth factor-induced differentiation independent of changes in Trk A and MAP kinase signalling in PC12 cells.
Pheochromocytoma
Differential Effects of Glycosphingolipids n Protein Kinase C Activity in PC12D Pheochromocytoma Cells.
Pheochromocytoma
Differential modulation of pharmacologically distinct components of Ca2+ currents by protein kinase C activators and phosphatase inhibitors in nerve-growth-factor-differentiated rat pheochromocytoma (PC12) cells.
Pheochromocytoma
Distinct protein kinase C isoforms mediate regulation of vascular endothelial growth factor expression by A2A adenosine receptor activation and phorbol esters in pheochromocytoma PC12 cells.
Pheochromocytoma
Effects of protein kinase C and A activation on ATP-stimulated release of [3H]noradrenaline from PC12 cells.
Pheochromocytoma
Expression of tyrosine hydroxylase gene in cultured hypothalamic cells: roles of protein kinase A and C.
Pheochromocytoma
Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis.
Pheochromocytoma
Genistein inhibits Ca2+ influx by extracellular ATP in PC12 pheochromocytoma cells.
Pheochromocytoma
Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase.
Pheochromocytoma
Inhibition by protein kinase C activation of melittin-induced arachidonic acid release in PC12 pheochromocytoma cells.
Pheochromocytoma
Modulation of delayed rectifier potassium channel by protein kinase C zeta-containing signaling complex in pheochromocytoma cells.
Pheochromocytoma
Natriuretic peptides suppress protein kinase C activity to reduce evoked dopamine efflux from pheochromocytoma (PC12) cells.
Pheochromocytoma
Nerve growth factor activates calcium-insensitive protein kinase C-epsilon in PC-12 rat pheochromocytoma cells.
Pheochromocytoma
Nerve growth factor and fibroblast growth factor regulate neurite outgrowth and gene expression in PC12 cells via both protein kinase C- and cAMP-independent mechanisms.
Pheochromocytoma
Nerve growth factor enhances the level of the protein kinase C substrate B-50 in pheochromocytoma PC12 cells.
Pheochromocytoma
Nerve growth factor stimulates protein kinase C translocation in PC12 cells.
Pheochromocytoma
Nerve growth factor-induced changes in the intracellular localization of the protein kinase C substrate B-50 in pheochromocytoma PC12 cells.
Pheochromocytoma
Nerve growth factor-induced differentiation of PC12 cells employs the PMA-insensitive protein kinase C-zeta isoform.
Pheochromocytoma
Neuronal differentiation of PC12 cells involves changes in protein kinase C-theta distribution and molecular properties.
Pheochromocytoma
Novel Neuroprotective Mechanism of Action of Rasagiline Is Associated with Its Propargyl Moiety: Interaction of Bcl-2 Family Members with PKC Pathway.
Pheochromocytoma
Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cells.
Pheochromocytoma
Overexpression of protein kinase C-delta plays a crucial role in interleukin-6-producing pheochromocytoma presenting with acute inflammatory syndrome: a case report.
Pheochromocytoma
Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells.
Pheochromocytoma
Pituitary adenylate cyclase-activating polypeptide autoregulates cAMP production due to activation of protein kinase C in PC12 pheochromocytoma cells.
Pheochromocytoma
Protein kinase C mediated regulation of calcium channels in PC-12 pheochromocytoma cells.
Pheochromocytoma
Protein kinase C mediates activation of nuclear cAMP response element-binding protein (CREB) in B lymphocytes stimulated through surface Ig.
Pheochromocytoma
Protein kinase Calpha modulates depolarizaton-evoked changes of intracellular Ca2+ concentration in a rat pheochromocytoma cell line.
Pheochromocytoma
Pulsed electromagnetic field and relief of hypoxia-induced neuronal cell death: The signaling pathway.
Pheochromocytoma
Regulation of protein kinase C by nerve growth factor, epidermal growth factor, and phorbol esters in PC12 pheochromocytoma cells.
Pheochromocytoma
Staurosporine-induced neurite outgrowth in PC12 cells is independent of protein kinase C inhibition.
Pheochromocytoma
Stimulation of catecholamine biosynthesis via the protein kinase C pathway by endothelin-1 in PC12 rat pheochromocytoma cells.
Pheochromocytoma
Stimulus coupling to transcription versus secretion in pheochromocytoma cells. Convergent and divergent signal transduction pathways and the crucial roles for route of cytosolic calcium entry and protein kinase C.
Pheochromocytoma
Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C.
Pheochromocytoma
Synergistic effects between protein kinase C and cAMP on activator protein-1 activity and differentiation of PC-12 pheochromocytoma cells.
Pheochromocytoma
The ATP-dependent membrane localization of protein kinase Calpha is regulated by Ca2+ influx and phosphatidylinositol 4,5-bisphosphate in differentiated PC12 cells.
Pheochromocytoma
The protein kinase C activator phorbol-12-myristate-13-acetate enhances cyclic AMP accumulation in pheochromocytoma cells.
Pick Disease of the Brain
Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies.
Pituitary Neoplasms
Activation of protein kinase C inhibits calcium-activated potassium channels in rat pituitary tumour cells.
Pituitary Neoplasms
Activators of protein kinase C and cyclic AMP-dependent protein kinase regulate intracellular calcium levels through distinct mechanisms in mouse anterior pituitary tumor cells.
Pituitary Neoplasms
Analysis of a protein kinase C-alpha mutation in human pituitary tumours.
Pituitary Neoplasms
Bidirectional control of cytosolic free calcium by thyrotropin-releasing hormone in pituitary cells.
Pituitary Neoplasms
Bromocriptine induces parapoptosis as the main type of cell death responsible for experimental pituitary tumor shrinkage.
Pituitary Neoplasms
Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation.
Pituitary Neoplasms
Ectopic expression of a mutant form of PKCalpha originally found in human tumors: aberrant subcellular translocation and effects on growth control.
Pituitary Neoplasms
Effects of protein kinase C down-regulation on secretory events and proopiomelanocortin gene expression in anterior pituitary tumor (AtT-20) cells.
Pituitary Neoplasms
Effects of the putatively oncogenic protein kinase Calpha D294G mutation on enzymatic activity and cell growth and its occurrence in human thyroid neoplasias.
Pituitary Neoplasms
GH3B6 pituitary tumor cell proliferation is mediated by PKCalpha and PKCepsilon via ERK 1/2-dependent pathway.
Pituitary Neoplasms
Gonadotropin-releasing hormone induced Ca2+ influx in nonsecreting pituitary adenoma cells: role of voltage-dependent Ca2+ channels and protein kinase C.
Pituitary Neoplasms
Growth hormone secretion in human acromegalic pituitary adenomas: cyclic adenosine monophosphate and protein kinase C responses.
Pituitary Neoplasms
Hormone-induced redistribution of protein kinase C in human pituitary adenomas.
Pituitary Neoplasms
Immunohistochemical expression of protein kinase C type III in human pituitary adenomas.
Pituitary Neoplasms
Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application.
Pituitary Neoplasms
Involvement of multiple protein kinase C isozymes in the ACTH secretory pathway of AtT-20 cells.
Pituitary Neoplasms
Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.
Pituitary Neoplasms
Phorbol ester activation of protein kinase C inhibits CNP-stimulated cyclic GMP production in the mouse AtT-20 pituitary tumour cell line.
Pituitary Neoplasms
PMA-sensitive protein kinase C is not necessary in TRH-stimulated prolactin release from female rat primary pituitary cells.
Pituitary Neoplasms
Positive feedback of protein kinase C proteolytic activation during apoptosis.
Pituitary Neoplasms
Potent stimulation of large-conductance Ca2+-activated K+ channels by rottlerin, an inhibitor of protein kinase C-delta, in pituitary tumor (GH3) cells and in cortical neuronal (HCN-1A) cells.
Pituitary Neoplasms
Protein kinase C (PKC) activity and PKC messenger RNAs in human pituitary adenomas.
Pituitary Neoplasms
Protein kinase C activity and messenger RNA modulation by estrogen in normal and neoplastic rat pituitary tissue.
Pituitary Neoplasms
siRNA-mediated silencing of bFGF gene inhibits the proliferation, migration, and invasion of human pituitary adenoma cells.
Pituitary Neoplasms
Stimulation of protein synthesis in pituitary cells by phorbol esters and cyclic AMP. Evidence for rapid induction of a component of translational initiation.
Pituitary Neoplasms
Tamoxifen-induced growth arrest and apoptosis in pituitary tumor cells in vitro via a protein kinase C-independent pathway.
Pituitary Neoplasms
The natural protein kinase C alpha mutant is present in human thyroid neoplasms.
Pituitary Neoplasms
The protein kinase C activator 1-oleoyl-2-acetylglycerol inhibits voltage-dependent Ca2+ current in the pituitary cell line AtT-20.
Pituitary Neoplasms
The roles of adenosine 3',5'-cyclic monophosphate-dependent protein kinase A and protein kinase C in stimulus-secretion coupling in AtT-20 cells.
Pituitary Neoplasms
Thyrotropin releasing hormone action in pituitary cells. Protein kinase C-mediated effects on the epidermal growth factor receptor.
Pituitary Neoplasms
Thyrotropin-releasing hormone stimulates c-jun and c-fos messenger ribonucleic acid levels: implications for calcium mobilization and protein kinase-C activation.
Pituitary Neoplasms
[Influence of ACh on the level of protein kinase C, intracellular free Ca(2+) and cyclic AMP/cyclic GMP of cultured human pituitary adenoma cells]
Plasmacytoma
Association of elevated levels of protein kinase C-zeta mRNA and protein with murine B-lymphocytic neoplasia.
Plasmacytoma
Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific.
Plasmacytoma
Mechanism of apoptosis suppression by phorbol ester in IL-6-starved murine plasmacytomas: role of PKC modulation and cell cycle.
Plasmacytoma
Resolution and general properties of different types of ribosomal protein kinases in mouse plasmocytoma.
Pneumonia
Differential regulation of Th2 and Th1 lung inflammatory responses by protein kinase C theta.
Pneumonia
Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.
Pneumonia
Organic dust-induced lung injury and repair: Bi-directional regulation by TNF? and IL-10.
Pneumonia
Protein kinase Czeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications.
Pneumonia
Pulmonary endothelial protein kinase C-delta (PKC?) regulates neutrophil migration in acute lung inflammation.
Pneumoperitoneum
Influence of CO2 pneumoperitoneum on intracellular pH and signal transduction in cancer cells.
Polycystic Kidney Diseases
Autosomal dominant polycystic liver disease in a family without polycystic kidney disease associated with a novel missense protein kinase C substrate 80K-H mutation.
Polycystic Kidney Diseases
Polycystic liver disease: ductal plate malformation and the primary cilium.
Polycystic Kidney Diseases
The polycystic kidney disease 1 gene product mediates protein kinase C alpha-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1.
Polycystic Kidney, Autosomal Dominant
Autosomal dominant polycystic liver disease in a family without polycystic kidney disease associated with a novel missense protein kinase C substrate 80K-H mutation.
Polycystic Kidney, Autosomal Dominant
Polycystic liver disease: ductal plate malformation and the primary cilium.
Polycystic Ovary Syndrome
Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3,4,5,-(PO(4))(3) in Obesity and Polycystic Ovary Syndrome.
Polycythemia Vera
Possible involvement of protein kinase C in the aberrant regulation of erythropoiesis in polycythemia vera.
Polyuria
[Fundamental and applied studies on transport and metabolism of electrolytes and glucose--aim to contact with molecular biology]
Porcine Reproductive and Respiratory Syndrome
Porcine reproductive and respiratory syndrome virus induces HMGB1 secretion via activating PKC-delta to trigger inflammatory response.
Pre-Eclampsia
Mechanism of agonistic angiotensin II type I receptor autoantibody-amplified contractile response to Ang II in the isolated rat thoracic aorta.
Pre-Eclampsia
PKC delta in preeclamptic placentas promotes Bax dissociation from 14-3-3 zeta through 14-3-3 zeta phosphorylation.
Pre-Eclampsia
Protein Kinase C Epsilon Contributes to NADPH Oxidase Activation in a Pre-Eclampsia Lymphoblast Cell Model.
Pre-Eclampsia
The Inhibition of Protein Kinase C ? Contributes to the Pathogenesis of Preeclampsia by Activating Autophagy.
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells.
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Expression of CD9 antigen on normal activated human B cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A requirement for protein kinase C inhibition for calcium-triggered apoptosis in acute lymphoblastic leukemia cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Activated protein kinase C directly phosphorylates the CD34 antigen in acute lymphoblastic leukemia cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effect of an inhibitory factor for protein kinase C on cell growth of leukemic cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effects of azidothymidine on protein kinase C activity and expression in erythroleukemic cell K562 and acute lymphoblastic leukemia cell HSB-2.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression of three major protein kinase C isozymes in various types of human leukemic cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Induction of tumoricidal activity and alterations of growth by interleukin-2 and manipulation of protein kinase C and cytosolic calcium in childhood acute lymphocytic leukemia cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-? and reactive oxygen species.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prognostic value of protein kinase C, proto-oncogene products and resistance-related proteins in newly diagnosed childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prognostic-significance of protein-kinase-C in newly-diagnosed childhood acute lymphoblastic-leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protein kinase C activity and multidrug resistance in MOLT-3 human lymphoblastic leukemia cells resistant to trimetrexate.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Anticancer drug-mediated induction of multidrug resistance-associated genes and protein kinase C isozymes in the T-lymphoblastoid cell line CCRF-CEM and in blasts from patients with acute lymphoblastic leukemias.
Presbycusis
Age-related increase in PKC gamma expression in the cochlear nucleus of hearing impaired C57BL/6J and BALB/c mice.
Primary Myelofibrosis
Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies.
Primary Myelofibrosis
Platelet expression of PKCepsilon oncoprotein in myelofibrosis is associated with disease severity and thrombotic risk.
Prolactinoma
Hybridization studies of cultured human pituitary prl and gh producing adenoma cells: Effects of thyrotropin-releasing hormone, somatostatin, and phorbol ester.
Prolactinoma
Immunohistochemical expression of protein kinase C type III in human pituitary adenomas.
Prostatic Diseases
Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate.
Prostatic Hyperplasia
Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate.
Prostatic Neoplasms
12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha.
Prostatic Neoplasms
12(S)-HETE increases the motility of prostate tumor cells through selective activation of PKC alpha.
Prostatic Neoplasms
12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase.
Prostatic Neoplasms
A novel 3',5'-diprenylated chalcone induces concurrent apoptosis and GSDME-dependent pyroptosis through activating PKC?/JNK signal in prostate cancer.
Prostatic Neoplasms
A Phase II study of high-dose tamoxifen in patients with hormone-refractory prostate cancer.
Prostatic Neoplasms
A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer.
Prostatic Neoplasms
A randomized, double-blind, placebo-controlled, Phase II study with and without enzastaurin in combination with docetaxel-based chemotherapy in patients with castration-resistant metastatic prostate cancer.
Prostatic Neoplasms
Activation of Nuclear Factor-Kappa B (NF?B) in Prostate Cancer is Mediated by PKC Epsilon (PKC{epsilon}).
Prostatic Neoplasms
Activation of Rac1 is closely related to androgen-independent cell proliferation of prostate cancer cells both in vitro and in vivo.
Prostatic Neoplasms
Anticancer activity of the protein kinase C modulator HMI-1a3 in 2D and 3D cell culture models of androgen-responsive and androgen-unresponsive prostate cancer.
Prostatic Neoplasms
Bryostatin 1 induces prolonged activation of extracellular regulated protein kinases in and apoptosis of LNCaP human prostate cancer cells overexpressing protein kinase calpha.
Prostatic Neoplasms
Bryostatin 1 inhibits phorbol ester-induced apoptosis in prostate cancer cells by differentially modulating protein kinase C (PKC) delta translocation and preventing PKCdelta-mediated release of tumor necrosis factor-alpha.
Prostatic Neoplasms
c-fos promoter insensitivity to phorbol ester and possible role of protein kinase C in androgen-independent cancer cells.
Prostatic Neoplasms
Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis.
Prostatic Neoplasms
Ceramide-mediated apoptosis following ionizing radiation in human prostate cancer cells: PKCalpha joins the fray.
Prostatic Neoplasms
Chemosensitization of androgen-independent prostate cancer with neutral endopeptidase.
Prostatic Neoplasms
Coexpression of aPKC?/? and IL-6 in prostate cancer tissue correlates with biochemical recurrence.
Prostatic Neoplasms
Conjugated linoleic acid inhibits proliferation and modulates protein kinase C isoforms in human prostate cancer cells.
Prostatic Neoplasms
Crosstalk of protein kinase C ? with Smad2/3 promotes tumor cell proliferation in prostate cancer cells by enhancing aerobic glycolysis.
Prostatic Neoplasms
Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha.
Prostatic Neoplasms
Differential Sensitization of Different Prostate Cancer Cells to Apoptosis.
Prostatic Neoplasms
Distribution of Thyroliberin (TRH)- and 12-O-tetradecanoylphorbol 13-acetate (TPA)-activated adenylyl cyclase in normal and neoplastic tissue with special reference to the prostate.
Prostatic Neoplasms
Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis.
Prostatic Neoplasms
Down-regulation of protein kinase Ceta potentiates the cytotoxic effects of exogenous tumor necrosis factor-related apoptosis-inducing ligand in PC-3 prostate cancer cells.
Prostatic Neoplasms
Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion.
Prostatic Neoplasms
Effects of the antiandrogen flutamide on the expression of protein kinase C isoenzymes in LNCaP and PC3 human prostate cancer cells.
Prostatic Neoplasms
Fatty acid regulation of protein kinase C isoforms in prostate cancer cells.
Prostatic Neoplasms
Genetic Ablation of PKC Epsilon Inhibits Prostate Cancer Development and Metastasis in Transgenic Mouse Model of Prostate Adenocarcinoma.
Prostatic Neoplasms
Human prostate carcinoma cells express functional alphaIIb(beta)3 integrin.
Prostatic Neoplasms
Human prostate cell lines from normal and tumourigenic epithelia differ in the pattern and control of choline lipid headgroups released into the medium on stimulation of protein kinase C.
Prostatic Neoplasms
Induction of KAI-1 expression in metastatic cancer cells by phorbol esters.
Prostatic Neoplasms
Inhibition of 5-lipoxygenase triggers apoptosis in prostate cancer cells via down-regulation of protein kinase C-epsilon.
Prostatic Neoplasms
Inhibition of matrix metalloproteinase activity in DU145 human prostate cancer cells by flavonoids from lowbush blueberry (Vaccinium angustifolium): possible roles for protein kinase C and mitogen-activated protein-kinase-mediated events.
Prostatic Neoplasms
Inhibition of potentially anti-apoptotic proteins by antisense protein kinase C-alpha (Isis 3521) and antisense bcl-2 (G3139) phosphorothioate oligodeoxynucleotides: relationship to the decreased viability of T24 bladder and PC3 prostate cancer cells.
Prostatic Neoplasms
Inhibition of protein kinase C/Twist1 signaling augments anticancer effects of androgen deprivation and enzalutamide in prostate cancer.
Prostatic Neoplasms
Inhibitory effect of epidermal growth factor on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-alpha.
Prostatic Neoplasms
Inositol hexaphosphate represses telomerase activity and translocates TERT from the nucleus in mouse and human prostate cancer cells via the deactivation of Akt and PKCalpha.
Prostatic Neoplasms
Integrin signaling links protein kinase Cepsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells.
Prostatic Neoplasms
Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta.
Prostatic Neoplasms
JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA).
Prostatic Neoplasms
Liposomes Targeting P21 Activated Kinase-1 (PAK-1) and Selective for Secretory Phospholipase A2 (sPLA2) Decrease Cell Viability and Induce Apoptosis in Metastatic Triple-Negative Breast Cancer Cells.
Prostatic Neoplasms
Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells.
Prostatic Neoplasms
Lysophosphatidic acid induces reactive oxygen species generation by activating protein kinase C in PC-3 human prostate cancer cells.
Prostatic Neoplasms
Manipulating expression of endogenous oncogenic proteins using an antisense oligonucleotide approach in prostate cancer cells.
Prostatic Neoplasms
Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance.
Prostatic Neoplasms
MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells.
Prostatic Neoplasms
Neutral endopeptidase promotes phorbol ester-induced apoptosis in prostate cancer cells by inhibiting neuropeptide-induced protein kinase C delta degradation.
Prostatic Neoplasms
Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex.
Prostatic Neoplasms
Oral enzastaurin in prostate cancer: A two-cohort phase II trial in patients with PSA progression in the non-metastatic castrate state and following docetaxel-based chemotherapy for castrate metastatic disease.
Prostatic Neoplasms
Overexpression of PKCepsilon sensitizes LNCaP human prostate cancer cells to induction of apoptosis by bryostatin 1.
Prostatic Neoplasms
Overexpression of protein kinase C-zeta (PKC-zeta) inhibits invasive and metastatic abilities of Dunning R-3327 MAT-LyLu rat prostate cancer cells.
Prostatic Neoplasms
PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism.
Prostatic Neoplasms
Persistent membrane translocation of protein kinase C alpha during 12-0-tetradecanoylphorbol-13-acetate-induced apoptosis of LNCaP human prostate cancer cells.
Prostatic Neoplasms
Phorbol ester-induced apoptosis in prostate cancer cells via autocrine activation of the extrinsic apoptotic cascade: a key role for protein kinase C delta.
Prostatic Neoplasms
PKC? facilitates lymphatic metastatic spread of prostate cancer cells in a mice xenograft model.
Prostatic Neoplasms
PKC? in prostate cancer cells represses the recruitment and M2 polarization of macrophages in the prostate cancer microenvironment.
Prostatic Neoplasms
PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo.
Prostatic Neoplasms
PRKC-? Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and Is a Novel Target for Therapeutic Intervention.
Prostatic Neoplasms
Prolactin regulation of mitochondrial aspartate aminotransferase and protein kinase C in human prostate cancer cells.
Prostatic Neoplasms
Prostate cancer cell growth inhibition by tamoxifen is associated with inhibition of protein kinase C and induction of p21(waf1/cip1).
Prostatic Neoplasms
Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles.
Prostatic Neoplasms
Protein kinase C and prostate carcinogenesis: targeting the cell cycle and apoptotic mechanisms.
Prostatic Neoplasms
Protein kinase C epsilon mediates the induction of P-glycoprotein in LNCaP prostate carcinoma cells.
Prostatic Neoplasms
Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells.
Prostatic Neoplasms
Protein kinase C is inhibited by bisphosphonates in prostate cancer PC-3 cells.
Prostatic Neoplasms
Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer.
Prostatic Neoplasms
Protein kinase C mu is down-regulated in androgen-independent prostate cancer.
Prostatic Neoplasms
Protein kinase C pathway is involved in regulating the secretion of prostatic acid phosphatase in human prostate cancer cells.
Prostatic Neoplasms
Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway.
Prostatic Neoplasms
Protein kinase C regulates Twist1 expression via NF-?B in prostate cancer.
Prostatic Neoplasms
Protein kinase C-{alpha} mediates epidermal growth factor receptor transactivation in human prostate cancer cells.
Prostatic Neoplasms
Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells.
Prostatic Neoplasms
Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer.
Prostatic Neoplasms
Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells.
Prostatic Neoplasms
Protein Kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer.
Prostatic Neoplasms
Protein Kinase C{gamma} Regulates Myosin IIB Phosphorylation, Cellular Localization, and Filament Assembly.
Prostatic Neoplasms
RB activation and repression of C-MYC transcription precede apoptosis of human prostate epithelial cells.
Prostatic Neoplasms
Regulation of caveolin-1 expression and secretion by a protein kinase cepsilon signaling pathway in human prostate cancer cells.
Prostatic Neoplasms
Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway.
Prostatic Neoplasms
Resveratrol antagonizes EGFR-dependent Erk1/2 activation in human androgen-independent prostate cancer cells with associated isozyme-selective PKC alpha inhibition.
Prostatic Neoplasms
Ribozyme-mediated inhibition of PKCalpha sensitizes androgen-independent human prostate cancer cells to cisplatin-induced apoptosis.
Prostatic Neoplasms
Splice variant PRKC-?(-PrC) is a novel biomarker of human prostate cancer.
Prostatic Neoplasms
Targeting protein kinase C (PKC) and telomerase by phenethyl isothiocyanate (PEITC) sensitizes PC-3 cells towards chemotherapeutic drug-induced apoptosis.
Prostatic Neoplasms
The protein kinase C activator, phorbol ester, elicits disparate functional responses in androgen-sensitive and androgen-independent human prostatic cancer cells.
Prostatic Neoplasms
The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression.
Prostatic Neoplasms
The TGF-? signalling negative regulator PICK1 represses prostate cancer metastasis to bone.
Prostatic Neoplasms
Transcriptional activation of PRMT5 by NF-Y is required for cell growth and negatively regulated by the PKC/c-Fos signaling in prostate cancer cells.
Prostatic Neoplasms
Transforming growth factor-beta1 inhibits membrane association of protein kinase C alpha in a human prostate cancer cell line, PC3.
Prostatic Neoplasms
Virtual screening of PRK1 inhibitors: ensemble docking, rescoring using binding free energy calculation and QSAR model development.
Protein Deficiency
Dietary protein deficiency induced changes in protein kinase C activity and phospholipid metabolism in rat hepatocytes.
Protein Deficiency
Effect of dietary protein manipulation on translocation of protein kinase C activity in various tissues of rats.
Protein Deficiency
Expression of T lymphocyte p56(lck), a zinc-finger signal transduction protein, is elevated by dietary zinc deficiency and diet restriction in mice.
Protein Deficiency
Phospholipid metabolism and protein kinase C mediated protein phosphorylation in dietary protein deficiency in rat lung.
protein kinase c deficiency
Impaired microbial killing by neutrophils from patients with protein kinase C delta deficiency.
protein kinase c deficiency
Insulin action in normal and protein kinase C-deficient rat hepatoma cells. Effects on protein phosphorylation, protein kinase activities, and ornithine decarboxylase activities and messenger ribonucleic acid levels.
protein kinase c deficiency
Loss of protein kinase Cbeta function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance.
protein kinase c deficiency
Natural killer cells from protein kinase C theta-/- mice stimulated with interleukin-12 are deficient in production of interferon-gamma.
protein kinase c deficiency
PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance.
protein kinase c deficiency
PICK1 deficiency causes male infertility in mice by disrupting acrosome formation.
protein kinase c deficiency
PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury.
protein kinase c deficiency
PICK1 deficiency exacerbates sepsis-associated acute lung injury and impairs glutathione synthesis via reduction of xCT.
protein kinase c deficiency
PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance.
protein kinase c deficiency
PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury.
protein kinase c deficiency
PICK1 Regulates the Expression and Trafficking of AMPA Receptors in Remifentanil-Induced Hyperalgesia.
protein kinase c deficiency
PKC-epsilon deficiency alters progenitor cell populations in favor of megakaryopoiesis.
protein kinase c deficiency
PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance.
protein kinase c deficiency
Protein kinase C deficiency blocks recovery from agonist-induced desensitization.
protein kinase c deficiency
Protein kinase C deficiency in juvenile chronic myeloid leukemia: a case report.
protein kinase c deficiency
Protein kinase C deficiency increases fatty acid oxidation and reduces fat storage.
protein kinase c deficiency
The PICK1/TLR4 complex on microglia is involved in the regulation of LPS-induced sepsis-associated encephalopathy.
protein kinase c deficiency
The SLAM-associated protein signaling pathway is required for development of CD4+ T cells selected by homotypic thymocyte interaction.
Protein-Energy Malnutrition
Expression of T lymphocyte p56(lck), a zinc-finger signal transduction protein, is elevated by dietary zinc deficiency and diet restriction in mice.
Proteinuria
Activation of protein kinase c-delta and c-epsilon by oxidative stress in early diabetic rat kidney.
Proteinuria
Capacity of H2O2 release from monocytes in steroid-sensitive nephrotic syndrome.
Proteinuria
Dual Inhibition of Classical Protein Kinase C-? and Protein Kinase C-? Isoforms Protects Against Experimental Murine Diabetic Nephropathy.
Proteinuria
Evaluation of renal gene expression of protein kinase C (PKC) isoforms in diabetic and nondiabetic proliferative glomerular diseases.
Proteinuria
PKC{alpha} Mediates {beta}-Arrestin2-dependent Nephrin Endocytosis in Hyperglycemia.
Pseudorabies
Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1.
Psoriasis
A study on altered expression of serine palmitoyltransferase and ceramidase in psoriatic skin lesion.
Psoriasis
Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways.
Psoriasis
Ceramides and Cell Signaling Molecules in Psoriatic Epidermis: Reduced Levels of Ceramides, PKC-alpha, and JNK.
Psoriasis
Differential expression of protein kinase C isoenzymes in normal and psoriatic adult human skin: reduced expression of protein kinase C-beta II in psoriasis.
Psoriasis
Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases.
Psoriasis
Down-regulation of Langerhans cell protein kinase C-beta isoenzyme expression in inflammatory and hyperplastic dermatoses.
Psoriasis
Increased phospholipase C-catalyzed hydrolysis of phosphatidylinositol-4,5-bisphosphate and 1,2-sn-diacylglycerol content in psoriatic involved compared to uninvolved and normal epidermis.
Psoriasis
Protein kinase C activity in normal and psoriatic cells: cultures of fibroblasts and lymphocytes.
Psoriasis
Protein kinase C in normal human epidermal keratinocytes during proliferation and calcium-induced differentiation.
Psoriasis
SCH 47112, a novel staurosporine derivative, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and epidermal hyperplasia in hairless mouse skin.
Psoriasis
Sotrastaurin, a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis.
Pterygium
Expression of gelatinase (MMP-2 and MMP-9) in pterygia and pterygium fibroblasts is increased with disease progression and activation of protein kinase C.
Pulmonary Disease, Chronic Obstructive
A Myristoylated Alanine-Rich C Kinase Substrate-Related Peptide Suppresses Cytokine mRNA and Protein Expression in LPS-Activated Canine Neutrophils.
Pulmonary Disease, Chronic Obstructive
Changes of protein kinase Calpha and cyclin D1 expressions in pulmonary arteries from smokers with and without chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Normalization of deranged signal transduction in lymphocytes of COPD patients by the novel calcium channel blocker H-DHPM.
Pulmonary Disease, Chronic Obstructive
Pharmacological inhibition of protein kinase C (PKC)? downregulates the expression of cytokines involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).
Pulmonary Disease, Chronic Obstructive
The effect of extracellular matrix remodeling on airflow obstruction in a rat model of chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
[Expression of protein kinase C and nuclear factor kappa B in lung tissue of patients with chronic obstructive pulmonary disease.]
Pulmonary Edema
Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury.
Pulmonary Fibrosis
Interleukin (IL)-13, Prostaglandin E2 (PGE2), and Prostacyclin 2 (PGI2) Activate Hepatic Stellate Cells via Protein kinase C (PKC) Pathway in Hepatic Fibrosis.
Pulmonary Fibrosis
Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis.
Pulmonary Fibrosis
Protein Kinase C ? (PKC?) Attenuates Bleomycin Induced Pulmonary Fibrosis via Inhibiting NF-?B Signaling Pathway.
Purpura, Thrombocytopenic, Idiopathic
Effect of protein kinase C on proliferation and apoptosis of T lymphocytes in idiopathic thrombocytopenic purpura children.
Purpura, Thrombocytopenic, Idiopathic
Effect of protein kinase C on T lymphocyte proliferation and apoptosis in acute idiopathic thrombocytopenic purpura.
Purpura, Thrombocytopenic, Idiopathic
[Analysis of protein kinase C activity of peripheral blood T lymphocytes in children with acute idiopathic thrombocytopenic purpura]
Rabies
The phosphoprotein of rabies virus is phosphorylated by a unique cellular protein kinase and specific isomers of protein kinase C.
Renal Insufficiency, Chronic
Evaluation of renal gene expression of protein kinase C (PKC) isoforms in diabetic and nondiabetic proliferative glomerular diseases.
Renal Insufficiency, Chronic
Investigation of the effects of indoxyl sulfate, a uremic toxin, on the intracellular oxidation level and phagocytic activity using an HL-60-differentiated human macrophage cell model.
Reperfusion Injury
Activation of epsilon protein kinase C correlates with a cardioprotective effect of regular ethanol consumption.
Reperfusion Injury
Attenuation of renal ischemia-reperfusion injury by postconditioning involves adenosine receptor and protein kinase C activation.
Reperfusion Injury
Cardiac preconditioning with calcium: clinically accessible myocardial protection.
Reperfusion Injury
Cardiopulmonary bypass with cardioplegic arrest activates protein kinase C in the human myocardium.
Reperfusion Injury
Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury.
Reperfusion Injury
Chronic prenatal hypoxia induces epigenetic programming of PKC{epsilon} gene repression in rat hearts.
Reperfusion Injury
deltaPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart.
Reperfusion Injury
Differential activation of protein kinase C between ischemic and pharmacological preconditioning in the rabbit heart.
Reperfusion Injury
Differential loss of cytochrome-c oxidase subunits in ischemia-reperfusion injury: exacerbation of COI subunit loss by PKC-epsilon inhibition.
Reperfusion Injury
Direct effect of cocaine on epigenetic regulation of PKCepsilon gene repression in the fetal rat heart.
Reperfusion Injury
Effects of protein kinase C inhibitors in in situ and isolated ischemic rabbit myocardium.
Reperfusion Injury
epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury.
Reperfusion Injury
Foetal nicotine exposure causes PKC{varepsilon} gene repression by promoter methylation in rat hearts.
Reperfusion Injury
Improvement of ischemia-reperfusion-induced myocardial dysfunction by modulating calcium-overload using a novel, specific calmodulin antagonist, CGS 9343B.
Reperfusion Injury
Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo.
Reperfusion Injury
Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators.
Reperfusion Injury
Ischemic postconditioning as a novel avenue to protect against brain injury after stroke.
Reperfusion Injury
Landiolol has cardioprotective effects against reperfusion injury in the rat heart via the PKCepsilon signaling pathway.
Reperfusion Injury
Limb Remote Postconditioning Alleviates Cerebral Reperfusion Injury Through Reactive Oxygen Species-Mediated Inhibition of Delta Protein Kinase C in Rats.
Reperfusion Injury
Loss of Ribosomal RACK1 (Receptor for Activated Protein Kinase C 1) Induced by Phosphorylation at T50 Alleviates Cerebral Ischemia-Reperfusion Injury in Rats.
Reperfusion Injury
Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling.
Reperfusion Injury
Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury.
Reperfusion Injury
Morphine Postconditioning Protects Against Reperfusion Injury: the Role of Protein Kinase C-Epsilon, Extracellular Signal-Regulated Kinase 1/2 and Mitochondrial Permeability Transition Pores.
Reperfusion Injury
Myocardial Hsp70 phosphorylation and PKC-mediated cardioprotection following exercise.
Reperfusion Injury
Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin.
Reperfusion Injury
PKC? and PKC? are Differentially Activated and Modulate Neurotoxic Signaling Pathways During Oxygen Glucose Deprivation in Rat Cortical Slices.
Reperfusion Injury
Platelet activating factor: the good and the bad in the ischemic/reperfused heart.
Reperfusion Injury
Prenatal hypoxia causes a sex-dependent increase in heart susceptibility to ischemia and reperfusion injury in adult male offspring: role of protein kinase C epsilon.
Reperfusion Injury
Pretreatment with PKC activator protects cardiomyocytes against reoxygenation-induced hypercontracture independently of Ca2+ overload.
Reperfusion Injury
Protective effect of urantide against ischemia-reperfusion injury via protein kinase C and phosphtidylinositol 3'-kinase - Akt pathway.
Reperfusion Injury
Protein kinase C and myocardial calcium handling during ischemia and reperfusion: lessons learned using Rhod-2 spectrofluorometry.
Reperfusion Injury
Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation.
Reperfusion Injury
Protein Kinase C Inhibition Ameliorates Posttransplantation Preservation Injury in Rat Renal Transplants.
Reperfusion Injury
Protein kinase C inhibitors abolish the increased resistance of diabetic rat heart to ischemia-reperfusion injury.
Reperfusion Injury
Protein kinase C mediates Ca2(+)-induced cardioadaptation to ischemia-reperfusion injury.
Reperfusion Injury
Protein kinase C-epsilon is involved in the adenosine-activated signal transduction pathway conferring protection against ischemia-reperfusion injury in primary rat neuronal cultures.
Reperfusion Injury
Protein kinase C-zeta inhibition exerts cardioprotective effects in ischemia-reperfusion injury.
Reperfusion Injury
Selective inhibition of protein kinase C ?2 attenuates the adaptor P66(Shc)-mediated intestinal ischemia-reperfusion injury.
Reperfusion Injury
Sevoflurane Preconditioning Reduces Intestinal Ischemia-Reperfusion Injury: Role of Protein Kinase C and Mitochondrial ATP-Sensitive Potassium Channel.
Reperfusion Injury
Sotrastaurin, a protein kinase C inhibitor, ameliorates ischemia and reperfusion injury in rat orthotopic liver transplantation.
Reperfusion Injury
SPC-100270, a protein kinase C inhibitor, reduced hypoxic injury due to reperfusion following orthotopic liver transplantation in the rat.
Reperfusion Injury
Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood-Brain Barrier in a Focal Cerebral Ischemic Insult.
Reperfusion Injury
The protective effects of puerarin in cardiomyocytes from anoxia/reoxygenation injury are mediated by PKC?
Reperfusion Injury
The role of Akt (protein kinase B) and protein kinase C in ischemia-reperfusion injury.
Reperfusion Injury
The role of protein kinase C in cerebral ischemic and reperfusion injury.
Reperfusion Injury
Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2.
Reperfusion Injury
[Effect of electroacupuncture on cerebral PKC isozyme expression levels in cerebral ischemia-reperfusion rats].
Reperfusion Injury
[Role of protein kinase C in protecting rats against pulmonary ischemia reperfusion injury through opening of mitochondrial ATP sensitive potassium channel]
Respiratory Insufficiency
Activation of Protein Kinase C (PKC)? or PKC{varepsilon} as an Approach to Increase Morphine Tolerance in Respiratory Depression and Lethal Overdose.
Respiratory Insufficiency
Effect of Tamoxifen and Brain-Penetrant Protein Kinase C and c-Jun N-Terminal Kinase Inhibitors on Tolerance to Opioid-Induced Respiratory Depression in Mice.
Respiratory Insufficiency
Oxycodone-induced Tolerance to Respiratory Depression: Reversal by Ethanol, Pregabalin, and Protein Kinase C Inhibition.
Respiratory Syncytial Virus Infections
Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase.
Retinal Degeneration
Altered regulation of L-type channels by protein kinase C and protein tyrosine kinases as a pathophysiologic effect in retinal degeneration.
Retinal Degeneration
Photoreceptor deactivation and retinal degeneration mediated by a photoreceptor-specific protein kinase C.
Retinal Degeneration
Protein kinase C-zeta mediates retinal degeneration in response to TNF.
Retinal Degeneration
The activation of the atypical PKC zeta in light-induced retinal degeneration and its involvement in L-DNase II control.
Retinal Detachment
Retinal Pigment Epithelium Atrophy 1 (rpea1): A New Mouse Model With Retinal Detachment Caused by a Disruption of Protein Kinase C, ?.
Retinal Neovascularization
Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization.
Retinal Neovascularization
Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor.
Retinal Neovascularization
Ruboxistaurin, a PKCbeta inhibitor, inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.
Retinoblastoma
Ceramide regulates cellular homeostasis via diverse stress signaling pathways.
Retinoblastoma
Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization.
Retinoblastoma
Mediation of corticotropin releasing factor type 1 receptor phosphorylation and desensitization by protein kinase C: a possible role in stress adaptation.
Retinoblastoma
Okadaic acid suppresses TPA-induced differentiation by stimulating G1/S transition in human myeloblastic leukaemia ML-1 cells.
Retinoblastoma
Pineal and retinal protein kinase C isoenzymes: cooperative activation by calcium and zinc metallothionein.
Retinoblastoma
PKC delta-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells.
Retinoblastoma
Protein kinase C inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein.
Retinoblastoma
Protein kinase C isozyme-mediated cell cycle arrest involves induction of p21(waf1/cip1) and p27(kip1) and hypophosphorylation of the retinoblastoma protein in intestinal epithelial cells.
Retinoblastoma
Regulation of NeuroD expression by activation of the protein kinase-C pathway in Y79 human retinoblastoma cells.
Retinoblastoma
Regulation of the cancer cell membrane lipid composition by NaCHOleate: Effects on cell signaling and therapeutical relevance in glioma.
Retinoblastoma
Retinoblastoma protein-dependent growth signal conflict and caspase activity are required for protein kinase C-signaled apoptosis of prostate epithelial cells.
Retinoblastoma
Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids.
Retinoblastoma
The expression of keratin k10 in the basal layer of the epidermis inhibits cell proliferation and prevents skin tumorigenesis.
Retinoblastoma
The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors.
Retinopathy of Prematurity
Pharmacological Interventions for Vascular Targeting in Retinopathy of Prematurity: An Experimental Study.
Rhabdomyosarcoma
Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma.
Rhabdomyosarcoma
Rapid activation and down-regulation of protein kinase C alpha in 12-O-Tetradecanoylphorbol-13-acetate-induced differentiation of human rhabdomyosarcoma cells.
Rhabdomyosarcoma
Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: the role of protein kinase C (PKC).
Rhabdomyosarcoma, Alveolar
Phosphorylation profiles of protein kinases in alveolar and embryonal rhabdomyosarcoma.
Rhabdomyosarcoma, Alveolar
Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma.
Rhabdomyosarcoma, Alveolar
Roles of partitioning-defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells.
Rhabdomyosarcoma, Embryonal
Phosphorylation profiles of protein kinases in alveolar and embryonal rhabdomyosarcoma.
Rhabdomyosarcoma, Embryonal
PKCalpha-mediated ERK, JNK and p38 activation regulates the myogenic program in human rhabdomyosarcoma cells.
Rheumatic Heart Disease
Coordination of PRKCA/PRKCA-AS1 interplay facilitates DNA methyltransferase 1 recruitment on DNA methylation to affect protein kinase C alpha transcription in mitral valve of rheumatic heart disease.
Rhinitis, Allergic
[The role of protein kinase C and activator protein-1 signal cascade in the regulation of expression of interleukin-5 in T lymphocyte of allergic rhinitis]
Rift Valley Fever
Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon.
Salmonella Infections
Phosphoproteomic analysis of Salmonella-infected cells identifies key kinase regulators and SopB-dependent host phosphorylation events.
Sarcoma
A novel requirement for Janus kinases as mediators of drug resistance induced by fibroblast growth factor-2 in human cancer cells.
Sarcoma
A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial.
Sarcoma
Chromosomal localisation and genetic variation of the SLC11A1 gene in goats (Capra hircus).
Sarcoma
DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours.
Sarcoma
EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers.
Sarcoma
Endosome-mediated retrograde axonal transport of P2X(3) receptor signals in primary sensory neurons.
Sarcoma
Evidence for involvement of the protein kinase C pathway in the activation of p37v-mos protein kinase.
Sarcoma
Expression of muscarinic receptors in human and mouse sclera and their role in the regulation of scleral fibroblasts proliferation.
Sarcoma
In vitro and in vivo studies of murine sarcoma cells after prolonged treatment with promoting phorbol ester TPA.
Sarcoma
Induction of apoptosis by hepatocyte growth factor/scatter factor and its augmentation by phorbol esters in Meth A cells.
Sarcoma
Inhibition of PKCalpha activation in human bone and soft tissue sarcoma cells by the selective PKC inhibitor PKC412.
Sarcoma
Involvement of protein kinase C in taxol-induced polyploidization in a cultured sarcoma cell line.
Sarcoma
Letter: correlation between phosphorylation ratios by matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis and enzyme kinetics.
Sarcoma
Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes.
Sarcoma
Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias.
Sarcoma
Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-?B and matrix metalloproteinase-2/-9 signaling pathways.
Sarcoma
Uneven distribution of protein kinase C-alpha and -beta isozymes in human sarcomas and carcinomas.
Sarcoma
Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.
Sarcoma
Walleye dermal sarcoma virus Orf B functions through receptor for activated C kinase (RACK1) and protein kinase C.
Sarcoma 180
Protein kinase C in adriamycin action and resistance in mouse sarcoma 180 cells.
Sarcoma 180
Reversal of doxorubicin-resistance in sarcoma 180 tumor cells by inhibition of different resistance mechanisms.
Sarcoma, Avian
Chaperone properties of pdia3 participate in rapid membrane actions of 1?,25-dihydroxyvitamin d3.
Sarcoma, Avian
Cytosolic malic dehydrogenase activity is associated with a putative substrate for the transforming gene product of Rous sarcoma virus.
Sarcoma, Avian
Expression of the v-src or v-fps oncogene increases fructose 2,6-bisphosphate in chick-embryo fibroblasts. Novel mechanism for the stimulation of glycolysis by retroviruses.
Sarcoma, Avian
Protein kinase and its regulatory effect on reverse transcriptase activity of Rous sarcoma virus.
Sarcoma, Avian
Regulation of protein kinase C by cyclic adenosine 3':5'-monophosphate and a tumor promoter in skeletal myoblasts.
Sarcoma, Avian
The oncogenic protein p60v-src has competence activity but does not activate phosphatidylinositol turnover or protein kinase C in Balb/c 3T3 cells.
Sarcoma, Avian
Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes.
Sarcoma, Ewing
Caveolin-1 promotes resistance to chemotherapy-induced apoptosis in Ewing's sarcoma cells by modulating PKCalpha phosphorylation.
Sarcoma, Ewing
Protein kinase C-theta regulates KIT expression and proliferation in gastrointestinal stromal tumors.
Scleroderma, Systemic
Effect of protein kinase C delta (PKC-?) inhibition on the transcriptome of normal and systemic sclerosis human dermal fibroblasts in vitro.
Scleroderma, Systemic
Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts.
Seizures
Alterations of protein kinase C isozyme and substrate proteins in mouse brain after electroconvulsive seizures.
Seizures
Amygdala kindling-induced seizures selectively impair spatial memory. 1. Behavioral characteristics and effects on hippocampal neuronal protein kinase C isoforms.
Seizures
Cell type-specific upregulation of myristoylated alanine-rich C kinase substrate and protein kinase C-alpha, -beta I, -beta II, and -delta in microglia following kainic acid-induced seizures.
Seizures
Differential changes in the activities of multiple protein kinase C subspecies in the hippocampal-kindled rat.
Seizures
Differential regulation of primary protein kinase C substrate (MARCKS, MLP, GAP-43, RC3) mRNAs in the hippocampus during kainic acid-induced seizures and synaptic reorganization.
Seizures
Differential subcellular redistribution of protein kinase C isozymes in the rat hippocampus induced by kainic acid.
Seizures
Electroconvulsive seizure increases phosphorylation of PKC substrates, including GAP-43, MARCKS, and neurogranin, in rat brain.
Seizures
Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner.
Seizures
Enduring increase in membrane-associated protein kinase C activity in the hippocampal-kindled rat.
Seizures
Excitatory amino acid-elicited tonic convulsions in mice and N-methyl-D-aspartate receptor activation: role of Ca(2+) influx and involvement of intracellular Ca(2+)-dependent biochemical processes.
Seizures
Ganglioside GT1B and melatonin inhibit brain mitochondrial DNA damage and seizures induced by kainic acid in mice.
Seizures
Impact of protein kinase C activation on status epilepticus and epileptogenesis: oh, what a tangled web.
Seizures
Kindled amygdaloid seizures in rats cause immediate and transient increase in protein kinase C activity followed by transient suppression of the activity.
Seizures
Long-lasting enhancement of the membrane-associated protein kinase C activity in the hippocampal kindled rat.
Seizures
Long-lasting increase in protein kinase C activity in the hippocampus of amygdala-kindled rat.
Seizures
Protein kinase C activity and subcellular distribution in rat brain following repeated electroconvulsive seizures.
Seizures
Reduced ethanol withdrawal severity and altered withdrawal-induced c-fos expression in various brain regions of mice lacking protein kinase C-epsilon.
Seizures
Seizures selectively impair agonist-stimulated phosphoinositide hydrolysis without affecting protein kinase C activity in rat brain.
Seizures
Selective up-regulation of protein kinase C epsilon in granule cells after kainic acid-induced seizures in rat.
Seizures
The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus.
Seizures, Febrile
Protein kinase C-? contributes to a chronic inhibitory effect of IL-1? on voltage-gated sodium channels in mice with febrile seizure.
Sepsis
A novel microfluidic assay reveals a key role for protein kinase C ? in regulating human neutrophil-endothelium interaction.
Sepsis
Activation-induced depletion of protein kinase C alpha provokes desensitization of monocytes/macrophages in sepsis.
Sepsis
Alterations in bidirectional transmembrane calcium flux occur without changes in protein kinase C levels in rat aorta during sepsis.
Sepsis
Alterations in splenic and hepatic protein kinase C in sepsis and chronic endotoxemia.
Sepsis
Alternation of Na(+)-Ca2+ exchange in rat cardiac sarcolemmal membranes during different phases of sepsis.
Sepsis
Circular RNA PRKCI and microRNA-545 relate to sepsis risk, disease severity and 28-day mortality.
Sepsis
Complement activation alters myocellular sodium homeostasis during polymicrobial sepsis.
Sepsis
Inactivation of protein kinase C in rat liver during late hypoglycemic phase of sepsis.
Sepsis
K252a, a potent protein kinase inhibitor, improves endotoxic lethality and glucose dyshomeostasis.
Sepsis
Modification of hepatic protein kinase C with phorbol myristate acetate and staurosporine alters hemodynamics in the perfused rat liver.
Sepsis
Modulation of protein kinase C alters hemodynamics and metabolism in the isolated liver in fed and fasted rats.
Sepsis
PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury.
Sepsis
PKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental Sepsis.
Sepsis
PPARgamma1 attenuates cytosol to membrane translocation of PKCalpha to desensitize monocytes/macrophages.
Sepsis
Protein kinase C activity is increased in rat heart during the early hyperdynamic phase of sepsis.
Sepsis
Protein kinase C-delta inhibition is organ-protective, enhances pathogen clearance, and improves survival in sepsis.
Sepsis
Protein kinase C-zeta (PKC-zeta) regulates Kupffer cell apoptosis during experimental sepsis.
Sepsis
Role of cAMP-response element-binding protein phosphorylation in hepatic apoptosis under protein kinase C alpha suppression during sepsis.
Sepsis
Role of Protein Kinase C-delta in regulating platelet activation and platelet-leukocyte interaction during sepsis.
Sepsis
Suppression of protein kinase Calpha triggers apoptosis through down-regulation of Bcl-xL in a rat hepatic epithelial cell line.
Sepsis
The decrease of PKCalpha is associated with hepatic apoptosis at early and late phases of polymicrobial sepsis.
Sepsis
The essential role of PKCalpha in the protective effect of heat-shock pretreatment on TNFalpha-induced apoptosis in hepatic epithelial cell line.
Sepsis
The PICK1/TLR4 complex on microglia is involved in the regulation of LPS-induced sepsis-associated encephalopathy.
Sepsis-Associated Encephalopathy
The PICK1/TLR4 complex on microglia is involved in the regulation of LPS-induced sepsis-associated encephalopathy.
Severe Combined Immunodeficiency
The addition of bryostatin 1 to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy improves response in a CHOP-resistant human diffuse large cell lymphoma xenograft model.
Shock, Septic
Effects of lipopolysaccharide-induced septic shock on rat isolated kidney, possible role of nitric oxide and protein kinase C pathways.
Shock, Septic
Toxic shock syndrome toxin-1 induces inositol phospholipid turnover, protein kinase C translocation, and calcium mobilization in human T cells.
Shock, Septic
Unexpected hyperactivity of myocardial adenylate cyclase system in endotoxic male rats.
Sialic Acid Storage Disease
Regulation and pathophysiological implications of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) as the key enzyme of sialic acid biosynthesis.
Situs Inversus
Receptor subtype and intracellular signal transduction pathway associated with situs inversus induced by alpha 1 adrenergic stimulation in rat embryos.
Skin Diseases
Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases.
Skin Diseases
Epidermal keratinocytes: regulation of multiple cell phenotypes by multiple protein kinase C isoforms.
Skin Diseases
Naturally occurring protein kinase C inhibitors; II. Isolation of oligomeric stilbenes from Caragana sinica.
Skin Diseases
SCH 47112, a novel staurosporine derivative, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and epidermal hyperplasia in hairless mouse skin.
Skin Diseases
Sex differences in rat hepatic cytolethality of the protein kinase C inhibitor safingol: role of biotransformation.
Skin Neoplasms
Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion.
Skin Neoplasms
Epidermal keratinocytes: regulation of multiple cell phenotypes by multiple protein kinase C isoforms.
Skin Neoplasms
Protein kinase C in normal human epidermal keratinocytes during proliferation and calcium-induced differentiation.
Sleep Deprivation
Protein kinase C inhibition rescues manic-like behaviors and hippocampal cell proliferation deficits in the sleep deprivation model of mania.
Sleep Deprivation
Sleep deprivation differentially alters the mRNA and protein levels of neurogranin in rat brain.
Sleep Deprivation
Successful combined therapy with tamoxifen and lithium in a paradoxical sleep deprivation-induced mania model.
Small Cell Lung Carcinoma
c-myc gene-induced alterations in protein kinase C expression: a possible mechanism facilitating myc-ras gene complementation.
Small Cell Lung Carcinoma
Characterization of the protein kinase C signal transduction pathway in cisplatin-sensitive and -resistant human small cell lung carcinoma cells.
Small Cell Lung Carcinoma
Constitutive presence of a catalytic fragment of protein kinase C epsilon in a small cell lung carcinoma cell line.
Small Cell Lung Carcinoma
Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation.
Small Cell Lung Carcinoma
Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer.
Small Cell Lung Carcinoma
Effects of the new selective protein kinase C inhibitor 4'-N-benzoyl staurosporine on cell cycle distribution and growth inhibition in human small cell lung cancer cells.
Small Cell Lung Carcinoma
FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2.
Small Cell Lung Carcinoma
Inhibition of fibroblast growth factor 2-induced apoptosis involves survivin expression, protein kinase C alpha activation and subcellular translocation of Smac in human small cell lung cancer cells.
Small Cell Lung Carcinoma
Properties of classic protein kinase C in human small cell lung carcinoma NCI-H345 cells.
Small Cell Lung Carcinoma
Protein kinase C is not involved in the homologous desensitization of bombesin responses in small cell lung cancer cells.
Small Cell Lung Carcinoma
Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway.
Small Cell Lung Carcinoma
Protein kinase Czeta abrogates the proapoptotic function of Bax through phosphorylation.
Small Cell Lung Carcinoma
Protein kinase D in small cell lung cancer cells: rapid activation through protein kinase C.
Small Cell Lung Carcinoma
Regulation of integrin-mediated adhesion by muscarinic acetylcholine receptors and protein kinase C in small cell lung carcinoma.
Small Cell Lung Carcinoma
Suppression of growth of H-69 small cell lung carcinoma by antagonists of growth hormone releasing hormone and bombesin is associated with an inhibition of protein kinase C signaling.
Small Cell Lung Carcinoma
Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase.
small monomeric gtpase deficiency
The Small GTPase Cdc42 Negatively Regulates the Formation of Neutrophil Extracellular Traps by Engaging Mitochondria.
Spasm
Cellular and molecular mechanisms of coronary artery spasm: lessons from animal models.
Spasm
Coronary artery spasm does not depend on the intracellular calcium store but is substantially mediated by the protein kinase C-mediated pathway in a swine model with interleukin-1 beta in vivo.
Spasm
Diltiazem Inhibits Coronary Spasm via Inhibition of Cav1.2Phosphorylation and Protein Kinase C Activation in a Mouse Model of Coronary Spastic Angina.
Spasm
Upregulations of CRH and CRHR1 in the Epileptogenic Tissues of Patients with Intractable Infantile Spasms.
Spasm
Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of protein kinase C constrictor pathway.
Sphingolipidoses
Inhibition of protein kinase C activity in mucolipidosis type-4: a model for a new pathogenetic mechanism in inborn errors of metabolism.
Sphingolipidoses
Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses.
Spinal Cord Injuries
Comparison of Mesenchymal Stromal Cells Isolated from Murine Adipose Tissue and Bone Marrow in the Treatment of Spinal Cord Injury.
Spinal Cord Injuries
Dexmedetomidine Reduces the Lidocaine-Induced Neurotoxicity by Inhibiting Inflammasome Activation and Reducing Pyroptosis in Rats.
Spinal Cord Injuries
Neuropathic pain and temporal expression of preprodynorphin, protein kinase C and N-methyl-D-aspartate receptor subunits after spinal cord injury.
Spinocerebellar Ataxias
A novel H101Q mutation causes PKCgamma loss in spinocerebellar ataxia type 14.
Spinocerebellar Ataxias
A novel mutation in the C2 domain of protein kinase C gamma associated with spinocerebellar ataxia type 14.
Spinocerebellar Ataxias
Aggregate formation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14 impairs ubiquitin-proteasome system and induces endoplasmic reticulum stress.
Spinocerebellar Ataxias
Altered trafficking of membrane proteins in purkinje cells of SCA1 transgenic mice.
Spinocerebellar Ataxias
Another mutation in cysteine 131 in protein kinase C gamma as a cause of spinocerebellar ataxia type 14.
Spinocerebellar Ataxias
Calcium signaling, PKC gamma, IP3R1 and CAR8 link spinocerebellar ataxias and Purkinje cell dendritic development.
Spinocerebellar Ataxias
Carbonic Anhydrase 8 Expression in Purkinje Cells Is Controlled by PKC? Activity and Regulates Purkinje Cell Dendritic Growth.
Spinocerebellar Ataxias
Clinical and Neurophysiological Profile of Four German Families with Spinocerebellar Ataxia Type 14.
Spinocerebellar Ataxias
Delayed spinocerebellar ataxia in transgenic mice expressing mutant ubiquitin.
Spinocerebellar Ataxias
Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein kinase C gamma that causes spinocerebellar ataxia type 14.
Spinocerebellar Ataxias
Expansion of the phenotypic spectrum of SCA14 caused by the Gly128Asp mutation in PRKCG.
Spinocerebellar Ataxias
Identification and characterization of PKC?, a kinase associated with SCA14, as an amyloidogenic protein.
Spinocerebellar Ataxias
Increased biological activity of protein Kinase C gamma is not required in Spinocerebellar ataxia 14.
Spinocerebellar Ataxias
Increased protein kinase C gamma activity induces Purkinje cell pathology in a mouse model of spinocerebellar ataxia 14.
Spinocerebellar Ataxias
Loss of protein kinase Cgamma in knockout mice and increased retinal sensitivity to hyperbaric oxygen.
Spinocerebellar Ataxias
Molecular pathophysiology of neurodegenerative disease caused by ?PKC mutations.
Spinocerebellar Ataxias
Mutant protein kinase C gamma that causes spinocerebellar ataxia type 14 (SCA14) is selectively degraded by autophagy.
Spinocerebellar Ataxias
Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14.
Spinocerebellar Ataxias
PKC gamma mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling.
Spinocerebellar Ataxias
Protection from ataxia-linked apoptosis by gap junction inhibitors.
Spinocerebellar Ataxias
Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila.
Spinocerebellar Ataxias
Protein kinase C gamma mutations in spinocerebellar ataxia 14 increase kinase activity and alter membrane targeting.
Spinocerebellar Ataxias
Protein kinase C gamma mutations in the C1B domain cause caspase-3-linked apoptosis in lens epithelial cells through gap junctions.
Spinocerebellar Ataxias
Protein kinase C gamma, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin.
Spinocerebellar Ataxias
Reduced Purkinje cell size is compatible with near normal morphology and function of the cerebellar cortex in a mouse model of spinocerebellar ataxia.
Spinocerebellar Ataxias
SCA14 mutation V138E leads to partly unfolded PKC? associated with an exposed C-terminus, altered kinetics, phosphorylation and enhanced insolubilization.
Spinocerebellar Ataxias
Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C gamma.
Squamous Cell Carcinoma of Head and Neck
A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle.
Squamous Cell Carcinoma of Head and Neck
Activation by Tyrosine Phosphorylation as a Prerequisite for Protein Kinase C{zeta} to Mediate Epidermal Growth Factor Receptor Signaling to ERK.
Squamous Cell Carcinoma of Head and Neck
Akt, protein kinase C, and mitogen-activated protein kinase phosphorylation status in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Antitumor activity of enzastaurin as radiation sensitizer in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines.
Squamous Cell Carcinoma of Head and Neck
Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1).
Squamous Cell Carcinoma of Head and Neck
Atypical Protein Kinase C ?/? Expression Is Associated with Malignancy of Oral Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
Ectopic Expression of Protein Kinase C-? Sensitizes Head and Neck Squamous Cell Carcinoma to Diterpene Esters.
Squamous Cell Carcinoma of Head and Neck
Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G.
Squamous Cell Carcinoma of Head and Neck
Induction of endonuclease G-mediated apopotosis in human oral squamous cell carcinoma cells by protein kinase C inhibitor safingol.
Squamous Cell Carcinoma of Head and Neck
Local inflammation may influence oral tumor cell differentiation.
Squamous Cell Carcinoma of Head and Neck
Matrix metalloproteinase 2 and matrix metalloproteinase 9 expression in human oral squamous cell carcinoma and the effect of protein kinase C inhibitors: preliminary observations.
Squamous Cell Carcinoma of Head and Neck
N-(4-hydroxyphenyl)retinamide-induced apoptosis triggered by reactive oxygen species is mediated by activation of MAPKs in head and neck squamous carcinoma cells.
Squamous Cell Carcinoma of Head and Neck
Preclinical development of a bifunctional cancer cell homing, PKCepsilon inhibitory peptide for the treatment of head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma.
Staphylococcal Infections
Improvement of deficient natural killer activity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro.
Starvation
A Protein Kinase C{epsilon}-Anti-apoptotic Kinase Signaling Complex Protects Human Vascular Endothelial Cells against Apoptosis through Induction of Bcl-2.
Starvation
Effect of serum starvation on expression and phosphorylation of PKC-alpha and p53 in V79 cells: implications for cell death.
Starvation
Induction of protein kinase Czeta-related protein kinase by growth suppression in carcinogen-initiated epidermal cell-line WYF31 cells.
Starvation
Inhibition of fibroblast growth factor 2-induced apoptosis involves survivin expression, protein kinase C alpha activation and subcellular translocation of Smac in human small cell lung cancer cells.
Starvation
Inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase enhances chemotherapeutic effects on H460 human non-small cell lung cancer cells through activation of apoptosis.
Starvation
Integrin alpha 5 beta 1 suppresses apoptosis triggered by serum starvation but not phorbol ester in MCF-7 breast cancer cells that overexpress protein kinase C-alpha.
Starvation
Possible involvement of protein kinase C with induction of haptoglobin in cows by treatment with dexamethasone and by starvation.
Starvation
Protein kinase C isoenzymes in human neuroblasts. Involvement of PKC epsilon in cell differentiation.
Starvation
Selective degradation of the PKC-epsilon isoform during cell death in AKR-2B fibroblasts.
Starvation
siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat.
Starvation
The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity.
Starvation
Translational Control of Protein Kinase C{eta} by Two Upstream Open Reading Frames (uORFs).
Status Epilepticus
Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons.
Status Epilepticus
Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus.
Status Epilepticus
Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus.
Status Epilepticus
Impact of protein kinase C activation on epileptiform activity in the hippocampal slice.
Status Epilepticus
Impact of protein kinase C activation on status epilepticus and epileptogenesis: oh, what a tangled web.
Status Epilepticus
mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice.
Status Epilepticus
Pilocarpine-induced status epilepticus alters hippocampal PKC expression in mice.
Status Epilepticus
Protein kinase C activity blocks neuropeptide Y-mediated inhibition of glutamate release and contributes to excitability of the hippocampus in status epilepticus.
Status Epilepticus
Seizures selectively impair agonist-stimulated phosphoinositide hydrolysis without affecting protein kinase C activity in rat brain.
Status Epilepticus
The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus.
Stomach Neoplasms
12-O-tetradecanoylphorbol-1, 3-acetate induces the negative regulation of protein kinase B by protein kinase Calpha during gastric cancer cell apoptosis.
Stomach Neoplasms
Aberrant expression of human mucin gene MUC5B in gastric carcinoma and cancer cells. Identification and regulation of a distal promoter.
Stomach Neoplasms
Activation of matrix metalloproteinase-9 (MMP-9) by neurotensin promotes cell invasion and migration through ERK pathway in gastric cancer.
Stomach Neoplasms
Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in human hepatocellular and gastric cancer xenografts.
Stomach Neoplasms
Antisense expression of PKCalpha improved sensitivity of SGC7901/VCR cells to doxorubicin.
Stomach Neoplasms
Antisense targeting protein kinase C alpha and beta1 inhibits gastric carcinogenesis.
Stomach Neoplasms
Aspirin-induced apoptosis in human gastric cancer epithelial cells: relationship with protein kinase C signaling.
Stomach Neoplasms
Clinical Significance of PRKCI Gene Expression in Cancerous Tissue in Patients With Gastric Cancer.
Stomach Neoplasms
Down-regulation of protein kinase C activity by sorbitol rapidly induces apoptosis in human gastric cancer cell lines.
Stomach Neoplasms
Downregulation of tumor suppressor RACK1 by Helicobacter pylori infection promotes gastric carcinogenesis through the integrin ?-1/NF-?B signaling pathway.
Stomach Neoplasms
EGF rapidly translocates tight junction proteins from the cytoplasm to the cell-cell contact via protein kinase C activation in TMK-1 gastric cancer cells.
Stomach Neoplasms
Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells.
Stomach Neoplasms
Expression and function of classical protein kinase C isoenzymes in gastric cancer cell line and its drug-resistant sublines.
Stomach Neoplasms
High Expression of Atypical Protein Kinase C lambda/iota in Gastric Cancer as a Prognostic Factor for Recurrence.
Stomach Neoplasms
Involvement of TNF-alpha changes in human cancer development, prevention and palliative care.
Stomach Neoplasms
Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc.
Stomach Neoplasms
Pharmacological inhibition of protein kinase C activity could induce apoptosis in gastric cancer cells by differential regulation of apoptosis-related genes.
Stomach Neoplasms
PKCalpha translocation from mitochondria to nucleus is closely related to induction of apoptosis in gastric cancer cells.
Stomach Neoplasms
Protein interacting with C-kinase 1 is involved in epithelial-mesenchymal transformation and suppresses progress of gastric cancer.
Stomach Neoplasms
Protein kinase C activation by PMA rapidly induces apoptosis through caspase-3/CPP32 and serine protease(s) in a gastric cancer cell line.
Stomach Neoplasms
Protein kinase C alpha is the isoform responsible for inhibition of histamine H2 receptor mediated stimulation of adenylate cyclase in the human gastric cancer cell line HGT-1.
Stomach Neoplasms
Protein kinase C and adenylate cyclase as targets for growth inhibition of human gastric cancer cells.
Stomach Neoplasms
Protein kinase C inhibits cyclic adenosine monophosphate generation by histamine and truncated glucagon like peptide 1 in the human gastric cancer cell line HGT-1.
Stomach Neoplasms
Protein kinase C inhibits histamine H2 receptor-mediated stimulation of cyclic AMP content in the human gastric cancer cell line HGT-1.
Stomach Neoplasms
Protein kinase C isozymes regulate matrix metalloproteinase-1 expression and cell invasion in Helicobacter pylori infection.
Stomach Neoplasms
Protein kinase C: a novel target for inhibiting gastric cancer cell invasion.
Stomach Neoplasms
Protein kinase Calpha promotes apoptotic cell death in gastric cancer cells depending upon loss of anchorage.
Stomach Neoplasms
Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells.
Stomach Neoplasms
Roles of PLC-gamma2 and PKCalpha in TPA-induced apoptosis of gastric cancer cells.
Stomach Neoplasms
SSeCKS/Gravin/AKAP12 attenuates expression of proliferative and angiogenic genes during suppression of v-Src-induced oncogenesis.
Stomach Neoplasms
Stimulation of the gastrin-cholecystokinin(B) receptor promotes branching morphogenesis in gastric AGS cells.
Stomach Neoplasms
The alpha isoform of protein kinase C inhibits histamine-stimulated adenylate cyclase activity in a particulate fraction of the human gastric cancer cell line HGT-1.
Stomach Neoplasms
The effect of phorbol esters on cell growth and epidermal growth factor receptor modulation in a human gastric carcinoma cell line TMK-1.
Stomach Neoplasms
[Alteration of subcellular distribution of protein kinase C isoforms in swelling-activated multi-drug-resistant gastric cancer cells and its significance]
Stomach Neoplasms
[Co-regulative effect of PKA-RII and PKC-alpha kinase subspecies on expression of c-myc and c-H-ras in human gastric cancer cells (MGC 80-3)]
Stomach Neoplasms
[Effect of PKC inhibitor on P-gp expression and drug-resistance in MGC803 cells]
Stomach Neoplasms
[Expression and function of protein kinase C-alpha and beta I isoenzymes in drug-resistant gastric cancer cells]
Stomach Ulcer
Activation of Raf-1 during experimental gastric ulcer healing is Ras-mediated and protein kinase C-independent.
Stroke
Activating deltaPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats.
Stroke
Bryostatin Effects on Cognitive Function and PKC? in Alzheimer's Disease Phase IIa and Expanded Access Trials.
Stroke
Cerebrovascular alterations in pressure and protein kinase C-mediated constriction in Dahl salt-sensitive rats.
Stroke
Cerebrovascular recovery after stroke with individual and combined losartan and captopril treatment of SHRsp.
Stroke
Epsilon PKC may contribute to the protective effect of hypothermia in a rat focal cerebral ischemia model.
Stroke
Impact of the 1425G/A Polymorphism of PRKCH on the Recurrence of Ischemic Stroke: Fukuoka Stroke Registry.
Stroke
Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases.
Stroke
Pick1-mediated glutamate receptor subunit 2 (GLUR2) trafficking contributes to cell death in oxygen/glucose deprived hippocampal neurons.
Stroke
Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function.
Stroke
Protein Kinase C Family Members as a Target for Regulation of Blood-Brain Barrier Na,K,2Cl-Cotransporter During In Vitro Stroke Conditions and Nicotine Exposure.
Stroke
Protein kinase Cdelta-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent.
Stroke
Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia.
Stroke
The role of protein kinase C in ischemic tolerance induced by hyperoxia in rats with stroke.
Stroke, Lacunar
A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction.
Stroke, Lacunar
Association between PRKCH gene polymorphisms and subcortical silent brain infarction.
Stuttering
AKAP150 is required for stuttering persistent Ca2+ sparklets and angiotensin II-induced hypertension.
Subacute Sclerosing Panencephalitis
Comparison of the effects of phorbol dibutyrate and low-frequency stimulation of synaptic inputs on the excitability of myenteric AH neurons.
Subacute Sclerosing Panencephalitis
Evidence for protein kinase involvement in long-term postsynaptic excitation of intrinsic primary afferent neurons in the intestine.
Subarachnoid Hemorrhage
Alterations in protein kinase C activity and membrane lipid metabolism in cerebral vasospasm after subarachnoid hemorrhage.
Subarachnoid Hemorrhage
Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain.
Subarachnoid Hemorrhage
Chronological changes of arterial diameter, cGMP, and protein kinase C in the development of vasospasm.
Subarachnoid Hemorrhage
Chronological changes of the contractile mechanism in prolonged vasospasm after subarachnoid hemorrhage: from protein kinase C to protein tyrosine kinase.
Subarachnoid Hemorrhage
Direct evidence for a key role of protein kinase C in the development of vasospasm after subarachnoid hemorrhage.
Subarachnoid Hemorrhage
Dysfunction of nitric oxide induces protein kinase C activation resulting in vasospasm after subarachnoid hemorrhage.
Subarachnoid Hemorrhage
Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm.
Subarachnoid Hemorrhage
Generation of the catalytic fragment of protein kinase C alpha in spastic canine basilar artery.
Subarachnoid Hemorrhage
High-dose methylprednisolone prevents vasospasm after subarachnoid hemorrhage through inhibition of protein kinase C activation.
Subarachnoid Hemorrhage
In vitro evidence of the role of hemoglobin during vasospasm on the modifications of the expression of PKCalpha and zeta.
Subarachnoid Hemorrhage
Inhibition of protein kinase C signal reduces ET receptor expression and basilar vasospasm after subarachnoid hemorrhage in rats.
Subarachnoid Hemorrhage
Interactive role of protein kinase C-delta with rho-kinase in the development of cerebral vasospasm in a canine two-hemorrhage model.
Subarachnoid Hemorrhage
Interrelation between protein kinase C and nitric oxide in the development of vasospasm after subarachnoid hemorrhage.
Subarachnoid Hemorrhage
Possible role of protein kinase C-dependent smooth muscle contraction in the pathogenesis of chronic cerebral vasospasm.
Subarachnoid Hemorrhage
Protein kinase C has two different major roles in lattice compaction enhanced by cerebrospinal fluid from patients with subarachnoid hemorrhage.
Subarachnoid Hemorrhage
Protein kinase cdelta and alpha are involved in the development of vasospasm after subarachnoid hemorrhage.
Subarachnoid Hemorrhage
Relation between protein kinase C and calmodulin systems in cerebrovascular contraction: investigation of the pathogenesis of vasospasm after subarachnoid hemorrhage.
Subarachnoid Hemorrhage
Role of protein kinase C in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage.
Subarachnoid Hemorrhage
Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage.
Subarachnoid Hemorrhage
The immunohistochemical distribution of protein kinase C isozymes is altered in the canine brain and basilar artery after subarachnoid hemorrhage.
Subarachnoid Hemorrhage
Various pathogenetic factors revolving around the central role of protein kinase C activation in the occurrence of cerebral vasospasm
Subarachnoid Hemorrhage
Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of protein kinase C constrictor pathway.
Subarachnoid Hemorrhage
[Role of protein kinase C isozymes in cellular functions and pathological conditions]
Sunburn
Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas.
Sunburn
Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer.
Sunburn
Protein Kinase Cvarepsilon Inhibits UVR-Induced Expression of FADD, an Adaptor Protein, Linked to both Fas- and TNFR1-Mediated Apoptosis.
Supranuclear Palsy, Progressive
Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies.
Synucleinopathies
Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies.
Systemic Vasculitis
The activation of the neutrophil respiratory burst by anti-neutrophil cytoplasm autoantibody (ANCA) from patients with systemic vasculitis requires tyrosine kinases and protein kinase C activation.
Tachycardia
Tachycardia preconditions infarct size in dogs: role of adenosine and protein kinase C.
Takayasu Arteritis
Role of calcium and protein kinase C in the activation of T cells in Takayasu's arteritis.
Tauopathies
Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies.
Temporomandibular Joint Disorders
Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms.
Teratocarcinoma
Characterization of conventional protein kinase C (PKC) isotype expression during F9 teratocarcinoma differentiation. Overexpression of PKC alpha alters the expression of some differentiation-dependent genes.
Teratocarcinoma
Cooperation between retinoic acid and phorbol esters enhances human teratocarcinoma differentiation.
Teratocarcinoma
Differentiation of F9 teratocarcinoma stem cells to primitive endoderm is regulated by the Gialpha2/Gsalpha axis via phospholipase C and not adenylylcyclase.
Teratocarcinoma
Gene activation mediated by protein kinase C in human macrophage and teratocarcinoma cells expressing aminoglycoside phosphotransferase activity.
Teratocarcinoma
Retinoic acid stimulates the protein kinase C pathway before activation of its beta-nuclear receptor during human teratocarcinoma differentiation.
Teratoma
The subcellular distribution of protein kinase Calpha, -epsilon, and -zeta isoforms during cardiac cell differentiation.
Teratozoospermia
A Homozygous Deletion of the DPY19l2 Gene is a Cause of Globozoospermia in Men from the Republic of Macedonia.
Teratozoospermia
Assessment of DPY19L2 Deletion in Familial and Non-Familial Individuals with Globozoospermia and DPY19L2 Genotyping.
Teratozoospermia
Embryos derived from couples with consanguineous marriages with globozoospermia should be screened for gender or DPY19L2 deletion.
Teratozoospermia
Genetic analyses of a large cohort of infertile patients with globozoospermia, DPY19L2 still the main actor, GGN confirmed as a guest player.
Teratozoospermia
ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
Teratozoospermia
Identification of a novel deletion mutation in DPY19L2 from an infertile patient with globozoospermia: a case report.
Teratozoospermia
Molecular Analysis of DPY19L2, PICK1 and SPATA16 in Italian Unrelated Globozoospermic Men.
Teratozoospermia
Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases.
Teratozoospermia
PICK1 deficiency causes male infertility in mice by disrupting acrosome formation.
Teratozoospermia
Rescuing Infertility of Pick1 Knockout Mice by Generating Testis-specific Transgenic Mice via Testicular Infection.
Tetanus
Activation of signal transduction pathways involving trkA, PLCgamma-1, PKC isoforms and ERK-1/2 by tetanus toxin.
Tetanus
Cellular responses to acute injury: the role of the plasma membrane in cell response to two clostridial toxins.
Tetanus
Diminished activity of protein kinase C in tetanus toxin-treated macrophages and in the spinal cord of mice manifesting generalized tetanus intoxication.
Tetanus
Effects of tetanus toxin on catecholamine release from intact and digitonin-permeabilized chromaffin cells.
Tetanus
GT1b ganglioside prevents tetanus toxin-induced protein kinase C activation and down-regulation in the neonatal brain in vivo.
Tetanus
HC fragment (C-terminal portion of the heavy chain) of tetanus toxin activates protein kinase C isoforms and phosphoproteins involved in signal transduction.
Tetanus
In vivo translocation and down-regulation of protein kinase C following intraventricular administration of tetanus toxin.
Tetanus
Inhibition of functional properties of tetanus antigen-specific T-cell clones by envelope glycoprotein GP120 of human immunodeficiency virus.
Tetanus
Metabotropic receptor stimulation coupled to weak tetanus leads to long-term potentiation and a rapid elevation of cytosolic protein kinase C activity.
Tetanus
Postsynaptic protein kinase C essential to induction and maintenance of long-term potentiation in the hippocampal CA1 region.
Tetanus
Protein kinase C and clostridial neurotoxins affect discrete and related steps in the secretory pathway.
Tetanus
Protein kinase C regulates local synthesis and secretion of a neuropeptide required for activity-dependent long-term synaptic plasticity.
Tetanus
Tetanus toxin attenuates the ability of phorbol myristate acetate to mobilize cytosolic protein kinase C in NG-108 cells.
Tetanus
Tetanus toxin enhances protein kinase C activity translocation and increases polyphosphoinositide hydrolysis in rat cerebral cortex preparations.
Tetanus
Tetanus toxin inhibits neurotensin-induced mobilization of cytosolic protein kinase C activity in NG-108 cells.
Tetanus
Tetanus toxin-induced protein kinase C activation and elevated serotonin levels in the perinatal rat brain.
Tetanus
The study of clostridial and related toxins. The search for unique mechanisms and common denominators.
Thecoma
The mechanism for protein kinase C inhibition of androgen production and 17alpha-hydroxylase expression in a theca cell tumor model.
Thrombasthenia
Platelet HDL(3) binding sites are not related to integrin alpha(IIb)beta(3) (GPIIb-IIIa).
Thrombocytopenia
Association of CBFA2 mutation with decreased platelet PKC-theta and impaired receptor-mediated activation of GPIIb-IIIa and pleckstrin phosphorylation: proteins regulated by CBFA2 play a role in GPIIb-IIIa activation.
Thrombocytopenia
Protein kinase C ? deficiency enhances megakaryopoiesis and recovery from thrombocytopenia.
Thrombocytopenia
Successful use of ofatumumab in two cases of early-onset juvenile SLE with thrombocytopenia caused by a mutation in protein kinase C ?.
Thrombocytopenia
[Analysis of protein kinase C activity of peripheral blood T lymphocytes in children with acute idiopathic thrombocytopenic purpura]
Thrombosis
Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation.
Thrombosis
Dual role of platelet protein kinase C in thrombus formation: stimulation of pro-aggregatory and suppression of procoagulant activity in platelets.
Thrombosis
Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen.
Thrombosis
Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation.
Thrombosis
Platelet expression of PKCepsilon oncoprotein in myelofibrosis is associated with disease severity and thrombotic risk.
Thrombosis
Protein kinase C alpha and beta are positive regulators of thrombus formation in vivo in a zebrafish (Danio rerio) model of thrombosis.
Thrombosis
Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2.
Thrombosis
Protein kinase C? and protein kinase C? double-deficient mice have a bleeding diathesis.
Thrombosis
Protein kinase C?/? is dispensable for platelet function in thrombosis and hemostasis in mice.
Thrombosis
The novel NOX inhibitor 2-acetylphenothiazine impairs collagen-dependent thrombus formation in a GPVI-dependent manner.
Thymoma
Calorie restriction initiated at a young age activates the Akt/PKCzeta/lambda-Glut4 pathway in rat white adipose tissue in an insulin-independent manner.
Thymoma
Comparison of phorbol-12-myristate-13-acetate and dioctanoyl-sn-glycerol in the activation of EL4/6.1 thymoma cells.
Thymoma
Concanavalin A- or phorbol ester-induced translocation of protein kinase C in thymoma cells from a patient with myasthenia gravis.
Thymoma
Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin-1 and phorbol ester activation pathways in the EL4-6.1 thymoma cell line.
Thymoma
Effects of protein kinase C activators on phorbol ester-sensitive and -resistant EL4 thymoma cells.
Thymoma
Inhibition of protein kinase C by a peptide conjugate homologous to a domain of the retroviral protein p15E.
Thymoma
Interleukin-1 beta induced synthesis of protein kinase C-delta and protein kinase C-epsilon in EL4 thymoma cells: possible involvement of phosphatidylinositol 3-kinase.
Thymoma
Investigation into the role of protein kinase C in IL1 and PMA signalling in EL4.NOB-1 thymoma cells.
Thymoma
Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation.
Thymoma
Lack of direct effect of 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD) on protein kinase C activity in EL4 cells.
Thymoma
Protein kinase C isozyme expression in phorbol ester-sensitive and -resistant EL4 thymoma cells.
Thymoma
Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes.
Thymoma
Proteolytic degradation of protein kinase C in the phorbol ester-induced interleukin-2 secreting thymoma cells.
Thymoma
Selective up-regulation of protein kinase C eta in phorbol ester-sensitive versus -resistant EL4 mouse thymoma cells.
Thymoma
Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction.
Thyroid Cancer, Papillary
Acute expression of RET/PTC induces isozyme-specific activation and subsequent downregulation of PKCepsilon in PCCL3 thyroid cells.
Thyroid Cancer, Papillary
Growth-associated protein 43 promotes thyroid cancer cell lines progression via epithelial-mesenchymal transition.
Thyroid Cancer, Papillary
Silencing circRNA protein kinase C iota (circ-PRKCI) suppresses cell progression and glycolysis of human papillary thyroid cancer through circ-PRKCI/miR-335/E2F3 ceRNA axis.
Thyroid Cancer, Papillary
[Growth and invasion of differentiated thyroid gland carcinoma: importance of signal transduction]
Thyroid Neoplasms
Activation of Protein Kinase C delta Induces Growth Arrest in NPA Thyroid Cancer Cells Through Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase.
Thyroid Neoplasms
Assessment of protein kinase C isozymes by enzyme immunoassay and overexpression of type II in thyroid adenocarcinoma.
Thyroid Neoplasms
Ectopic expression of a mutant form of PKCalpha originally found in human tumors: aberrant subcellular translocation and effects on growth control.
Thyroid Neoplasms
Effects of the putatively oncogenic protein kinase Calpha D294G mutation on enzymatic activity and cell growth and its occurrence in human thyroid neoplasias.
Thyroid Neoplasms
Increased plasminogen activator and type IV collagenase activity in invasive follicular thyroid carcinoma cells.
Thyroid Neoplasms
Intercellular adhesion molecule-1 is upregulated via the protein kinase C pathway in human thyroid carcinoma cell lines.
Thyroid Neoplasms
Invasion of metastatic human follicular thyroid cancer is inhibited via antagonism of protein kinase C.
Thyroid Neoplasms
Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis.
Thyroid Neoplasms
Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.
Thyroid Neoplasms
Protein Kinase C: A Putative New Target for the Control of Human Medullary Thyroid Carcinoma Cell Proliferation in Vitro.
Thyroid Neoplasms
S1P1 and VEGFR-2 form a signaling complex with extracellularly regulated kinase 1/2 and protein kinase C-alpha regulating ML-1 thyroid carcinoma cell migration.
Thyroid Neoplasms
Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2.
Thyroid Neoplasms
Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis.
Thyroid Neoplasms
Suppression of thyrotropin receptor-G protein-phospholipase C coupling by activation of protein kinase C in thyroid carcinoma cells.
Thyroid Neoplasms
Tamoxifen antagonizes proliferation and invasion of estrogen receptor-negative metastatic follicular thyroid cancer cells via protein kinase C.
Thyroid Neoplasms
The Importance of Caveolin-1 as Key-Regulator of Three-Dimensional Growth in Thyroid Cancer Cells Cultured under Real and Simulated Microgravity Conditions.
Thyroid Neoplasms
The natural protein kinase C alpha mutant is present in human thyroid neoplasms.
Thyroiditis, Autoimmune
Elevation of protein kinase C in thyrocytes isolated from a Lewis rat model of autoimmune thyroiditis prevents assembly of immunodetectable connexin43 gap junctions and reduces intercellular communication.
Tics
Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway.
Tooth Diseases
Myelin protein zero/P0 phosphorylation and function require an adaptor protein linking it to RACK1 and PKC alpha.
Transfusion-Related Acute Lung Injury
Activation of platelet protein kinase C by ultraviolet light B mediates platelet transfusion-related acute lung injury in a two-event animal model.
Trauma, Nervous System
Activation of protein kinase CbetaI constitutes a new neurotrophic pathway for deafferented spiral ganglion neurons.
Triple Negative Breast Neoplasms
Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy.
Triple Negative Breast Neoplasms
MicroRNA-31 Sensitizes Human Breast Cells to Apoptosis by Direct Targeting of Protein Kinase C {epsilon} (PKC{epsilon}).
Triple Negative Breast Neoplasms
MZF-1/Elk-1 interaction domain as therapeutic target for protein kinase C?-based triple-negative breast cancer cells.
Triple Negative Breast Neoplasms
PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim.
Triple Negative Breast Neoplasms
Protein kinase C ? is involved in the regulation of AXL receptor tyrosine kinase expression in triple-negative breast cancer cells.
Triple Negative Breast Neoplasms
Protein kinase C inhibitor chelerythrine selectively inhibits proliferation of triple-negative breast cancer cells.
Tuberculosis
Activation of protein kinase C by mycobacterial cord factor, trehalose 6-monomycolate, resulting in tumor necrosis factor-alpha release in mouse lung tissues.
Tuberculosis
Activation of the Wnt Pathway by Mycobacterium tuberculosis: A Wnt-Wnt Situation.
Tuberculosis
Arabinosylated lipoarabinomannan (Ara-LAM) mediated intracellular mechanisms against tuberculosis infection: Involvement of protein kinase C (PKC) mediated signaling.
Tuberculosis
CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production.
Tuberculosis
Downregulation of protein kinase C-alpha enhances intracellular survival of Mycobacteria: role of PknG.
Tuberculosis
Impaired generation of reactive oxygen species during differentiation of dendritic cells (DCs) by Mycobacterium tuberculosis secretory antigen (MTSA) and subsequent activation of MTSA-DCs by mycobacteria results in increased intracellular survival.
Tuberculosis
Involvement of TNF-alpha changes in human cancer development, prevention and palliative care.
Tuberculosis
Mycobacterium tuberculosis lipoprotein-induced association of TLR2 with protein kinase C zeta in lipid rafts contributes to reactive oxygen species-dependent inflammatory signalling in macrophages.
Tuberculosis
Protein kinase C-delta (PKC?), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice.
Tuberous Sclerosis
TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts.
Uremia
Translocation of protein kinase C in human platelets by patients with chronic uremia.
Ureteral Obstruction
Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats.
Urinary Bladder Neck Obstruction
Obstruction enhances rho-kinase pathway and diminishes protein kinase C pathway in carbachol-induced calcium sensitization in contraction of ?-toxin permeabilized guinea pig detrusor smooth muscle.
Urinary Bladder Neck Obstruction
Partial bladder outlet obstruction selectively abolishes protein kinase C induced contraction of rabbit detrusor smooth muscle.
Urinary Bladder Neck Obstruction
Role of Rho-kinase and protein kinase C during contraction of hypertrophic detrusor in mice with partial urinary bladder outlet obstruction.
Urinary Bladder Neck Obstruction
Spontaneous and evoked contractions are regulated by PKC-mediated signaling in detrusor smooth muscle: involvement of BK channels.
Urinary Bladder Neoplasms
Genome-wide analysis of DHEA- and DHT-induced gene expression in mouse hypothalamus and hippocampus.
Urinary Bladder Neoplasms
Patterns of protein kinase C isoenzyme expression in transitional cell carcinoma of bladder. Relation to degree of malignancy.
Urinary Bladder Neoplasms
PKC? and Netrin-1/UNC5B positive feedback control in relation with chemical therapy in bladder cancer.
Urinary Bladder Neoplasms
Protein kinase C (PKC) isoenzymes immunohistochemistry in lymph node revealing solution-fixed, paraffin-embedded bladder tumors.
Urinary Bladder Neoplasms
Protein kinase C is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in human bladder cancer cells.
Urinary Bladder Neoplasms
Reduction of protein kinase C ? (PKC-?) promote apoptosis via down-regulation of Dicer in bladder cancer.
Urinary Bladder Neoplasms
Specific sequences of fibronectin activate the protein kinase C signal transduction pathway in invasive bladder cancer.
Urticaria
Critical Signaling Events in the Mechanoactivation of Human Mast Cells through p.C492Y-ADGRE2.
Uterine Cervical Neoplasms
Discovery of cyclin-dependent kinase inhibitor, CR229, using structurebased drug screening.
Uterine Cervical Neoplasms
Involvement of PKC-alpha in regulatory volume decrease responses and activation of volume-sensitive chloride channels in human cervical cancer HT-3 cells.
Uterine Cervical Neoplasms
Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells.
Uterine Cervical Neoplasms
Multimodality therapy: radiation and continuous concomitant cis-platinum and PKC inhibition in a cervical carcinoma model.
Uterine Cervical Neoplasms
Over-expression of protein kinase C?isoforms (?, ?, ? and ?) in squamous cervical cancer.
Uterine Cervical Neoplasms
PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells.
Uterine Cervical Neoplasms
Protein kinase C ? inhibits autophagy and sensitizes cervical cancer Hela cells to cisplatin.
Uterine Cervical Neoplasms
Protein kinase C modulates telomerase activity in human cervical cancer cells.
Uterine Cervical Neoplasms
The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer.
Uterine Neoplasms
Enhancement of growth-promoting activity in extract from uterine cancers by protein kinase C in human endometrial fibroblasts.
Uveitis
Protein kinase Czeta (PKCzeta) regulates ocular inflammation and apoptosis in endotoxin-induced uveitis (EIU): signaling molecules involved in EIU resolution by PKCzeta inhibitor and interleukin-13.
Vaccinia
Production of a non-functional nef protein in human immunodeficiency virus type 1-infected CEM cells.
Vaccinia
Protein kinase C {delta} regulates vaccinia related kinase 1 in DNA damage induced apoptosis.
Vaccinia
Protein kinase Calpha promotes apoptotic cell death in gastric cancer cells depending upon loss of anchorage.
Vascular Calcification
Protein kinase C regulates vascular calcification via cytoskeleton reorganization and osteogenic signaling.
Vascular Diseases
AGER1 regulates endothelial cell NADPH oxidase-dependent oxidant stress via PKC-delta: implications for vascular disease.
Vascular Diseases
Differential roles of PKCalpha and PKCvarepsilon in controlling the gene expression of Nox4 in human endothelial cells.
Vascular Diseases
Peroxide generation by p47phox-Src activation of Nox2 has a key role in protein kinase C-induced arterial smooth muscle contraction.
Vascular Diseases
Protein kinase C activation and its pharmacological inhibition in vascular disease.
Vascular Diseases
Protein Kinase C Inhibitors as Modulators of Vascular Function and their Application in Vascular Disease.
Vascular Ring
Activation of protein kinase C as a modulator of potentiated UK-14304-induced contractions in dog mesenteric artery and vein.
Vascular Ring
Melatonin-induced relaxation of rat aorta: interaction with adrenergic agonists.
Vascular Ring
Protein kinase C modulates receptor-independent activation of endothelial nitric oxide synthase.
Vascular System Injuries
Central role of PKCbeta in neointimal expansion triggered by acute arterial injury.
Vascular System Injuries
Effect of Activated Protein Kinase C Beta Type Mediated Phosphorylation of Signal Transducer and Activator of Transcription 4 on Proliferation and Phenotypic Transformation of Vascular Smooth Muscle Cells After Vascular Injury Induced by Nano-SiO?.
Vascular System Injuries
Essential role of PKC-{zeta} in normal and angiotensin II-accelerated neointimal growth after vascular injury.
Vascular System Injuries
Generation of neutrophil chemotactic activity by phorbol ester-stimulated calf pulmonary artery endothelial cells.
Vascular System Injuries
Novel Paracrine Functions of Smooth Muscle Cells in Supporting Endothelial Regeneration Following Arterial Injury.
Vascular System Injuries
PKCtheta is required for hemostasis and positive regulation of thrombin-induced platelet aggregation and alpha-granule secretion.
Vascular System Injuries
Reduction of PKCbetaII activity in smooth muscle cells attenuates acute arterial injury.
Vascular System Injuries
The Ca2+-dependent isozymes of protein kinase C are uniquely important in the enhanced growth of immature adventitial fibroblasts isolated from the bovine pulmonary arterial wall at a time of heightened susceptibility to vascular injury.
Vascular System Injuries
Transcription factor and kinase-mediated signaling in atherosclerosis and vascular injury.
Vascular System Injuries
[Epidemiology, pathogenesis and therapy of diabetic retinopathy and maculopathy]
Vasospasm, Intracranial
Alterations in protein kinase C activity and membrane lipid metabolism in cerebral vasospasm after subarachnoid hemorrhage.
Vasospasm, Intracranial
Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain.
Vasospasm, Intracranial
Co-expression/co-location of S100 proteins (S100B, S100A1 and S100A2) and protein kinase C (PKC-beta, -eta and -zeta) in a rat model of cerebral basilar artery vasospasm.
Vasospasm, Intracranial
Effects of inhibitors of protein kinase C and calpain in experimental delayed cerebral vasospasm.
Vasospasm, Intracranial
Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm.
Vasospasm, Intracranial
In vitro evidence of the role of hemoglobin during vasospasm on the modifications of the expression of PKCalpha and zeta.
Vasospasm, Intracranial
Inhibition of protein kinase C signal reduces ET receptor expression and basilar vasospasm after subarachnoid hemorrhage in rats.
Vasospasm, Intracranial
Interactive role of protein kinase C-delta with rho-kinase in the development of cerebral vasospasm in a canine two-hemorrhage model.
Vasospasm, Intracranial
Interactive role of tyrosine kinase, protein kinase C, and Rho/Rho kinase systems in the mechanotransduction of vascular smooth muscles.
Vasospasm, Intracranial
Possible mechanism to induce protein kinase C-dependent arterial smooth muscle contraction after subarachnoid haemorrhage.
Vasospasm, Intracranial
Possible role of protein kinase C-dependent smooth muscle contraction in the pathogenesis of chronic cerebral vasospasm.
Vasospasm, Intracranial
Protein kinase C and diacylglycerol content in basilar arteries during experimental cerebral vasospasm in the dog.
Vasospasm, Intracranial
Protein kinase C has two different major roles in lattice compaction enhanced by cerebrospinal fluid from patients with subarachnoid hemorrhage.
Vasospasm, Intracranial
Role of protein kinase C in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage.
Vasospasm, Intracranial
Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C.
Vasospasm, Intracranial
The effects of papaverine on phorbol dibutyrate-induced vasoconstriction in brain slice microvessels.
Vasospasm, Intracranial
Thromboxane A2 synthetase inhibitor failed to ameliorate the arterial narrowing during the chronic phase of cerebral vasospasm.
Vasospasm, Intracranial
Various pathogenetic factors revolving around the central role of protein kinase C activation in the occurrence of cerebral vasospasm
Ventricular Dysfunction
Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy.
Ventricular Dysfunction, Left
Effect of angiotensin II type 2 receptor blockade on activation of mitogen-activated protein kinases after ischemia-reperfusion in isolated working rat hearts.
Ventricular Dysfunction, Left
PKC-{varepsilon}-dependent survival signals in diabetic hearts.
Ventricular Fibrillation
Dietary omega-3 fatty acids attenuate myocardial arrhythmogenic factors and propensity of the heart to lethal arrhythmias in a rodent model of human essential hypertension.
Ventricular Fibrillation
Ischemia-induced ventricular fibrillation in isolated perfused rat heart: role of alpha1A-adrenoceptor mediated activation of protein kinase C.
Ventricular Fibrillation
Melatonin attenuates hypertension-related proarrhythmic myocardial maladaptation of connexin-43 and propensity of the heart to lethal arrhythmias.
Ventricular Fibrillation
Phorbol ester-induced ventricular fibrillation in the Langendorff-perfused rabbit heart: antagonism by staurosporine and glibenclamide.
Ventricular Premature Complexes
The antiarrhythmic effect of centrally administered rilmenidine involves muscarinic receptors, protein kinase C and mitochondrial signalling pathways.
Vertigo
MicroRNA-219a-5p-mediated inhibition of CaMKII? facilitates vestibular compensation in acute vertigo by promoting protein kinase C expression.
Vesicular Stomatitis
Atypical protein kinase C plays a critical role in protein transport from pre-Golgi intermediates.
Vesicular Stomatitis
Inositol phospholipid turnover and protein kinase C translocation are stimulated by poly(I).poly(C) in human amnion cells (UAC).
Vesicular Stomatitis
Rapid enhancement of beta 2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187.
Virus Diseases
Acquired immunodeficiency in murine lymphoproliferative disease: considerations on pathogenesis.
Virus Diseases
Bryostatin activates HIV-1 latent expression in human astrocytes through a PKC and NF-?B-dependent mechanism.
Virus Diseases
Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner.
Virus Diseases
Differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase C epsilon and delta in neonatal rat ventricular myocytes.
Virus Diseases
Early signal transduction in measles virus-infected lymphocytes is unaltered, but second messengers activate virus replication.
Virus Diseases
Effect of persistent measles virus infection on protein kinase C activity and c-fos protooncogene expression in neuroblastoma cells.
Virus Diseases
Entry of influenza viruses into cells is inhibited by a highly specific protein kinase C inhibitor.
Virus Diseases
H2O2 alters rat cardiac sarcomere function and protein phosphorylation through redox signaling.
Virus Diseases
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity.
Virus Diseases
PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and ?-catenin.
Virus Diseases
PKC? is required for porcine reproductive and respiratory syndrome virus replication.
Virus Diseases
RACK1 is indispensable for porcine reproductive and respiratory syndrome virus replication and NF-?B activation in Marc-145 cells.
Virus Diseases
Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase.
Virus Diseases
Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon.
Visna
Inhibition of lymphoproliferation and protein kinase C by synthetic peptides with sequence identity to the transmembrane and Q proteins of visna virus.
Vitamin D Deficiency
1,25-Dihydroxyvitamin D3 and 12-O-tetradecanoyl phorbol 13-acetate cause differential activation of Ca(2+)-dependent and Ca(2+)-independent isoforms of protein kinase C in rat colonocytes.
Vitamin D Deficiency
Interactions between and Shared Molecular Mechanisms of Diabetic Peripheral Neuropathy and Obstructive Sleep Apnea in Type 2 Diabetes Patients.
Vitreoretinopathy, Proliferative
Inhibition of experimental proliferative vitreoretinopathy with protein kinase C inhibitor (chelerythrine chloride) and melatonin.
Vitreoretinopathy, Proliferative
The inhibition of CA2+ influx induced by hypericin in cultured human retinal pigment epithelial cells analyzed by confocal imaging.
Vitreoretinopathy, Proliferative
The inhibitory effect of small interference RNA protein kinase C-alpha on the experimental proliferative vitreoretinopathy induced by dispase in mice.
von Willebrand Diseases
Protein kinase C signaling dysfunction in von Willebrand disease (p.V1316M) type 2B platelets.
Waldenstrom Macroglobulinemia
Novel agents in the treatment of Waldenström's macroglobulinemia.
Waldenstrom Macroglobulinemia
Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia.
Warts
PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.
Whooping Cough
5'-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes.
Whooping Cough
5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools.
Whooping Cough
?-Opioid receptors stimulate the metabolic sensor AMP-activated protein kinase through coincident signaling with G(q/11)-coupled receptors.
Whooping Cough
A comparison of the effects of signal transduction inhibitors on oxidative burst and degranulation in IL-I beta stimulated bovine neutrophils.
Whooping Cough
A functional assay to measure postsynaptic gamma-aminobutyric acidB responses in cultured spinal cord neurons: heterologous regulation of the same K+ channel.
Whooping Cough
A novel mechanism of action of corticotropin releasing factor in rat Leydig cells.
Whooping Cough
A novel signaling pathway for beta-adrenergic receptor-mediated activation of phosphoinositide 3-kinase in H9c2 cardiomyocytes.
Whooping Cough
A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1.
Whooping Cough
A protein kinase C inhibitor, staurosporine, activates phospholipase D via a pertussis toxin-sensitive GTP-binding protein in rabbit peritoneal neutrophils.
Whooping Cough
Acetylcholine stimulates cortical precursor cell proliferation in vitro via muscarinic receptor activation and MAP kinase phosphorylation.
Whooping Cough
Activation and proliferation signals in murine macrophages. Biochemical signals controlling the regulation of macrophage urokinase-type plasminogen activator activity by colony-stimulating factors and other agents.
Whooping Cough
Activation of a K+ conductance by bradykinin and by inositol-1,4,5-trisphosphate in rat glioma cells: involvement of intracellular and extracellular Ca2+.
Whooping Cough
Activation of a muscarinic receptor selectively inhibits a rapidly inactivated Ca2+ current in rat sympathetic neurons.
Whooping Cough
Activation of G(i) induces mechanical hyperalgesia poststress or inflammation.
Whooping Cough
Activation of growth hormone secretagogue type 1a receptor inhibits T-type Ca2+ channel currents through pertussis toxin-sensitive novel protein kinase C pathway in mouse spermatogenic cells.
Whooping Cough
Activation of heat shock protein (hsp)70 and proto-oncogene expression by alpha1 adrenergic agonist in rat aorta with age.
Whooping Cough
Activation of human neutrophils by chlordane: induction of superoxide production and phagocytosis but not chemotaxis or apoptosis.
Whooping Cough
Activation of M3 muscarinic receptors inhibits T-type Ca(2+) channel currents via pertussis toxin-sensitive novel protein kinase C pathway in small dorsal root ganglion neurons.
Whooping Cough
Activation of MAP kinase by the LHRH receptor through a dual mechanism involving protein kinase C and a pertussis toxin-sensitive G protein.
Whooping Cough
Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary response gene Krox-24.
Whooping Cough
Activation of mitogen-activated protein kinase in BC3H1 myocytes by fluoroaluminate.
Whooping Cough
Activation of neutrophils by interleukins-1 and -2 and tumor necrosis factors.
Whooping Cough
Activation of PKCbeta(II) and PKCtheta is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation.
Whooping Cough
Activation of protein kinase C by oxytocin inhibits the biological activity of the human myometrial corticotropin-releasing hormone receptor at term.
Whooping Cough
Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via pathways that require Galpha(q) and Galpha(o) function.
Whooping Cough
Activation of type II adenylate cyclase by D2 and D4 but not D3 dopamine receptors.
Whooping Cough
Activators of protein kinase C selectively enhance inactivation of a calcium current component of cultured sensory neurons in a pertussis toxin-sensitive manner.
Whooping Cough
Adenosine 5'-triphosphate, phorbol ester, and pertussis toxin effects on atrial natriuretic peptide stimulation of guanylate cyclase in a human renal cell line.
Whooping Cough
Adenosine A1 receptor-induced upregulation of protein kinase C: role of pertussis toxin-sensitive G protein(s).
Whooping Cough
Adenosine attenuates oxidant injury in human proximal tubular cells via A(1) and A(2a) adenosine receptors.
Whooping Cough
Adenosine evokes potassium currents by protein kinase C activated via a novel signaling pathway in superior colliculus neurons.
Whooping Cough
Adenosine receptor-induced cAMP changes in D384 astrocytoma cells and the effect of bradykinin thereon.
Whooping Cough
Agonist-specific alterations in receptor-phospholipase coupling following inactivation of Gi2alpha gene.
Whooping Cough
Alpha 2A-adrenergic receptors activate protein kinase C in human platelets via a pertussis toxin-sensitive G-protein.
Whooping Cough
alpha(2B)-Adrenergic receptors activate MAPK and modulate proliferation of primary cultured proximal tubule cells.
Whooping Cough
Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses.
Whooping Cough
Angiotensin AT(1) receptor phosphorylation and desensitization in a hepatic cell line. Roles of protein kinase c and phosphoinositide 3-kinase.
Whooping Cough
Angiotensin II type 1 receptor activation modulates L- and T-type calcium channel activity through distinct mechanisms in bovine adrenal glomerulosa cells.
Whooping Cough
Angiotensin II-induced oxidative burst is fluvastatin sensitive in neutrophils of patients with hypercholesterolemia.
Whooping Cough
Angiotensin II-induced protein tyrosine phosphorylation in neonatal rat cardiac fibroblasts.
Whooping Cough
Antiproliferative effect of sphingosylphosphorylcholine in thyroid FRO cancer cells mediated by cell cycle arrest in the G2/M phase.
Whooping Cough
Apolipoprotein CIII-induced THP-1 cell adhesion to endothelial cells involves pertussis toxin-sensitive G protein- and protein kinase C alpha-mediated nuclear factor-kappaB activation.
Whooping Cough
Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells.
Whooping Cough
Augmentation of calcium channel currents in response to G protein activation by GTP gamma S in chick sensory neurons.
Whooping Cough
beta-Migrating very low density lipoprotein (beta VLDL) activates smooth muscle cell mitogen-activated protein (MAP) kinase via G protein-coupled receptor-mediated transactivation of the epidermal growth factor (EGF) receptor: effect of MAP kinase activation on beta VLDL plus EGF-induced cell proliferation.
Whooping Cough
Bombesin enhancement of cAMP accumulation in Swiss 3T3 cells: evidence of a dual mechanism of action.
Whooping Cough
Bombesin stimulation of mitogenesis. Specific receptors, signal transduction, and early events.
Whooping Cough
Bradykinin B2 receptors activate Na+/H+ exchange in mIMCD-3 cells via Janus kinase 2 and Ca2+/calmodulin.
Whooping Cough
Bradykinin-induced generation of inositol 1,4,5-trisphosphate in fibroblasts and neuroblastoma cells: effect of pertussis toxin, extracellular calcium, and down-regulation of protein kinase C.
Whooping Cough
Ca(2+)-dependent and -independent mechanism of cyclic-AMP reduction: mediation by bradykinin B2 receptors.
Whooping Cough
Ca(2+)-inactivated K+ current is modulated by endothelin-1 in B-16 murine melanoma cells.
Whooping Cough
Ca2+ inhibition of beta-adrenergic receptor- and forskolin-stimulated cAMP accumulation in C6-2B rat glioma cells is independent of protein kinase C.
Whooping Cough
Calcium mobilization and cell proliferation activated by extracellular ATP in human ovarian tumour cells.
Whooping Cough
Calcium-sensing receptor modulates extracellular Ca2+ entry via TRPC-encoded receptor-operated channels in human aortic smooth muscle cells.
Whooping Cough
Carbachol-induced actin reorganization involves Gi activation of Rho in human airway smooth muscle cells.
Whooping Cough
Celecoxib simulates respiratory burst through pertussis toxin-sensitive G-protein, a possible signal for beta 2-integrin expression on human neutrophils.
Whooping Cough
Characterization of lysophosphatidic acid and sphingosine-1-phosphate-mediated signal transduction in rat cortical oligodendrocytes.
Whooping Cough
Cholinergic-induced [3H] noradrenaline release in rat brain cortical slices is mediated via a pertussis toxin sensitive GTP binding protein and involves activation of protein kinase C.
Whooping Cough
Collagen type IV stimulates an increase in intracellular Ca2+ in pancreatic acinar cells via activation of phospholipase C.
Whooping Cough
Comparison of the actions of baclofen at pre- and postsynaptic receptors in the rat hippocampus in vitro.
Whooping Cough
Conformational dependence of collagenase (matrix metalloproteinase-1) up-regulation by elastin peptides in cultured fibroblasts.
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Contribution of cAMP to the inhibitory effect of non-steroidal anti-inflammatory drugs in rat uterine smooth muscle.
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Contribution of extracellular signal-regulated kinase to UTP-induced interleukin-6 biosynthesis in HaCaT keratinocytes.
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Coupling of 5-HT1A autoreceptors to inhibition of mitogen-activated protein kinase activation via G beta gamma subunit signaling.
Whooping Cough
Critical Signaling Events in the Mechanoactivation of Human Mast Cells through p.C492Y-ADGRE2.
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Cross-talk among epidermal growth factor, Ap(5)A, and nucleotide receptors causing enhanced ATP Ca(2+) signaling involves extracellular kinase activation in cerebellar astrocytes.
Whooping Cough
Crystal-induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystals.
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D-2-amino-5-phosphonopentanoic acid inhibits intrathecal pertussis toxin-induced thermal hyperalgesia and protein kinase Cgamma up-regulation.
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D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells.
Whooping Cough
Depolarization of polymorphonuclear leukocytes by Porphyromonas (Bacteroides) gingivalis 381 in the absence of respiratory burst activation.
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Differences between presynaptic and postsynaptic GABAB mechanisms in rat hippocampal pyramidal cells.
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Different sensitivity to phorbol esters and pertussis toxin of bombesin- and platelet-derived growth factor-induced, phospholipase C-mediated hydrolysis of phosphoinositides in NIH/3T3 cells.
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Differential activation of signal transduction pathways mediating oxidative burst by chicken heterophils in response to stimulation with lipopolysaccharide and lipoteichoic acid.
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Differential calcium regulation of proinflammatory activities in human neutrophils exposed to the neuropeptide pituitary adenylate cyclase-activating protein.
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Differential roles of protein kinase C and pertussis toxin-sensitive G-binding proteins in modulation of melanoma cell proliferation and motility by thrombospondin 1.
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Direct activation of second messenger pathways mimics cell adhesion molecule-dependent neurite outgrowth.
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Direct and biochemical interaction between dopamine D3 receptor and elongation factor-1Bbetagamma.
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Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal.
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Dual effect of thrombin on voltage-dependent Ca2+ channels of portal vein smooth muscle cells.
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Duality of the voltage-dependent calcium influx in adrenal glomerulosa cells.
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Effect of inhibitors of distinct signalling pathways on neutrophil Q2- generation in response to tumor necrosis factor-alpha, and antibodies against CD18 and CD11a: evidence for a common and unique pattern of sensitivity to wortmannin and protein tyrosine kinase inhibitors.
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Effect of protein kinase C inhibitor (H-7) and calmodulin antagonist (W-7) on pertussis toxin-induced IL-1 production by human adherent monocytes. Comparison with lipopolysaccharide as a stimulator of IL-1 production.
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Effect of retinoic acid on prostaglandin F2 alpha-induced phospholipase D activity in osteoblast-like cells.
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Effect of retinoic acid on prostaglandin F2 alpha-induced prostaglandin E2 synthesis in osteoblast-like cells.
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Effect of tumor necrosis factor-alpha on the stimulus-coupled responses of neutrophils and their modulation by various inhibitors.
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Effects of angiotensin II on the action potential durations of atrial myocytes in hypertensive rats.
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Effects of chronic receptor blockade on excitation-contraction coupling in rat aortic rings.
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Effects of prostaglandin E2 on amiloride-blockable Na+ channels in a distal nephron cell line (A6).
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Effects of protein kinase C activation on cyclic AMP and testosterone production of rat Leydig cells in vitro.
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Efficient neutrophil extracellular trap induction requires mobilization of both intracellular and extracellular calcium pools and is modulated by cyclosporine A.
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Emodin augments calcium activated chloride channel in colonic smooth muscle cells by Gi/Go protein.
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Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A: involvement of the wnt/glycogen synthase kinase-3 beta pathway.
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Endothelin B receptor mediates ET-1 effects on cAMP and PGE2 accumulation in rat IMCD.
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Endothelin inhibits vasopressin-stimulated water permeability in rat terminal inner medullary collecting duct.
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Endothelin-1 activates mitogen-activated protein kinases through two independent signalling pathways in rat astrocytes.
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Endothelin-1 induces rapid and long lasting internalization of the thrombin receptor in human glomerular epithelial cells.
Whooping Cough
Endothelin-1 receptor binding and cellular signal transduction in cultured human brain endothelial cells.
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Endothelin-1 stimulates the release of arachidonic acid and prostaglandins in cultured human ciliary muscle cells: activation of phospholipase A2.
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Endothelin-1 suppression of rat adipocyte precursor cell differentiation in serum-free culture.
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Endothelin-mediated vascular growth requires p42/p44 mitogen-activated protein kinase and p70 S6 kinase cascades via transactivation of epidermal growth factor receptor.
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Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied by their association with cytoskeletal components.
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Enhancement of lysophosphatidic acid-induced ERK phosphorylation by phospholipase D1 via the formation of phosphatidic acid.
Whooping Cough
Epidermal growth factor enhances glomerular mesangial cell soluble phospholipase A2 activity.
Whooping Cough
Epidermal growth factor-stimulated phosphoinositide hydrolysis in cultured rat inner medullary collecting tubule cells. Regulation by G protein, calcium, and protein kinase C.
Whooping Cough
Evidence for a cyclic AMP-dependent pathway in angiotensin AT1-receptor activation of human omental arteries.
Whooping Cough
Evidence for participation of calcineurin in potentiation of agonist-stimulated cyclic AMP formation by the calcium-mobilizing hormone, angiotensin II.
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Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation.
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Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells.
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Extracellular ATP stimulates polyphosphoinositide hydrolysis and prostaglandin synthesis in rat renal mesangial cells. Involvement of a pertussis toxin-sensitive guanine nucleotide binding protein and feedback inhibition by protein kinase C.
Whooping Cough
Functional characterization of the Na(+)-H+ exchanger in rat mast cells: crosstalks between different kinase pathways.
Whooping Cough
Further characterization of 5-HT- and 5-HT3 receptor agonists'-stimulated phosphoinositol phosphates accumulation.
Whooping Cough
G proteins and phospholipase C mediate thrombin-induced generation of plasminogen activator inhibitor-1 from vascular smooth muscle cells.
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G-protein beta gamma subunits mediate specific phosphorylation of the protein-tyrosine phosphatase SH-PTP1 induced by lysophosphatidic acid.
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Gi- and protein kinase C-mediated heterologous potentiation of phospholipase C signaling by G protein-coupled receptors.
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Gi-mediated activation of the p42/p44 mitogen-activated protein kinases by receptor mimetic basic secretagogues is abrogated by inhibitors of endocytosis.
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GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain.
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Group I secreted PLA2 in the maintenance of human lower esophageal sphincter tone.
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Guanine nucleotides stimulate NADPH oxidase in membranes of human neutrophils.
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Guinea pig histamine H1 receptor. II. Stable expression in Chinese hamster ovary cells reveals the interaction with three major signal transduction pathways.
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Halothane inhibits bradykinin-stimulated prostacyclin production in endothelial cells.
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Heterotrimeric G proteins involved in the modulation of voltage-dependent calcium channels of neuroendocrine cells.
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High concentrations of histamine stimulate equine polymorphonuclear neutrophils to produce reactive oxygen species.
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High density lipoprotein-induced signaling of the MAPK pathway involves scavenger receptor type BI-mediated activation of Ras.
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High-density lipoprotein induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through sphingosine kinase-2.
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Hormonal regulation of mitogen-activated protein kinase activity in bovine adrenocortical cells: cross-talk between phosphoinositides, adenosine 3',5'-monophosphate, and tyrosine kinase receptor pathways.
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Human eotaxin represents a potent activator of the respiratory burst of human eosinophils.
Whooping Cough
Human monocytes respond to leukotriene B4 with a transient increase in cytosolic calcium.
Whooping Cough
In vitro activation of murine peritoneal macrophages by monocyte chemoattractant protein-1: upregulation of CD11b, production of proinflammatory cytokines, and the signal transduction pathway.
Whooping Cough
Increased proliferation of adventitial fibroblasts from spontaneously hypertensive rat aorta.
Whooping Cough
Induction of c-fos proto-oncogene by a chemotactic peptide in human peripheral granulocytes.
Whooping Cough
Induction of c-jun independent of PKC, pertussis toxin-sensitive G protein, and polyamines in quiescent SV40-transformed 3T3 T cells.
Whooping Cough
Inflammatory and contractile agents sensitize specific adenylyl cyclase isoforms in human airway smooth muscle.
Whooping Cough
Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression.
Whooping Cough
Inhibition of alpha(1)-adrenergic-mediated responses in rat ventricular myocytes by adenosine A(1) receptor activation: role of the K(ATP) channel.
Whooping Cough
Inhibition of bombesin-induced mitogenesis by pertussis toxin: dissociation from phospholipase C pathway.
Whooping Cough
Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1).
Whooping Cough
Inhibition of cAMP accumulation by intracellular calcium mobilization in C6-2B cells stably transfected with substance K receptor cDNA.
Whooping Cough
Inhibition of epithelial Na+ transport by atriopeptin, protein kinase c, and pertussis toxin.
Whooping Cough
Inhibition of tumor necrosis factor-induced p42/p44 mitogen-activated protein kinase activation by sodium salicylate.
Whooping Cough
Insulin-like growth factor-I induces alpha(1B)-adrenergic receptor phosphorylation through G beta gamma and epidermal growth factor receptor transactivation.
Whooping Cough
Insulin-stimulated phosphatidylcholine hydrolysis, diacylglycerol/protein kinase C signalling, and hexose transport in pertussis toxin-treated BC3H-1 myocytes.
Whooping Cough
Interactive effects of pertussis toxin and the phorbol ester tumour promotor, phorbol dibutyrate, on T-lymphocyte mitogenesis and the expression of phenotypic determinants.
Whooping Cough
Interleukin (IL)-8-induced in vitro human lymphocyte migration is inhibited by cholera and pertussis toxins and inhibitors of protein kinase C.
Whooping Cough
Interleukin-1 beta inhibits Ca2+ channel currents in hippocampal neurons through protein kinase C.
Whooping Cough
Interleukin-8 production induced by the endozepine triakontatetraneuropeptide in human neutrophils: role of calcium and pharmacological investigation of signal transduction pathways.
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Intracellular calcium rise produced by platelet-activating factor is deactivated by fMet-Leu-Phe and this requires uninterrupted activation sequence: role of protein kinase C.
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Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor.
Whooping Cough
Involvement of Gq/11 in both integrin signal-dependent and -independent pathways regulating endothelin-induced neural progenitor proliferation.
Whooping Cough
Involvement of MAP kinases in the control of cPLA(2) and arachidonic acid release in endothelial cells.
Whooping Cough
Involvement of protein kinase C and RhoA in protease-activated receptor 1-mediated F-actin reorganization and cell growth in rat cardiomyocytes.
Whooping Cough
Involvement of Protein Kinase C and RhoA in Protease-Activated Receptor 1-Mediated F-Actin Reorganization and Cell Growth in Rat Cardiomyocytes.
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Involvement of Rho and tyrosine kinase in angiotensin II-induced actin reorganization in mesothelial cells.
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Ischemic preconditioning provides both acute and delayed protection against renal ischemia and reperfusion injury in mice.
Whooping Cough
Isoflurane preconditioning decreases glutamate receptor overactivation-induced Purkinje neuronal injury in rat cerebellar slices.
Whooping Cough
L-channel modulation by alpha-1 adrenoceptor activation in neonatal rat ventricular cells: intracellular mechanisms.
Whooping Cough
Leukotactin-1/CCL15 induces cell migration and differentiation of human eosinophilic leukemia EoL-1 cells through PKCdelta activation.
Whooping Cough
Leukotriene B4 Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation.
Whooping Cough
Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor.
Whooping Cough
Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors.
Whooping Cough
Lithium activates mammalian Na+/H+ exchangers: isoform specificity and inhibition by genistein.
Whooping Cough
Lithium stimulation of rat pancreatic beta-cell replication is mediated through pertussis toxin-sensitive GTP-binding proteins and occurs independently of Ca2+ influx, cAMP, or protein kinase C activation.
Whooping Cough
Localization of IP in rabbit kidney and functional role of the PGI(2)/IP system in cortical collecting duct.
Whooping Cough
Long lasting inhibition of adenylyl cyclase selectively mediated by inositol 1,4,5-trisphosphate-evoked calcium release.
Whooping Cough
Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins.
Whooping Cough
Lysophosphatidic acid activates ?-catenin/T cell factor signaling, which contributes to the suppression of apoptosis in H19-7 cells.
Whooping Cough
Lysophosphatidic acid activates NF-kappaB in fibroblasts. A requirement for multiple inputs.
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Lysophosphatidic acid induces alpha1B-adrenergic receptor phosphorylation through G beta gamma, phosphoinositide 3-kinase, protein kinase C and epidermal growth factor receptor transactivation.
Whooping Cough
Lysophosphatidic acid induction of transforming growth factors alpha and beta: modulation of proliferation and differentiation in cultured human keratinocytes and mouse skin.
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Lysophosphatidic acid mimics serum-induced sensitization of cyclic AMP accumulation.
Whooping Cough
Lysophosphatidic acid modulates alpha(1b)-adrenoceptor phosphorylation and function: roles of Gi and phosphoinositide 3-kinase.
Whooping Cough
Lysophosphatidic acid stimulates protein kinase C isoforms alpha, beta, epsilon, and zeta in a pertussis toxin sensitive pathway in vascular smooth muscle cells.
Whooping Cough
MCP-1 induces inflammatory activation of human tubular epithelial cells: involvement of the transcription factors, nuclear factor-kappaB and activating protein-1.
Whooping Cough
Mechanism and regulation of neutrophil priming by platelet-activating factor.
Whooping Cough
Mechanism of catecholamine-induced proliferation of vascular smooth muscle cells.
Whooping Cough
Mechanism of extracellular ATP-induced proliferation of vascular smooth muscle cells.
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Mechanism of induction of prostaglandin E2 production by endothelin 1 in cultured rat mesangial cells.
Whooping Cough
Mechanism of inhibition of adenylate cyclase by phospholipase C-catalyzed hydrolysis of phosphatidylcholine. Involvement of a pertussis toxin-sensitive G protein and protein kinase C.
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Mechanism of mu-opioid receptor-mediated presynaptic inhibition in the rat hippocampus in vitro.
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Mechanism of N-formyl-methionyl-leucyl-phenylalanine- and platelet-activating factor-induced arachidonic acid release in guinea pig alveolar macrophages: involvement of a GTP-binding protein and role of protein kinase A and protein kinase C.
Whooping Cough
Mechanism of sodium transport inhibition by epidermal growth factor in cortical collecting ducts.
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Mechanisms and modulation of pituitary adenylate cyclase-activating protein-induced calcium mobilization in human neutrophils.
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Mechanisms mediating pituitary adenylate cyclase-activating polypeptide depolarization of rat sympathetic neurons.
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Mechanisms of ischemic preconditioning in rat hearts. Involvement of alpha 1B-adrenoceptors, pertussis toxin-sensitive G proteins, and protein kinase C.
Whooping Cough
Mechanisms of protein kinase D activation in response to P2Y(2) and P2X7 receptors in primary astrocytes.
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Mechanisms through which high glucose concentration raises [Ca2+]i in renal proximal tubular cells.
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Mediation by protein kinases C and A of Go-linked slow responses of enteric neurons to 5-HT.
Whooping Cough
Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways.
Whooping Cough
Membrane signalling and progesterone in female and male osteoblasts. I. Involvement Of intracellular Ca(2+), inositol trisphosphate, and diacylglycerol, but not cAMP.
Whooping Cough
mGluR7 inhibits glutamate release through a PKC-independent decrease in the activity of P/Q-type Ca2+ channels and by diminishing cAMP in hippocampal nerve terminals.
Whooping Cough
Mitogen-induced activation of Na+/H+ exchange in vascular smooth muscle cells involves janus kinase 2 and Ca2+/calmodulin.
Whooping Cough
Mitogen-induced tyrosine phosphorylation of 41 kDa and 43 kDa proteins. Potential role in integrating multiple mitogenic signalling pathways.
Whooping Cough
Mitogenic signaling pathways of growth factors can be distinguished by the involvement of pertussis toxin-sensitive guanosine triphosphate-binding protein and of protein kinase C.
Whooping Cough
Mitogenic signaling via endogenous kappa-opioid receptors in C6 glioma cells: evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascade.
Whooping Cough
Mobilization of intracellular calcium in cultured vascular smooth muscle cells by uridine triphosphate and the calcium ionophore A23187.
Whooping Cough
Modulation of islet G-proteins, alpha-glucosidehydrolase inhibition and insulin release stimulated by various secretagogues.
Whooping Cough
Modulation of protein kinase C isozymes and substrates by lithium: the role of myo-inositol.
Whooping Cough
Molecular determinants and feedback circuits regulating type 2 CRH receptor signal integration.
Whooping Cough
Molecular events involved in the increased expression of matrix metalloproteinase-9 by T lymphocytes of mammary tumor-bearing mice.
Whooping Cough
Molecular mechanisms of lymphocyte extravasation. III. The loss of lymphocyte extravasation potential induced by pertussis toxin is not mediated via the activation of protein kinase C.
Whooping Cough
Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in human smooth muscle cells by differential activation of nuclear factor-kappaB and activator protein-1.
Whooping Cough
Monocyte chemotactic protein 1 amplifies serotonin-induced vascular smooth muscle cell proliferation.
Whooping Cough
Multiple mechanisms of arachidonic acid release in Chinese hamster ovary cells transfected with cDNA of substance P receptor.
Whooping Cough
Multiple mechanisms of bradykinin-induced contraction in rat and guinea pig smooth muscles in vitro.
Whooping Cough
Muscarinic acetylcholine and histamine-receptor mediated calcium mobilization and cell-growth in human ovarian-cancer cells.
Whooping Cough
Muscarinic-induced mucin secretion and intracellular signaling by hamster tracheal goblet cells.
Whooping Cough
N-methyl D-aspartate receptor-mediated bidirectional control of extracellular signal-regulated kinase activity in cortical neuronal cultures.
Whooping Cough
Nefiracetam modulates acetylcholine receptor currents via two different signal transduction pathways.
Whooping Cough
Neuropeptide Y increases 4-aminopyridine-sensitive transient outward potassium current in rat ventricular myocytes.
Whooping Cough
Neurotensin inhibits background K+ channels and facilitates glutamatergic transmission in rat spinal cord dorsal horn.
Whooping Cough
Nociceptin/orphanin FQ activates mitogen-activated protein kinase in Chinese hamster ovary cells expressing opioid receptor-like receptor.
Whooping Cough
Non-genomic action of the mineralocorticoid aldosterone on cytosolic sodium in cultured kidney cells.
Whooping Cough
Nongenomic effect of thyroid hormone on free-radical production in human polymorphonuclear leukocytes.
Whooping Cough
Nongenomic mechanism of glucocorticoid inhibition of bradykinin-induced calcium influx in PC12 cells: possible involvement of protein kinase C.
Whooping Cough
Noradrenaline and alpha-adrenergic signaling induce the hsp70 gene promoter in mollusc immune cells.
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Norepinephrine induces vascular endothelial growth factor gene expression in brown adipocytes through a beta -adrenoreceptor/cAMP/protein kinase A pathway involving Src but independently of Erk1/2.
Whooping Cough
Novel cardiac myofilament desensitizing factor released by endocardial and vascular endothelial cells.
Whooping Cough
Opposite modulation of astroglial proliferation by adenosine 5'-O-(2-thio)-diphosphate tetralithium and 2-methylthioadenosine-5'-diphosphate trisodium: mechanisms involved.
Whooping Cough
Oxidant-mediated activation of cytosolic phospholipase a(2) in pulmonary endothelium: role of protein kinase C alpha and a pertussis toxin-sensitive protein.
Whooping Cough
Oxytocin activates mitogen-activated protein kinase and up-regulates cyclooxygenase-2 and prostaglandin production in human myometrial cells.
Whooping Cough
Oxytocin and lysophosphatidic acid induce stress fiber formation in human myometrial cells via a pathway involving Rho-kinase.
Whooping Cough
P2 Receptor-mediated Inhibition of Vasopressin-stimulated Fluid Transport and cAMP Responses in AQP2-transfected MDCK Cells.
Whooping Cough
Pancreastatin activates protein kinase C by stimulating the formation of 1,2-diacylglycerol in rat hepatocytes.
Whooping Cough
Parathyroid hormone activates mitogen-activated protein kinase in opossum kidney cells.
Whooping Cough
Pasteurella (Mannheimia) haemolytica leukotoxin-induced cytolysis of bovine leukocytes: role of arachidonic acid and its regulation.
Whooping Cough
Permeabilization in a cerebral endothelial barrier model by pertussis toxin involves the PKC effector pathway and is abolished by elevated levels of cAMP.
Whooping Cough
Pertussis but not cholera toxin inhibits the stimulated increase in actin association with the cytoskeleton in rabbit neutrophils: role of the "G proteins" in stimulus-response coupling.
Whooping Cough
Pertussis toxin activates L-arginine uptake in pulmonary endothelial cells through downregulation of PKC-alpha activity.
Whooping Cough
Pertussis toxin activates protein kinase C and a tyrosine protein kinase in the human T cell line Jurkat.
Whooping Cough
Pertussis toxin B-oligomer suppresses human immunodeficiency virus-1 Tat-induced neuronal apoptosis through feedback inhibition of phospholipase C-beta by protein kinase C.
Whooping Cough
Pertussis toxin directly activates endothelial cell p42/p44 MAP kinases via a novel signaling pathway.
Whooping Cough
Pertussis toxin inhibits the FMLP-induced membrane association of protein kinase C in human neutrophils.
Whooping Cough
Pertussis toxin modification of PC12 cells lowers cytoskeletal F-actin and enhances norepinephrine secretion: involvement of protein kinase C and protein phosphatases.
Whooping Cough
Pertussis toxin or phorbol 12-myristate 13-acetate can distinguish between epidermal growth factor- and angiotensin-stimulated signals in hepatocytes.
Whooping Cough
Pertussis toxin stimulates the secretion of [Met5]-enkephalin and the expression of proenkephalin A mRNA in bovine adrenal medullary chromaffin cells.
Whooping Cough
Pertussis toxin-induced lung edema. Role of manganese superoxide dismutase and protein kinase C.
Whooping Cough
Pertussis toxin-sensitive G-protein and protein kinase C activity are involved in normal synapse elimination in the neonatal rat muscle.
Whooping Cough
PGE2 regulates cAMP production in cultured rabbit CCD cells: evidence for dual inhibitory mechanisms.
Whooping Cough
Phorbol ester-induced changes in cytoplasmic Ca2+ in human neutrophils. Involvement of a pertussis toxin-sensitive G protein.
Whooping Cough
Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance.
Whooping Cough
Phosphorylation, desensitization and internalization of human alpha1B-adrenoceptors induced by insulin-like growth factor-I.
Whooping Cough
PKC modulation of inhibitory coupling of angiotensin II receptors with adenylate cyclase in lactotroph cells.
Whooping Cough
Plasmin is a potent and specific chemoattractant for human peripheral monocytes acting via a cyclic guanosine monophosphate-dependent pathway.
Whooping Cough
Platelet-activating factor exerts mitogenic activity and stimulates expression of interleukin 6 and interleukin 8 in human lung fibroblasts via binding to its functional receptor.
Whooping Cough
Platelet-activating factor stimulates phosphoinositide turnover in neurohybrid NCB-20 cells: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins and inhibition by protein kinase C.
Whooping Cough
Platelet-activating factor-mediated synthesis of prostaglandins in rat Kupffer cells.
Whooping Cough
Platelet-derived growth factor mediated altered expression and regulation of ornithine decarboxylase in H-ras-transformed cell lines.
Whooping Cough
Polyphosphoinositide hydrolysis and protein kinase C activation in guinea pig tracheal smooth muscle cells in culture by leukotriene D4 involve a pertussis toxin sensitive G-protein.
Whooping Cough
Porcine pancreatic phospholipase A2 stimulates secretin release from secretin-producing cells.
Whooping Cough
Possible involvement of phosphatidylinositol-specific phospholipase C related to pertussis toxin-sensitive GTP-binding proteins during adipocyte differentiation of 3T3-L1 fibroblasts: negative regulation of protein kinase C.
Whooping Cough
Postsynaptic kainate receptor recycling and surface expression are regulated by metabotropic autoreceptor signalling.
Whooping Cough
Potent activation of multiple signalling pathways by C-peptide in opossum kidney proximal tubular cells.
Whooping Cough
Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells.
Whooping Cough
Potentiation of cyclic adenosine monophosphate production by thrombin in the human erythroleukemia cell line, HEL.
Whooping Cough
Potentiation of NMDA receptor-mediated transmission in turtle cerebellar granule cells by activation of metabotropic glutamate receptors.
Whooping Cough
Presynaptic inhibition of transmitter release from rat sympathetic neurons by bradykinin.
Whooping Cough
Priming by grepafloxacin on respiratory burst of human neutrophils: its possible mechanism.
Whooping Cough
Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein.
Whooping Cough
Prolactin induced production of cytokines in macrophages involves Ca++ and p42/44 MAP kinase signaling pathway.
Whooping Cough
Prostaglandins mediate the defect in AVP-stimulated cAMP generation in immature collecting duct.
Whooping Cough
Prostanoid signaling, localization, and expression of IP receptors in rat thick ascending limb cells.
Whooping Cough
Protease-activated receptor-1 upregulates fibroblast growth factor 7 in stroma of benign prostatic hyperplasia.
Whooping Cough
Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: inhibition by pertussis toxin.
Whooping Cough
Protein kinase C and G(i/o) proteins are involved in adenosine- and ischemic preconditioning-mediated renal protection.
Whooping Cough
Protein kinase C enhances growth hormone releasing factor (1-40)-stimulated cyclic AMP levels in anterior pituitary. Actions of somatostatin and pertussis toxin.
Whooping Cough
Protein kinase C inhibitor chelerythrine attenuates the morphine-induced excitatory amino acid release and reduction of the antinociceptive effect of morphine in rats injected intrathecally with pertussis toxin.
Whooping Cough
Protein kinase C isoforms and A1 adenosine receptors in porcine coronary smooth muscle cells.
Whooping Cough
Protein kinase C stimulates adenylate cyclase activity in prolactin-secreting rat adenoma (GH4C1) pituicytes by inactivating the inhibitory GTP-binding protein Gi.
Whooping Cough
Proteolytic activation of protein kinase Calpha by peroxynitrite in stimulating cytosolic phospholipase A2 in pulmonary endothelium: involvement of a pertussis toxin sensitive protein.
Whooping Cough
Quercetin sensitizes RBL-2H3 cells to polybasic mast cell secretagogues through increased expression of Gi GTP-binding proteins linked to a phospholipase C signaling pathway.
Whooping Cough
Raf-1 kinase activation by angiotensin II in adrenal glomerulosa cells: roles of Gi, phosphatidylinositol 3-kinase, and Ca2+ influx.
Whooping Cough
Rapid Ca2+ influx and diacylglycerol synthesis in growth hormone-mediated islet beta -cell mitogenesis.
Whooping Cough
Rapid elevation of calcium concentration in cultured dorsal spinal cord astrocytes by corticosterone.
Whooping Cough
Rapid inhibitory effects of corticosterone on calcium influx in rat dorsal root ganglion neurons.
Whooping Cough
Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway.
Whooping Cough
Ras/Rac-Dependent activation of p38 mitogen-activated protein kinases in smooth muscle cells stimulated by cyclic strain stress
Whooping Cough
Regeneration of entorhinal fibers in mouse slice cultures is age dependent and can be stimulated by NT-4, GDNF, and modulators of G-proteins and protein kinase C.
Whooping Cough
Regulation of expression of early growth response transcription factors in rat primary cortical neurons by extracellular ATP.
Whooping Cough
Regulation of gadd153 mRNA expression by hypoxia in pulmonary artery smooth muscle cells.
Whooping Cough
Regulation of glucose transport by insulin, bombesin, and bradykinin in Swiss 3T3 fibroblasts: involvement of protein kinase C-dependent and -independent mechanisms.
Whooping Cough
Regulation of lysophosphatidic acid-stimulated tyrosine phosphorylation of mitogen-activated protein kinase by protein kinase C- and pertussis toxin-dependent pathways in the endothelial cell line EAhy 926.
Whooping Cough
Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells.
Whooping Cough
Regulation of Ras.GTP loading and Ras-Raf association in neonatal rat ventricular myocytes by G protein-coupled receptor agonists and phorbol ester. Activation of the extracellular signal-regulated kinase cascade by phorbol ester is mediated by Ras.
Whooping Cough
Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms.
Whooping Cough
Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.
Whooping Cough
Retinoic acid-induced gene expression of tissue transglutaminase via protein kinase C-dependent pathway in mouse peritoneal macrophages.
Whooping Cough
Role of adenosine on glucagon-induced cAMP in a human cortical collecting duct cell line.
Whooping Cough
Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (betaTC-3) cells to glucose-dependent insulinotropic polypeptide.
Whooping Cough
Role of intracellular signalling pathways in hydrogen peroxide-induced injury to rat glomerular mesangial cells.
Whooping Cough
Role of protein kinase Calpha in signaling from the histamine H(1) receptor to the nucleus.
Whooping Cough
Secretoneurin-induced in vitro chemotaxis of human monocytes is inhibited by pertussis toxin and an inhibitor of protein kinase C.
Whooping Cough
Signal transduction in monocytes and granulocytes measured by multiparameter flow cytometry.
Whooping Cough
Signal transduction pathways activated by engaging immunoglobulin Fc receptors on chicken heterophils.
Whooping Cough
Signaling cross-talk between cannabinoid and muscarinic systems actives Rho-kinase and increases the contractile responses of the bovine ciliary muscle.
Whooping Cough
Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression.
Whooping Cough
Signaling pathways for tissue factor expression in lipopolysaccharide-stimulated bovine alveolar macrophages.
Whooping Cough
Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons.
Whooping Cough
Signalling pathways regulating human neutrophil migration induced by secretory phospholipases A2.
Whooping Cough
Similar involvement of VIP receptor type I and type II in lymphocyte chemotaxis.
Whooping Cough
Single transmembrane domain insulin-like growth factor-II/mannose-6-phosphate receptor regulates central cholinergic function by activating a G-protein-sensitive, protein kinase C-dependent pathway.
Whooping Cough
Soluble vascular cell adhesion molecule 1 mediation of monocyte chemotaxis in rheumatoid arthritis.
Whooping Cough
SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathway.
Whooping Cough
Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells.
Whooping Cough
Sphingosine 1-phosphate mobilizes sequestered calcium, activates calcium entry, and stimulates deoxyribonucleic acid synthesis in thyroid FRTL-5 cells.
Whooping Cough
Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor.
Whooping Cough
Sphingosylphosphorylcholine activation of mitogen-activated protein kinase in Swiss 3T3 cells requires protein kinase C and a pertussis toxin-sensitive G protein.
Whooping Cough
Staphylococcus albus-induced protein kinase C translocation in human neutrophils: the effect of opsonization, cytochalasin B, pertussis toxin, intra- and extracellular calcium, and R59022.
Whooping Cough
Stimulation by extracellular ATP and UTP of the stress-activated protein kinase cascade in rat renal mesangial cells.
Whooping Cough
Stimulation of a histone H4 protein kinase in Triton X-100 lysates of rabbit peritoneal neutrophils pretreated with chemotactic factors: lack of requirements of calcium mobilization and protein kinase C activation.
Whooping Cough
Stimulation of extracellular signal-regulated kinases and proliferation in the human gastric cancer cells KATO-III by obestatin.
Whooping Cough
Stimulation of reactive oxidant production in neutrophils by soluble and insoluble immune complexes occurs via different receptors/signal transduction systems.
Whooping Cough
Stimulation of T cells through the CD3/T-cell receptor complex: role of cytoplasmic calcium, protein kinase C translocation, and phosphorylation of pp60c-src in the activation pathway.
Whooping Cough
Stimulation of the intracellular killing of Staphylococcus aureus by human monocytes mediated by Fc gamma receptors I and II.
Whooping Cough
Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells.
Whooping Cough
Studies on molecular regulation of phagocytosis in neutrophils. Con A-mediated ingestion and associated respiratory burst independent of phosphoinositide turnover, rise in [Ca2+]i, and arachidonic acid release.
Whooping Cough
Studies on the mechanisms of signalling and inhibition by pertussis toxin of fibroblast growth factor-stimulated mitogenesis in Balb/c 3T3 cells.
Whooping Cough
Study of the functional organization of a novel adenylate cyclase signaling mechanism of insulin action.
Whooping Cough
Subtype specific roles of beta-adrenergic receptors in apoptosis of adult rat ventricular myocytes.
Whooping Cough
The calcitonin receptor stimulates Shc tyrosine phosphorylation and Erk1/2 activation. Involvement of Gi, protein kinase C, and calcium.
Whooping Cough
The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C.
Whooping Cough
The human V3 pituitary vasopressin receptor: ligand binding profile and density-dependent signaling pathways.
Whooping Cough
The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP: evidence for a strong reduction of Ca2+ entry in single nerve terminals.
Whooping Cough
The opposing effects of calmodulin, adenosine 5'-triphosphate, and pertussis toxin on phorbol ester induced inhibition of atrial natriuretic factor stimulated guanylate cyclase in SK-NEP-1 cells.
Whooping Cough
The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues.
Whooping Cough
The prostaglandin E series modulates high-voltage-activated calcium channels probably through the EP3 receptor in rat paratracheal ganglia.
Whooping Cough
The role of the cytosolic free Ca2+ transient for fMet-Leu-Phe induced actin polymerization in human neutrophils.
Whooping Cough
The thromboxane A2 receptor activates mitogen-activated protein kinase via protein kinase C-dependent Gi coupling and Src-dependent phosphorylation of the epidermal growth factor receptor.
Whooping Cough
The tumor necrosis factor receptor and human neutrophil function. Deactivation and cross-deactivation of tumor necrosis factor-induced neutrophil responses by receptor down-regulation.
Whooping Cough
The upstream regulation of p38 mitogen-activated protein kinase phosphorylation by arachidonic acid in rat neutrophils.
Whooping Cough
Thrombin activation of the Na+/H+ exchanger in vascular smooth muscle cells. Evidence for a kinase C-independent pathway which is Ca2+-dependent and pertussis toxin-sensitive.
Whooping Cough
Thrombin induces c-fos expression in cultured human endothelial cells by a Ca2(+)-dependent mechanism.
Whooping Cough
Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells.
Whooping Cough
Transcellular signaling and pharmacological modulation of thrombin-induced production of plasminogen activator inhibitor-1 in vascular smooth muscle cells.
Whooping Cough
Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells.
Whooping Cough
Transcriptional regulation of Na/K-ATPase by corticosteroids, glycyrrhetinic acid and second messenger pathways in rat kidney epithelial cells.
Whooping Cough
Transforming growth factor-beta inhibits phosphate transport in renal epithelial cells.
Whooping Cough
Transforming growth factor-beta-mediated proliferation of renal tubular epithelial cells involves pertussis toxin-sensitive G protein-and protein kinase C-dependent pathways.
Whooping Cough
Transforming growth factor-beta1 regulation of resting zone chondrocytes is mediated by two separate but interacting pathways.
Whooping Cough
Tricyclic antidepressants inhibit Ca(2+)-activated K(+)-efflux in cultured spinal cord neurons.
Whooping Cough
Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells.
Whooping Cough
Tumor necrosis factor-alpha/cachectin activates the O2(-)-generating system of human neutrophils independently of the hydrolysis of phosphoinositides and the release of arachidonic acid.
Whooping Cough
Two distinct pathways in the down-regulation of type-1 angiotension II receptor gene in rat glomerular mesangial cells.
Whooping Cough
Tyrosine phosphorylation in activated human neutrophils. Comparison of the effects of different classes of agonists and identification of the signaling pathways involved.
Whooping Cough
Vasopressin rapidly stimulates protein kinase C in digitonin-permeabilized Swiss 3T3 cells: involvement of a pertussis toxin-insensitive guanine nucleotide binding protein.
Whooping Cough
Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA.
Whooping Cough
[Activation mechanisms by thrombin and vasopressin of fibroblasts in spontaneously hypertensive rats]
Whooping Cough
[Effects of praeruptorin C on cell hypertrophy, intracellular [Ca2+]i, nitric oxide and signal transduction in isolated hypertrophied rat smooth muscle cells induced by angiotensin II]
Whooping Cough
[Intracellular signal transmission of low density lipoprotein receptors in human monocytes]
Whooping Cough
[Kainate receptors. Their function in the regulation of GABAergic synaptic transmission in the hippocampus]
Whooping Cough
[Mitogenic signaling pathways of growth factors can be distinguished by the involvement of pertussis toxin-sensitive GTP-binding protein and of protein kinase C]
Whooping Cough
[The involvement of muscarinic M1 receptor in the regulation of action potentials in mouse isolated right atria]
Wiskott-Aldrich Syndrome
Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension.
Zellweger Syndrome
Phospholipase D activity is altered in X-linked adrenoleukodystrophy heterozygous carriers, but not in hemizygous patients.
Zellweger Syndrome
Protein kinase C activity, phosphate uptake and endogenous substrate phosphorylation are altered in Zellweger syndrome.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0174
FKKQGSFAKKK
isozyme PKCalpha, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C
additional information
additional information
kinetic parameters of wild type and mutant full-length and truncated GST-CK1delta fusion proteins
-
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
kinetic parameters of wild type and mutant full-length and truncated GST-CK1delta fusion proteins
-
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
brenda
shows higher levels of PKCalpha than normal breast tissue
brenda
shows higher levels of PKCalpha than normal liver tissue
brenda
-
brenda
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
site-specific phosphorylation of casein kinase 1delta by the enzyme contributes to fine-tuning of casein kinase 1delta activity
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). KPCA_HUMAN
672
0
76750
Swiss-Prot
other Location (Reliability: 2)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
casein kinase 1 delta is modulated by protein kinase C alpha (PKCalpha) by site-specific phosphorylation within the kinase domain of CK1delta
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in HEK-293 cells and human-derived rhabdhomyosarcoma cells
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
McSwine-Kennick, R.L.; McKeegan, E.M.; Johnson, M.D.; Morin, M.J.
Phorbol diester-induced alterations in the expression of protein kinase C isozymes and their mRNAs. Analysis in wild-type and phorbol diester-resistant HL-60 cell clones
J. Biol. Chem.
266
15135-15143
1991
Homo sapiens (P17252)
brenda
Finkenzeller, G.; Marme, D.; Hug, H.
Sequence of human protein kinase C alpha
Nucleic Acids Res.
18
2183
1990
Homo sapiens (P17252), Homo sapiens
brenda
Alfa Cisse, M.; Louis, K.; Braun, U.; Mari, B.; Leitges, M.; Slack, B.E.; Fisher, A.; Auberger, P.; Checler, F.; Vincent, B.
Isoform-specific contribution of protein kinase C to prion processing
Mol. Cell. Neurosci.
39
400-410
2008
Homo sapiens (P17252), Homo sapiens (Q02156), Homo sapiens (Q05513), Homo sapiens (Q05655)
brenda
Kang, J.H.; Asai, D.; Yamada, S.; Toita, R.; Oishi, J.; Mori, T.; Niidome, T.; Katayama, Y.
A short peptide is a protein kinase C (PKC) alpha-specific substrate
Proteomics
8
2006-2011
2008
Homo sapiens (P05129), Homo sapiens (P05771), Homo sapiens (P17252), Homo sapiens (P24723), Homo sapiens (P41743), Homo sapiens (Q02156), Homo sapiens (Q04759), Homo sapiens (Q05513), Homo sapiens (Q05655), Homo sapiens
brenda
Ninsontia, C.; Phiboonchaiyanan, P.P.; Kiratipaiboon, C.; Chanvorachote, P.
Zinc suppresses stem cell properties of lung cancer cells through protein kinase C-mediated beta-catenin degradation
Am. J. Physiol. Cell Physiol.
312
C487-C499
2017
Homo sapiens (P17252)
brenda
Meng, Z.; B hm, T.; Xu, P.; Henne-Bruns, D.; Peifer, C.; Witt, L.; Knippschild, U.; Bischof, J.
Kinase activity of casein kinase 1 delta (CK1delta)is modulated by protein kinase C alpha (PKCalpha) by site-specific phosphorylation within the kinase domain of CK1delta
Biochim. Biophys. Acta
1867
710-721
2019
Homo sapiens (P17252)
brenda
Meng, Z.; Bhm, T.; Xu, P.; Henne-Bruns, D.; Peifer, C.; Witt, L.; Knippschild, U.; Bischof, J.
Kinase activity of casein kinase 1 delta (CK1delta) is modulated by protein kinase Calpha (PKCalpha) by site-specific phosphorylation within the kinase domain of CK1delta
Biochim. Biophys. Acta Proteins Proteom.
1867
710-721
2019
Homo sapiens (P17252)
brenda
Lee, S.; Devamani, T.; Song, H.D.; Sandhu, M.; Larsen, A.; Sommese, R.; Jain, A.; Vaidehi, N.; Sivaramakrishnan, S.
Distinct structural mechanisms determine substrate affinity and kinase activity of protein kinase Calpha
J. Biol. Chem.
292
16300-16309
2017
Homo sapiens (P17252)
brenda
EXTERNAL LINKS (specific for EC-Number 2.7.11.13)
Transporter Classification Database (TCDB): 8.A.104.1.4
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
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