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Literature summary for 2.7.11.13 extracted from

  • Meng, Z.; B hm, T.; Xu, P.; Henne-Bruns, D.; Peifer, C.; Witt, L.; Knippschild, U.; Bischof, J.
    Kinase activity of casein kinase 1 delta (CK1delta)is modulated by protein kinase C alpha (PKCalpha) by site-specific phosphorylation within the kinase domain of CK1delta (2019), Biochim. Biophys. Acta, 1867, 710-721 .
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
Goe-6983
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00009626
-
 ATP at pH 7.5 and 30°C Homo sapiens
0.01561
-
 casein kinase 1delta at pH 7.5 and 30°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 10 mM used in assay conditions Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P17252
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + casein kinase 1delta the enzyme phosphorylates the kinase domain of casein kinase 1delta at Ser53, Thr176, and Ser181 Homo sapiens ADP + phosphorylated casein kinase 1delta
-
 ?

Synonyms

Synonyms Comment Organism
PKCalpha
-
 Homo sapiens
protein kinase C alpha
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.136
-
 casein kinase 1delta at pH 7.5 and 30°C Homo sapiens

General Information

General Information Comment Organism
metabolism site-specific phosphorylation of casein kinase 1delta by the enzyme contributes to fine-tuning of casein kinase 1delta activity Homo sapiens