Reference on EC 2.7.1.137 - phosphatidylinositol 3-kinase and Organism(s) Mus musculus and UniProt Accession O70167
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Aksoy, I.A.; Ramsey, M.J.; Fruman, D.A.; Aksoy, S.; Cantley, L.C.; Tucker, J.D.; Roberts, T.M.
Mouse Phosphoinositide 3-Kinase p110a Gene: Cloning, Structural Organization, and Localization to Chromosome 3 Band B
Biochem. Biophys. Res. Commun.
262
438-442
1999
Mus musculus
Bartlett, S.E.; Reynolds, A.J.; Tan, T.; Heydon, K.; Hendry, I.A.
Differential mRNA expression and subcellular locations of PI3-kinase isoforms in sympathetic and sensory neurons
J. Neurosci. Res.
56
44-53
1999
Mus musculus
Berggren, M.I.; Gallegos, A.; Dressler, L.A.; Modest, E.J.; Powis, G.
Inhibition of the signalling enzyme phosphatidylinositol-3-kinase by antitumor ether lipid analogs
Cancer Res.
53
4297-4302
1993
Bos taurus, Mus musculus
Cataldi, A.; Di Pietro, R.; Centurione, L.; Grilli, A.; Cutroneo, G.; Miscia, S.
Phosphatidylinositol-3-kinase activation and atypical protein kinase C z phosphorylation characterize the DMSO signaling in erythroleukemia cells
Cell. Signal.
12
667-672
2000
Mus musculus
Chantry, D.; Vojtek, A.; Kashishian, A.; Holtzman, D.A.; Wood, C.; Gray, P.W.; Cooper, J.A.; Hoekstra, M.F.
p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
J. Biol. Chem.
272
19236-19241
1997
Homo sapiens, Homo sapiens (O00329), Mus musculus, Mus musculus (O35940)
Domin, J.; Dhand, R.; Waterfield, M.D.
Binding to the platelet-derived growth factor receptor transiently activates the p85a-p110a phosphoinositide 3-kinase complex in vivo
J. Biol. Chem.
271
21614-21621
1996
Mus musculus
Karnitz, L.M.; Sutor, S.L.; Abraham, R.T.
The Src-Family Kinase, Fyn, Regulates the Activation of Phosphatidylinositol 3-Kinase in an Interleukin 2-responsive T cell Line
J. Exp. Med.
179
1799-1808
1994
Mus musculus
Kerouz, N.J.; Horsch, D.; Pons, S.; Kahn, C.R.
Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
J. Clin. Invest.
100
3164-3172
1997
Mus musculus
Khan, F.A.; Goforth, P.B.; Zhang, M.; Satin, L.S.
Insulin activates ATP-sensitive K+ channels in pancreatic b-cells through a phosphatidylinositol 3-kinase-dependent pathway
Diabetes
50
2192-2198
2001
Mus musculus
Le Marchand-Brustel, Y.; Heydrick, S.J.; Jullien, D.; Gautier, N.; Van Obberghen, E.
Effect of insulin and insulin-like growth factor-I on glucose transport and its transporters in soleus muscle of lean and obese mice
Metab. Clin. Exp.
44
18-23
1995
Mus musculus
Lu, P.J.; Hsu, A.L.; Wang, D.S.; Yan, H.Y.; Yin, H.L.; Chen, C.S.
Phosphoinositide 3-kinase in rat liver nuclei
Biochemistry
37
5738-5745
1998
Mus musculus
Mauvais-Jarvis, F.; Ueki, K.; Fruman, D.A.; Hirshman, M.F.; Sakamoto, K.; Goodyear, L.J.; Iannacone, M.; Accili, D.; Cantley, L.C.; Kahn, C.R.
Reduced expression of the murine p85a subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
J. Clin. Invest.
109
141-149
2002
Mus musculus
Minshall, C.; Arkins, S.; Freund, G.G.; Kelley, K.W.
Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor
J. Immunol.
156
939-947
1996
Mus musculus
Miyakawa, Y.; Rojnuckarin, P.; Habib, T.; Kaushansky, K.
Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes
J. Biol. Chem.
276
2494-2502
2001
Mus musculus
Virbasius, J.V.; Guilherme, A.; Czech, M.P.
Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain
J. Biol. Chem.
271
13304-13307
1996
Mus musculus
Wang, D.; Sul, H.S.
Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt
J. Biol. Chem.
273
25420-25426
1998
Mus musculus
Wang, Q.; Bilan, P.J.; Tsakiridis, T.; Hinek, A.; Klip, A.
Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes
Biochem. J.
331
917-928
1998
Mus musculus
-
Yang, J.; Clarke, J.F.; Ester, C.J.; Young, P.W.; Kasuga, M.; Holman, G.D.
Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells
Biochem. J.
313
125-131
1996
Mus musculus
-
Klippel, A.; Escobedo, J.A.; Hirano, M.; Williams, L.T.
The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity
Mol. Cell. Biol.
14
2675-2685
1994
Mus musculus (P42337), Mus musculus
Misawa, H.; Ohtsubo, M.; Copeland, N.G.; Gilbert, D.J.; Jenkins, N.A.; Yoshimura, A.
Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain
Biochem. Biophys. Res. Commun.
244
531-539
1998
Mus musculus (O70167), Mus musculus
Pietrucha, R.; Rubio, I.; Wymann, M.P.; Wetzker, R.
Phosphoinositide 3-kinase gamma mediates Jun kinase activation via its lipid-kinase activity
Adv. Enzyme Regul.
44
299-308
2004
Mus musculus
Gray, A.; Olsson, H.; Batty, I.H.; Priganica, L.; Peter Downes, C.
Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts
Anal. Biochem.
313
234-245
2003
Mus musculus
El-Kholy, W.; Macdonald, P.E.; Lin, J.H.; Wang, J.; Fox, J.M.; Light, P.E.; Wang, Q.; Tsushima, R.G.; Wheeler, M.B.
The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism
FASEB J.
17
720-722
2003
Mus musculus, Rattus norvegicus
Liu, L.; Song, X.; He, D.; Komma, C.; Kita, A.; Virbasius, J.V.; Huang, G.; Bellamy, H.D.; Miki, K.; Czech, M.P.; Zhou, G.W.
Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2alpha
J. Biol. Chem.
281
4254-4260
2006
Mus musculus
Voigt, P.; Dorner, M.B.; Schaefer, M.
Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B
J. Biol. Chem.
281
9977-9986
2006
Mus musculus (Q3U6Q4)
O'Connor, J.C.; Sherry, C.L.; Guest, C.B.; Freund, G.G.
Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3
J. Immunol.
178
6886-6893
2007
Mus musculus
Tang, C.H.; Lu, D.Y.; Yang, R.S.; Tsai, H.Y.; Kao, M.C.; Fu, W.M.; Chen, Y.F.
Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia
J. Immunol.
179
1292-1302
2007
Mus musculus
Furuya, F.; Lu, C.; Willingham, M.C.; Cheng, S.Y.
Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer
Carcinogenesis
28
2451-2458
2007
Mus musculus
Kim, J.H.; Na, H.J.; Kim, C.K.; Kim, J.Y.; Ha, K.S.; Lee, H.; Chung, H.T.; Kwon, H.J.; Kwon, Y.G.; Kim, Y.M.
The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: Role of H2O2 in NF-kappaB activation
Free Radic. Biol. Med.
45
885-896
2008
Mus musculus
Lee, Y.; Huang, H.; Kim, H.J.; Park, C.K.; Kim, H.H.
The phosphatidylinositol 3-kinase-mediated production of interferon-beta is critical for the lipopolysaccharide inhibition of osteoclastogenesis
Life Sci.
83
369-376
2008
Mus musculus
Lee, S.A.; Park, S.H.; Kim, B.C.
Raloxifene, a selective estrogen receptor modulator, inhibits lipopolysaccharide-induced nitric oxide production by inhibiting the phosphatidylinositol 3-kinase/Akt/nuclear factor-kappa B pathway in RAW264.7 macrophage cells
Mol. Cells
26
48-52
2008
Mus musculus
Yu, W.Z.; Zou, H.; Li, X.X.; Yan, Z.; Dong, J.Q.
Effects of the phosphatidylinositol 3-kinase inhibitor in a mouse model of retinal neovascularization
Ophthalmic Res.
40
19-25
2008
Mus musculus
Ban, K.; Cooper, A.J.; Samuel, S.; Bhatti, A.; Patel, M.; Izumo, S.; Penninger, J.M.; Backx, P.H.; Oudit, G.Y.; Tsushima, R.G.
Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning
Circ. Res.
103
643-653
2008
Mus musculus, Mus musculus C57BL/6
Wu, J.; Wrathall, J.R.; Schachner, M.
Phosphatidylinositol 3-kinase/protein kinase Cdelta activation induces close homolog of adhesion molecule L1 (CHL1) expression in cultured astrocytes
Glia
58
315-328
2010
Mus musculus, Mus musculus C57BL/6
Son, G.; Hines, I.N.; Lindquist, J.; Schrum, L.W.; Rippe, R.A.
Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis
Hepatology
50
1512-1523
2009
Mus musculus
Ayral-Kaloustian, S.; Gu, J.; Lucas, J.; Cinque, M.; Gaydos, C.; Zask, A.; Chaudhary, I.; Wang, J.; Di, L.; Young, M.; Ruppen, M.; Mansour, T.S.; Gibbons, J.J.; Yu, K.
Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates
J. Med. Chem.
53
452-459
2009
Homo sapiens, Mus musculus
Pereira, R.I.; Leitner, J.W.; Erickson, C.; Draznin, B.
Pioglitazone acutely stimulates adiponectin secretion from mouse and human adipocytes via activation of the phosphatidylinositol 3-kinase
Life Sci.
83
638-643
2008
Homo sapiens, Mus musculus
Zhou, L.; Takayama, Y.; Boucher, P.; Tallquist, M.; Herz, J.
LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation
PLoS ONE
4
e6922
2009
Mus musculus
Wu, Y.; Tan, H.; Shui, G.; Bauvy, C.; Huang, Q.; Wenk, M.; Ong, C.; Codogno, P.; Shen, H.
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase
J. Biol. Chem.
285
10850-10861
2010
Homo sapiens, Mus musculus
Inaguma, Y.; Ito, H.; Iwamoto, I.; Matsumoto, A.; Yamagata, T.; Tabata, H.; Nagata, K.
Morphological characterization of class III phosphoinositide 3-kinase during mouse brain development
Med. Mol. Morphol.
49
28-33
2016
Mus musculus (Q6PF93), Mus musculus
