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Literature summary for 2.7.1.137 extracted from

  • Zhou, L.; Takayama, Y.; Boucher, P.; Tallquist, M.; Herz, J.
    LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation (2009), PLoS ONE, 4, e6922.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.137

Activating Compound

Activating Compound Comment Organism Structure
activated PDGFRbeta PI3K binding to the cytoplasmic domain of activated PDGFRbeta receptors requires phosphorylation at residues 739 and 750 and this interaction in turn activates the kinase Mus musculus
low density lipoprotein receptor-related protein 1 LRP1, positively regulates PI3K activation. LRP1-deficient smooth muscle cells show disorganized actin in the form of membrane ruffling and enhanced cell migration, and show abnormal activation of TGFbeta signaling Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
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 Mus musculus 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus activated PDGFRbeta interacts with PI3 kinase, which binds to the phosphorylated Tyr739 and Tyr750 residues, in the signaling cascade in vascular smooth muscle cells. disruption of PDGFRbeta-PI3K signaling in mice reduces atherosclerosis. PDGF-BB-induced chemotaxis is inhibited by blocking PI3K activation through PDGFRbeta ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
smooth muscle cell vascular Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information activated PDGFRbeta interacts with PI3 kinase, which binds to the phosphorylated Tyr739 and Tyr750 residues, in the signaling cascade in vascular smooth muscle cells. disruption of PDGFRbeta-PI3K signaling in mice reduces atherosclerosis. PDGF-BB-induced chemotaxis is inhibited by blocking PI3K activation through PDGFRbeta Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
PI3 kinase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction disruption of PDGFRbeta-PI3K signaling in mice reduces atherosclerosis. Disorganization of the actin cytoskeleton in LRP1-deficient smooth muscle cells is prevented by blocking PI3K activation by PDGFRbeta Mus musculus
physiological function PI3K is involved in regulation of actin polymerization and cell movement Mus musculus