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Literature summary for 2.7.1.137 extracted from

  • Pietrucha, R.; Rubio, I.; Wymann, M.P.; Wetzker, R.
    Phosphoinositide 3-kinase gamma mediates Jun kinase activation via its lipid-kinase activity (2004), Adv. Enzyme Regul., 44, 299-308.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
G-protein betagamma subunits betagamma subunits of heterotrimeric G-protein Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant HA-tagged PI3K isozyme gamma and of subunit p110 in COS-7 cells, stimulation of the protein kinases Erk, JNK, and PKB Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information no JNK stimulation in enzyme-deficient mutant cells or by enzyme p110delta mutants Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane the enzyme binds to the plasma membrane to get access to its lipid substrate phosphatidylinositol-4,5-bisphosphate, membrane binding via the C-terminal CAAX domain Mus musculus 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + phosphatidylinositol-4,5-bisphosphate Mus musculus
-
ADP + phosphatidylinositol-3,4,5-trisphosphate
-
?
ATP + phosphatidylinositol-4-phosphate Mus musculus
-
ADP + phosphatidylinositol-3,4-bisphosphate
-
?
additional information Mus musculus the isozyme gamma stimulates the protein kinases Erk, JNK, and PKB and thus plays a role in cellular signaling, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
isozyme gamma
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme performs autophosphorylation at Ser1039 of the catalytic p110delta subunit Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + phosphatidylinositol-4,5-bisphosphate
-
Mus musculus ADP + phosphatidylinositol-3,4,5-trisphosphate
-
?
ATP + phosphatidylinositol-4-phosphate
-
Mus musculus ADP + phosphatidylinositol-3,4-bisphosphate
-
?
additional information the isozyme gamma stimulates the protein kinases Erk, JNK, and PKB and thus plays a role in cellular signaling, overview Mus musculus ?
-
?
additional information the enzyme shows both lipid and protein kinase activity Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
phosphoinositide 3-kinase gamma
-
Mus musculus
PI3K
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
kinase assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
kinase assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus