show all | hide all No of entries

Information on EC - 2-amino-4-deoxychorismate synthase

for references in articles please use BRENDA:EC2.6.1.86
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
       2-amino-4-deoxychorismate synthase
IUBMB Comments
Requires Mg2+. The reaction occurs in the reverse direction to that shown above. In contrast to most anthranilate-synthase I (ASI) homologues, this enzyme is not inhibited by tryptophan. In Streptomyces globisporus, the sequential action of this enzyme and EC, 2-amino-4-deoxychorismate dehydrogenase, leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2]. In certain Pseudomonads the enzyme participates in the biosynthesis of phenazine, a precursor for several compounds with antibiotic activity [3,4].
Specify your search results
Select one or more organisms in this record: ?
Word Map
The enzyme appears in viruses and cellular organisms
2-amino-2-deoxyisochorismate (ADIC) synthase, 2-amino-2-deoxyisochorismate synthase, 2-amino-2desoxyisochorismate synthase, ADCS, ADIC synthase, aminodeoxyisochorismate synthase, PabA, PhzE, SgcD, more
(2S)-2-amino-4-deoxychorismate + L-glutamate = chorismate + L-glutamine
show the reaction diagram
Select items on the left to see more content.