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Literature summary for 2.6.1.86 extracted from
- Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism (2008), Proc. Natl. Acad. Sci. USA, 105, 494-499.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| the gene for SgcD is cloned into pET-30 Xa/LIC and expressed in Escherichia coli | Streptomyces globisporus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | SgcD activity is depended on the inclusion of Mg2+ | Streptomyces globisporus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 58500 | - |
x * 58500, SDS-PAGE | Streptomyces globisporus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chorismate + L-glutamine | Streptomyces globisporus | the net conversion of chorismate to 3-enolpyruvoylanthranilate by the tandem action of SgcD and SgcG establishes a new branching point in chorismate metabolism leading to synthesis of C-1027, an enediyne antitumor antibiotic | (2S)-2-amino-4-deoxychorismate + L-glutamate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces globisporus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Streptomyces globisporus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chorismate + L-glutamine | - |
Streptomyces globisporus | (2S)-2-amino-4-deoxychorismate + L-glutamate | - |
? | |
| chorismate + L-glutamine | the net conversion of chorismate to 3-enolpyruvoylanthranilate by the tandem action of SgcD and SgcG establishes a new branching point in chorismate metabolism leading to synthesis of C-1027, an enediyne antitumor antibiotic | Streptomyces globisporus | (2S)-2-amino-4-deoxychorismate + L-glutamate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 58500, SDS-PAGE | Streptomyces globisporus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 2-amino-2-deoxyisochorismate (ADIC) synthase | - |
Streptomyces globisporus |
| 2-amino-2-deoxyisochorismate synthase | - |
Streptomyces globisporus |
| ADIC synthase | - |
Streptomyces globisporus |
| SgcD | - |
Streptomyces globisporus |
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