Any feedback?
Information on EC 2.6.1.21 - D-amino-acid transaminase
for references in articles please use BRENDA:EC2.6.1.21Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
2.6.1.21 D-amino-acid transaminaseIUBMB Comments
A pyridoxal-phosphate protein. The enzyme from thermophilic Bacillus species acts on many D-amino acids with D-alanine and D-2-aminobutyrate as the best amino donors. It can similarly use any of several 2-oxo acids as amino acceptor, with 2-oxoglutarate and 2-oxobutyrate among the best. The enzyme from some other sources has a broader specificity .
Specify your search results
Word Map
- 2.6.1.21
- pyridoxal
- racemase
-
transamination
- d-glutamate
- pyridoxamine
- sphaericus
-
quinonoid
-
aldimine
- 4-amino-4-deoxychorismate
-
yoshimura
-
ketimine
-
pyridoxal-5'-phosphate-dependent
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
d-amino acid aminotransferase, d-amino acid transaminase, d-aat, msmeg_5795, d-alanine aminotransferase, atdat1, aspfum, neofis, gibzea, d-alanine transaminase, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
aminotransferase, D-alanine
-
-
-
-
AtDAT1
D-AA transaminase
D-AAT
D-alanine aminotransferase
-
-
-
-
D-alanine transaminase
-
-
-
-
D-alanine:2-oxoglutarate aminotransferase
D-amino acid aminotransferase
D-amino acid transaminase
D-aspartate transaminase
-
-
-
-
D-aspartic aminotransferase
-
-
-
-
DAA aminotransferase
DAA transaminase
DAAT
DAT
DatA
Dret
Dret_1107
FQP89_01185
MSMEG_5795
TRA-01185
D-alanine:2-oxoglutarate aminotransferase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
D-alanine + 2-oxoglutarate = pyruvate + D-glutamate
Bradyrhizobium japonicum
-
-
-
D-alanine + 2-oxoglutarate = pyruvate + D-glutamate
Bacillus sp. (in: Bacteria)
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
amino group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
BRENDA
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
D-alanine:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. The enzyme from thermophilic Bacillus species acts on many D-amino acids with D-alanine and D-2-aminobutyrate as the best amino donors. It can similarly use any of several 2-oxo acids as amino acceptor, with 2-oxoglutarate and 2-oxobutyrate among the best. The enzyme from some other sources has a broader specificity [6].
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
37277-85-3
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine
5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate
4-(4-methoxyphenyl)butan-2-one + D-alanine
(2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate
beta-chloro-D-alanine
pyruvate + ammonia + Cl-
-
loss in enzyme activity during beta-elimination
-
?
D-arginine + 2-oxoglutarate
? + D-glutamate
-
6% of the activity with D-alanine
-
?
D-ethionine + 2-oxoglutarate
4-ethylsulfanyl-2-oxobutanoate + D-glutamate
-
76% of the activity with D-alanine
-
?
D-glutamine + pyruvate
4-carbamoyl-2-oxobutanoate + D-alanine
-
-
-
?
D-histidine + 2-oxoglutarate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
6% of the activity with D-alanine
-
?
D-histidine + pyruvate
3-(1H-imidazol-4-yl)-2-oxopropanoate + D-alanine
low activity
-
-
?
D-leucine + pyruvate
4-methyl-2-oxopentanoate + D-alanine
low activity
-
-
?
D-methionine + pyruvate
4-methylsulfanyl-2-oxobutanoate + D-alanine
D-methionine is the best and preferred substrate
-
-
r
D-norleucine + pyruvate
2-oxopentanoate + D-alanine
-
-
-
?
D-theanine + 2-oxoglutarate
? + D-glutamate
-
40% of the activity with D-alanine
-
?
D-threonine + 2-oxoglutarate
2-oxobutanoate + D-glutamate
-
-
-
r
D-threonine + pyruvate
2-oxobutanoate + D-alanine
very low activity
-
-
?
D-valine + 2-oxoglutarate
2-oxoisovalerate + D-glutamate
-
5% of activity with D-alanine
-
?
1-(4-nitrophenyl)ethanone + D-alanine
(1R)-1-(4-nitrophenyl)ethanamine + pyruvate
-
asymmetric synthesis, conversion: 74%, enantiomeric excess: 99%
-
-
?
1-(4-nitrophenyl)ethanone + D-alanine
(1R)-1-(4-nitrophenyl)ethanamine + pyruvate
-
asymmetric synthesis, conversion: 68%, enantiomeric excess: 99%
-
-
?
1-(4-nitrophenyl)ethanone + D-alanine
(1R)-1-(4-nitrophenyl)ethanamine + pyruvate
-
asymmetric synthesis, conversion: 8%, enantiomeric excess: 99%
-
-
?
1-(4-nitrophenyl)ethanone + D-alanine
(1R)-1-(4-nitrophenyl)ethanamine + pyruvate
-
asymmetric synthesis, conversion: 17%, enantiomeric excess: 99%
-
-
?
1-(4-nitrophenyl)ethanone + D-alanine
(1R)-1-(4-nitrophenyl)ethanamine + pyruvate
-
asymmetric synthesis, conversion: 3%, enantiomeric excess: 99%
-
-
?
1-(4-nitrophenyl)ethanone + D-alanine
(1R)-1-(4-nitrophenyl)ethanamine + pyruvate
-
asymmetric synthesis, conversion: 6%, enantiomeric excess: 99%
-
-
?
1-(4-nitrophenyl)ethanone + D-alanine
(1R)-1-(4-nitrophenyl)ethanamine + pyruvate
-
asymmetric synthesis, conversion: 1%
-
-
?
1-cyclohexylethanone + D-alanine
(1R)-1-cyclohexylethanamine + pyruvate
-
asymmetric synthesis, conversion: 59%, enantiomeric excess: 99%
-
-
?
1-cyclohexylethanone + D-alanine
(1R)-1-cyclohexylethanamine + pyruvate
-
asymmetric synthesis, conversion: 93%, enantiomeric excess: 99%
-
-
?
1-cyclohexylethanone + D-alanine
(1R)-1-cyclohexylethanamine + pyruvate
-
asymmetric synthesis, conversion: 53%, enantiomeric excess: 99%
-
-
?
1-cyclohexylethanone + D-alanine
(1R)-1-cyclohexylethanamine + pyruvate
-
asymmetric synthesis, conversion: 30%, enantiomeric excess: 99%
-
-
?
1-cyclohexylethanone + D-alanine
(1R)-1-cyclohexylethanamine + pyruvate
-
asymmetric synthesis, conversion: 16%, enantiomeric excess: 99%
-
-
?
1-cyclohexylethanone + D-alanine
(1R)-1-cyclohexylethanamine + pyruvate
-
asymmetric synthesis, conversion: 56%, enantiomeric excess: 99%
-
-
?
1-cyclohexylethanone + D-alanine
(1R)-1-cyclohexylethanamine + pyruvate
-
asymmetric synthesis, conversion: 1%
-
-
?
1-phenylethanone + D-alanine
(1R)-1-phenylethanamine + pyruvate
-
asymmetric synthesis, conversion: 87%, enantiomeric excess: 99%
-
-
?
1-phenylethanone + D-alanine
(1R)-1-phenylethanamine + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
1-phenylethanone + D-alanine
(1R)-1-phenylethanamine + pyruvate
-
asymmetric synthesis, conversion: 39%, enantiomeric excess: 99%
-
-
?
1-phenylethanone + D-alanine
(1R)-1-phenylethanamine + pyruvate
-
asymmetric synthesis, conversion: 3%, enantiomeric excess: 99%
-
-
?
1-phenylethanone + D-alanine
(1R)-1-phenylethanamine + pyruvate
-
asymmetric synthesis, conversion: 4%, enantiomeric excess: 99%
-
-
?
1-phenylethanone + D-alanine
(1R)-1-phenylethanamine + pyruvate
-
asymmetric synthesis, conversion: 42%, enantiomeric excess: 99%
-
-
?
1-phenylethanone + D-alanine
(1R)-1-phenylethanamine + pyruvate
-
asymmetric synthesis, conversion: 1%
-
-
?
4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine
5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine
5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate
-
asymmetric synthesis, conversion: 94%, enantiomeric excess: 99%
-
-
?
4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine
5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate
-
asymmetric synthesis, conversion: 98%, enantiomeric excess: 99%
-
-
?
4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine
5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate
-
asymmetric synthesis, conversion: 77%, enantiomeric excess: 99%
-
-
?
4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine
5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate
-
asymmetric synthesis, conversion: 6%, enantiomeric excess: 99%
-
-
?
4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine
5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate
-
asymmetric synthesis, conversion: 85%, enantiomeric excess: 99%
-
-
?
4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine
5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate
-
asymmetric synthesis, conversion: 1%
-
-
?
4-(4-hydroxyphenyl)butan-2-one + D-alanine
4-[(3R)-3-aminobutyl]phenol + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-(4-hydroxyphenyl)butan-2-one + D-alanine
4-[(3R)-3-aminobutyl]phenol + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-(4-hydroxyphenyl)butan-2-one + D-alanine
4-[(3R)-3-aminobutyl]phenol + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-(4-hydroxyphenyl)butan-2-one + D-alanine
4-[(3R)-3-aminobutyl]phenol + pyruvate
-
asymmetric synthesis, conversion: 83%, enantiomeric excess: 99%
-
-
?
4-(4-hydroxyphenyl)butan-2-one + D-alanine
4-[(3R)-3-aminobutyl]phenol + pyruvate
-
asymmetric synthesis, conversion: 5%, enantiomeric excess: 99%
-
-
?
4-(4-hydroxyphenyl)butan-2-one + D-alanine
4-[(3R)-3-aminobutyl]phenol + pyruvate
-
asymmetric synthesis, conversion: 71%, enantiomeric excess: 99%
-
-
?
4-(4-hydroxyphenyl)butan-2-one + D-alanine
4-[(3R)-3-aminobutyl]phenol + pyruvate
-
asymmetric synthesis, conversion: 1%
-
-
?
4-(4-methoxyphenyl)butan-2-one + D-alanine
(2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate
-
asymmetric synthesis, conversion: 92%, enantiomeric excess: 99%
-
-
?
4-(4-methoxyphenyl)butan-2-one + D-alanine
(2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-(4-methoxyphenyl)butan-2-one + D-alanine
(2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-(4-methoxyphenyl)butan-2-one + D-alanine
(2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate
-
asymmetric synthesis, conversion: 20%, enantiomeric excess: 99%
-
-
?
4-(4-methoxyphenyl)butan-2-one + D-alanine
(2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate
-
asymmetric synthesis, conversion: 7%, enantiomeric excess: 99%
-
-
?
4-(4-methoxyphenyl)butan-2-one + D-alanine
(2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate
-
asymmetric synthesis, conversion: 72%, enantiomeric excess: 99%
-
-
?
4-(4-methoxyphenyl)butan-2-one + D-alanine
(2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate
-
asymmetric synthesis, conversion: 1%
-
-
?
4-methylpentan-2-one + D-alanine
(2R)-2-amino-4-methylpentane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-methylpentan-2-one + D-alanine
(2R)-2-amino-4-methylpentane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-methylpentan-2-one + D-alanine
(2R)-2-amino-4-methylpentane + pyruvate
-
asymmetric synthesis, conversion: 79%, enantiomeric excess: 99%
-
-
?
4-methylpentan-2-one + D-alanine
(2R)-2-amino-4-methylpentane + pyruvate
-
asymmetric synthesis, conversion: 64%, enantiomeric excess: 99%
-
-
?
4-methylpentan-2-one + D-alanine
(2R)-2-amino-4-methylpentane + pyruvate
-
asymmetric synthesis, conversion: 32%, enantiomeric excess: 99%
-
-
?
4-methylpentan-2-one + D-alanine
(2R)-2-amino-4-methylpentane + pyruvate
-
asymmetric synthesis, conversion: 68%, enantiomeric excess: 99%
-
-
?
4-methylpentan-2-one + D-alanine
(2R)-2-amino-4-methylpentane + pyruvate
-
asymmetric synthesis, conversion: 9%, enantiomeric excess: 99%
-
-
?
4-phenylbutan-2-one + D-alanine
(2R)-2-amino-4-phenylbutane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-phenylbutan-2-one + D-alanine
(2R)-2-amino-4-phenylbutane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-phenylbutan-2-one + D-alanine
(2R)-2-amino-4-phenylbutane + pyruvate
-
asymmetric synthesis, conversion: 92%, enantiomeric excess: 99%
-
-
?
4-phenylbutan-2-one + D-alanine
(2R)-2-amino-4-phenylbutane + pyruvate
-
asymmetric synthesis, conversion: 32%, enantiomeric excess: 99%
-
-
?
4-phenylbutan-2-one + D-alanine
(2R)-2-amino-4-phenylbutane + pyruvate
-
asymmetric synthesis, conversion: 9%, enantiomeric excess: 99%
-
-
?
4-phenylbutan-2-one + D-alanine
(2R)-2-amino-4-phenylbutane + pyruvate
-
asymmetric synthesis, conversion: 89%, enantiomeric excess: 99%
-
-
?
4-phenylbutan-2-one + D-alanine
(2R)-2-amino-4-phenylbutane + pyruvate
-
asymmetric synthesis, conversion: 1%
-
-
?
beta-phenylalanine + pyruvate
3-oxo-3-phenylpropionic acid + D-alanine
-
-
-
-
?
beta-phenylalanine + pyruvate
3-oxo-3-phenylpropionic acid + D-alanine
-
-
-
-
?
D-2-aminobutanoate + pyruvate
2-oxobutanoate + D-alanine
-
-
-
?
D-alanine + 2-oxoglutarate
pyruvate + D-glutamate
-
very low activity with: D-histidine, D-phenylalanine, D-arginine and D-lysine, amino acceptors 2-oxoglutarate and pyruvate
-
?
D-alanine + 2-oxoglutarate
pyruvate + D-glutamate
-
-
-
r
D-alanine + 2-oxoglutarate
pyruvate + D-glutamate
-
D-alanine formation is favoured
-
r
D-alanine + 2-oxoglutarate
pyruvate + D-glutamate
-
function of the enzyme is probably the provision of D-amino acids for cell-wall synthesis
-
-
?
D-aminobutanoate + 2-oxoglutarate
oxobutanoate + D-glutamate
-
-
-
?
D-aminobutanoate + 2-oxoglutarate
oxobutanoate + D-glutamate
-
97% of the activity with D-alanine
-
?
D-asparagine + 2-oxoglutarate
2-oxosuccinamate + D-glutamate
-
38% of activity with D-alanine
-
?
D-asparagine + 2-oxoglutarate
2-oxosuccinamate + D-glutamate
-
-
-
?
D-asparagine + 2-oxoglutarate
2-oxosuccinamate + D-glutamate
-
31% of the activity with D-alanine
-
?
D-asparagine + pyruvate
2-oxosuccinamate + D-alanine
low activity
-
-
?
D-asparagine + pyruvate
2-oxosuccinamate + D-alanine
-
-
-
?
D-asparagine + pyruvate
2-oxosuccinamate + D-alanine
-
-
-
?
D-aspartate + 2-oxoglutarate
2-oxosuccinate + D-glutamate
-
-
-
r
D-aspartate + 2-oxoglutarate
2-oxosuccinate + D-glutamate
-
30% of the activity with D-alanine
-
?
D-aspartate + pyruvate
2-oxosuccinate + D-alanine
low activity
-
-
?
D-glutamate + 2-oxobutanoate
2-oxoglutarate + 2-aminobutanoate
-
-
-
?
D-glutamate + 2-oxobutanoate
2-oxoglutarate + 2-aminobutanoate
-
-
-
?
D-glutamate + 2-oxoglutarate
2-oxoglutarate + D-glutamate
-
-
-
?
D-glutamate + 2-oxoglutarate
2-oxoglutarate + D-glutamate
-
-
-
?
D-glutamate + pyruvate
2-oxoglutarate + D-alanine
high activity
-
-
?
D-glutamate + pyruvate
2-oxoglutarate + D-alanine
-
-
-
r
D-glutamine + 2-oxoglutarate
4-carbamoyl-2-oxobutanoate + D-glutamate
-
25% of activity with d-alanine
-
?
D-glutamine + 2-oxoglutarate
4-carbamoyl-2-oxobutanoate + D-glutamate
-
52% of the activity with D-alanine
-
?
D-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + D-glutamate
-
-
-
r
D-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + D-glutamate
Desulfohalobium retbaense ATCC 49708
-
-
-
r
D-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + D-glutamate
-
-
-
r
D-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + D-glutamate
-
-
-
r
D-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + D-glutamate
Desulfohalobium retbaense JCM 16813
-
-
-
r
D-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + D-glutamate
-
-
-
r
D-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + D-glutamate
high activity
-
-
r
D-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + D-glutamate
-
8% of the activity with D-alanine
-
?
D-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + D-glutamate
-
30% of activity with d-alanine
-
?
D-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + D-glutamate
-
weak activity
-
?
D-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + D-glutamate
-
-
-
r
D-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + D-glutamate
low activity
-
-
r
D-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + D-glutamate
Halomonas titanicae SM1922
-
-
-
r
D-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + D-glutamate
Halomonas titanicae SM1922
low activity
-
-
r
D-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + D-glutamate
-
61% of the activity with D-alanine
-
?
D-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + D-glutamate
-
weak activity
-
?
D-methionine + pyruvate
4-methylsulfanyl-2-oxobutanoate + L-alanine