Reference on EC 2.4.1.102 - beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase and Organism(s) Mus musculus and UniProt Accession Q5JCT0
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Oehrlein, R.; Hindsgaul, O.; Palcic, M.M.
Use of the core-2-N-acetylglucosaminyltransferase in the chemical-enzymic synthesis of a sialyl-LeX-containing hexasaccharide found on O-linked glycoproteins
Carbohydr. Res.
244
149-159
1993
Mus musculus
Kuhns, W.; Rutz, V.; Paulsen, H.; Matta, K.L.; Baker, M.A.; Barner, M.; Granovsky, M.; Brockhausen, I.
Processing O-glycan core 1, Galb1-3GalNAca-R. Specificities of core 2, UDP-GlcNAc: Galbeta1-3GalNAc-R(GlcNAc to GalNAc) beta6-N-acetylglucosaminyltransferase and CMP-sialic acid: Galbeta1-3GalNAc-R alpha3-sialyltransferase
Glycoconjugate J.
10
381-394
1993
Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Zeng, S.; Dinter, A.; Eisenkratzer, D.; Biselli, M.; Wandrey, C.; Berger, E.G.
Pilot scale expression and purification of soluble protein A tagged beta1,6N-acetylglucosaminyltransferase in CHO cells
Biochem. Biophys. Res. Commun.
237
653-658
1997
Mus musculus
Koya, D.; Dennis, J.W.; Warren, C.E.; Takahara, N.; Schoen, F.J.; Nishio, Y.; Nakajima, T.; Lipes, M.A.; King, G.L.
Overexpression of core 2 N-acetylglycosaminyltransferase enhances cytokine actions and induces hypertrophic myocardium in transgenic mice
FASEB J.
13
2329-2337
1999
Mus musculus, Rattus norvegicus
Lim, Y.C.; Xie, H.; Come, C.E.; Alexander, S.I.; Grusby, M.J.; Lichtman, A.H.; Luscinskas, F.W.
IL-12, STAT4-dependent up-regulation of CD4+ T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands
J. Immunol.
167
4476-4484
2001
Mus musculus
Yen, T.Y.; Macher, B.A.; Bryson, S.; Chang, X.; Tvaroska, I.; Tse, R.; Takeshita, S.; Lew, A.M.; Datti, A.
Highly conserved cysteines of mouse core 2 beta1,6-N-acetylglucosaminyltransferase I form a network of disulfide bonds and include a thiol that affects enzyme activity
J. Biol. Chem.
278
45864-45881
2003
Mus musculus
Merzaban, J.S.; Zuccolo, J.; Corbel, S.Y.; Williams, M.J.; Ziltener, H.J.
An alternate core 2 beta1,6-N-acetylglucosaminyltransferase selectively contributes to P-selectin ligand formation in activated CD8 T cells
J. Immunol.
174
4051-4059
2005
Mus musculus
Cabrera, P.V.; Amano, M.; Mitoma, J.; Chan, J.; Said, J.; Fukuda, M.; Baum, L.G.
Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death
Blood
108
2399-2406
2006
Mus musculus
Pak, J.E.; Arnoux, P.; Zhou, S.; Sivarajah, P.; Satkunarajah, M.; Xing, X.; Rini, J.M.
X-ray crystal structure of leukocyte type core 2 beta1,6-N-acetylglucosaminyltransferase. Evidence for a convergence of metal ion-independent glycosyltransferase mechanism
J. Biol. Chem.
281
26693-26701
2006
Mus musculus
Hashimoto, M.; Tan, S.; Mori, N.; Cheng, H.; Cheng, P.W.
Mucin biosynthesis: molecular cloning and expression of mouse mucus-type core 2 beta1,6 N-acetylglucosaminyltransferase
Glycobiology
17
994-1006
2007
Mus musculus (Q5JCT0), Mus musculus
Wang, H.; Tang, R.; Zhang, W.; Amirikian, K.; Geng, Z.; Geng, J.; Hebbel, R.P.; Xia, L.; Marth, J.D.; Fukuda, M.; Katoh, S.; Huo, Y.
Core2 1-6-N-glucosaminyltransferase-I is crucial for the formation of atherosclerotic lesions in apolipoprotein E-deficient mice
Arterioscler. Thromb. Vasc. Biol.
29
180-187
2009
Mus musculus
Wang, J.; Shiratori, I.; Satoh, T.; Lanier, L.L.; Arase, H.
An essential role of sialylated O-linked sugar chains in the recognition of mouse CD99 by paired Ig-like type 2 receptor (PILR)
J. Immunol.
180
1686-1693
2008
Mus musculus (Q09324), Mus musculus
Stone, E.L.; Ismail, M.N.; Lee, S.H.; Luu, Y.; Ramirez, K.; Haslam, S.M.; Ho, S.B.; Dell, A.; Fukuda, M.; Marth, J.D.
Glycosyltransferase function in core 2-type protein O glycosylation
Mol. Cell. Biol.
29
3770-3782
2009
Mus musculus, Mus musculus (Q5JCT0)
Nagaraj, S.; Neumann, J.; Winzen, B.; Frank, S.; Ziske, C.; Sievers, E.; Koch, N.; Schmidt-Wolf, I.G.
Pancreas carcinoma antigen fused to invariant chain elicits T-cell response and tumor growth inhibition
Pancreas
37
321-327
2008
Mus musculus
Schroeter, M.F.; Ratsch, B.A.; Lehmann, J.; Baumgrass, R.; Hamann, A.; Syrbe, U.
Differential regulation and impact of fucosyltransferase VII and core 2 beta1,6-N-acetyl-glycosaminyltransferase for generation of E- and P-selectin ligands in murine CD4+ T cells
Immunology
137
294-304
2012
Mus musculus
Pak, J.E.; Satkunarajah, M.; Seetharaman, J.; Rini, J.M.
Structural and mechanistic characterization of leukocyte-type core 2 ?1,6-N-acetylglucosaminyltransferase: a metal-ion-independent GT-A glycosyltransferase
J. Mol. Biol.
414
798-811
2011
Mus musculus (Q09324)
Rao, C.; Janakiram, N.; Madka, V.; Kumar, G.; Scott, E.; Pathuri, G.; Bryant, T.; Kutche, H.; Zhang, Y.; Biddick, L.; Gali, H.; Zhao, Y.; Lightfoot, S.; Mohammed, A.
Small-molecule inhibition of GCNT3 disrupts mucin biosynthesis and malignant cellular behaviors in pancreatic cancer
Cancer Res.
76
1965-1974
2016
Homo sapiens (O95395), Homo sapiens, Mus musculus (Q5JCT0), Mus musculus, Mus musculus C57BL/6 (Q5JCT0)
