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Literature summary for 2.4.1.102 extracted from

  • Kuhns, W.; Rutz, V.; Paulsen, H.; Matta, K.L.; Baker, M.A.; Barner, M.; Granovsky, M.; Brockhausen, I.
    Processing O-glycan core 1, Galb1-3GalNAca-R. Specificities of core 2, UDP-GlcNAc: Galbeta1-3GalNAc-R(GlcNAc to GalNAc) beta6-N-acetylglucosaminyltransferase and CMP-sialic acid: Galbeta1-3GalNAc-R alpha3-sialyltransferase (1993), Glycoconjugate J., 10, 381-394.
    View publication on PubMed
Search for more literature for 2.4.1.102

Inhibitors

Inhibitors Comment Organism Structure
beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl high concentration Homo sapiens
beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl high concentration Mus musculus
Cu2+
-
 Homo sapiens
Cu2+
-
 Mus musculus
Cu2+
-
 Rattus norvegicus
Cu2+
-
 Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens
additional information
-
 additional information
-
 Sus scrofa
0.6
-
 beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl AML cell line Homo sapiens
0.8
-
 beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl AML cell line Homo sapiens
1.1
-
 beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
 Gallus gallus
1.1
-
 beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
 Sus scrofa
1.2
-
 beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
 Rattus norvegicus
1.4
-
 beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
 Sus scrofa
1.4
-
 beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl colon Homo sapiens
2
-
 beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
 Mus musculus
2
-
 3-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
-
 Mus musculus
2
-
 beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-o-nitrophenyl AML cell line Homo sapiens
3.1
-
 4-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
-
 Mus musculus
3.3
-
 3-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl AML cell line Homo sapiens
4.2
-
 4-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
-
 Rattus norvegicus
4.3
-
 3-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
-
 Rattus norvegicus
4.5
-
 3-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl colon Homo sapiens
5
-
 4-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
-
 Sus scrofa
5.5
-
 3-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
-
 Sus scrofa
6.7
-
 4-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl AML cell line Homo sapiens
10
-
 beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-phenyl AML cell line Homo sapiens
10
-
 4-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl colon Homo sapiens
12
-
 beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl
-
 Mus musculus
21
-
 beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl colon Homo sapiens
29
-
 beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl AML cells Homo sapiens
37
-
 beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl CML cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Gallus gallus
-
-
microsome
-
 Homo sapiens
-
-
microsome
-
 Rattus norvegicus
-
-
microsome
-
 Sus scrofa
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information stimulation by divalent cations Mus musculus
additional information stimulation by divalent cations Homo sapiens
additional information stimulation by divalent cations Rattus norvegicus
additional information stimulation by divalent cations Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus
-
 ?
-
 ?
additional information Rattus norvegicus
-
 ?
-
 ?
additional information Sus scrofa
-
 ?
-
 ?
additional information Homo sapiens enzyme activity is increased in patients with chronic myelogenous leukemia CML or acute myeloid leukemia AML ?
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R Mus musculus involved in biosynthesis of O-glycans core class 2 UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R Homo sapiens involved in biosynthesis of O-glycans core class 2 UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R Rattus norvegicus involved in biosynthesis of O-glycans core class 2 UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R Sus scrofa involved in biosynthesis of O-glycans core class 2 UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
acute myeloid leukemia cell acute myeloid leukemia blast cell line Homo sapiens
-
CML cell chronic myelogenous leukemia granulocyte cell line Homo sapiens
-
colonic mucosa
-
 Rattus norvegicus
-
gastric mucosa
-
 Sus scrofa
-
kidney
-
 Mus musculus
-
oviduct
-
 Gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 overview: enzyme activities with several substrates Gallus gallus
additional information
-
 overview: enzyme activities with several substrates Mus musculus
additional information
-
 overview: enzyme activities with several substrates Homo sapiens
additional information
-
 overview: enzyme activities with several substrates Rattus norvegicus
additional information
-
 overview: enzyme activities with several substrates Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information
-
 Mus musculus ?
-
 ?
additional information
-
 Rattus norvegicus ?
-
 ?
additional information
-
 Sus scrofa ?
-
 ?
additional information enzyme activity is increased in patients with chronic myelogenous leukemia CML or acute myeloid leukemia AML Homo sapiens ?
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
 Gallus gallus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D- galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
 Mus musculus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D- galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
 Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D- galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
 Rattus norvegicus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D- galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
 Sus scrofa UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D- galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-D-glucosamine + 3-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
-
 Mus musculus UDP + 3-deoxy-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-D-glucosamine + 3-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
-
 Homo sapiens UDP + 3-deoxy-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-D-glucosamine + 3-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
-
 Rattus norvegicus UDP + 3-deoxy-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-D-glucosamine + 3-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
-
 Sus scrofa UDP + 3-deoxy-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-D-glucosamine + 4-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
-
 Mus musculus UDP + 4-deoxy-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-D-glucosamine + 4-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
-
 Homo sapiens UDP + 4-deoxy-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-D-glucosamine + 4-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
-
 Rattus norvegicus UDP + 4-deoxy-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-D-glucosamine + 4-deoxy-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
-
 Sus scrofa UDP + 4-deoxy-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl
-
 Rattus norvegicus ?
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl
-
 Sus scrofa ?
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl at high concentration inhibitory Gallus gallus ?
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl at high concentration inhibitory Mus musculus ?
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl at high concentration inhibitory Homo sapiens ?
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl requirement for the 4- and 6-hydroxyls of N-acetyl-galactosamine and the hydroxyl of galactose in the acceptor substrate Gallus gallus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl requirement for the 4- and 6-hydroxyls of N-acetyl-galactosamine and the hydroxyl of galactose in the acceptor substrate Mus musculus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl requirement for the 4- and 6-hydroxyls of N-acetyl-galactosamine and the hydroxyl of galactose in the acceptor substrate Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl requirement for the 4- and 6-hydroxyls of N-acetyl-galactosamine and the hydroxyl of galactose in the acceptor substrate Rattus norvegicus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl requirement for the 4- and 6-hydroxyls of N-acetyl-galactosamine and the hydroxyl of galactose in the acceptor substrate Sus scrofa UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-o-nitrophenyl
-
 Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-o-nitrophenyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-o-nitrophenyl
-
 Rattus norvegicus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-o-nitrophenyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-o-nitrophenyl
-
 Sus scrofa UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-o-nitrophenyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
 Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
 Rattus norvegicus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
 Sus scrofa UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-phenyl
-
 Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-phenyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-phenyl
-
 Rattus norvegicus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-phenyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-phenyl
-
 Sus scrofa UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-phenyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R
-
 Mus musculus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R i.e. core class 2 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R
-
 Rattus norvegicus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R i.e. core class 2 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R
-
 Sus scrofa UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R i.e. core class 2 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R substrate specificity Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R i.e. core class 2 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R involved in biosynthesis of O-glycans core class 2 Mus musculus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R involved in biosynthesis of O-glycans core class 2 Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R involved in biosynthesis of O-glycans core class 2 Rattus norvegicus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R involved in biosynthesis of O-glycans core class 2 Sus scrofa UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?

Synonyms

Synonyms Comment Organism
core 6-beta-GlcNAc-T
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.95
-
 beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl AML cells Homo sapiens
1.5
-
 beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl colon Homo sapiens
2
-
 beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl
-
 Mus musculus
2.5
-
 beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl CML cells Homo sapiens