Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
acetyl-CoA + carnitine
CoA + O-acetylcarnitine
acetyl-CoA + carnitine
O-acetylcarnitine + CoASH
acetyl-CoA + L-(-)carnitine
O-acetylcarnitine + CoASH
acyl-CoA + carnitine
acylcarnitine + CoASH
acylcarnitine + CoASH
acyl-CoA + carnitine
CoA + O-acetylcarnitine
acetyl-CoA + carnitine
-
-
-
r
hexanoyl-CoA + carnitine
hexanoylcarnitine + CoASH
-
-
-
?
O-acetylcarnitine + CoASH
acetyl-CoA + carnitine
O-acetylcarnitine + CoASH
acetyl-CoA + L-(-)carnitine
acetyl-CoA + carnitine
CoA + O-acetylcarnitine
acetyl-CoA + carnitine
O-acetylcarnitine + CoASH
acetyl-CoA + L-(-)carnitine
O-acetylcarnitine + CoASH
acetyl-CoA + L-carnitine
CoA + O-acetylcarnitine
-
-
-
-
?
acyl-CoA + carnitine
acylcarnitine + CoASH
acyl-CoA + L-carnitine
CoA + O-acylcarnitine
acylcarnitine + CoASH
acyl-CoA + carnitine
butyryl-CoA + carnitine
CoA + O-butyrylcarnitine
-
-
-
-
r
decanoyl-CoA + carnitine
decanoylcarnitine + CoASH
-
-
-
-
r
decanoylcarnitine + CoASH
decanoyl-CoA + carnitine
-
-
-
-
r
hexanoyl-CoA + carnitine
hexanoylcarnitine + CoASH
-
-
-
-
r
hexanoylcarnitine + CoASH
hexanoyl-CoA + carnitine
-
-
-
-
r
n-butyryl-CoA + carnitine
n-butyrylcarnitine + CoASH
-
-
-
-
r
n-butyrylcarnitine + CoASH
n-butyryl-CoA + carnitine
-
-
-
-
r
O-acetylcarnitine + CoASH
acetyl-CoA + carnitine
O-acetylcarnitine + CoASH
acetyl-CoA + L-(-)carnitine
octanoyl-CoA + carnitine
octanoylcarnitine + CoASH
-
-
-
-
r
octanoylcarnitine + CoASH
octanoyl-CoA + carnitine
-
-
-
-
r
propionyl-CoA + L-(-)carnitine
propionylcarnitine + CoASH
-
-
-
-
r
propionylcarnitine + CoASH
propionyl-CoA + L-(-)carnitine
-
-
-
-
r
acetyl-CoA + carnitine
CoA + O-acetylcarnitine
-
-
-
?
acetyl-CoA + carnitine
CoA + O-acetylcarnitine
-
-
-
r
acetyl-CoA + carnitine
O-acetylcarnitine + CoASH
-
-
-
r
acetyl-CoA + carnitine
O-acetylcarnitine + CoASH
-
-
-
r
acetyl-CoA + L-(-)carnitine
O-acetylcarnitine + CoASH
-
-
-
r
acetyl-CoA + L-(-)carnitine
O-acetylcarnitine + CoASH
-
-
-
r
acyl-CoA + carnitine
acylcarnitine + CoASH
-
-
-
r
acyl-CoA + carnitine
acylcarnitine + CoASH
-
-
-
r
acylcarnitine + CoASH
acyl-CoA + carnitine
-
-
-
r
acylcarnitine + CoASH
acyl-CoA + carnitine
-
-
-
r
O-acetylcarnitine + CoASH
acetyl-CoA + carnitine
-
-
-
r
O-acetylcarnitine + CoASH
acetyl-CoA + carnitine
-
-
-
r
O-acetylcarnitine + CoASH
acetyl-CoA + L-(-)carnitine
-
-
-
r
O-acetylcarnitine + CoASH
acetyl-CoA + L-(-)carnitine
-
-
-
r
acetyl-CoA + carnitine
CoA + O-acetylcarnitine
-
-
-
-
r
acetyl-CoA + carnitine
CoA + O-acetylcarnitine
-
modulates acetyl-CoA and CoA availability for a wide range of acyl-transfer reactions, involved in fatty acid metabolism
-
-
r
acetyl-CoA + carnitine
O-acetylcarnitine + CoASH
-
-
-
-
r
acetyl-CoA + carnitine
O-acetylcarnitine + CoASH
-
-
-
r
acetyl-CoA + carnitine
O-acetylcarnitine + CoASH
-
-
-
r
acetyl-CoA + L-(-)carnitine
O-acetylcarnitine + CoASH
-
-
-
-
r
acetyl-CoA + L-(-)carnitine
O-acetylcarnitine + CoASH
-
-
-
r
acetyl-CoA + L-(-)carnitine
O-acetylcarnitine + CoASH
-
-
-
r
acyl-CoA + carnitine
acylcarnitine + CoASH
-
-
-
-
r
acyl-CoA + carnitine
acylcarnitine + CoASH
-
-
-
r
acyl-CoA + carnitine
acylcarnitine + CoASH
-
-
-
r
acyl-CoA + L-carnitine
CoA + O-acylcarnitine
-
-
-
-
?
acyl-CoA + L-carnitine
CoA + O-acylcarnitine
-
-
-
-
r
acylcarnitine + CoASH
acyl-CoA + carnitine
-
-
-
-
r
acylcarnitine + CoASH
acyl-CoA + carnitine
-
-
-
r
acylcarnitine + CoASH
acyl-CoA + carnitine
-
-
-
r
O-acetylcarnitine + CoASH
acetyl-CoA + carnitine
-
-
-
-
r
O-acetylcarnitine + CoASH
acetyl-CoA + carnitine
-
-
-
r
O-acetylcarnitine + CoASH
acetyl-CoA + carnitine
-
-
-
r
O-acetylcarnitine + CoASH
acetyl-CoA + L-(-)carnitine
-
-
-
-
r
O-acetylcarnitine + CoASH
acetyl-CoA + L-(-)carnitine
-
-
-
r
O-acetylcarnitine + CoASH
acetyl-CoA + L-(-)carnitine
-
-
-
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.021 - 0.0921
acetyl-CoA
0.0035 - 0.0562
carnitine
0.0224 - 0.112
hexanoyl-CoA
0.121 - 0.519
L-carnitine
0.021
acetyl-CoA
21°C, pH 7.8, wild-type enzyme
0.0324
acetyl-CoA
21°C, pH 7.8, mutant enzyme H343E
0.0596
acetyl-CoA
21°C, pH 7.8, mutant enzyme S554A/M564G
0.0746
acetyl-CoA
21°C, pH 7.8, mutant enzyme M564G
0.0921
acetyl-CoA
21°C, pH 7.8, mutant enzyme S554A
0.0035
carnitine
liver homogenate, pH 8.0, temperature not specified in the publication
0.011
carnitine
mitochondria from liver, pH 8.0, temperature not specified in the publication
0.0537
carnitine
heart homogenate, pH 8.0, temperature not specified in the publication
0.0562
carnitine
mitochondria from heart, pH 8.0, temperature not specified in the publication
0.0328
CoA
mitochondria from heart, pH 8.0, temperature not specified in the publication
0.0664
CoA
heart homogenate, pH 8.0, temperature not specified in the publication
0.0888
CoA
mitochondria from liver, pH 8.0, temperature not specified in the publication
0.1134
CoA
liver homogenate, pH 8.0, temperature not specified in the publication
0.0224
hexanoyl-CoA
21°C, pH 7.8, mutant enzyme M564G
0.0415
hexanoyl-CoA
21°C, pH 7.8, mutant enzyme S554A
0.1034
hexanoyl-CoA
21°C, pH 7.8, wild-type enzyme
0.112
hexanoyl-CoA
21°C, pH 7.8, mutant enzyme S554A/M564G
0.121
L-carnitine
-
cosubstrate butanoyl-CoA
0.344
L-carnitine
-
cosubstrate hexanoyl-CoA
0.395
L-carnitine
-
cosubstrate octanoyl-CoA
0.519
L-carnitine
-
cosubstrate decanoyl-CoA
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Farrell, S.O.; Fiol, C.J.; Reddy, J.K.; Bieber, L.L.
Properties of purified carnitine acyltransferases of mouse liver peroxisomes
J. Biol. Chem.
259
13089-13095
1984
Bos taurus, Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley, Torulopsis bovina
brenda
Bieber, L.L.; Fiol, C.
Purification and assay of carnitine acyltransferases
Methods Enzymol.
123
276-284
1986
Candida tropicalis, Mus musculus
brenda
Lu, F.J.; Huang, T.S.; Chen, Y.S.
Effects of humic acid-metal complexes on hepatic carnitine palmitoyltransferase, carnitine acetyltransferase and catalase activities
Environ. Toxicol. Chem.
13
435-441
1994
Mus musculus, Mus musculus BALB/c
-
brenda
Alhomida, A.S.
Inhibition studies of the carnitine acetyltransferase from skeletal muscle of the camel (Camelus dromedarius) by sulfhydryl reagents and metal ions
Biochem. Mol. Biol. Int.
39
923-931
1996
Camelus dromedarius, Columba sp., Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae
brenda
Alhomida, A.S.; Al-Jafari, A.A.; Duhaiman, A.S.; Rabbani, N.; Junaid, M.A.
Kinetic properties of purified carnitine acetyltransferase from the skeletal muscle of Arabian camel (Camelus dromedarius)
Biochimie
78
204-208
1996
Camelus dromedarius, Columba sp., Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Alhomida, A.S.; Duhaiman, A.S.; Al-Jafari, A.A.; Junaid, M.A.
Purification of carnitine acetyltransferase from skeletal muscle of the camel (Camelus dromedarius)
Mol. Cell. Biochem.
165
95-101
1996
Bos taurus, Camelus dromedarius, Columba sp., Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Jernejc, K.; Legisa, M.
Purification and properties of carnitine acetyltransferase from citric acid producing Aspergillus niger
Appl. Biochem. Biotechnol.
60
151-158
1996
Aspergillus niger, Bos taurus, Saccharomyces cerevisiae, Cutaneotrichosporon curvatum, Candida tropicalis, Cyberlindnera jadinii, Columba sp., Homo sapiens, Lipomyces starkeyi, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Brunner, S.; Kramar, K.; Denhardt, D.T.; Hofbauer, R.
Cloning and characterization of murine carnitine acetyltransferase: evidence for a requirement during cell cycle progression
Biochem. J.
322
403-410
1997
Saccharomyces cerevisiae, Columba sp., Homo sapiens, Mus musculus, Mus musculus (P47934), Sus scrofa, Mus musculus S3T3(ATCC CCL-92)
-
brenda
Jogl, G.; Tong, L.
Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport
Cell
112
113-122
2003
Homo sapiens, Mus musculus, Mus musculus (P47934)
brenda
Jogl, G.; Hsiao, Y.S.; Tong, L.
Structure and function of carnitine acyltransferases
Ann. N. Y. Acad. Sci.
1033
17-29
2004
Mus musculus
brenda
Hsiao, Y.S.; Jogl, G.; Tong, L.
Structural and biochemical studies of the substrate selectivity of carnitine acetyltransferase
J. Biol. Chem.
279
31584-31589
2004
Mus musculus
brenda
Ramsay, R.R.; Naismith, J.H.
A snapshot of carnitine acetyltransferase
Trends Biochem. Sci.
28
343-346
2003
Homo sapiens, Mus musculus
brenda
Hsiao, Y.S.; Jogl, G.; Tong, L.
Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates
J. Biol. Chem.
281
28480-28487
2006
Mus musculus (P47934), Mus musculus
brenda
Westin, M.A.; Hunt, M.C.; Alexson, S.E.
Short- and medium-chain carnitine acyltransferases and acyl-CoA thioesterases in mouse provide complementary systems for transport of beta-oxidation products out of peroxisomes
Cell. Mol. Life Sci.
65
982-990
2008
Mus musculus, Mus musculus 129/Sv
brenda
En-Nosse, M.; Hartmann, S.; Trinkaus, K.; Alt, V.; Stigler, B.; Heiss, C.; Kilian, O.; Schnettler, R.; Lips, K.S.
Expression of non-neuronal cholinergic system in osteoblast-like cells and its involvement in osteogenesis
Cell Tissue Res.
338
203-215
2009
Homo sapiens, Mus musculus (P47934), Mus musculus
brenda
Kienesberger, K.; Pordes, A.G.; Voelk, T.G.; Hofbauer, R.
L-carnitine and PPARalpha-agonist fenofibrate are involved in the regulation of carnitine acetyltransferase (CrAT) mRNA levels in murine liver cells
BMC Genomics
15
514
2014
Mus musculus
brenda
Davies, M.N.; Kjalarsdottir, L.; Thompson, J.W.; Dubois, L.G.; Stevens, R.D.; Ilkayeva, O.R.; Brosnan, M.J.; Rolph, T.P.; Grimsrud, P.A.; Muoio, D.M.
The acetyl group buffering action of carnitine acetyltransferase offsets macronutrient-induced lysine acetylation of mitochondrial proteins
Cell Rep.
14
243-254
2016
Mus musculus
brenda
Miyata, Y.; Shimomura, I.
Metabolic flexibility and carnitine flux: The role of carnitine acyltransferase in glucose homeostasis
J. Diabetes Investig.
4
247-249
2013
Mus musculus
brenda
Altamimi, T.R.; Thomas, P.D.; Darwesh, A.M.; Fillmore, N.; Mahmoud, M.U.; Zhang, L.; Gupta, A.; Al Batran, R.; Seubert, J.M.; Lopaschuk, G.D.
Cytosolic carnitine acetyltransferase as a source of cytosolic acetyl-CoA a possible mechanism for regulation of cardiac energy metabolism
Biochem. J.
475
959-976
2018
Mus musculus (P47934), Mus musculus
brenda
Reichenbach, A.; Stark, R.; Mequinion, M.; Denis, R.R.G.; Goularte, J.F.; Clarke, R.E.; Lockie, S.H.; Lemus, M.B.; Kowalski, G.M.; Bruce, C.R.; Huang, C.; Schittenhelm, R.B.; Mynatt, R.L.; Oldfield, B.J.; Watt, M.J.; Luquet, S.; Andrews, Z.B.
AgRP neurons require carnitine acetyltransferase to regulate metabolic flexibility and peripheral nutrient partitioning
Cell Rep.
22
1745-1759
2018
Mus musculus (P47934)
brenda