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Literature summary for 2.3.1.7 extracted from
- Properties of purified carnitine acyltransferases of mouse liver peroxisomes (1984), J. Biol. Chem., 259, 13089-13095.
General Stability
| General Stability | Organism |
|---|---|
| proteolytic degradation can occur during purification from liver | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-carnitine | - |
Bos taurus |  |
| D-carnitine | - |
Mus musculus | |
| malonyl-CoA | - |
Rattus norvegicus | |
| Zn2+ | - |
Bos taurus | |
| Zn2+ | inhibition only in reverse direction | Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0153 | - |
CoASH | - |
Mus musculus | |
| 0.0191 | - |
octanoyl-CoA | - |
Mus musculus | |
| 0.02 | - |
hexanoyl-CoA | - |
Mus musculus | |
| 0.0287 | - |
decanoyl-CoA | - |
Mus musculus | |
| 0.086 | - |
carnitine | - |
Mus musculus | |
| 0.121 | - |
L-carnitine | cosubstrate butanoyl-CoA | Mus musculus | |
| 0.344 | - |
L-carnitine | cosubstrate hexanoyl-CoA | Mus musculus | |
| 0.395 | - |
L-carnitine | cosubstrate octanoyl-CoA | Mus musculus | |
| 0.519 | - |
L-carnitine | cosubstrate decanoyl-CoA | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Mus musculus | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Torulopsis bovina | 5739 | - |
| peroxisome | - |
Mus musculus | 5777 | - |
| peroxisome | - |
Rattus norvegicus | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 25000 | - |
1 * 34000 + 1 * 25000, purified from mitochondrial fraction of liver, rats fed on a diet containing ethyl p-chlorophenoxyisobutyrate, SDS-PAGE | Rattus norvegicus |
| 34000 | - |
1 * 34000 + 1 * 25000, purified from mitochondrial fraction of liver, rats fed on a diet containing ethyl p-chlorophenoxyisobutyrate, SDS-PAGE | Rattus norvegicus |
| 60000 | - |
gel filtration | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + carnitine | Mus musculus | - |
O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | Rattus norvegicus | - |
O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | Bos taurus | - |
O-acetylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Mus musculus | - |
acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Rattus norvegicus | - |
acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Bos taurus | - |
acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Torulopsis bovina | - |
acylcarnitine + CoASH | - |
r | |
| acylcarnitine + CoASH | Mus musculus | - |
acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | Rattus norvegicus | - |
acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | Bos taurus | - |
acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | Torulopsis bovina | - |
acyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Mus musculus | - |
acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Rattus norvegicus | - |
acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Bos taurus | - |
acetyl-CoA + carnitine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
beef | - |
| Mus musculus | - |
mouse | - |
| Mus musculus | - |
swiss mice | - |
| Rattus norvegicus | - |
rat | - |
| Rattus norvegicus | - |
Sprague-Dawley | - |
| Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley | - |
| Torulopsis bovina | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Mus musculus | - |
| heart | - |
Rattus norvegicus | - |
| heart | - |
Bos taurus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + carnitine | - |
Mus musculus | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | - |
Rattus norvegicus | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | - |
Bos taurus | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Mus musculus | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Rattus norvegicus | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Bos taurus | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Torulopsis bovina | O-acetylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Mus musculus | acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Rattus norvegicus | acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Bos taurus | acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Torulopsis bovina | acylcarnitine + CoASH | - |
r | |
| acylcarnitine + CoASH | - |
Mus musculus | acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | - |
Rattus norvegicus | acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | - |
Bos taurus | acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | - |
Torulopsis bovina | acyl-CoA + carnitine | - |
r | |
| decanoyl-CoA + carnitine | - |
Mus musculus | decanoylcarnitine + CoASH | - |
r | |
| decanoyl-CoA + carnitine | - |
Rattus norvegicus | decanoylcarnitine + CoASH | - |
r | |
| decanoylcarnitine + CoASH | - |
Mus musculus | decanoyl-CoA + carnitine | - |
r | |
| decanoylcarnitine + CoASH | - |
Rattus norvegicus | decanoyl-CoA + carnitine | - |
r | |
| hexanoyl-CoA + carnitine | - |
Mus musculus | hexanoylcarnitine + CoASH | - |
r | |
| hexanoyl-CoA + carnitine | - |
Rattus norvegicus | hexanoylcarnitine + CoASH | - |
r | |
| hexanoylcarnitine + CoASH | - |
Mus musculus | hexanoyl-CoA + carnitine | - |
r | |
| hexanoylcarnitine + CoASH | - |
Rattus norvegicus | hexanoyl-CoA + carnitine | - |
r | |
| additional information | - |
Rattus norvegicus | ? | - |
? | |
| additional information | no carnitine acyltransferase activity with acyl CoAs of carbon chain lengths greater than 3 | Torulopsis bovina | ? | - |
? | |
| n-butyryl-CoA + carnitine | - |
Mus musculus | n-butyrylcarnitine + CoASH | - |
r | |
| n-butyryl-CoA + carnitine | - |
Rattus norvegicus | n-butyrylcarnitine + CoASH | - |
r | |
| n-butyryl-CoA + carnitine | - |
Bos taurus | n-butyrylcarnitine + CoASH | - |
r | |
| n-butyrylcarnitine + CoASH | - |
Mus musculus | n-butyryl-CoA + carnitine | - |
r | |
| n-butyrylcarnitine + CoASH | - |
Rattus norvegicus | n-butyryl-CoA + carnitine | - |
r | |
| n-butyrylcarnitine + CoASH | - |
Bos taurus | n-butyryl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Mus musculus | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Rattus norvegicus | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Bos taurus | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Torulopsis bovina | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Mus musculus | acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Rattus norvegicus | acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Bos taurus | acetyl-CoA + carnitine | - |
r | |
| octanoyl-CoA + carnitine | - |
Mus musculus | octanoylcarnitine + CoASH | - |
r | |
| octanoyl-CoA + carnitine | - |
Rattus norvegicus | octanoylcarnitine + CoASH | - |
r | |
| octanoyl-CoA + carnitine | - |
Bos taurus | octanoylcarnitine + CoASH | - |
r | |
| octanoylcarnitine + CoASH | - |
Mus musculus | octanoyl-CoA + carnitine | - |
r | |
| octanoylcarnitine + CoASH | - |
Rattus norvegicus | octanoyl-CoA + carnitine | - |
r | |
| octanoylcarnitine + CoASH | - |
Bos taurus | octanoyl-CoA + carnitine | - |
r | |
| propionyl-CoA + L-(-)carnitine | - |
Mus musculus | propionylcarnitine + CoASH | - |
r | |
| propionyl-CoA + L-(-)carnitine | - |
Rattus norvegicus | propionylcarnitine + CoASH | - |
r | |
| propionyl-CoA + L-(-)carnitine | - |
Bos taurus | propionylcarnitine + CoASH | - |
r | |
| propionylcarnitine + CoASH | - |
Mus musculus | propionyl-CoA + L-(-)carnitine | - |
r | |
| propionylcarnitine + CoASH | - |
Rattus norvegicus | propionyl-CoA + L-(-)carnitine | - |
r | |
| propionylcarnitine + CoASH | - |
Bos taurus | propionyl-CoA + L-(-)carnitine | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 1 * 34000 + 1 * 25000, purified from mitochondrial fraction of liver, rats fed on a diet containing ethyl p-chlorophenoxyisobutyrate, SDS-PAGE | Rattus norvegicus |
| monomer | - |
Rattus norvegicus |
| monomer | - |
Bos taurus |
| monomer | 1 * 60000, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CAT | - |
Mus musculus |
| CAT | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Mus musculus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 10 | - |
Mus musculus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1 | - |
D-carnitine | - |
Mus musculus | |
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