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Literature summary for 2.3.1.7 extracted from

  • Reichenbach, A.; Stark, R.; Mequinion, M.; Denis, R.R.G.; Goularte, J.F.; Clarke, R.E.; Lockie, S.H.; Lemus, M.B.; Kowalski, G.M.; Bruce, C.R.; Huang, C.; Schittenhelm, R.B.; Mynatt, R.L.; Oldfield, B.J.; Watt, M.J.; Luquet, S.; Andrews, Z.B.
    AgRP neurons require carnitine acetyltransferase to regulate metabolic flexibility and peripheral nutrient partitioning (2018), Cell Rep., 22, 1745-1759 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus P47934
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Source Tissue

Source Tissue Comment Organism Textmining
neuron Agouti-related peptide neuron Mus musculus
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Synonyms

Synonyms Comment Organism
CRAT
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Mus musculus

General Information

General Information Comment Organism
physiological function Crat deletion in Aguoti-related peptide neurons reduces food intake and feeding behavior and increases glycerol supply to the liver during fasting, as a gluconeogenic substrate. Crat deletion increases peripheral fatty acid substrate utilization and attenuates the switch to glucose utilization after refeeding. Crat regulates protein acetylation and metabolic processing Mus musculus