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Information on EC 2.3.1.23 - 1-acylglycerophosphocholine O-acyltransferase and Organism(s) Homo sapiens

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EC Tree
IUBMB Comments
Acts preferentially with unsaturated acyl-CoA derivatives. 1-Acyl-sn-glycero-3-phosphoinositol can also act as acceptor.
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Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
1-acyl-sn-glycero-3-phosphocholine acyltransferase, 1-acylglycerophosphocholine acyltransferase, 1-AGPAT7, acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase, acyl coenzyme A-monoacylphosphatidylcholine acyltransferase, acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase, acyl-CoA:glycerophosphocholine acyltransferase, acyl-CoA:lysophosphatidylcholine acyltransferase, acyl-CoA:lysophosphatidylethanolamine acyltransferase 2, acyl-CoA:lysophospholipid acyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1-acyl-sn-glycero-3-phosphocholine acyltransferase
-
-
-
-
1-acylglycerophosphocholine acyltransferase
-
acyl coenzyme A-monoacylphosphatidylcholine acyltransferase
-
-
-
-
acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase
-
-
-
-
acyl-CoA:lysophosphatidylethanolamine acyltransferase 2
-
acyl-CoA:lysophospholipid acyltransferase
-
acyltransferase, lysolecithin
-
-
-
-
LPAT
-
-
LPCAT
LPCAT3
LPGAT1
-
-
lysolecithin acyltransferase
-
-
-
-
lysophosphatide acyltransferase
-
-
-
-
lysophosphatidylcholine acyltransferase
lysophosphatidylcholine acyltransferase 1
-
lysophosphatidylcholine acyltransferase 3
lysophosphocholine acyltransferase 1
-
lysophosphocholine acyltransferase 2
-
lysophosphocholine acyltransferase 3
-
lysophosphocholine acyltransferase 4
-
lysophospholipid acyltransferase
lysophospholipid acyltransferases
-
-
membrane-bound O-acyltransferase 5
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
Acts preferentially with unsaturated acyl-CoA derivatives. 1-Acyl-sn-glycero-3-phosphoinositol can also act as acceptor.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-64-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-acyl-2-lysophosphatidylethanolamine + oleoyl-CoA
1-acyl-2-oleoylphosphatidylethanolamine + CoA
show the reaction diagram
-
-
-
?
1-myristoyl-lysophosphatidylcholine + palmitoyl-CoA
CoA + 1-myristoyl-2-palmitoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
1-oleoyl-lysophosphatidylcholine + palmitoyl-CoA
CoA + 1-oleoyl-2-palmitoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + alpha-linolenoyl-CoA
1-palmitoyl-2-alpha-linolenoylphosphatidylcholine + CoA
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylcholine + CoA
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + linoleoyl-CoA
1-palmitoyl-2-linoleoylphosphatidylcholine + CoA
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + oleoyl-CoA
1-palmitoyl-2-oleoylphosphatidylcholine + CoA
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + palmitoyl-CoA
1,2-dipalmitoylphosphatidylcholine + CoA
show the reaction diagram
-
activity observed only in the presence of phosphatidylcholine (1 mg/ml)
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + stearoyl-CoA
1-palmitoyl-2-stearoylphosphatidylcholine + CoA
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylglycerol + palmitoyl-CoA
1,2-dipalmitoylphosphatidylglycerol + CoA
show the reaction diagram
-
activity observed only in the presence of phosphatidylcholine (1 mg/ml)
-
-
?
1-palmitoyl-2-lysophosphatidylserine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylserine + CoA
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylserine + linoleoyl-CoA
1-palmitoyl-2-linoleoylphosphatidylserine + CoA
show the reaction diagram
-
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + arachidonoyl-CoA
CoA + 1-palmitoyl-2-arachidonoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + lauroyl-CoA
CoA + 1-palmitoyl-2-lauroylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + linoleoyl-CoA
CoA + 1-palmitoyl-2-linoleoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + n-octanoyl-CoA
CoA + 1-palmitoyl-2-octanoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + oleoyl-CoA
CoA + 2-oleoyl-1-palmitoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + palmitoyl-CoA
CoA + 1,2-dipalmitoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + stearoyl-CoA
CoA + 1-palmitoyl-2-stearoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
1-stearoyl-lysophosphatidylcholine + palmitoyl-CoA
CoA + 1-stearoyl-2-palmitoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
show the reaction diagram
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
arachidonoyl-CoA + 1-arachidoyl-2-lysophosphatidylcholine
CoA + 2-arachidonoyl-1-arachidoylphosphatidylcholine
show the reaction diagram
-
-
-
?
arachidonoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine
CoA + 2-arachidonoyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
show the reaction diagram
LPCAT3 acylates 1-O-alkyl-sn-glycero-3-phosphocholine with arachidonyl-CoA but not with acetyl-CoA
-
-
?
arachidonoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
CoA + 2-arachidonoyl-1-palmitoylphosphatidylcholine
show the reaction diagram
-
-
-
?
arachidonoyl-CoA + 1-palmitoyl-2-lysophosphatidylethanolamine
CoA + 2-arachidonoyl-1-palmitoylphosphatidylethanolamine
show the reaction diagram
lysophosphatidylethanolamine acylation is evident. But no significant activity of acylation is detected when 16:0-lysophosphatidylglycerol is used as substrate
-
-
?
arachidonoyl-CoA + 1-stearoyl-2-lysophosphatidylcholine
CoA + 2-arachidonoyl-1-stearoylphosphatidylcholine
show the reaction diagram
-
-
-
?
arachidonoyl-CoA + palmitoyl-lysophosphatidylcholine
CoA + 2-arachidonoyl-1-palmitoylphosphatidylcholine
show the reaction diagram
-
-
-
?
linoleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
linoleoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
CoA + 1-palmitoyl-2-linoleoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
linoleoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
CoA + 2-linoleoyl-1-palmitoylphosphatidylcholine
show the reaction diagram
-
-
-
?
lyso-platelet-activating factor + acetyl-CoA
platelet-activating factor + CoA
show the reaction diagram
-
activity observed only in the presence of phosphatidylcholine (1 mg/ml)
-
-
?
lysophosphatidylcholine + acyl-CoA
phosphatidylcholine + CoA
show the reaction diagram
oleoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
CoA + 2-oleoyl-1-palmitoylphosphatidylcholine
show the reaction diagram
-
-
-
?
oleoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
-
?
oleoyl-CoA + palmitoyl-lysophosphatidylcholine
CoA + 2-oleoyl-1-palmitoylphosphatidylcholine
show the reaction diagram
-
-
-
?
oleoyl-CoA + sn-1-myristoyl-lysophosphatidylcholine
CoA + 1-myristoyl-2-oleoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
oleoyl-CoA + sn-1-stearoyl-lysophosphatidylcholine
CoA + 2-oleoyl-1-stearoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
oleyl-CoA + sn-1-oleoyl-lysophosphatidylcholine
CoA + 1,2-dioleoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
CoA + 1,2-dipalmitoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
CoA + 2-palmitoyl-1-palmitoylphosphatidylcholine
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
palmitoyl-CoA + sn-1-myristoyl-lysophosphatidylcholine
CoA + 1-myristoyl-2-palmitoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
palmitoyl-CoA + sn-1-oleoyl-lysophosphatidylcholine
CoA + 1-oleoyl-2-palmitoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
palmitoyl-CoA + sn-1-stearoyl-lysophosphatidylcholine
CoA + 1-stearoyl-2-palmitoylphosphatidylcholine
show the reaction diagram
-
-
-
-
?
stearoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
CoA + 2-stearoyl-1-palmitoylphosphatidylcholine
show the reaction diagram
-
-
-
?
stearoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
required
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
18-(4'-azido-2'-hydroxybenzoylamino)-oleic acid
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0.4 mM; 73% inhibition, reversible inhibition in the dark, irreversible inactivation after photolysis, used as photoaffinity label
2-[5-(thiophen-3-yl)pyridin-3-yl]ethanol
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non-competitive
CI-976
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inhibition of Golgi complex-associated LPAT activity by the drug CI-976 stimulates Golgi tubule formation and subsequent redistribution of resident Golgi proteins to the endoplasmic reticulum, it prevents recycling of transferrin receptors, but does not inhibit transferrin uptake, overview
lipopolysaccharide
suppresses the enzyme activity of isozyme LPCAT3 toward linoleoyl-CoA and arachidonoyl-CoA in phorbol 12-myristate 13-acetate-treated U-937 cells
N-ethylmaleimide
-
15 min preincubation on ice with 40 mM: activity completely abolished
T0901317
a liver X recpeotr agonist
thimerosal
-
-
additional information
-
enzyme activity can be inhibited by high levels of acyl acceptors
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.7219
1-palmitoyl-lysophosphatidylcholine
-
Vmax: 6364 nmol/min/mg protein
0.214
alpha-linolenoyl-CoA
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28°C, no cooperativity: Hill number 1.0
0.005 - 0.7156
Arachidonoyl-CoA
0.2014
linoleoyl-CoA
-
Vmax: 18148 nmol/min/mg protein
0.0131
lysophosphatidylcholine
-
cooperativity: Hill number 1.7
0.08
lysophosphatidylethanolamine
-
0.00045 - 0.07268
oleoyl-CoA
0.04129
palmitoyl-CoA
-
Vmax: 1782 nmol/min/mg protein
0.0021 - 0.232
stearoyl-CoA
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.02
alpha-linolenoyl-CoA
-
28°C, no cooperativity: Hill number 1.0
0.005 - 0.16
Arachidonoyl-CoA
0.12 - 0.27
oleoyl-CoA
0.02 - 0.16
stearoyl-CoA
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0001
-
activity in freshly prepared erythrocyte membranes with palmitoyl-CoA as acyl donor
0.0006
-
activity in stored erythrocyte membranes with palmitoyl-CoA as acyl donor
0.0007
-
activity in freshly prepared erythrocyte membranes with oleoyl-CoA as acyl donor
0.0008
-
activity in stored erythrocyte membranes with oleoyl-CoA as acyl donor
0.006
-
substrate: stearoyl-CoA, 37°C, cooperativity: Hill number 3.7
0.05
-
substrate: stearoyl-CoA, 28°C, cooperativity: Hill number 2.7
0.082
-
substrate: arachidonoyl-CoA, 37°C, cooperativity: Hill number 2.0
0.087
-
substrate: oleoyl-CoA, 37°C, cooperativity: Hill number 1.6
0.268
-
substrate: alpha-linolenoyl-CoA, 28°C, no cooperativity: Hill number 1.0
0.323
-
substrate: stearoyl-CoA, 37°C, cooperativity: Hill number 1.4
0.486
-
substrate: lysophosphatidylcholine, cooperativity: Hill number 1.7
0.529
-
substrate: arachidonoyl-CoA, 28°C, cooperativity: Hill number 2.0
0.759
-
substrate: oleoyl-CoA, 28°C, cooperativity: Hill number 2.0
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
-
assay at
additional information
-
assay carried out at room temperature
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
high expression of both isoforms LCAT1 and LCAT2; high expression of both isoforms LCAT1 and LCAT2
Manually annotated by BRENDA team
-
by retrieving LPCAT3 expression pattern from Genevestigator
Manually annotated by BRENDA team
-
determined by RT-PCR analysis
Manually annotated by BRENDA team
-
very low level of expression
Manually annotated by BRENDA team
-
northern blot analysis
Manually annotated by BRENDA team
low expression of isoform LCAT1
Manually annotated by BRENDA team
-
priming of Mono-Mac-6 cells by IFNgamma appears to involve LPCAT
Manually annotated by BRENDA team
-
northern blot analysis
Manually annotated by BRENDA team
-
highly expressed, detected by Northern blot analysis
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
associated
Manually annotated by BRENDA team
in addition to endoplasmic reticulum, both isoforms LCAT1 and LCAT2 localize to lipid droplets, which consist of a core of neutral lipids surrounded by a monolayer of phospholipid, mainly phosphatidylcholine. This dual localization is enabled by the monotopic topology of the enzymes with both termini facing the cytoplasm, irrespective of supplementation with oleic acid. Lipid droplets have the ability to locally synthesize phosphatidylcholine and this activity correlates with the LPCAT1 and -2 expression levels; in addition to endoplasmic reticulum, both isoforms LCAT1 and LCAT2 localize to lipid droplets, which consist of a core of neutral lipids surrounded by a monolayer of phospholipid, mainly phosphatidylcholine. This dual localization is enabled by the monotopic topology of the enzymes with both termini facing the cytoplasm, irrespective of supplementation with oleic acid. Lipid droplets have the ability to locally synthesize phosphatidylcholine and this activity correlates with the LPCAT1 and -2 expression levels
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
the liver X receptor-mediated induction of enzyme LPCAT3 specifically regulates the metabolism of arachidonic acid, the precursor of key inflammatory mediators, such as eicosanoids. Liver X receptor and lysophosphatidylcholine acyltransferase 3 modulate the fatty acid composition of human macrophages, overview
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
PCAT1_HUMAN
534
1
59151
Swiss-Prot
PCAT2_HUMAN
544
1
60208
Swiss-Prot
MBOA5_HUMAN
487
7
56035
Swiss-Prot
LPCT4_HUMAN
524
1
57219
Swiss-Prot
MBOA2_HUMAN
520
6
59527
Swiss-Prot
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
43000
-
x * 43000, SDS-PAGE
56000
57200
x * 57200, calculated
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C211F
-
C211 is essential for activity
C211R
-
C211 is essential for activity
C211S
-
C211 is essential for activity
M427T
-
naturally occuring mutation, does not significantly affect the activity or function
N213A
-
putative N-glycosylation site
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
partially purified
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in COS-7 cell and SW-480 cell
-
expressed in Saccharomyces cerevisiae
-
expressed in Sf9 insect cell
-
expressed in yeast
-
expression in A-431 cell and COS-7 cell; expression in A-431 cell, COS-7 cell, and Hu-H7 cell
expression in COS-7 cells and in Sf9 insect cells
-
FLAG-tagged version expressed in HEK293T cell, expressed in Escherichia coli BL21 (DE3)
FLAG-tegged version expressed in CHO-K1 cell, expressed in HeLa cell
-
gene LPCAT3, quantitative real-time RT-PCR enzyme expression analysis
gene LPCAT3, real-time PCR enzyme expression analysis
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme LPCAT3 is upregulated by liver X receptor LXR agonists, e.g. T0901317, in human macrophages
lipopolysaccharide significantly downregulates the mRNA expression of isozyme LPCAT3
upregulated in colorectal adenocarcinomas (compared to normal mucosas)
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pharmacology
the enzyme is a potential therapeutic targets for the regulation of immune and inflammatory disorders
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gehring, L.; Haase, D.; Habben, K.; Kerkhoff, C.; Meyer, H.H.; Kaever, V.
Synthesis of an unsaturated fatty acid analog (18-(4'-azido-2'-hydroxybenzoylamino)-oleic acid) and its interaction with lysophosphatidylcholine: acyl-CoA-O-acyltransferase
J. Lipid Res.
39
1118-1126
1998
Homo sapiens
Manually annotated by BRENDA team
Rusnak, A.; Coghlan, G.; Zelinski, T.; Hatch, G.M.
Incorporation of fatty acids into phosphatidylcholine is reduced during storage of human erythrocytes: evidence for distinct lysophosphatidylcholine acyltransferases
Mol. Cell. Biochem.
213
137-143
2000
Homo sapiens
Manually annotated by BRENDA team
Neville, N.T.; Parton, J.; Harwood, J.L.; Jackson, S.K.
The activities of monocyte lysophosphatidylcholine acyltransferase and coenzyme A-independent transacylase are changed by the inflammatory cytokines tumor necrosis factor alpha and interferon gamma
Biochim. Biophys. Acta
1733
232-238
2005
Homo sapiens
Manually annotated by BRENDA team
Jackson, S.K.; Parton, J.
Lysophospholipid acyltransferases in monocyte inflammatory responses and sepsis
Immunobiology
209
31-38
2004
Homo sapiens
Manually annotated by BRENDA team
Yang, Y.; Cao, J.; Shi, Y.
Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase
J. Biol. Chem.
279
55866-55874
2004
Homo sapiens
Manually annotated by BRENDA team
Chambers, K.; Judson, B.; Brown, W.J.
A unique lysophospholipid acyltransferase (LPAT) antagonist, CI-976, affects secretory and endocytic membrane trafficking pathways
J. Cell Sci.
118
3061-3071
2005
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Zhao, Y.; Chen, Y.Q.; Bonacci, T.M.; Bredt, D.S.; Li, S.; Bensch, W.R.; Moller, D.E.; Kowala, M.; Konrad, R.J.; Cao, G.
Identification and characterization of a major liver lysophosphatidylcholine acyltransferase
J. Biol. Chem.
283
8258-8265
2008
Homo sapiens
Manually annotated by BRENDA team
Kazachkov, M.; Chen, Q.; Wang, L.; Zou, J.
Substrate preferences of a lysophosphatidylcholine acyltransferase highlight its role in phospholipid remodeling
Lipids
43
895-902
2008
Homo sapiens, Homo sapiens (Q6P1A2)
Manually annotated by BRENDA team
Matsuda, S.; Inoue, T.; Lee, H.C.; Kono, N.; Tanaka, F.; Gengyo-Ando, K.; Mitani, S.; Arai, H.
Member of the membrane-bound O-acyltransferase (MBOAT) family encodes a lysophospholipid acyltransferase with broad substrate specificity
Genes Cells
13
879-888
2008
Caenorhabditis elegans, Caenorhabditis elegans (O01925), Homo sapiens, Homo sapiens (Q6P1A2)
Manually annotated by BRENDA team
Cao, J.; Shan, D.; Revett, T.; Li, D.; Wu, L.; Liu, W.; Tobin, J.F.; Gimeno, R.E.
Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2
J. Biol. Chem.
283
19049-19057
2008
Homo sapiens (Q643R3)
Manually annotated by BRENDA team
Gijon, M.A.; Riekhof, W.R.; Zarini, S.; Murphy, R.C.; Voelker, D.R.
Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils
J. Biol. Chem.
283
30235-30245
2008
Homo sapiens, Homo sapiens (Q6P1A2)
Manually annotated by BRENDA team
Shindou, H.; Shimizu, T.
Acyl-CoA:lysophospholipid acyltransferases
J. Biol. Chem.
284
1-5
2009
Homo sapiens (Q6P1A2), Homo sapiens (Q6ZWT7), Homo sapiens (Q7L5N7), Homo sapiens (Q8NF37), Mus musculus (Q3TFD2), Mus musculus (Q8BYI6), Mus musculus (Q8R3I2), Mus musculus (Q91V01)
Manually annotated by BRENDA team
Perez-Chacon, G.; Astudillo, A.M.; Ruiperez, V.; Balboa, M.A.; Balsinde, J.
Signaling role for lysophosphatidylcholine acyltransferase 3 in receptor-regulated arachidonic acid reacylation reactions in human monocytes
J. Immunol.
184
1071-1078
2010
Homo sapiens
Manually annotated by BRENDA team
Jain, S.; Zhang, X.; Khandelwal, P.J.; Saunders, A.J.; Cummings, B.S.; Oelkers, P.
Characterization of human lysophospholipid acyltransferase 3
J. Lipid Res.
50
1563-1570
2009
Homo sapiens, Homo sapiens (Q6P1A2)
Manually annotated by BRENDA team
Harayama, T.; Shindou, H.; Shimizu, T.
Biosynthesis of phosphatidylcholine by human lysophosphatidylcholine acyltransferase 1
J. Lipid Res.
50
1824-1831
2009
Homo sapiens, Homo sapiens (Q8NF37)
Manually annotated by BRENDA team
Mansilla, F.; da Costa, K.A.; Wang, S.; Kruh?ffer, M.; Lewin, T.M.; Orntoft, T.F.; Coleman, R.A.; Birkenkamp-Demtroeder, K.
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) overexpression in human colorectal cancer
J. Mol. Med.
87
85-97
2009
Homo sapiens, Homo sapiens (Q8NF37)
Manually annotated by BRENDA team
Jackson, S.K.; Abate, W.; Tonks, A.J.
Lysophospholipid acyltransferases: novel potential regulators of the inflammatory response and target for new drug discovery
Pharmacol. Ther.
119
104-114
2008
Bos taurus, Homo sapiens (Q8NF37), Mus musculus (Q3TFD2), Rattus norvegicus
Manually annotated by BRENDA team
Moessinger, C.; Kuerschner, L.; Spandl, J.; Shevchenko, A.; Thiele, C.
Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine
J. Biol. Chem.
286
21330-21339
2011
Homo sapiens, Homo sapiens (Q7L5N7), Homo sapiens (Q8NF37)
Manually annotated by BRENDA team
Ishibashi, M.; Varin, A.; Filomenko, R.; Lopez, T.; Athias, A.; Gambert, P.; Blache, D.; Thomas, C.; Gautier, T.; Lagrost, L.; Masson, D.
Liver X receptor regulates arachidonic acid distribution and eicosanoid release in human macrophages: a key role for lysophosphatidylcholine acyltransferase 3
Arterioscler. Thromb. Vasc. Biol.
33
1171-1179
2013
Homo sapiens, Homo sapiens (Q6P1A2)
Manually annotated by BRENDA team
Taniguchi, K.; Hikiji, H.; Okinaga, T.; Hashidate-Yoshida, T.; Shindou, H.; Ariyoshi, W.; Shimizu, T.; Tominaga, K.; Nishihara, T.
Essential role of lysophosphatidylcholine acyltransferase 3 in the induction of macrophage polarization in PMA-treated U937 cells
J. Cell. Biochem.
116
2840-2848
2015
Homo sapiens (Q6P1A2)
Manually annotated by BRENDA team
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