Literature summary for 2.3.1.23 extracted from

Beilstein, F.; Lemasson, M.; Pene, V.; Rainteau, D.; Demignot, S.; Rosenberg, A.R.
Lysophosphatidylcholine acyltransferase 1 is downregulated by hepatitis C virus impact on production of lipo-viro-particles (2017), Gut, 66, 2160-2169 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8NF37	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	primary	Homo sapiens	-
Huh-7.5.1 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
LPCAT1	-	Homo sapiens
lysophosphatidylcholine acyltransferase 1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	upon hepatitis C virus (HCV) infection, both Huh-7.5.1 cells and primary human hepatocytes (PHH) show decreased levels of LPCAT1 transcript and protein, consistent with transcriptional downregulation. LPCAT1 depletion in either naive or infected Huh-7.5.1 cells results in altered lipid metabolism characterised by lipid droplet remodelling, increased triacylglycerol storage, and increased secretion of VLDL. In infected Huh-7.5.1 cells or PHH, LPCAT1 depletion increases production of the viral particles of lowest density and highest infectivity	Homo sapiens
physiological function	lysophosphatidylcholine acyltransferase 1 (LPCAT1), as an LD phospholipid-remodelling enzyme, plays a role in liver lipid metabolism and HCV infectious cycle	Homo sapiens

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Release 2023.1 (January 2023)