Any feedback?
Literature summary for 2.3.1.23 extracted from
- An accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases (2019), Biochim. Biophys. Acta, 1864, 1053-1060 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene LCLAT1, recombinant expression in HEK-293 cells | Mus musculus |
| gene LPCAT1, functional recombinant expression in HEK-293 cells | Mus musculus |
| gene LPCAT1, functional recombinant expression in HEK-293 cells | Homo sapiens |
| gene LPCAT3, recombinant expression in HEK-293 cells | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mus musculus | 16020 | - |
| membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + 1-acyl-lysophosphatidylcholine | Mus musculus | - |
CoA + 1,2-diacyl-lysophosphatidylcholine | - |
? |  |
| acyl-CoA + 1-acyl-sn-lysophosphatidylcholine | Mus musculus | - |
CoA + 1,2-diacyl-sn-lysophosphatidylcholine | - |
? | |
| acyl-CoA + 1-acyl-sn-lysophosphatidylcholine | Homo sapiens | - |
CoA + 1,2-diacyl-sn-lysophosphatidylcholine | - |
? | |
| acyl-CoA + 2-acyl-sn-lysophosphatidylglycerol | Mus musculus | - |
CoA + 1,2-diacyl-sn-lysophosphatidylglycerol | - |
? | |
| additional information | Mus musculus | LPCAT3 is critical for introduction of polyunsaturated fatty acids (PUFAs), especially arachidonic acid (20:4) at the sn-2 position of various LPLs, generating various types of arachidonoyl phospholipids | ? | - |
- |
|
| additional information | Mus musculus | LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin | ? | - |
- |
|
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q8NF37 | - |
- |
| Mus musculus | Q3TFD2 | - |
- |
| Mus musculus | Q3UN02 | - |
- |
| Mus musculus | Q91V01 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293A cell | - |
Mus musculus | - |
| HEK-293A cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + 1-acyl-lysophosphatidylcholine | - |
Mus musculus | CoA + 1,2-diacyl-lysophosphatidylcholine | - |
? | |
| acyl-CoA + 1-acyl-sn-lysophosphatidylcholine | - |
Mus musculus | CoA + 1,2-diacyl-sn-lysophosphatidylcholine | - |
? | |
| acyl-CoA + 1-acyl-sn-lysophosphatidylcholine | - |
Homo sapiens | CoA + 1,2-diacyl-sn-lysophosphatidylcholine | - |
? | |
| acyl-CoA + 2-acyl-sn-lysophosphatidylglycerol | - |
Mus musculus | CoA + 1,2-diacyl-sn-lysophosphatidylglycerol | - |
? | |
| arachidonoyl-CoA + 1-stearoyl-lysophosphatidylcholine | preferred reaction | Mus musculus | CoA + 1-stearoyl-2-arachidonoyl-lysophosphatidylcholine | - |
? | |
| arachidonoyl-CoA + 2-stearoyl-lysophosphatidylcholine | low activity, cf. EC 2.3.1.62 | Mus musculus | CoA + 1-arachidonoyl-2-stearoyl-lysophosphatidylcholine | - |
? | |
| additional information | LPCAT3 is critical for introduction of polyunsaturated fatty acids (PUFAs), especially arachidonic acid (20:4) at the sn-2 position of various LPLs, generating various types of arachidonoyl phospholipids | Mus musculus | ? | - |
- |
|
| additional information | LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin | Mus musculus | ? | - |
- |
|
| additional information | development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LPCAT1 introduces palmitic acid both at the sn-1 and sn-2 positions of palmitoyl-LPC | Mus musculus | ? | - |
- |
|
| additional information | development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LPCAT1 introduces palmitic acid both at the sn-1 and sn-2 positions of palmitoyl-lysophosphatidylcholine (LPC). sn-1-Palmitoyl LPC appears to have a slightly higher affinity for LPCAT1 than sn-2-palmitoyl LPC, while sn-2-palmitoyl LPC has a higher turnover rate | Homo sapiens | ? | - |
- |
|
| additional information | development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LPCAT3 introduces arachidonic acid predominantly at the sn-2 position of lysophosphatidylcholine (LPC) | Mus musculus | ? | - |
- |
|
| additional information | development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LYCAT introduces stearic acid predominantly at the sn-1 position of LPG. The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin | Mus musculus | ? | - |
- |
|
| palmitoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine | - |
Mus musculus | CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine | - |
? | |
| palmitoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine | - |
Homo sapiens | CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine | - |
? | |
| palmitoyl-CoA + 2-palmitoyl-lysophosphatidylcholine | reaction of EC 2.3.1.62 | Homo sapiens | CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine | - |
? | |
| palmitoyl-CoA + 2-palmitoyl-sn-lysophosphatidylcholine | reaction of EC 2.3.1.62 | Mus musculus | CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine | - |
? | |
| stearoyl-CoA + 1-oleoyl-sn-lysophosphatidylglycerol | LYCAT introduces stearic acid predominantly at the sn-1 position of lysophosphatidylglycerol (LPG), cf. EC 2.3.1.62 | Mus musculus | CoA + 1-oleoyl-2-stearoyl-sn-lysophosphatidylglycerol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase 8 | UniProt | Mus musculus |
| 1-AGP acyltransferase 8 | UniProt | Mus musculus |
| 1-AGPAT 8 | UniProt | Mus musculus |
| acyl-CoA:lysocardiolipin acyltransferase 1 | - |
Mus musculus |
| AGPAT8 | - |
Mus musculus |
| Alcat1 | - |
Mus musculus |
| Lclat1 | - |
Mus musculus |
| LPC acyltransferase | - |
Mus musculus |
| LPC acyltransferase | - |
Homo sapiens |
| LPCAT1 | - |
Mus musculus |
| LPCAT1 | - |
Homo sapiens |
| LPCAT3 | - |
Mus musculus |
| LPG acyltransferase | - |
Mus musculus |
| LPGAT | - |
Mus musculus |
| LPLAT | - |
Mus musculus |
| LPLAT | - |
Homo sapiens |
| LYCAT | - |
Mus musculus |
| lysophospholipid acyltransferase | - |
Mus musculus |
| lysophospholipid acyltransferase | - |
Homo sapiens |
| More | cf. EC 2.3.1.51 and 2.3.1.62 | Mus musculus |
| More | cf. EC 2.3.1.62 | Mus musculus |
| More | cf. EC 2.3.1.62 | Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
| 7.4 | - |
assay at | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
