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Acidosis
Increased activity of renal glycine-cleavage-enzyme complex in metabolic acidosis.
Adenocarcinoma
Association of MTHFR C677T and SHMT(1) C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China.
Adenocarcinoma
Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.
Adenocarcinoma
One carbon metabolism in human lung cancer.
Adenocarcinoma
[Correlations between Serine Hydroxymethyltransferase1 C1420T Polymorphisms and Susceptibilities to Esophageal Squamous Cell Carcinoma and Gastric Cardiac Adenocarcinoma.]
Adenocarcinoma of Lung
Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity.
Adenocarcinoma of Lung
Identification of SHMT2 as a Potential Prognostic Biomarker and Correlating with Immune Infiltrates in Lung Adenocarcinoma.
Adenocarcinoma of Lung
miR-198 targets SHMT1 to inhibit cell proliferation and enhance cell apoptosis in lung adenocarcinoma.
Adenocarcinoma of Lung
MiR-218-5p Suppresses the Killing Effect of Natural Killer Cell to Lung Adenocarcinoma by Targeting SHMT1.
Adenocarcinoma of Lung
Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments.
Adenoma
Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase 1, and colorectal adenoma risk: a Dutch case-control study.
Adrenocortical Carcinoma
Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism.
Alopecia
Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis.
Anemia
Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders.
Anemia, Hypochromic
Arabidopsis photorespiratory serine hydroxymethyltransferase activity requires the mitochondrial accumulation of ferredoxin-dependent glutamate synthase.
Arthritis, Rheumatoid
Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients.
Breast Neoplasms
Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer.
Breast Neoplasms
Association of aberrations in one-carbon metabolism with molecular phenotype and grade of breast cancer.
Breast Neoplasms
Bioinformatics analysis of the serine and glycine pathway in cancer cells.
Breast Neoplasms
Circ_0072995 Promotes Cell Carcinogenesis via Up-Regulating miR-149-5p-Mediated SHMT2 in Breast Cancer.
Breast Neoplasms
Clinical significance of SHMT1 rs1979277 polymorphism in Asian solid tumors: evidence from a meta-analysis.
Breast Neoplasms
EIF2A promotes cell survival during paclitaxel treatment in vitro and in vivo.
Breast Neoplasms
ERR? activates SHMT2 transcription to enhance the resistance of breast cancer to lapatinib via modulating the mitochondrial metabolic adaption.
Breast Neoplasms
Folate-mediated one-carbon metabolism: a targeting strategy in cancer therapy.
Breast Neoplasms
Genetic polymorphisms in the one-carbon metabolism pathway and breast cancer risk: a population-based case-control study and meta-analyses.
Breast Neoplasms
Genetic variants in one-carbon metabolism genes and breast cancer risk in European American and African American women.
Breast Neoplasms
In silico analysis of the structural and functional implications of SLC19A1 R27H polymorphism.
Breast Neoplasms
Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism.
Breast Neoplasms
No association between cSHMT genotypes and the risk of breast cancer in the Nurses' Health Study.
Breast Neoplasms
Polymorphism of cytosolic serine hydroxymethyltransferase and breast cancer risk: evidence from a meta-analysis.
Breast Neoplasms
Polymorphism of cytosolic serine hydroxymethyltransferase, estrogen and breast cancer risk among Chinese women in Taiwan.
Breast Neoplasms
Population-level diversity in the association of genetic polymorphisms of one-carbon metabolism with breast cancer risk.
Breast Neoplasms
Positive correlation between expression level of mitochondrial serine hydroxymethyltransferase and breast cancer grade.
Breast Neoplasms
Prognostic and therapeutic value of mitochondrial serine hydroxyl-methyltransferase 2 as a breast cancer biomarker.
Breast Neoplasms
Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors.
Breast Neoplasms
Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis.
Breast Neoplasms
Site-specific metabolic phenotypes in metastatic breast cancer.
Breast Neoplasms
[Polymorphic variants of folate metabolizing genes (C677T and A1298C MTHFR, C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in West Siberian Region of Russia].
Carcinogenesis
Association of MTHFR C677T and SHMT(1) C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China.
Carcinogenesis
Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.
Carcinogenesis
Circ_0072995 Promotes Cell Carcinogenesis via Up-Regulating miR-149-5p-Mediated SHMT2 in Breast Cancer.
Carcinogenesis
Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting ?-catenin degradation.
Carcinogenesis
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.
Carcinogenesis
DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.
Carcinogenesis
Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma.
Carcinogenesis
Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis.
Carcinogenesis
Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-q14 amplification.
Carcinoma
Association of MTHFR C677T and SHMT(1) C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China.
Carcinoma
Deciphering tissue-based proteome signatures revealed novel subtyping and prognostic markers for thymic epithelial tumors.
Carcinoma
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma.
Carcinoma
Increased Expression of SHMT2 Is Associated With Poor Prognosis and Advanced Pathological Grade in Oral Squamous Cell Carcinoma.
Carcinoma
Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism.
Carcinoma
Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene.
Carcinoma
Polymorphisms and haplotypes of serine hydroxymethyltransferase and risk of squamous cell carcinoma of the head and neck: a case-control analysis.
Carcinoma
Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma.
Carcinoma
Silencing SHMT2 inhibits the progression of tongue squamous cell carcinoma through cell cycle regulation.
Carcinoma
The effect of L-2-amino-4-methoxy-trans-3-butenoic acid on serine hydroxymethyl transferase.
Carcinoma
[Correlations between Serine Hydroxymethyltransferase1 C1420T Polymorphisms and Susceptibilities to Esophageal Squamous Cell Carcinoma and Gastric Cardiac Adenocarcinoma.]
Carcinoma, Hepatocellular
Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Enzymic imbalance in serine metabolism in rat hepatomas.
Carcinoma, Hepatocellular
Increased Expression of Serine Hydroxymethyltransferase 2 (SHMT2) is a Negative Prognostic Marker in Patients with Hepatocellular Carcinoma and is Associated with Proliferation of HepG2 Cells.
Carcinoma, Hepatocellular
Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis.
Carcinoma, Hepatocellular
The modulation of serine metabolism in hepatoma 3924A during different phases of cellular proliferation in culture.
Carcinoma, Hepatocellular
[Serine transhydroxymethylase of cells and subcellular structures of liver and hepatoma]
Carcinoma, Ovarian Epithelial
Genetic variation in the one-carbon transfer pathway and ovarian cancer risk.
Carcinoma, Squamous Cell
Deciphering tissue-based proteome signatures revealed novel subtyping and prognostic markers for thymic epithelial tumors.
Carcinoma, Squamous Cell
Polymorphisms and haplotypes of serine hydroxymethyltransferase and risk of squamous cell carcinoma of the head and neck: a case-control analysis.
Carcinoma, Squamous Cell
Silencing SHMT2 inhibits the progression of tongue squamous cell carcinoma through cell cycle regulation.
Cardiovascular Diseases
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
Cardiovascular Diseases
Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men.
Cardiovascular Diseases
Polymorphisms in serine hydroxymethyltransferase 1 and methylenetetrahydrofolate reductase interact to increase cardiovascular disease risk in humans.
Cholangiocarcinoma
SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma.
Cleft Lip
A SHMT1 variant decreases the risk of nonsyndromic cleft lip with or without cleft palate in Chile.
Cleft Palate
A SHMT1 variant decreases the risk of nonsyndromic cleft lip with or without cleft palate in Chile.
Colonic Neoplasms
Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.
Colonic Neoplasms
Long noncoding RNA LINC01234 promotes serine hydroxymethyltransferase 2 expression and proliferation by competitively binding miR-642a-5p in colon cancer.
Colonic Neoplasms
Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk.
Colonic Neoplasms
SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer.
Colonic Neoplasms
[RETRACTED: Serine hydroxymethyl transferase 2 regulates the AMPK/mTOR pathway and induces autophagy to promote chemotherapy resistance in colon cancer cells].
Colonic Neoplasms
[Serine hydroxymethyl transferase 2 regulates the AMPK/mTOR pathway and induces autophagy to promote chemotherapy resistance in colon cancer cells].
Colorectal Neoplasms
A meta-analysis of the C1420T polymorphism in cytosolic serine hydroxymethyltransferase (SHMT1) among Caucasian colorectal cancer populations.
Colorectal Neoplasms
Association between cytosolic serine hydroxymethyltransferase (SHMT1) gene polymorphism and cancer risk: a meta-analysis.
Colorectal Neoplasms
Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting ?-catenin degradation.
Colorectal Neoplasms
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.
Colorectal Neoplasms
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
Colorectal Neoplasms
High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors.
Colorectal Neoplasms
Impact of SHMT1 polymorphism on the clinical outcome of patients with metastatic colorectal cancer treated with first-line FOLFIRI+bevacizumab.
Colorectal Neoplasms
The importance of mitochondrial folate enzymes in human colorectal cancer.
Colorectal Neoplasms
The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy.
Communicable Diseases
Cloning and characterization of Plasmodium vivax serine hydroxymethyltransferase.
Coronary Artery Disease
Oxidative Stress is Associated with Genetic Polymorphisms in One-Carbon Metabolism in Coronary Artery Disease.
Cysts
Engineered resistance and hypersusceptibility through functional metabolic studies of 100 genes in soybean to its major pathogen, the soybean cyst nematode.
Cysts
Genome reorganization of the GmSHMT gene family in soybean showed a lack of functional redundancy in resistance to soybean cyst nematode.
Cysts
Impaired folate binding of serine hydroxymethyltransferase 8 from soybean underlies resistance to the soybean cyst nematode.
Cysts
Soybean Cyst Nematode Resistance Emerged via Artificial Selection of Duplicated Serine Hydroxymethyltransferase Genes.
Down Syndrome
Polymorphism C1420T of Serine hydroxymethyltransferase gene on maternal risk for Down syndrome.
Epilepsy
A high frequency of the MTHFR 677C>T polymorphism in Scottish women with epilepsy: possible role in pathogenesis.
Esophageal Neoplasms
High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors.
Esophageal Squamous Cell Carcinoma
Association of MTHFR C677T and SHMT(1) C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China.
Esophageal Squamous Cell Carcinoma
[Correlations between Serine Hydroxymethyltransferase1 C1420T Polymorphisms and Susceptibilities to Esophageal Squamous Cell Carcinoma and Gastric Cardiac Adenocarcinoma.]
Essential Hypertension
Serine hydroxymethyltransferase 1 promoter hypermethylation increases the risk of essential hypertension.
Fatty Liver
Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease.
Folic Acid Deficiency
Effect of dietary folic acid deficiency on serine-glycine interconversion and the activity of liver serine hydroxymethyl transferase in the chick.
Glioblastoma
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
Glioma
Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells.
Glioma
Mitochondrial serine hydroxymethyltransferase 2 is a potential diagnostic and prognostic biomarker for human glioma.
Glioma
Overexpression of mitochondrial serine hydroxyl-methyltransferase 2 is associated with poor prognosis and promotes cell proliferation and invasion in gliomas.
Glioma
Serine-dependent redox homeostasis regulates glioblastoma cell survival.
Glioma
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
glycine hydroxymethyltransferase deficiency
Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders.
Head and Neck Neoplasms
DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.
Head and Neck Neoplasms
Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.
Heart Defects, Congenital
Maternal and infant genetic variants, maternal periconceptional use of selective serotonin reuptake inhibitors, and risk of congenital heart defects in offspring: population based study.
Hepatitis B
Increased Expression of Serine Hydroxymethyltransferase 2 (SHMT2) is a Negative Prognostic Marker in Patients with Hepatocellular Carcinoma and is Associated with Proliferation of HepG2 Cells.
Hodgkin Disease
Nutrients and Genetic Variation Involved in One-Carbon Metabolism and Hodgkin Lymphoma Risk: A Population-based Case-Control Study.
Hyperglycemia
Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
Hyperhomocysteinemia
Serine hydroxymethyltransferase 1 promoter hypermethylation increases the risk of essential hypertension.
Hyperphosphatemia
Role of Cytosolic Serine Hydroxymethyl Transferase 1 (SHMT1) in Phosphate-Induced Vascular Smooth Muscle Cell Calcification.
Hypertension
Impact of SHMT1 polymorphism on the clinical outcome of patients with metastatic colorectal cancer treated with first-line FOLFIRI+bevacizumab.
Hypertension
Serine hydroxymethyltransferase 1 promoter hypermethylation increases the risk of essential hypertension.
Infections
Increased Expression of Serine Hydroxymethyltransferase 2 (SHMT2) is a Negative Prognostic Marker in Patients with Hepatocellular Carcinoma and is Associated with Proliferation of HepG2 Cells.
Intestinal Neoplasms
Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of apcmin-mediated intestinal cancer risk.
Intestinal Neoplasms
SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production.
Ischemic Stroke
Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism.
Ischemic Stroke
The association between serine hydroxymethyl transferase 1 gene hypermethylation and ischemic stroke.
Kidney Neoplasms
Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer.
Leukemia
Association of Thymidylate Synthase 5'-UTR 28bp Tandem Repeat and Serine Hydroxymethyltransfarase C1420T Polymorphisms with Susceptibility to Acute Leukemia.
Leukemia
C1420T Polymorphism of Cytosolic Serine Hydroxymethyltransferase and Risk of Cancer: a Meta-analysis.
Leukemia
Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts.
Leukemia
Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy.
Leukemia
Thymidylate synthetase and serine transhydroxymethylase activities in preleukemic disorders of erythropoiesis and acute leukemia.
Leukemia, Experimental
[Study of serine hydroxymethyltransferase in experimental leukemias]
Leukemia, Myeloid, Acute
Evaluation of LKB1 and Serine-Glycine Metabolism Pathway Genes (SHMT1 and GLDC) Expression in AML.
Leukemia, Myeloid, Acute
Genetic variation in the folate metabolic pathway and risk of childhood leukemia.
Liver Neoplasms
Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma.
Liver Neoplasms
Increased Expression of Serine Hydroxymethyltransferase 2 (SHMT2) is a Negative Prognostic Marker in Patients with Hepatocellular Carcinoma and is Associated with Proliferation of HepG2 Cells.
Liver Neoplasms
The RFC1 80G>A, among Common One-Carbon Polymorphisms, Relates to Survival Rate According to DNA Global Methylation in Primary Liver Cancers.
Lung Neoplasms
A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.
Lung Neoplasms
Comprehensive evaluation of the response of genes to the administration of the antitumor drug S-1 using a low density array.
Lung Neoplasms
Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes.
Lung Neoplasms
Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments.
Lung Neoplasms
One carbon metabolism in human lung cancer.
Lung Neoplasms
Polymorphisms of cytosolic serine hydroxymethyltransferase and risk of lung cancer: a case-control analysis.
Lung Neoplasms
Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis.
Lung Neoplasms
SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production.
Lung Neoplasms
SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.
Lung Neoplasms
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.
Lymphatic Metastasis
High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors.
Lymphoma
Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma.
Lymphoma
Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts.
Lymphoma
The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing.
Lymphoma, Non-Hodgkin
Genetic polymorphisms in the one-carbon metabolism pathway genes and susceptibility to non-Hodgkin lymphoma.
Lymphoma, Non-Hodgkin
SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients.
Lymphoma, T-Cell
Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential.
Malaria
Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization.
Malaria
Possible selection of host folate pathway gene polymorphisms in patients with malaria from a malaria endemic region in North East India.
Malaria
Vitamin B6-dependent enzymes in the human malaria parasite Plasmodium falciparum: a druggable target?
Multiple Sclerosis
Association of SHMT1, MAZ, ERG, and L3MBTL3 Gene Polymorphisms with Susceptibility to Multiple Sclerosis.
Neoplasm Metastasis
Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting ?-catenin degradation.
Neoplasm Metastasis
Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity.
Neoplasm Metastasis
Gene expression signatures of primary and metastatic uterine leiomyosarcoma.
Neoplasm Metastasis
High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors.
Neoplasm Metastasis
Overexpression of SHMT2 Predicts a Poor Prognosis and Promotes Tumor Cell Growth in Bladder Cancer.
Neoplasm Metastasis
Prognostic and therapeutic value of mitochondrial serine hydroxyl-methyltransferase 2 as a breast cancer biomarker.
Neoplasm Metastasis
SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production.
Neoplasms
A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.
Neoplasms
A Review of Small-Molecule Inhibitors of One-Carbon Enzymes: SHMT2 and MTHFD2 in the Spotlight.
Neoplasms
Activities of serine hydroxymethyltransferase in murine tissues and tumours.
Neoplasms
An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery.
Neoplasms
Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis.
Neoplasms
Association between cytosolic serine hydroxymethyltransferase (SHMT1) gene polymorphism and cancer risk: a meta-analysis.
Neoplasms
Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.
Neoplasms
C1420T Polymorphism of Cytosolic Serine Hydroxymethyltransferase and Risk of Cancer: a Meta-analysis.
Neoplasms
Cancer cell resistance to aurora kinase inhibitors: identification of novel targets for cancer therapy.
Neoplasms
Cancer proteome and metabolite changes linked to SHMT2.
Neoplasms
Circ_0072995 Promotes Cell Carcinogenesis via Up-Regulating miR-149-5p-Mediated SHMT2 in Breast Cancer.
Neoplasms
Clinical significance of SHMT1 rs1979277 polymorphism in Asian solid tumors: evidence from a meta-analysis.
Neoplasms
Cloning and characterization of Plasmodium vivax serine hydroxymethyltransferase.
Neoplasms
Cloning, expression, activity and folding studies of serine hydroxymethyltransferase: a target enzyme for cancer chemotherapy.
Neoplasms
Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes.
Neoplasms
Cooperative interactions of tetrahydrofolate with purified pig kidney serine transhydroxymethylase and loss of this cooperativity in L1210 tumors and in tissues of mice bearing these tumors.
Neoplasms
Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting ?-catenin degradation.
Neoplasms
Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity.
Neoplasms
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.
Neoplasms
Dietary Uridine Decreases Tumorigenesis in the ApcMin/+ Model of Intestinal Cancer.
Neoplasms
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming.
Neoplasms
Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes.
Neoplasms
DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.
Neoplasms
Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma.
Neoplasms
Drosha-independent miR-6778-5p strengthens gastric cancer stem cell stemness via regulation of cytosolic one-carbon folate metabolism.
Neoplasms
EIF2A promotes cell survival during paclitaxel treatment in vitro and in vivo.
Neoplasms
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma.
Neoplasms
Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer.
Neoplasms
Expression of Glucose Metabolism-Related Proteins in Adrenal Neoplasms.
Neoplasms
Expression of metabolism-related proteins in invasive lobular carcinoma: comparison to invasive ductal carcinoma.
Neoplasms
Expression of serine and glycine-related enzymes in phyllodes tumor.
Neoplasms
Folate-mediated one-carbon metabolism: a targeting strategy in cancer therapy.
Neoplasms
Genetic variation in the folate metabolic pathway and risk of childhood leukemia.
Neoplasms
Genetic variation in the one-carbon transfer pathway and ovarian cancer risk.
Neoplasms
Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness.
Neoplasms
Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: The heme connection.
Neoplasms
Glycine supplementation in vitro enhances porcine preimplantation embryo cell number and decreases apoptosis but does not lead to live births.
Neoplasms
High Expression of Serine Hydroxymethyltransferase 2 Indicates Poor Prognosis of Gastric Cancer Patients.
Neoplasms
High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors.
Neoplasms
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.
Neoplasms
Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.
Neoplasms
HybridSucc: A Hybrid-learning Architecture for General and Species-specific Succinylation Site Prediction.
Neoplasms
Identification of three new compounds that directly target human serine hydroxymethyltransferase 2.
Neoplasms
Implication of the folate-methionine metabolism pathways in susceptibility to follicular lymphomas.
Neoplasms
In vivo MR studies of glycine and glutathione metabolism in a rat mammary tumor.
Neoplasms
Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients.
Neoplasms
Increased Expression of Serine Hydroxymethyltransferase 2 (SHMT2) is a Negative Prognostic Marker in Patients with Hepatocellular Carcinoma and is Associated with Proliferation of HepG2 Cells.
Neoplasms
Increased Expression of SHMT2 Is Associated With Poor Prognosis and Advanced Pathological Grade in Oral Squamous Cell Carcinoma.
Neoplasms
Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism.
Neoplasms
Metformin Is a Pyridoxal-5'-phosphate (PLP)-Competitive Inhibitor of SHMT2.
Neoplasms
MiR-218-5p Suppresses the Killing Effect of Natural Killer Cell to Lung Adenocarcinoma by Targeting SHMT1.
Neoplasms
Mitochondrial serine hydroxymethyltransferase 2 is a potential diagnostic and prognostic biomarker for human glioma.
Neoplasms
Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments.
Neoplasms
Molecular organization, catalytic mechanism and function of serine hydroxymethyltransferase--a potential target for cancer chemotherapy.
Neoplasms
Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis.
Neoplasms
NAD- and NADPH-Contributing Enzymes as Therapeutic Targets in Cancer: An Overview.
Neoplasms
New Mechanism of Bone Cancer Pain: Tumor Tissue-Derived Endogenous Formaldehyde Induced Bone Cancer Pain via TRPV1 Activation.
Neoplasms
Novel pyrrolo[3,2-d]pyrimidine compounds target mitochondrial and cytosolic one-carbon metabolism with broad-spectrum antitumor efficacy.
Neoplasms
Nucleotide biosynthesis arrest by silencing SHMT1 function via vitamin B6-coupled vector and effects on tumor growth inhibition.
Neoplasms
One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation.
Neoplasms
Overexpression of mitochondrial serine hydroxyl-methyltransferase 2 is associated with poor prognosis and promotes cell proliferation and invasion in gliomas.
Neoplasms
Overexpression of SHMT2 Predicts a Poor Prognosis and Promotes Tumor Cell Growth in Bladder Cancer.
Neoplasms
Polymorphisms of cytosolic serine hydroxymethyltransferase and risk of lung cancer: a case-control analysis.
Neoplasms
Positive correlation between expression level of mitochondrial serine hydroxymethyltransferase and breast cancer grade.
Neoplasms
Prognostic and therapeutic value of mitochondrial serine hydroxyl-methyltransferase 2 as a breast cancer biomarker.
Neoplasms
Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis.
Neoplasms
Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis.
Neoplasms
Serine catabolism regulates mitochondrial redox control during hypoxia.
Neoplasms
Serine hydroxymethyl transferase 1 stimulates pro-oncogenic cytokine expression through sialic acid to promote ovarian cancer tumor growth and progression.
Neoplasms
Serine hydroxymethyltransferase 2: a novel target for human cancer therapy.
Neoplasms
SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia.
Neoplasms
SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer.
Neoplasms
SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients.
Neoplasms
SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production.
Neoplasms
SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.
Neoplasms
SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation.
Neoplasms
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
Neoplasms
SHMT2 expression as a diagnostic and prognostic marker for thyroid cancer.
Neoplasms
SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma.
Neoplasms
Silencing SHMT2 inhibits the progression of tongue squamous cell carcinoma through cell cycle regulation.
Neoplasms
Study of SHMT2 Inhibitors and Their Binding Mechanism by Computational Alanine Scanning.
Neoplasms
Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells.
Neoplasms
The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy.
Neoplasms
The effect of L-2-amino-4-methoxy-trans-3-butenoic acid on serine hydroxymethyl transferase.
Neoplasms
The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism.
Neoplasms
The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review).
Neoplasms
The role of the folate pathway in pancreatic cancer risk.
Neoplasms
The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing.
Neoplasms
Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer.
Neoplasms
Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential.
Neoplasms
Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability.
Neoplasms
[Polymorphic variants of folate metabolizing genes (C677T and A1298C MTHFR, C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in West Siberian Region of Russia].
Neoplasms
[Regulation of serine hydroxymethyltransferase activity in normal, tumor, and host cells]
Neural Tube Defects
Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice.
Neural Tube Defects
Dietary Uridine Decreases Tumorigenesis in the ApcMin/+ Model of Intestinal Cancer.
Neural Tube Defects
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
Neural Tube Defects
Interaction between Maternal and Paternal SHMT1 C1420T Predisposes to Neural Tube Defects in the Fetus: Evidence from Case-Control and Family-Based Triad Approaches.
Neural Tube Defects
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.
Neuroblastoma
Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells.
Neuroblastoma
Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene.
Neuroblastoma
Serine catabolism regulates mitochondrial redox control during hypoxia.
Ovarian Neoplasms
Genetic variation in the one-carbon transfer pathway and ovarian cancer risk.
Ovarian Neoplasms
Serine hydroxymethyl transferase 1 stimulates pro-oncogenic cytokine expression through sialic acid to promote ovarian cancer tumor growth and progression.
Ovarian Neoplasms
SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production.
Pancreatic Neoplasms
Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.
Papilledema
Association of Genetics and B Vitamin Status With the Magnitude of Optic Disc Edema During 30-Day Strict Head-Down Tilt Bed Rest.
Parkinson Disease
The role of the one-carbon cycle in neuropsychiatric disease.
Phyllodes Tumor
Expression of serine and glycine-related enzymes in phyllodes tumor.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Association Between SHMT1 rs1979277 Polymorphism and Risk of Acute Lymphoblastic Leukemia: A Systematic Review and Meta-analysis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Association of SHMT1 gene polymorphisms with the risk of childhood acute lymphoblastic leukemia in a sample of Iranian population.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genetic variation in the folate metabolic pathway and risk of childhood leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy.
Prostatic Neoplasms
Associations of Folate, Vitamin B12, Homocysteine, and Folate-Pathway Polymorphisms with Prostate-Specific Antigen Velocity in Men with Localized Prostate Cancer.
Prostatic Neoplasms
Folate and B12 in prostate cancer.
Prostatic Neoplasms
Identification of TWIST-interacting genes in prostate cancer.
Prostatic Neoplasms
Role of polymorphic variants of MTR gene A2756G and SHMT1 gene C1420T in the development of prostatic cancer in residents of the Western Siberian Region of Russia.
Prostatic Neoplasms
Shmt2: A Stat3 Signaling New Player in Prostate Cancer Energy Metabolism.
Rectal Neoplasms
Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations.
Rectal Neoplasms
SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer.
Renal Insufficiency, Chronic
Role of Cytosolic Serine Hydroxymethyl Transferase 1 (SHMT1) in Phosphate-Induced Vascular Smooth Muscle Cell Calcification.
Reperfusion Injury
Downregulating Serine Hydroxymethyltransferase 2 Deteriorates Hepatic Ischemia-Reperfusion Injury through ROS/JNK/P53 Signaling in Mice.
Reperfusion Injury
[Protective effect of serine methyltransferase against hepatic ischemia-reperfusion injury in mice].
Rhabdomyosarcoma
Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-q14 amplification.
Sarcoma
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma.
Sarcoma
Sheep gene mapping: additional DNA markers included (CASB, CASK, LALBA, IGF-1 and AMH).
Scrapie
2-Aminoacrylate Stress Induces a Context-Dependent Glycine Requirement in ridA Strains of Salmonella enterica.
Scrapie
Decreased coenzyme A levels in ridA mutant strains of Salmonella enterica result from inactivated serine hydroxymethyltransferase.
Scrapie
Proton Nuclear Magnetic Resonance Metabolomics Corroborates Serine Hydroxymethyltransferase as the Primary Target of 2-Aminoacrylate in a ridA Mutant of Salmonella enterica.
Small Cell Lung Carcinoma
One carbon metabolism in human lung cancer.
Smith-Magenis Syndrome
Haploinsufficiency of cytosolic serine hydroxymethyltransferase in the Smith-Magenis syndrome.
Squamous Cell Carcinoma of Head and Neck
Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.
Squamous Cell Carcinoma of Head and Neck
Increased Expression of SHMT2 Is Associated With Poor Prognosis and Advanced Pathological Grade in Oral Squamous Cell Carcinoma.
Stomach Neoplasms
Drosha-independent miR-6778-5p strengthens gastric cancer stem cell stemness via regulation of cytosolic one-carbon folate metabolism.
Stomach Neoplasms
High Expression of Serine Hydroxymethyltransferase 2 Indicates Poor Prognosis of Gastric Cancer Patients.
Stomach Neoplasms
High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors.
Thyroid Cancer, Papillary
SHMT2 expression as a diagnostic and prognostic marker for thyroid cancer.
Thyroid Carcinoma, Anaplastic
SHMT2 expression as a diagnostic and prognostic marker for thyroid cancer.
Thyroid Neoplasms
SHMT2 expression as a diagnostic and prognostic marker for thyroid cancer.
Tuberculosis
Unusual structural, functional, and stability properties of serine hydroxymethyltransferase from Mycobacterium tuberculosis.
Urinary Bladder Neoplasms
Involvement of glycogen debranching enzyme in bladder cancer.
Urinary Bladder Neoplasms
Overexpression of SHMT2 Predicts a Poor Prognosis and Promotes Tumor Cell Growth in Bladder Cancer.
Urinary Bladder Neoplasms
Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer.
Vascular Calcification
Role of Cytosolic Serine Hydroxymethyl Transferase 1 (SHMT1) in Phosphate-Induced Vascular Smooth Muscle Cell Calcification.
Vitamin B 6 Deficiency
Elevations of serum cystathionine and total homocysteine in pyridoxine-, folate-, and cobalamin-deficient rats.
Wilms Tumor
Serine hydroxymethyl transferase 1 stimulates pro-oncogenic cytokine expression through sialic acid to promote ovarian cancer tumor growth and progression.
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Kruschwitz, H.; Ren, S.; Di Salvo, M.; Schifch, V.
Expression, purification, and characterization of human cytosolic serine hydroxymethyltransferase
Protein Expr. Purif.
6
411-416
1995
Homo sapiens
brenda
Appaji Rao, N.; Talwar, R.; Savithri, H.S.
Molecular organization, catalytic mechanism and function of serine hydroxymethyltransferase - a potential target for cancer chemotherapy
Int. J. Biochem. Cell Biol.
32
405-416
2000
Saccharomyces cerevisiae, Oryctolagus cuniculus, Escherichia coli, Ovis aries, Homo sapiens, Pisum sativum
brenda
Ogawa, H.; Gomi, T.; Fujioka, M.
Serine hydroxymethyltransferase and threonine aldolase: are they identical?
Int. J. Biochem. Cell Biol.
32
289-301
2000
Cricetulus griseus, Escherichia coli, Homo sapiens, Neurospora crassa, Oryctolagus cuniculus, Ovis aries, Pisum sativum, Rattus norvegicus, Vigna radiata
brenda
Chave, K.J.; Snell, K.; Sanders, P.G.
Isolation and characterization of human genomic sequences encoding cytosolic serine hydroxymethyltransferase
Biochem. Soc. Trans.
25
53S
1997
Homo sapiens
brenda
Liu, X.; Reig, B.; Nasrallah, I.M.; Stover, P.J.
Human cytoplasmic serine hydroxymethyltransferase is an mRNA binding protein
Biochemistry
39
11523-11531
2000
Homo sapiens
brenda
Lewis, R.M.; Godfrey, K.M.; Jackson, A.A.; Cameron, I.T.; Hanson, M.A.
Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supply
J. Clin. Endocrinol. Metab.
90
1594-1598
2005
Ovis aries, Homo sapiens, Rattus norvegicus
brenda
Agrawal, S.; Kumar, A.; Srivastava, V.; Mishra, B.N.
Cloning, expression, activity and folding studies of serine hydroxymethyltransferase: a target enzyme for cancer chemotherapy
J. Mol. Microbiol. Biotechnol.
6
67-75
2003
Escherichia coli, Homo sapiens
brenda
Fu, T.F.; Hunt, S.; Schirch, V.; Safo, M.K.; Chen, B.H.
Properties of human and rabbit cytosolic serine hydroxymethyltransferase are changed by single nucleotide polymorphic mutations
Arch. Biochem. Biophys.
442
92-101
2005
Homo sapiens, Oryctolagus cuniculus (P07511), Oryctolagus cuniculus
brenda
Perry, C.; Sastry, R.; Nasrallah, I.M.; Stover, P.J.
Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc: implications for inhibition of DNA replication
J. Biol. Chem.
280
396-400
2005
Homo sapiens
brenda
Franca, T.C.; Wilter, A.; Ramalho, T.C.; Pascutti, P.G.; Figueroa-Villar, J.D.
Molecular dynamics of the interaction of Plasmodium falciparum and human serine hydroxymethyltransferase with 5-formyl-6-hydrofolic acid analogues: design of new potential antimalarials
J. Braz. Chem. Soc.
17
1383-1392
2006
Plasmodium falciparum, Homo sapiens (P34896)
-
brenda
Choi, M.
Human serine hydroxymethyltransferase 2 (SHMT2) interacts with hnRNP D
Genes Genomics
30
541-548
2008
Homo sapiens
-
brenda
Siglioccolo, A.; Bossa, F.; Pascarella, S.
Structural adaptation of serine hydroxymethyltransferase to low temperatures
Int. J. Biol. Macromol.
46
37-46
2010
Geobacillus stearothermophilus, Oryctolagus cuniculus, Escherichia coli, Homo sapiens, Mus musculus
brenda
Fox, J.T.; Stover, P.J.
Mechanism of the internal ribosome entry site-mediated translation of serine hydroxymethyltransferase 1
J. Biol. Chem.
284
31085-31096
2009
Homo sapiens
brenda
Fox, J.T.; Shin, W.K.; Caudill, M.A.; Stover, P.J.
A UV-responsive internal ribosome entry site enhances serine hydroxymethyltransferase 1 expression for DNA damage repair
J. Biol. Chem.
284
31097-31108
2009
Homo sapiens
brenda
Anderson, D.D.; Woeller, C.F.; Chiang, E.P.; Shane, B.; Stover, P.J.
Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis
J. Biol. Chem.
287
7051-7062
2012
Homo sapiens
brenda
Pinthong, C.; Maenpuen, S.; Amornwatcharapong, W.; Yuthavong, Y.; Leartsakulpanich, U.; Chaiyen, P.
Distinct biochemical properties of human serine hydroxymethyltransferase compared with the Plasmodium enzyme: implications for selective inhibition
FEBS J.
281
2570-2583
2014
Plasmodium falciparum, Plasmodium vivax, Homo sapiens (P34896), Homo sapiens
brenda
di Salvo, M.L.; Contestabile, R.; Paiardini, A.; Maras, B.
Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection
Med. Hypotheses
80
633-636
2013
Homo sapiens (P34897)
brenda
Kim, D.; Fiske, B.P.; Birsoy, K.; Freinkman, E.; Kami, K.; Possemato, R.L.; Chudnovsky, Y.; Pacold, M.E.; Chen, W.W.; Cantor, J.R.; Shelton, L.M.; Gui, D.Y.; Kwon, M.; Ramkissoon, S.H.; Ligon, K.L.; Kang, S.W.; Snuderl, M.; Vander Heiden, M.G.; Sabatini, D.M.
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
Nature
520
363-367
2015
Homo sapiens (P34897), Homo sapiens
brenda
Yin, K.
Positive correlation between expression level of mitochondrial serine hydroxymethyltransferase and breast cancer grade
OncoTargets Ther.
8
1069-1074
2015
Homo sapiens
brenda
Amornwatcharapong, W.; Maenpuen, S.; Chitnumsub, P.; Leartsakulpanich, U.; Chaiyen, P.
Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior
Arch. Biochem. Biophys.
630
91-100
2017
Homo sapiens, Plasmodium vivax
brenda
Tramonti, A.; Nardella, C.; di Salvo, M.L.; Barile, A.; Cutruzzola, F.; Contestabile, R.
Human cytosolic and mitochondrial serine hydroxymethyltransferase isoforms in comparison full kinetic characterization and substrate inhibition properties
Biochemistry
57
6984-6996
2018
Homo sapiens (P34896), Homo sapiens (P34897), Homo sapiens
brenda
Paiardini, A.; Tramonti, A.; Schirch, D.; Guiducci, G.; di Salvo, M.L.; Fiascarelli, A.; Giorgi, A.; Maras, B.; Cutruzzola, F.; Contestabile, R.
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming
Biochim. Biophys. Acta
1864
1506-1517
2016
Homo sapiens (P34896), Homo sapiens (P34897), Homo sapiens
brenda
Paiardini, A.; Fiascarelli, A.; Rinaldo, S.; Daidone, F.; Giardina, G.; Koes, D.R.; Parroni, A.; Montini, G.; Marani, M.; Paone, A.; McDermott, L.A.; Contestabile, R.; Cutruzzola, F.
Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase
ChemMedChem
10
490-497
2015
Homo sapiens
brenda
Giardina, G.; Brunotti, P.; Fiascarelli, A.; Cicalini, A.; Costa, M.G.; Buckle, A.M.; di Salvo, M.L.; Giorgi, A.; Marani, M.; Paone, A.; Rinaldo, S.; Paiardini, A.; Contestabile, R.; Cutruzzola, F.
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state
FEBS J.
282
1225-1241
2015
Homo sapiens (P34896), Homo sapiens (P34897), Homo sapiens
brenda
Giardina, G.; Paone, A.; Tramonti, A.; Lucchi, R.; Marani, M.; Magnifico, M.C.; Bouzidi, A.; Pontecorvi, V.; Guiducci, G.; Zamparelli, C.; Rinaldo, S.; Paiardini, A.; Contestabile, R.; Cutruzzola, F.
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells
FEBS J.
285
3238-3253
2018
Homo sapiens (P34896)
brenda
Scaletti, E.; Jemth, A.S.; Helleday, T.; Stenmark, P.
Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs
FEBS Lett.
593
1863-1873
2019
Homo sapiens (P34897), Homo sapiens
brenda