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Information on EC 2.1.1.362 - [histone H4]-N-methyl-L-lysine20 N-methyltransferase

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IUBMB Comments
This entry describes a group of enzymes that catalyse a single methylation of monomethylated lysine20 of histone H4 (H4K20m1, generated by EC 2.1.1.361, [histone H4]-lysine20 N-methyltransferase), forming the dimethylated form. This modification is broadly distributed across the genome and is likely important for general chromatin-mediated processes. The double-methylated form of lysine20 in histone H4 is the most abundant methylation state of this residue and is found on ~80% of all histone H4 molecules. Full activity of the enzyme requires that the lysine at position 9 of histone H3 is trimethylated.
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Word Map
  • 2.1.1.362
  • trimethylation
  • chromatin
  • methyltransferases
  • monomethylated
  • heterochromatinization
  • h4k16ac
  • hp1
The enzyme appears in viruses and cellular organisms
Synonyms
histone H4 lysine20 di- and trimethyltransferase, histone H4-K20 trimethyltransferase,, histone methyltransferase, Hmt4-20/Suv4-20, KMT5C, papA2, SUV39H1, SUV420H2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + a [histone H4]-N6-methyl-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6,N6-dimethyl-L-lysine20
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S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
show the reaction diagram
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