BRENDA - Enzyme Database
show all sequences of 2.1.1.362

The histone methyltransferase SUV420H2 and heterochromatin proteins HP1 interact but show different dynamic behaviours

Souza, P.; Voelkel, P.; Trinel, D.; Vandamme, J.; Rosnoblet, C.; Heliot, L.; Angrand, P.; BMC Cell Biol. 10, 41 (2009)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
TAP-tagged protein is expressed in L929 cells
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
SUV420H2 is strongly associated to pericentric heterochromatin, the N-terminus of SUV420H2 comprising then catalytically active SET domain is dispersed within the nucleus, whereas the C-terminal part of the protein is associated with heterochromatin
Homo sapiens
5634
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
52000
-
about 52000 Da, SDS-PAGE
Homo sapiens
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
-
-
-
Purification (Commentary)
Purification (Commentary)
Organism
tandem affinity purification
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
S-adenosyl-L-methionine + histone H4(K20)
trimethylation at lysine 20 of histone H4
702886
Homo sapiens
?
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
histone methyltransferase
-
Homo sapiens
SUV420H2
-
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
TAP-tagged protein is expressed in L929 cells
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
SUV420H2 is strongly associated to pericentric heterochromatin, the N-terminus of SUV420H2 comprising then catalytically active SET domain is dispersed within the nucleus, whereas the C-terminal part of the protein is associated with heterochromatin
Homo sapiens
5634
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
52000
-
about 52000 Da, SDS-PAGE
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
tandem affinity purification
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
S-adenosyl-L-methionine + histone H4(K20)
trimethylation at lysine 20 of histone H4
702886
Homo sapiens
?
-
-
-
?
Other publictions for EC 2.1.1.362
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
702886
Souza
The histone methyltransferase ...
Homo sapiens
BMC Cell Biol.
10
41
2009
-
-
1
-
-
-
-
-
1
-
1
-
-
1
-
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1
-
-
-
-
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1
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2
-
-
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-
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1
-
-
-
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-
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1
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1
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-
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1
-
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1
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-
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-
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-
703868
Sakaguchi
Functional characterization of ...
Drosophila melanogaster
Genetics
179
317-322
2008
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-
-
-
-
-
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1
-
-
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5
-
-
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1
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1
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3
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1
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1
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1
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1
1
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-
485352
Fang
Purification and functional ch ...
Drosophila elegans, Drosophila melanogaster, Homo sapiens
Curr. Biol.
12
1086-1099
2002
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-
2
-
1
-
-
-
1
-
2
6
-
4
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1
5
-
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11
2
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2
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1
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1
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2
6
-
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1
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11
2
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