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Information on EC 2.1.1.184 - 23S rRNA (adenine2085-N6)-dimethyltransferase

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IUBMB Comments
ErmC is a methyltransferase that confers resistance to the macrolide-lincosamide-streptogramin B group of antibiotics by catalysing the methylation of 23S rRNA at adenine2085.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
2
+
adenine2085 in 23S rRNA
=
2
+
N6-dimethyladenine2085 in 23S rRNA
Synonyms
23S ribosomal RNA adenine N-6 methyltransferase, ErmC, ermC 23 S rRNA methyltransferase, ErmC 23S rRNA methyltransferase, ermC methylase, ErmC methyltransferase, ErmC', ErmC' methyltransferase, ErmC' MTase, erythromycin resistance protein, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 S-adenosyl-L-methionine + adenine2085 in 23S rRNA = 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA
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