EC Number   |
Natural Substrates |
|---|
   2.1.1.184 | 2 S-adenosyl-L-methionine + adenine2085 in 23S rRNA |
- |
| 2.1.1.184 | 2 S-adenosyl-L-methionine + adenine2085 in 23S rRNA |
ErmC is a methyltransferase that confers resistance to the macrolide-lincosamide-streptogramin B group of antibiotics by catalyzing the methylation of 23S rRNA at a specific adenine residue (A2085 in Bacillus subtilis) |
| 2.1.1.184 | 2 S-adenosyl-L-methionine + adenine2085 in 23S rRNA |
the rRNA methyltransferase ErmC0 transfers methyl groups from S-adenosyl-L-methionine to atom N6 of an adenine base within the peptidyltransferase loop of 23 S rRNA, thus conferring antibiotic resistance against a number of macrolide antibiotics |
| 2.1.1.184 | more |
direct autoregulatory mechanism operating at the posttranscriptional level and independently of the ermC methylase-mediated methylation of ribosomes. A translational repression model is suggested in which the ermC methyltransferase binds to its own mRNA, at a region that resembles the methylation target site on 23S rRNA |
| 2.1.1.184 | S-adenosyl-L-methionine + adenine2085 in 23S rRNA |
adenine2085 in 23S rRNA from Bacillus subtilis equals adenine2058 in Escherichia coli 23S rRNA |
