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Information on EC 1.8.99.5 - dissimilatory sulfite reductase

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IUBMB Comments
Contain siroheme. The enzyme is essential in prokaryotic sulfur-based energy metabolism, including sulfate/sulfite reducing organisms, sulfur-oxidizing bacteria, and organosulfonate reducers. In sulfur reducers it catalyses the reduction of sulfite to sulfide (reaction 1 in the right to left direction), while in sulfur oxidizers it catalyses the opposite reaction (reaction 2 in the left to right direction) . The reaction involves the small protein DsrC, which is present in all the organisms that contain dissimilatory sulfite reductase. During the process an intramolecular disulfide bond is formed between two L-cysteine residues of DsrC. This disulfide can be reduced by a number of proteins including DsrK and TcmB . This enzyme is different from EC 1.8.1.2, assimilatory sulfite reductase (NADPH), and EC 1.8.7.1, assimilatory sulfite reductase (ferredoxin), which are involved in sulfate assimilation.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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a [DsrC protein]-disulfide
+
2
+
3
=
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a [DsrC protein]-dithiol
+
2
+
2
a [DsrC protein]-S-sulfanyl-L-cysteine
+
3
+
3
=
+
a [DsrC protein]-disulfide
+
3
+
2
Synonyms
dsrab, siroheme sulfite reductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a [DsrC protein]-S-sulfanyl-L-cysteine + 2 acceptor + 3 H2O = sulfite + a [DsrC protein]-dithiol + 2 reduced acceptor + 2 H+
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(1b)
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a [DsrC protein]-S-sulfanyl-L-cysteine + 3 acceptor + 3 H2O = a [DsrC]-S-sulfo-L-cysteine + 3 reduced acceptor + H+
show the reaction diagram
(2a)
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-
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a [DsrC protein]-S-sulfanyl-L-cysteine + 3 acceptor + 3 H2O = sulfite + a [DsrC protein]-disulfide + 3 reduced acceptor + 2 H+
show the reaction diagram
(2), overall reaction
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a [DsrC]-S-sulfo-L-cysteine = sulfite + a [DsrC protein]-disulfide
show the reaction diagram
(2b)
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hydrogen sulfide + a [DsrC protein]-disulfide + 2 acceptor + 3 H2O = sulfite + a [DsrC protein]-dithiol + 2 reduced acceptor + 2 H+
show the reaction diagram
hydrogen sulfide + a [DsrC protein]-disulfide = a [DsrC protein]-S-sulfanyl-L-cysteine
show the reaction diagram
(1a)
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