Reference on EC 1.3.1.3 - DELTA4-3-oxosteroid 5beta-reductase and Organism(s) Homo sapiens and UniProt Accession P51857
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Charbonneau, A.; The, V.L.
Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme
Biochim. Biophys. Acta
1517
228-235
2001
Homo sapiens
Faucher, F.; Cantin, L.; Luu-The, V.; Labrie, F.; Breton, R.
The crystal structure of human DELTA4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism
Biochemistry
47
8261-8270
2008
Homo sapiens (P51857), Homo sapiens
Di Costanzo, L.; Drury, J.E.; Penning, T.M.; Christianson, D.W.
Crystal structure of human liver DELTA4-3-ketosteroid 5beta-reductase (AKR1D1) and implications for substrate binding and catalysis
J. Biol. Chem.
283
16830-16839
2008
Homo sapiens
Faucher, F.; Cantin, L.; Luu-The, V.; Labrie, F.; Breton, R.
Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition
Biochemistry
47
13537-13546
2008
Homo sapiens (P51857), Homo sapiens
Ueki, I.; Kimura, A.; Chen, H.L.; Yorifuji, T.; Mori, J.; Itoh, S.; Maruyama, K.; Ishige, T.; Takei, H.; Nittono, H.; Kurosawa, T.; Kage, M.; Matsuishi, T.
SRD5B1 gene analysis needed for the accurate diagnosis of primary 3-oxo-Delta4-steroid 5beta-reductase deficiency
J. Gastroenterol. Hepatol.
24
776-785
2009
Homo sapiens (P51857)
Di Costanzo, L.; Drury, J.E.; Christianson, D.W.; Penning, T.M.
Structure and catalytic mechanism of human steroid 5beta-reductase (AKR1D1)
Mol. Cell. Endocrinol.
301
191-198
2009
Homo sapiens (P51857), Homo sapiens
Palermo, M.; Marazzi, M.G.; Hughes, B.A.; Stewart, P.M.; Clayton, P.T.; Shackleton, C.H.
Human Delta4-3-oxosteroid 5beta-reductase (AKR1D1) deficiency and steroid metabolism
Steroids
73
417-423
2008
Homo sapiens (P51857), Homo sapiens
Mindnich, R.; Drury, J.E.; Penning, T.M.
The effect of disease associated point mutations on 5beta-reductase (AKR1D1) enzyme function
Chem. Biol. Interact.
191
250-254
2011
Homo sapiens
Drury, J.E.; Mindnich, R.; Penning, T.M.
Characterization of disease-related 5beta-reductase (AKR1D1) mutations reveals their potential to cause bile acid deficiency
J. Biol. Chem.
285
24529-24537
2010
Homo sapiens, Homo sapiens (P51857)
Chen, M.; Drury, J.E.; Penning, T.M.
Substrate specificity and inhibitor analyses of human steroid 5beta-reductase (AKR1D1)
Steroids
76
484-490
2011
Homo sapiens
Appanna, N.; Gibson, H.; Gangitano, E.; Dempster, N.J.; Morris, K.; George, S.; Arvaniti, A.; Gathercole, L.L.; Keevil, B.; Penning, T.M.; Storbeck, K.H.; Tomlinson, J.W.; Nikolaou, N.
Differential activity and expression of human 5beta-reductase (AKR1D1) splice variants
J. Mol. Endocrinol.
66
181-194
2021
Homo sapiens (P51857), Homo sapiens
