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Information on EC 1.2.1.30 - carboxylate reductase (NADP+)

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IUBMB Comments
The enzyme contains an adenylation domain, a phosphopantetheinyl binding domain, and a reductase domain, and requires activation by attachment of a phosphopantetheinyl group. The enzyme activates its substrate to an adenylate form, followed by a transfer to the phosphopantetheinyl binding domain. The resulting thioester is subsequently transferred to the reductase domain, where it is reduced to an aldehyde and released.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
aromatic acid reductase, aryl-aldehyde dehydrogenase (NADP+), more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an aromatic aldehyde + NADP+ + AMP + diphosphate = an aromatic acid + NADPH + H+ + ATP
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