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Information on EC 1.2.1.24 - succinate-semialdehyde dehydrogenase (NAD+) and Organism(s) Azospirillum brasilense and UniProt Accession Q1JUP4

for references in articles please use BRENDA:EC1.2.1.24
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EC Tree
IUBMB Comments
This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC 1.2.1.79 [succinate-semialdehyde dehydrogenase (NADP+)], and EC 1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NAD+.
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This record set is specific for:
Azospirillum brasilense
UNIPROT: Q1JUP4
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Word Map
The taxonomic range for the selected organisms is: Azospirillum brasilense
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
aldh5a1, aldh5a, aldehyde dehydrogenase 5a1, nad(+)-dependent succinic semialdehyde dehydrogenase, alphakgsa dehydrogenase, ssaldh, sso1629, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alphaKGSA dehydrogenase
-
dehydrogenase, succinate semialdehyde
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-
-
-
NAD(+)-dependent succinic semialdehyde dehydrogenase
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-
-
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SSADH
-
-
-
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succinate semialdehyde dehydrogenase
-
-
-
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succinate semialdehyde:NAD+ oxidoreductase
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-
-
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succinic semialdehyde dehydrogenase
-
-
-
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succinyl semialdehyde dehydrogenase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
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oxidation
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-
-
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reduction
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
succinate-semialdehyde:NAD+ oxidoreductase
This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC 1.2.1.79 [succinate-semialdehyde dehydrogenase (NADP+)], and EC 1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NAD+.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-95-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
show the reaction diagram
-
-
-
?
alpha-ketoglutaric semialdehyde + NAD+ + H2O
alpha-ketoglutarate + NADH
show the reaction diagram
-
-
-
?
alpha-ketoglutaric semialdehyde + NADP+ + H2O
alpha-ketoglutarate + NADPH
show the reaction diagram
-
-
-
?
betaine aldehyde + NAD+ + H2O
2-trimethylammonioacetate + NADH
show the reaction diagram
-
-
-
?
butanaldehyde + NAD+ + H2O
butanoate + NADH
show the reaction diagram
-
-
-
?
formaldehyde + NAD+ + H2O
formate + NADH
show the reaction diagram
-
-
-
?
glutaraldehyde + NAD+ + H2O
glutarate + NADH
show the reaction diagram
-
-
-
?
glyceraldehyde + NAD+ + H2O
glycerate + NADH
show the reaction diagram
-
-
-
?
glycoaldehyde + NAD+ + H2O
glycolate + NADH
show the reaction diagram
-
-
-
?
heptanaldehyde + NAD+ + H2O
heptanoate + NADH
show the reaction diagram
-
-
-
?
hexanaldehyde + NAD+ + H2O
hexanoate + NADH
show the reaction diagram
-
-
-
?
isobutyraldehyde + NAD+ + H2O
isobutyrate + NADH + H+
show the reaction diagram
-
-
-
?
octanaldehyde + NAD+ + H2O
octanoate + NADH
show the reaction diagram
-
-
-
?
pentanaldehyde + NAD+ + H2O
pentanoate + NADH
show the reaction diagram
-
-
-
?
propanaldehyde + NAD+ + H2O
propanoate + NADH
show the reaction diagram
-
-
-
?
succinate semialdehyde + NAD+ + H2O
succinate + NADH
show the reaction diagram
-
-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.011 - 0.0159
alpha-Ketoglutaric semialdehyde
0.0163
Glutaraldehyde
1 mM EDTA, 1 mM 2-mercaptoethanol, 66.7 mM potassium phosphate pH 7.2, 1.5 mM NAD+. 25°C
0.0385
succinate semialdehyde
1 mM EDTA, 1 mM 2-mercaptoethanol, 66.7 mM potassium phosphate pH 7.2, 1.5 mM NAD+. 25°C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
12.3 - 51.2
alpha-Ketoglutaric semialdehyde
12.3
Glutaraldehyde
1 mM EDTA, 1 mM 2-mercaptoethanol, 66.7 mM potassium phosphate pH 7.2, 1.5 mM NAD+. 25°C
31.7
succinate semialdehyde
1 mM EDTA, 1 mM 2-mercaptoethanol, 66.7 mM potassium phosphate pH 7.2, 1.5 mM NAD+. 25°C
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KGSD1_AZOBR
481
0
50831
Swiss-Prot
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
220000
gel-filtration
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tetramer
4 * 55000, gel-filtration, SDS-PAGE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Ni-affinity chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli as His-tag fusion protein
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Watanabe, S.; Kodaki, T.; Makino, K.
A novel alpha-ketoglutaric semialdehyde dehydrogenase: evolutionary insight into an alternative pathway of bacterial L-arabinose metabolism
J. Biol. Chem.
281
28876-28888
2006
Azospirillum brasilense (Q1JUP4), Azospirillum brasilense
Manually annotated by BRENDA team