Ligand succinic semialdehyde

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Basic Ligand Information

Molecular Structure
Picture of succinic semialdehyde (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H6O3
succinic semialdehyde
UIUJIQZEACWQSV-UHFFFAOYSA-N
Synonyms:
4-ketobutyrate, 4-Oxobutanoate, 4-oxobutyrate, hemisuccinic aldehyde, Oxobutanoate, Succinate-semialdehyde, succinate semialdehyde


Show all pahtways known for Show all BRENDA pathways known for succinic semialdehyde

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (27 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
succinic semialdehyde + NADPH + H+ = 4-hydroxybutyrate + NADP+
show the reaction diagram
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succinic semialdehyde + NADPH + H+ = 4-hydroxybutyrate + NADP+
show the reaction diagram
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succinic semialdehyde + NADPH + H+ = 4-hydroxybutyrate + NADP+
show the reaction diagram
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pyruvate + succinic semialdehyde = 4-hydroxy-2-oxo-1,7-heptanedioate
show the reaction diagram

In Vivo Product in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
gamma-hydroxybutyrate + NADP+ = succinic semialdehyde + NADPH
show the reaction diagram
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4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 = 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
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2-oxoglutarate = succinate semialdehyde + CO2
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (58 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
succinic semialdehyde + NADPH + H+ = 4-hydroxybutyrate + NADP+
show the reaction diagram
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succinic semialdehyde + NADH + H+ = 4-hydroxybutyrate + NAD+
show the reaction diagram
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succinic semialdehyde + NADPH + H+ = 4-hydroxybutyrate + NADP+
show the reaction diagram
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succinic semialdehyde + NADPH = ? + NADP+
show the reaction diagram
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4-oxobutyrate + NADPH + H+ = ?
show the reaction diagram
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succinate semialdehyde + H2O + O2 = succinate + H2O2
show the reaction diagram
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succinate semialdehyde + NAD+ = succinate + NADH + H+
show the reaction diagram
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succinate semialdehyde + NAD(P)+ + H2O = ? + NAD(P)H + H+
show the reaction diagram
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succinate semialdehyde + CoA + NAD+ = ?
show the reaction diagram
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succinic semialdehyde + NAD+ + H2O = succinate + NADH
show the reaction diagram
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succinic semialdehyde + NADP+ + H2O = ?
show the reaction diagram
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succinic semialdehyde + NAD+ = ? + NADH
show the reaction diagram
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succinate semialdehyde + coenzyme A + NADP+ = succinyl-CoA + NADPH + H+
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succinate-semialdehyde + coenzyme A + NADP+ = succinyl-CoA + NADPH + H+
show the reaction diagram
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succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+
show the reaction diagram
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succinic semialdehyde + H2O + oxidized benzyl viologen = succinic acid + H+ + reduced benzyl viologen
show the reaction diagram
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succinic semialdehyde + NADPH = ?
show the reaction diagram
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pyruvate + succinic semialdehyde = 4-hydroxy-2-oxo-1,7-heptanedioate
show the reaction diagram

Product in Enzyme-catalyzed Reactions (49 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
gamma-hydroxybutyrate + NADP+ = succinic semialdehyde + NADPH
show the reaction diagram
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4-hydroxybutyrate + NADP+ = 4-ketobutyrate + NADPH
show the reaction diagram
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hydroxybutyrate + NADP+ = oxobutanoate + NADPH
show the reaction diagram
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succinate + NADH = succinic semialdehyde + NAD+ + H2O
show the reaction diagram
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succinyl-CoA + NADPH + H+ = succinate-semialdehyde + coenzyme A + NADP+
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4-aminobutyric acid + H2O + O2 = 4-oxobutanoate + NH3 + H2O2
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4-aminobutanoate + pyruvate = 4-oxobutanoate + L-alanine
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D-aminobutanoate + 2-oxoglutarate = oxobutanoate + D-glutamate
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4-aminobutanoate + 2-oxoglutarate = succinic semialdehyde + L-glutamate
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4-aminobutanoate + 2-oxoglutarate = 4-oxobutanoate + L-glutamate
show the reaction diagram
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4-aminobutanoate + pyruvate = succinic semialdehyde + L-alanine
show the reaction diagram
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gamma-amino-n-butyrate + 4,5-dioxopentanoate = 5-aminolevulinate + succinic semialdehyde
show the reaction diagram
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4-aminobutyrate + 2-oxoglutarate = succinic semialdehyde + L-glutamate
show the reaction diagram
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4-aminobutanoate + 2-oxoglutarate = 4-oxobutanoate + D-glutamate
show the reaction diagram
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3-(acetamidomethylene)succinate + H2O = acetate + 4-oxobutanoate + NH3 + CO2
show the reaction diagram
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2-oxoglutarate = succinate semialdehyde + CO2
show the reaction diagram
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2-oxoglutarate = CO2 + succinate semialdehyde
show the reaction diagram
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4-hydroxy-2-ketoheptane-1,7-dioate = pyruvate + succinic semialdehyde
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (37 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
90% substrate inhibition at 20 mM
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slight inhibition
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5 mM 65% inhibition
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non-competitive inhibitor
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67% inhibition at 2 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (4 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (50 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1329
-
with NADH as cosubstrate, at pH 8.0 and 37°C
17
-
recombinant enzyme, in 50 mM HEPES (pH 7.6), at 30°C; with as NADPH as cofactor, pH 7.6, 30°C
440
-
65°C, pH 7.9
0.76
-
-
5700
-
80°C, pH 8.4
10.8
-
with L-alanine as cosubstrate, in 50 mM TABS (pH 9), 1.5 mM dithiothreitol, 0.625 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 10% (v/v) glycerol, at 30°C
10.8
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reverse reaction with L-alanine, pH 9.0, 30°C
203.8
-
Kcat(app) with pyruvate as carbonyl donor, pH 8.0 and 25°C
64.9
-
pH 8.0, 25°C

KM Value (123 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.285
-
-
2.7
-
pH 8.5, 30°C
8
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pH 8.4, 80°C, formaldehyde ferredoxin oxidoreductase, benzyl viologen as electron acceptor
0.014
-
with L-alanine as cosubstrate, in 50 mM TABS (pH 9), 1.5 mM dithiothreitol, 0.625 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 10% (v/v) glycerol, at 30°C
0.014
-
reverse reaction with L-alanine, pH 9.0, 30°C
9.1
-
Km(app) with pyruvate as carbonyl donor, pH 8.0 and 25°C
73.8
-
pH 8.0, 25°C

Ki Value (9 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID
0.56
-
-
2169
0.0066
-
38°C, pH 8.5
13770
0.3
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in 50 mM Tris-HCl (pH 8.2), at 22°C
40061

References & Links

Links to other databases for succinic semialdehyde

ChEBI
PubChem
ChEBI
PubChem