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Information on EC 1.14.19.5 - acyl-CoA 11-(Z)-desaturase

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IUBMB Comments
The enzyme introduces a cis double bond at position C-11 of saturated fatty acyl-CoAs. In moths the enzyme participates in the biosynthesis of their sex pheromones. The enzyme from the marine microalga Thalassiosira pseudonana is specific for palmitoyl-CoA (16:0) , that from the leafroller moth Choristoneura rosaceana desaturates myristoyl-CoA (14:0) , while that from the moth Spodoptera littoralis accepts both substrates . The enzyme contains three histidine boxes that are conserved in all desaturases . It is membrane-bound, and contains a cytochrome b5-like domain at the N-terminus that serves as the electron donor for the active site of the desaturase.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
desat1, acyl-coa desaturase, tpdesn, z/e11-desaturase, acyl-coa delta11-desaturase, delta11-myristoyl-coa desaturase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + reduced acceptor + O2 = Delta11-acyl-CoA + acceptor + 2 H2O
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an acyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = an (11Z)-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O
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