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Ligand ferricytochrome b5

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Basic Ligand Information

Molecular Structure
Picture of ferricytochrome b5 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C36H36FeN4O2
ferricytochrome b5
VIJMEYIOPTVQKA-PVPKHRJZSA-N
Synonyms:
(ferricytochrome c)-subunit, (ferrocytochrome c)-subunit, ferricytochrome-b5, ferricytochrome b-561, ferricytochrome b1, ferricytochrome b559/569, Ferricytochrome c-553, ferricytochrome c2, ferricytochrome c3, ferricytochrome c551i, ferricytochrome c553, ferricytochrome cL, ferrileghemoglobin, ferrocytochrome b-561, ferrocytochrome b1, ferrocytochrome b5, ferrocytochrome b559/569, ferrocytochrome c-553, ferrocytochrome c2, ferrocytochrome c3, ferrocytochrome c551i, ferrocytochrome c553, ferrocytochrome cL, ferroleghemoglobin
Pathway Source
Pathways
MetaCyc
(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase), (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase), (5Z)-icosenoate biosynthesis, (8E,10E)-dodeca-8,10-dienol biosynthesis, 24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms) more


Show all pahtways known for Show all BRENDA pathways known for ferricytochrome b5

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (105 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-lactate + ferricytochrome c-553 = pyruvate + ferrocytochrome c-553
show the reaction diagram
-
methanol + ferricytochrome c551i = formaldehyde + ferrocytochrome c551i
show the reaction diagram
-
H2 + ferricytochrome c3 = H+ + ferrocytochrome c3
show the reaction diagram
-
24-methylidenecycloartanol + 6 ferrocytochrome b5 + 3 O2 + 6 H+ = 3beta-hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-ene-4alpha-carboxylate + 6 ferricytochrome b5 + 4 H2O
show the reaction diagram
-
a phytoceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (2'R)-2'-hydroxyphytoceramide + 2 ferricytochrome b5 + H2O
show the reaction diagram
-
icosanoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (Z)-icos-5-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ = (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-[glycerolipid] + ferricytochrome b5 + H2O
show the reaction diagram
-
alpha-linolenic acid + ferrocytochrome b5 + O2 + H+ = stearidonic acid + ferricytochrome b5 + H2O
show the reaction diagram
-
docosa-7,10,13,16,19-pentaenoic acid + 2 ferrocytochrome b5 + O2 + 2 H+ = docosa-4,7,10,13,16,19-hexaenoic acid + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
an oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12E)-octadeca-9,12-dienoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
myristic acid + 2 ferrocytochrome b5 + O2 + 2 H+ = (Z)-11-tetradecenoate + (E)-11-tetradecenoate + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+ = a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
pyruvate + ferricytochrome b1 + H2O = acetate + CO2 + ferrocytochrome b1
show the reaction diagram
-
nitrite + ferrocytochrome c2 = NO + H2O + ferricytochrome c2
show the reaction diagram
-
dimethyl sulfide + ferricytochrome c2 + H2O = dimethyl sulfoxide + ferrocytochrome c2
show the reaction diagram
-
thiosulfate + 2 ferrocytochrome c3 = sulfite + hydrogen sulfide + 2 ferricytochrome c3
show the reaction diagram
-
L-(+)-ascorbate + ferricytochrome b5 = monodehydro-L(+)-ascorbate + ferrocytochrome b5
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (101 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-lactate + ferricytochrome c-553 = pyruvate + ferrocytochrome c-553
show the reaction diagram
-
methanol + ferricytochrome c551i = formaldehyde + ferrocytochrome c551i
show the reaction diagram
-
H2 + ferricytochrome c3 = H+ + ferrocytochrome c3
show the reaction diagram
-
24-methylidenecycloartanol + 6 ferrocytochrome b5 + 3 O2 + 6 H+ = 3beta-hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-ene-4alpha-carboxylate + 6 ferricytochrome b5 + 4 H2O
show the reaction diagram
-
a phytoceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (2'R)-2'-hydroxyphytoceramide + 2 ferricytochrome b5 + H2O
show the reaction diagram
-
icosanoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (Z)-icos-5-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ = (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-[glycerolipid] + ferricytochrome b5 + H2O
show the reaction diagram
-
(4E)-sphing-4-enine ceramide + ferrocytochrome b5 + O2 + H+ = (4E,8E)-sphing-4,8-dienine ceramide + ferricytochrome b5 + H2O
show the reaction diagram
-
alpha-linolenic acid + ferrocytochrome b5 + O2 + H+ = stearidonic acid + ferricytochrome b5 + H2O
show the reaction diagram
-
docosa-7,10,13,16,19-pentaenoic acid + 2 ferrocytochrome b5 + O2 + 2 H+ = docosa-4,7,10,13,16,19-hexaenoic acid + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
an oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12E)-octadeca-9,12-dienoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
myristic acid + 2 ferrocytochrome b5 + O2 + 2 H+ = (Z)-11-tetradecenoate + (E)-11-tetradecenoate + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+ = a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
pyruvate + ferricytochrome b1 + H2O = acetate + CO2 + ferrocytochrome b1
show the reaction diagram
-
2 ferricytochrome c2 + NADPH = 2 ferrocytochrome c2 + NADP+ + H+
show the reaction diagram
-
nitrite + ferrocytochrome c2 = NO + H2O + ferricytochrome c2
show the reaction diagram
-
dimethyl sulfide + ferricytochrome c2 + H2O = dimethyl sulfoxide + ferrocytochrome c2
show the reaction diagram
-
thiosulfate + 2 ferrocytochrome c3 = sulfite + hydrogen sulfide + 2 ferricytochrome c3
show the reaction diagram
-
L-(+)-ascorbate + ferricytochrome b5 = monodehydro-L(+)-ascorbate + ferrocytochrome b5
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (254 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
methanol + ferricytochrome c551i = formaldehyde + ferrocytochrome c551i
show the reaction diagram
-
sphinganine ceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = 4-hydroxysphinganine ceramide + 2 ferricytochrome b5 + H2O
show the reaction diagram
-
icosanoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (Z)-icos-5-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
an oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12E)-octadeca-9,12-dienoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
myristic acid + 2 ferrocytochrome b5 + O2 + 2 H+ = (Z)-11-tetradecenoate + (E)-11-tetradecenoate + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+ = a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
octadec-9-ynoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = (13Z)-octadecen-13-en-9-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
formate + ferricytochrome c-553 = CO2 + ferrocytochrome c-553
show the reaction diagram
-
formaldehyde + ferricytochrome b559/569 + H2O = formate + ferrocytochrome b559/569 + 2 H+
show the reaction diagram
-
pyruvate + ferricytochrome b1 + H2O = acetate + CO2 + ferrocytochrome b1
show the reaction diagram
-
NADPH + H+ + ferricytochrome c2 = NADP+ + ferrocytochrome c2
show the reaction diagram
-
2 ferricytochrome b5 + NADH = 2 ferrocytochrome b5 + NAD+ + H+
show the reaction diagram
-
ferrileghemoglobin + NADH + H+ = ferroleghemoglobin + NAD+
show the reaction diagram
-
thiosulfate + 2 ferrocytochrome c3 = sulfite + hydrogen sulfide + 2 ferricytochrome c3
show the reaction diagram
-
dimethyl sulfide + ferricytochrome c2 + H2O = dimethyl sulfoxide + ferrocytochrome c2
show the reaction diagram
-
thiosulfate + 2 ferrocytochrome c3 = sulfite + hydrogen sulfide + 2 ferricytochrome c3
show the reaction diagram
-
adenylyl sulfate + ferrocytochrome c3 = AMP + sulfite + ferricytochrome
show the reaction diagram
-
ubiquinol + ferricytochrome b-561 = ubiquinone + ferrocytochrome b-561
show the reaction diagram
-
ferrocytochrome c553 + O2 + H+ = ferricytochrome c553 + H2O
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (227 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
methanol + ferricytochrome c551i = formaldehyde + ferrocytochrome c551i
show the reaction diagram
-
ferrocytochrome c2 + H2O2 = ferricytochrome c2 + OH-
show the reaction diagram
-
sphinganine ceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = 4-hydroxysphinganine ceramide + 2 ferricytochrome b5 + H2O
show the reaction diagram
-
icosanoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (Z)-icos-5-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ = (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-[glycerolipid] + ferricytochrome b5 + H2O
show the reaction diagram
-
alpha-linolenic acid + ferrocytochrome b5 + O2 + H+ = stearidonic acid + ferricytochrome b5 + H2O
show the reaction diagram
-
an oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12E)-octadeca-9,12-dienoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
myristic acid + 2 ferrocytochrome b5 + O2 + 2 H+ = (Z)-11-tetradecenoate + (E)-11-tetradecenoate + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+ = a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
octadec-9-ynoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = (13Z)-octadecen-13-en-9-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
formate + ferricytochrome c-553 = CO2 + ferrocytochrome c-553
show the reaction diagram
-
2 ferricytochrome c2 + NADPH = 2 ferrocytochrome c2 + NADP+ + H+
show the reaction diagram
-
2 ferricytochrome c2 + NADPH = 2 ferrocytochrome c2 + NADP+ + H+
show the reaction diagram
-
formaldehyde + ferricytochrome b559/569 + H2O = formate + ferrocytochrome b559/569 + 2 H+
show the reaction diagram
-
pyruvate + ferricytochrome b1 + H2O = acetate + CO2 + ferrocytochrome b1
show the reaction diagram
-
2 ferricytochrome b5 + NADH = 2 ferrocytochrome b5 + NAD+ + H+
show the reaction diagram
-
ferrileghemoglobin + NADH + H+ = ferroleghemoglobin + NAD+
show the reaction diagram
-
thiosulfate + 2 ferrocytochrome c3 = sulfite + hydrogen sulfide + 2 ferricytochrome c3
show the reaction diagram
-
dimethyl sulfide + ferricytochrome c2 + H2O = dimethyl sulfoxide + ferrocytochrome c2
show the reaction diagram
-
thiosulfate + 2 ferrocytochrome c3 = sulfite + hydrogen sulfide + 2 ferricytochrome c3
show the reaction diagram
-
ferrocytochrome c553 + O2 + H+ = ferricytochrome c553 + H2O
show the reaction diagram
-

Enzyme Cofactor/Cosubstrate (10 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (91 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
17.7
-
-
239
-
pH 7.6, 37°C
2.35
-
pH 7.5, 30°C
266
-
20°C, pH 7.4
5
-
-
252
-
-

KM Value (126 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0027
-
pH 7.6, 37°C
0.0176
-
pH 7.5, 30°C
0.029
-
-
0.021
-
in 220 mM Tris-HCl pH 8.0, 22°C
0.0009
-
-

References & Links