Ligand acyl-CoA

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of acyl-CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C25H41N7O17P3RS
acyl-CoA
BSJMWHQBCZFXBR-UHFFFAOYSA-N
Synonyms:
acyl-CoA (4 CH2), acyl-CoA derivatives, acyl-CoAs, acyl-CoA substrates, an acyl-CoA, CoA-acyl-esters, CoA esters, Straight chain acyl-CoA


Show all pahtways known for Show all BRENDA pathways known for acyl-CoA

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (59 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acyl-CoA + NAD+ = trans-2,3-didehydroacyl-CoA + NADH
show the reaction diagram
-
acyl-CoA + electron transfer flavoprotein = 2,3-dehydroacyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
-
acyl-CoA + 1-alkenylglycerophosphoethanolamine = CoA + 1-alkenyl-2-acylglycerophosphoethanolamine
show the reaction diagram
-
acyl-CoA + glycine = CoA + N-acylglycine
show the reaction diagram
-
acyl-CoA + L-carnitine = acyl-L-carnitine + CoA
show the reaction diagram
-
acyl-CoA + 1,2-diacyl-sn-glycerol = CoA + 1,2,3-triacylglycerol
show the reaction diagram
-
acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA
show the reaction diagram
-
acyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CoA + CO2
show the reaction diagram
-
acyl-CoA + sn-glycerol 3-phosphate = CoA + 2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
acyl-CoA + sphingosine = ?
show the reaction diagram
-
acyl-CoA + 2-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
-
acyl-CoA + retinol = CoA + retinyl ester
show the reaction diagram
-
acyl-CoA + glycerophosphocholine = CoA + 1-acyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
an acyl-CoA + H2O = a (2R)-2-alkyl-3-oxoalkanoate + CoA
show the reaction diagram
-
acyl-CoA + H2O = CoA + a carboxylate
show the reaction diagram
-
acyl-CoA + H2O = CoA + a carboxylate
show the reaction diagram
-
acyl-CoA + H2O = CoA + a carboxylate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxoacid + CoA + oxidized ferredoxin = acyl-CoA + CO2 + reduced ferredoxin + H+
show the reaction diagram
-
-
trans-didehydroacyl-CoA + NAD(P)H = acyl-CoA + NAD(P)+
show the reaction diagram
-
-
acyl-L-carnitine + CoA = acyl-CoA + L-carnitine
show the reaction diagram
-
-
CoA + 3-oxoacyl-CoA = acyl-CoA + acetyl-CoA
show the reaction diagram
-
-
acylcarnitine + CoASH = acyl-CoA + carnitine
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (161 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acyl-CoA + reduced acceptor + O2 = DELTA12-acyl-CoA + acceptor + H2O
show the reaction diagram
-
acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH
show the reaction diagram
-
acyl-CoA + NAD+ = trans-2,3-didehydroacyl-CoA + NADH
show the reaction diagram
-
acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor
show the reaction diagram
-
acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor
show the reaction diagram
-
acyl-CoA + 1-alkenylglycerophosphoethanolamine = CoA + 1-alkenyl-2-acylglycerophosphoethanolamine
show the reaction diagram
-
acyl-CoA + L-carnitine = acyl-L-carnitine + CoA
show the reaction diagram
-
acyl-CoA + 1,2-diacyl-sn-glycerol = CoA + 1,2,3-triacylglycerol
show the reaction diagram
-
acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA
show the reaction diagram
-
acyl-CoA + sn-glycerol 3-phosphate = CoA + 2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
acyl-CoA + sphinganine = N-acylsphinganine + CoA
show the reaction diagram
-
acyl-CoA + [acyl-carrier protein] = acyl-[acyl-carrier protein] + CoA
show the reaction diagram
-
acyl-CoA + L-serine = CoA + ?
show the reaction diagram
-
acyl-CoA + 2-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
-
acyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acyl-1-alkyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
acyl-CoA + retinol = CoA + retinyl ester
show the reaction diagram
-
acyl-CoA + glycerophosphocholine = CoA + 1-acyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
an acyl-CoA + H2O = a (2R)-2-alkyl-3-oxoalkanoate + CoA
show the reaction diagram
-
acyl-CoA + H2O = CoA + a carboxylate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxoacid + CoA + oxidized ferredoxin = acyl-CoA + CO2 + reduced ferredoxin + H+
show the reaction diagram
-
-
trans-didehydroacyl-CoA + NAD(P)H = acyl-CoA + NAD(P)+
show the reaction diagram
-
-
acyl-L-carnitine + CoA = acyl-CoA + L-carnitine
show the reaction diagram
-
-
acylcarnitine + CoASH = acyl-CoA + carnitine
show the reaction diagram
-
-

Enzyme Cofactor/Cosubstrate (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation, above 0.02 mM, in the presence of bovine serum albumin
-

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
strong substrate inhibition
-
at high concentrations
-
feedback inhibition, inhibition kinetics of recombinant isozyme mPanK2
-
weak inhibition
-
enzyme is substrate-inhibited at 0.005-0.01 mM of acyl-CoAs with chain length longer than C10
-

Enzyme Kinetic Parameters

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00105
0.0057
saturated and unsaturated acyl donors, human platelets

References & Links

Links to other databases for acyl-CoA

ChEBI
PubChem
-
PubChem