Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

No. of entries

Information on EC 1.14.15.30 - 3-ketosteroid 9alpha-monooxygenase

for references in articles please use BRENDA:EC1.14.15.30

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis. It forms a two-component system with a ferredoxin reductase (KshB). The enzyme contains a Rieske-type iron-sulfur center and non-heme iron. The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione.

The expected taxonomic range for this enzyme is: Bacteria, Archaea
Reaction Schemes

Synonyms
ksha1, ksha2, kshab, ksha5, ksha3, 3-ketosteroid 9-alpha-hydroxylase, 3-ketosteroid-9alpha-hydroxylase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
androsta-1,4-diene-3,17-dione + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
androstenedione degradation I (aerobic)