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Information on EC 1.14.13.178 - methylxanthine N1-demethylase

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IUBMB Comments
A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.179, methylxanthine N3-demethylase, and has a 5-fold higher activity with NADH than with NADPH . Also demethylate 1-methylxantine with lower efficiency. Forms part of the degradation pathway of methylxanthines.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
ndmA, P450-d, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
caffeine + O2 + NAD(P)H + H+ = theobromine + NAD(P)+ + H2O + formaldehyde
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paraxanthine + O2 + NAD(P)H + H+ = 7-methylxanthine + NAD(P)+ + H2O + formaldehyde
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theophylline + O2 + NAD(P)H + H+ = 3-methylxanthine + NAD(P)+ + H2O + formaldehyde
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