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(2S)-2,8-dihydroxy-2,3-dihydronaphthalene-1,4-dione + NADPH + H+
(2S,4R)-2,4,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one + NADP+
-
-
-
?
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
1,3,6,8-tetrahydroxynaphthalene + NADPH + H+
(R)-scytalone + NADP+
-
-
-
-
?
1,3,6,8-tetrahydroxynaphthalene + NADPH + H+
scytalone + NADP+
1,3,6-trihydroxynaphthalene + NADPH + H+
(R)-8-deoxyscytalone + NADP+
-
-
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
1,3-dihydroxynaphthalene + NADPH + H+
3-hydroxy-3,4-dihydronaphthalen-1(2H)-one + NADP+
-
very low activity
-
-
?
1,4-androstadiene-3,17-dione + NADPH + H+
? + NADP+
-
poor substrate of 3HNR
-
-
?
1-(1,6,8-trihydroxy-3-methylnaphthalen-2-yl)ethan-1-one + NADPH + H+
? + NADP+
-
-
-
?
1-(1,8-dihydroxy-3-methylnaphthalen-2-yl)ethan-1-one + NADPH + H+
? + NADP+
-
-
-
?
1-(3,6,8-trihydroxy-1-methylnaphthalen-2-yl)ethan-1-one + NADPH + H+
? + NADP+
-
-
-
?
2,(5alpha)-androstene-17-one + NADPH + H+
? + NADP+
-
-
-
-
?
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one + NAD+
?
-
-
-
-
?
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one + NADP+
4,5-Dihydroxy-2H-benzopyran-2-one + NADPH
2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one + NADP+
4,5-dihydroxy-2H-benzopyran-2-one + NADPH + H+
-
-
-
-
?
2,3-dihydronaphthalene-1,4-dione + NADPH + H+
(4S)-4-hydroxy-3,4-dihydronaphthalen-1(2H)-one + NADP+
-
-
21% yield, 98% enantiomeric excess
-
?
2,8-dihydroxynaphthalene-1,4-dione + NADPH + H+
(2S)-2,8-dihydroxy-2,3-dihydronaphthalene-1,4-dione + NADP+
-
-
-
?
2-hydroxyjuglone + NADPH + H+
(3S,4R)-3,4,8-trihydroxy-1-tetralone + NADP+
-
-
-
?
2-methylcyclohexanone + NADPH + H+
trans-2-methylcyclohexanol + NADP+
-
-
-
-
?
2-tetralone + NADPH + H+
2-tetralol + NADP+
-
high activity, almost complete conversion
-
-
?
3,4-dihydronaphthalen-2(1H)-one + NADPH + H+
(2S)-1,2,3,4-tetrahydronaphthalen-2-ol + NADP+
-
-
77% yield, 61% enantiomeric excess
-
?
4-androstene-3,17-dione + NADPH + H+
? + NADP+
-
poor substrate of 3HNR
-
-
?
4-estrene-3,17-dione + NADPH + H+
? + NADP+
-
poor substrate of 3HNR
-
-
?
5-androstene-3beta-ol-17-one + NADPH + H+
? + NADP+
-
-
-
-
?
5-hydroxy-2,3-dihydronaphthalene-1,4-dione + NADPH + H+
(4S)-4,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one + NADP+
-
-
9% yield, 95% enantiomeric excess
-
?
5-hydroxy-2-tetralone + NADPH + H+
5-hydroxy-2-tetralol + NADP+
-
-
-
-
?
5-methoxy-2-tetralone + NADPH + H+
5-methoxy-2-tetralol + NADP+
-
high activity, almost complete conversion
-
-
?
5alpha-androstane-3,17-dione + NADPH + H+
? + NADP+
-
best steroid substrate for 3HNR
-
-
?
5alpha-androstane-3-one + NADPH + H+
? + NADP+
-
-
-
-
?
5alpha-androstane-3alpha-ol-17-one + NADPH + H+
? + NADP+
-
-
-
-
?
5alpha-androstane-3beta-ol-17-one + NADPH + H+
? + NADP+
-
-
-
-
?
6-acetyl-2,5-dihydroxy-7-methylnaphthalene-1,4-dione + 2 NADPH + 2 H+
(3S,4R)-7-acetyl-3,4,8-trihydroxy-6-methyl-3,4-dihydronaphthalen-1(2H)-one + 2 NADP+
-
-
-
?
6-acetyl-2-hydroxy-5,7-dimethyl-4a,8a-dihydronaphthalene-1,4-dione + NADPH + H+
? + NADP+
-
-
-
?
6-hydroxy-2-tetralone + NADPH + H+
6-hydroxy-2-tetralol + NADP+
-
-
-
-
?
6-methoxy-2-tetralone + NADPH + H+
6-methoxy-2-tetralol + NADP+
-
-
-
-
?
6-methoxy-3,4-dihydronaphthalen-2(1H)-one + NADPH + H+
(2S)-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-ol + NADP+
-
-
71% yield, 99% enantiomeric excess
-
?
7-hydroxy-2-tetralone + NADPH + H+
7-hydroxy-2-tetralol + NADP+
-
high activity, almost complete conversion
-
-
?
7-methoxy-2-tetralone + NADPH + H+
7-methoxy-2-tetralol + NADP+
-
high activity, almost complete conversion
-
-
?
8-hydroxy-2-tetralone + NADPH + H+
8-hydroxy-2-tetralol + NADP+
-
high activity, almost complete conversion
-
-
?
8-methoxy-2-tetralone + NADPH + H+
8-methoxy-2-tetralol + NADP+
-
high activity, almost complete conversion
-
-
?
8-methoxy-3,4-dihydronaphthalen-2(1H)-one + NADPH + H+
(2R)-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-ol + NADP+
-
-
75% yield, 99% enantiomeric excess
-
?
lawsone + 2 NADPH + 2 H+
(3S,4R)-3,4-dihydroxy-1-tetralone + 2 NADP+
-
-
-
?
Phenanthrenequinone + NADPH
?
-
-
-
-
?
additional information
?
-
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
-
-
-
-
?
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
-
the enzyme is involved in melanin biosynthesis and pathogenicity
-
-
?
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
-
involved in the biosynthesis of melanin
-
-
?
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
-
-
-
-
?
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
-
the enzyme is an essential enzyme in the biosynthesis of fungal melanin, DHN type melanin biosynthetic pathway
-
-
?
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
-
-
-
-
?
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
-
the enzyme is involved in the post-aromatic deoxygenation process of fungal melanin and pigments
-
-
?
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
-
-
-
?
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
-
-
-
-
?
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
-
-
r
?
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
-
essential reaction in the biosynthesis of melanin
-
-
?
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
-
the enzyme is involved in the biosynthesis of melanin
-
-
?
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
-
-
-
?
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
-
r
-
-
?
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
-
spefific for NADPH
-
-
?
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
-
the enzyme is involved in the pentaketide pathway of melanin and flaviolin and 2-HJ
-
-
?
1,3,6,8-tetrahydroxynaphthalene + NADPH + H+
scytalone + NADP+
-
reduction reaction via the via the 3-keto tautomer of 1,3,6,8-tetrahydroxynaphthalene
-
-
?
1,3,6,8-tetrahydroxynaphthalene + NADPH + H+
scytalone + NADP+
-
with enatiomeric excess of over 95%, reduction reaction via the via the 3-oxo tautomer of 1,3,6,8-tetrahydroxynaphthalene
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
-
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
-
-
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
-
-
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
-
the enzyme is an essential enzyme in the biosynthesis of fungal melanin
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
-
the enzyme is an essential enzyme in the biosynthesis of fungal melanin, DHN type melanin biosynthetic pathway
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
-
theoretical studies on energies of 1,3,6,8-trihydroxynaphthalene conformer stability, its tautomeric forms and their rotamers, by different methods, overview
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
-
-
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
-
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
-
-
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
-
r
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
-
1,3,8-trihydroxynaphthalene rapidly autooxidizes
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
-
ordered sequential mechanism with nucleotide binding first and leaving last
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
-
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
-
specific for NADPH
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
-
-
-
-
?
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one + NADP+
4,5-Dihydroxy-2H-benzopyran-2-one + NADPH
-
-
-
-
?
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one + NADP+
4,5-Dihydroxy-2H-benzopyran-2-one + NADPH
-
ir
-
?
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one + NADP+
4,5-Dihydroxy-2H-benzopyran-2-one + NADPH
-
substrate and product are stable in aerated aqueous solution
-
?
additional information
?
-
-
no activity with estrone
-
-
?
additional information
?
-
no substrates: menadione, plumbagin, 2-methoxy-1,4-naphthoquinone, 2-methoxyjuglone, 2-hydroxy-3-methyl-1,4-naphthoquinone
-
-
-
additional information
?
-
-
no substrates: menadione, plumbagin, 2-methoxy-1,4-naphthoquinone, 2-methoxyjuglone, 2-hydroxy-3-methyl-1,4-naphthoquinone
-
-
-
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1,3,8-Trihydroxynaphthalene
-
competitive to 1,3,6,8-tetrahydroxynaphthalene
1-[(Z)-2-bromo-2-nitroethenyl]-3-fluorobenzene
high in vivo activities against Magnaporthe oryzae, EC50 9.5 ppm
1-[(Z)-2-bromo-2-nitroethenyl]-4-ethylbenzene
beta-nitrostyrene compound highest inhibitory activity among compounds analyzed
1H-indene-1,3(2H)-dione
-
-
2,3,4,5,6-Pentachlorobenzyl alcohol
-
-
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one
5-methyl-(1,2,4)-triazolo[3,4-b]benzothiazole
-
tricyclazole, specific inhibitor of 3HNR
6-hydroxyflavone
-
inhibits by 15%
7,4'-Dihydroxyflavone
-
inhibits by 51%
7-hydroxyflavone
-
inhibits by 9%
acacetin
-
inhibits by 90%
baicalein
-
affects fungal pigmentation and growth, inhibits by 75%
chrysoeriol
-
inhibits by 55%
diosmetin
-
inhibits by 83%
ethyl 6-methyl-4-oxo-4H-chromene-2-carboxylate
-
-
ethyl 6-methyl-8-nitro-4-oxo-4H-chromene-2-carboxylate
-
-
fisetin
-
inhibits by 12%
flavanone
-
inhibits by 9%
flavone
-
inhibits by 38%
genistein
-
inhibits by 19%
genkwanin
-
inhibits by 28%
myricetin
-
inhibits by 13%
N-Methyl-2-quinolone
-
weak
pinostrobin
-
inhibits by 38%
quercetin
-
inhibits by 52%
s-Triazolo[4,3-a]-quinoline
-
weak
scutellarein
-
inhibits by 67%
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one
-
DDBO, an artificial substrate, chemical synthesis method development, overview
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one
-
activity of the holoenzyme is inhibited by high substrate concentrations. Apigenin prevents the substrate inhibition at high substrate concentrations
3,7-dihydroxyflavone
-
inhibits by 24%
3-hydroxyflavone
-
inhibits by 22%
5,7-dihydroxyflavone
-
inhibits by 88%
5,7-dihydroxyflavone
-
potent inhibitor of 3HNR
5-hydroxyflavone
-
inhibits by 30%
5-methoxyflavone
-
inhibits by 12%
apigenin
-
acts as competititive inhibitor of 3HNR, inhibits by 90%. The inhibitor is stacked between the phenol ring of Tyr208 and the coenzyme nicotinamide moiety, forming two Hbonds with Ser149 and Ser228, and Ser149 and Tyr163, respectively. It affects fungal pigmentation and growth
apigenin
-
strong inhibition of 3HNR by apigenin at low 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one concentrations and a steep increase of the activity at higher 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one concentrations
apigenin
-
potent inhibitor of 3HNR
Biochanin A
-
acts as competititive inhibitor of 3HNR. The inhibitor is stacked between the phenol ring of Tyr208 and the coenzyme nicotinamide moiety, forming two Hbonds with Ser149 and Ser228, and Ser149 and Tyr163, respectively
kaempferol
-
inhibits by 81%
kaempferol
-
potent inhibitor of 3HNR
luteolin
-
inhibits by 83%
luteolin
-
potent inhibitor of 3HNR
naringenin
-
inhibits by 56%
Tricyclazole
determination of sensitivity to tricyclazole of 129 single-conidial isolates of rice blast fungus Magnaporthe grisea. Sensitivities of GY-6 and DY-2, the most sensitive isolates, to tricyclazole are both unstable in sub-cultured single-conidial offspring isolates, with respective mean EC50 values of 5.40 and 4.50 mg/l calculated from seedling tests. There is no amino acid difference between them in the coding sequences of 1,3,6,8-tetrahydroxynaphthalene reductase and 1,3,8-trihydroxynaphthalene reductase among the isolates
Tricyclazole
-
binds at the active site in the vicinity of the NADPH nicotinamide ring
Tricyclazole
-
noncompetitive with respect to 1,3,6,8-tetrahydroxynaphthalene, uncompetitive with respect to 1,3,8-trihydroxynaphthalene
additional information
-
not inhibited by daidzein
-
additional information
-
the effect of melanin inhibitors on the enzyme activity can be used to predict their effect in preventing rice blast disease
-
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0.00058
1-[(Z)-2-bromo-2-nitroethenyl]-3-fluorobenzene
Pyricularia oryzae
pH 7.0, 30°C
0.00029
1-[(Z)-2-bromo-2-nitroethenyl]-4-ethylbenzene
Pyricularia oryzae
pH 7.0, 30°C
0.025
3,7-dihydroxyflavone
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one
0.025
3-hydroxyflavone
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one
0.0058
5,7-dihydroxyflavone
0.025
5-hydroxyflavone
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one
0.025
5-methoxyflavone
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one
0.023
7,4'-Dihydroxyflavone
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C
0.0049
acacetin
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C
0.012
baicalein
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C
0.018
chrysoeriol
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C
0.0057
diosmetin
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C
0.055
flavone
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C
0.026
quercetin
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C
0.015
scutellarein
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C
0.00023
Tricyclazole
Pyricularia oryzae
pH 7.0, 30°C
0.0058
5,7-dihydroxyflavone
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one
0.0058
5,7-dihydroxyflavone
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C
0.0031
apigenin
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one
0.0031
apigenin
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C
0.012
Biochanin A
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one
0.012
Biochanin A
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C
0.0079
kaempferol
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one
0.0079
kaempferol
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C
0.0068
luteolin
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one
0.0068
luteolin
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C
0.026
naringenin
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one
0.026
naringenin
Curvularia lunata
-
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C
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Wheeler, M.H.; Greenblatt, G.A.
The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease
Exp. Mycol.
12
151-160
1988
Pyricularia oryzae
-
brenda
Vidal-Cros, A.; Viviani, F.; Labesse, G.; Boccara, M.; Gaudry, M.
Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing
Eur. J. Biochem.
219
985-992
1994
Pyricularia grisea
brenda
Thompson, J.E.; Basarab, G.S.; Andersson, A.; Lindqvist, Y.; Jordan, D.B.
Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism
Biochemistry
36
1852-1860
1997
Pyricularia grisea
brenda
Andersson, A.; Jordan, D.; Schneider, G.; Valent, B.; Lindqvist, Y.
Crystallization and preliminary X-ray diffraction study of 1,3,8-trihydroxynaphthalene reductase from Magnaporthe grisea
Proteins Struct. Funct. Genet.
24
525-527
1996
Pyricularia grisea
brenda
Perpetua, N.S.; Kubo, Y.; Yasuda, N.; Takano, Y.; Furusawa, I.
Cloning and characterization of a melanin biosynthetic THR1 reductase gene essential for appressorial penetration of Colletotrichum lagenarium
Mol. Plant Microbe Interact.
9
323-329
1996
Colletotrichum lagenaria
brenda
Ichinose, K.; Kiyono, J.; Ebizuka, Y.; Sankawa, U.
Post-aromatic deoxygenation in polyketide biosynthesis: reduction of aromatic rings in the biosynthesis of fungal melanin and anthraquinone
Chem. Pharm. Bull.
41
2015-2021
1993
Phialocephala lagerbergii
brenda
Viviani, F.; Vors, J.P.; Gaudry, M.; Marquet, A.
Deoxygenation of polyphenols by ascomycetes: kinetic behavior of the NADPH-dependent naphthol dehydrogenase and inhibition by tricyclazole and its analogues
Bull. Soc. Chim. Fr.
130
395-404
1993
Pyricularia oryzae
-
brenda
Andersson, A.; Jordan, D.; Schneider, G.; Lindqvist, Y.
Crystal structure of the ternary complex of 1,3,8-trihydroxynaphthalene reductase from Magnaporthe grisea with NADPH and an active-site inhibitor
Structure
4
1161-1170
1996
Pyricularia grisea
brenda
Thompson, J.E.; Basarab, G.S.; Pierce, J.; Hodge, C.N.; Jordan, D.B.
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one: a nonphysiological substrate for fungal melanin biosynthetic enzymes
Anal. Biochem.
256
1-6
1998
Pyricularia grisea
brenda
Andersson, A.; Jordan, D.; Schneider, G.; Lindqvist, Y.
A flexible lid controls access to the active site in 1,3,8-trihydroxynaphthalene reductase
FEBS Lett.
400
173-176
1997
Pyricularia grisea
brenda
Tsuji, G.; Sugahara, T.; Fujii, I.; Mori, Y.; Ebizuka, Y.; Shiraishi, T.; Kubo, Y.
Evidence for involvement of two naphthol reductases in the first reduction step of melanin biosynthesis pathway of Colletotrichum lagenarium
Mycol. Res.
107
854-860
2003
Colletotrichum lagenaria
brenda
Brunskole, M.; Stefane, B.; Zorko, K.; Anderluh, M.; Stojan, J.; Lanisnik Rizner, T.; Gobec, S.
Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: Synthesis of artificial substrate, homology modelling and initial screening
Bioorg. Med. Chem.
16
5881-5889
2008
Curvularia lunata
brenda
Rostkowski, M.; Paneth, P.
Analysis of conformer stability for 1,3,8-trihydroxynaphthalene: natural substrate of fungal trihydroxynaphthalene reductase
J. Phys. Chem. B
111
8314-8320
2007
Fungi
brenda
Brunskole, M.; Zorko, K.; Kerbler, V.; Martens, S.; Stojan, J.; Gobec, S.; Lanisnik Rizner, T.
Trihydroxynaphthalene reductase of Curvularia lunata--a target for flavonoid action?
Chem. Biol. Interact.
178
259-267
2009
Curvularia lunata
brenda
Stojan, J.; Brunskole, M.; Rizner, T.
Simultaneous binding of coenzyme and two ligand molecules into the active site of fungal trihydroxynaphthalene reductase
Chem. Biol. Interact.
178
268-273
2009
Curvularia lunata
brenda
Kristan, K.; Brunskole, M.; Stojan, J.; Rizner, T.L.
Two homologous fungal carbonyl reductases with different substrate specificities
Chem. Biol. Interact.
178
295-302
2009
Curvularia lunata
brenda
Zhang, C.; Huang, X.; Wang, J.; Zhou, M.
Resistance development in rice blast disease caused by Magnaporthe grisea to tricyclazole
Pestic. Biochem. Physiol.
94
43-47
2009
Pyricularia grisea (Q9HFV6)
-
brenda
Schaetzle, M.A.; Flemming, S.; Husain, S.M.; Richter, M.; Guenther, S.; Mueller, M.
Tetrahydroxynaphthalene reductase: catalytic properties of an enzyme involved in reductive asymmetric naphthol dearomatization
Angew. Chem. Int. Ed. Engl.
51
2643-2646
2012
Pyricularia grisea
brenda
Chen, H.; Han, X.; Qin, N.; Wei, L.; Yang, Y.; Rao, L.; Chi, B.; Feng, L.; Ren, Y.; Wan, J.
Synthesis and biological evaluation of novel inhibitors against 1,3,8-trihydroxynaphthalene reductase from Magnaporthe grisea
Bioorg. Med. Chem.
24
1225-1230
2016
Pyricularia oryzae (Q12634), Pyricularia oryzae ATCC MYA-4617 (Q12634)
brenda
Conradt, D.; Schtzle, M.; Husain, S.; Mller, M.
Diversity in reduction with short-chain dehydrogenases: tetrahydroxynaphthalene reductase, trihydroxynaphthalene reductase, and glucose dehydrogenase
ChemCatChem
7
3116-3120
2015
Pyricularia oryzae
-
brenda
Thornton, C.R.; Ryder, L.S.; Le Cocq, K.; Soanes, D.M.
Identifying the emerging human pathogen Scedosporium prolificans by using a species-specific monoclonal antibody that binds to the melanin biosynthetic enzyme tetrahydroxynaphthalene reductase
Environ. Microbiol.
17
1023-1038
2015
Lomentospora prolificans
brenda
Sone, Y.; Nakamura, S.; Sasaki, M.; Hasebe, F.; Kim, S.; Funa, N.
Bacterial enzymes catalyzing the synthesis of 1,8-dihydroxynaphthalene, a key precursor of dihydroxynaphthalene melanin, from Sorangium cellulosum
Appl. Environ. Microbiol.
84
e00258
2018
Sorangium cellulosum
brenda
Saha, N.; Mueller, M.; Husain, S.M.
Asymmetric synthesis of natural cis-dihydroarenediols using tetrahydroxynaphthalene reductase and its biosynthetic implications
Org. Lett.
21
2204-2208
2019
Pyricularia grisea (Q9HFV6), Pyricularia grisea
brenda