Application | Comment | Organism |
---|---|---|
drug development | flavonoids inhibit 3HNR, which can thus be considered a potential target for flavonoid action. In addition to being a known target for different fungicides, 3HNR can also serve as an interesting and novel target for the development of antimycotics | Curvularia lunata |
Cloned (Comment) | Organism |
---|---|
expressed as a glutathione S-transferase (GST)-fusion protein in Escherichia coli BL21-AI cells | Curvularia lunata |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,7-dihydroxyflavone | inhibits by 24% | Curvularia lunata | |
3-hydroxyflavone | inhibits by 22% | Curvularia lunata | |
5,7-dihydroxyflavone | inhibits by 88% | Curvularia lunata | |
5-hydroxyflavone | inhibits by 30% | Curvularia lunata | |
5-methoxyflavone | inhibits by 12% | Curvularia lunata | |
6-hydroxyflavone | inhibits by 15% | Curvularia lunata | |
7,4'-Dihydroxyflavone | inhibits by 51% | Curvularia lunata | |
7-hydroxyflavone | inhibits by 9% | Curvularia lunata | |
acacetin | inhibits by 90% | Curvularia lunata | |
apigenin | acts as competititive inhibitor of 3HNR, inhibits by 90%. The inhibitor is stacked between the phenol ring of Tyr208 and the coenzyme nicotinamide moiety, forming two Hbonds with Ser149 and Ser228, and Ser149 and Tyr163, respectively. It affects fungal pigmentation and growth | Curvularia lunata | |
baicalein | affects fungal pigmentation and growth, inhibits by 75% | Curvularia lunata | |
Biochanin A | acts as competititive inhibitor of 3HNR. The inhibitor is stacked between the phenol ring of Tyr208 and the coenzyme nicotinamide moiety, forming two Hbonds with Ser149 and Ser228, and Ser149 and Tyr163, respectively | Curvularia lunata | |
chrysoeriol | inhibits by 55% | Curvularia lunata | |
diosmetin | inhibits by 83% | Curvularia lunata | |
fisetin | inhibits by 12% | Curvularia lunata | |
flavanone | inhibits by 9% | Curvularia lunata | |
flavone | inhibits by 38% | Curvularia lunata | |
genistein | inhibits by 19% | Curvularia lunata | |
genkwanin | inhibits by 28% | Curvularia lunata | |
kaempferol | inhibits by 81% | Curvularia lunata | |
luteolin | inhibits by 83% | Curvularia lunata | |
additional information | not inhibited by daidzein | Curvularia lunata | |
myricetin | inhibits by 13% | Curvularia lunata | |
naringenin | inhibits by 56% | Curvularia lunata | |
pinostrobin | inhibits by 38% | Curvularia lunata | |
quercetin | inhibits by 52% | Curvularia lunata | |
scutellarein | inhibits by 67% | Curvularia lunata |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.033 | - |
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one | at pH 7.0 and 25°C | Curvularia lunata |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Curvularia lunata | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by affinity binding followed by cleavage with thrombin | Curvularia lunata |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
11 | - |
2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one converted by the recombinant protein | Curvularia lunata |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one + NADP+ | - |
Curvularia lunata | 4,5-dihydroxy-2H-benzopyran-2-one + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3HNR | - |
Curvularia lunata |
trihydroxynaphthalene reductase | - |
Curvularia lunata |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Curvularia lunata |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0012 | - |
apigenin | - |
Curvularia lunata | |
0.0022 | - |
acacetin | - |
Curvularia lunata | |
0.0026 | - |
5,7-dihydroxyflavone | - |
Curvularia lunata | |
0.0026 | - |
diosmetin | - |
Curvularia lunata | |
0.0031 | - |
luteolin | - |
Curvularia lunata | |
0.0036 | - |
kaempferol | - |
Curvularia lunata | |
0.0054 | - |
baicalein | at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | |
0.0054 | - |
Biochanin A | at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | |
0.0068 | - |
scutellarein | at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | |
0.0081 | - |
chrysoeriol | at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | |
0.01 | - |
7,4'-Dihydroxyflavone | at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | |
0.012 | - |
quercetin | at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | |
0.012 | - |
naringenin | at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | |
0.025 | - |
flavone | at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0031 | - |
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | apigenin | |
0.0049 | - |
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | acacetin | |
0.0057 | - |
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | diosmetin | |
0.0058 | - |
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | 5,7-dihydroxyflavone | |
0.0068 | - |
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | luteolin | |
0.0079 | - |
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | kaempferol | |
0.012 | - |
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | baicalein | |
0.012 | - |
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | Biochanin A | |
0.015 | - |
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | scutellarein | |
0.018 | - |
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | chrysoeriol | |
0.023 | - |
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | 7,4'-Dihydroxyflavone | |
0.026 | - |
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | quercetin | |
0.026 | - |
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | naringenin | |
0.055 | - |
at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C | Curvularia lunata | flavone |