Literature summary for 1.1.1.252 extracted from

Stojan, J.; Brunskole, M.; Rizner, T.
Simultaneous binding of coenzyme and two ligand molecules into the active site of fungal trihydroxynaphthalene reductase (2009), Chem. Biol. Interact., 178, 268-273.

Search for more literature for 1.1.1.252

Cloned(Commentary)

Cloned (Comment)	Organism
expressed as a glutathione S-transferase (GST)-fusion protein in Escherichia coli BL21 cells	Curvularia lunata

Inhibitors

Inhibitors	Comment	Organism	Structure
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one	activity of the holoenzyme is inhibited by high substrate concentrations. Apigenin prevents the substrate inhibition at high substrate concentrations	Curvularia lunata
apigenin	strong inhibition of 3HNR by apigenin at low 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one concentrations and a steep increase of the activity at higher 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one concentrations	Curvularia lunata

Organism

Organism	UniProt	Comment	Textmining
Curvularia lunata	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
by affinity binding followed by cleavage with thrombin	Curvularia lunata

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one + NADP+	-	Curvularia lunata	4,5-dihydroxy-2H-benzopyran-2-one + NADPH + H+	-	?

Synonyms

Synonyms	Comment	Organism
3HNR	-	Curvularia lunata
trihydroxynaphthalene reductase	-	Curvularia lunata

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Curvularia lunata

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Release 2023.1 (January 2023)