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Information on EC 1.1.1.205 - IMP dehydrogenase and Organism(s) Trypanosoma brucei brucei and UniProt Accession P50098

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EC Tree
     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.205 IMP dehydrogenase
IUBMB Comments
The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.
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This record set is specific for:
Trypanosoma brucei brucei
UNIPROT: P50098
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The taxonomic range for the selected organisms is: Trypanosoma brucei brucei
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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IMP
+
NAD+
+
H2O
=
XMP
+
NADH
+
H+
+
+
=
+
+
Synonyms
impdh, imp dehydrogenase, inosine monophosphate dehydrogenase, impdh2, impdh1, inosine 5'-monophosphate dehydrogenase, inosine-5'-monophosphate dehydrogenase, impdh ii, imp dh, inosinate dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dehydrogenase, inosinate
-
-
-
-
IMP dehydrogenase
IMP oxidoreductase
-
-
-
-
IMPD
-
-
-
-
IMPDH
inosinate dehydrogenase
-
-
-
-
inosine 5'-monophosphate dehydrogenase
-
-
-
-
inosine monophosphate dehydrogenase
-
-
-
-
inosine monophosphate oxidoreductase
-
-
-
-
inosine-5'-monophosphate dehydrogenase
-
inosine-5'-phosphate dehydrogenase
-
-
-
-
inosinic acid dehydrogenase
-
-
-
-
Raspberry protein
-
-
-
-
SOI12
-
-
-
-
Superoxide-inducible protein 12
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
IMP:NAD+ oxidoreductase
The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-93-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
IMP + NAD+ + H2O
XMP + NADH + H+
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
IMP + NAD+ + H2O
XMP + NADH + H+
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(1,3,4-thiadiazol-2-yl)hex-4-enamide
14.50% inhibition at 0.001 mg
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(1H-1,2,4-triazol-5-yl)hex-4-enamide
46.13% inhibition at 0.001 mg
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(1H-tetrazol-5-yl)hex-4-enamide
22.99% inhibition at 0.001 mg
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(4H-1,2,4-triazol-4-yl)hex-4-enamide
14.29% inhibition at 0.001 mg
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(pyridin-2-yl)hex-4-enamide
7.83% inhibition at 0.001 mg
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(thiazol-2-yl)hex-4-enamide
22.27% inhibition at 0.001 mg
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enethioic S-acid
11.56% inhibition at 0.001 mg
(E)-N-hydroxy-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enamide
5.24% inhibition at 0.001 mg
(R,E)-7-hydroxy-5-methoxy-4-methyl-6-(3-methyl-6-(oxiran-2-yl)-6-oxohex-2-en-1-yl)isobenzofuran-1(3H)-one
9.03% inhibition at 0.001 mg
(S,E)-7-hydroxy-5-methoxy-4-methyl-6-(3-methyl-6-(oxiran-2-yl)-6-oxohex-2-en-1-yl)isobenzofuran-1(3H)-one
9.28% inhibition at 0.001 mg
Mycophenolic acid
82.99% inhibition at 0.001 mg, inhibits the enzyme activity and leads to complete inhibition of proliferation of Trypanosoma at below 0.001 mM. Mycophenolic acid derivatives can act as trypanocidal drugs with trypanocidal activity
Pentamidine
complete inhibition at 500 ng/ml
S-(prop-1-en-2-yl) (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enethioate
16.47% inhibition at 0.001 mg
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
IMDH_TRYBB
512
0
55709
Swiss-Prot
other Location (Reliability: 2)
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
serial femtosecond crystallography
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Sf9 insect cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Suganuma, K.; Sarwono, A.E.; Mitsuhashi, S.; J?kalski, M.; Okada, T.; Nthatisi, M.; Yamagishi, J.; Ubukata, M.; Inoue, N.
Mycophenolic acid and its derivatives as potential chemotherapeutic agents targeting inosine monophosphate dehydrogenase in Trypanosoma congolense
Antimicrob. Agents Chemother.
60
4391-4393
2016
Trypanosoma evansi, Trypanosoma congolense (A0A0S3MSA1), Trypanosoma congolense, Trypanosoma brucei brucei (P50098), Trypanosoma evansi Tansui, Trypanosoma brucei brucei GUTat3.1 (P50098), Trypanosoma congolense IL3000 (A0A0S3MSA1)
Manually annotated by BRENDA team
Nass, K.; Redecke, L.; Perbandt, M.; Yefanov, O.; Klinge, M.; Koopmann, R.; Stellato, F.; Gabdulkhakov, A.; Schoenherr, R.; Rehders, D.; Lahey-Rudolph, J.M.; Aquila, A.; Barty, A.; Basu, S.; Doak, R.B.; Duden, R.; Frank, M.; Fromme, R.; Kassemeyer, S.; Katona, G.; Kirian, R.; Liu, H.; Majoul, I.; Mart, M.a.r.t.i.
In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors
Nat. Commun.
11
620
2020
Trypanosoma brucei brucei (P50098)
Manually annotated by BRENDA team