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EC 2.4.1.69 Details
EC number
2.4.1.69
Accepted name
type 1 galactoside α-(1,2)-fucosyltransferase
Reaction
GDP-β-L-fucose + β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-R = GDP + α-L-fucosyl-(1→2)-β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-R
Other name(s)
galactoside 2-α-L-fucosyltransferase (ambiguous), blood group H α-2-fucosyltransferase (ambiguous), guanosine diphosphofucose-galactoside 2-L-fucosyltransferase, α-(1→2)-L-fucosyltransferase (ambiguous), α-2-fucosyltransferase (ambiguous), α-2-L-fucosyltransferase (ambiguous), blood-group substance H-dependent fucosyltransferase (ambiguous), guanosine diphosphofucose-glycoprotein 2-α-fucosyltransferase (ambiguous), guanosine diphosphofucose-β-D-galactosyl-α-2-L-fucosyltransferase (ambiguous), guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide α-L-fucosyltransferase (ambiguous), guanosine diphosphofucose-glycoprotein 2-α-L-fucosyltransferase (ambiguous), secretor-type β-galactoside α1→2fucosyltransferase, β-galactoside α1→2fucosyltransferase (ambiguous), GDP-β-L-fucose:β-D-galactosyl-R 2-α-L-fucosyltransferase (ambiguous), FUT2 (gene name), GDP-β-L-fucose:β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide 2-α-L-fucosyltransferase
Systematic name
GDP-β-L-fucose:β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-R α-(1,2)-L-fucosyltransferase (configuration-inverting)
CAS registry number
56093-23-3
Comment
The enzyme acts on a glycoconjugates where R (see reaction) is a glycoprotein or glycosphingolipid. The recognized moiety of the substrate is known as a type 1 histo-blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen. In humans the main enzyme performing this reaction is encoded by the FUT2 gene (also known as the Secretor gene), which is also able to act on type 2 substrates (see EC 2.4.1.344). The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates.
History
created 1972 (EC 2.4.1.89 created 1976, incorporated 1984), modified 2002, modified 2017
EC Tree
2.4.1.3 created 1961, deleted 1972
2.4.1.6 created 1961, deleted 1972
2.4.1.42 created 1972, deleted 1984
2.4.1.51 created 1972, deleted 1984
2.4.1.55 created 1972, deleted 1982
2.4.1.59 created 1972, deleted 1984
2.4.1.61 created 1972, deleted 1984
2.4.1.72 created 1972, deleted 1976
2.4.1.75 created 1976, deleted 2005
2.4.1.76 created 1976, deleted 1984
2.4.1.77 created 1976, deleted 1984
2.4.1.84 created 1976, deleted 1984
2.4.1.89 created 1976, deleted 1984
2.4.1.93 created 1976, deleted 2004
2.4.1.98 created 1980, deleted 1984
2.4.1.107 created 1983, deleted 1984
2.4.1.108 created 1983, deleted 1984
2.4.1.124 created 1984, deleted 2002
2.4.1.151 created 1984, deleted 2002
2.4.1.169 created 1989, deleted 2003
2.4.1.200 created 1992, deleted 2004
2.4.1.204 created 1992, deleted 2003
2.4.1.233 created 2004, deleted 2005