2.1.1.371: [histone H3]-lysine27 N-dimethyltransferase
This is an abbreviated version!
For detailed information about [histone H3]-lysine27 N-dimethyltransferase, go to the full flat file.
Reaction
2 S-adenosyl-L-methionine + = 2 S-adenosyl-L-homocysteine +
Synonyms
NSD3, NSD3L, SET1, SUVH1, WHISTLE, WHSC1L, WHSC1L1, Wolf-Hirschhorn syndrome candidate 1-like 1
ECTree
Advanced search results
Substrates Products
Substrates Products on EC 2.1.1.371 - [histone H3]-lysine27 N-dimethyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
S-adenosyl-L-methionine + a [histone H3]-L-lysine27
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27
-
-
-
?
S-adenosyl-L-methionine + [histone H3]-L-lysine27
S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine27
-
-
-
?
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine27
S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine27
-
-
-
?
?
-
Nsd3 is specific for the histones H3K4 and H3K27 residues
-
-
-
additional information
?
-
enzyme shows versatility in substrate recognition. In a pan-methylation assay of histone H3, H3K4me3 and H3K27me3 species are preferably detected rather than me1 and me2 species, and H3K79-me1 and -me2 species are favored against me3 species. NSD3 shows significant di-/tri-methylation of histone H4K20
-
-
-
additional information
?
-
SET1 methylates both K9 and less efficiently K27 of histone H3 in vitro, reactions of EC 2.1.1.368 and 2.1.1.371, respectively
-
-
-