Literature summary for 2.1.1.371 extracted from

Yu, Y.; Dong, A.; Shen, W.H
Molecular characterization of the tobacco SET domain protein NtSET1 unravels its role in histone methylation, chromatin binding, and segregation (2004), Plant J., 40, 699-711 .

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Organism

Organism	UniProt	Comment	Textmining
Nicotiana tabacum	Q93YF5	cf. EC 2.1.1.368	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	SET1 methylates both K9 and less efficiently K27 of histone H3 in vitro, reactions of EC 2.1.1.368 and 2.1.1.371, respectively	Nicotiana tabacum	?	-	-
S-adenosyl-L-methionine + a [histone H3]-L-lysine27	-	Nicotiana tabacum	S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27	-	?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27	-	Nicotiana tabacum	S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27	-	?

Synonyms

Synonyms	Comment	Organism
SET1	-	Nicotiana tabacum
SUVH1	-	Nicotiana tabacum

General Information

General Information	Comment	Organism
physiological function	ectopic expression of SET1 increases the amount of dimethylated H3K9 and induces chromosome-segregation defects in tobacco BY2 cells. The histone methyltransferase activity, the association with specific chromatin regions and with condensed chromosomes, and the cellular effects largely depend on the C-terminal region including the SET domain of the protein. The N-terminal part of SET1 is capable of targeting the green fluorescent protein to interphase chromatin. SET1 binds LHP1, the Arabidopsis homolog of animal heterochromatin protein 1, and LHP1 colocalizes with heterochromatin containing high amounts of dimethylated H3K9	Nicotiana tabacum

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Release 2023.1 (January 2023)