2.1.1.184: 23S rRNA (adenine2085-N6)-dimethyltransferase
This is an abbreviated version!
For detailed information about 23S rRNA (adenine2085-N6)-dimethyltransferase, go to the full flat file.
Word Map on EC 2.1.1.184
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2.1.1.184
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macrolide
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macrolide-lincosamide-streptogramin
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methyltransferases
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lincosamide
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unmethylated
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mtases
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streptogramine
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medicine
- 2.1.1.184
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macrolide
-
macrolide-lincosamide-streptogramin
- methyltransferases
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lincosamide
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unmethylated
- mtases
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streptogramine
- medicine
Reaction
2 S-adenosyl-L-methionine + = 2 S-adenosyl-L-homocysteine +
Synonyms
23S ribosomal RNA adenine N-6 methyltransferase, EC 2.1.1.48, ErmC, ermC 23 S rRNA methyltransferase, ErmC 23S rRNA methyltransferase, ermC methylase, ErmC methyltransferase, ErmC', ErmC' methyltransferase, ErmC' MTase, erythromycin resistance protein, rRNA methyltransferase ErmC', rRNA:m6A methyltransferase ErmC'
ECTree
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Reaction
Reaction on EC 2.1.1.184 - 23S rRNA (adenine2085-N6)-dimethyltransferase
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2 S-adenosyl-L-methionine + adenine2085 in 23S rRNA = 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA
2 S-adenosyl-L-methionine + adenine2085 in 23S rRNA = 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA
a model for the transition-state based on the atomic details of the active site is consistent with a one-step methyl-transfer
2 S-adenosyl-L-methionine + adenine2085 in 23S rRNA = 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA
a model of RNA-ErmC interaction involving multiple binding sites is proposed from the kinetic data
2 S-adenosyl-L-methionine + adenine2085 in 23S rRNA = 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA
ermC methylase reaction involves a sequential mechanism occurring by two consecutive random bi bi reactions
2 S-adenosyl-L-methionine + adenine2085 in 23S rRNA = 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA
ermC methylase reaction involves a sequential mechanism occurring by two consecutive random bi bi reactions
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