1.3.1.48: 13,14-dehydro-15-oxoprostaglandin 13-reductase

This is an abbreviated version!
For detailed information about 13,14-dehydro-15-oxoprostaglandin 13-reductase, go to the full flat file.

Reaction

Synonyms

15-hydroxyprostaglandin dehydrogenase, 15-keto-PG reductase, 15-ketoprostaglandin DELTA-13-reductase, 15-ketoprostaglandin DELTA13-reductase, 15-ketoprostaglandinDELTA13-reductase, 15-oxoprostaglandin 13-oxidase, 15-oxoprostaglandin 13-reductase, 15-oxoprostaglandin DELTA13-reductase, 15-oxoprostaglandin-DELTA13-reductase, 15-PGDH, Ad-PGR, bifunctional leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, bifunctional LTB4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, DELTA13-15-ketoprostaglandin reductase, leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase, leukotriene B4 dehydrogenase, leukotriene B4-12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, LTB4 12-HD/PGR, LTBDH/PGR, NAD(P)H-dependent alkenal/one oxidoreductase, PG reductase, PGR, PGR-2, PGR1, prostaglandin 13-reductase, prostaglandin DELTA13-reductase, prostaglandin reductase 1, reductase, 15-oxo-DELTA13-prostaglandin

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.48 13,14-dehydro-15-oxoprostaglandin 13-reductase

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Results	in table
2927	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
21	Cofactor
3	Crystallization (Commentary)
35	Disease/ Diagnostics
3	General Information
22	IC50 Value
55	Inhibitors
5	Ki Value [mM]
72	KM Value [mM]
3	Localization
1	Metals/Ions
9	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
21	Organism
6	Pathway
22	PDB ID
3	pH Optimum
2	pH Range
13	Purification (Commentary)
1	Reaction
4	Reaction Type
21	Reference
31	Source Tissue
22	Specific Activity [micromol/min/mg]
8	Storage Stability
123	Substrates and Products (Substrate)
3	Subunits
31	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
28	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.3.1.48 - 13,14-dehydro-15-oxoprostaglandin 13-reductase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00014

5-(2-chloro-3-((4-methylcyclohexyl)methoxy)benzylidene)-1,3-thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.00013

5-(2-chloro-3-((5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)oxy)benzylidene)-1,3-thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.00109

5-(2-chloro-3-(2-(4-methyl-1,3-thiazolidin-5-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.00023

5-(2-chloro-3-(2-(cyclohexyloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.00017

5-(2-chloro-3-(2-(propan-2-yloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.0103

5-(2-chloro-3-(2-(pyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.000029

5-(2-chloro-3-(2-cyclohexylethoxy)benzylidene)thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.00015

5-(2-chloro-3-(2-cyclopentylethoxy)benzylidene)-1,3-thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.000059

5-(2-chloro-3-(3-cyclohexylpropoxy)benzylidene)thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.00014

5-(2-chloro-3-(3-nitrophenoxy)benzylidene)-1,3-thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.000045

5-(2-chloro-3-(3-phenylpropoxy)benzylidene)thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.000095

5-(2-chloro-3-(4-cyclohexylbutoxy)benzylidene)thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.0117

5-(2-chloro-3-(4-nitrobenzyloxy)benzylidene)thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.000054

5-(2-chloro-3-(4-phenylbutoxy)benzylidene)thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.00036

5-(2-chloro-3-(cyclobutylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.000058

5-(2-chloro-3-(cyclohexylmethoxy)benzylidene)thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.000212

5-(2-chloro-3-(cyclohexyloxy)benzylidene)thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.00002

5-(2-chloro-3-(cyclopentylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.00258

5-(2-chloro-3-(cyclopentyloxy)benzylidene)-1,3-thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.000122

5-(2-chloro-3-phenethoxybenzylidene)thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.000257

5-(3-(benzyloxy)-2-chlorobenzylidene)thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356

0.00862

5-(3-(bicyclo[2.2.1]hept-2-ylmethoxy)-2-chlorobenzylidene)-1,3-thiazolidine-2,4-dione

Homo sapiens

-

pH 75, 37°C, recombinant GST-tagged enzyme

746356